Ophthalmology. Retina最新文献

Epstein–Barr Virus Lymphoproliferative Disorder in a Patient with Acute Lymphoblastic Leukemia 急性淋巴细胞白血病患者的Epstein-Barr病毒淋巴增生性疾病

IF 5.7

Ophthalmology. Retina Pub Date : 2025-10-01 DOI: 10.1016/j.oret.2025.02.026

Lydia Zhong BA, Michael Ip MD, Kirk K. Hou MD, PhD

引用次数: 0

Subhyaloid Air Bubble Post Intravitreal Injection 玻璃体内注射后的玻璃体下气泡。

IF 5.7

Ophthalmology. Retina Pub Date : 2025-10-01 DOI: 10.1016/j.oret.2025.02.014

Mariana Vaz MD , Ana Mafalda Pereira MD , Diogo Cabral MD

引用次数: 0

Drug-Induced Vasculitis and Choroiditis after Brolucizumab 单抗后药物性血管炎和脉络膜炎。

IF 5.7

Ophthalmology. Retina Pub Date : 2025-10-01 DOI: 10.1016/j.oret.2025.05.020

Andrea Servillo MD , Maria Vittoria Cicinelli MD , Cecilia Mularoni MD , Carlo La Spina MD , Francesco Bandello MD , Elisabetta Miserocchi PhD, MD

引用次数: 0

Retinitis Pigmentosa with Preserved Para-arteriolar Retinal Pigment Epithelium 保留动脉旁视网膜色素上皮的色素性视网膜炎。

IF 5.7

Ophthalmology. Retina Pub Date : 2025-10-01 DOI: 10.1016/j.oret.2025.02.019

Zehao Liu MD, Xinyu Liu MD, Ying Lin MD, PhD

引用次数: 0

Endophthalmitis Incidence after Intravitreal Injection of Anti-VEGF Agents with Povidone-Iodine versus Aqueous Chlorhexidine Antisepsis 玻璃体内注射抗vegf药物与聚维酮碘与氯己定水消毒后眼内炎的发生率。

IF 5.7

Ophthalmology. Retina Pub Date : 2025-10-01 DOI: 10.1016/j.oret.2025.03.022

Brandon Bates MD, John Fitzpatrick MD, Caroline Rosanky BA, Jared Moon MD, Edward Wood MD, Philip Storey MD, MPH

{"title":"Endophthalmitis Incidence after Intravitreal Injection of Anti-VEGF Agents with Povidone-Iodine versus Aqueous Chlorhexidine Antisepsis","authors":"Brandon Bates MD, John Fitzpatrick MD, Caroline Rosanky BA, Jared Moon MD, Edward Wood MD, Philip Storey MD, MPH","doi":"10.1016/j.oret.2025.03.022","DOIUrl":"10.1016/j.oret.2025.03.022","url":null,"abstract":"<div><h3>Purpose</h3><div><span>To evaluate the incidence of postinjection endophthalmitis (PIE) after </span>intravitreal injection<span> (IVI) of anti-VEGF agents in eyes prepared with topical 5% povidone-iodine (PI) or 0.05% aqueous chlorhexidine (AqCHX) as antisepsis.</span></div></div><div><h3>Design</h3><div>Retrospective, single-center, comparative cohort study.</div></div><div><h3>Participants</h3><div>Individuals who received ≥1 intravitreal anti-VEGF injection with use of PI or AqCHX as antisepsis.</div></div><div><h3>Methods</h3><div>For all patients receiving intravitreal anti-VEGF injections at Austin Retina Associates between March 1, 2015 and November 1, 2023, all injections and cases of suspected PIE were identified with billing codes and confirmed with review of electronic medical record data. Eyes that presented after injection with pain or decreased vision warranting treatment with intravitreal antibiotics were considered suspected PIE cases. Eyes were grouped based on preparation with PI or AqCHX.</div></div><div><h3>Main Outcome Measures</h3><div>The primary outcomes were incidence of suspected and culture-positive PIE and visual acuity (VA) at 3 months postendophthalmitis.</div></div><div><h3>Results</h3><div>A total of 302 474 IVIs were administered during the study period. Within the PI group, 59 cases of suspected PIE occurred after 267 190 injections (0.022%; 1 in 4529 injections) compared with 5 cases after 35 284 injections (0.014%; 1 in 7057 injections) in the AqCHX group (<em>P</em> = 0.34). For the PI group, there were 10 culture-positive PIE cases (0.0037%, 1 in 26 719 injections) compared with 0 cases in the AqCHX group (<em>P</em> = 0.25). At 3 months postinfection, average VA in the PI group was 0.97 (∼20/200) and 1.4 (∼20/500) in the AqCHX group (<em>P</em> = 0.41). When controlling for prefilled syringe status, there was no difference in rates of PIE between antisepsis groups (<em>P</em> = 0.23).</div></div><div><h3>Conclusions</h3><div>The incidence of endophthalmitis after IVI is low, with no difference in the rates of infection with eyes prepared with topical PI compared with AqCHX. Topical AqCHX has similar efficacy to PI for the prevention of endophthalmitis after IVI.</div></div><div><h3>Financial Disclosure(s)</h3><div>Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.</div></div>","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":"9 10","pages":"Pages 928-933"},"PeriodicalIF":5.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Guidelines for the Diagnosis, Management, and Study of Autoimmune Retinopathy from the American Academy of Ophthalmology's Task Force 美国眼科学会工作组的自身免疫性视网膜病变诊断、管理和研究指南。

IF 5.7

Ophthalmology. Retina Pub Date : 2025-10-01 DOI: 10.1016/j.oret.2025.03.024

Bobeck S. Modjtahedi MD , Alan G. Palestine MD , Lee M. Jampol MD , David Sarraf MD , H. Nida Sen MD, MHS , Lucia Sobrin MD, MPH , John J. Chen MD, PhD , Paul Yang MD, PhD , Grazyna Adamus PhD , Donald S. Fong MD, MPH , Cynthia X. Qian MD , Flora Lum MD

{"title":"Guidelines for the Diagnosis, Management, and Study of Autoimmune Retinopathy from the American Academy of Ophthalmology's Task Force","authors":"Bobeck S. Modjtahedi MD , Alan G. Palestine MD , Lee M. Jampol MD , David Sarraf MD , H. Nida Sen MD, MHS , Lucia Sobrin MD, MPH , John J. Chen MD, PhD , Paul Yang MD, PhD , Grazyna Adamus PhD , Donald S. Fong MD, MPH , Cynthia X. Qian MD , Flora Lum MD","doi":"10.1016/j.oret.2025.03.024","DOIUrl":"10.1016/j.oret.2025.03.024","url":null,"abstract":"<div><h3>Purpose</h3><div>The American Academy of Ophthalmology<span> created a Task Force to advance the understanding of autoimmune retinopathy (AIR) and provided guidelines on the diagnosis and management of this complex disorder.</span></div></div><div><h3>Design</h3><div>A search on PubMed and Google Scholar of English-language studies was conducted without date restrictions. The Task Force reviewed the current literature and formulated an expert consensus on the management of AIR as well as recommendations for future efforts to improve our understanding of this condition.</div></div><div><h3>Results</h3><div>Key clinical and imaging features are discussed, and a new diagnostic framework is proposed based on the likelihood of AIR (probable AIR, possible AIR, and unlikely AIR) to provide a more standardized approach for categorizing disease. Patients who possess all the following features can be categorized as having probable AIR: (1) signs of disease progression<span><span><span> based on subjective symptoms and objective testing within 6 months; (2) examination with <1+ anterior chamber cells, vitreous cells, or vitreous haze; (3) </span>OCT<span> with outer retinal disruption and loss of the external limiting membrane/outer retinal bands/ellipsoid zone often relatively sparing the fovea; (4) characteristic fundus autofluorescence abnormalities; (5) full-field electroretinogram (ERG) with reduction of both rod and cone responses; and (6) positive antiretinal antibodies. Those with some but not all of these features, or with otherwise atypical presentations, can be classified as possible AIR. Features that would make AIR unlikely and should elicit strong suspicion for alternative diagnoses are as follows: (1) slowly progressive symptoms or changes on testing taking place over the years; (2) </span></span>retinal examination<span><span> with bone spicules, retinal vascular sheathing, or retinal hemorrhages; (3) examination with >1+ anterior chamber cells, vitreous cells, or vitreous haze; (4) OCT changes predominantly at the level of the </span>retinal pigment epithelium<span> (RPE) or areas of focal/sharply delineated outer retinal/RPE atrophy; (5) fluorescein angiography<span> with diffuse retinal vasculitis or large areas of nonperfusion; or (6) a normal full-field ERG (even with an abnormal multifocal ERG).</span></span></span></span></div></div><div><h3>Conclusions</h3><div>These criteria will allow for better classification of patients reported in the literature and improve communication between clinicians. Further study is necessary to optimize the approach for managing AIR and will require collaborative multicenter efforts.</div></div><div><h3>Financial Disclosure(s)</h3><div>Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.</div></div>","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":"9 10","pages":"Pages 1005-1016"},"PeriodicalIF":5.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spontaneous Peeling of the Internal Limiting Membrane during Epiretinal Membrane Surgery 视网膜外膜手术中内限制膜自发剥离：来自剥离临床试验的经验教训。

IF 5.7

Ophthalmology. Retina Pub Date : 2025-10-01 DOI: 10.1016/j.oret.2025.04.015

Yannick Eude MD , Alexandra Poinas PhD , Christelle Volteau , Olivier Lebreton MD , Alexandre Bonissent MD , Paul Fossum MD , Catherine Creuzot-Garcher MD, PhD , Yannick Le Mer MD , Julien Perol MD , June Fortin MSc , Alexandra Jobert PhD , Fanny Billaud OD , Catherine Ivan RN , Michel Weber MD, PhD , Jean-Baptiste Ducloyer MD, PhD

{"title":"Spontaneous Peeling of the Internal Limiting Membrane during Epiretinal Membrane Surgery","authors":"Yannick Eude MD , Alexandra Poinas PhD , Christelle Volteau , Olivier Lebreton MD , Alexandre Bonissent MD , Paul Fossum MD , Catherine Creuzot-Garcher MD, PhD , Yannick Le Mer MD , Julien Perol MD , June Fortin MSc , Alexandra Jobert PhD , Fanny Billaud OD , Catherine Ivan RN , Michel Weber MD, PhD , Jean-Baptiste Ducloyer MD, PhD","doi":"10.1016/j.oret.2025.04.015","DOIUrl":"10.1016/j.oret.2025.04.015","url":null,"abstract":"<div><h3>Purpose</h3><div>The aim of this study was to identify predictive factors for spontaneous internal limiting membrane (ILM) peeling after idiopathic unilateral epiretinal membrane (ERM) removal and to compare outcomes between patients with and without spontaneous ILM peeling.</div></div><div><h3>Design</h3><div>The PEELING study was a national randomized clinical trial.</div></div><div><h3>Participants</h3><div>Patients with symptomatic idiopathic ERM were recruited from 5 ophthalmology departments.</div></div><div><h3>Interventions</h3><div>Vitrectomy and ERM dissection were performed. When the ILM spontaneously peeled off over an area of at least 2 optic disc diameters around the fovea, patients were not randomized and were included in the spontaneous ILM peeling group (SPG). Otherwise, patients were randomized intraoperatively to either the no ILM peeling group (NPG) or the active ILM peeling group (APG).</div></div><div><h3>Main Outcome Measures</h3><div>Microperimetry, best-corrected visual acuity (BCVA) measurements, and OCT findings were assessed at month 1 (M1), M6, and M12. The primary outcome was the difference in microscotoma number between baseline and M6.</div></div><div><h3>Results</h3><div>Of 213 patients, 101 experienced spontaneous ILM peeling and 100 were randomized (APG, n = 51 and NPG, n = 49). In the SPG, 99 patients were included in the baseline characteristics analysis and 75 patients were included in the follow-up characteristics analysis. Baseline characteristics were similar between all groups. The difference in microscotoma number between baseline and M6 was not statistically significant between groups (−4.8 ± 9.9 in NPG, −2.2 ± 7.3 in APG, and −2.7 ± 6.9 in SPG). At M1, the difference in microscotoma number was significantly higher in the APG (+1.6 ± 8.9) than in the SPG (−1.6 ± 6.2, <em>P</em> < 0.001) and NPG (−2.1 ± 10.2, <em>P</em> = 0.006). The BCVA was significantly better in the SPG than in the APG at M1 (<em>P</em> < 0.01) and M6 (<em>P</em> = 0.03) and in the NPG at M6 (<em>P</em> < 0.01) and M12 (<em>P</em> = 0.01). The anatomical ERM recurrence rate was lower in the SPG (4%, n = 3) than in the NPG (19.6%, n = 9 and <em>P</em> = 0.0096) but similar between the SPG and APG (0%). Two patients in the NPG underwent revision surgery.</div></div><div><h3>Conclusions</h3><div>The difference in microscotoma number between baseline and M6 was not statistically significant between groups. Spontaneous ILM peeling was common and associated with better clinical outcomes. No predictive factors were identified.</div></div><div><h3>Financial Disclosure(s)</h3><div>Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.</div></div>","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":"9 10","pages":"Pages 934-942"},"PeriodicalIF":5.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143991691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of Proliferative Vitreoretinopathy in Rhegmatogenous Retinal Detachment with OCT 利用OCT评估孔源性视网膜脱离的增生性玻璃体视网膜病变：重述1991年视网膜学会分类。

IF 5.7

Ophthalmology. Retina Pub Date : 2025-10-01 DOI: 10.1016/j.oret.2025.04.017

Isabela Martins Melo MD , Aurora Pecaku MD , Saba Samet MD , Paola Oquendo MD , Marko M. Popovic MD , Sue Ellen Demian MD , Miguel Cruz-Pimentel MD , Rajeev H. Muni MD, MSc

{"title":"Assessment of Proliferative Vitreoretinopathy in Rhegmatogenous Retinal Detachment with OCT","authors":"Isabela Martins Melo MD , Aurora Pecaku MD , Saba Samet MD , Paola Oquendo MD , Marko M. Popovic MD , Sue Ellen Demian MD , Miguel Cruz-Pimentel MD , Rajeev H. Muni MD, MSc","doi":"10.1016/j.oret.2025.04.017","DOIUrl":"10.1016/j.oret.2025.04.017","url":null,"abstract":"<div><h3>Purpose</h3><div>To characterize proliferative vitreoretinopathy (PVR) with swept-source OCT (SS-OCT) in rhegmatogenous retinal detachment (RRD).</div></div><div><h3>Design</h3><div>Prospective cross sectional cohort study.</div></div><div><h3>Subjects</h3><div>Consecutive primary RRDs presenting to St. Michael’s Hospital from 2021 to 2023.</div></div><div><h3>Methods</h3><div>Ultra-widefield fundus imaging was staged per the Retina Society 1991 PVR Classification and correlated with retinal microstructural changes assessed with SS-OCT.</div></div><div><h3>Main Outcome Measures</h3><div>Swept-source OCT findings in PVR.</div></div><div><h3>Results</h3><div>One hundred patients were included. Patients with no signs of PVR or PVR A (49/100) were more likely to have a preserved bacillary layer on SS-OCT with low-amplitude outer retinal corrugations (ORCs) compared with the PVR B/C group. Proliferative vitreoretinopathy B (retinal wrinkling/vessel tortuosity) was present in 24% (24/100) of cases, all of which had high-amplitude ORCs. Proliferative vitreoretinopathy C (27/100) was clinically divided into patients with subretinal (SR) membranes (63% [17/27]) and patients with fixed retinal folds (intraretinal [IR]) (37% [10/27]). The SR subtype was associated with slowly progressive detachments. On SS-OCT, they had a thick hyperreflective membrane emanating from the retinal pigment epithelium and extending along the outer retinal surface, causing tractional folds of the outer retina in 47% (8/17) of cases and tractional bacillary layer detachment in 12% (2/17) of cases. Outer retinal thinning/atrophy was commonly observed in the SR subtype. Patients with the IR subtype had rapidly progressive detachments on fundus examination and extensive IR changes on SS-OCT. These had a thickened bacillary layer with high-amplitude ORCs with photoreceptor-photoreceptor apposition within or between individual corrugations (fused ORCs). Significant preretinal membranes with loss of differentiation of the inner and outer retinal lamellae and distortion of underlying ORCs were observed.</div></div><div><h3>Conclusions</h3><div>Our study demonstrates imaging evidence of varying PVR morphology. The IR subtype occurs in rapidly progressive detachments with intrinsic retinal changes that span from fused and distorted corrugations to retinal thickening, preretinal membranes, and loss of differentiation of retinal lamella. The SR subtype occurs in slowly progressive detachments, where the proliferation is associated with membranes emanating from the retinal pigment epithelium, outer retinal thinning/atrophy, and tractional outer retinal folds. We present a novel OCT classification of primary PVR, which varies based on RRD morphology. Pathological photoreceptor apposition in fused ORCs may be associated with glial proliferation and corresponding IR and preretinal changes.</div></div><div><h3>Financial Disclosure(s)</h3><div>Proprietary or commercial disclosure may be ","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":"9 10","pages":"Pages 943-954"},"PeriodicalIF":5.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144003407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retinal Detachment and Macular Hole in Acute Retinal Necrosis Treated with Human Amniotic Membrane 人羊膜治疗急性视网膜坏死视网膜脱离及黄斑孔。

IF 5.7

Ophthalmology. Retina Pub Date : 2025-10-01 DOI: 10.1016/j.oret.2025.02.012

Federica Fossataro MD , Salvatore Parrulli MD , Matteo Giuseppe Cereda MD

引用次数: 0

Tumor Localization with Indirect Ophthalmoscopy Transillumination 间接眼镜透视下的肿瘤定位。

IF 5.7

Ophthalmology. Retina Pub Date : 2025-10-01 DOI: 10.1016/j.oret.2025.02.008

Gabriela Mousse de Carvalho MD , João Victor Notini Arcanjo MD , Zelia Maria Corrêa MD, PhD

引用次数: 0