Ophthalmology. Retina最新文献

{"title":"Fungal Endogenous Endophthalmitis Presenting as Posterior Hypopyon.","authors":"Sarang Gupta, Arpitha Kalava, Bhavik Panchal","doi":"10.1016/j.oret.2024.12.025","DOIUrl":"https://doi.org/10.1016/j.oret.2024.12.025","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inadvertent Intralenticular Bevacizumab Injection.","authors":"Alexander M Rusakevich, Jennifer P Tingley, Kareem Moussa","doi":"10.1016/j.oret.2024.12.024","DOIUrl":"https://doi.org/10.1016/j.oret.2024.12.024","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Foveal Cavitations by High-resolution OCT after Acute Macular Neuroretinopathy.","authors":"Lorenzo Ferro Desideri, Martin Zinkernagel, Rodrigo Anguita","doi":"10.1016/j.oret.2024.12.022","DOIUrl":"https://doi.org/10.1016/j.oret.2024.12.022","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Baseline Vision on Outcomes in Diabetic Macular Edema in VISTA/VIVID.","authors":"Michael A Singer, Dilraj S Grewal, Preston O'Brien, Fabiana Silva, Weiming Du, Guruprasad B, Hadi Moini, Mark R Barakat","doi":"10.1016/j.oret.2025.01.016","DOIUrl":"10.1016/j.oret.2025.01.016","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143256313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Features of Valsalva-Induced Choroidal Hemorrhage in High Myopia","authors":"Livia Faes MD , Alessandro Feo MD , Jiwei Sheng MD , Prithvi Ramtohul MD , Bradley S. Gundlach MD , J. Michael Jumper MD , David Sarraf MD , K. Bailey Freund MD","doi":"10.1016/j.oret.2024.10.021","DOIUrl":"10.1016/j.oret.2024.10.021","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":"9 2","pages":"Pages 194-196"},"PeriodicalIF":4.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142546608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence, Features, and Outcomes of Type 1 Neovascularization in Eyes with Angioid Streaks","authors":"Maria Vittoria Cicinelli MD ,&nbsp;Prithvi Ramtohul MD ,&nbsp;Lorenzo Bianco MD ,&nbsp;Ugo Introini MD ,&nbsp;Francesco Bandello MD ,&nbsp;K. Bailey Freund MD ,&nbsp;Maurizio Battaglia Parodi MD","doi":"10.1016/j.oret.2024.08.002","DOIUrl":"10.1016/j.oret.2024.08.002","url":null,"abstract":"<div><h3>Purpose</h3><div>This study aimed to delineate the characteristics, prevalence, and outcomes of neovascularization (NV), particularly aneurysmal type 1 NV, in patients with angioid streaks (AS) secondary to pseudoxanthoma elasticum (PXE), and to introduce a clinical classification based on multimodal imaging.</div></div><div><h3>Design</h3><div>Retrospective longitudinal cohort study.</div></div><div><h3>Participants</h3><div>Eighty-five patients (168 eyes) with AS secondary to PXE at 2 tertiary referral centers.</div></div><div><h3>Methods</h3><div>Data collection included demographic, medical, and ocular histories. Diagnostic methods comprised fundus photography, autofluorescence, indocyanine green angiography, OCT, and OCT angiography.</div></div><div><h3>Main Outcome Measures</h3><div>Prevalence of type 1 NV, visual acuity (VA), risk of exudation.</div></div><div><h3>Results</h3><div>Type 1 NV was identified in 127 eyes (76%), with 85 of these (67%) showing exclusively type 1 NV. These lesions often originated around the disc, at sites of Bruch membrane dehiscences, and followed the path of AS, extending to the macula in 101 eyes (80%). Despite 65% of type 1 NV remaining nonexudative, 35% evolved into exudative over 5 years, and 11 eyes experienced midperipheral subretinal hemorrhages. Aneurysmal dilations, observed in 57% of eyes, substantially increased exudation risk (hazard ratio = 3.86, <em>P</em> = 0.02). Despite treatment, VA significantly deteriorated in exudative type 1 NV (<em>P</em> = 0.02). Type 2 NV, detected in 42 eyes (33%), often coexisted with type 1 NV and was associated with poorer visual outcomes and higher rates of macular atrophy. A classification of AS was developed, ranging from empty AS (stage 0, no NV) to advanced NV (stage 3, both type 1 and type 2 NV).</div></div><div><h3>Conclusions</h3><div>Type 1 NV predominates in AS. Although predominantly nonexudative, its progression correlates with substantial visual impairment, similar to the deficits observed with type 2 NV. Aneurysmal type 1 NV poses a significant exudation risk, underscoring the need for vigilant monitoring.</div></div><div><h3>Financial Disclosure(s)</h3><div>Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.</div></div>","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":"9 2","pages":"Pages 166-179"},"PeriodicalIF":4.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141913628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adenoma of the Retinal Pigment Epithelium Arising from Congenital Hypertrophy","authors":"Alexandra Thaler BA,&nbsp;Thomas M. Catapano BS,&nbsp;Carol L. Shields MD","doi":"10.1016/j.oret.2024.06.014","DOIUrl":"10.1016/j.oret.2024.06.014","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":"9 2","pages":"Page e10"},"PeriodicalIF":4.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141634148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subretinal Emulsified Silicone Oil in Rhegmatogenous Retinal Detachment","authors":"Lumin Liang MD ,&nbsp;Nan Zhou MD, PHD ,&nbsp;Wenbin Wei PhD","doi":"10.1016/j.oret.2024.07.007","DOIUrl":"10.1016/j.oret.2024.07.007","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":"9 2","pages":"Page e16"},"PeriodicalIF":4.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142006265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Neighborhood Socioeconomic Disadvantage with Proliferative Diabetic Retinopathy","authors":"Wendy Yangyiran Xie BS ,&nbsp;Zainab Rustam MBBS ,&nbsp;Diep Tran MS ,&nbsp;Dingfen Han PhD ,&nbsp;Mozhdeh Bahrainian MD ,&nbsp;Roomasa Channa MD ,&nbsp;Cindy X. Cai MD, MS","doi":"10.1016/j.oret.2024.10.012","DOIUrl":"10.1016/j.oret.2024.10.012","url":null,"abstract":"<div><h3>Purpose</h3><div>To evaluate the association between neighborhood socioeconomic deprivation, distance from ophthalmology clinics, and diagnosis of proliferative diabetic retinopathy (PDR).</div></div><div><h3>Design</h3><div>Retrospective cohort study.</div></div><div><h3>Participants</h3><div>Adult patients (≥18 years) with diabetes mellitus at Johns Hopkins Hospital and University of Wisconsin–Madison.</div></div><div><h3>Methods</h3><div>Patient addresses were geocoded and the block group was linked to the 2021 national Area Deprivation Index (ADI). Area Deprivation Index was divided into quartiles, with higher quartiles indicating greater socioeconomic disadvantage. The distance between patient’s residence and ophthalmology clinics was calculated. Multivariable logistic regression models were used to analyze the association between ADI quartile, distance from clinic, and PDR, adjusted for demographics and insurance status. The interaction between ADI and distance was tested.</div></div><div><h3>Main Outcome Measures</h3><div>Diagnosis of PDR.</div></div><div><h3>Results</h3><div>A total of 73 618 patients were included. A significant interaction was observed between ADI quartile and distance from ophthalmology clinics (<em>P</em> &lt; 0.001). Among patients residing within 8 miles of clinics, those in higher ADI quartiles had increased odds of PDR compared with those in ADI Q1 (Q2: odds ratio [OR], 1.36; 95% confidence interval [CI], 1.12–1.65; Q3: OR, 1.79; 95% CI, 1.46–2.19; Q4: OR, 2.60; 95% CI, 2.09–3.25; <em>P</em> &lt; 0.001 for trend). Conversely, for patients living more than 8 miles from clinics, the odds of PDR were similar across ADI quartiles (Q1: OR, 0.85; 95% CI, 0.73–0.98; Q2: OR, 1.02; 95% CI, 0.87–1.12; Q3: OR, 1.08; 95% CI, 0.90–1.30). However, patients in all ADI quartiles more than 8 miles had greater odds of PDR compared with those in the same ADI quartile within 8 miles (OR, 3.15; 95% CI, 2.61–3.80; OR, 1.97; 95% CI, 1.71–2.27; OR, 1.79; 95% CI, 1.51–2.12; and OR, 1.31; 95% CI, 1.07–1.61 in ADI Q1–Q4, respectively).</div></div><div><h3>Conclusions</h3><div>Patients living in neighborhoods with greater socioeconomic disadvantage and farther from ophthalmology clinics have greater odds of PDR. These findings suggest the potential utility of targeted interventions in socioeconomically deprived and distant areas to reduce PDR-related blindness.</div></div><div><h3>Financial Disclosure(s)</h3><div>Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.</div></div>","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":"9 2","pages":"Pages 98-104"},"PeriodicalIF":4.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142471482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endophthalmitis in Eyes Treated with the Port Delivery System with Ranibizumab","authors":"David A. Eichenbaum MD ,&nbsp;William R. Freeman MD ,&nbsp;Margaret A. Chang MD, MS ,&nbsp;Logan Brooks MD ,&nbsp;Nauman Chaudhry MD ,&nbsp;Hajir Dadgostar MD, PhD ,&nbsp;Colin A. McCannel MD ,&nbsp;Mark Michels MD ,&nbsp;Robert A. Mittra MD ,&nbsp;Jeremy D. Wolfe MD, MS ,&nbsp;Victoria C. Beindl MS ,&nbsp;Philip Jaycock FRCOphth, MD ,&nbsp;Ashwini Bobbala MS ,&nbsp;Shamika Gune MD, MS ,&nbsp;Galin Spicer MD, MBA ,&nbsp;Natalia Callaway MD, MS","doi":"10.1016/j.oret.2024.08.005","DOIUrl":"10.1016/j.oret.2024.08.005","url":null,"abstract":"<div><h3>Purpose</h3><div>The Port Delivery System with ranibizumab (PDS) is approved in the United States for neovascular age-related macular degeneration. The United States Prescribing Information has a Boxed Warning for endophthalmitis and reports the incidence rate in patients developing endophthalmitis after receiving the PDS compared with monthly intravitreal ranibizumab. Endophthalmitis cases noted in the Boxed Warning, treatment outcomes, potential contributing factors, and potential mitigations are summarized.</div></div><div><h3>Design</h3><div>Retrospective review of endophthalmitis cases in PDS-treated patients in the phase II Ladder (NCT02510794) and phase III Archway (NCT03677934) and Portal (NCT03683251) trials.</div></div><div><h3>Participants</h3><div>Endophthalmitis cases in the pooled all-PDS safety population (N = 555) including PDS patients in Ladder, Archway, or Portal.</div></div><div><h3>Methods</h3><div>Ladder patients received PDS (10, 40, or 100 mg/ml) with pro re nata refill-exchanges. Archway patients received PDS 100 mg/ml with fixed refill-exchanges every 24 weeks (PDS Q24W). Portal patients received PDS Q24W from day 1.</div></div><div><h3>Main Outcome Measures</h3><div>Clinical features, management, and visual outcomes were summarized. Cases were summarized by date of PDS implant and/or refill, other prior invasive procedures/refills, and preceding/concurrent conjunctival complications.</div></div><div><h3>Results</h3><div>Twelve endophthalmitis events were reported in 11 patients (11/555 [2.0%]) through March 12, 2021. All were cultured (3 were culture positive) and treated with intravitreal antibiotics. Two cases (2/555 [0.4%]) occurred in the immediate postoperative period (days 5 and 6). Nine cases occurred later (day range: 57–853), including 4 before the first refill-exchange (day range: 57–161). Five patients received between 1 and 11 refill-exchanges before the event (onset: 6–168 days after last refill-exchange). Seven cases (7/11 [63.6%]) had preceding/concurrent conjunctival complications. At last follow-up, 7 patients recovered vision to study baseline levels or ≥20/40; 4 patients experienced vision loss of ≥15 ETDRS letters.</div></div><div><h3>Conclusions</h3><div>Endophthalmitis is a serious complication that can endanger vision after any ocular procedure, including PDS implantation. Most, but not all, of this limited series of endophthalmitis cases were late onset, associated with conjunctival breach, and recovered vision with treatment. Meticulous attention to PDS surgical techniques with vigilant monitoring of conjunctiva during follow-up may minimize risk of endophthalmitis. Prompt treatment is critical for optimizing patient outcomes.</div></div><div><h3>Financial Disclosure(s)</h3><div>Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.</div></div>","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":"9 2","pages":"Pages 127-143"},"PeriodicalIF":4.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142000440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}