Ophthalmology. Retina最新文献

{"title":"Arteriovenous Malformation with Central Retinal Vein Occlusion and Intraretinal Hyporeflective Spaces.","authors":"Andrea Coletto, Valerie Krivosic, Elodie Bousquet","doi":"10.1016/j.oret.2025.04.018","DOIUrl":"https://doi.org/10.1016/j.oret.2025.04.018","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144160722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and Multimodal Imaging of Acute Outer Retinopathy Expanding the Spectrum of Acute Annular Outer Retinopathy.","authors":"Prithvi Ramtohul, Maria Vittoria Cicinelli, Fred K Chen, Daniel J Oh, Benjamin D Freilich, Michael A Singer, Matthew J Hartley, Jyotirmay Biswas, Etienne Boulanger, Kunho Bae, Hun Young Lim, Tharikarn Sujirakul, Pierre Gascon, Kevin J Blinder, Christine Fardeau, Sasa Pockar, Sofia Androudi, Hiroyuki Nakashizuka, Yorihisa Kitagawa, Ari Shinojima, Elisabetta Miserocchi, K Bailey Freund","doi":"10.1016/j.oret.2025.05.027","DOIUrl":"https://doi.org/10.1016/j.oret.2025.05.027","url":null,"abstract":"<p><strong>Purpose: </strong>To describe the clinical features, multimodal imaging findings, natural history, and treatment outcomes of acute outer retinopathy (AOR), which represents an expanded spectrum of acute annular outer retinopathy (AAOR).</p><p><strong>Design: </strong>Retrospective, observational, longitudinal, multicenter case series.</p><p><strong>Participants: </strong>Twenty-three patients (15 female, 8 male) with a mean age of 41.8 ± 18.6 years (range: 14-86 years) and a mean follow-up duration of 3.7 ± 1.5 years (range: 1-12 years).</p><p><strong>Methods: </strong>Clinical characteristics, multimodal imaging findings, laboratory evaluations, genetic testing, natural history, therapeutic management, and outcomes were reviewed and analyzed.</p><p><strong>Main outcomes measures: </strong>Specific multimodal imaging signatures of AOR were identified, including findings from ophthalmoscopy, fundus autofluorescence (FAF), fluorescein angiography (FA), indocyanine green angiography (ICGA), and optical coherence tomography (OCT). Humphrey visual field testing, full-field electroretinography (ERG), and multifocal ERG were analyzed. Baseline features and the natural course of the disease were delineated.</p><p><strong>Results: </strong>Thirty-eight eyes from 23 patients were analyzed. Presenting symptoms included photopsia (87%), blurred vision (57%), and scotoma (57%). On ophthalmoscopy, AOR was acutely characterized by yellow-greyish outer retinal lesions corresponding to hyperautofluorescent changes on FAF and the angular sign of Henle fiber layer hyperreflectivity (ASHH) on OCT. FAF imaging revealed ring-like hyperautofluorescent lesions surrounding the optic disc in 18% of eyes. Additional lesion patterns on FAF included perivenular (53%), sectoral (16%), and spot-like distributions (13%). FA and ICGA findings were mostly unremarkable. Lesion progression primarily occurred within the initial weeks following presentation and stabilized in size beyond this period in the majority of eyes. Over time, affected areas progressed to outer retinal atrophy with pigmentary changes. Foveal sparing was observed in 68% of the eyes. None of the therapeutic interventions appeared effective in halting the progression to complete outer retinal atrophy or preventing lesion enlargement.</p><p><strong>Conclusions: </strong>AOR is characterized by early photoreceptor disruption, evidenced by ASHH on OCT, leading to rapid outer retinal atrophy and subsequent degeneration of the retinal pigment epithelium within the damaged zones. Although distinct patterns of lesion distribution were observed, their consistent features on multimodal imaging support their inclusion within a unified disease spectrum termed acute outer retinopathy.</p>","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Timing of Retinopathy of Prematurity Diagnosis and Treatment in Micro-Premature and Nano-Premature Infants During Inpatient Screening.","authors":"Melissa Yuan, Francisco Altamirano, Daniel Hu, Sandra Hoyek, Celine Chaaya, Muhammad Abidi, Hanna De Bruyn, Anne Fulton, Iason S Mantagos, Carolyn Wu, Efren Gonzalez, Deborah K VanderVeen, Ryan Gise, Nimesh A Patel","doi":"10.1016/j.oret.2025.05.026","DOIUrl":"https://doi.org/10.1016/j.oret.2025.05.026","url":null,"abstract":"<p><strong>Objective: </strong>We aimed to determine the timing of retinopathy of prematurity (ROP) diagnosis and treatment in a cohort of infants meeting criteria for micro and/or nano-prematurity with the goal of informing screening protocols in this high-risk group.</p><p><strong>Design: </strong>Retrospective consecutive study.</p><p><strong>Participants: </strong>We included all screened infants who met the criteria for micro-prematurity (24-26 weeks GA and/or BW 600-799 grams) or nano-prematurity (<24 weeks GA and/or BW <600 grams).</p><p><strong>Methods: </strong>Data collected from 2013 to 2023 included GA at birth, BW, postmenstrual age (PMA) at ROP diagnosis, PMA at type 1 ROP diagnosis, and number of inpatient examinations.</p><p><strong>Main outcomes measures: </strong>Rates of ROP and treatment-warranted ROP, timing to first ROP diagnosis and treatment-warranted ROP, and the number of examinations.</p><p><strong>Results: </strong>3239 infants were screened during this time period for ROP, and 650 infants met inclusion criteria. The median GA at birth and BW were 25.3 weeks and 682.5 grams, respectively. 456 infants (70.2%) were micro-premature and 194 (29.8%) were nano-premature. ROP was detected in 524 patients (80.6%). The median PMA at first ROP diagnosis was 33.7 weeks. The median interval from birth to first ROP diagnosis was 8.4 weeks. The median exam number at first ROP diagnosis was the second exam. The median number of inpatient examinations was 9. Of ROP patients, 180 (34.4%) had ROP diagnosis at their first examination. A total of 126 (19.4% of all infants and 24.0% of those with ROP) infants met type 1 treatment criteria. The median PMA at type 1 ROP diagnosis was 37 weeks . The median interval from birth to type 1 ROP was 12 weeks. The median exam number at type 1 diagnosis was the 5th exam.</p><p><strong>Conclusions: </strong>In this modern cohort of high-risk extremely premature infants, 9 patients (1.4%) were diagnosed with type 1 ROP on the first or second inpatient exams. These infants had generally good outcomes after treatment, with only two eyes of one patient progressing to stage 4 disease. Our findings support maintaining current screening guidelines for high-risk extremely premature infants, while suggesting opportunities for optimizing screening approaches through risk stratification.</p>","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: Tsai et al.: Clinical characteristics and treatment outcomes in unilateral Coats disease: a global collaborative study (Ophthalmol Retina. 2025;9:570-579).","authors":"Saarang Hansraj, Vishal Raval","doi":"10.1016/j.oret.2025.04.008","DOIUrl":"https://doi.org/10.1016/j.oret.2025.04.008","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: Griffin et al.: Pneumatic Retinopexy for Rhegmatogenous Retinal Detachment Outcomes: IRIS® Registry (Intelligent Research in Sight) Analysis (Ophthalmol Retina. 2025;9:437-443).","authors":"Fernando J Huelin, Peter J Kertes, Roxane J Hillier","doi":"10.1016/j.oret.2025.04.012","DOIUrl":"https://doi.org/10.1016/j.oret.2025.04.012","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply.","authors":"Shane Griffin, Lawrence Chan, Kayne McCarthy, Xuan Peng, Charles Li, Linda D Harrison, Flora Lum, Gaurav Shah","doi":"10.1016/j.oret.2025.04.011","DOIUrl":"https://doi.org/10.1016/j.oret.2025.04.011","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply.","authors":"Andrew S H Tsai, Chung-Ting Wang, Wei-Chi Wu","doi":"10.1016/j.oret.2025.04.009","DOIUrl":"https://doi.org/10.1016/j.oret.2025.04.009","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregnancy and Diabetic Retinopathy: A Report From the All of Us Research Program.","authors":"Shahin Hallaj, Muhammad Z Chauhan, Ahmed F Shakarchi, Paul H Phillips, Ahmed B Sallam","doi":"10.1016/j.oret.2025.05.021","DOIUrl":"https://doi.org/10.1016/j.oret.2025.05.021","url":null,"abstract":"<p><p>In this cross sectional observational study, pregnancy was not associated with higher non-proliferative diabetic retinopathy or proliferative diabetic retinopathy prevalence.</p>","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144120468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: Griffin et al.: Pneumatic retinopexy for rhegmatogenous retinal detachment outcomes: IRIS Registry (Intelligent Research in Sight) analysis (Ophthalmol Retina. 2025;9:437-443).","authors":"Andrew Mihalache, Marko M Popovic, Rajeev H Muni","doi":"10.1016/j.oret.2025.04.010","DOIUrl":"https://doi.org/10.1016/j.oret.2025.04.010","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug-induced Vasculitis and Choroiditis after Brolucizumab.","authors":"Andrea Servillo, Maria Vittoria Cicinelli, Cecilia Mularoni, Carlo La Spina, Francesco Bandello, Elisabetta Miserocchi","doi":"10.1016/j.oret.2025.05.020","DOIUrl":"https://doi.org/10.1016/j.oret.2025.05.020","url":null,"abstract":"<p><p>This study reports two cases of drug-induced immune-mediated retinal vasculopathy and choroiditis following intravitreal brolucizumab, highlighting its clinical features, severity, and irreversibility, emphasizing vigilant monitoring and multidisciplinary management to prevent vision-threatening complications.</p>","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}