Ophthalmology. Retina最新文献

{"title":"Best Vitelliform Macular Dystrophy Natural History Study Report 2: Fundus Autofluorescence and Optical Coherence Tomography.","authors":"Yannik Laich, Michalis Georgiou, Kaoru Fujinami, Malena Daich Varela, Yu Fujinami-Yokokawa, Shaima Awadh Hashem, Thales A C de Guimaraes, Omar A Mahroo, Andrew R Webster, Michel Michaelides","doi":"10.1016/j.oret.2025.03.004","DOIUrl":"https://doi.org/10.1016/j.oret.2025.03.004","url":null,"abstract":"<p><strong>Purpose: </strong>To analyze the retinal imaging findings and natural history of Best vitelliform macular dystrophy (BVMD).</p><p><strong>Design: </strong>Single-center retrospective, consecutive, observational study.</p><p><strong>Participants: </strong>Patients with a clinical diagnosis of BVMD, from pedigrees with a likely disease-causing monoallelic variant in BEST1.</p><p><strong>Methods: </strong>Data were extracted from electronic and physical case notes. Retinal imaging with optical coherence tomography (OCT) and fundus autofluorescence (FAF) was analyzed cross-sectionally and longitudinally.</p><p><strong>Main outcome measurements: </strong>Qualitative and quantitative OCT and FAF analysis.</p><p><strong>Results: </strong>222 patients (127 males and 95 females) from 141 families were included. Mean central retinal thickness on OCT at baseline was 337.2 μm for the right eye and 341.1 μm for the left eye, with a mean annual thickness loss of 5.7 μm and 5.2 μm respectively. The presence of the OCT features: pre-vitelliform lesion, solid vitelliform lesion, vitelliform lesion with subretinal fluid and focal choroidal excavation were associated with a better mean visual acuity (VA), whereas the presence of intraretinal fluid and atrophy/fibrosis were correlated with a worse mean VA. FAF showed an area of hyperautofluorescence at the posterior pole in 138 eyes (34.7%), a circumscribed area of hyperautofluorescence superior or superotemporal of the optic nerve head in 53 eyes (13.3%), fibrotic changes in 48 eyes (12.1%) and atrophy in 41 eyes (10.3%).</p><p><strong>Conclusions: </strong>BVMD shows a wide spectrum of phenotypes on OCT and FAF imaging. The slow and variable disease course may pose a challenge in identification of early endpoints for therapeutic trials aimed at altering kinetics of degeneration.</p>","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinal Detachment and Macular Hole in Acute Retinal Necrosis Treated with Human Amniotic Membrane.","authors":"Federica Fossataro, Salvatore Parrulli, Matteo Giuseppe Cereda","doi":"10.1016/j.oret.2025.02.012","DOIUrl":"https://doi.org/10.1016/j.oret.2025.02.012","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adherence to Hydroxychloroquine Dosing Guidelines at the University of California.","authors":"Kareem Moussa, Jaipreet S Virk, Brian Paciotti, Blythe P Durbin-Johnson, Jessica G Shantha, Edmund Tsui, Catherine Q Sun, Sally L Baxter, Charlotte Gore, Glenn Y Yiu","doi":"10.1016/j.oret.2025.03.003","DOIUrl":"https://doi.org/10.1016/j.oret.2025.03.003","url":null,"abstract":"<p><p>The American Academy of Ophthalmology has published several guidelines on dosing and screening recommendations for hydroxychloroquine. In this cross-sectional study we report 36% of patients prescribed hydroxychloroquine at the University of California are excessively dosed.</p>","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143616664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk and Dose-Response Relationship for Pentosan Polysulfate Sodium Maculopathy: A Systematic Review and Meta-Analysis.","authors":"Brendan K Tao, Korolos Sawires, Kate Lim, Fahad Butt, Thanansayan Dhivagaran, R Rishi Gupta, Amit Mishra","doi":"10.1016/j.oret.2025.03.001","DOIUrl":"https://doi.org/10.1016/j.oret.2025.03.001","url":null,"abstract":"<p><strong>Topic: </strong>To determine the pooled relative risk (RR) of Pentosan Phosphate Sodium Maculopathy (PPSM) in patients using PPS and model the dose-response relationship of this association from existing literature.</p><p><strong>Clinical relevance: </strong>PPSM is an acquired, progressive retinal pigmentary disease associated with oral PPS use. Though several observational studies suggest a dose-response relationship of this association, to-date, there remains no literature-pooled synthesis on risk of PPSM across strata of cumulative dose.</p><p><strong>Methods/literature reviewed: </strong>Systematic review and meta-analysis (CRD42024623179). Medline, Embase, and CENTRAL were searched from inception to September 15, 2024. We included studies reporting the incidence of PPS-associated maculopathy and including cumulative PPS dose information. Two independent reviewers completed study screening, data extraction and risk of bias (ROB) assessment using the Risk of Bias in Non-randomized Studies of Exposures (ROBINS-E) tool, a third reviewer was consulted to resolve conflicts. The primary outcome was the relative risk of PPSM among patients exposed to PPS compared to non-exposed individuals, stratified by cumulative PPS dose.</p><p><strong>Results: </strong>We included five studies encompassing 141,785 patients and 6,432 PPSM cases. The linear dose-response regression model estimated a 0.1% increase in RR of maculopathy per g increase in cumulative PPS dose (logRR = 0.00101, 95% CI: 0.0005-0.0015, p < 0.0001). Patients with cumulative doses ≥2,000 g exhibited a RR of 7.39 (95% CI: 4.17-13.10), while those with a dose between 1-500 g had a RR of 1.65 (95% CI: 1.12-2.43) compared to non-exposed individuals. Subgroup analysis excluding high-risk studies demonstrated consistent findings, with reduced heterogeneity (I² = 63.7%).</p><p><strong>Conclusion: </strong>Moderate certainty evidence supports a dose-dependent relationship between PPS exposure and PPSM risk, whereas higher cumulative doses significantly increase maculopathy risk. This result supports that patients should be tapered to an effective minimal dose and that they should be subject to interval maculopathy screening, especially for patients with greater cumulative dose. Future research should incorporate patient-level data to better control for potential confounding.</p>","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143616649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Benign Lobular Inner Nuclear Layer Proliferations.","authors":"Ozgur Yalcinbayir, Gamze Ucan Gunduz, Deniz Yalcinbayir","doi":"10.1016/j.oret.2025.02.011","DOIUrl":"https://doi.org/10.1016/j.oret.2025.02.011","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraocular Inflammation After Aflibercept Prefilled Syringe and Vial Injections.","authors":"David M Brown, Rachel E Sobel, Kiliana Suzart-Woischnik, Nick Boucher, Julius Asubonteng, Hadi Moini, Nitika Aggarwal, Suzanne Green, Angelika Manthripragada","doi":"10.1016/j.oret.2025.03.002","DOIUrl":"https://doi.org/10.1016/j.oret.2025.03.002","url":null,"abstract":"<p><p>In this observational cohort study, incidence of intraocular inflammation following intravitreal injection in the Vestrum Health database was significantly lower with aflibercept 2-mg (EYLEA) prefilled syringes versus vials from 2020 to 2022 (P < 0.0001).</p>","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tumor Localization with Indirect Ophthalmoscopy Transillumination.","authors":"Gabriela Mousse de Carvalho, João Victor Notini Arcanjo, Zelia Maria Corrêa","doi":"10.1016/j.oret.2025.02.008","DOIUrl":"https://doi.org/10.1016/j.oret.2025.02.008","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-Funduscopic Slit Lamp Assessment of the Posterior Hyaloid Membrane - A Simpler and More Effective Way of Clinically Diagnosing Posterior Vitreous Detachments.","authors":"Shefali Sood, Talha A Barra, Ryan T Duong, Imran A Khatri, Mohammed K Barazi, Michael H Osman, Abdullah Abou-Samra, Jeanette Du, Hamza A Lateef, J Mingyi Huang, Claudia G Hooten, Brian K Do, Joshua D Levinson, Alexander Melamud, Mariam Mathai, Mohsin H Ali","doi":"10.1016/j.oret.2025.02.027","DOIUrl":"https://doi.org/10.1016/j.oret.2025.02.027","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the clinical utility of a simpler method of detecting a complete posterior vitreous detachment (PVD) - visualization of the posterior hyaloid membrane at the slit lamp - which does not require expert dilated fundus examination skills, special instrumentation (fundoscopy lenses), or imaging devices (OCT or B-scan).</p><p><strong>Design: </strong>Cross-sectional case series PARTICIPANTS: All eligible patients presenting to the retina clinic during the study period were consecutively examined.</p><p><strong>Methods: </strong>All patients were examined for the presence or absence of a PVD using the posterior hyaloid membrane assessment method, Weiss ring assessment method, and via optical coherence tomography (OCT) performed by three masked graders.</p><p><strong>Main outcome measures: </strong>The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), receiver operator curves (ROC) and areas under the curve (AUC) were analyzed to assess the clinical utility of the two methods.</p><p><strong>Results: </strong>A total of 206 eyes of 118 patients were included. The incidence of true posterior vitreous detachments based on OCT was 57.3%. The posterior hyaloid assessment method was more sensitive than the Weiss ring assessment method (89.8% vs 79.7%, p-value: 0.04), and had a higher NPV (87.5% vs 78.2%, p-value: <0.01). There was no significant difference in specificity between the posterior hyaloid membrane and Weiss ring methods (95.5% vs 97.4%, p-value: 0.5) or PPV (96.4% vs 97.3%, p-value: 0.2). The AUC for the posterior hyaloid assessment and Weiss Ring methods were 0.93 and 0.89, respectively (chi-squared=2.84, p-value: 0.09).</p><p><strong>Conclusions: </strong>This study shows that this method of assessing the posterior hyaloid status is clinically meaningful and has a high sensitivity, specificity, positive predictive value, negative predictive value, and area under the curve. Compared to the Weiss ring method, the posterior hyaloid membrane assessment has a significantly higher sensitivity and negative predictive value and a similarly high specificity, positive predictive value, and area under the curve. Although trainees are not regularly taught this diagnostic skill, these results support that visualizing and assessing the posterior hyaloid membrane should be in every ophthalmologist's diagnostic skill repertoire.</p>","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wide-Field Imaging of a Large Retinal Cavernous Hemangioma in a 13-Year-Old Boy.","authors":"Antoine Arandilla, Elodie Bousquet, Paul Goupillou","doi":"10.1016/j.oret.2025.02.006","DOIUrl":"https://doi.org/10.1016/j.oret.2025.02.006","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral Choroidal Melanocytosis.","authors":"Sylvia Nghiem-Buffet, Salomon Y Cohen","doi":"10.1016/j.oret.2025.02.007","DOIUrl":"https://doi.org/10.1016/j.oret.2025.02.007","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}