Ophthalmology. Retina最新文献

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SPONTANEOUS SOFT DRUSEN REGRESSION WITHOUT ATROPHY AND THE DRUSEN OOZE.
IF 4.4
Ophthalmology. Retina Pub Date : 2025-02-28 DOI: 10.1016/j.oret.2025.02.023
Jordi Monés, Fernando Pagani, Juan Francisco Santamaria, Miriam Garcia, Cristina Romero, Daniel Garcia, Anna Serrano, Alicia Carrasco
{"title":"SPONTANEOUS SOFT DRUSEN REGRESSION WITHOUT ATROPHY AND THE DRUSEN OOZE.","authors":"Jordi Monés, Fernando Pagani, Juan Francisco Santamaria, Miriam Garcia, Cristina Romero, Daniel Garcia, Anna Serrano, Alicia Carrasco","doi":"10.1016/j.oret.2025.02.023","DOIUrl":"https://doi.org/10.1016/j.oret.2025.02.023","url":null,"abstract":"<p><strong>Objective or purpose: </strong>To determine the incidence of spontaneous soft drusen regression without atrophy (DRwoA) in patients with intermediate or atrophic age-related macular degeneration (iAMD, aAMD) and evaluate associated events and offer potential explanations.</p><p><strong>Design: </strong>A retrospective review of the imaging of a consecutive series of 640 eyes from 320 patients with AMD who had at least 2 years of follow-up.</p><p><strong>Subjects: </strong>427 eyes from 262 patients with iAMD or aAMD and no present or past exudative AMD.</p><p><strong>Methods: </strong>Retinal imaging included infrared reflectance imaging (IR), fundus autofluorescence (FAF), spectral-domain OCT (SD-OCT), and color fundus photography (CFP).</p><p><strong>Main outcome measures: </strong>Drusen regression without atrophy (DRwoA) with integrity of the retinal pigment epithelium (RPE) and repositioning over Bruch's membrane. Additionally, drusen that would collapse with atrophy (DCwA) in the same area simultaneously were named \"sentinel\" DCwA. The reversibility of features of incomplete retinal pigment epithelium and outer retinal atrophy (iRORA), as well as areas (\"halos\") of DRwoA around the \"sentinel\" drusen.</p><p><strong>Results: </strong>Among the 427 eyes, 53 events of DRwoA were found, representing 24,17% of the eyes with soft drusen. In 50 cases (94,33%), a \"sentinel\" DCwA in the vicinity was found. In 58% of the cases, a well-identifiable halo of drusen disappearance around the \"sentinel\" DCwA was well visible.</p><p><strong>Conclusions: </strong>DRwoA is a frequently observed phenomenon linked to soft drusen and almost invariably occurs near a \"sentinel\" DCwA. The coalescence of the drusen and the spatial and temporal association of the DRwaA and the DCwA strongly suggest that the drusen material of DRwoA escapes to a contiguous \"sentinel\" DCwA. While the hypothesis of the disappearance of drusen material due to RPE death may explain the DCwA, it fails to account for DRwoA. Instead, the \"drusen ooze\" hypothesis, which posits the movement of drusen content to the subretinal space through RPE defects, may explain both the DCwA and the DRwoA. This hypothesis offers insights into the reversibility of iRORA features and suggests that therapies targeting drusen material removal before RPE disruptions could potentially prevent atrophy secondary to soft drusen collapse.</p>","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between Age-related Macular Degeneration and mortality in a high cardiovascular risk cohort: A prospective cohort study.
IF 4.4
Ophthalmology. Retina Pub Date : 2025-02-28 DOI: 10.1016/j.oret.2025.02.024
Richard Kha, George Burlutsky, Aravinda Thiagalingam, Pramesh Kovoor, Joseph Chiha, Paul Mitchell, Gerald Liew
{"title":"Association between Age-related Macular Degeneration and mortality in a high cardiovascular risk cohort: A prospective cohort study.","authors":"Richard Kha, George Burlutsky, Aravinda Thiagalingam, Pramesh Kovoor, Joseph Chiha, Paul Mitchell, Gerald Liew","doi":"10.1016/j.oret.2025.02.024","DOIUrl":"https://doi.org/10.1016/j.oret.2025.02.024","url":null,"abstract":"<p><strong>Objective: </strong>-To investigate if age-related macular degeneration (AMD) predicts risk of all-cause and cardiovascular disease (CVD) mortality in a high CVD risk cohort.</p><p><strong>Design: </strong>- Prospective cohort study PARTICIPANTS: - 1545 adult participants who presented to a tertiary Australian hospital for evaluation of acute coronary syndrome were included in this study.</p><p><strong>Methods: </strong>- Participants were evaluated for acute coronary syndrome using coronary angiography. Participants were concurrently examined for AMD from mydriatic fundus photographs which were graded using the Wisconsin grading system into categories of any AMD, early AMD and late AMD. Coronary artery disease (CAD) was graded from coronary angiograms using the Gensini score. Mortality data were obtained 9 years after baseline examination through data linkage with the Australian National Death Index. Hazard ratios (HR) were obtained using Cox regression analysis.</p><p><strong>Main outcome measures: </strong>All-cause and CVD mortality data were obtained through data linkage with the Australian National Death Index. Death rates through June 2018 were compared by demographics and potential confounders.</p><p><strong>Results: </strong>- Any AMD was identified in 107 (6.9%) participants, including those with early (n=86) and late AMD (n=21). Over 9 years of follow-up, 234 (15.1%) participants had died, including 174 (11.3%) participants from fatal CVD events. After controlling for age, sex, body mass index , total cholesterol, smoking status, history of diabetes, hypertension, myocardial infarction, stroke and macrovascular CAD severity using the Gensini score, there was an increased rate of all-cause mortality for those with any AMD (hazard ratio [HR] 2.37, [95% CI: 1.54-3.64]), early AMD (HR 2.42 [1.48-3.94]) and late AMD (HR 2.25 [1.08-4.71]). Any AMD (HR 2.62, [1.61-4.26]) and early AMD (HR 2.61 [1.50-4.64]) were also associated with a greater likelihood of CVD mortality. Late AMD was not associated with CVD mortality.</p><p><strong>Conclusions: </strong>- In individuals with high CVD risk, presence of AMD at any stage independently predicted increased all-cause mortality. Meanwhile, any and early AMD increased risk of CVD mortality. Although mechanisms are unclear, this potentially reflects shared pathways between AMD and CVD.</p>","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rhegmatogenous Retinal Detachment Hiding an Underlying Choroidal Melanoma.
IF 4.4
Ophthalmology. Retina Pub Date : 2025-02-28 DOI: 10.1016/j.oret.2025.01.018
Gabrielle E Kozlowski, Hidayet Sener, Carol L Shields
{"title":"Rhegmatogenous Retinal Detachment Hiding an Underlying Choroidal Melanoma.","authors":"Gabrielle E Kozlowski, Hidayet Sener, Carol L Shields","doi":"10.1016/j.oret.2025.01.018","DOIUrl":"https://doi.org/10.1016/j.oret.2025.01.018","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vessels Spanning Avascular Retina in Familial Exudative Vitreoretinopathy.
IF 4.4
Ophthalmology. Retina Pub Date : 2025-02-28 DOI: 10.1016/j.oret.2025.02.022
D Wade Redick, Joshua M Barnett, G Baker Hubbard
{"title":"Vessels Spanning Avascular Retina in Familial Exudative Vitreoretinopathy.","authors":"D Wade Redick, Joshua M Barnett, G Baker Hubbard","doi":"10.1016/j.oret.2025.02.022","DOIUrl":"https://doi.org/10.1016/j.oret.2025.02.022","url":null,"abstract":"<p><p>The authors describe a fluorescein angiography finding of thick bridging vessels spanning peripheral avascular retina (BVSPAR) in 7.8% of eyes with FEVR. BVSPAR may be associated with poor outcomes and worsening traction after treatment.</p>","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Macular Atrophy-Related Observations in Eyes Treated with the Port Delivery System with Ranibizumab in the Archway Trial.
IF 4.4
Ophthalmology. Retina Pub Date : 2025-02-25 DOI: 10.1016/j.oret.2025.02.017
Glenn J Jaffe, Briana Cameron, Giulio Barteselli, Natalia Callaway, Cindy Skalak, John Choong, Shamika Gune
{"title":"Macular Atrophy-Related Observations in Eyes Treated with the Port Delivery System with Ranibizumab in the Archway Trial.","authors":"Glenn J Jaffe, Briana Cameron, Giulio Barteselli, Natalia Callaway, Cindy Skalak, John Choong, Shamika Gune","doi":"10.1016/j.oret.2025.02.017","DOIUrl":"https://doi.org/10.1016/j.oret.2025.02.017","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the development of macular atrophy (MA) in eyes treated with the Port Delivery System with ranibizumab (PDS) with those treated with monthly intravitreal ranibizumab injections in the Archway trial.</p><p><strong>Design: </strong>Preplanned exploratory analysis of a phase 3, open-label, randomized trial.</p><p><strong>Participants: </strong>Patients with neovascular age-related macular degeneration (nAMD) diagnosed within 9 months of screening, previously treated with and responsive to anti-vascular endothelial growth factor therapy.</p><p><strong>Methods: </strong>Eyes were randomized 3:2 to treatment with the PDS 100 mg/mL with fixed 24-week (Q24W) refill-exchanges (PDS Q24W) or intravitreal ranibizumab 0.5 mg injections every 4 weeks (monthly ranibizumab).</p><p><strong>Main outcome measures: </strong>Prevalence, incidence, and progression of MA.</p><p><strong>Results: </strong>The analysis population consisted of 415 eyes (248 and 167 eyes in the PDS Q24W and monthly ranibizumab arms, respectively). At study baseline, MA was observed in 22.3% (PDS Q24W) and 20.4% (monthly ranibizumab) of eyes. At week 96, prevalence of MA was 39.1% and 39.2% while incidence of new MA in eyes without MA at baseline was 20.0% and 22.6% in the PDS Q24W and monthly ranibizumab arms, respectively. In eyes without baseline MA, mean MA area at week 96 was 0.4 in the PDS Q24W arm and 3.8 mm<sup>2</sup> in the monthly ranibizumab arm with a difference of 3.4mm<sup>2</sup>, (P = 0.054) favoring PDS. In eyes with baseline MA, mean change in MA area from baseline to week 96 was +2.2 mm<sup>2</sup> for both the PDS Q24W and monthly ranibizumab arms.</p><p><strong>Conclusions: </strong>In the Archway trial, which compared PDS Q24W with monthly ranibizumab injections for nAMD treatment over 2 years, prevalence and incidence of MA were similar between arms over the study duration. In eyes without baseline MA, PDS-treated eyes had less MA area by 3.4 mm<sup>2</sup>, a potentially clinically meaningful (although not statistically significant) difference. The results of this prespecified exploratory analysis suggest that PDS treatment is not associated with higher incidence or progression of MA when compared with monthly injections of ranibizumab. In eyes without baseline MA, the progression of atrophy area was 4 times less in PDS-treated eyes. Additional studies could further elucidate this observation.</p>","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143524066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fluorescein Angiography May Predict Surgical Outcomes of Tractional Retinal Detachment in Familial Exudative Vitreoretinopathy.
IF 4.4
Ophthalmology. Retina Pub Date : 2025-02-25 DOI: 10.1016/j.oret.2025.02.018
Tomoyuki Oga, Fukutaro Mano, Kazuki Kuniyoshi, Chiharu Iwahashi, Hiroyuki Kondo, Shunji Kusaka
{"title":"Fluorescein Angiography May Predict Surgical Outcomes of Tractional Retinal Detachment in Familial Exudative Vitreoretinopathy.","authors":"Tomoyuki Oga, Fukutaro Mano, Kazuki Kuniyoshi, Chiharu Iwahashi, Hiroyuki Kondo, Shunji Kusaka","doi":"10.1016/j.oret.2025.02.018","DOIUrl":"10.1016/j.oret.2025.02.018","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate factors associated with the surgical outcomes of tractional retinal detachment (TRD) in eyes with familial exudative vitreoretinopathy (FEVR).</p><p><strong>Design: </strong>Retrospective chart review.</p><p><strong>Subjects: </strong>Patients who underwent surgeries for TRD associated with FEVR between April 2011 and April 2022 and had a follow-up of ≥18 months were included in the analysis.</p><p><strong>Methods: </strong>Vitrectomy was performed on 47 eyes, with scleral buckling in 4 eyes and simultaneous lensectomy in 26 eyes.</p><p><strong>Main outcome measures: </strong>Data, including sex, age at the first surgery, disease stage, extent of fibrovascular proliferation (FVP, within 3 hours or >3 hours), preoperative fluorescein angiography (FA) grading (grade 1: mild leakage caused by FVP, grade 2: severe leakage), surgical outcomes, and complications, were collected.</p><p><strong>Results: </strong>The age at the initial surgery ranged from 1 month to 15 years (median: 6 months). Thirty-two eyes were from male patients, and 15 eyes were from female ones. Only 1 eye in 25 patients was affected. In 11 patients, bilateral eyes were involved. In total, 8 eyes presented with stage 3 FEVR, 31 with stage 4, and 8 with stage 5. The preoperative FA was performed on 38 of 47 eyes. There were 26 eyes with FA grade 1 and 12 eyes with FA grade 2. The retina was reattached in 33 (70.2%) eyes at the final examination. Based on the univariate logistic regression analysis, a higher retinal reattachment (RA) rate was significantly associated with a lower FEVR stage (P = 0.0001), FA grade (P = 0.0008), and preoperative extent of FVP (P = 0.02). In the multivariate logistic regression analysis, only FA grade was significantly associated with RA (P = 0.04, odds ratio: 9.0, 95% confidence interval: 1.2-7.0 × 10).</p><p><strong>Conclusion: </strong>Eyes with TRD associated with FEVR in patients with mild FA leakage had a higher RA rate. Hence, the use of FA in evaluating disease activity can be useful in predicting surgical outcomes.</p><p><strong>Financial disclosure(s): </strong>Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.</p>","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multimodal Imaging Analysis of Supra-retinal Pigment Epithelium Granular Deposits in Treatment-Naive Full-Thickness Macular Holes.
IF 4.4
Ophthalmology. Retina Pub Date : 2025-02-24 DOI: 10.1016/j.oret.2025.02.016
Daniela Bacherini, Stefano Mercuri, Andrea Govetto, Laura Di Leo, Tomaso Caporossi, Francesco Faraldi, Stanislao Rizzo, Gianni Virgili, Fabrizio Giansanti
{"title":"Multimodal Imaging Analysis of Supra-retinal Pigment Epithelium Granular Deposits in Treatment-Naive Full-Thickness Macular Holes.","authors":"Daniela Bacherini, Stefano Mercuri, Andrea Govetto, Laura Di Leo, Tomaso Caporossi, Francesco Faraldi, Stanislao Rizzo, Gianni Virgili, Fabrizio Giansanti","doi":"10.1016/j.oret.2025.02.016","DOIUrl":"10.1016/j.oret.2025.02.016","url":null,"abstract":"<p><strong>Purpose: </strong>To describe the morphology and provide anatomical correlations of supra-retinal pigment epithelium (RPE) granular deposits in full-thickness macular holes (FTMHs).</p><p><strong>Design: </strong>Retrospective, observational, single-center study.</p><p><strong>Participants: </strong>Patients with idiopathic FTMH presenting to the University of Florence Eye clinic.</p><p><strong>Methods: </strong>Thirty-six eyes of 34 patients with a diagnosis of treatment-naive FTMH, scheduled for surgery, underwent multimodal imaging including spectral-domain OCT (SD-OCT), en-face OCT, and adaptive optics ophthalmoscopy (AOO). Different methodologies were evaluated to determine the location and topographical correspondence of granulations. The total volume of supra-RPE granular deposits was correlated to the macular hole (MH) characteristics and SD-OCT markers of photoreceptor damage with Spearman correlation coefficient (CC).</p><p><strong>Main outcome measures: </strong>Morphological correlations in FTMHs using SD-OCT and AOO.</p><p><strong>Results: </strong>Using AOO, supra-RPE granular deposits appeared as hyper-reflective structures, mostly found within the minimum linear diameter (MLD) (104 of 139 deposits, 74%). Different imaging techniques were equally effective in the topographical identification of supra-RPE granular deposits (P > 0.30). The total volume of supra-RPE granular deposits significantly increased with stages B and C of FTMH, inversely correlated to the corrected ellipsoid zone (EZ) reflectivity (CC = -0.62) and positively correlated to the length of the EZ defect (CC = +0.41) and MH diameter at the base (CC = +0.35) and MLD (CC = +0.42) (all P < 0.05).</p><p><strong>Conclusions: </strong>Supra-RPE granular deposits can be identified accurately using AOO and en-face OCT. Characteristics using AOO and anatomical correlations at SD-OCT indicate supra-RPE granular deposits as signs of photoreceptor degeneration.</p><p><strong>Financial disclosure(s): </strong>The authors have no proprietary or commercial interest in any materials discussed in this article.</p>","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Longitudinal Progression of Myopic Maculopathy in a Long-Term Follow-Up of a European Cohort: Imaging Features and Visual Outcomes.
IF 4.4
Ophthalmology. Retina Pub Date : 2025-02-24 DOI: 10.1016/j.oret.2025.02.015
Matteo Mario Carlà, Francesco Boselli, Federico Giannuzzi, Emanuele Crincoli, Fiammetta Catania, Tomaso Caporossi, Stanislao Rizzo, Carlos Mateo
{"title":"Longitudinal Progression of Myopic Maculopathy in a Long-Term Follow-Up of a European Cohort: Imaging Features and Visual Outcomes.","authors":"Matteo Mario Carlà, Francesco Boselli, Federico Giannuzzi, Emanuele Crincoli, Fiammetta Catania, Tomaso Caporossi, Stanislao Rizzo, Carlos Mateo","doi":"10.1016/j.oret.2025.02.015","DOIUrl":"10.1016/j.oret.2025.02.015","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the longitudinal progression of myopic maculopathy in a European cohort of highly myopic patients, analyzing the disease natural history and its impact on visual function.</p><p><strong>Design: </strong>Retrospective, observational monocentric cohort study.</p><p><strong>Participants: </strong>The study included 1228 eyes from 781 highly myopic patients with a minimum follow-up time of 5 years. We collected best-corrected visual acuity (BCVA) measurement, axial length (AXL), fundus photography, and spectral-domain OCT, along with data regarding intraocular pressure-lowering drugs and glaucoma surgery.</p><p><strong>Methods: </strong>Myopic atrophic maculopathy (MAM) was graded according to the ATN classification system. The presence of myopic staphyloma followed Curtin's classification. The development of myopic neovascular maculopathy (MNM) and myopic tractional maculopathy (MTM) was also assessed, along with the presence of dome-shaped macula (DSM) and lacquer cracks (LCs) at baseline.</p><p><strong>Main outcome measures: </strong>The rate of MAM progression and visual outcomes. The secondary outcome included the correlation with the presence of staphyloma subtypes and the development of MNM and MTM.</p><p><strong>Results: </strong>The mean AXL was 31.6 ± 2.8 mm. Myopic atrophic maculopathy progressed in 57% of eyes over a mean follow-up of 11.4 years. Eyes with patchy atrophy progressed in 81% of cases, and 47% of them developed macular atrophy, whereas eyes with tessellated fundus progressed in only 19% of cases. The presence of a macular-involving staphyloma was associated with progression, particularly for type IX (86% rate of progression). A significant decline in BCVA (≥2 lines) was observed in 35.8% of eyes and correlated with AXL, glaucoma surgery, patchy atrophy, MNM, and MTM development (all P < 0.05). Active MNM developed in 190 eyes (15%), significantly associated with baseline LCs (odds ratio [OR], 2.56) and DSM (OR, 4.95), determined faster progression toward macular atrophy (OR, 5.91). Myopic tractional maculopathy complications were observed in 314 eyes (26%) and significantly correlated with the presence of a type I and II staphyloma.</p><p><strong>Conclusions: </strong>More than half of eyes with myopic maculopathy tended to progress, in particular in cases with patchy atrophy at baseline and in eyes developing MNM or MTM, which caused worse vision loss during the study period. Although DSM and LCs correlated with neovascular complications, the shape of the posterior staphyloma correlated with tractional complications.</p><p><strong>Financial disclosure(s): </strong>The authors have no proprietary or commercial interest in any materials discussed in this article.</p>","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spontaneous Remodeling of Abnormal Choroidal Vasculature.
IF 4.4
Ophthalmology. Retina Pub Date : 2025-02-21 DOI: 10.1016/j.oret.2025.01.003
Eliza Anthony, Jefila Jayakumar, Prabu Baskaran
{"title":"Spontaneous Remodeling of Abnormal Choroidal Vasculature.","authors":"Eliza Anthony, Jefila Jayakumar, Prabu Baskaran","doi":"10.1016/j.oret.2025.01.003","DOIUrl":"https://doi.org/10.1016/j.oret.2025.01.003","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply.
IF 4.4
Ophthalmology. Retina Pub Date : 2025-02-20 DOI: 10.1016/j.oret.2025.01.014
Cindy X Cai, Akihiko Nishimura, George Hripcsak
{"title":"Reply.","authors":"Cindy X Cai, Akihiko Nishimura, George Hripcsak","doi":"10.1016/j.oret.2025.01.014","DOIUrl":"https://doi.org/10.1016/j.oret.2025.01.014","url":null,"abstract":"","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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