Ophthalmology. Retina最新文献

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Time-Driven Activity-BasedCosting Analysis of Panretinal Photocoagulation 基于时间驱动作业的全视网膜光凝成本分析。
IF 4.4
Ophthalmology. Retina Pub Date : 2025-05-01 DOI: 10.1016/j.oret.2025.01.007
Sean T. Berkowitz MD, MBA , David L. Zhang MD , Warren W. Pan MD, PhD , Osama Ahmed MD , Cagri G. Besirli MD, PhD , Nicolaas P. DeRuyter MD , Tahreem A. Mir MD , Russel H. Dinh MD , Mark W. Johnson MD , Avni P. Finn MD, MBA
{"title":"Time-Driven Activity-BasedCosting Analysis of Panretinal Photocoagulation","authors":"Sean T. Berkowitz MD, MBA , David L. Zhang MD , Warren W. Pan MD, PhD , Osama Ahmed MD , Cagri G. Besirli MD, PhD , Nicolaas P. DeRuyter MD , Tahreem A. Mir MD , Russel H. Dinh MD , Mark W. Johnson MD , Avni P. Finn MD, MBA","doi":"10.1016/j.oret.2025.01.007","DOIUrl":"10.1016/j.oret.2025.01.007","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":"9 5","pages":"Pages 498-501"},"PeriodicalIF":4.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intraocular Melanocytoma in a 37-Year-Old Patient 一名 37 岁患者的眼内黑色素细胞瘤
IF 4.4
Ophthalmology. Retina Pub Date : 2025-05-01 DOI: 10.1016/j.oret.2024.09.013
Blanca Casado-Pelaez MD , Romana García-Gil MD , Rafael Martínez-Costa MD, PhD
{"title":"Intraocular Melanocytoma in a 37-Year-Old Patient","authors":"Blanca Casado-Pelaez MD , Romana García-Gil MD , Rafael Martínez-Costa MD, PhD","doi":"10.1016/j.oret.2024.09.013","DOIUrl":"10.1016/j.oret.2024.09.013","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":"9 5","pages":"Page e47"},"PeriodicalIF":4.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142546609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Choroidal Folds in Checkpoint Inhibitor-Induced Vogt-Koyanagi-Harada–Like Uveitis 检查点抑制剂诱发的Vogt-Koyanagi-Harada样葡萄膜炎的脉络膜皱褶
IF 4.4
Ophthalmology. Retina Pub Date : 2025-05-01 DOI: 10.1016/j.oret.2024.10.002
Pedro Carreira MD , Mariana Vaz MD , Diogo Cabral MD
{"title":"Choroidal Folds in Checkpoint Inhibitor-Induced Vogt-Koyanagi-Harada–Like Uveitis","authors":"Pedro Carreira MD , Mariana Vaz MD , Diogo Cabral MD","doi":"10.1016/j.oret.2024.10.002","DOIUrl":"10.1016/j.oret.2024.10.002","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":"9 5","pages":"Page e50"},"PeriodicalIF":4.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142583843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between Systemic Methotrexate Therapy and Proliferative Vitreoretinopathy 全身性甲氨蝶呤治疗与增殖性玻璃体视网膜病变之间的关系
IF 4.4
Ophthalmology. Retina Pub Date : 2025-05-01 DOI: 10.1016/j.oret.2024.10.023
Xinyi Chen MD , Jeremy D. Keenan MD, MPH , Jay M. Stewart MD
{"title":"Association between Systemic Methotrexate Therapy and Proliferative Vitreoretinopathy","authors":"Xinyi Chen MD ,&nbsp;Jeremy D. Keenan MD, MPH ,&nbsp;Jay M. Stewart MD","doi":"10.1016/j.oret.2024.10.023","DOIUrl":"10.1016/j.oret.2024.10.023","url":null,"abstract":"<div><h3>Objective</h3><div>Proliferative vitreoretinopathy (PVR) is a major cause for failure of retinal detachment (RD) repair. We sought to determine if patients taking systemic methotrexate (MTX) therapy had a lower incidence of PVR.</div></div><div><h3>Design</h3><div>Multicenter retrospective cohort study.</div></div><div><h3>Participants</h3><div>Patients aged ≥18 years who were documented in the Sight Outcomes Research Collaborative (SOURCE) repository to have received a diagnosis of RD and have undergone RD repair surgery between 2004 and 2024. We only included patients who had been in the SOURCE system for at least 6 months before the diagnosis date and had no prior record of RD repair surgery. We excluded patients with an unknown laterality of the primary RD repair, history of PVR, proliferative diabetic retinopathy, serous RD, retinal dialysis, or ocular trauma.</div></div><div><h3>Methods</h3><div>The exposure variable of interest was systemic MTX use, as documented from the medication list. The outcome of interest was the presence of new-onset PVR within 6 months of surgery. Incident PVR was modeled in log binomial regression models that included terms for systemic MTX use and method of primary RD repair. Regression models included inverse probability weights based on propensity scores for systemic MTX use. We conducted similar analyses for other antimetabolite agents (e.g., azathioprine and mycophenolate mofetil).</div></div><div><h3>Main Outcome Measures</h3><div>Cumulative incidence of PVR and adjusted risk ratio (RR) of developing PVR within 6 months of the initial RD.</div></div><div><h3>Results</h3><div>Of the 2674 eligible patients, 48 (1.8%) were taking systemic MTX at the time of RD repair. The 6-month cumulative incidence of PVR after the primary RD was 4.2% for patients taking systemic MTX compared with 9.2% for those not taking MTX (adjusted RR, 0.58; 95% confidence interval [CI], 0.47–0.71). Similar results were found for azathioprine (adjusted RR, 0.28; 95% CI, 0.22–0.37) but not mycophenolate mofetil (adjusted RR, 0.93; 95% CI, 0.77–1.11).</div></div><div><h3>Conclusions</h3><div>Patients taking systemic MTX or azathioprine were significantly less likely to develop PVR within 6 months of primary RD compared with those not taking MTX or azathioprine.</div></div><div><h3>Financial Disclosure(s)</h3><div>Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.</div></div>","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":"9 5","pages":"Pages 431-436"},"PeriodicalIF":4.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142591336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bilateral Anti-VEGF on Same-Day-Investigation on Safety in Retinopathy of Prematurity 同日双侧抗血管内皮生长因子--早产儿视网膜病变安全性调查(BASISROP)--一项多中心回顾性研究。
IF 4.4
Ophthalmology. Retina Pub Date : 2025-05-01 DOI: 10.1016/j.oret.2024.11.004
Anil Babanrao Gangwe MD , Anjali Agrawal MS , Subhadra Jalali MS , Alay Banker MS , Tapas Padhi MS , Parag Shah DO, DNB , Renu P. Rajan MD , Sucheta Kulkarni DO, DNB , Shilpi Shah MS , Rekha Singhal MS , Pranab Das MS , Ajay Kapoor MS , Anand Vinekar FRCS, PhD , Snehal Bavaskar MS, DNB , Vasumathy Vedantham MS , Gaurav Sanghi MS , Shashwat Bhattacharya MD , Ahan Banker MBBS , Anita Gaikwad MS , Shivani Shrivastava MS , Raj Vardhan Azad MD
{"title":"Bilateral Anti-VEGF on Same-Day-Investigation on Safety in Retinopathy of Prematurity","authors":"Anil Babanrao Gangwe MD ,&nbsp;Anjali Agrawal MS ,&nbsp;Subhadra Jalali MS ,&nbsp;Alay Banker MS ,&nbsp;Tapas Padhi MS ,&nbsp;Parag Shah DO, DNB ,&nbsp;Renu P. Rajan MD ,&nbsp;Sucheta Kulkarni DO, DNB ,&nbsp;Shilpi Shah MS ,&nbsp;Rekha Singhal MS ,&nbsp;Pranab Das MS ,&nbsp;Ajay Kapoor MS ,&nbsp;Anand Vinekar FRCS, PhD ,&nbsp;Snehal Bavaskar MS, DNB ,&nbsp;Vasumathy Vedantham MS ,&nbsp;Gaurav Sanghi MS ,&nbsp;Shashwat Bhattacharya MD ,&nbsp;Ahan Banker MBBS ,&nbsp;Anita Gaikwad MS ,&nbsp;Shivani Shrivastava MS ,&nbsp;Raj Vardhan Azad MD","doi":"10.1016/j.oret.2024.11.004","DOIUrl":"10.1016/j.oret.2024.11.004","url":null,"abstract":"<div><h3>Purpose</h3><div>To report an incidence of procedure-related complications in preterm infants with retinopathy of prematurity (ROP) treated with intravitreal anti-VEGFs injection in both eyes on the same day.</div></div><div><h3>Design</h3><div>Retrospective, multicenter case series.</div></div><div><h3>Subjects</h3><div>Preterm infants with ROP treated with anti-VEGF bilaterally on the same day.</div></div><div><h3>Methods</h3><div>All included infants underwent intravitreal anti-VEGF injection in both eyes under aseptic precautions in an ophthalmic operation theater (OT) or neonatal intensive care unit (NICU). A postoperative examination was performed to look for procedure-related complications.</div></div><div><h3>Main Outcome Measures</h3><div>Incidence of procedure-related complication (presumed endophthalmitis, intraocular inflammation, lens injury, vitreous hemorrhage, and retinal tear) in the study cohort. To study the association of indication, type of anti-VEGF, type of needle used, setting of procedure, site of injection (distance from limbus), and experience of the treating ophthalmologist with the complications.</div></div><div><h3>Results</h3><div>Nine thousand nine hundred and eighty-four eyes of 4992 infants were analyzed. The procedure was most commonly performed in ophthalmic OT (8258, 82.7%) using a 29G (4514, 45.2%) needle between 1 and 1.5 mm (9984, 100%) from limbus. Aggressive ROP was the most common indication for anti-VEGF use (4866, 48.7%), whereas Bevacizumab was the most commonly used anti-VEGF agent (8642, 86.6%). Overall, 26 eyes (0.3%) had procedure-related complications. Lens injury (15, 0.15%) and presumed endophthalmitis (7, 0.07%) were the most common complications. One eye had culture-proven endophthalmitis with <em>Pseudomonas aeruginosa</em>. No case of bilateral endophthalmitis was noted. Endophthalmitis was not associated with the setting of a procedure or type of anti-VEGF used, whereas the risk of lens injury was 7 times higher when performed in NICU and 30 times higher when performed by an ophthalmologist with &lt;1 year of experience in injecting anti-VEGF in preterm infants.</div></div><div><h3>Conclusions</h3><div>The incidence of presumed endophthalmitis after bilateral same-day anti-VEGF in infants with ROP is 0.07%. These infants can be treated in both eyes on the same day with the anti-VEGFs and needles (29–32G) evaluated in this study, with emphasis on the direction of needle parallel to the visual axis. Extra precaution is advocated if the procedure is planned in the NICU or by an ophthalmologist with limited experience.</div></div><div><h3>Financial Disclosure(s)</h3><div>The authors have no proprietary or commercial interest in any materials discussed in this article.</div></div>","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":"9 5","pages":"Pages 484-492"},"PeriodicalIF":4.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical and Histopathologic Findings in Jalili Syndrome 贾立综合征的临床和组织病理学发现。
IF 4.4
Ophthalmology. Retina Pub Date : 2025-05-01 DOI: 10.1016/j.oret.2024.11.002
Maria Franca MD, MSc , Joana Providência MD, MSc , Guilherme Castela MD, PhD , Daniela Patrício MSc , Inês Santos Sousa MSc , António Francisco Ambrósio PhD , Celso Henrique Alves PhD , João Pedro Marques MD, PhD
{"title":"Clinical and Histopathologic Findings in Jalili Syndrome","authors":"Maria Franca MD, MSc ,&nbsp;Joana Providência MD, MSc ,&nbsp;Guilherme Castela MD, PhD ,&nbsp;Daniela Patrício MSc ,&nbsp;Inês Santos Sousa MSc ,&nbsp;António Francisco Ambrósio PhD ,&nbsp;Celso Henrique Alves PhD ,&nbsp;João Pedro Marques MD, PhD","doi":"10.1016/j.oret.2024.11.002","DOIUrl":"10.1016/j.oret.2024.11.002","url":null,"abstract":"<div><h3>Purpose</h3><div>To correlate histopathologic findings in an eye with Jalili syndrome with clinical and imaging results available before enucleation.</div></div><div><h3>Design</h3><div>Case report with histopathologic analysis.</div></div><div><h3>Subjects</h3><div>Histopathologic analysis of an enucleated eye from a 63-year-old woman diagnosed with Jalili syndrome.</div></div><div><h3>Methods</h3><div>Age at diagnosis, symptoms, personal and family history, and genetic testing results and previous retinal imaging were retrieved from the patient file. The ocular specimen was dissected, retinal sections were prepared, and analysis with hematoxylin and eosin staining and fluorescent immunohistochemistry was performed. The histopathologic findings were compared with the patient’s imaging results available before enucleation.</div></div><div><h3>Results</h3><div>The ocular specimen analyzed belonged to a 63-year-old woman with Jalili syndrome, homozygous for the likely pathogenic c.971T&gt;C p.(Leu324Pro) variant in the <em>CNNM4</em> gene (NM_020184.3). This patient had no light perception bilaterally and suffered from bilateral, painful, severe dry eye, with refractory to conservative treatment for 7 years before enucleation. At 1-month follow-up after enucleation and orbital implant placement, the socket was fully recovered, and a custom ocular prosthesis was adapted. The patient experienced total pain relief, improved quality of life, and a good cosmetic result. The histopathologic analyses revealed loss of photoreceptor cells, accumulation of autofluorescent material in the subretinal space, partial preservation of the inner retinal lamination, Müller glial cell disorganization, and increased number of microglial cells in the nuclear layers.</div></div><div><h3>Conclusions</h3><div>Our findings highlight the severe nature of this inherited retinal degenerative disease with significant damage to the outer retinal layers, absence of synaptic terminals, and loss of photoreceptors, indicating an advanced disease stage. The presence of microglial cells in the remaining nuclear layers suggests a role in photoreceptor degeneration. This study represents the first comprehensive description of clinical, genetic, imaging, and histopathologic findings in Jalili syndrome.</div></div><div><h3>Financial Disclosure(s)</h3><div>The authors have no proprietary or commercial interest in any materials discussed in this article.</div></div>","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":"9 5","pages":"Pages 476-483"},"PeriodicalIF":4.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bilateral Exudative Retinal Detachments due to Primary Hyperoxaluria in a Child 儿童原发性高草酸尿症导致的双侧渗出性视网膜脱离
IF 4.4
Ophthalmology. Retina Pub Date : 2025-05-01 DOI: 10.1016/j.oret.2024.09.012
Blanca Casado-Pelaez MD , Sara Khanji Fustek MD , Honorio Barranco Gonzalez MD
{"title":"Bilateral Exudative Retinal Detachments due to Primary Hyperoxaluria in a Child","authors":"Blanca Casado-Pelaez MD ,&nbsp;Sara Khanji Fustek MD ,&nbsp;Honorio Barranco Gonzalez MD","doi":"10.1016/j.oret.2024.09.012","DOIUrl":"10.1016/j.oret.2024.09.012","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":"9 5","pages":"Page e46"},"PeriodicalIF":4.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142583834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Myopic Tractional Maculopathy and Retinoschisis with Telangiectasia 近视牵引性黄斑病变和视网膜裂孔伴远端血管扩张症。
IF 4.4
Ophthalmology. Retina Pub Date : 2025-05-01 DOI: 10.1016/j.oret.2024.09.015
Livia Faes MD , K. Bailey Freund MD
{"title":"Myopic Tractional Maculopathy and Retinoschisis with Telangiectasia","authors":"Livia Faes MD ,&nbsp;K. Bailey Freund MD","doi":"10.1016/j.oret.2024.09.015","DOIUrl":"10.1016/j.oret.2024.09.015","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":"9 5","pages":"Page e49"},"PeriodicalIF":4.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142583858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Evaluation of a Novel CRISPR-Cas12a-Based RID-MyC Assay for the Diagnosis of Fungal Endophthalmitis 基于 CRISPR-Cas12a 的新型 RID-MyC 检测法用于眼底真菌病诊断的临床评估。
IF 4.4
Ophthalmology. Retina Pub Date : 2025-05-01 DOI: 10.1016/j.oret.2024.11.003
Hanith Raj Deivarajan MSc , Prabhakara Sethupathy R MSc , Vignesh Elamurugan MBBS , Akshayaa VS MSc , Reega P MSc , Dharani Chelliah MSc , Hari Vignesh S MSc , Elakkiya Nandhini GR MSc , Kanmani M MSc , Dharsini Nandhakumar BE , Karvannan Sevugamurthi MSc , Saravanan VR MBBS, DNB , Anuradha K MBBS, FRCS , Parag K. Shah MBBS, DNB , Ram Rammohan PhD , Abhishek Nair MBBS , Krutin Shah MBBS , Anju Jose MBBS, DNB , Jaishree Pandian PhD , Lalitha Prajna MBBS , Siddharth Narendran MBBS
{"title":"Clinical Evaluation of a Novel CRISPR-Cas12a-Based RID-MyC Assay for the Diagnosis of Fungal Endophthalmitis","authors":"Hanith Raj Deivarajan MSc ,&nbsp;Prabhakara Sethupathy R MSc ,&nbsp;Vignesh Elamurugan MBBS ,&nbsp;Akshayaa VS MSc ,&nbsp;Reega P MSc ,&nbsp;Dharani Chelliah MSc ,&nbsp;Hari Vignesh S MSc ,&nbsp;Elakkiya Nandhini GR MSc ,&nbsp;Kanmani M MSc ,&nbsp;Dharsini Nandhakumar BE ,&nbsp;Karvannan Sevugamurthi MSc ,&nbsp;Saravanan VR MBBS, DNB ,&nbsp;Anuradha K MBBS, FRCS ,&nbsp;Parag K. Shah MBBS, DNB ,&nbsp;Ram Rammohan PhD ,&nbsp;Abhishek Nair MBBS ,&nbsp;Krutin Shah MBBS ,&nbsp;Anju Jose MBBS, DNB ,&nbsp;Jaishree Pandian PhD ,&nbsp;Lalitha Prajna MBBS ,&nbsp;Siddharth Narendran MBBS","doi":"10.1016/j.oret.2024.11.003","DOIUrl":"10.1016/j.oret.2024.11.003","url":null,"abstract":"<div><h3>Objective</h3><div>This study evaluated the RID-MyC (Rapid Identification of Mycoses using clustered regularly interspaced short palindromic repeats [CRISPR]) assay, a CRISPR/Cas12a-based diagnostic tool, for its efficacy in diagnosing fungal endophthalmitis (FE) compared with panfungal polymerase chain reaction (PCR) and culture methods.</div></div><div><h3>Design</h3><div>A comparative cross-sectional study assessing the performance of the RID-MyC assay against established diagnostic modalities for FE.</div></div><div><h3>Subjects</h3><div>The study included 133 intraocular samples from 117 patients with suspected microbial endophthalmitis.</div></div><div><h3>Methods</h3><div>The study compared the sensitivity, specificity, positive predictive value, and negative predictive value of the RID-MyC assay against panfungal PCR and culture. The limit of detection for <em>Aspergillus flavus</em> and <em>Candida albicans</em> was determined for both RID-MyC and panfungal PCR across 3 different media: nuclease-free water, aqueous humor, and vitreous humor. Discrepancy analysis was conducted for discordant results, incorporating clinical outcomes and responses to antifungal treatment.</div></div><div><h3>Main Outcome Measures</h3><div>The study primarily assessed the sensitivity, specificity, positive predictive value, and negative predictive value for clinical samples. Time to diagnosis was also evaluated.</div></div><div><h3>Results</h3><div>The RID-MyC assay demonstrated a sensitivity of 88.24% (95% confidence interval [CI], 63.56%–98.54%) and specificity of 93.1% (95% CI, 86.86%–96.98%), with positive predictive value and negative predictive value of 65.22% (95% CI, 48.45%–78.91%) and 98.18% (95% CI, 93.62%–99.50%), respectively. Discrepancy analysis enhanced sensitivity to 90.48% (95% CI, 69.62%–98.83%) and specificity to 96.43% (95% CI, 91.11%–99.02%). The RID-MyC assay was 10- to 1000-fold more sensitive than panfungal PCR in detecting <em>A. flavus</em> and <em>C. albicans</em> in intraocular specimens. The time to diagnosis with the RID-MyC assay was consistently &lt;2 hours.</div></div><div><h3>Conclusions</h3><div>The RID-MyC assay may advance the rapid and precise diagnosis of FE, with possible relevance to other invasive fungal conditions.</div></div><div><h3>Financial Disclosure(s)</h3><div>Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.</div></div>","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":"9 5","pages":"Pages 444-452"},"PeriodicalIF":4.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing Macular Function: Should We Move Beyond Pragmatic Measures of Visual Acuity? 评估黄斑功能:我们是否应该超越实用的视力测量?
IF 4.4
Ophthalmology. Retina Pub Date : 2025-05-01 DOI: 10.1016/j.oret.2025.01.006
Marion R. Munk MD, PhD, Eleonora M. Lad MD, PhD, Usha Chakravarthy MD, PhD
{"title":"Assessing Macular Function: Should We Move Beyond Pragmatic Measures of Visual Acuity?","authors":"Marion R. Munk MD, PhD,&nbsp;Eleonora M. Lad MD, PhD,&nbsp;Usha Chakravarthy MD, PhD","doi":"10.1016/j.oret.2025.01.006","DOIUrl":"10.1016/j.oret.2025.01.006","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":"9 5","pages":"Pages 409-411"},"PeriodicalIF":4.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143888258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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