Journal of Integrative Plant Biology最新文献

A group of TCP transcription factors is a missing link in strigolactone signaling. 一组TCP转录因子是独角甾内酯信号传导的缺失环节。

IF 9.3 1区生物学

Journal of Integrative Plant Biology Pub Date : 2026-05-07 DOI: 10.1111/jipb.70281

Yi Huang, Lumei Bi, Yongshuang Huang, Jinlan Liu, Lin Wang, Fang Qiu, Yuehua Wang, Li Chen, Meng Zhang, Ruifeng Yao

{"title":"A group of TCP transcription factors is a missing link in strigolactone signaling.","authors":"Yi Huang, Lumei Bi, Yongshuang Huang, Jinlan Liu, Lin Wang, Fang Qiu, Yuehua Wang, Li Chen, Meng Zhang, Ruifeng Yao","doi":"10.1111/jipb.70281","DOIUrl":"https://doi.org/10.1111/jipb.70281","url":null,"abstract":"Strigolactones (SLs) are plant-specialized butenolide signaling molecules, recognized as endogenous plant hormones, that control plant development and environmental adaptation. In Arabidopsis (Arabidopsis thaliana), the repressor D53-like SMXLs regulate the expression of a vast number of genes in an EAR-motif-dependent manner to mediate SL signaling. However, it remains unclear how the SMXLs are recruited to specific genes and implement unique functions in vivo. Based on chromatin co-distribution analysis, we constructed a chromatin co-localization map of SMXL6 with 108 transcription factors. Among the candidate transcription factors, the Class II TEOSINTE BRANCHED1/CYCLOIDEA/PCF (TCP) family member TCP4 shows the highest frequency of chromatin co-localization with SMXL6. SMXL6 and TCP4 co‑localize at the promoter regions of 18 SL-induced SMXL6 target genes (SISGs), including BRC1. We confirmed that TCP4 interacts with SMXL6 and can bind directly to these co‑localized sites. The loss of CIN-TCPs function reduces the hormone responsiveness of the SL-induced genes. Introducing the tcp3/4/10 into SL‑deficient mutants restored the BRC1 expression to a level exceeding that of the wild type. However, the branching phenotype of the SL‑deficient mutant was only partially rescued, suggesting a limited role for BRC1 in SL‑mediated branching control and implicating the involvement of additional factors. An unexpected finding was that tcp3/4/10 rescued the dwarf phenotype of the SL‑deficient mutants, providing an opportunity to elucidate the mechanisms underlying SL‑regulated plant height. These findings demonstrate that TCP4 mediates SMXL6 chromatin recruitment during SL signaling, and provide a new understanding of how SMXL6 participates in SL signaling-mediated gene expression and plant development.","PeriodicalId":195,"journal":{"name":"Journal of Integrative Plant Biology","volume":" ","pages":""},"PeriodicalIF":9.3,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disabling a conserved module confers broad-spectrum resistance. 禁用保守模块会带来广谱电阻。

IF 9.3 1区生物学

Journal of Integrative Plant Biology Pub Date : 2026-05-07 DOI: 10.1111/jipb.70286

Zhen Zeng, Yachun Su, Hui Ling, Youxiong Que

引用次数: 0

Arabidopsis inositol polyphosphate kinase activities regulate COP9 deneddylation functions in phosphate homeostasis. 拟南芥肌醇多磷酸激酶活性调节COP9在磷酸盐稳态中的脱羧功能。

IF 9.3 1区生物学

Journal of Integrative Plant Biology Pub Date : 2026-05-05 DOI: 10.1111/jipb.70268

Yashika Walia, Medha Noopur, Ishana Bhattacharya, Bhaskar Chandra Sahoo, Mritunjay Kasera, Naga Jyothi Pullagurla, Smritikana Dutta, Guizhen Liu, Gabriel Schaaf, Henning Jessen, Debabrata Laha, Souvik Bhattacharjee, Saikat Bhattacharjee

{"title":"Arabidopsis inositol polyphosphate kinase activities regulate COP9 deneddylation functions in phosphate homeostasis.","authors":"Yashika Walia, Medha Noopur, Ishana Bhattacharya, Bhaskar Chandra Sahoo, Mritunjay Kasera, Naga Jyothi Pullagurla, Smritikana Dutta, Guizhen Liu, Gabriel Schaaf, Henning Jessen, Debabrata Laha, Souvik Bhattacharjee, Saikat Bhattacharjee","doi":"10.1111/jipb.70268","DOIUrl":"https://doi.org/10.1111/jipb.70268","url":null,"abstract":"Plant Cullin RING Ubiquitin E3 ligases (CRLs) play a critical role in targeted protein degradation, essential for physiological development and stress adaptation. The deneddylase activity of the COP9 signalosome (CSN) tightly regulates the cellular balance of neddylated cullins, which is crucial for maintaining the full spectrum of CRL functions. Although selective inositol polyphosphates (InsPs) act as cofactors in plant responses that involve ubiquitylation of negative regulators, their connection to CSN-CRL activities has remained unclear. In this study, we reveal that the two Arabidopsis thaliana InsP-kinases, IPK1 and ITPK1, physically interact and orchestrate the metabolic regulation of the CSN holo-complex activity. Notably, ITPK1 deficiency lowers Nedd8 processing rates, elevates the cellular ratios of neddylated cullins, and disturbs the dissociation equilibrium of CSN5 and CUL1 from the holo-complex. These findings uncover a novel autoregulatory switch in CSN functions, governed by deneddylation activity. Furthermore, we demonstrate that the phosphate starvation response (PSR), induced in phosphate-limited wild-type plants and constitutively active in the InsP-kinase mutants, is partly regulated by reduced deneddylation rates, which affect the stability of SPX4, a key negative regulator of PSR. Pharmacological inhibition of cullin neddylation stabilizes SPX4 and impairs PSR, thereby linking CSN-CRL dynamics to phosphate sensing. Conversely, pharmacologically inhibiting CSN5 deneddylase activity causes wild-type plants to exhibit PSR phenotypes similar to those of the InsP-kinase mutants. Collectively, these results reveal that specific InsP-kinases are partly involved in modulating plant PSR by fine-tuning the coordination between CRL and CSN activities.","PeriodicalId":195,"journal":{"name":"Journal of Integrative Plant Biology","volume":" ","pages":""},"PeriodicalIF":9.3,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SlMED25-SlPHR3-SlSPX2 module fine-tunes SlPHR3-mediated transcriptional activation of phosphate starvation response in tomato. SlMED25-SlPHR3-SlSPX2模块微调slphr3介导的番茄磷酸盐饥饿反应的转录激活。

IF 9.3 1区生物学

Journal of Integrative Plant Biology Pub Date : 2026-05-05 DOI: 10.1111/jipb.70278

Mingtong Zhai, Hongyu Han, Yu Zhang, Yunfeng Zhao, Hongying Guo, Hui Wang, Chuanlong Sun, Xianwen Meng, Lei Deng, Qian Chen, Chuanyou Li

{"title":"SlMED25-SlPHR3-SlSPX2 module fine-tunes SlPHR3-mediated transcriptional activation of phosphate starvation response in tomato.","authors":"Mingtong Zhai, Hongyu Han, Yu Zhang, Yunfeng Zhao, Hongying Guo, Hui Wang, Chuanlong Sun, Xianwen Meng, Lei Deng, Qian Chen, Chuanyou Li","doi":"10.1111/jipb.70278","DOIUrl":"https://doi.org/10.1111/jipb.70278","url":null,"abstract":"Phosphate starvation response (PHR) transcription factors are master regulators of the plant phosphate (Pi) starvation response (PSR), yet the mechanisms governing the dynamic control of their transcriptional activity remain elusive. Here, we report a dual regulatory module comprising the coactivator SlMED25 and the corepressor SlSPX2 that fine-tunes SlPHR3 activity in Solanum lycopersicum (tomato). Genetic and biochemical evidence collectively confirmed that SlPHR3 acts as the central regulator orchestrating tomato PSR. Specifically, the mediator subunit SlMED25 interacts with the N-terminal domain (NTD) of SlPHR3 to recruit RNA polymerase II (Pol II) to SlPHR3 target promoters in a SlPHR3-dependent fashion, whereas SlSPX2 binds to the same NTD of SlPHR3 to robustly suppress its transcriptional activity. Biochemical assays further demonstrated that SlSPX2 and SlMED25 compete for binding to SlPHR3, with SlSPX2 exhibiting higher binding affinity. This competitive binding module functions as a key molecular switch that mediates dynamic PSR modulation in tomato, thus yielding distinct functional outputs in response to varying intracellular Pi levels. Our findings uncover a previously uncharacterized regulatory layer in the PSR network, wherein a Mediator subunit and a Pi-sensing protein modulate PHR activity via competitive binding, thereby enhancing the mechanistic insight into Pi homeostasis regulation in plants.","PeriodicalId":195,"journal":{"name":"Journal of Integrative Plant Biology","volume":" ","pages":""},"PeriodicalIF":9.3,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eukaryotic chaperonin coordinates root meristem activity by regulating SEC31B-dependent COPII vesicle trafficking of PIN auxin efflux carrier in Arabidopsis. 真核伴侣蛋白通过调节sec31b依赖性COPII囊泡运输PIN生长素外排载体来协调根分生组织活性。

IF 9.3 1区生物学

Journal of Integrative Plant Biology Pub Date : 2026-05-04 DOI: 10.1111/jipb.70277

Mengjuan Tong, Yinghui Zhang, Aiwei Zhang, Jingsheng Zhang, Yiqiang Li, Nan Chen, Xiaoyu Liu, Yirui Zhu, Juntao Wang, Shuailei Wang, Zhuoxuan Li, Yi Xu, Sitong Liu, Yi Guo, Rui Li

{"title":"Eukaryotic chaperonin coordinates root meristem activity by regulating SEC31B-dependent COPII vesicle trafficking of PIN auxin efflux carrier in Arabidopsis.","authors":"Mengjuan Tong, Yinghui Zhang, Aiwei Zhang, Jingsheng Zhang, Yiqiang Li, Nan Chen, Xiaoyu Liu, Yirui Zhu, Juntao Wang, Shuailei Wang, Zhuoxuan Li, Yi Xu, Sitong Liu, Yi Guo, Rui Li","doi":"10.1111/jipb.70277","DOIUrl":"https://doi.org/10.1111/jipb.70277","url":null,"abstract":"The eukaryotic chaperonin containing T-complex polypeptide-1 (CCT/TRiC) complex, composed of eight distinct subunits (CCT1-CCT8), is essential for cytosolic protein folding; however, its function in plants remains largely unexplored. Moreover, a direct link between CCT and coat protein complex II (COPII) vesicle trafficking-a key step in the early secretory pathway-has not been established in any eukaryotic system. Here, leveraging plant genetics, we investigated the functional relationship between CCT8 and COPII-mediated trafficking in the Arabidopsis root apex. The point mutant cct8-1 exhibited a short-root phenotype resulting from impaired cell division in the root meristem, which was accompanied by disrupted auxin homeostasis. This defect stemmed from a marked reduction in the abundance of multiple PIN-FORMED (PIN) auxin efflux carriers at the plasma membrane, without affecting their polar localization. Mechanistically, CCT8 directly interacted with SEC31B, a core component of the COPII coat. Accordingly, the sec31b-3 mutant phenocopied cct8-1 in root growth, auxin response, and PIN accumulation defects. The CCT8 mutation reduced SEC31B abundance at both the transcriptional and protein levels and compromised ER-to-Golgi transport, thereby diminishing PIN delivery to the plasma membrane. Importantly, overexpression of SEC31B partially rescued the root growth defects and restored PIN2 levels in cct8-1. Together, our findings uncover a previously unrecognized chaperonin-trafficking module in which CCT8 regulates SEC31B to modulate COPII-mediated delivery of PIN proteins, thus linking chaperonin function to auxin-dependent root development.","PeriodicalId":195,"journal":{"name":"Journal of Integrative Plant Biology","volume":" ","pages":""},"PeriodicalIF":9.3,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genome editing generates high oleic soybean and eliminates beany flavors. 基因编辑产生了高油质大豆，消除了豆味。

IF 9.3 1区生物学

Journal of Integrative Plant Biology Pub Date : 2026-05-04 DOI: 10.1111/jipb.70282

Hongtao Xie, Leping Geng, Ziyi Hu, Feiyang Chen, Mingfang Tan, Dagang Wang, Zhiping Huang, Weijun Ye, Peng Chen, Jianhua Zhu

{"title":"Genome editing generates high oleic soybean and eliminates beany flavors.","authors":"Hongtao Xie, Leping Geng, Ziyi Hu, Feiyang Chen, Mingfang Tan, Dagang Wang, Zhiping Huang, Weijun Ye, Peng Chen, Jianhua Zhu","doi":"10.1111/jipb.70282","DOIUrl":"https://doi.org/10.1111/jipb.70282","url":null,"abstract":"Soybeans serve as excellent sources of vegetable oil, protein, and other valuable nutrients for human consumption, materials for diverse industries, including the cosmetics and medical industries, and feedstocks for animals. Nevertheless, some people do not favor soy oil or other various food products derived from soybeans, due to inadequate levels of oleic acid in the oil and the presence of undesirable grassy and beany flavors associated with oxidation products of polyunsaturated fatty acids in the seeds. In this study, we developed soybean cultivars with very high levels of oleic acid in the seeds, and without grassy and beany flavors. We achieved this by using CRISPR-Cas-SF01 to edit genes in the elite cultivar Xudou 18 (XD18), targeting two microsomal Δ-12 fatty acid desaturase 2 (GmFAD2-1A and GmFAD2-1B) and three lipoxygenase (GmLOX1, GmLOX2, and GmLOX3) genes. Our findings showed that fad2-1a/b and fad2-1a/b/lox1/2/3 plants performed similarly to XD18 plants in the field, indicating no obvious growth penalties. Overall, this research has demonstrated that the development of soybean germplasms with high levels of oleic acid and without undesirable beany flavors through gene-editing of multiple relevant genes is effective, and this endeavor can contribute to the health of a broader global consumer population.","PeriodicalId":195,"journal":{"name":"Journal of Integrative Plant Biology","volume":" ","pages":""},"PeriodicalIF":9.3,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The receptor-like pseudokinase LENG stimulates chilling tolerance in rice by inhibiting the activity of the OsCRPK1-OsGF14d module. 受体样假激酶LENG通过抑制OsCRPK1-OsGF14d模块的活性来刺激水稻的抗寒性。

IF 9.3 1区生物学

Journal of Integrative Plant Biology Pub Date : 2026-05-01 Epub Date: 2026-01-20 DOI: 10.1111/jipb.70148

Shuting Yuan, Chunjue Xu, Xia Wang, Wei Yan, Xiaojie Hua, Yi Zhuang, Cuifang Wang, Changjian Wang, Yihang Gong, Jianxin Wu, Letian Chen, Xiaoyan Tang, Wenbo Pan

{"title":"The receptor-like pseudokinase LENG stimulates chilling tolerance in rice by inhibiting the activity of the OsCRPK1-OsGF14d module.","authors":"Shuting Yuan, Chunjue Xu, Xia Wang, Wei Yan, Xiaojie Hua, Yi Zhuang, Cuifang Wang, Changjian Wang, Yihang Gong, Jianxin Wu, Letian Chen, Xiaoyan Tang, Wenbo Pan","doi":"10.1111/jipb.70148","DOIUrl":"10.1111/jipb.70148","url":null,"abstract":"Cold damage during the seedling and reproductive stages has a pronounced impact on rice development and yield. Although significant progress has been achieved in understanding the physiological and molecular mechanisms underlying rice responses to cold stress, the mechanisms of cold stress perception and adaptation in rice remain mostly unclear. Here, we report the functional study of a cold-responsive gene named LENG, which encodes a plasma membrane-localized leucine-rich repeat (LRR) receptor-like pseudokinase. Gene knockout and overexpression analyses indicated that LENG positively regulates chilling tolerance in rice seedlings. LENG interacts with the plasma membrane-localized cytoplasmic protein kinase, cold-responsive protein kinase 1 (OsCRPK1). Knockout of OsCRPK1 in wild-type and leng mutants elevates rice chilling tolerance, indicating that OsCRPK1 plays a negative role and acts downstream of LENG. In vitro kinase assays revealed that OsCRPK1 is an active protein kinase, but it does not phosphorylate LENG, whereas LENG does not have a kinase activity, but it suppresses the kinase activity of OsCRPK1. In addition, LENG interferes with the interaction between OsCRPK1 and the rice 14-3-3 protein OsGF14d (G-box factor 14-3-3 homolog d), which is known to be a positive regulator of chilling tolerance. The polymorphisms in the promoter and coding region of LENG in japonica and indica rice were correlated with the differential gene expression patterns and chilling tolerance in response to chilling treatment. Taken together, these findings suggest that LENG regulates rice chilling tolerance by modulating the kinase activity of OsCRPK1 and eventually the phosphorylation status of OsGF14d protein. The polymorphisms in LENG provide a selection marker for molecular breeding of rice with improved chilling tolerance.","PeriodicalId":195,"journal":{"name":"Journal of Integrative Plant Biology","volume":" ","pages":"1333-1348"},"PeriodicalIF":9.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13140070/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146008010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Geminivirus V2-mediated inhibition of plant FKBP13 PPIase activity activates UPR signaling to enhance viral pathogenicity. 双子星病毒v2介导的植物FKBP13 PPIase活性抑制激活UPR信号以增强病毒致病性。

IF 9.3 1区生物学

Journal of Integrative Plant Biology Pub Date : 2026-05-01 Epub Date: 2026-02-05 DOI: 10.1111/jipb.70170

Pengbai Li, Keda Han, Gaohua Wang, Chengcheng Li, Jun Zhao, Jingke Bai, Jiao Du, Chaonan Wang, Honglian Li, Ling Qing, Chao Zhang

{"title":"Geminivirus V2-mediated inhibition of plant FKBP13 PPIase activity activates UPR signaling to enhance viral pathogenicity.","authors":"Pengbai Li, Keda Han, Gaohua Wang, Chengcheng Li, Jun Zhao, Jingke Bai, Jiao Du, Chaonan Wang, Honglian Li, Ling Qing, Chao Zhang","doi":"10.1111/jipb.70170","DOIUrl":"10.1111/jipb.70170","url":null,"abstract":"The unfolded protein response (UPR) serves as a crucial regulatory mechanism that enables eukaryotic cells to mitigate endoplasmic reticulum (ER) stress and plays a significant role in plant antiviral immunity. In this study, we show that V2 protein encoded by the tomato yellow leaf curl virus (TYLCV) induces severe necrotic symptoms in Nicotiana benthamiana and tomato plants. V2 activates the host UPR, and this activation promotes TYLCV infection. Furthermore, we demonstrate that V2 directly interacts with NbFKBP13, a rate-limiting enzyme in protein folding, and inhibits its enzymatic activity. Genetic analysis revealed that NbFKBP13 significantly attenuates V2-induced UPR activation and cell death while enhancing N. benthamiana resistance against TYLCV infection. Similarly, V2 interacts with SlFKBP13, the tomato homolog of NbFKBP13, and SlFKBP13 improves tomato resistance to TYLCV infection. Moreover, both TYLCV infection and V2 expression induce autophagy, a process in which NbFKBP13 plays a crucial role. Notably, the activation of autophagy inhibits TYLCV infection. Our results unveil a molecular mechanism through which the geminivirus V2 protein manipulates the host UPR to facilitate viral infection. These findings significantly advance our understanding of the evolutionary arms race between plants and viruses.","PeriodicalId":195,"journal":{"name":"Journal of Integrative Plant Biology","volume":" ","pages":"1542-1556"},"PeriodicalIF":9.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146122878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The VQ motif-containing proteins VQ18 and VQ26 regulate flowering time in Arabidopsis thaliana. 含有VQ基序的蛋白VQ18和VQ26调控拟南芥的开花时间。

IF 9.3 1区生物学

Journal of Integrative Plant Biology Pub Date : 2026-05-01 Epub Date: 2026-01-28 DOI: 10.1111/jipb.70164

Xia Li, Siyuan Liu, Lei Liu, Donglian Tao, Shidie Chen, Zhiyu Xu, Wanqin Chen, Ting Wang, Pingping Li, Jiannan Feng, Tianyu Yang, Xingchen Pan, Wenyi Zhou, Yi Zhu, Zhichuang Yue, Diqiu Yu, Houping Wang

{"title":"The VQ motif-containing proteins VQ18 and VQ26 regulate flowering time in Arabidopsis thaliana.","authors":"Xia Li, Siyuan Liu, Lei Liu, Donglian Tao, Shidie Chen, Zhiyu Xu, Wanqin Chen, Ting Wang, Pingping Li, Jiannan Feng, Tianyu Yang, Xingchen Pan, Wenyi Zhou, Yi Zhu, Zhichuang Yue, Diqiu Yu, Houping Wang","doi":"10.1111/jipb.70164","DOIUrl":"https://doi.org/10.1111/jipb.70164","url":null,"abstract":"Floral induction in plants represents a critical developmental transition from vegetative growth to the reproductive phase, which is vital for reproductive success. Identifying new genes that control flowering time and understanding their regulatory mechanisms is crucial for improving our knowledge of plant adaptability to the environment. Here, we identify VQ motif-containing proteins VQ18 and VQ26 as novel promoters of flowering that function redundantly to regulate this process in Arabidopsis. The VQ18 and VQ26 proteins promote flowering in Arabidopsis through their interaction with the CONSTANS (CO) protein. This interaction enhances the stability of the CO protein and augments its transcriptional activation of the FLOWERING LOCUS T (FT) gene. Furthermore, VQ18 and VQ26 exhibit binding affinity for the TARGET OF EAT1 (TOE1) and TOE2 proteins, thereby diminishing the binding affinity and inhibitory effects of TOEs on FT, which alleviates the repression of flowering by TOEs. Additionally, VQ18 and VQ26 are implicated in the regulation of flowering timing by competing with TOEs for interaction with CO. Our findings broaden the functions of VQ proteins and reveal new regulatory interactions in the flowering network, providing insights into how plants balance positive and negative signals to regulate flowering time.","PeriodicalId":195,"journal":{"name":"Journal of Integrative Plant Biology","volume":"68 5","pages":"1421-1438"},"PeriodicalIF":9.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AlkaPlorer: A database-driven explorer for natural alkaloids and derivatives. AlkaPlorer：一个数据库驱动的天然生物碱及其衍生物的资源管理器。

IF 9.3 1区生物学

Journal of Integrative Plant Biology Pub Date : 2026-05-01 Epub Date: 2026-02-05 DOI: 10.1111/jipb.70173

Jiahao Li, Tao Zeng, Hongquan Xu, Xu Kang, Minghui Liang, Ruibo Wu

{"title":"AlkaPlorer: A database-driven explorer for natural alkaloids and derivatives.","authors":"Jiahao Li, Tao Zeng, Hongquan Xu, Xu Kang, Minghui Liang, Ruibo Wu","doi":"10.1111/jipb.70173","DOIUrl":"10.1111/jipb.70173","url":null,"abstract":"Alkaloids, renowned for their pivotal physiological roles in plant defense and chemical medium, constitute a structurally diverse class of bioactive natural products with substantial therapeutic potential in modern drug development. There is currently no dedicated alkaloid database, highlighting an urgent need for such a resource. Here, we present AlkaPlorer (https://alkaplorer.qmclab.com/), the first systematic alkaloid database, which has compiled over 130,000 alkaloids from 12,250 species, with reported activity against 6,583 biological targets. AlkaPlorer not only integrates comprehensive experimentally validated data and computationally predicted properties for each alkaloid, but also establishes standardized notation and associations among various data elements, forming a correlative-type dataset. Extensive chemoinformatic analyses on structural scaffolds, biosynthetic precursors, physicochemical properties, and phylogenetic distributions across plant taxa are performed based on AlkaPlorer, providing new insights into the chemical diversity, structural evolution, and biosynthetic regularity of plant alkaloids. AlkaPlorer enables easy access and efficient retrieval and provides a foundational resource for AI-driven applications in plant metabolism and alkaloid research.","PeriodicalId":195,"journal":{"name":"Journal of Integrative Plant Biology","volume":" ","pages":"1384-1398"},"PeriodicalIF":9.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13140036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146123200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0