One Health最新文献

{"title":"A persona-based exploration of rabies post-exposure prophylaxis seeking behavior and its implication for communication strategic planning: Evidence from Thailand","authors":"Jitjayang Yamabhai ,&nbsp;Patoo Cusripituck ,&nbsp;Teerawan Mingbualuang ,&nbsp;Nareerat Sangkachai ,&nbsp;Wimwiga Sakchainanon ,&nbsp;Chanatda Tungwongjulaniam ,&nbsp;Onphirul Yurachai ,&nbsp;Ratana Theerawat ,&nbsp;Anuwat Wiratsudakul","doi":"10.1016/j.onehlt.2025.100980","DOIUrl":"10.1016/j.onehlt.2025.100980","url":null,"abstract":"<div><div>Rabies is a lethal zoonotic illness that claims over 59,000 lives annually. However, this fatality can be avoided by postexposure prophylaxis (PEP). This study aimed to identify and characterize different personas of individuals regarding their PEP-seeking behavior and develop tailored communication strategies to encourage PEP adoption among these distinct groups effectively. We categorized our subjects, residing in two districts of Chonburi province, Thailand, into three groups: (i) individuals with a history of dog bites who underwent PEP; (ii) individuals bitten by dogs who did not receive PEP; and (iii) individuals who had never been bitten. Subsequently, we employed an empathy map, a visual method, and a customer journey map to better understand the participants' experiences and perceptions. A total of 38 individuals were interviewed. We categorized the participants into three distinct personas: positive, neutral, and negative trends. Individuals classified within the positive trend strongly advocate for seeking rabies vaccines in the event of a dog bite. Meanwhile, individuals who have a neutral inclination are more likely to contemplate getting vaccinated following a dog bite, particularly if the injury is substantial. Those with a negative trend demonstrate a notable lack of attention or concern toward preventing rabies. A lack of attention to the potential severity of the issue characterizes their attitude. Notably, nearly half (44.74 %; 17/38) of the individuals involved in the study indicated utilizing interpersonal communication, followed by digital platforms (42.11 %; 16/38) and traditional communication channels (10.52 %; 5/38). Tailoring communication modalities to suit each specific group is crucial for effective outreach.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"20 ","pages":"Article 100980"},"PeriodicalIF":4.1,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143175759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Best practices for the experimental design of one health studies on companion animal and owner microbiomes – From data collection to analysis","authors":"Suzanne B. Clougher ,&nbsp;Dagmara Niedziela ,&nbsp;Piera Versura ,&nbsp;Grace Mulcahy","doi":"10.1016/j.onehlt.2025.100977","DOIUrl":"10.1016/j.onehlt.2025.100977","url":null,"abstract":"<div><div>The relationship between owner and companion animal represents an underestimated opportunity for the studying of One Health relationships between humans, animals, and the environment they share. Microbiome exchanges between owner and pet have been documented for the gut, skin, oral, and nasal microbiomes. These studies give a unique insight into bacterial flows between humans and animals, but come with their specific challenges.</div><div>This review discusses the data and sample collection challenges, as well as laboratory, bioinformatic and data analysis challenges specific to One Health studies on companion animal and owner microbiomes. We provide an overview of possible data to be collected and pitfalls to avoid during sample collection and conservation, DNA extraction, and library preparation. We present the main bioinformatics pipelines in sequencing-data microbiome analysis, as well as data analysis specific to pet-owner microbiome comparison. We review and compare three beta-diversity measures (Bray-Curtis dissimilarity, unweighted, and weighted UniFrac distances) for pet-owner distances and the tests to compare them. Finally, we propose a framework with key considerations to bear in mind when designing and carrying out owner-companion animal studies, as well as best practices to implement them.</div><div>Although these studies come with additional difficulties compared to species-specific microbiome studies, they offer the opportunity to identify biomarkers, environmental triggers, and impacts of pet-owner interactions across species.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"20 ","pages":"Article 100977"},"PeriodicalIF":4.1,"publicationDate":"2025-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143173488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mass rabies exposure of veterinary health care workers in Germany: Management, immune response, and tolerability of post exposure-prophylaxis","authors":"Lennart Lemmermann ,&nbsp;Jonathan Remppis ,&nbsp;Sabine Bélard ,&nbsp;Florian Steiner","doi":"10.1016/j.onehlt.2025.100978","DOIUrl":"10.1016/j.onehlt.2025.100978","url":null,"abstract":"<div><h3>Background</h3><div>Rabies is a fatal zoonotic disease caused by <em>Rabies lyssavirus</em>, primarily transmitted through dog bites. In 2008, Germany was declared free from terrestrial rabies by the WOAH. However, illegal pet imports can still lead to rabies exposure, as seen in the 2021 case of a rabid puppy illegally imported to Germany, resulting in a mass exposure incident.</div></div><div><h3>Methods</h3><div>This retrospective study assessed the post-exposure management of 39 veterinary clinic staff exposed to the rabid puppy, focusing on the practicability, immunogenicity, and tolerability of post-exposure prophylaxis (PEP). Data was collected from patient records and for follow-up by phone using standardized case record forms, entered into an Excel database, and analyzed descriptively. Ethics approval was obtained from the Ethics Committee of the University of Tübingen (8452022BO2).</div></div><div><h3>Results</h3><div>Exposed individuals received varying PEP regimens based on vaccination status and exposure level, including possible aerosol exposure. Most followed the Essen-Scheme, with some receiving human rabies immune globulin (hRIG). All developed protective antibody titers, and adverse reactions were generally mild.</div></div><div><h3>Conclusion</h3><div>This case highlights challenges in rabies mass exposure management and emphasizes needs for continued preparedness, resource allocation and education about rabies, even in regions considered rabies-free.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"20 ","pages":"Article 100978"},"PeriodicalIF":4.1,"publicationDate":"2025-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143175758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, attitudes, and practices of Native Americans in northern California regarding ticks and tick-borne diseases","authors":"Patricia Torres ,&nbsp;Elizabeth F. Pienaar ,&nbsp;Michelle A. Ritchie ,&nbsp;Mourad W. Gabriel ,&nbsp;Michael J. Yabsley","doi":"10.1016/j.onehlt.2025.100976","DOIUrl":"10.1016/j.onehlt.2025.100976","url":null,"abstract":"<div><div>Reports of tick-borne diseases (TBDs) are increasing worldwide, particularly in North America where a diversity of endemic and exotic tick species and pathogens occur. Native American populations have unique outdoor cultural and occupational practices that may impact their exposure to ticks, yet this risk remains understudied in the context of TBD. To address this gap, we examined knowledge, attitudes, and practices regarding ticks and TBDs among Native American communities in Humboldt County, California. We conducted semi-structured interviews with participants, who represented various tribes, at a cultural gathering. Cultural practices intertwined closely with outdoor activities (e.g., ceremonies, dances), potentially influencing local tick exposure patterns. Most research participants had been bitten by ticks and reported tick exposure by children and pets. Research participants demonstrated low knowledge about ticks and TBDs, as well as low levels of risk perceptions pertaining to TBDs. Research participants most commonly conducted tick checks after outdoor activity, wore long-sleeved clothing outdoors, and used homeopathic remedies or essential oils to prevent exposure to ticks and TBDs. Culturally appropriate outreach and education initiatives are needed to address TBD risk among Native American communities. Our study lays the groundwork for future research on the intersection of cultural practices and tick exposure, with implications for public health interventions that are tailored to the needs of indigenous populations.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"20 ","pages":"Article 100976"},"PeriodicalIF":4.1,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11787543/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a zoonotic influenza distribution assessment and ranking system (ZIDAR): Technical application in Nepal to support cross-sectoral risk-based surveillance","authors":"Adam Charette-Castonguay ,&nbsp;Dipendra Gautam ,&nbsp;Binay Shrestha ,&nbsp;Hemant Chandra Ojha ,&nbsp;Barun Kumar Sharma ,&nbsp;Mukul Upadhayaya ,&nbsp;Sujan Rana ,&nbsp;Roshika Shrestha ,&nbsp;Lok Bandu Chaudhary ,&nbsp;Bhawana Kandel ,&nbsp;Rudra Prasad Marasini ,&nbsp;Sharmila Chapagain ,&nbsp;Tulsi Ram Gompo ,&nbsp;Surendra Karki ,&nbsp;Apsara Poudel ,&nbsp;Saugat Shrestha ,&nbsp;Avinash Sunny Kayastha ,&nbsp;Arun Kumar Govindakarnavar ,&nbsp;Reuben Samuel ,&nbsp;Allison Gocotano ,&nbsp;Ricardo J. Soares Magalhães","doi":"10.1016/j.onehlt.2025.100975","DOIUrl":"10.1016/j.onehlt.2025.100975","url":null,"abstract":"<div><div>Zoonotic influenza poses a significant public health concern to agricultural industries, food security, wildlife conservation, and human health. Nations situated along migratory bird flyways and characterised by dense populations of livestock and humans, and low biosecurity of production animal value chains are particularly vulnerable to zoonotic influenza outbreaks. While spatial risk assessments have been used to map vulnerable areas, their applicability across multiple sectors has been so far limited. Here, we introduce the development and application of a Zoonotic Influenza Distribution and Ranking (ZIDAR) framework to identify areas highly suitable for zoonotic influenza transmission across multiple exposure interfaces and to measure the importance of associated risk factors. The development of ZIDAR involves a seven-step approach distributed across an initial expert consultation stage followed by a technical modelling stage. The expert consultation stage aims to define interfaces of exposure across human, livestock and wildlife, identification of associated risk factors for each of the identified interfaces and a prioritisation activity to define weights for the interfaces and associated risk factors. This is then followed by a technical phase involving model building, model structure validation, data gathering and assessment of model performance. The model development and performance assessment steps of the technical stage includes a model calibration step to maximise model fitness with regards to wildlife and animal interfaces by finding pareto-efficient sets of weights for risk factors. We applied the ZIDAR framework in Nepal and the resulting model structure enabled the identification of hotspot areas where the risk of transmission is more significant across multiple interfaces simultaneously. The ZIDAR Nepal model's predictive accuracy, determined by the area under the receiver operating characteristic curve, demonstrated strong performance: 0.87 and 0.85 for the wildlife and animal components, respectively. The ZIDAR framework presented here provides valuable insights to enable the formulation of comprehensive One Health surveillance programs and inform targeted and effective interventions to bolster pandemic preparedness strategies.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"20 ","pages":"Article 100975"},"PeriodicalIF":4.1,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143174832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular assessment of oyster microbiomes and viromes reveals their potential as pathogen and ecological sentinels","authors":"Jordan R. Walker ,&nbsp;Dennis A. Bente ,&nbsp;Megan T. Burch ,&nbsp;Filipe M. Cerqueira ,&nbsp;Ping Ren ,&nbsp;Jessica M. Labonté","doi":"10.1016/j.onehlt.2025.100973","DOIUrl":"10.1016/j.onehlt.2025.100973","url":null,"abstract":"<div><div>Oyster aquaculture world-wide is a booming industry that can provide many benefits to coastal habitats, including economic, ecosystem-level, and cultural benefits. Oysters present several risks for human consumption, including transmission of parasites, and bacterial and viral pathogens. Oyster microbiomes are well-defined, but their connection to the incidence of pathogens, humans or others, is unclear. Furthermore, viruses associated with oysters are largely unknown, and their connection to humans, animals, and ecosystem health has not been explored. Here, we employed a One Health framework and modern molecular techniques, including 16S rRNA amplicon and metagenomic sequencing, to identify links between changes in the microbial and viral communities associated with oysters and the incidence of pathogens detected in oyster tissues and their surrounding environments. In addition, we adapted the BioFire® FilmArray®, commonly used in hospitals, to determine the presence of human pathogens within the sampled oysters. We detected known human pathogens in 50 % of the oysters tested. Within the genomic datasets, we noted that pathogens of humans, animals, and plants in oysters were shared with the nearby water and sediments, suggesting a sink–source dynamic between the oysters and their surroundings. 16S rRNA gene analysis revealed that while oysters share common microbial constituents with their surrounding environments, they enrich for certain bacteria such as Mycoplasmatales, Fusobacteriales, and Spirochaetales. On the contrary, we found that oyster viromes harbored the same viruses in near equal relative abundances as their surrounding environments. Our results show how oysters could be used not only to determine the risk of human pathogens within coastal estuaries but also how oyster viruses could be used as ecosystem-level sentinels.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"20 ","pages":"Article 100973"},"PeriodicalIF":4.1,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11786891/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monitoring for respiratory viruses among wild canids, Texas","authors":"Lyudmyla V. Marushchak ,&nbsp;Laura A. Pulscher ,&nbsp;Judith U. Oguzie ,&nbsp;Diego B. Silva ,&nbsp;Kenneth A. Waldrup ,&nbsp;Douglas M. Watts ,&nbsp;Gregory C. Gray","doi":"10.1016/j.onehlt.2025.100974","DOIUrl":"10.1016/j.onehlt.2025.100974","url":null,"abstract":"<div><div>The cross-species transmission of respiratory viruses such as SARS-CoV-2 and avian influenza underscores the need for novel respiratory virus surveillance at the human-animal interface. In this 2023 pilot study we examined oral and rectal swab samples from 15 deceased wild animals for novel respiratory viruses. We used virus molecular techniques, culture and next-generation nucleotide sequencing to search for and characterize viruses in the <em>Coronaviridae</em> and <em>Orthomyxoviridae</em> families. Through these activities we detected and characterized one canine coronaviruses (CCoVs) each from a gray fox (<em>Urocyon cinereorgenteus</em>) and a feral dog (<em>Canis lupus familiaris</em>). The gray fox CCoV sequence clustered with other CCoVs reported in other canids from other regions of the world. The feral dog CCoV sequence was closely related to CCoVs reported in Brazil and the United Kingdom. This pilot study demonstrated the usefulness of a noninvasive monitoring approach in detecting and characterizing respiratory viruses among wild canids.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"20 ","pages":"Article 100974"},"PeriodicalIF":4.1,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11787532/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genomic and resistome analysis of Salmonella enterica isolates from retail markets in Yichun city, China","authors":"Xiaowu Jiang ,&nbsp;Abubakar Siddique ,&nbsp;Li Chen ,&nbsp;Lexin Zhu ,&nbsp;Haiyang Zhou ,&nbsp;Li Na ,&nbsp;Chenghao Jia ,&nbsp;Yan Li ,&nbsp;Min Yue","doi":"10.1016/j.onehlt.2025.100967","DOIUrl":"10.1016/j.onehlt.2025.100967","url":null,"abstract":"<div><div>Nontyphoidal <em>Salmonella</em> (NTS) causes global outbreaks of foodborne disease. The main source of <em>Salmonella</em> for humans is animal-borne foods; however, the monitoring of <em>Salmonella</em> in the food chain via genomic platforms was limited in China. This study evaluated the prevalence, resistome, and virulome diversity of <em>Salmonella</em> strains identified from pork, retail environment, aquatic products, and poultry eggs of retail markets in Yichun city, Jiangxi province. The overall incidence of <em>Salmonella</em> was 9.4 %, with a higher contamination rate observed in pork at 13.5 %, followed by the retail environment at 7.69 %. The genomic analysis of the isolates revealed a total of fifteen distinct serovars, with serovar Enteritidis being the most prevalent (64.3 %). The phenotypic resistance analysis conducted by the broth microdilution method, revealed that 81.12 % of the isolates exhibited multidrug resistance (MDR), with high resistance to trimethoprim/sulphonamides (100 %), followed by tetracycline (99.3 %) and streptomycin (99.3 %). Genotypic analysis of antimicrobial resistance identified 80 antimicrobial-resistant genes (ARGs), with <em>mdf(A)</em>, <em>aph(3′)-Ib</em>, <em>tet(A)</em>, <em>dfrA12</em>, <em>floR</em>, <em>bla</em>_{<em>TEM-1B</em>}, <em>qnrS3</em>, and <em>sul2,</em> conferring resistance to different antimicrobial classes, being the predominant ARGs. Additionally, forty ESBL genes, particularly critical genes such as <em>bla</em>_CTX-M and <em>bla</em>_NDM-1, were also identified in <em>Salmonella</em> isolates. The <em>IncR</em>, <em>IncFIB (K)</em>, and <em>IncX1</em> plasmid replicons were widely prevalent and served as significant reservoirs of horizontally acquired foreign genes. Moreover, key virulence genes such as <em>cdtB</em>, <em>lpf</em> and <em>sef</em> were also detected, in addition to <em>Salmonella</em> pathogenicity islands SPI-1 and SPI-2. This study reveals the prevalence of multidrug-resistant and virulent strains of <em>Salmonella</em> serovars in the markets of Yichuan city, posing a risk of human infections. The gained knowledge provided essential baseline information that may be utilized for regular tracking of MDR <em>Salmonella</em> transmission in the food chain to minimize potential future outbreaks.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"20 ","pages":"Article 100967"},"PeriodicalIF":4.1,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143175760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subtle genomic differences in Klebsiella pneumoniae sensu stricto isolates indicate host adaptation","authors":"Bridget O'Brien ,&nbsp;Alla Yushchenko ,&nbsp;Jinha Suh ,&nbsp;Dongyun Jung ,&nbsp;Zhangbin Cai ,&nbsp;Ngoc Sang Nguyen ,&nbsp;Makeda Semret ,&nbsp;Simon Dufour ,&nbsp;Séamus Fanning ,&nbsp;Jennifer Ronholm","doi":"10.1016/j.onehlt.2025.100970","DOIUrl":"10.1016/j.onehlt.2025.100970","url":null,"abstract":"<div><div><em>Klebsiella pneumoniae sensu stricto</em> (KpI) is an opportunistic pathogen capable of residing as a commensal in both human and bovine intestinal tracts and can cause serious systemic infections in humans and severe clinical mastitis in dairy cattle. It is unclear what role zoonotic and anthroponotic transmission play in the dissemination of KpI. In this study, we use a comparative genomic approach to identify differences between KpI associated with disease in humans and cattle and aimed to identify any potential genetic barriers limiting transmission of KpI between these two hosts. A total of 128 KpI strains (bovine <em>n</em> = 65; human <em>n</em> = 63) were whole genome sequenced and human and bovine strains were compared based on phylogenomics, the pangenome, mobile genetic elements, and differential gene abundance. No obvious phylogenomic differentiation was observed between isolates from these hosts. However, subtle genetic differences exist between bovine and human KpI which likely reflect environmental adaptation to different host niches, including a higher representation of gene clusters encoding ferric citrate uptake transporters, as well as histidine, arginine, and lactose utilization pathways in bovine isolates. These gene clusters may be positively selected due to the unique metabolic environment of the mammary gland, where lactose, citrate-bound iron, and amino acids like histidine and arginine provide growth advantages for KpI during mastitis. Overall, our study identified no obvious genetic barriers to zoonotic transmission of KpI within the dairy environment and provides insight into the development of host-specific therapeutic options for KpI infections in humans and bovine.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"20 ","pages":"Article 100970"},"PeriodicalIF":4.1,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11787494/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and antimicrobial resistance of Campylobacter jejuni and Campylobacter coli over time in Thailand under a One Health approach: A systematic review and meta-analysis","authors":"Doan Hoang Phu ,&nbsp;Tuempong Wongtawan ,&nbsp;Truong Thanh Nam ,&nbsp;Dinh Bao Truong ,&nbsp;Naparat Suttidate ,&nbsp;Juan Carrique-Mas ,&nbsp;Niwat Chansiripornchai ,&nbsp;Conny Turni ,&nbsp;Patrick J. Blackall ,&nbsp;Thotsapol Thomrongsuwannakij","doi":"10.1016/j.onehlt.2025.100965","DOIUrl":"10.1016/j.onehlt.2025.100965","url":null,"abstract":"<div><div><em>Campylobacter</em> spp. are major food-borne zoonotic pathogens impacting food safety worldwide. Thailand is one of the countries facing with a significant burden of <em>Campylobacter</em> infections and is recognized as a hotspot of AMR. Our study applied a systematic review and meta-analysis, using a One Health perspective, to investigate the prevalence and AMR of <em>Campylobacter jejuni</em> (<em>C. jejuni</em>) and <em>Campylobacter coli</em> (<em>C. coli</em>) over time in Thailand, from 1985 to 2023. Based on the PRISMA guidelines, a literature search using PubMed, ScienceDirect, and Google Scholar to identify the articles reporting prevalence, sequence types (STs), antimicrobial susceptibility, and resistance genes of <em>Campylobacter</em> spp. in humans, animals, food, and environmental samples was performed. Eighty-one articles were retrieved for systematic review, with 33 reporting <em>Campylobacter</em> spp. prevalence and 20 containing AMR data collected for meta-analysis. The highest prevalence of <em>C. jejuni</em> was found in chickens (43.6 %) and chicken products (31.4 %), followed by ducks (16.7 %), the general human population with diarrhea (15.9 %), children with diarrhea (10.7 %). <em>C. coli</em> was also prevalent in chickens (12.6 %) and chicken products (10.4 %). <em>C. jejuni</em> prevalence decreased by 14.8 % among children with diarrhea (<em>p</em> = 0.006), but increased by 16.7 % in chicken products (<em>p</em> = 0.007). Sixty-two STs were identified, with ST 574, ST 1075, ST 51 being the most prevalent STs recorded. Five STs, including ST 50, ST 51, ST 354, ST 464, and ST 574, were reported in both humans and chickens. The AMR levels were highest against quinolones, ranging 75.4 %–94.8 % in human-related categories and 71.6 %–88.7 % in chicken-related categories. Notably, ciprofloxacin-resistant and nalidixic acid-resistant <em>C. jejuni</em> strains collected from chickens increased by 11.9 % (<em>p</em> = 0.004) and 16.1 % (<em>p</em> = 0.027), respectively. Thirteen resistance genes/mutations were reported, with the phenotypic resistance linked to <em>gyrA</em> mutations and <em>tet</em>(O) genes. The high prevalence and increasing trend of AMR in <em>C. jejuni</em> and <em>C. coli</em> underscore the critical need for One Health surveillance to address the rising AMR challenge posed by these pathogens in Thailand.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"20 ","pages":"Article 100965"},"PeriodicalIF":4.1,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11782884/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}