Ophthalmology. Retina最新文献

{"title":"Outer Retinal Tubulations in Bietti Crystalline Dystrophy","authors":"Shiyi Yin MMed , Jinyuan Wang MD , Wenbin Wei PhD","doi":"10.1016/j.oret.2024.07.018","DOIUrl":"10.1016/j.oret.2024.07.018","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":"9 3","pages":"Page e22"},"PeriodicalIF":4.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142056220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interreader and Intermodality Variability in Macular Atrophy Quantification in Neovascular Age-related Macular Degeneration","authors":"Enrico Borrelli MD, PhD , Chiara Olivieri MD , Sonia Serafino MD , Andrea Coletto MD , Federico Ricardi MD , Giovanni Neri MD , Paola Marolo MD , Michele Reibaldi MD, PhD","doi":"10.1016/j.oret.2024.08.017","DOIUrl":"10.1016/j.oret.2024.08.017","url":null,"abstract":"<div><h3>Purpose</h3><div>Macular atrophy is a common complication in neovascular age-related macular degeneration (AMD) and is associated with poorer visual outcomes. This study evaluated interreader and intermodality variability in measuring macular atrophy in previously treated neovascular AMD eyes without exudation using 6 imaging modalities.</div></div><div><h3>Design</h3><div>Prospective, cohort study.</div></div><div><h3>Participants</h3><div>Thirty participants with previously treated neovascular AMD showing no signs of exudation at the time of enrollment and exhibiting macular atrophy.</div></div><div><h3>Methods</h3><div>During the same clinic visit, patients were imaged using 6 different imaging modalities: color fundus photography (CFP; Clarus, Carl Zeiss Meditec), near-infrared imaging (NIR; Spectralis, Heidelberg Engineering), structural OCT (Spectralis, Heidelberg Engineering), green fundus autofluorescence (GAF; Clarus, Carl Zeiss Meditec), blue fundus autofluorescence (BAF; Spectralis, Heidelberg Engineering), and pseudocolor imaging (MultiColor; Spectralis, Heidelberg Engineering). Two readers independently measured the macular atrophy area.</div></div><div><h3>Main Outcome Measures</h3><div>Interreader and intermodality agreement.</div></div><div><h3>Results</h3><div>The 95% coefficient of repeatability was 5.98 mm<sup>2</sup> for CFP, 4.46 mm<sup>2</sup> for MultiColor, 3.90 mm<sup>2</sup> for BAF, 3.92 mm<sup>2</sup> for GAF, 4.86 mm<sup>2</sup> for NIR, and 3.55 mm<sup>2</sup> for OCT. Similarly, the coefficient of variation was lowest for OCT-based grading at 0.08 and highest for NIR-based grading at 0.28. Accordingly, the intraclass correlation coefficient was 0.742 for CFP, 0.805 for MultiColor, 0.857 for BAF, 0.850 for GAF, 0.755 for NIR, and 0.917 for OCT. The 6 different imaging modalities presented measurements with different mean values, with only a limited number of comparisons not significantly different between the instruments, although measurements were correlated. The largest size of macular atrophy was measured with structural OCT-based grading (median = 4.65 mm<sup>2</sup>; interquartile range [IQR] = 4.78 mm<sup>2</sup>) and the smallest was with CFP-based grading (median = 3.86 mm<sup>2</sup>; IQR = 5.06 mm<sup>2</sup>). Inconsistencies arose from various factors.</div></div><div><h3>Conclusions</h3><div>In patients with neovascular AMD, macular atrophy measurements vary significantly depending on the imaging technique used. Color fundus photography–based assessments yielded the smallest macular atrophy sizes, whereas structural OCT-based assessments produced the largest. These discrepancies stem from both the inherent limitations of each modality in assessing retinal pigment epithelial atrophy and factors related to neovascularization, such as the coexistence of fibrosis.</div></div><div><h3>Financial Disclosure(s)</h3><div>Proprietary or commercial disclosure may be found in the Footnotes and Disclosures a","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":"9 3","pages":"Pages 212-223"},"PeriodicalIF":4.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142110360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amoeboid Retinal Lesions and Macular Atrophy in RDH12 Mutation","authors":"Marina Ger MS, Srikanta Kumar Padhy MD","doi":"10.1016/j.oret.2024.07.019","DOIUrl":"10.1016/j.oret.2024.07.019","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":"9 3","pages":"Page e23"},"PeriodicalIF":4.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142056218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intravitreal Antibiotics versus Early Vitrectomy Plus Intravitreal Antibiotics for Postinjection Endophthalmitis","authors":"Connor J. Ross BS ,&nbsp;Sophia Ghauri BS ,&nbsp;Joshua B. Gilbert EdM ,&nbsp;Daniel Hu BA ,&nbsp;Varun Ullanat MS ,&nbsp;Dan Gong MD ,&nbsp;Paul B. Greenberg MD, MPH ,&nbsp;Dean Eliott MD ,&nbsp;Tobias Elze PhD ,&nbsp;Alice Lorch MD, MPH ,&nbsp;Joan W. Miller MD ,&nbsp;Magdalena G. Krzystolik MD","doi":"10.1016/j.oret.2024.09.002","DOIUrl":"10.1016/j.oret.2024.09.002","url":null,"abstract":"<div><h3>Purpose</h3><div>To determine if intravitreal injection of antibiotics alone versus early pars plana vitrectomy (PPV) plus injection of intravitreal antibiotics predicted better or worse visual outcomes for patients with endophthalmitis after anti-VEGF injections.</div></div><div><h3>Design</h3><div>Retrospective cohort study.</div></div><div><h3>Participants</h3><div>Patients developing endophthalmitis after receiving an intravitreal anti-VEGF injection from the American Academy of Ophthalmology IRIS® (Intelligent Research in Sight) Registry between 2016 and 2020.</div></div><div><h3>Methods</h3><div>Inclusion criteria were endophthalmitis diagnosis within 1 to 28 days after anti-VEGF injection and a recorded visual acuity (VA) at baseline, on the day of diagnosis, and posttreatment. Patients in the Injection Only group underwent intravitreal injection of antibiotics alone and in the Early Vitrectomy group received PPV with intravitreal antibiotics or intravitreal injection followed by PPV within 2 days of diagnosis. Patients were excluded if they had cataract surgery during the study, intravitreal steroids before endophthalmitis, or intermediate/posterior uveitis or cystoid macular edema. The study created a 1:1 matched cohort using Mahalanobis distance matching, accounting for the differences in VA at baseline and diagnosis.</div></div><div><h3>Main Outcome Measures</h3><div>Posttreatment logarithm of the minimum angle of resolution (logMAR) VA.</div></div><div><h3>Results</h3><div>A total of 1044 patients diagnosed with postinjection endophthalmitis met the inclusion and exclusion criteria. In the unmatched cohort, there were 935 patients in the Injection Only and 109 in the Early Vitrectomy group. In 1:1 matched cohort, 218 patients (109 in each group) were included; the median logMAR VAs were 0.32 (20/40–20/50) at baseline, 0.88 (∼20/150) at diagnosis, and 0.57 (20/70–20/80) posttreatment. There were no statistically significant differences in the visual outcomes between the 2 matched treatment groups (<em>b</em> = 0.05; <em>P</em> = 0.23); including the subgroup of patients with VA worse than 1.0 logMAR (<em>b</em> = 0.05; <em>P</em> = 0.452).</div></div><div><h3>Conclusions</h3><div>There was no significant difference in final VA outcomes between patients receiving Injection Only and those treated with Early Vitrectomy for postinjection endophthalmitis. The findings support the use of either treatment strategy.</div></div><div><h3>Financial Disclosure(s)</h3><div>Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.</div></div>","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":"9 3","pages":"Pages 224-231"},"PeriodicalIF":4.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Internal Limiting Membrane Peeling for Large Macular Holes Induces Only Structural Remodeling without Functional Impairment Over 12 Years","authors":"Thibaud Garcin MD, PhD ,&nbsp;Alain Gaudric MD, PhD ,&nbsp;Anne Sikorav MD ,&nbsp;Ramin Tadayoni MD, PhD ,&nbsp;Aude Couturier MD, PhD","doi":"10.1016/j.oret.2024.09.005","DOIUrl":"10.1016/j.oret.2024.09.005","url":null,"abstract":"<div><h3>Purpose</h3><div>To evaluate the very long-term functional and structural outcomes of internal limiting membrane (ILM) peeling for full-thickness macular holes (FTMH).</div></div><div><h3>Design</h3><div>Observational case series nested within a multicenter, randomized, controlled clinical trial (RCT) (ClinicalTrials.gov: <span><span>NCT00190190</span><svg><path></path></svg></span>).</div></div><div><h3>Subjects</h3><div>Patients who underwent vitrectomy with or without ILM peeling for an idiopathic large FTMH in a tertiary ophthalmology center, with a minimum follow-up of 10 years after surgery.</div></div><div><h3>Methods</h3><div>Review of charts, spectral-domain OCT (SD-OCT) scans, OCT angiography (OCTA) scans, and microperimetry of patients originally enrolled in the RCT.</div></div><div><h3>Main Outcome Measures</h3><div>Primary outcome was functional assessment in both groups (ILM peeling or not) including the retinal sensitivity (RS), distance and near best-corrected visual acuity (BCVA), and number of eyes achieving ≥0.3 logarithm of the minimum angle of resolution &gt;10 years after surgery. Secondary outcomes were structural assessment in the entire 3 × 3-mm and 6 × 6-mm areas, and regionally in the different areas of the ETDRS grid: OCT and OCTA biomarkers in both groups and fellow eyes.</div></div><div><h3>Results</h3><div>Thirteen eyes of 13 patients with a mean follow-up of 12 ± 0.73 years were included. The mean RS and BCVA, or visual improvement did not differ between ILM peeling (n = 8) and no peeling (n = 5) (all <em>P</em> &gt; 0.05). The dissociated optic nerve fiber layers on en face OCT were only observed in eyes with ILM peeling, predominantly in temporal parafoveal (20%) and perifoveal (19%) rings. The mean total retinal thickness and inner retinal thickness in the parafoveal ring were significantly lower in peeled eyes (309 ± 11 μm and 94 ± 9 μm respectively) versus nonpeeled eyes (330 ± 21 μm and 108 ± 11 μm respectively; <em>P</em> = 0.037 and <em>P</em> = 0.040), without significant difference in ganglion cell or retinal nerve fiber layers. Accordingly, the mean superficial capillary plexus density in the parafoveal ring was significantly lower in eyes with peeling versus without (39.65 ± 3.76% versus 47.22 ± 4.00; P = 0.005). The mean foveal avascular zone area was smaller in eyes with peeling versus without (0.24 ± 0.05 mm² vs. 0.42 ± 0.13 mm², respectively, <em>P</em> = 0.005).</div></div><div><h3>Conclusions</h3><div>Despite persistent structural changes especially in the parafoveal ring, ILM peeling for idiopathic large FTMH did not seem to impact long-term RS or BCVA over 12 years.</div></div><div><h3>Financial Disclosure(s)</h3><div>Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.</div></div>","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":"9 3","pages":"Pages 253-262"},"PeriodicalIF":4.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endophthalmitis following pars plana vitrectomy: An 11-year retrospective cohort of 36,179 procedures in London, United Kingdom.","authors":"Siegfried K Wagner, Harry Petrushkin, Asterios Diafas, Achini Makuloluwa, Lyndon da Cruz, Mahiul Mk Muqit","doi":"10.1016/j.oret.2025.02.025","DOIUrl":"https://doi.org/10.1016/j.oret.2025.02.025","url":null,"abstract":"<p><strong>Objective: </strong>Endophthalmitis is a rare but devastating complication of pars plana vitrectomy (PPV). We assessed the incidence and profile of post-PPV exogenous endophthalmitis and investigated causality and prognostic factors in a large ethnically diverse cohort over an 11-year period.</p><p><strong>Design: </strong>A retrospective single-site cohort study.</p><p><strong>Participants: </strong>Adult patients (aged 18 and over) undergoing PPV at Moorfields Eye Hospital.</p><p><strong>Methods: </strong>PPV procedures between January 1st 2013 and January 1st 2024 were extracted from the electronic health record and cross-referenced with all endophthalmitis cases using clinical documentation, prescription records, and incident reports.</p><p><strong>Main outcome measures: </strong>The incidence proportion was estimated and stratified by additional procedures during PPV. Odds ratios (OR) with 95% confidence intervals (CI) for the association between endophthalmitis incidence and sociodemographic and procedural factors were estimated using univariable and multivariable logistic regression models.</p><p><strong>Results: </strong>There were 36,179 procedures from 26,533 patients included in the analysis. The overall incidence of post-PPV endophthalmitis was 0.05% (n=19), of which 63.2% (n=12) were culture-positive. Five cases occurred after 28 days, of which three had coexisting anterior segment pathology including corneal abscesses and loose sutures. Incidence figures varied from 0.05% in PPV with internal limiting membrane peel to 0.65% in those undergoing intraocular lens (IOL) exchange. Higher odds of endophthalmitis were seen with fluid tamponade (adjusted OR [aOR] 5.70, 95% CI: 1.80, 18.03, p = 0.003) and increasingly complex secondary IOL procedures - secondary IOL insertion alone (aOR 5.42, 95% CI: 1.23, 23.97, p=0.026); IOL removal (aOR 9.81, 95% CI: 3.10, 31.07, p=1.0 x 10^-4); and, IOL exchange (aOR 13.64, 95% CI: 4.29, 43.43, p=9.7 x 10^-6). When adjusting for tamponade, IOL removal (aOR: 4.64, 95% CI: 1.14, 18.86, p = 0.032) and IOL exchange (aOR 6.24, 95% CI: 1.43, 27.27, p=0.015) remained significantly associated with endophthalmitis. Endophthalmitis associated with secondary IOL procedures were all culture-positive (n=3 Staphylococcus spp, n=3 Streptococcus spp).</p><p><strong>Conclusions: </strong>Although post-PPV exogenous endophthalmitis is rare, individuals undergoing PPV with IOL removal and exchange have a considerably increased odds of developing endophthalmitis. Delayed cases of endophthalmitis frequently have coexisting anterior segment pathology.</p>","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patching with Amniotic Membrane in Gunshot Globe Perforation Retinal Detachment.","authors":"Helena Proença, Carlos Marques-Neves, Barbara Parolini","doi":"10.1016/j.oret.2025.02.001","DOIUrl":"https://doi.org/10.1016/j.oret.2025.02.001","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SPONTANEOUS SOFT DRUSEN REGRESSION WITHOUT ATROPHY AND THE DRUSEN OOZE.","authors":"Jordi Monés, Fernando Pagani, Juan Francisco Santamaria, Miriam Garcia, Cristina Romero, Daniel Garcia, Anna Serrano, Alicia Carrasco","doi":"10.1016/j.oret.2025.02.023","DOIUrl":"https://doi.org/10.1016/j.oret.2025.02.023","url":null,"abstract":"<p><strong>Objective or purpose: </strong>To determine the incidence of spontaneous soft drusen regression without atrophy (DRwoA) in patients with intermediate or atrophic age-related macular degeneration (iAMD, aAMD) and evaluate associated events and offer potential explanations.</p><p><strong>Design: </strong>A retrospective review of the imaging of a consecutive series of 640 eyes from 320 patients with AMD who had at least 2 years of follow-up.</p><p><strong>Subjects: </strong>427 eyes from 262 patients with iAMD or aAMD and no present or past exudative AMD.</p><p><strong>Methods: </strong>Retinal imaging included infrared reflectance imaging (IR), fundus autofluorescence (FAF), spectral-domain OCT (SD-OCT), and color fundus photography (CFP).</p><p><strong>Main outcome measures: </strong>Drusen regression without atrophy (DRwoA) with integrity of the retinal pigment epithelium (RPE) and repositioning over Bruch's membrane. Additionally, drusen that would collapse with atrophy (DCwA) in the same area simultaneously were named \"sentinel\" DCwA. The reversibility of features of incomplete retinal pigment epithelium and outer retinal atrophy (iRORA), as well as areas (\"halos\") of DRwoA around the \"sentinel\" drusen.</p><p><strong>Results: </strong>Among the 427 eyes, 53 events of DRwoA were found, representing 24,17% of the eyes with soft drusen. In 50 cases (94,33%), a \"sentinel\" DCwA in the vicinity was found. In 58% of the cases, a well-identifiable halo of drusen disappearance around the \"sentinel\" DCwA was well visible.</p><p><strong>Conclusions: </strong>DRwoA is a frequently observed phenomenon linked to soft drusen and almost invariably occurs near a \"sentinel\" DCwA. The coalescence of the drusen and the spatial and temporal association of the DRwaA and the DCwA strongly suggest that the drusen material of DRwoA escapes to a contiguous \"sentinel\" DCwA. While the hypothesis of the disappearance of drusen material due to RPE death may explain the DCwA, it fails to account for DRwoA. Instead, the \"drusen ooze\" hypothesis, which posits the movement of drusen content to the subretinal space through RPE defects, may explain both the DCwA and the DRwoA. This hypothesis offers insights into the reversibility of iRORA features and suggests that therapies targeting drusen material removal before RPE disruptions could potentially prevent atrophy secondary to soft drusen collapse.</p>","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Age-related Macular Degeneration and mortality in a high cardiovascular risk cohort: A prospective cohort study.","authors":"Richard Kha, George Burlutsky, Aravinda Thiagalingam, Pramesh Kovoor, Joseph Chiha, Paul Mitchell, Gerald Liew","doi":"10.1016/j.oret.2025.02.024","DOIUrl":"https://doi.org/10.1016/j.oret.2025.02.024","url":null,"abstract":"<p><strong>Objective: </strong>-To investigate if age-related macular degeneration (AMD) predicts risk of all-cause and cardiovascular disease (CVD) mortality in a high CVD risk cohort.</p><p><strong>Design: </strong>- Prospective cohort study PARTICIPANTS: - 1545 adult participants who presented to a tertiary Australian hospital for evaluation of acute coronary syndrome were included in this study.</p><p><strong>Methods: </strong>- Participants were evaluated for acute coronary syndrome using coronary angiography. Participants were concurrently examined for AMD from mydriatic fundus photographs which were graded using the Wisconsin grading system into categories of any AMD, early AMD and late AMD. Coronary artery disease (CAD) was graded from coronary angiograms using the Gensini score. Mortality data were obtained 9 years after baseline examination through data linkage with the Australian National Death Index. Hazard ratios (HR) were obtained using Cox regression analysis.</p><p><strong>Main outcome measures: </strong>All-cause and CVD mortality data were obtained through data linkage with the Australian National Death Index. Death rates through June 2018 were compared by demographics and potential confounders.</p><p><strong>Results: </strong>- Any AMD was identified in 107 (6.9%) participants, including those with early (n=86) and late AMD (n=21). Over 9 years of follow-up, 234 (15.1%) participants had died, including 174 (11.3%) participants from fatal CVD events. After controlling for age, sex, body mass index , total cholesterol, smoking status, history of diabetes, hypertension, myocardial infarction, stroke and macrovascular CAD severity using the Gensini score, there was an increased rate of all-cause mortality for those with any AMD (hazard ratio [HR] 2.37, [95% CI: 1.54-3.64]), early AMD (HR 2.42 [1.48-3.94]) and late AMD (HR 2.25 [1.08-4.71]). Any AMD (HR 2.62, [1.61-4.26]) and early AMD (HR 2.61 [1.50-4.64]) were also associated with a greater likelihood of CVD mortality. Late AMD was not associated with CVD mortality.</p><p><strong>Conclusions: </strong>- In individuals with high CVD risk, presence of AMD at any stage independently predicted increased all-cause mortality. Meanwhile, any and early AMD increased risk of CVD mortality. Although mechanisms are unclear, this potentially reflects shared pathways between AMD and CVD.</p>","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rhegmatogenous Retinal Detachment Hiding an Underlying Choroidal Melanoma.","authors":"Gabrielle E Kozlowski, Hidayet Sener, Carol L Shields","doi":"10.1016/j.oret.2025.01.018","DOIUrl":"https://doi.org/10.1016/j.oret.2025.01.018","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}