Ophthalmology. Retina最新文献

{"title":"Anterior Segment OCT in Bilateral Diffuse Uveal Melanocytic Proliferation.","authors":"Alessandro Feo, Edmund Tsui","doi":"10.1016/j.oret.2026.09.021","DOIUrl":"https://doi.org/10.1016/j.oret.2026.09.021","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149183432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sunburst Chorioretinal Folds in Macular Neovascularization.","authors":"Miri Meira Fogel Levin, Avner Hostovsky, Gabriel Katz","doi":"10.1016/j.oret.2026.09.022","DOIUrl":"https://doi.org/10.1016/j.oret.2026.09.022","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149183509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of Complex Retinal Detachment Repair with Proliferative Vitreoretinopathy Grade C using the Cincinnati Methotrexate Protocol.","authors":"Denis Huang, Jack E Feist, Sloane A McTavish, Muhammad Jehanzeb Khan, Robert A Sisk, Luke B Lindsell, James M Osher, Daniel M Miller, Robert K Hutchins, Haroon A Chaudhry, Marwan R Abdulaal, Chloe T L Khoo, Zujaja Tauqeer, Christopher D Riemann","doi":"10.1016/j.oret.2026.09.030","DOIUrl":"https://doi.org/10.1016/j.oret.2026.09.030","url":null,"abstract":"<p><strong>Purpose: </strong>To analyze the outcomes of an intravitreal methotrexate protocol in eyes that underwent complex retinal detachment (RD) repair for proliferative vitreoretinopathy (PVR).</p><p><strong>Design: </strong>Retrospective non-randomized comparative cohort study at a single tertiary ophthalmic center.</p><p><strong>Participants: </strong>Patients who underwent vitrectomy for RD with PVR grade C between 2019 and 2025.</p><p><strong>Methods: </strong>Three hundred eyes were included and divided into a treatment group of 150 eyes and a comparison cohort of 150 eyes. Patients in the treatment group received the Cincinnati Methotrexate (MTX) protocol, which delivers MTX as a 40 mg/500mL intraocular balanced salt solution infusion during vitrectomy and 200 to 400 μg intravitreal injections at post-operative weeks 1, 3, 6 and 10. Patients in the comparison cohort did not receive perioperative MTX. Multivariable regression analysis was performed to evaluate anatomic and visual outcomes. Minimum follow up interval was 6 months.</p><p><strong>Main outcome measures: </strong>The primary outcome measures were single surgery success rate (SSSR), postoperative PVR rate, postoperative visual acuity (VA) and final retinal attachment status. Secondary outcomes included adverse events related to MTX.</p><p><strong>Results: </strong>Eyes in the MTX group had higher odds of single surgery success (OR 5.15, 95% CI 2.77-10.15, p < 0.001) and lower odds of postoperative PVR (OR 0.15, 95% CI 0.08-0.26, p < 0.001), both of which remained significant with multivariable analysis. The MTX group had lower odds of final anatomic failure (OR 5.21, 95% CI 1.12-49.82, p = 0.03), which was not significant with multivariable analysis. Controlled for tamponade choice and lens status, the MTX group had superior VA at postoperative month 1 (p < 0.001), month 3 (p < 0.001), month 6 (p < 0.01), and month 12 (p = 0.02). There was no difference in serious ocular adverse events of special interest assessed between the two groups.</p><p><strong>Conclusion: </strong>A Cincinnati MTX regimen comprised of an intraoperative intraocular infusion and four intravitreal injections at postoperative weeks 1, 3, 6 and 10 was associated with higher single surgery success, lower postoperative PVR, and superior VA in complex RD repair with PVR grade C compared to a contemporaneous consecutive comparator cohort.</p>","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149183472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endogenous Klebsiella pneumoniae Endophthalmitis with a Large Subretinal Abscess.","authors":"Ruowen Gong, Qinmeng Shu, Ting Zhang","doi":"10.1016/j.oret.2026.09.013","DOIUrl":"https://doi.org/10.1016/j.oret.2026.09.013","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149183435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spontaneous Regression of Subretinal Fluid in Advanced Coats' Disease.","authors":"Waleed Khayyat, Sulaiman AlSulaiman","doi":"10.1016/j.oret.2026.09.015","DOIUrl":"https://doi.org/10.1016/j.oret.2026.09.015","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149170050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Statins and Age-Related Macular Degeneration: From a Class Effect to a Specific Hypothesis.","authors":"Xiaodong Chen, Ya Xing Wang","doi":"10.1016/j.oret.2026.09.008","DOIUrl":"https://doi.org/10.1016/j.oret.2026.09.008","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149137727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"REPLY.","authors":"Nimesh A Patel, Celine Chaaya, Yan Zhao, Srujay Pandiri","doi":"10.1016/j.oret.2026.09.006","DOIUrl":"https://doi.org/10.1016/j.oret.2026.09.006","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149137729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Solution in Search of Evidence: Yttrium-Aluminum-Garnet Vitreolysis for Vitreous Floaters.","authors":"Rahul N Khurana","doi":"10.1016/j.oret.2026.09.001","DOIUrl":"https://doi.org/10.1016/j.oret.2026.09.001","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149137605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reassessing Fellow-Eye Risk in Retinal Artery Occlusions.","authors":"Darius M Moshfeghi","doi":"10.1016/j.oret.2026.08.014","DOIUrl":"https://doi.org/10.1016/j.oret.2026.08.014","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149137682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vertical Hyperreflective Columns in Ocular Sarcoidosis.","authors":"Inês Mendo, Diogo Cabral, Cristina Fonseca","doi":"10.1016/j.oret.2026.09.012","DOIUrl":"https://doi.org/10.1016/j.oret.2026.09.012","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149137700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}