Ophthalmology. Retina最新文献

{"title":"Novel CNNM4 Variant Causing Jalili Syndrome in Identical Twin Sisters","authors":"Utsav Shah DNB, Srikanta Kumar Padhy MD","doi":"10.1016/j.oret.2025.12.015","DOIUrl":"10.1016/j.oret.2025.12.015","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":"10 9","pages":"Page e91"},"PeriodicalIF":5.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145934157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bipedicle Internal Limiting Membrane Flap for Recalcitrant Macular Holes with Previously Removed Internal Limiting Membrane","authors":"Homayoun Tabandeh MD","doi":"10.1016/j.oret.2026.05.007","DOIUrl":"10.1016/j.oret.2026.05.007","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":"10 9","pages":"Pages 975-977"},"PeriodicalIF":5.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147982690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Time from Diagnosis to Treatment and Baseline Vision on Retinal Vein Occlusion Outcomes in Aflibercept 2 mg Phase III Trials","authors":"Sumit Sharma MD, Dilsher S. Dhoot MD, Dilraj S. Grewal MD, Eric Jung MD, Fabiana Q. Silva MD, Weiming Du MS, Hadi Moini PhD, David S. Boyer MD","doi":"10.1016/j.oret.2026.04.027","DOIUrl":"10.1016/j.oret.2026.04.027","url":null,"abstract":"<div><h3>Objective</h3><div>To examine the impacts of time since diagnosis of macular edema after central or branch retinal vein occlusion (MEfCRVO or MEfBRVO) to the first intravitreal aflibercept 2 mg injection (IAI) and baseline best-corrected visual acuity (BCVA) on visual and anatomic outcomes and to inform treatment decisions and management of physician and patient expectations.</div></div><div>To examine the impacts of time since diagnosis of macular edema after central or branch retinal vein occlusion (MEfCRVO or MEfBRVO) to the first intravitreal aflibercept 2 mg injection (IAI) and baseline best-corrected visual acuity (BCVA) on visual and anatomic outcomes and to inform treatment decisions and management of physician and patient expectations.</div><div><h3>Design</h3><div>Post hoc analysis of 3 clinical trials.</div></div><div>Post hoc analysis of 3 clinical trials.</div><div><h3>Participants</h3><div>Patients with MEfCRVO from COPERNICUS and GALILEO treated with IAI every 4 weeks, followed by as needed from week 24 to 100 (COPERNICUS) or 76 (GALILEO), and patients with MEfBRVO from VIBRANT treated with IAI every 4 weeks, followed by every 8 weeks from week 24 to 52.</div></div><div>Patients with MEfCRVO from COPERNICUS and GALILEO treated with IAI every 4 weeks, followed by as needed from week 24 to 100 (COPERNICUS) or 76 (GALILEO), and patients with MEfBRVO from VIBRANT treated with IAI every 4 weeks, followed by every 8 weeks from week 24 to 52.</div><div><h3>Methods</h3><div>Patients were grouped by time from initial MEfCRVO/MEfBRVO diagnosis to first IAI, <1, 1 to 3, or >3 months (COPERNICUS/GALILEO), and <1 or ≥1 month (VIBRANT).</div></div><div>Patients were grouped by time from initial MEfCRVO/MEfBRVO diagnosis to first IAI, <1, 1 to 3, or >3 months (COPERNICUS/GALILEO), and <1 or ≥1 month (VIBRANT).</div><div><h3>Main Outcome Measures</h3><div>Impact of baseline BCVA was evaluated by tertiles: T1, ≤44; T2, >44 to ≤58; T3, >58 letters (COPERNICUS); T1, ≤47; T2, >47 to ≤65; T3, >65 letters (GALILEO); and T1, ≤55; T2, >55 to ≤64; and T3, >64 letters (VIBRANT).</div></div><div>Impact of baseline BCVA was evaluated by tertiles: T1, ≤44; T2, >44 to ≤58; T3, >58 letters (COPERNICUS); T1, ≤47; T2, >47 to ≤65; T3, >65 letters (GALILEO); and T1, ≤55; T2, >55 to ≤64; and T3, >64 letters (VIBRANT).</div><div><h3>Results</h3><div>In COPERNICUS, 113 patients initiated IAI at <1 (n = 44; 38.9%), 1 to 3 (n = 33; 29.2%), or >3 months (n = 36; 31.9%) post-diagnosis; mean BCVA gains from baseline at week 24 were 19.8, 15.6, and 11.9 letters, respectively (mean [95% confidence interval] difference between <1- and >3-month groups: +7.9 [1.7–14.1]; <em>P</em> = 0.01). Central subfield thickness (CST) decrease from baseline at week 24 across time-since-diagnosis subgroups was –466.6, –456.4, and –479.2 μm, respectively. Least squares mean BCVA gains from baseline at week 100 were grea","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":"10 9","pages":"Pages 966-974"},"PeriodicalIF":5.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147841050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progressive Foveal Involvement in Congenital Hypertrophy of the Retinal Pigment Epithelium","authors":"Pedro Carreira MD, Prithvi Ramtohul MD, Diogo Cabral MD","doi":"10.1016/j.oret.2025.12.012","DOIUrl":"10.1016/j.oret.2025.12.012","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":"10 9","pages":"Page e90"},"PeriodicalIF":5.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145934098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Familial Chylomicronemia Syndrome—Lipemia Retinalis","authors":"Zu Jie MM, Ma Qingmin MM","doi":"10.1016/j.oret.2025.12.022","DOIUrl":"10.1016/j.oret.2025.12.022","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":"10 9","pages":"Page e92"},"PeriodicalIF":5.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146041486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Highly Myopic Macular Hole Surgery by the Internal Limiting Membrane Flap with No Gas Tamponade Technique","authors":"Simon K.H. Szeto FRCOphth, Amy H.Y. Yu FCOphth(HK), Vivian W.K. Hui FCOphth(HK), Julia T.W. Lam MBChB, Ken K. Tsang FRCOphth, Timothy P.H. Lin MBChB, Christopher M.K. Pang MBChB, Ziqi Tang PhD, Timothy Y.Y. Lai MD, Shaheeda Mohamed FCOphth(HK), Chi Wai Tsang FCOphth(HK)","doi":"10.1016/j.oret.2026.04.023","DOIUrl":"10.1016/j.oret.2026.04.023","url":null,"abstract":"<div><h3>Purpose</h3><div>To report the surgical outcomes of the internal limiting membrane (ILM) flap with no gas tamponade technique in managing high myopia–associated macular hole (MH).</div></div><div>To report the surgical outcomes of the internal limiting membrane (ILM) flap with no gas tamponade technique in managing high myopia–associated macular hole (MH).</div><div><h3>Design</h3><div>Prospective interventional case series.</div></div><div>Prospective interventional case series.</div><div><h3>Participants</h3><div>Patients with high myopia–associated full-thickness MH.</div></div><div>Patients with high myopia–associated full-thickness MH.</div><div><h3>Methods</h3><div>Consecutive patients with high myopia–associated MH were prospectively recruited. High myopia was defined as refraction of spherical equivalence of ≤–6.0 diopters (in phakic eyes) or axial length (AL) ≥26 mm. The ILM flap without gas tamponade technique was used for MH repair; conversion to conventional surgery with gas tamponade was the contingency surgical plan when necessary.</div></div><div>Consecutive patients with high myopia–associated MH were prospectively recruited. High myopia was defined as refraction of spherical equivalence of ≤–6.0 diopters (in phakic eyes) or axial length (AL) ≥26 mm. The ILM flap without gas tamponade technique was used for MH repair; conversion to conventional surgery with gas tamponade was the contingency surgical plan when necessary.</div><div><h3>Main Outcomes Measures</h3><div>Primary outcome was the MH closure rate at week 12. Key secondary outcomes included postoperative best-corrected visual acuity (BCVA) and time to MH closure.</div></div><div>Primary outcome was the MH closure rate at week 12. Key secondary outcomes included postoperative best-corrected visual acuity (BCVA) and time to MH closure.</div><div><h3>Results</h3><div>Twenty eyes from 20 patients were included. The mean age was 67.2 years, and the median duration of symptoms was 9.5 months. The mean ± standard deviation baseline logarithm of the minimum angle of resolution BCVA was 0.77 ± 0.39, the mean AL was 28.9 ± 2.20 mm, and the mean minimum linear diameter was 424.0 ± 197.7 μm. All participants underwent the planned study intervention and completed the week 12 visit for the assessment of the primary outcome. Macular hole closure was achieved in 20 (100%) eyes at week 12, and the median time to MH closure was 1 week (range, 0–12 weeks). The postoperative mean logarithm of the minimum angle of resolution BCVA was 0.75 ± 0.29 (<em>P</em> = 0.832), 0.50 ± 0.25 (<em>P</em> = 0.013), 0.36 ± 0.21 (<em>P</em> < 0.001), 0.30 ± 0.21 (<em>P</em> < 0.001), and 0.25 ± 0.23 (<em>P</em> < 0.001) at postoperative day 1 and weeks 1, 4, 12, and 24, respectively. The number of eyes with BCVA ≥20/50 increased from 6 (30%) on day 1 to 12 (60%), 17 (85%), 18 (90%), and 18 (94.7%) at weeks 1, 4, 12, and 24, respectively.</div></div><div>Twenty eyes from 20 patients were includ","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":"10 9","pages":"Pages 922-931"},"PeriodicalIF":5.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Atopic Dermatitis with Retinal Detachment and Postoperative Proliferative Vitreoretinopathy Risk","authors":"Alexander T. Hong BS, Forest Lin BS, Ehsan Rahimy MD, Pradeep S. Prasad MD","doi":"10.1016/j.oret.2026.05.006","DOIUrl":"10.1016/j.oret.2026.05.006","url":null,"abstract":"<div><h3>Purpose</h3><div>To evaluate the association between atopic dermatitis (AD) and risk of retinal detachment (RD), postoperative proliferative vitreoretinopathy (PVR), and complex RD repair after initial RD repair.</div></div><div>To evaluate the association between atopic dermatitis (AD) and risk of retinal detachment (RD), postoperative proliferative vitreoretinopathy (PVR), and complex RD repair after initial RD repair.</div><div><h3>Design</h3><div>Retrospective, population-based cohort study.</div></div><div>Retrospective, population-based cohort study.</div><div><h3>Participants</h3><div>Adults aged ≥18 years with and without a diagnosis of AD identified from March 2006 to March 2026.</div></div><div>Adults aged ≥18 years with and without a diagnosis of AD identified from March 2006 to March 2026.</div><div><h3>Methods</h3><div>This retrospective cohort study used data from a federated health research network containing aggregated, deidentified electronic health records from 72 US health care organizations. Patients with AD, identified by International Classification of Diseases, 10th revision codes, were matched 1:1 to controls without documented AD using propensity scores, balancing for demographic characteristics, ocular comorbidities, tobacco use, and systemic corticosteroid exposure. Two analyses were performed: (1) risk of RD diagnosis and RD repair after initial AD diagnosis or outpatient clinic visit; and (2) risk of postoperative PVR and complex RD repair after initial RD repair.</div></div><div>This retrospective cohort study used data from a federated health research network containing aggregated, deidentified electronic health records from 72 US health care organizations. Patients with AD, identified by International Classification of Diseases, 10th revision codes, were matched 1:1 to controls without documented AD using propensity scores, balancing for demographic characteristics, ocular comorbidities, tobacco use, and systemic corticosteroid exposure. Two analyses were performed: (1) risk of RD diagnosis and RD repair after initial AD diagnosis or outpatient clinic visit; and (2) risk of postoperative PVR and complex RD repair after initial RD repair.</div><div><h3>Main Outcome Measures</h3><div>Outcomes for the first analysis included rates of RD repair and RD diagnosis at 1 and 5 years after the index event. Outcomes in the second analysis included rates of PVR (International Classification of Diseases, 10th revision: H35.2) and complex RD repair (Current Procedural Terminology: 67113) within a 180-day period of initial RD repair.</div></div><div>Outcomes for the first analysis included rates of RD repair and RD diagnosis at 1 and 5 years after the index event. Outcomes in the second analysis included rates of PVR (International Classification of Diseases, 10th revision: H35.2) and complex RD repair (Current Procedural Terminology: 67113) within a 180-day period of initial RD repair.</div><div><h3>Results</h3><div>A t","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":"10 9","pages":"Pages 944-950"},"PeriodicalIF":5.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147974408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Black Boxes to Biomarkers: Artificial Intelligence in Surgical Retina","authors":"Lucie Y. Guo MD, PhD, Daniel S.W. Ting MD, PhD","doi":"10.1016/j.oret.2026.06.003","DOIUrl":"10.1016/j.oret.2026.06.003","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":"10 9","pages":"Pages 897-899"},"PeriodicalIF":5.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148664280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When the Retina Crystallizes: Retinal Oxalosis with Neovascular Sequelae","authors":"Shweta Jagdeesh MS, Anuradha Vadakke Kanakath MD, Palmeera D. Souza DO, DNB","doi":"10.1016/j.oret.2026.01.001","DOIUrl":"10.1016/j.oret.2026.01.001","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":"10 9","pages":"Page e93"},"PeriodicalIF":5.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146030427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitreoretinal Abnormalities in Poretti–Boltshauser Syndrome: An Imaging Overview","authors":"Samet Gulkas MD, Ines Fenniri MD, Anne Fulton MD","doi":"10.1016/j.oret.2025.12.010","DOIUrl":"10.1016/j.oret.2025.12.010","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":"10 9","pages":"Page e88"},"PeriodicalIF":5.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145912544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}