Ophthalmology. Retina最新文献

筛选
英文 中文
Aggressive-Retinopathy of Prematurity or Oxygen-Induced Retinopathy? 侵袭性:早产儿视网膜病变还是氧致视网膜病变?
IF 5.9
Ophthalmology. Retina Pub Date : 2026-09-01 Epub Date: 2026-01-07 DOI: 10.1016/j.oret.2025.12.009
Abhishek Singh DO, DNB, Deepshikha Agrawal MS, Anil Babanrao Gangwe MD
{"title":"Aggressive-Retinopathy of Prematurity or Oxygen-Induced Retinopathy?","authors":"Abhishek Singh DO, DNB, Deepshikha Agrawal MS, Anil Babanrao Gangwe MD","doi":"10.1016/j.oret.2025.12.009","DOIUrl":"10.1016/j.oret.2025.12.009","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":"10 9","pages":"Page e87"},"PeriodicalIF":5.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145912552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Artificial Intelligence-Based Prognostic Models for Postoperative Outcomes in Vitreoretinal Surgery 基于人工智能的玻璃体视网膜手术术后预后模型:系统回顾和荟萃分析。
IF 5.9
Ophthalmology. Retina Pub Date : 2026-09-01 Epub Date: 2026-05-04 DOI: 10.1016/j.oret.2026.04.022
Abdullah Al-Ani MD, PhD, Liam Connors MD, MSc, David Mikhail MD(c), MSc, Mayar Alkhawaja MD(c), BHSc, Lucy Yang MD, Athithan Ambikkumar MD, Karim Punja MD, Fiona Costello MD, Patrick Gooi MD, Monique Munro MD
{"title":"Artificial Intelligence-Based Prognostic Models for Postoperative Outcomes in Vitreoretinal Surgery","authors":"Abdullah Al-Ani MD, PhD, Liam Connors MD, MSc, David Mikhail MD(c), MSc, Mayar Alkhawaja MD(c), BHSc, Lucy Yang MD, Athithan Ambikkumar MD, Karim Punja MD, Fiona Costello MD, Patrick Gooi MD, Monique Munro MD","doi":"10.1016/j.oret.2026.04.022","DOIUrl":"10.1016/j.oret.2026.04.022","url":null,"abstract":"<div><h3>Topic</h3><div>This review evaluated the performance of artificial intelligence (AI) models for predicting outcomes after vitreoretinal surgery compared with conventional statistical approaches.</div></div><div>This review evaluated the performance of artificial intelligence (AI) models for predicting outcomes after vitreoretinal surgery compared with conventional statistical approaches.</div><div><h3>Clinical Relevance</h3><div>The ability of AI to analyze high-volume and diverse data may augment preoperative prognostication to better facilitate counseling and surgical planning.</div></div><div>The ability of AI to analyze high-volume and diverse data may augment preoperative prognostication to better facilitate counseling and surgical planning.</div><div><h3>Methods</h3><div>After registration (NPLASY202380012; <span><span>https://doi.org/10.37766/inplasy2023.8.0012</span><svg><path></path></svg></span>), a search was conducted in MEDLINE, Embase, Cochrane databases, Compendex, IEEE, Web of Science, and Scopus, supplemented by gray literature—primary studies using AI to predict vitreoretinal surgical outcomes were included. Studies involving laser procedures, intraocular lens calculations, or nonpredictive models were excluded. Risk of bias was evaluated using the Prediction Model Risk of Bias Assessment Tool (PROBAST), and the overall quality of evidence was assessed using the Grading of Recommendations, Assessment, Development, and Evaluation framework.</div></div><div>After registration (NPLASY202380012; <span><span>https://doi.org/10.37766/inplasy2023.8.0012</span><svg><path></path></svg></span>), a search was conducted in MEDLINE, Embase, Cochrane databases, Compendex, IEEE, Web of Science, and Scopus, supplemented by gray literature—primary studies using AI to predict vitreoretinal surgical outcomes were included. Studies involving laser procedures, intraocular lens calculations, or nonpredictive models were excluded. Risk of bias was evaluated using the Prediction Model Risk of Bias Assessment Tool (PROBAST), and the overall quality of evidence was assessed using the Grading of Recommendations, Assessment, Development, and Evaluation framework.</div><div><h3>Results</h3><div>Of 827 abstracts screened, 26 studies (18724 eyes) met eligibility criteria; 12 studies were eligible for meta-analysis. Men accounted for 52% (n = 9807) of included patients. The most common surgical indication was macular hole (n = 10, 40%). Convolutional neural networks were the most investigated deep learning algorithms (n = 7, 30%), with best-corrected visual acuity being the highest frequency outcome (n = 12, 46%). Most studies (n = 8, 69%) reported deep learning or machine learning outperformance to conventional statistical approaches. Across pooled outcomes, ground truth was defined as clinician-ascertained presence of postoperative outcome during follow-up in each study. A meta-analysis of 12 studies (n = 4536 participants) revealed a pooled sensiti","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":"10 9","pages":"Pages 900-912"},"PeriodicalIF":5.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147841135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Proliferative Diabetic Retinopathy Incidence and Outcomes in Younger Patients from 1970 to 2019 1970-2019年年轻患者增殖性糖尿病视网膜病变的发病率和结局
IF 5.9
Ophthalmology. Retina Pub Date : 2026-09-01 Epub Date: 2026-05-19 DOI: 10.1016/j.oret.2026.05.010
Jenna R. Krivit MD, Kenny Y. Wang MD, Jorge S. Andrade Romo MD, Aravindh Nirmalan MD, Patricia Bai MD, Brian G. Mohney MD, Paul A. Decker MS, David O. Hodge MS, Sophie J. Bakri MD, Raymond Iezzi MD, MS, Andrew J. Barkmeier MD
{"title":"Proliferative Diabetic Retinopathy Incidence and Outcomes in Younger Patients from 1970 to 2019","authors":"Jenna R. Krivit MD, Kenny Y. Wang MD, Jorge S. Andrade Romo MD, Aravindh Nirmalan MD, Patricia Bai MD, Brian G. Mohney MD, Paul A. Decker MS, David O. Hodge MS, Sophie J. Bakri MD, Raymond Iezzi MD, MS, Andrew J. Barkmeier MD","doi":"10.1016/j.oret.2026.05.010","DOIUrl":"10.1016/j.oret.2026.05.010","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":"10 9","pages":"Pages 977-979"},"PeriodicalIF":5.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147982750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SSGJ-601 versus Ranibizumab for Macular Edema Secondary to Branch Retinal Vein Occlusion: 52-Week Results from a Phase 3 Study. SSGJ-601与雷尼单抗治疗视网膜分支静脉闭塞继发黄斑水肿:52周的3期研究结果
IF 5.9
Ophthalmology. Retina Pub Date : 2026-08-31 DOI: 10.1016/j.oret.2026.08.025
Linni Wang, Zhiqing Li, Xinjun Ren, Liangzhang Tan, Shuo Zhao, Yingyi Lu, Jilong Hao, Miaoqin Wu, Xinyan Xu, Huijun Shi, Qian Ren, Zhipeng You, Yanping Song, Wenfang Zhang, Chunling Lei, Ximei Zhang, Xian Wang, Wei Tan, Songtao Yuan, Liming Tao, Changzheng Chen, Zongming Song, Wenjuan Zhuang, Hong Zhang, Quanhong Han, Yu Jin, Jianjun Peng, Qing Zhang, Jianlu Gao, Xuemei Pan, Ye Shen, Mingxin Li, Jianfeng Wang, Liangbao An, Xiaoling Liu, Jun Li, Lixun Chen, Hong Wang, Jinglin Zhang, Zixia Zhou, Jingxiang Zhong, Yanling Wang, Tonghe Zhang, Wei Xiong, Ling Cui, Xiaoyan Peng, Mochi Yang, Ming Zhang, Zhuo Li, Hailin Wang, Jing Lou, Yanli Liu, Hong Dai, Xiaorong Li
{"title":"SSGJ-601 versus Ranibizumab for Macular Edema Secondary to Branch Retinal Vein Occlusion: 52-Week Results from a Phase 3 Study.","authors":"Linni Wang, Zhiqing Li, Xinjun Ren, Liangzhang Tan, Shuo Zhao, Yingyi Lu, Jilong Hao, Miaoqin Wu, Xinyan Xu, Huijun Shi, Qian Ren, Zhipeng You, Yanping Song, Wenfang Zhang, Chunling Lei, Ximei Zhang, Xian Wang, Wei Tan, Songtao Yuan, Liming Tao, Changzheng Chen, Zongming Song, Wenjuan Zhuang, Hong Zhang, Quanhong Han, Yu Jin, Jianjun Peng, Qing Zhang, Jianlu Gao, Xuemei Pan, Ye Shen, Mingxin Li, Jianfeng Wang, Liangbao An, Xiaoling Liu, Jun Li, Lixun Chen, Hong Wang, Jinglin Zhang, Zixia Zhou, Jingxiang Zhong, Yanling Wang, Tonghe Zhang, Wei Xiong, Ling Cui, Xiaoyan Peng, Mochi Yang, Ming Zhang, Zhuo Li, Hailin Wang, Jing Lou, Yanli Liu, Hong Dai, Xiaorong Li","doi":"10.1016/j.oret.2026.08.025","DOIUrl":"https://doi.org/10.1016/j.oret.2026.08.025","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the clinical efficacy, safety, and immunogenicity of biosimilar SSGJ-601 compared with ranibizumab in patients with macular edema secondary to branch retinal vein occlusion (BRVO).</p><p><strong>Design: </strong>A multicenter, randomized, double-masked, active-controlled phase 3 clinical study.</p><p><strong>Participants: </strong>A total of 351 patients with macular edema secondary to BRVO were enrolled.</p><p><strong>Methods: </strong>Evaluable patients (N=351) were randomized to receive intravitreal SSGJ-601(1.25mg per eye, Q4W) or intravitreal ranibizumab (0.5mg per eye, Q4W) from day 1 through week 20 (6 injections in total), and treatment transitioned to a pro re nata (PRN) schedule based on investigator-assessed retreatment criteria from week 24 to week 48. All patients completed their end-of-study visit at week 52.</p><p><strong>Main outcome measures: </strong>The primary efficacy endpoint was the Least Squares (LS) mean difference in change in best-corrected visual acuity (BCVA), measured by Early Treatment Diabetic Retinopathy Study (ETDRS) letter score, from baseline to week 24. Secondary efficacy endpoints, safety, pharmacokinetics, immunogenicity and change in VEGF concentration of SSGJ-601 were also analyzed.</p><p><strong>Results: </strong>Demographic and baseline characteristics and exposure to treatment were similar between groups. In the study eye, SSGJ-601 was non-inferior to ranibizumab in improving the LS mean in BCVA letter count from baseline to week 24 (17.6 (0.66) vs. 18.2 (0.65) letters, -0.6 with 95%CI: (-2.4,1.3), P for non-inferior<0.0001), thus, the primary clinical efficacy end point was met. At each time point, the proportions of patients achieving BCVA gains of ≥5, ≥10, and ≥15 letters in the SSGJ-601 group were non-inferior to those in the ranibizumab group. Drug-related TEAEs (11.4% vs. 12.5%) and SAEs (6.9% vs. 9.1%) were comparable in the two treatment groups. A low incidence of binding antidrug antibodies was observed in SSGJ-611 group.</p><p><strong>Conclusions: </strong>This study supports the conclusion of no clinical meaningful differences in efficacy, safety, and immunogenicity between SSGJ-601 and ranibizumab in patients with macular edema secondary to BRVO. Additionally, treatment transitioned to a pro re nata (PRN) schedule based on investigator-assessed retreatment criteria resulted in sustained benefits in visual and anatomical outcomes.</p>","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148865077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retinal Detachment Reporting Following Topical Pilocarpine 1.25% for Presbyopia. 局部使用1.25%的匹罗卡品治疗老花眼后报告视网膜脱离。
IF 5.9
Ophthalmology. Retina Pub Date : 2026-08-26 DOI: 10.1016/j.oret.2026.08.027
Kishan Avaiya, Hashem Abu Serhan
{"title":"Retinal Detachment Reporting Following Topical Pilocarpine 1.25% for Presbyopia.","authors":"Kishan Avaiya, Hashem Abu Serhan","doi":"10.1016/j.oret.2026.08.027","DOIUrl":"https://doi.org/10.1016/j.oret.2026.08.027","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148830883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evidence and Consensus Based Guidelines in Behçet Disease Uveitis. Multimodal imaging in Uveitis (MUV) Taskforce Report 18. 基于证据和共识的behet病葡萄膜炎指南。葡萄膜炎(MUV)的多模态成像
IF 5.9
Ophthalmology. Retina Pub Date : 2026-08-25 DOI: 10.1016/j.oret.2026.08.019
Reema Bansal, Ilknur Tugal-Tutkun, Sofia Androudi, Peter McCluskey, Hiroshi Keino, Lucia Sobrin, Oren Tomkins-Netzer, Sapna Gangaputra, Aniruddha Agarwal, Francesco Pichi, Rupesh Agrawal, Alessandro Invernizzi, Douglas A Jabs, Janet L Davis, Jennifer E Thorne, Carlos Pavesio, Massimo Accorinti, Justine R Smith, David Sarraf, Vishali Gupta
{"title":"Evidence and Consensus Based Guidelines in Behçet Disease Uveitis. Multimodal imaging in Uveitis (MUV) Taskforce Report 18.","authors":"Reema Bansal, Ilknur Tugal-Tutkun, Sofia Androudi, Peter McCluskey, Hiroshi Keino, Lucia Sobrin, Oren Tomkins-Netzer, Sapna Gangaputra, Aniruddha Agarwal, Francesco Pichi, Rupesh Agrawal, Alessandro Invernizzi, Douglas A Jabs, Janet L Davis, Jennifer E Thorne, Carlos Pavesio, Massimo Accorinti, Justine R Smith, David Sarraf, Vishali Gupta","doi":"10.1016/j.oret.2026.08.019","DOIUrl":"https://doi.org/10.1016/j.oret.2026.08.019","url":null,"abstract":"<p><strong>Purpose: </strong>To develop imaging and consensus-based guidelines for the application of multimodal imaging in the clinical diagnosis, monitoring and detection of complications in Behçet disease (BD) uveitis.</p><p><strong>Design: </strong>International expert consensus agreement using the nominal group technique (NGT) guided by systematic literature review.</p><p><strong>Participants: </strong>International uveitis and retina experts participating in the Multimodal Imaging in Uveitis (MUV) taskforce.</p><p><strong>Methods: </strong>A committee of experts reviewed the published literature on imaging in BD uveitis, along with representative multimodal imaging datasets of active, resolved and late-stage uveitis in BD. All cases in these datasets met the Standardized Uveitis Nomenclature (SUN) diagnostic criteria. Imaging modalities included color fundus photography (CFP), fundus fluorescein angiography (FFA), optical coherence tomography (OCT), fundus autofluorescence (FAF), indocyanine green angiography (ICGA), and OCT angiography (OCTA). NGT sessions were conducted to define consensus-based key imaging descriptors of active and resolved BD uveitis, along with the complications and sequelae.</p><p><strong>Main outcome measures: </strong>Identification of reproducible multimodal imaging features of active and resolved BD uveitis.</p><p><strong>Results: </strong>The experts agreed that CFP, FFA and OCT are the most relevant imaging modalities in the management of BD uveitis, with particular emphasis on ultra-widefield imaging. Characteristic findings on CFP include vitreous haze, retinal infiltrates, optic nerve head inflammation, and prominent retinal vasculitis with possible occlusion. FFA was deemed critical in assessing vascular, macular and optic nerve head leakage, thereby indicating disease activity. OCT is helpful in detecting and characterizing cystoid macular edema, partial thickness inner retinitis (smudge-sign), subretinal fluid, and overlying vitreous condensation. FFA and OCT assist in demonstrating disease resolution, and detection of late changes such as retinal non-perfusion, neovascularization, epiretinal membrane formation and retinal atrophy. The experts concluded that FAF, ICGA and OCTA have limited role in disease. Based on these findings, consensus-based statements were generated and voted upon by the MUV taskforce.</p><p><strong>Conclusion: </strong>Incorporation of consensus-based imaging guidelines by MUV, particularly CFP, FFA and OCT, enhances diagnostic evaluation, improves assessment of disease activity, assessment of treatment response, and detection of complications in BD uveitis. These recommendations provide a structured framework for optimal multimodal imaging use in BD uveitis and aid future refinements of diagnostic criteria.</p>","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148819245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Late Recurrent Coats' Disease: Clinical Characteristics and Treatment Outcome. 晚期复发性Coats病:临床特征和治疗结果。
IF 5.9
Ophthalmology. Retina Pub Date : 2026-08-24 DOI: 10.1016/j.oret.2026.08.018
Lu Ruan, Xiao Li, Meng Zhang, Yanjun Wen, Qian Yang, Juan Zhang, Xin Huang
{"title":"Late Recurrent Coats' Disease: Clinical Characteristics and Treatment Outcome.","authors":"Lu Ruan, Xiao Li, Meng Zhang, Yanjun Wen, Qian Yang, Juan Zhang, Xin Huang","doi":"10.1016/j.oret.2026.08.018","DOIUrl":"https://doi.org/10.1016/j.oret.2026.08.018","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the clinical characteristics and outcomes of late recurrent Coats' disease after complete resolution.</p><p><strong>Design: </strong>Retrospective, comparative case-control study.</p><p><strong>Participants: </strong>A total of 155 patients (155 eyes) with unilateral Coats' disease who achieved complete resolution after treatment and were followed for > 12 months thereafter. Patients were categorized into late recurrence (n=16) and long-term stable (n=139) groups.</p><p><strong>Methods: </strong>Clinical records and multimodal ophthalmic imaging were reviewed. Late recurrence was defined as reappearance of abnormal vessels and exudations occurring >12 months after documented complete resolution.</p><p><strong>Main outcome measures: </strong>Prevalence and time of late recurrence; baseline and recurrent clinical characteristics; treatment modalities; visual outcomes.</p><p><strong>Results: </strong>Late recurrence occurred in 10.3% of patients with a mean follow-up of 77.1 ± 37.8 months; mean recurrence-free interval was 53.4 ± 30.0 months (range, 15∼120 months). Recurrence rates varied by initial stage: 57.1% in stage 2A, 16.1% in stage 2B, 5.3% for stage 3A1, but none in stage 3A2, 3B and 4. The late recurrent group had a higher proportion of mild initial disease (87.5% vs 39.6%; P < 0.001), lower need for pars plana vitrectomy (PPV) (0% vs 46.8%, P < 0.001), and fewer quadrants of retinal damage after resolution (2.3 ± 1.0 vs 3.1 ± 1.0, P = 0.003) than the long-term stable group. All late recurrent patients received laser photocoagulation initially (100%), and 75% had visual improvement. Recurrent lesions were predominantly within the original abnormal area (87.5%), often manifesting as aneurysmal dilation (71.4%). Most recurrences (68.8%) were asymptomatic, detected on routine follow-up, and managed effectively with laser therapy to preserve visual function. In contrast, symptomatic patients (31.2%) presented with more advanced retinopathy, with widespread capillary leakage on fluorescein angiography (FA) beyond the zones of telangiectasia and exudation, and required more aggressive treatment (multiple laser sessions, intravitreal injections, or PPV).</p><p><strong>Conclusion: </strong>Late recurrence of Coats' disease can occur years after complete resolution, particularly in eyes with milder initial presentation, less aggressive primary treatment, less post-treatment retinal damage and better baseline visual acuity. Since most recurrences were asymptomatic, long-term follow-up is crucial for early detection and preventing severe retinopathy.</p>","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148813708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retinopathy in Dyskeratosis Congenita and Related Telomere Biology Disorders: Short Telomere Associated Retinopathy (STAR). 先天性角化不良和相关端粒生物学疾病的视网膜病变:短端粒相关视网膜病变(STAR)。
IF 5.9
Ophthalmology. Retina Pub Date : 2026-08-19 DOI: 10.1016/j.oret.2026.08.011
Karen W Jeng-Miller, Celine Chaaya, Samir N Patel, Aristomenis Thanos, Emmanuel Y Chang, Mrinali P Gupta, Shizuo Mukai, Dean Eliott, Alison Ann Bertuch, Suneet Agarwal, Nimesh A Patel, Yoshihiro Yonekawa
{"title":"Retinopathy in Dyskeratosis Congenita and Related Telomere Biology Disorders: Short Telomere Associated Retinopathy (STAR).","authors":"Karen W Jeng-Miller, Celine Chaaya, Samir N Patel, Aristomenis Thanos, Emmanuel Y Chang, Mrinali P Gupta, Shizuo Mukai, Dean Eliott, Alison Ann Bertuch, Suneet Agarwal, Nimesh A Patel, Yoshihiro Yonekawa","doi":"10.1016/j.oret.2026.08.011","DOIUrl":"https://doi.org/10.1016/j.oret.2026.08.011","url":null,"abstract":"<p><strong>Purpose: </strong>Dyskeratosis congenita (DC) and related telomere biology disorders (TBD) are rare hereditary conditions caused by genetic impairments of telomere maintenance. We present the largest study to date describing the vitreoretinopathy findings in TBDs and propose a new reflective terminology for the retinopathy.</p><p><strong>Design: </strong>This is a multicenter cross-sectional study describing the vitreoretinal findings of index patients and their affected family members with TBDs.</p><p><strong>Subjects: </strong>The study included forty-four eyes from 22 patients with TBDs.</p><p><strong>Methods: </strong>All participants underwent comprehensive ophthalmic examinations and imaging with widefield fluorescein angiography (WF-FA).</p><p><strong>Main outcome measures: </strong>The study aimed to quantify the prevalence and describe the characteristics of this rare associated vitreoretinopathy in patients with TBDs.</p><p><strong>Results: </strong>A total of 44 eyes from 22 patients were included (59.1% males). 18 (81.8%) patients were asymptomatic and found to have ophthalmic findings during screening examinations. 11 patients (50%) had inherited mutations, 22.7% were de novo mutations, and six patients having unknown inheritance patterns. Anterior segment findings included two patients (9.1%) with blepharitis, one with iris atrophy (4.5%), and one with iritis (4.5%). For posterior segment findings, all eyes had some combination of peripheral non-perfusion (100%), microaneurysmal changes (63.6%), telangiectasias (54.5%), fluorescein leakage (54.5%), sclerotic vessels (40.1%), retinal hemorrhages (36.3%), exudates (27.3%), retinal neovascularization (13.6%), and tractional retinal detachment (9.1%). We propose a staging system and discuss management strategies, including laser photocoagulation as the primary treatment, with adjunctive anti-VEGF agents for vascularly active eyes and vitreoretinal surgery for vitreous hemorrhage and retinal detachment.</p><p><strong>Conclusion: </strong>Contrary to prior assumptions, the retinovascular abnormalities in patients with TBDs, including DC, were universal in our cohort. Patients with retinopathy have been termed Revesz syndrome until now, but with the advent of WF-FA, we show that the retinopathy is likely more prevalent than previously thought. We propose that these findings be termed Short Telomere Associated Retinopathy (STAR) to reflect the underlying systemic pathophysiology. WF-FA facilitates diagnosis and management, with laser photocoagulation as the mainstay of treatment. Anti-VEGF and vitreoretinal surgery may be required depending on disease activity and severity.</p>","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148796174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Toward Multimodal Conversational AI for Age-Related Macular Degeneration. 针对老年性黄斑变性的多模态会话AI研究。
IF 5.9
Ophthalmology. Retina Pub Date : 2026-08-18 DOI: 10.1016/j.oret.2026.08.010
Ran Gu, Benjamin Hou, Mélanie Hébert, Asmita Indurkar, Yifan Yang, Emily Y Chew, Tiarnán D L Keenan, Zhiyong Lu
{"title":"Toward Multimodal Conversational AI for Age-Related Macular Degeneration.","authors":"Ran Gu, Benjamin Hou, Mélanie Hébert, Asmita Indurkar, Yifan Yang, Emily Y Chew, Tiarnán D L Keenan, Zhiyong Lu","doi":"10.1016/j.oret.2026.08.010","DOIUrl":"10.1016/j.oret.2026.08.010","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate OcularChat, an age-related macular degeneration (AMD)-specific multimodal large language model for interpreting color fundus photographs.</p><p><strong>Methods: </strong>A general-purpose multimodal large language model was fine-tuned using 705,850 simulated patient-physician dialogues paired with 46,167 AREDS images, then tested on separate AREDS and AREDS2 datasets.</p><p><strong>Results: </strong>In AREDS, OcularChat correctly classified advanced AMD, pigmentary abnormalities, and drusen size in 95.4%, 84.9%, and 67.8% of images, respectively. Retina specialists rated its responses more highly than those of the same model without fine-tuning.</p><p><strong>Conclusions: </strong>OcularChat gives the potential to support clinician-supervised, interpretable AMD image review, research annotation, and education, requiring prospective validation before clinical deployment.</p>","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148796139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Choroidal Amyloid Angiopathy with Fireworks Pattern on Late-Frames Indocyanine Green Angiography. 脉络膜淀粉样血管病伴晚帧吲哚菁绿血管造影烟花样。
IF 5.9
Ophthalmology. Retina Pub Date : 2026-08-17 DOI: 10.1016/j.oret.2026.07.011
Jennifer Cattaneo, Paolo Forte, Chiara M Eandi
{"title":"Choroidal Amyloid Angiopathy with Fireworks Pattern on Late-Frames Indocyanine Green Angiography.","authors":"Jennifer Cattaneo, Paolo Forte, Chiara M Eandi","doi":"10.1016/j.oret.2026.07.011","DOIUrl":"https://doi.org/10.1016/j.oret.2026.07.011","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148760727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信
小红书