Ophthalmology. Retina最新文献

{"title":"Exploring Clinical Features of Polypoidal Choroidal Vasculopathy in Black Patients","authors":"Adam Lazrak MD,&nbsp;Martin Bonnafous MD,&nbsp;Albert Jean-Charles MD,&nbsp;Katia Ouamrane MD,&nbsp;Alizée Tabouillot MD,&nbsp;Yanice Chaoui-Boudghane MD,&nbsp;Harold Merle MD, PhD","doi":"10.1016/j.oret.2025.02.030","DOIUrl":"10.1016/j.oret.2025.02.030","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to evaluate the clinical and angiographic presentation of polypoidal choroidal vasculopathy (PCV) in a large cohort of Black patients.</div></div><div><h3>Design</h3><div>We conducted a descriptive cross-sectional analysis.</div></div><div><h3>Participants</h3><div>Out of 283 patients followed for PCV in our department, 167 cases were confirmed by indocyanine green angiography (ICGA). The remaining patients lacked ICGA imaging. Among the 167 confirmed cases, 57 patients were excluded due to significant ophthalmological comorbidities, leaving 160 affected eyes in 110 patients for analysis.</div></div><div><h3>Methods</h3><div><span>We reviewed the most recent retinophotography, OCT, </span>fluorescein<span>, and ICGA images in our database. All analyzed patients were followed and underwent their examinations at the University Hospital Center of Martinique, a referral center in Fort de France primarily serving a Black population. An exploratory analysis of choroidal features was made in those who underwent enhanced depth imaging spectral-domain OCT. In parallel, a literature review on PCV was performed to contextualize our findings.</span></div></div><div><h3>Main Outcome Measures</h3><div>We measured visual acuity, sex ratio, patient age, characteristics of exudative phenomena, polyp location, and PCV type according to Kawamura classification.</div></div><div><h3>Results</h3><div>Most patients were women (62.7%), with an average age of 72.2 ± 10.1 years. Among the 160 eyes, 81.9% exhibited idiopathic type 2 PCV and 52.4% showed peripapillary polyp distribution. The mean visual acuity<span> was 0.29 ± 0.3 logarithm of the minimum angle of resolution. Soft drusen were present in 15% of eyes, and 44.5% of patients had bilateral involvement. Black patients seem to have distinctive PCV characteristics compared with other ethnic groups, with a low incidence of macular polyps (23.1%), a high incidence of peripapillary polyps (52.4%), and high incidence of bilateral involvement (42.8%).</span></div></div><div><h3>Conclusions</h3><div><span>This is the largest series of Afro-descendant patients with PCV ever described in the literature. Polypoidal choroidal vasculopathy in our population is primarily type 2 PCV according to Kawamura's classification, predominantly affecting women, often bilateral, with a preferentially extramacular location of the polyps. These observations may be explained by the fact that PCV in these patients is not the result of neovascularization but rather linked to a generalized disease of the </span>choroid, such as pachychoroid.</div></div><div><h3>Financial Disclosure(s)</h3><div>The authors have no proprietary or commercial interest in any materials discussed in this article.</div></div>","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":"9 9","pages":"Pages 860-869"},"PeriodicalIF":5.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Telescreening for Retinopathy of Prematurity after 40 Weeks Postmenstrual Age","authors":"Daanyal Raja ,&nbsp;Cindy S. Zhao MD, MBA ,&nbsp;Sarthak V. Shah BS ,&nbsp;Saeed Mohammadi MD ,&nbsp;Arthur R. Brant MD ,&nbsp;Darius M. Moshfeghi MD","doi":"10.1016/j.oret.2025.03.025","DOIUrl":"10.1016/j.oret.2025.03.025","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":"9 9","pages":"Pages 921-923"},"PeriodicalIF":5.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intravitreal Silicone Oil Bubbles after Perforating Needlestick Open-Globe Injury","authors":"Taariq K. Mohammed MD,&nbsp;Jonathan F. Russell MD, PhD","doi":"10.1016/j.oret.2025.01.009","DOIUrl":"10.1016/j.oret.2025.01.009","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":"9 9","pages":"Page e88"},"PeriodicalIF":5.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-Funduscopic Slit Lamp Assessment of the Posterior Hyaloid Membrane","authors":"Shefali Sood MD ,&nbsp;Talha A. Barra MBBS ,&nbsp;Ryan T. Duong MD ,&nbsp;Imran A. Khatri MD ,&nbsp;Mohammed K. Barazi MD ,&nbsp;Michael H. Osman MD ,&nbsp;Abdullah Abou-Samra MD ,&nbsp;Jeanette Du MD ,&nbsp;Hamza A. Lateef ,&nbsp;Jason Mingyi Huang MD ,&nbsp;Claudia G. Hooten MD ,&nbsp;Brian K. Do MD ,&nbsp;Joshua D. Levinson MD ,&nbsp;Alexander Melamud MA, MD ,&nbsp;Mariam Mathai MD ,&nbsp;Mohsin H. Ali MD","doi":"10.1016/j.oret.2025.02.027","DOIUrl":"10.1016/j.oret.2025.02.027","url":null,"abstract":"<div><h3>Purpose</h3><div>To assess the clinical utility of a simpler method of detecting a complete posterior vitreous detachment<span> (PVD)—visualization of the posterior hyaloid membrane at the slit lamp—which does not require expert dilated fundus examination skills, special instrumentation (fundoscopy lenses), or imaging devices (OCT or B-scan).</span></div></div><div><h3>Design</h3><div>Cross-sectional case series.</div></div><div><h3>Participants</h3><div>All eligible patients presenting to the retina clinic during the study period were consecutively examined.</div></div><div><h3>Methods</h3><div>All patients were examined for the presence or absence of a PVD using the posterior hyaloid membrane assessment method and Weiss ring assessment method and via OCT performed by 3 masked graders.</div></div><div><h3>Main Outcome Measures</h3><div>The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), receiver operator curves, and areas under the curve (AUC) were analyzed to assess the clinical utility of the 2 methods.</div></div><div><h3>Results</h3><div>A total of 206 eyes of 118 patients were included. The incidence of true PVDs based on OCT was 57.3%. The posterior hyaloid assessment method was more sensitive than the Weiss ring assessment method (89.8% vs. 79.7%; <em>P</em> = 0.04) and had a higher NPV (87.5% vs. 78.2%; <em>P</em> &lt; 0.01). There was no significant difference in specificity between the posterior hyaloid membrane and Weiss ring methods (95.5% vs. 97.4%; <em>P</em> = 0.5) or PPV (96.4% vs. 97.3%; <em>P</em> = 0.2). The AUC for the posterior hyaloid assessment and Weiss ring methods were 0.93 and 0.89, respectively (chi-square = 2.84; <em>P</em> value = 0.09).</div></div><div><h3>Conclusions</h3><div>This study shows that this method of assessing the posterior hyaloid status is clinically meaningful and has a high sensitivity, specificity, PPV, NPV, and AUC. Compared with the Weiss ring method, the posterior hyaloid membrane assessment has a significantly higher sensitivity and NPV and a similarly high specificity, PPV, and AUC. Although trainees are not regularly taught this diagnostic skill, these results support that visualizing and assessing the posterior hyaloid membrane should be in every ophthalmologist’s diagnostic skill repertoire.</div></div><div><h3>Financial Disclosure(s)</h3><div>Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.</div></div>","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":"9 9","pages":"Pages 892-898"},"PeriodicalIF":5.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral Choroidal Melanocytosis","authors":"Sylvia Nghiem-Buffet MD ,&nbsp;Salomon Y. Cohen MD, PhD","doi":"10.1016/j.oret.2025.02.007","DOIUrl":"10.1016/j.oret.2025.02.007","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":"9 9","pages":"Page e92"},"PeriodicalIF":5.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk and Dose–Response Relationship for Pentosan Polysulfate Sodium Maculopathy","authors":"Brendan K. Tao MD ,&nbsp;Korolos Sawires BPharm ,&nbsp;Kate Lim PharmD ,&nbsp;Fahad Butt HBSc ,&nbsp;Thanansayan Dhivagaran HBSc ,&nbsp;Rudra Rishi Gupta MD ,&nbsp;Amit Mishra MD","doi":"10.1016/j.oret.2025.03.001","DOIUrl":"10.1016/j.oret.2025.03.001","url":null,"abstract":"<div><h3>Topic</h3><div>To determine the pooled relative risk (RR) of pentosan polysulfate sodium maculopathy (PPSM) in patients using pentosan polysulfate sodium (PPS) and model the dose–response relationship of this association from existing literature.</div></div><div><h3>Clinical Relevance</h3><div>Pentosan polysulfate sodium maculopathy is an acquired, progressive retinal pigmentary disease associated with oral PPS use. Although several observational studies suggest a dose–response relationship of this association, to date, there remains no literature-pooled synthesis on the risk of PPSM across strata of cumulative dose.</div></div><div><h3>Methods</h3><div>Systematic review and meta-analysis (CRD42024623179). Medline, Embase, and Cochrane Central Register of Controlled Trials were searched from inception to September 15, 2024. We included studies reporting the incidence of PPS-associated maculopathy and including cumulative PPS dose information. Two independent reviewers completed study screening, data extraction, and risk of bias (ROB) assessment using the ROB in nonrandomized studies of exposures tool, and a third reviewer was consulted to resolve conflicts. The primary outcome was the RR of PPSM among patients exposed to PPS compared with nonexposed individuals, stratified by cumulative PPS dose.</div></div><div><h3>Results</h3><div>We included 5 studies encompassing 141 785 patients and 6432 PPSM cases. The linear dose–response regression model estimated a 0.1% increase in RR of maculopathy per g increase in cumulative PPS dose (log-transformed RR = 0.00101; 95% confidence interval, 0.0005–0.0015; <em>P</em> &lt; 0.0001). Patients with cumulative doses ≥2000 g exhibited an RR of 7.39 (95% confidence interval, 4.17–13.10), while those with a dose between 1 and 500 g had an RR of 1.65 (95% confidence interval, 1.12–2.43) compared with nonexposed individuals. Subgroup analysis excluding high-risk studies demonstrated consistent findings, with reduced heterogeneity (I² = 63.7%).</div></div><div><h3>Conclusion</h3><div>Moderate certainty evidence supports a dose-dependent relationship between PPS exposure and PPSM risk, whereas higher cumulative doses significantly increase maculopathy risk. This result supports that patients should be tapered to an effective minimal dose and that they should be subject to interval maculopathy screening, especially for patients with greater cumulative dose. Future research should incorporate patient-level data to better control for potential confounding.</div></div><div><h3>Financial Disclosure(s)</h3><div>The authors have no proprietary or commercial interest in any materials discussed in this article.</div></div>","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":"9 9","pages":"Pages 870-882"},"PeriodicalIF":5.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143616649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Age-Related Macular Degeneration and Mortality in a High Cardiovascular Risk Cohort","authors":"Richard Kha MD ,&nbsp;George Burlutsky MAppStat ,&nbsp;Aravinda Thiagalingam PhD ,&nbsp;Pramesh Kovoor PhD ,&nbsp;Joseph Chiha PhD ,&nbsp;Paul Mitchell PhD ,&nbsp;Gerald Liew PhD","doi":"10.1016/j.oret.2025.02.024","DOIUrl":"10.1016/j.oret.2025.02.024","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate whether age-related macular degeneration (AMD) predicts the risk of all-cause and cardiovascular disease (CVD) mortality in a high CVD risk cohort.</div></div><div><h3>Design</h3><div>Prospective cohort study.</div></div><div><h3>Participants</h3><div>A total of 1545 adult participants who presented to a tertiary Australian hospital for evaluation of acute coronary syndrome were included in this study.</div></div><div><h3>Methods</h3><div><span>Participants were evaluated for acute coronary syndrome using </span>coronary angiography<span><span>. Participants were concurrently examined for AMD from mydriatic<span><span> fundus photographs, which were graded using the Wisconsin grading system into categories of any AMD, early AMD, and late AMD. </span>Coronary artery disease was graded from coronary angiograms using the </span></span>Gensini score<span>. Mortality data were obtained 9 years after baseline examination through data linkage with the Australian National Death Index. Hazard ratios (HRs) were obtained using Cox regression analysis.</span></span></div></div><div><h3>Main Outcome Measures</h3><div>All-cause and CVD mortality data were obtained through data linkage with the Australian National Death Index. Death rates through June 2018 were compared by demographics and potential confounders.</div></div><div><h3>Results</h3><div>Any AMD was identified in 107 (6.9%) participants, including those with early (n = 86) and late AMD (n = 21). Over 9 years of follow-up, 234 (15.1%) participants had died, including 174 (11.3%) participants from fatal CVD events. After controlling for age, sex, body mass index<span>, total cholesterol, smoking status, history of diabetes, hypertension, myocardial infarction, stroke, and macrovascular coronary artery disease severity using the Gensini score, there was an increased rate of all-cause mortality for those with any AMD (HR, 2.37; 95% confidence interval [CI], 1.54–3.64), early AMD (HR, 2.42; 95% CI, 1.48–3.94), and late AMD (HR, 2.25; 95% CI, 1.08–4.71). Any AMD (HR, 2.62; 95% CI, 1.61–4.26) and early AMD (HR, 2.61; 95% CI, 1.50–4.64) were also associated with a greater likelihood of CVD mortality. Late AMD was not associated with CVD mortality.</span></div></div><div><h3>Conclusions</h3><div>In individuals with high CVD risk, the presence of AMD at any stage independently predicted increased all-cause mortality. Meanwhile, any AMD and early AMD increased the risk of CVD mortality. Although mechanisms are unclear, this potentially reflects shared pathways between AMD and CVD.</div></div><div><h3>Financial Disclosure(s)</h3><div>The authors have no proprietary or commercial interest in any materials discussed in this article.</div></div>","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":"9 9","pages":"Pages 821-827"},"PeriodicalIF":5.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extensive Myelinated Nerve Fibers in a Case of Straatsma Syndrome","authors":"Gulshan Barwar DNB, DOMS","doi":"10.1016/j.oret.2025.01.005","DOIUrl":"10.1016/j.oret.2025.01.005","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":"9 9","pages":"Page e87"},"PeriodicalIF":5.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rhegmatogenous Retinal Detachment Hiding an Underlying Choroidal Melanoma","authors":"Gabrielle E. Kozlowski BS,&nbsp;Hidayet Sener MD,&nbsp;Carol L. Shields MD","doi":"10.1016/j.oret.2025.01.018","DOIUrl":"10.1016/j.oret.2025.01.018","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":"9 9","pages":"Page e89"},"PeriodicalIF":5.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spontaneous Remodeling of Abnormal Choroidal Vasculature","authors":"Eliza Anthony MBBS, DNB,&nbsp;Jefila Jayakumar MBBS, DNB,&nbsp;Prabu Baskaran MBBS, MS","doi":"10.1016/j.oret.2025.01.003","DOIUrl":"10.1016/j.oret.2025.01.003","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":"9 9","pages":"Page e85"},"PeriodicalIF":5.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}