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Open Reduction and Fixation of Late-Presenting Pediatric Supracondylar Humeral Fractures: A Prospective Study. 晚期小儿肱骨髁上骨折的切开复位固定术:一项前瞻性研究
IF 1.7
Orthopedic Research and Reviews Pub Date : 2024-09-21 eCollection Date: 2024-01-01 DOI: 10.2147/ORR.S474219
Mohammed A Abdelraheem
{"title":"Open Reduction and Fixation of Late-Presenting Pediatric Supracondylar Humeral Fractures: A Prospective Study.","authors":"Mohammed A Abdelraheem","doi":"10.2147/ORR.S474219","DOIUrl":"https://doi.org/10.2147/ORR.S474219","url":null,"abstract":"<p><strong>Background: </strong>Supracondylar humeral fracture (SCHF) is a common injury in children, and early treatment provides excellent results and prevents disabilities. Delayed presentation is still prevalent, mainly in developing countries, because many factors hinder the opportunity to receive appropriate treatment. Currently, there are no standard treatment protocols, and there is insufficient published literature on this topic. This study aimed to evaluate the effectiveness and outcomes of open reduction and Kirschner wire fixation using a triceps-sparing posterior approach in neglected cases with complicated fractures.</p><p><strong>Methods: </strong>This was a prospective multicenter clinical study conducted between July 2016 and June 2021, which included 28 pediatric patients with neglected SCHF who presented to the hospital for definitive treatment five days or more after initial trauma without previous surgical intervention. All the patients underwent open reduction and K-wire fixation using a posterior triceps-sparing approach. The final functional outcome was assessed using the Mayo Elbow Performance Index (MEPI) and Flynn criteria.</p><p><strong>Results: </strong>All fractures (100%) united within 3-5.5 weeks (mean 4 ± 0.7 weeks). Excellent scores observed in 67.9% (n = 19), good in 21.4% (n = 6), fair in 7.1% (n=2), and poor in 3.6% (n = 1) patients according to MEPI. Correspondingly, Flynn's criteria showed 96.4% (n = 27) satisfactory and 3.6% (n = 1) unsatisfactory outcome.</p><p><strong>Conclusion: </strong>Open reduction and fixation using Kirschner wires through the posterior triceps-sparing approach is an effective treatment method for late-presenting SCHF in children with consequent satisfactory results.</p>","PeriodicalId":19608,"journal":{"name":"Orthopedic Research and Reviews","volume":"16 ","pages":"221-231"},"PeriodicalIF":1.7,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11423837/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142351348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biomechanical Characteristics of Kissing Spine During Extension Using a Human Cadaveric Lumbar Spinal Model. 利用人体尸体腰椎模型研究伸展过程中亲吻脊柱的生物力学特征。
IF 1.7
Orthopedic Research and Reviews Pub Date : 2024-07-05 eCollection Date: 2024-01-01 DOI: 10.2147/ORR.S468237
Yuichi Kasai, Takaya Kato, Tadashi Inaba, Sotaro Baba, Permsak Paholpak, Taweechok Wisanuyotin, Weerachai Kosuwon, Hirohito Hirata, Tadatsugu Morimoto
{"title":"Biomechanical Characteristics of Kissing Spine During Extension Using a Human Cadaveric Lumbar Spinal Model.","authors":"Yuichi Kasai, Takaya Kato, Tadashi Inaba, Sotaro Baba, Permsak Paholpak, Taweechok Wisanuyotin, Weerachai Kosuwon, Hirohito Hirata, Tadatsugu Morimoto","doi":"10.2147/ORR.S468237","DOIUrl":"10.2147/ORR.S468237","url":null,"abstract":"<p><strong>Introduction: </strong>Although kissing spine syndrome in the lumbar spinal region is a relatively common condition in older adults, no study examining its biomechanical characteristics has been reported. We hypothesized that kissing of the spinous processes during extension causes an increase in the flexural rigidity of the spine and significantly limits the deformation behavior of extension, which in turn might cause lower back pain.</p><p><strong>Methods: </strong>Three test models (human cadavers A, B, and C) were prepared by removing supraspinal/interspinous ligaments between L4 and L5. The dental resin was attached to the cephalocaudal spinous process so that the spinous processes between L4 and L5 were almost in contact with each other to simulate the condition of a kissing spine. The flexion-extension direction's torque-range-of-motion (torque-ROM) curve was generated with a six-axis material tester for biomechanical measurements.</p><p><strong>Results: </strong>In all three models, the maximum ROMs at the time of extension were smaller than those at the time of flexion, and no sudden increase in torque was observed during extension.</p><p><strong>Conclusion: </strong>The results indicated no apparent biomechanical effects of kissing between the spinous processes, suggesting that the contact between the spinous processes has little involvement in the onset of lower back pain.</p>","PeriodicalId":19608,"journal":{"name":"Orthopedic Research and Reviews","volume":"16 ","pages":"199-203"},"PeriodicalIF":1.7,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11234890/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141580429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Outcomes and Management Strategies for Capitellum and Trochlea Fractures: A Systematic Review. 帽状腱膜和趾骨骨折的临床结果和管理策略:系统回顾
IF 1.7
Orthopedic Research and Reviews Pub Date : 2024-06-26 eCollection Date: 2024-01-01 DOI: 10.2147/ORR.S472482
Ali Lari, Yasmen Alrumaidhi, Diego Martinez, Amaar Ahmad, Hamad Aljuwaied, Mohammad Alherz, Carlos Prada
{"title":"Clinical Outcomes and Management Strategies for Capitellum and Trochlea Fractures: A Systematic Review.","authors":"Ali Lari, Yasmen Alrumaidhi, Diego Martinez, Amaar Ahmad, Hamad Aljuwaied, Mohammad Alherz, Carlos Prada","doi":"10.2147/ORR.S472482","DOIUrl":"10.2147/ORR.S472482","url":null,"abstract":"<p><strong>Purpose: </strong>Capitellum and trochlea fractures, also referred to as coronal shear fractures of the distal humerus, are infrequent yet challenging intra-articular fractures of the elbow. There are a variety of surgical approaches and fixation methods with often variable outcomes. This systematic review investigates interventions, outcomes and complications of capitellum and trochlea fractures.</p><p><strong>Methods: </strong>A systematic review of studies published in MEDLINE, EMBASE, Web of Science and Cumulative Index to Nursing and Allied Health literature (CINAHL) was conducted to assess the clinical outcomes of capitellum and trochlea fractures managed surgically. Data on patient demographics, surgical approach, implant usage, postoperative outcomes and complications were compiled.</p><p><strong>Results: </strong>Forty-one studies met the inclusion criteria with a total of 700 patients. Surgical interventions primarily utilized either the lateral (79%) or antero-lateral (15%) approaches with headless compression screws as the most common fixation method (68%). Clinical outcomes were measured using the Mayo Elbow Performance Index (MEPI) with a mean score of 89.9 (±2.6) and the DASH score with a mean of 16.9 (±7.3). Elbow range of motion showed a mean flexion of 126.3° (±19.4), extension of 5.71° (±11.8), pronation of 75.23° (±12.2), and supination of 76.6° (±9.8). The mean flexion-extension arc was 113.7° (±16.9), and the mean pronation-supination arc was 165.31° (±9.41). Complications occurred in 19.8% of cases, with re-interventions required in 8.3% of cases, mainly due to symptomatic implants and elbow stiffness requiring surgical release. Other complications included implant removal (10.4%), overall reported stiff elbows (6%), nerve palsies (2%), non-union (1.5%), and infection (1.2%).</p><p><strong>Conclusion: </strong>The treatment of capitellum and trochlea fractures yields satisfactory outcomes but has a considerable rate of complications and reoperations primarily due to symptomatic implants and elbow stiffness. There is noteworthy variability in the achieved range of motion, suggesting unpredictable outcomes. Deficits in functionality and range of motion are common after surgery, especially with more complex injury patterns.</p>","PeriodicalId":19608,"journal":{"name":"Orthopedic Research and Reviews","volume":"16 ","pages":"179-197"},"PeriodicalIF":1.7,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11214803/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141469900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modification of Ertl Operation for Short Stump. 针对短树桩修改 Ertl 操作。
IF 1.7
Orthopedic Research and Reviews Pub Date : 2024-06-22 eCollection Date: 2024-01-01 DOI: 10.2147/ORR.S459421
Viktor Ivanovych Shevchuk, Yurii Bezsmertnyi, Olexander Yuriyovych Bezsmertnyi, Olexander Yuriyovych Branitsky
{"title":"Modification of Ertl Operation for Short Stump.","authors":"Viktor Ivanovych Shevchuk, Yurii Bezsmertnyi, Olexander Yuriyovych Bezsmertnyi, Olexander Yuriyovych Branitsky","doi":"10.2147/ORR.S459421","DOIUrl":"10.2147/ORR.S459421","url":null,"abstract":"<p><strong>Background: </strong>Despite a sufficient number of papers on the technique of transtibial amputations, the technique of Ertl-type reamputation in short tibial stump remains unreported.</p><p><strong>Aim: </strong>To propose a modification of the Ertl operation in the proximal tibia.</p><p><strong>Case presentation: </strong>The technique of bone bridge creation in a patient with a malformed stump in the upper third of the tibia at the expense of the regenerate formed after corticotomy of the tibial remnant and dosed distraction of the graft by the Ilizarov apparatus is described. Radiological, ultrasound and MRI methods were used to control the regenerate. The follow-up period was 36 months. At 3.5 months, a synostosis was formed, which allowed primary and then permanent prosthesis with a full-contact prosthesis. At 36 months, the organotypic remodelling of the regenerate was completed. The patient works, uses the prosthesis for 15-16 hours a day, and walks on average 8-10 km.</p><p><strong>Conclusion: </strong>The use of the proposed method makes it possible to obtain tibial synostosis without their shortening with elimination of valgus deviation of the fibula stump and the possibility of early functional loading. Synostosis formation occurs within 3.5 months after surgery. Organotypic bone remodelling occurs during primary and then permanent prosthetics. The formed bone bridge has a large support area, which is maintained during the whole follow-up period of 36 months and allows to perform full-contact prosthetics with maximum load on the residual limb end.</p>","PeriodicalId":19608,"journal":{"name":"Orthopedic Research and Reviews","volume":"16 ","pages":"171-178"},"PeriodicalIF":1.7,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11204799/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141458560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Novel Diabetic Arthritic Model in Rats Induced by Streptozotocin, High-Fat Diet, and Complete Freund's Adjuvant. 链脲佐菌素、高脂饮食和全弗罗因德佐剂诱导的新型糖尿病大鼠关节炎模型
IF 2
Orthopedic Research and Reviews Pub Date : 2024-06-11 eCollection Date: 2024-01-01 DOI: 10.2147/ORR.S457848
Dimas Radithya Boedijono, Ismail Hadisoebroto Dilogo, Marcel Prasetyo, Radiana Dhewayani Antarianto, Fitriya Nur Annisa Dewi, Em Yunir, Aria Kekalih, Ahmad Nugroho, Dina Aprilya
{"title":"A Novel Diabetic Arthritic Model in Rats Induced by Streptozotocin, High-Fat Diet, and Complete Freund's Adjuvant.","authors":"Dimas Radithya Boedijono, Ismail Hadisoebroto Dilogo, Marcel Prasetyo, Radiana Dhewayani Antarianto, Fitriya Nur Annisa Dewi, Em Yunir, Aria Kekalih, Ahmad Nugroho, Dina Aprilya","doi":"10.2147/ORR.S457848","DOIUrl":"10.2147/ORR.S457848","url":null,"abstract":"<p><strong>Introduction: </strong>Ankle arthrodesis is one of the treatments of choice, particularly in late-stage and unstable diabetic Charcot arthropathy. Unfortunately, poor healing capacity might play a role in the high nonunion rate (10-40%). The advancement in regenerative medicine opens a new horizon for enhancing fusion after ankle arthrodesis in patients with poor healing capacity. However, a suitable small animal model is warranted to study the effectivity of these regenerative medicine approaches. Streptozotocin (STZ)-induced diabetes models and adjuvant-induced arthritis models with complete Freund's adjuvant are two established models. However, no study has combined those two models to make a diabetic arthritic model that more closely resembles the condition in Charcot arthropathy.</p><p><strong>Methods: </strong>Twenty male Sprague-Dawley rats were assigned into five groups, consisting of one control group, and four diabetic groups which were induced by STZ injection and a high-fat diet. Among these diabetic rats, two groups received complete Freund's adjuvant (CFA) injections to the left ankle of the hind limb. The control group, one of the diabetic-only groups, and one of the arthritic-diabetic-induced groups were euthanized at 4 weeks after STZ induction, and the remainder were euthanized 6 weeks after STZ induction. Clinical, radiological, and histological examinations were then compared in all five groups.</p><p><strong>Results: </strong>Diabetic status was successfully achieved in the model, which was maintained until the completion of the study. The CFA-induced ankles were significantly larger than the contralateral ankles in all groups (p<0.05). Histopathological evaluation confirmed arthritic changes in the CFA-induced group with less variability after 4 weeks of arthritis induction.</p><p><strong>Conclusion: </strong>This rat model of arthritic diabetic mimics the progressive and chronic nature of Charcot arthropathy in humans. This model can be further use to study treatments that might enhance the fusion rate in ankle arthrodesis in healing-defective patients such as those with diabetes.</p><p><strong>Level of clinical evidence: </strong>5.</p>","PeriodicalId":19608,"journal":{"name":"Orthopedic Research and Reviews","volume":"16 ","pages":"163-170"},"PeriodicalIF":2.0,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11179661/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141331531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnostic Accuracy of Integrating Ultrasound and Shear Wave Elastography in Assessing Carpal Tunnel Syndrome Severity: a Prospective Observational Study. 结合超声波和剪切波弹性成像评估腕管综合征严重程度的诊断准确性:一项前瞻性观察研究。
IF 2
Orthopedic Research and Reviews Pub Date : 2024-05-09 eCollection Date: 2024-01-01 DOI: 10.2147/ORR.S459993
Ahmed Mohamed El-Maghraby, Yassir Edrees Almalki, Mohammad Abd Alkhalik Basha, Mohamad Gamal Nada, Fatma El Ahwany, Sharifa Khalid Alduraibi, Shaker Hassan S Alshehri, Asim S Aldhilan, Ziyad A Almushayti, Alaa K Alduraibi, Mervat Aboualkheir, Osama Attia, Mona M Amer, Ahmed M Abdelkhalik Basha, Ibrahim M Eladl
{"title":"Diagnostic Accuracy of Integrating Ultrasound and Shear Wave Elastography in Assessing Carpal Tunnel Syndrome Severity: a Prospective Observational Study.","authors":"Ahmed Mohamed El-Maghraby, Yassir Edrees Almalki, Mohammad Abd Alkhalik Basha, Mohamad Gamal Nada, Fatma El Ahwany, Sharifa Khalid Alduraibi, Shaker Hassan S Alshehri, Asim S Aldhilan, Ziyad A Almushayti, Alaa K Alduraibi, Mervat Aboualkheir, Osama Attia, Mona M Amer, Ahmed M Abdelkhalik Basha, Ibrahim M Eladl","doi":"10.2147/ORR.S459993","DOIUrl":"10.2147/ORR.S459993","url":null,"abstract":"<p><strong>Purpose: </strong>Carpal tunnel syndrome (CTS) is a common condition characterized by compression of the median nerve (MN) within the carpal tunnel. Accurate diagnosis and assessment of CTS severity are crucial for appropriate management decisions. This study aimed to investigate the combined diagnostic utility of B-mode ultrasound (US) and shear wave elastography (SWE) for assessing the severity of CTS in comparison to electrodiagnostic tests (EDT).</p><p><strong>Materials and methods: </strong>This prospective observational study was conducted over 9-month periods at a tertiary care hospital. A total of 48 patients (36 females, 12 males; mean age 44 ± 10.9 years; age range 28-57 years) with clinically suspected CTS were enrolled. All patients underwent EDT, US, and SWE. Based on the EDT results, CTS cases were categorized into four groups: mild, moderate, severe, and negative. The cross-sectional area (CSA) and elasticity (E) of the MN were measured at the tunnel inlet (CSAu and Eu) and pronator quadratus region (CSAo and Eo). The differences (CSAu-CSAo and Eu-Eo) were calculated. The primary outcomes were the diagnostic performance of CSAu, CSAu-CSAo, Eu, and Eu-Eo in differentiating moderate/severe from mild/negative CTS compared to EDT findings. Secondary outcomes included a correlation of US/SWE parameters with EDT grades and between each other. ANOVA, correlation, regression, and receiver operating characteristic (ROC) curve analyses were performed.</p><p><strong>Results: </strong>CSAu and CSAu-CSAo increased progressively with worsening CTS severity. E measurements were significantly higher in moderate-to-severe CTS compared to mild or negative cases. The combined metric of CSAu-CSAo at a 5 mm threshold exhibited enhanced performance, with a higher sensitivity (83.3%), specificity (100%), and area under the curve (AUC) (0.98), surpassing the results of CSAu when used independently. Similarly, the SWE measurements indicated that Eu-Eo at a 56.1kPa cutoff achieved an AUC of 0.95, with a sensitivity of 93.3% and specificity of 94.4%, outperforming the metrics for Eu when used alone, which had an AUC of 0.93, with identical sensitivity and specificity values (93.3% and 94.4%, respectively).</p><p><strong>Conclusion: </strong>The integration of ultrasound, shear wave elastography, and electrodiagnostic tests provides a comprehensive approach to evaluate anatomical and neurological changes and guide management decisions for CTS.</p>","PeriodicalId":19608,"journal":{"name":"Orthopedic Research and Reviews","volume":"16 ","pages":"111-123"},"PeriodicalIF":2.0,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11090190/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140916952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High Complication and Revision Rates in Anatomical Total Shoulder Arthroplasty with the Combination of Polyethylene and Cementless Convertible Metal-Backed Glenoid Components: A Retrospective Cohort Study. 使用聚乙烯和无水泥可转换金属支撑盂状关节组件的解剖型全肩关节置换术并发症和翻修率较高:一项回顾性队列研究。
IF 2
Orthopedic Research and Reviews Pub Date : 2024-02-27 eCollection Date: 2024-01-01 DOI: 10.2147/ORR.S442128
Klaus W J Hanisch
{"title":"High Complication and Revision Rates in Anatomical Total Shoulder Arthroplasty with the Combination of Polyethylene and Cementless Convertible Metal-Backed Glenoid Components: A Retrospective Cohort Study.","authors":"Klaus W J Hanisch","doi":"10.2147/ORR.S442128","DOIUrl":"10.2147/ORR.S442128","url":null,"abstract":"<p><strong>Background: </strong>Historically, Metal-Backed (MB) glenoid components in anatomical total Shoulder arthroplasty (aTSA) are prone to failure primarily due to loosening between the metal and bony surface. However, newer generations of MB glenoid components have performed well in reverse shoulder arthroplasty (RSA), with convertibility being considered to be the most significant benefit of MB components. Theoretically, MB components may be a viable option in \"Rotator cuff at risk\" cases. The aim of this study is to compare revisions versus revision-free survivorship and highlight problems associated with using convertible MB glenoid components in aTSA.</p><p><strong>Methods: </strong>Between December 2015 and September 2018, aTSA was performed on 30 patients utilizing 32 implants with convertible MB glenoid (two patients were operated bilaterally). The first investigation was performed at a mean of 55.9 months (43-76) by search in the national registry for revisions with twelve cases. The second FU on all remaining patients without revisions was conducted at a mean of 54.9 months (46-71) through physical examination with fourteen patients (sixteen implants), with four patients missing. Demographic data, indications, complications, revisions, and re-operations were recorded for each patient.</p><p><strong>Results: </strong>High rates of complications led to revisions or re-operation in aTSA in combination with MB (15/32). Seven problems were associated with polyethylene (PE), which included loosening, disengagement, or wear. Eight complications were not directly associated with the MB component. There was one with loosening on the metal-bone interface side. Conversion to RSA was possible in three cases, and secondary cuff failure was seen once. High infection rates (2/32) led to a different strategy for antibiotics and preoperative preparations.</p><p><strong>Conclusion: </strong>MB glenoid components caused unacceptably high complication and revision rates in aTSA. PE wear, disengagement, or loosening were the main reasons for revisions. Therefore, procedures with MB glenoid components were abandoned in aTSA.</p><p><strong>Level of evidence: </strong>Level IV case series, treatment study.</p>","PeriodicalId":19608,"journal":{"name":"Orthopedic Research and Reviews","volume":"16 ","pages":"93-101"},"PeriodicalIF":2.0,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10908272/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140022351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy and Safety of Generic Alendronate for Osteoporosis Treatment. 非专利阿仑膦酸钠治疗骨质疏松症的有效性和安全性。
IF 2
Orthopedic Research and Reviews Pub Date : 2024-02-22 eCollection Date: 2024-01-01 DOI: 10.2147/ORR.S445202
Atthakorn Jarusriwanna, Saran Malisorn, Sirikarn Tananoo, Kwanchanok Areewong, Supachok Rasamimongkol, Artit Laoruengthana
{"title":"Efficacy and Safety of Generic Alendronate for Osteoporosis Treatment.","authors":"Atthakorn Jarusriwanna, Saran Malisorn, Sirikarn Tananoo, Kwanchanok Areewong, Supachok Rasamimongkol, Artit Laoruengthana","doi":"10.2147/ORR.S445202","DOIUrl":"10.2147/ORR.S445202","url":null,"abstract":"<p><strong>Background: </strong>While osteoporosis increases the risk of fragility fractures, bisphosphonate has been proven to increase bone strength and reduce the risk of vertebral and non-vertebral fractures. In addition to its efficacy, substituting the brand with generic medication is a strategy to optimize healthcare expenditures. This study aimed to evaluate the efficacy of generic alendronate treatment and assess potential adverse events in patients with osteoporosis.</p><p><strong>Materials and methods: </strong>A retrospective review was conducted on 120 patients who met the indications for osteoporosis treatment, received weekly generic alendronate (70 mg) for >1 year, and underwent evaluation through standard axial dual-energy X-ray absorptiometry (DXA). The outcomes of this study were the percent change in bone mineral density (BMD) at the lumbar spine, femoral neck, and total hip after one year of treatment. The major adverse events occurring during medication that led to the discontinuation of drug administration were documented.</p><p><strong>Results: </strong>Most patients were female (96.7%) with an average age of 69.0 ± 9.3 years. The percent change in BMD increased at all sites after one year of generic alendronate treatment (lumbar spine: 5.6 ± 13.7, <i>p</i>-value <0.001; femoral neck: 2.3 ± 8.3, <i>p</i>-value = 0.023; total hip: 2.1 ± 6.2, <i>p</i>-value = 0.003), with over 85% of patients experiencing increased or stable BMD. Three patients discontinued the medication due to adverse effects: two had dyspepsia, and one had persistent myalgia.</p><p><strong>Conclusion: </strong>Generic alendronate may be considered an effective antiresorptive agent for osteoporosis treatment with a low incidence of adverse effects.</p>","PeriodicalId":19608,"journal":{"name":"Orthopedic Research and Reviews","volume":"16 ","pages":"85-91"},"PeriodicalIF":2.0,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10895978/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139972927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
External Fixation as a Primary and Definitive Treatment for Complex Tibial Diaphyseal Fractures: An Underutilized and Efficacious Approach. 外固定作为复杂胫骨骺端骨折的主要和最终治疗方法:一种未被充分利用的有效方法。
IF 2
Orthopedic Research and Reviews Pub Date : 2024-02-21 eCollection Date: 2024-01-01 DOI: 10.2147/ORR.S450774
Ahmed Albushtra, Abdulsalam Hadi Mohsen, Khaled Ali Alnozaili, Faisal Ahmed, Younes Mohsen Ali Abdu Aljobahi, Fawaz Mohammed, Mohamed Badheeb
{"title":"External Fixation as a Primary and Definitive Treatment for Complex Tibial Diaphyseal Fractures: An Underutilized and Efficacious Approach.","authors":"Ahmed Albushtra, Abdulsalam Hadi Mohsen, Khaled Ali Alnozaili, Faisal Ahmed, Younes Mohsen Ali Abdu Aljobahi, Fawaz Mohammed, Mohamed Badheeb","doi":"10.2147/ORR.S450774","DOIUrl":"https://doi.org/10.2147/ORR.S450774","url":null,"abstract":"<p><strong>Background: </strong>External fixation is one of the most often utilized treatment options for complicated tibial diaphyseal fractures (TDF). The purpose of this study was to assess the efficacy of unilateral external fixators as primary and definitive therapy for complex TDF in a resource-limited setting.</p><p><strong>Materials and methods: </strong>A retrospective study between June 2016 and March 2021 included 110 subjects with TDF who were treated with an external fixator as definitive fixation in hospitals affiliated with Ibb University. The patient's demographic characteristics, complications, and outcomes were gathered and analyzed. Factors associated with pin site infection were also investigated.</p><p><strong>Results: </strong>The mean age was 42.1 ± 10.1 years, with 92.7% being male. Rural residents accounted for 22.7%. Smoking and diabetes mellitus were present in 27.3% and 30.0%, respectively. General complications occurred in 12.0%, with pulmonary embolism being the most common at 4.5%. Orthopedic complications included pin-track infections in 27.3% (30) and osteomyelitis in 1.8% (2). Pin site infections required medical treatment in 21 cases and external fixator changes in five. Two cases each needed several debridements for osteomyelitis and soft tissue. Full union occurred in 79.1% (87) over 23.1 ± 3.2 weeks and final alignment in 97.3% (107) over 34.8 ± 4.8 weeks. Malunions occurred in 1.8% (2), and one case had hypertrophic nonunion. Factors like rural residency, smoking, diabetes, open fractures, worst fracture grade (Gustilo and Anderson type C), and general complications occurrence significantly correlated with pin site infection (all p-values < 0.05).</p><p><strong>Conclusion: </strong>A unilateral external fixator as a primary and definitive treatment is a viable, simple, and effective option for TDF with a high success rate even in a resource-limited setting. In this study, residents in rural areas, smoking, diabetes, open fracture, worst fracture grade, and general complication occurrence were associated with pin site infection occurrence.</p>","PeriodicalId":19608,"journal":{"name":"Orthopedic Research and Reviews","volume":"16 ","pages":"75-84"},"PeriodicalIF":2.0,"publicationDate":"2024-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10894515/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139972928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patient Reported Clinical Outcomes Following PCL Suture Augmentation in Patients with Multiligamentous Knee Injury: A Retrospective Observational Study. 多韧带膝关节损伤患者 PCL 缝合增强术后患者临床疗效报告:回顾性观察研究
IF 2
Orthopedic Research and Reviews Pub Date : 2024-02-16 eCollection Date: 2024-01-01 DOI: 10.2147/ORR.S425781
Amir Fathi, Ashley A Thompson, Ioanna K Bolia, Cory K Mayfield, Shane S Korber, Avinash Iyer, George F Hatch Iii
{"title":"Patient Reported Clinical Outcomes Following PCL Suture Augmentation in Patients with Multiligamentous Knee Injury: A Retrospective Observational Study.","authors":"Amir Fathi, Ashley A Thompson, Ioanna K Bolia, Cory K Mayfield, Shane S Korber, Avinash Iyer, George F Hatch Iii","doi":"10.2147/ORR.S425781","DOIUrl":"10.2147/ORR.S425781","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the patient-reported outcomes between patients with posterior cruciate ligament (PCL) reconstruction or repair alone versus PCL reconstruction or repair with internal bracing (IB) in the context of multi-ligament knee injuries (MLKI).</p><p><strong>Methods: </strong>All patients who underwent surgical management of MLKI at two institutions between 2006 and 2020 were retrospectively identified and offered participation in the study. Patient reported outcomes were measured via three instruments: Lysholm Knee score, Multiligament Quality of Life (ML-QOL), and the Patient-Reported Outcomes Measurement Information System (PROMIS) computer adaptive testing (CAT). The postoperative outcomes and reoperation rates were compared between the internal bracing and non-internal bracing groups.</p><p><strong>Results: </strong>Fifty-two patients were analyzed; 34 were included in the IB group (17.6% female; age 33.1 ±1.60 years), and 18 were included in the non-IB group (11.1% female; age 34.1 ±3.72 years). Mean follow-up time of the entire cohort was 1.44 ± 0.22 years (IB: 1.21 ± 0.18; non-IB: 2.1 ±0.65). There were no significant differences between PROMIS CAT [PROMIS Pain (54.4 ±1.78 vs 51.7 ±1.70, p=0.319), Physical Function (44.3 ±2.27 vs 47.9 ±1.52, p=0.294), Mobility (44.0 ±1.71 vs 46.1 ±2.10, p=0.463)], ML-QOL [ML-QOL Physical Impairment (40.7 ±4.21 vs 41.7±5.10, p=0.884), Emotional Impairment (49.2 ±4.88 vs 44.7±5.87, p=0.579), Activity Limitation (43.5 ±4.56 vs 31.5±3.62, p=0.087), Societal Involvement (44.9 ±4.96 vs 37.5 ±5.30, p=0.345)] and Lysholm knee score (61.8 ±4.55 vs 61.0 ±4.95, p=0.916) postoperatively compared to the non-IB group.</p><p><strong>Conclusion: </strong>In this group of patients, function and patient-reported outcomes between patients treated with PCL reconstruction and repair without internal brace versus those with additional internal brace augmentation were not significantly different. Further research encompassing a larger patient sample is necessary to investigate the efficacy of the internal brace for PCL injury in the context of MLKI injuries.</p>","PeriodicalId":19608,"journal":{"name":"Orthopedic Research and Reviews","volume":"16 ","pages":"67-74"},"PeriodicalIF":2.0,"publicationDate":"2024-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10878190/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139913201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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