Ophthalmology. Retina最新文献

{"title":"Mitochondrial Retinopathy Complicated with Choroidal Neovascularization","authors":"Kemal Tekin MD, Mehmet Yasin Teke MD","doi":"10.1016/j.oret.2025.08.001","DOIUrl":"10.1016/j.oret.2025.08.001","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":"10 5","pages":"Page e40"},"PeriodicalIF":5.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mycobacterium chimaera Choroiditis after Cardiac Surgery","authors":"Joanne Li MS , Christopher R. Fortenbach MD, PhD , Bobeck S. Modjtahedi MD","doi":"10.1016/j.oret.2025.08.015","DOIUrl":"10.1016/j.oret.2025.08.015","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":"10 5","pages":"Page e45"},"PeriodicalIF":5.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential 20-Week Faricimab Dosing in Wet Age-Related Macular Degeneration","authors":"Aude Ambresin MD, PD , Varun Chaudhary MD, FRCS(C) , Richard Gale MBChB, PhD , Adrian Hock Chuan Koh FRCS (Edin), FRCOphth , Nikolas J.S. London MD , Praveen J. Patel MD(Res), FRCOphth , Anna C.S. Tan MBBS, PhD , Lauren Hill MS , Aachal Kotecha PhD , Philippe Margaron PhD , Michael Singer MD","doi":"10.1016/j.oret.2026.02.001","DOIUrl":"10.1016/j.oret.2026.02.001","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":"10 5","pages":"Pages 573-575"},"PeriodicalIF":5.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146143049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of OPTic disc pIt MAculopathy","authors":"Mariantonia Ferrara MD ,&nbsp;Sabrina Vaccaro MD ,&nbsp;Boris Stanzel MD ,&nbsp;Roxane J. Hillier FRCOphth ,&nbsp;Marta Figueroa MD, PhD ,&nbsp;Tomaso Caporossi MD, PhD ,&nbsp;Grazia Pertile MD ,&nbsp;Mario R. Romano MD, PhD ,&nbsp;Stanislao Rizzo MD ,&nbsp;David H.W. Steel MD, FRCOphth","doi":"10.1016/j.oret.2025.12.008","DOIUrl":"10.1016/j.oret.2025.12.008","url":null,"abstract":"<div><h3>Purpose</h3><div>To evaluate long-term anatomical and visual outcomes after pars plana vitrectomy (PPV) combined with internal limiting membrane (ILM) flap in the treatment of optic disc pit maculopathy (ODPM).</div></div><div><h3>Design</h3><div>Multicenter, retrospective cohort study.</div></div><div><h3>Participants</h3><div>Patients with congenital ODPM who underwent primary or revisional PPV with ILM flap, with a minimum follow-up of 12 months.</div></div><div><h3>Methods</h3><div>Clinical data were retrospectively collected, including baseline characteristics, surgical details, fluid distribution, central macular thickness (CMT), and best-corrected visual acuity (BCVA) at baseline and at 1, 6, and 12 months postoperatively, as well as at the final follow-up.</div></div><div><h3>Main Outcomes Measures</h3><div>The primary outcome was the rate of anatomical resolution (defined as complete reabsorption of intraretinal fluid and subretinal fluid [SRF]) at 12 months. Secondary outcomes included anatomical resolution at last follow-up, change in CMT and BCVA, fluid distribution patterns, and identification of predictors of treatment response.</div></div><div><h3>Results</h3><div>A total of 71 eyes from 71 patients were included. Complete resolution was achieved in 33.8% of cases at 12 months, increasing to 57.7% at a median follow-up of 24 months. An additional 19.7% showed anatomical improvement. Mean CMT decreased significantly (from 639.5 <em>μ</em>m to 316.7 <em>μ</em>m at 12 months and 297.2 <em>μ</em>m at final follow-up, <em>P</em> &lt; 0.0001 for both), and median BCVA improved from 0.6 (20/80) to 0.3 (20/40) logarithm of the minimum angle of resolution (LogMAR) at both 12-month and final follow-up (<em>P</em> &lt; 0.001). Anatomical and visual outcomes were comparable between primary and revisional surgeries. Multivariate analysis revealed that female sex (odds ratio [OR] = 5.7, <em>P</em> = 0.008) and presence of SRF only (OR = 8.0, <em>P</em> = 0.005) were independent predictors of complete resolution. Subretinal fluid-only configuration was also significantly associated with ≥0.2 LogMAR (2 Snellen lines) visual gain (OR = 5.0, <em>P</em> = 0.038). Intraoperative laser to optic disc edge was negatively associated with visual improvement (OR = 3.5, <em>P</em> = 0.048).</div></div><div><h3>Conclusions</h3><div>Pars plana vitrectomy with ILM flap offers favorable long-term anatomical and functional outcomes for ODPM, thus representing an effective treatment, in particular in revision cases. The presence of isolated SRF appears to be a positive prognostic marker for both anatomical and visual recovery. In contrast, adjunctive laser photocoagulation may negatively impact visual recovery. Our findings support caution against unnecessary early reoperation.</div></div><div><h3>Financial Disclosure(s)</h3><div>The authors have no proprietary or commercial interest in any materials discussed in this article.</div></div>","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":"10 5","pages":"Pages 508-520"},"PeriodicalIF":5.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145804732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"Simon K.H. Szeto FRCOphth ,&nbsp;Julia T.W. Lam MBChB ,&nbsp;Chi Wai Tsang FCOphth (HK) ,&nbsp;Marcin Stopa FEBO","doi":"10.1016/j.oret.2026.02.008","DOIUrl":"10.1016/j.oret.2026.02.008","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":"10 5","pages":"Pages e36-e37"},"PeriodicalIF":5.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147326811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fingerprint Sign in Familial Microphthalmia Linked to Membrane Frizzled-Related Protein Mutation","authors":"Gonzalo Roig-Ferreruela MD ,&nbsp;María Magdalena Alberto-Pestano MD ,&nbsp;Jaume Català-Mora MD, PhD","doi":"10.1016/j.oret.2025.08.012","DOIUrl":"10.1016/j.oret.2025.08.012","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":"10 5","pages":"Page e44"},"PeriodicalIF":5.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cost Analysis of Risk-Stratified Retinopathy of Prematurity Screening","authors":"Hannah H. Hwang MD ,&nbsp;Angelica Piccini BS ,&nbsp;Muhammad Abidi BS ,&nbsp;Francisco Altamirano MD ,&nbsp;Daniel Hu BA ,&nbsp;Sandra Hoyek MD ,&nbsp;Celine Chaaya MD, MSc ,&nbsp;Melissa Yuan MD ,&nbsp;Mahmoudinezhad Golnoush MD, MPH ,&nbsp;Audina M. Berrocal MD ,&nbsp;Efren Gonzalez MD ,&nbsp;Ryan Gise MD ,&nbsp;Deborah K. Vanderveen MD ,&nbsp;Nimesh A. Patel MD","doi":"10.1016/j.oret.2025.12.021","DOIUrl":"10.1016/j.oret.2025.12.021","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":"10 5","pages":"Pages 575-579"},"PeriodicalIF":5.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145889830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-Resolution OCT of Presumed Basal Laminar Deposit and RPE Abnormalities in Extensive Macular Atrophy with Pseudodrusen-like Appearance.","authors":"Alberto Quarta, Francesco Romano, Mai Alhelaly, Alessandro Feo, Rouzbeh Abbasgholizadeh, Shinichiro Chujo, Claudia Nardi, Andrea Trinco, Paolo Forte, Jianfeng Huang, Ceren Soylu, Giulia Corradetti, Federico Corvi, David Sarraf, Giovanni Staurenghi, Srinivas R Sadda","doi":"10.1016/j.oret.2026.04.020","DOIUrl":"https://doi.org/10.1016/j.oret.2026.04.020","url":null,"abstract":"<p><strong>Purpose: </strong>To characterize the morphologic spectrum and co-occurrence of basal laminar deposit (BLamD) and abnormal retinal pigment epithelium (RPE) in eyes with extensive macular atrophy with pseudodrusen (EMAP) using High-Resolution optical coherence tomography (OCT).</p><p><strong>Design: </strong>Cross-sectional observational study.</p><p><strong>Participants: </strong>Forty-eight eyes from 25 patients (13 female, 12 male; mean age, 61.7 ± 3.9 years; range, 53-71 years) with EMAP.</p><p><strong>Methods: </strong>All participants underwent multimodal imaging, including high-resolution spectral-domain OCT, fundus autofluorescence, and swept-source OCT angiography. Morphologic and histologically informed BLamD -like deposits, RPE abnormalities, subretinal drusenoid deposits (SDD) over BLamD, and intraretinal hyperreflective foci (IHRF) were assessed categorically as present or absent. Descriptive statistics were used to summarize overall prevalence and co-occurrence of the various features.</p><p><strong>Main outcome measures: </strong>Frequency and distribution of OCT-derived structural features associated with RPE-Bruch's membrane complex alterations and outer retinal atrophy.</p><p><strong>Results: </strong>Persistent BLamD was identified in 39/48 eyes (81.3%), and scalloped BLamD in 31/48 eyes (64.6%). RPE abnormality was present in 21/48 eyes (43.8%), IHRF in 27 eyes (56.3%), and SDD overlying BLamD in 27/48 eyes (56.3%). Eyes with scalloped BLamD numerically more frequent showed RPE abnormalities (67.7% vs. 0%), IHRF (71.0% vs. 29.4%), and SDD over BLamD (74.2% vs. 23.5%) compared to eyes with Persistent BLamD. Eyes with RPE abnormality universally also demonstrated IHRF (100%) and Persistent BLamD (95.2%), suggesting that these features may also be markers of RPE distress. Foveal involvement of atrophy was observed in 48.9% of eyes, with irregular RPE observed in 20.8% of eyes, IHRF in 33.3%, BLamD in 91.7%, scalloped BLamD in 45.8%, and SDD overlying BLamD in 37.5%.</p><p><strong>Conclusions: </strong>High-Res OCT reveals that BLamD and abnormal/spikey RPE are highly prevalent in EMAP. Distinct BLamD phenotypes can be appreciated in EMAP and scalloped BLamD was frequently associated with RPE abnormality, IHRF, and SDD, suggesting it is associated with features typically interpreted as more advanced local degeneration. Recognition of these phenotypes may enhance structural staging in EMAP.</p>","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147818366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ciliary Body Medulloepithelioma Presenting as Leukocoria.","authors":"Yang Meng, Sainan Xiao, Tao Li","doi":"10.1016/j.oret.2026.04.003","DOIUrl":"https://doi.org/10.1016/j.oret.2026.04.003","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147777643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Niveau (level) as a key predictor for the absence of macular hole in sub-ILM hemorrhage secondary to retinal arterial macroaneurysm rupture.","authors":"Yuki Otsuka, Miou Hirose, Hideyasu Oh","doi":"10.1016/j.oret.2026.04.018","DOIUrl":"https://doi.org/10.1016/j.oret.2026.04.018","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the risk factors of macular hole (MH) in patients with retinal arterial macroaneurysm (RAM) rupture.</p><p><strong>Design: </strong>Retrospective observational cohort study.</p><p><strong>Participants: </strong>We reviewed the records of patients with RAM rupture who underwent pars plana vitrectomy (PPV) at Hyogo Prefectural Amagasaki General Medical Center between December 2015 and December 2024. We included consecutive cases with sub-internal limiting membrane (sub-ILM) hemorrhage covering the fovea and with unclear macular hole (MH) status on optical coherence tomography (OCT) before surgery.</p><p><strong>Methods: </strong>The following data were extracted from the medical records: age, sex, duration between onset and first examination or surgery, axial length, preoperative best-corrected visual acuity (BCVA), systemic hypertension and diabetes mellitus, oral administration of antiplatelets and anticoagulants, RAM location (superior or inferior to the fovea), distance from the RAM to the fovea, presence of a niveau (fluid level) in sub-ILM hemorrhage, fluffy sign, foveal mountain peak (FMP) sign, and type of surgical procedure (vitrectomy system [25/27 gauge], combined cataract surgery, subretinal tissue plasminogen activator [t-PA] injection, and sulfur hexafluoride gas tamponade).</p><p><strong>Main outcome measures: </strong>The presence of MH in patients with RAM rupture.</p><p><strong>Results: </strong>Thirty-nine patients were included in this study. MH was observed in 14 patients (35.9%). Fluid level in sub-ILM hemorrhage was observed in 92.0% and 14.3% of the patients without and with MH, respectively. The absence of fluid level was associated with the presence of MH (p < 0.01). Subretinal injection of t-PA was more frequently administered to patients with MH (p = 0.027). However, multivariate logistic regression analysis revealed that only fluid level in sub-ILM hemorrhage was significantly associated with MH development (p < 0.01; risk ratio = 0.0033; 95% confidence interval = -12.1 to -2.6).</p><p><strong>Conclusions: </strong>The absence of fluid level in sub-ILM hemorrhage was associated with MH development. Fluid level in sub-ILM hemorrhage is a useful predictive factor of MH in patients with RAM rupture.</p>","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147818460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}