治疗初期全层黄斑孔视网膜上色素上皮颗粒沉积的多模态成像分析。

IF 5.7 Q1 OPHTHALMOLOGY

Ophthalmology. Retina Pub Date : 2025-08-01 DOI:10.1016/j.oret.2025.02.016

Daniela Bacherini MD, PhD , Stefano Mercuri MD , Andrea Govetto MD, PhD , Laura Di Leo MD , Tomaso Caporossi MD , Francesco Faraldi MD , Stanislao Rizzo MD , Gianni Virgili MD , Fabrizio Giansanti MD, PhD

{"title":"治疗初期全层黄斑孔视网膜上色素上皮颗粒沉积的多模态成像分析。","authors":"Daniela Bacherini MD, PhD , Stefano Mercuri MD , Andrea Govetto MD, PhD , Laura Di Leo MD , Tomaso Caporossi MD , Francesco Faraldi MD , Stanislao Rizzo MD , Gianni Virgili MD , Fabrizio Giansanti MD, PhD","doi":"10.1016/j.oret.2025.02.016","DOIUrl":null,"url":null,"abstract":"<div><h3>Purpose</h3><div>To describe the morphology and provide anatomical correlations of supra-retinal pigment epithelium (RPE) granular deposits in full-thickness macular holes (FTMHs).</div></div><div><h3>Design</h3><div>Retrospective, observational, single-center study.</div></div><div><h3>Participants</h3><div>Patients with idiopathic FTMH presenting to the University of Florence Eye clinic.</div></div><div><h3>Methods</h3><div>Thirty-six eyes of 34 patients with a diagnosis of treatment-naive FTMH, scheduled for surgery, underwent multimodal imaging including spectral-domain OCT (SD-OCT), en-face OCT, and adaptive optics ophthalmoscopy (AOO). Different methodologies were evaluated to determine the location and topographical correspondence of granulations. The total volume of supra-RPE granular deposits was correlated to the macular hole (MH) characteristics and SD-OCT markers of photoreceptor damage with Spearman correlation coefficient (CC).</div></div><div><h3>Main Outcome Measures</h3><div>Morphological correlations in FTMHs using SD-OCT and AOO.</div></div><div><h3>Results</h3><div>Using AOO, supra-RPE granular deposits appeared as hyper-reflective structures, mostly found within the minimum linear diameter (MLD) (104 of 139 deposits, 74%). Different imaging techniques were equally effective in the topographical identification of supra-RPE granular deposits (<em>P</em> > 0.30). The total volume of supra-RPE granular deposits significantly increased with stages B and C of FTMH, inversely correlated to the corrected ellipsoid zone (EZ) reflectivity (CC = −0.62) and positively correlated to the length of the EZ defect (CC = +0.41) and MH diameter at the base (CC = +0.35) and MLD (CC = +0.42) (all <em>P</em> < 0.05).</div></div><div><h3>Conclusions</h3><div>Supra-RPE granular deposits can be identified accurately using AOO and en-face OCT. Characteristics using AOO and anatomical correlations at SD-OCT indicate supra-RPE granular deposits as signs of photoreceptor degeneration.</div></div><div><h3>Financial Disclosure(s)</h3><div>The authors have no proprietary or commercial interest in any materials discussed in this article.</div></div>","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":"9 8","pages":"Pages 731-738"},"PeriodicalIF":5.7000,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Multimodal Imaging Analysis of Supra-retinal Pigment Epithelium Granular Deposits in Treatment-Naive Full-Thickness Macular Holes\",\"authors\":\"Daniela Bacherini MD, PhD , Stefano Mercuri MD , Andrea Govetto MD, PhD , Laura Di Leo MD , Tomaso Caporossi MD , Francesco Faraldi MD , Stanislao Rizzo MD , Gianni Virgili MD , Fabrizio Giansanti MD, PhD\",\"doi\":\"10.1016/j.oret.2025.02.016\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Purpose</h3><div>To describe the morphology and provide anatomical correlations of supra-retinal pigment epithelium (RPE) granular deposits in full-thickness macular holes (FTMHs).</div></div><div><h3>Design</h3><div>Retrospective, observational, single-center study.</div></div><div><h3>Participants</h3><div>Patients with idiopathic FTMH presenting to the University of Florence Eye clinic.</div></div><div><h3>Methods</h3><div>Thirty-six eyes of 34 patients with a diagnosis of treatment-naive FTMH, scheduled for surgery, underwent multimodal imaging including spectral-domain OCT (SD-OCT), en-face OCT, and adaptive optics ophthalmoscopy (AOO). Different methodologies were evaluated to determine the location and topographical correspondence of granulations. The total volume of supra-RPE granular deposits was correlated to the macular hole (MH) characteristics and SD-OCT markers of photoreceptor damage with Spearman correlation coefficient (CC).</div></div><div><h3>Main Outcome Measures</h3><div>Morphological correlations in FTMHs using SD-OCT and AOO.</div></div><div><h3>Results</h3><div>Using AOO, supra-RPE granular deposits appeared as hyper-reflective structures, mostly found within the minimum linear diameter (MLD) (104 of 139 deposits, 74%). Different imaging techniques were equally effective in the topographical identification of supra-RPE granular deposits (<em>P</em> > 0.30). The total volume of supra-RPE granular deposits significantly increased with stages B and C of FTMH, inversely correlated to the corrected ellipsoid zone (EZ) reflectivity (CC = −0.62) and positively correlated to the length of the EZ defect (CC = +0.41) and MH diameter at the base (CC = +0.35) and MLD (CC = +0.42) (all <em>P</em> < 0.05).</div></div><div><h3>Conclusions</h3><div>Supra-RPE granular deposits can be identified accurately using AOO and en-face OCT. Characteristics using AOO and anatomical correlations at SD-OCT indicate supra-RPE granular deposits as signs of photoreceptor degeneration.</div></div><div><h3>Financial Disclosure(s)</h3><div>The authors have no proprietary or commercial interest in any materials discussed in this article.</div></div>\",\"PeriodicalId\":19501,\"journal\":{\"name\":\"Ophthalmology. Retina\",\"volume\":\"9 8\",\"pages\":\"Pages 731-738\"},\"PeriodicalIF\":5.7000,\"publicationDate\":\"2025-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Ophthalmology. Retina\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2468653025000740\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"OPHTHALMOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ophthalmology. Retina","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2468653025000740","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

目的：描述全层黄斑孔（FTMHs）视网膜上色素上皮（RPE）颗粒沉积的形态学和解剖学相关性。设计：回顾性、观察性、单中心研究参与者：到佛罗伦萨大学眼科诊所就诊的特发性FTMH患者方法：34例诊断为治疗初期FTMH的患者36只眼，计划手术，接受多模态成像，包括光谱域光学相干断层扫描（SD-OCT）、正面OCT和自适应光学眼底镜检查（AOO）。评估了不同的方法来确定颗粒的位置和地形对应性。超rpe颗粒沉积物的总体积与MH特征和光感受器损伤的SD-OCT标志物具有Spearman相关系数（CC）。结果：利用AOO法，超rpe颗粒状沉积物呈现超反射结构，主要分布在最小线径（MLD）范围内（104/139,74%）。不同的成像技术在超rpe颗粒矿床的地形识别中同样有效（p>0.30）。超rpe颗粒沉积物的总体积随着FTMH的B、C阶段显著增加，与校正椭球区（EZ）反射率（CC=-0.62）呈负相关，与EZ缺陷长度（CC=+0.41）、底部MH直径（CC=+0.35）、MLD （CC=+0.42）呈正相关（均p < 0.05）。超rpe颗粒沉积可以通过AOO和正面oct准确识别。在SD-OCT上，AOO和解剖相关性表明超rpe颗粒沉积是光感受器变性的标志。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Multimodal Imaging Analysis of Supra-retinal Pigment Epithelium Granular Deposits in Treatment-Naive Full-Thickness Macular Holes

Purpose

To describe the morphology and provide anatomical correlations of supra-retinal pigment epithelium (RPE) granular deposits in full-thickness macular holes (FTMHs).

Design

Retrospective, observational, single-center study.

Participants

Patients with idiopathic FTMH presenting to the University of Florence Eye clinic.

Methods

Thirty-six eyes of 34 patients with a diagnosis of treatment-naive FTMH, scheduled for surgery, underwent multimodal imaging including spectral-domain OCT (SD-OCT), en-face OCT, and adaptive optics ophthalmoscopy (AOO). Different methodologies were evaluated to determine the location and topographical correspondence of granulations. The total volume of supra-RPE granular deposits was correlated to the macular hole (MH) characteristics and SD-OCT markers of photoreceptor damage with Spearman correlation coefficient (CC).

Main Outcome Measures

Morphological correlations in FTMHs using SD-OCT and AOO.

Results

Using AOO, supra-RPE granular deposits appeared as hyper-reflective structures, mostly found within the minimum linear diameter (MLD) (104 of 139 deposits, 74%). Different imaging techniques were equally effective in the topographical identification of supra-RPE granular deposits (P > 0.30). The total volume of supra-RPE granular deposits significantly increased with stages B and C of FTMH, inversely correlated to the corrected ellipsoid zone (EZ) reflectivity (CC = −0.62) and positively correlated to the length of the EZ defect (CC = +0.41) and MH diameter at the base (CC = +0.35) and MLD (CC = +0.42) (all P < 0.05).

Conclusions

Supra-RPE granular deposits can be identified accurately using AOO and en-face OCT. Characteristics using AOO and anatomical correlations at SD-OCT indicate supra-RPE granular deposits as signs of photoreceptor degeneration.