Ophthalmology. Retina最新文献

{"title":"Longitudinal Changes in Inner Retinal Layers in Treatment-Naïve Neovascular AMD During Intravitreal Anti-VEGF Therapy.","authors":"Helin Kardo, Richard A Garweg, Lars Imbach, Justus G Garweg","doi":"10.1016/j.oret.2026.08.031","DOIUrl":"https://doi.org/10.1016/j.oret.2026.08.031","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate longitudinal changes in retinal nerve fiber layer (RNFL) and ganglion cell- inner plexiform layer (GC-IPL) thickness in treatment-naïve neovascular age-related macular degeneration (nAMD) under intravitreal anti-VEGF therapy (IVT), compared with untreated fellow eyes with dry AMD (dAMD).</p><p><strong>Design: </strong>Retrospective single-center cohort study.</p><p><strong>Subjects: </strong>Consecutive patients with treatment-naïve nAMD receiving anti-VEGF therapy under a treat-and-extend regimen and a minimum follow-up of 24 months were included. Untreated fellow eyes with dAMD served as controls.</p><p><strong>Methods: </strong>RNFL and GC-IPL thickness were assessed longitudinally using spectral-domain optical coherence tomography and RetinAI analysis. Best-corrected visual acuity (BCVA) and structural retinal changes were evaluated over time. Linear mixed-effects models were used to assess factors associated with retinal layer changes.</p><p><strong>Main outcome measures: </strong>Longitudinal changes in RNFL thickness, GC-IPL thickness, and BCVA.</p><p><strong>Results: </strong>In nAMD eyes, median RNFL thickness in the 3 mm ring zone decreased from 32.3 μm (30.1-35.4) at baseline to 30.9 μm (29.0-33.4; adjusted P < .001) after the loading phase and remained stable thereafter (all adjusted P > .05), with a similar pattern observed in fellow dAMD eyes. In contrast, GC-IPL thickness progressively declined in both groups. In nAMD eyes, median GC-IPL thickness decreased from 89.1 μm (81.9-94.9) at baseline to 85.1 μm (77.7-90.2) after loading (adjusted P < .001), followed by continued thinning throughout follow-up. BCVA in nAMD eyes improved after loading with a median gain of 4.8 ETDRS letters (0-10.2; adjusted P < .001), remained stable for up to 3 years, and gradually declined thereafter. Mixed-effects modeling showed RNFL thickness was associated with injection number, whereas GC-IPL loss was associated with age and follow-up duration, independent of injection number or sex.</p><p><strong>Conclusions: </strong>The regression in RNFL and GC-IPL thickness during the loading phase in eyes with nAMD may reflect the resolution of pre-treatment swelling. RNFL thickness remained stable thereafter, while GC-IPL thickness and BCVA declined after loading similarly to fellow eyes with dAMD. According to the mixed-effects model, GC-IPL thinning appears linked to progression of the underlying degenerative process, whereas RNFL thickness appears comparatively preserved.</p>","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148892169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GLP1-RA Use and Risk of Non-arteritic Anterior Ischemic Optic Neuropathy in Patients with Type 2 Diabetes.","authors":"Jessica J Lee, Todd Brothers, Leo A Kim, Kristina E Ward, Hafizan Yusuf, Xuerong Wen","doi":"10.1016/j.oret.2026.08.029","DOIUrl":"https://doi.org/10.1016/j.oret.2026.08.029","url":null,"abstract":"<p><strong>Importance: </strong>Concerns have been raised regarding the increased risk of non-arteritic ischemic optic neuropathy (NAION) associated with the use of glucagon-like peptide 1 receptor agonist (GLP-1 RA). However, findings remain inconsistent due to differences in indications for drug use, comparator groups, follow-up periods, and study populations.</p><p><strong>Objective: </strong>This study aims to examine the association between GLP-1 RA use and the risk of NAION among U.S. patients with type 2 diabetes mellitus (T2DM) enrolled in private health plans.</p><p><strong>Design, setting, and participants: </strong>This retrospective cohort study was conducted based on health administrative claims data from 2012 to 2024. Target trial emulation was applied, using a new user design and active comparators, to compare the risk of NAION between patients initiating GLP-1 RAs and those initiating sodium-glucose cotransporter-2 inhibitors (SGLT-2i) or dipeptidyl peptidase-4 inhibitors (DPP-4i). Propensity score methods were utilized to balance baseline demographic and clinical characteristics between the comparison groups. Cox proportional hazard models were applied to estimate adjusted hazard ratios (HR) of NAION incidence associated with GLP-1 RAs, relative to SGLT-2i or DPP-4i.</p><p><strong>Exposures: </strong>Participants initiating GLP-1 RAs compared with those initiating SGLT-2i or DPP-4i for the treatment of T2DM.</p><p><strong>Main outcomes and measures: </strong>Incidence of NAION in the comparison groups and the adjusted hazard ratios between groups.</p><p><strong>Results: </strong>A total of 19,505 adult patients diagnosed with T2DM were included, with 9,213 (47.2%) using GLP-1 RAs, 10,292 (52.8%) exposed to SGLT-2i or DPP-4i, and 29 incidences of NAION. Compared with SGLT-2i or DPP-4i, overall GLP-1 RA use was not significantly associated with a higher risk of NAION (HR: 1.87; 95%CI: 0.85-4.12). However, risk of NAION among liraglutide users was higher than for SGLT-2i or DPP-4i users within 12 or 18 months of follow-up. Additionally, the elevated risk of NAION associated with GLP-1 RAs relative to SGLT-2i or DPP-4i was observed in males and older adults.</p><p><strong>Conclusions and relevance: </strong>Our findings indicate that GLP-1 RA use, particularly liraglutide, may be associated with an increased risk of NAION among patients with T2DM. Further research is warranted to confirm these findings and clarify the biological mechanisms linking GLP-1 RA use to NAION.</p>","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148888212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence and Consensus Based Imaging Guidelines in Ocular Toxoplasmosis. Multimodal imaging in Uveitis (MUV) Taskforce Report 14.","authors":"Andrea Trinco, Alessandro Invernizzi, Alejandra de-la-Torre, Daniel Vasconcelos-Santos, Radgonde Amer, Ariel Schlaen, Manisha Agarwal, Jeanette Ossewaarde Von Norel, Aniruddha Agarwal, Sapna Gangaputra, Rupesh Agrawal, Douglas A Jabs, Marc D de Smet, Carlos Pavesio, Janet L Davis, Massimo Accorinti, David Sarraf, Vishali Gupta","doi":"10.1016/j.oret.2026.08.026","DOIUrl":"https://doi.org/10.1016/j.oret.2026.08.026","url":null,"abstract":"<p><strong>Purpose: </strong>To develop imaging and consensus-based guidelines for the application of multimodal imaging in ocular toxoplasmosis (OT).</p><p><strong>Design: </strong>International expert consensus study using the nominal group technique (NGT) guided by systematic literature review.</p><p><strong>Participants: </strong>International uveitis specialists and retina experts participating in the Multimodal Imaging in Uveitis (MUV) taskforce.</p><p><strong>Methods: </strong>A subgroup of experts reviewed the published literature on imaging in OT, along with complete multimodal imaging datasets from cases fulfilling the Standardized Uveitis Nomenclature (SUN) criteria. Imaging modalities included color fundus photography (CFP), optical coherence tomography (OCT), fundus autofluorescence (FAF), fundus fluorescein angiography (FFA), indocyanine green angiography (ICGA), and OCT angiography (OCTA). NGT sessions were conducted to identify key imaging features of typical and atypical presentations of active and inactive OT across modalities and to define imaging findings associated with disease-related complications. Consensus-based imaging descriptors and practical imaging guidelines were developed through iterative discussion. The proposed guidelines were voted on by the MUV taskforce.</p><p><strong>Main outcome measures: </strong>Identification of multimodal imaging features of active and inactive OT and development of imaging guidelines for diagnosis, activity assessment, and detection of complications.</p><p><strong>Results: </strong>The experts agreed that classic OT remains primarily a clinical diagnosis. CFP was considered sufficient for diagnosing typical active OT presenting as focal or paucifocal necrotizing retinochoroiditis. OCT provided important information on lesion depth, retinal and choroidal involvement, and vitreoretinal interface abnormalities, and was particularly valuable in atypical presentations and for longitudinal disease monitoring. FAF assisted in staging lesion evolution and identifying MEWDS-like reactions. FA and ICGA were not recommended for routine use but suggested in selected cases to evaluate the presence and extent of complications. OCTA was considered sufficient for detecting choroidal neovascularization in most cases. Multimodal imaging was generally recommended for atypical OT and for assessment of complications.</p><p><strong>Conclusions: </strong>The consensus-based imaging guidelines by MUV provide a standardized and pragmatic framework for the use of multimodal imaging in OT. While the diagnosis in typical cases remains largely clinical, as outlined in the SUN classification, OCT and FAF are valuable for monitoring disease activity, and additional imaging modalities support the management of atypical presentations and complications.</p>","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148881321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraocular Solitary Fibrous Tumor","authors":"Yang Meng MD,&nbsp;Sainan Xiao MD, PhD,&nbsp;Tao Li MD, PhD","doi":"10.1016/j.oret.2025.12.011","DOIUrl":"10.1016/j.oret.2025.12.011","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":"10 9","pages":"Page e89"},"PeriodicalIF":5.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145934079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: Kiraly et al: Anatomical and functional outcomes after pars plana vitrectomy for giant retinal tear-related detachment: The Manchester GRT Study (Ophthalmol Retina. 2026;10:913-921)","authors":"Dhananjay Shukla MS, MAMS","doi":"10.1016/j.oret.2026.06.008","DOIUrl":"10.1016/j.oret.2026.06.008","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":"10 9","pages":"Pages e83-e84"},"PeriodicalIF":5.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148592821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resolution of Retained Perfluoro-n-Octane After Retinal Detachment Repair","authors":"Walton Spivey BS,&nbsp;Victor T. Copeland MD,&nbsp;Mohan N. Iyer MD","doi":"10.1016/j.oret.2025.12.007","DOIUrl":"10.1016/j.oret.2025.12.007","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":"10 9","pages":"Page e86"},"PeriodicalIF":5.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145912504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Macular Neovascularization in Neovascular Age-Related Macular Degeneration","authors":"Cristina Novarese MD,&nbsp;Chinmayi Vyas MD,&nbsp;Alessandro Berni MD,&nbsp;Daniela Bacherini MD,&nbsp;Varun Chaudhary MD,&nbsp;Rosa Dolz-Marco MD,&nbsp;Roberto Gallego-Pinazo MD,&nbsp;Rodolfo Mastropasqua MD, PhD,&nbsp;Gregor S. Reiter MD,&nbsp;Yousif Subhi MD,&nbsp;Francesco Bandello MD,&nbsp;Michele Reibaldi MD, PhD,&nbsp;Enrico Borrelli MD, PhD","doi":"10.1016/j.oret.2026.05.002","DOIUrl":"10.1016/j.oret.2026.05.002","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Topic&lt;/h3&gt;&lt;div&gt;This systematic review evaluates the methodologies used for assessing the macular neovascularization (MNV) in neovascular age-related macular degeneration (nAMD) using OCT angiography (OCTA). It focuses on identifying methodological heterogeneity in imaging and analysis protocols and its implications for clinical and research applications.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;This systematic review evaluates the methodologies used for assessing the macular neovascularization (MNV) in neovascular age-related macular degeneration (nAMD) using OCT angiography (OCTA). It focuses on identifying methodological heterogeneity in imaging and analysis protocols and its implications for clinical and research applications.&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Clinical Relevance&lt;/h3&gt;&lt;div&gt;Accurate assessment of MNV is critical for understanding disease activity, monitoring treatment response, and guiding clinical management in age-related macular degeneration (AMD). OCT angiography offers noninvasive, high-resolution visualization of neovascular networks, but variability in device types, scan protocols, segmentation strategies, and postprocessing methods hampers reproducibility and comparability across studies.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;Accurate assessment of MNV is critical for understanding disease activity, monitoring treatment response, and guiding clinical management in age-related macular degeneration (AMD). OCT angiography offers noninvasive, high-resolution visualization of neovascular networks, but variability in device types, scan protocols, segmentation strategies, and postprocessing methods hampers reproducibility and comparability across studies.&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;A systematic literature search was conducted in PubMed (Medline) and the Cochrane Library from inception through April 3, 2025. The review protocol was prospectively registered in the International Prospective Register of Systematic Reviews (CRD420251046977). Studies included patients with nAMD who underwent OCTA for MNV evaluation, irrespective of device type or scan parameters. Data extraction focused on OCTA technology, scan sizes, segmentation strategies, image processing techniques, quantitative metrics, and approaches to artifact reduction. A descriptive synthesis was performed.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;A systematic literature search was conducted in PubMed (Medline) and the Cochrane Library from inception through April 3, 2025. The review protocol was prospectively registered in the International Prospective Register of Systematic Reviews (CRD420251046977). Studies included patients with nAMD who underwent OCTA for MNV evaluation, irrespective of device type or scan parameters. Data extraction focused on OCTA technology, scan sizes, segmentation strategies, image processing techniques, quantitative metrics, and approaches to artifact reduction. A descriptive synthesis was performed.&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;A total of 155 studies, comprising 9025 patients (9669 eyes), were included. MNV subtypes incl","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":"10 9","pages":"Pages 951-965"},"PeriodicalIF":5.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147869137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"OCT-Defined Foveal Restoration Is Associated with Visual Recovery after Vitrectomy for Lamellar Macular Hole","authors":"Masaki Fukushima MD, PhD,&nbsp;Ryota Akai MD,&nbsp;Rikuto Inoue MD,&nbsp;Ryo Matoba MD, PhD,&nbsp;Takumi Ando MD, PhD,&nbsp;Hitoshi Goto MD, PhD,&nbsp;Ryoh Funatsu MD, MPH,&nbsp;Taku Wakabayashi MD, PhD,&nbsp;Tsuyoshi Kato MD, PhD,&nbsp;Kazuichi Maruyama MD, PhD,&nbsp;Atsushi Hayashi MD, FASRS,&nbsp;Shunji Kusaka MD, PhD,&nbsp;Takeshi Iwase MD, PhD,&nbsp;Yuki Morizane MD, PhD,&nbsp;Hiroko Terashima MD, PhD,&nbsp;Tadamichi Akagi MD, PhD,&nbsp;Kazunori Miyata MD, PhD,&nbsp;Yosai Mori MD, PhD,&nbsp;Noriko Kubota MD,&nbsp;Fumiki Okamoto MD, PhD,&nbsp;Kotaro Tsuboi MD, PhD","doi":"10.1016/j.oret.2026.05.015","DOIUrl":"10.1016/j.oret.2026.05.015","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Purpose&lt;/h3&gt;&lt;div&gt;Anatomic restoration after vitrectomy for lamellar macular hole (LMH) is not always achieved. However, the impact of unresolved LMH on visual outcomes remains unclear. We evaluated postoperative outcomes in eyes with unresolved LMH and postoperative full-thickness macular hole (FTMH) to reassess the meaning of anatomic success after LMH surgery.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;Anatomic restoration after vitrectomy for lamellar macular hole (LMH) is not always achieved. However, the impact of unresolved LMH on visual outcomes remains unclear. We evaluated postoperative outcomes in eyes with unresolved LMH and postoperative full-thickness macular hole (FTMH) to reassess the meaning of anatomic success after LMH surgery.&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Design&lt;/h3&gt;&lt;div&gt;Multicenter, retrospective cohort study.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;Multicenter, retrospective cohort study.&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Subjects&lt;/h3&gt;&lt;div&gt;One hundred sixty-six consecutive eyes of 166 patients who underwent vitrectomy for LMH.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;One hundred sixty-six consecutive eyes of 166 patients who underwent vitrectomy for LMH.&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;Anatomic success was defined as restoration of foveal configuration, whereby the postoperative OCT findings no longer met the diagnostic criteria for LMH. Postoperative anatomic outcomes were classified as anatomic success, unresolved LMH (including both persistent or recurrent LMH), or postoperative FTMH.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;Anatomic success was defined as restoration of foveal configuration, whereby the postoperative OCT findings no longer met the diagnostic criteria for LMH. Postoperative anatomic outcomes were classified as anatomic success, unresolved LMH (including both persistent or recurrent LMH), or postoperative FTMH.&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Main Outcome Measures&lt;/h3&gt;&lt;div&gt;Incidence and risk factors of unresolved LMH and postoperative FTMH, and best-corrected visual acuity (BCVA).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;Incidence and risk factors of unresolved LMH and postoperative FTMH, and best-corrected visual acuity (BCVA).&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Anatomic success was achieved in 141 eyes (84.9%), whereas 14 eyes (8.4%) had unresolved LMH and 11 eyes (6.6%) progressed to FTMH during follow-up (mean, 17.8 months). At 12 months, BCVA was significantly worse in eyes with unresolved LMH than in those with anatomic success (0.24 ± 0.24 vs. 0.09 ± 0.19 logarithm of the minimum angle of resolution [LogMAR]; &lt;em&gt;P&lt;/em&gt; = 0.041). Internal limiting membrane (ILM) peeling was significantly associated with a reduced risk of unresolved LMH (odds ratio [OR], 0.011; 95% confidence interval [CI], 0.002–0.062; &lt;em&gt;P&lt;/em&gt; &lt; 0.001). Postoperative FTMH was significantly associated with epiretinal proliferation (&lt;em&gt;P&lt;/em&gt; = 0.018), thinner preoperative central foveal thickness (&lt;em&gt;P&lt;/em&gt; = 0.017), and no ILM peeling (&lt;em&gt;P&lt;/em&gt; = 0.001). Multivariable analysis confirmed that ILM peeling was an independent factor preventing postoperative FTMH (OR, 0.080; 95% CI, 0.010–0.620; &lt;em&gt;","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":"10 9","pages":"Pages 932-943"},"PeriodicalIF":5.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148150670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anatomic and Functional Outcomes after Pars Plana Vitrectomy for Giant Retinal Tear–Related Retinal Detachment","authors":"Peter Kiraly MD, PhD,&nbsp;Tsveta Ivanova MD, PhD,&nbsp;Evita E. Christou MD,&nbsp;Fernando J. Huelin MD,&nbsp;Mariam Hussain MD,&nbsp;Felipe Dhawahir-Scala FRCS,&nbsp;Niall Patton MD, FRCOphth,&nbsp;Kirti M. Jasani FRCOphth,&nbsp;Assad Jalil FRCOphth,&nbsp;George Moussa FRCOphth","doi":"10.1016/j.oret.2026.04.028","DOIUrl":"10.1016/j.oret.2026.04.028","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Purpose&lt;/h3&gt;&lt;div&gt;To evaluate anatomic and functional outcomes after primary pars plana vitrectomy (PPV) for giant retinal tear–related rhegmatogenous retinal detachment (GRT-RRD) and to compare outcomes between gas and silicone oil (SO) tamponade.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;To evaluate anatomic and functional outcomes after primary pars plana vitrectomy (PPV) for giant retinal tear–related rhegmatogenous retinal detachment (GRT-RRD) and to compare outcomes between gas and silicone oil (SO) tamponade.&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Design&lt;/h3&gt;&lt;div&gt;Retrospective, single-center cohort study.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;Retrospective, single-center cohort study.&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Participants&lt;/h3&gt;&lt;div&gt;One hundred ten consecutive eyes undergoing primary PPV for GRT-RRD at a tertiary vitreoretinal service (2012–2024).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;One hundred ten consecutive eyes undergoing primary PPV for GRT-RRD at a tertiary vitreoretinal service (2012–2024).&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;Demographic, preoperative, and intraoperative variables were extracted from routinely collected clinical records. Baseline characteristics and outcomes were first compared between SO and gas groups using univariable analyses. To address confounding by indication, full propensity score matching was then performed. Single-surgery anatomic success (SSAS) was assessed with Firth logistic regression and final best-corrected visual acuity (BCVA) with weighted linear regression using G-computation.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;Demographic, preoperative, and intraoperative variables were extracted from routinely collected clinical records. Baseline characteristics and outcomes were first compared between SO and gas groups using univariable analyses. To address confounding by indication, full propensity score matching was then performed. Single-surgery anatomic success (SSAS) was assessed with Firth logistic regression and final best-corrected visual acuity (BCVA) with weighted linear regression using G-computation.&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Main Outcome Measures&lt;/h3&gt;&lt;div&gt;Single-surgery anatomic success, final anatomic success (FAS), and final BCVA (logarithm of the minimum angle of resolution [logMAR]).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;Single-surgery anatomic success, final anatomic success (FAS), and final BCVA (logarithm of the minimum angle of resolution [logMAR]).&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Mean age was 50.1 (16.0) years, and 83 of 110 (75.5%) patients were men. Macular detachment was present in 46 of 110 (41.8%) eyes. Gas tamponade was used in 76 of 110 (69.1%) eyes (SF6 5 of 110 [4.5%], C2F6 53 of 110 [48.2%], and C3F8 18 of 110 [16.4%]) and SO in 34 of 110 (30.9%) eyes. Single-surgery anatomic success was achieved in 97 of 110 (88.2%) eyes and FAS in 103 of 107 (96.3%). After propensity score matching, male sex was associated with higher odds of SSAS (odds ratio [OR], 4.54; 95% confidence interval [CI], 1.75–11.75; &lt;em&gt;P&lt;/em&gt; = 0.002), whereas proliferative vitreoretinopathy (PVR) grade C was associated with lower odds of SSAS (OR, 0.10; 95% CI, 0.02","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":"10 9","pages":"Pages 913-921"},"PeriodicalIF":5.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147869122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: Holz et al.: Adherence to intravitreal aflibercept in neovascular age-related macular degeneration: 24-month results from the ANDROMEDA Study (Ophthalmol. Retina. 2026;10:241-249)","authors":"Sangameshwar Manikya BDS,&nbsp;Varshini Vadhithala MBBS,&nbsp;Rajnish Kumar PhD,&nbsp;Pankaj Nainwal PhD","doi":"10.1016/j.oret.2026.06.013","DOIUrl":"10.1016/j.oret.2026.06.013","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":"10 9","pages":"Pages e81-e82"},"PeriodicalIF":5.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148861542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}