Nutrition最新文献

{"title":"Effect of a high-fat high-fructose diet on the composition of the intestinal microbiota and its association with metabolic and anthropometric parameters in a letrozole-induced mouse model of polycystic ovary syndrome","authors":"Joanna Maria Pieczyńska-Zając ,&nbsp;Anna Maria Malinowska ,&nbsp;Ewa Pruszyńska-Oszmałek ,&nbsp;Paweł Antoni Kołodziejski ,&nbsp;Sławomira Drzymała-Czyż ,&nbsp;Joanna Bajerska","doi":"10.1016/j.nut.2024.112450","DOIUrl":"https://doi.org/10.1016/j.nut.2024.112450","url":null,"abstract":"<div><h3>Objective</h3><p>It has been suggested that dysbiosis of the gut microbiota is associated with the pathogenesis of Polycystic Ovary Syndrome (PCOS), and that improper diet can aggravate these changes. This study thus aimed to investigate the effects of a high-fat/high-fructose (HF/HFr) diet on the gut microbial community and their metabolites in prepubertal female mice with letrozole (LET)-induced PCOS. We also tested the correlations between the relative abundance of microbial taxa and selected PCOS parameters.</p></div><div><h3>Research methods &amp; procedures</h3><p>Thirty-two C57BL/6 mice were randomly divided into four groups (n = 8) and implanted with LET or a placebo, with simultaneous administration of a HF/HFr diet or standard diet (StD) for 5 wk. The blood and intestinal contents were collected after the sacrifice.</p></div><div><h3>Results</h3><p>Placebo + HF/HFr and LET + HF/HFr had significantly higher microbial alpha diversity than either group fed StD. The LET-implanted mice fed StD had a significantly higher abundance of <em>Prevotellaceae_UCG-001</em> than the placebo mice fed StD. Both groups fed the HF/HFr diet had significantly lower fecal levels of short-chain fatty acids than the placebo mice fed StD, while the LET + HF/HFr animals had significantly higher concentrations of lipopolysaccharides in blood serum than either the placebo or LET mice fed StD. Opposite correlations were observed between <em>Turicibacter</em> and <em>Lactobacillus</em> and the lipid profile,</p></div><div><h3>Conclusion</h3><p>HF/HFr diet had a much stronger effect on the composition of the intestinal microbiota of prepubertal mice than LET itself.</p></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S089990072400100X/pdfft?md5=dba8045da98b1d0d09b4fb5d5280610c&pid=1-s2.0-S089990072400100X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140646614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review on vitamin A deficiency and depleted immunity in South Asia: From deficiency to resilience","authors":"Rahul Kumar ,&nbsp;Maria Jose Oruna-Concha ,&nbsp;Keshavan Niranjan ,&nbsp;Karani S. Vimaleswaran","doi":"10.1016/j.nut.2024.112452","DOIUrl":"https://doi.org/10.1016/j.nut.2024.112452","url":null,"abstract":"<div><p>In the developing world, the twin challenges of depleted health and growing issue of food waste management loom large, demanding simultaneous attention and innovative solutions. This review explores how these issues can be effectively mitigated while shedding light on the transformative impact of food waste valorization on health management. A spotlight is cast on vitamin A deficiency (VAD), an acute public health concern, especially prevalent in South Asia, driven by economic constraints, sociocultural factors, inadequate diets, and poor nutrient absorption. VAD's devastating effects are exacerbated by limited education, lack of sanitation, ineffective food regulations, and fragile monitoring systems, disproportionately affecting children and women of childbearing age. Recent studies in South Asian countries have revealed rising rates of illness and death, notably among children and women of childbearing age, due to VAD. To address inadequate dietary intake in children utilizing vegetable waste, particularly from carrots and beetroot, which are rich in <em>β</em>-carotene, and betalains, respectively, offers a sustainable solution. Extracting these compounds from vegetable waste for supplementation, fortification, and dietary diversification could significantly improve public health, addressing both food waste and health disparities economically. This approach presents a compelling avenue for exploration and implementation. In summary, this review presents an integrated approach to tackle health and food waste challenges in the developing world. By tapping into the nutritional treasure troves within vegetable waste, we can enhance health outcomes while addressing food waste, forging a brighter and healthier future for communities in need.</p></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0899900724001023/pdfft?md5=2c8793afb10bb4332fa7ec811f022016&pid=1-s2.0-S0899900724001023-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140646615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Barriers and facilitators to nutritional recommendations identified by participants of a cardiovascular rehabilitation program in a low resource context in Brazil","authors":"Camila Kümmel Duarte R.D., Ph.D. ,&nbsp;Luciana de Abreu Silva R.D., M.Sc. ,&nbsp;Paula Moraes Berti de Andrade ,&nbsp;Tábata Monaliza Marcelino Martins ,&nbsp;Gabriela Lima de Melo Ghisi P.T., Ph.D.","doi":"10.1016/j.nut.2024.112451","DOIUrl":"10.1016/j.nut.2024.112451","url":null,"abstract":"<div><h3>Objectives</h3><p>Nutritional recommendations, a core component of cardiovascular rehabilitation, play a vital role in managing cardiovascular diseases. However, adherence to these recommendations is complex, particularly in low-resource settings. This study explored the barriers and facilitators influencing adherence to nutritional recommendations among participants in a low-resource cardiovascular rehabilitation program in Brazil.</p></div><div><h3>Methods</h3><p>A mixed-methods approach was employed. Sociodemographic data, the Mediterranean diet score, scale for assessing nutrition, and open-ended questions on adherence were collected. Those who completed the questionnaires (phase 1) were invited to participate in one focus group session (phase 2). The participants were characterized according to the responses provided in phase 1 (Mediterranean diet score and scale for assessing nutrition) in low adherence or high adherence to dietary practice. Descriptive statistics and thematic content analysis within the context of the theory of planned behavior were employed.</p></div><div><h3>Results</h3><p>Seventy-four participants completed phase 1, with 41.9% classified into low adherence and 27.0% in high adherence; of those, 17 participated in phase 2. Focus group findings revealed 9 themes/29 subthemes. Barriers included food prices, income, knowledge, routine, food access, family patterns, disease, work, anxiety, eating habits, and food planning. Facilitators included affordable food, health considerations, taste preferences, knowledge, family/professional support, government assistance, personal willpower, income stability, easy food access, media influence, and a quiet eating place.</p></div><div><h3>Conclusions</h3><p>The study findings underscore the need for targeted interventions, including individualized meal planning, community engagement, and enhanced access to healthcare professionals, to optimize dietary adherence and improve cardiovascular outcomes.</p></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0899900724001011/pdfft?md5=7246764a29d779cf8c5eabd2a2c2da71&pid=1-s2.0-S0899900724001011-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140782039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proposal and validation of an equation to identify sarcopenia using bioelectrical impedance analysis-derived parameters","authors":"Takashi Shida ,&nbsp;Sho Hatanaka ,&nbsp;Takahisa Ohta ,&nbsp;Yosuke Osuka ,&nbsp;Narumi Kojima ,&nbsp;Keiko Motokawa ,&nbsp;Masanori Iwasaki ,&nbsp;Fumiko Miyamae ,&nbsp;Tsuyoshi Okamura ,&nbsp;Hirohiko Hirano ,&nbsp;Shuichi Awata ,&nbsp;Hiroyuki Sasai","doi":"10.1016/j.nut.2024.112453","DOIUrl":"https://doi.org/10.1016/j.nut.2024.112453","url":null,"abstract":"<div><h3>Objective</h3><p>This study aimed to develop a simpler approach for diagnosing sarcopenia by using only bioelectrical impedance vector analysis parameters.</p></div><div><h3>Methods</h3><p>The study design was a cross-sectional study. The research was conducted based on the Itabashi Longitudinal Study on Aging, a community-based cohort study, with data collected from the 2022 and 2023 surveys in Itabashi Ward, Tokyo, Japan. The development cohort consisted of 1146 participants from the 2022 survey, and the validation cohort included 656 participants from the 2023 survey. Both cohorts were comprised of community-dwelling older adults with similar inclusion criteria. Sarcopenia was defined according to the Asian Working Group for Sarcopenia 2019 criteria. The logistic model utilized height divided by impedance at 50 kHz and phase angle to establish a new regression equation to identify sarcopenia. Regression equations were generated for the development cohort and validated for the validation cohort. Discriminatory ability was assessed using the area under the receiver operating characteristic curve (AUC) for men and women.</p></div><div><h3>Results</h3><p>The prevalence of sarcopenia was 20.7% and 14.8% in the development and validation cohort, respectively. The AUC (95% confidence interval) of the logistic model in discriminating sarcopenia was 0.92 (0.88, 0.95) for men and 0.82 (0.78, 0.86) for women in the development cohort and 0.85 (0.78, 0.91) for men and 0.90 (0.86, 0.95) for women in the validation cohort.</p></div><div><h3>Conclusion</h3><p>The study demonstrated that a simple formula using bioelectrical parameters at 50 kHz proved useful in identifying sarcopenia in the older adult population.</p></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140645124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How xylitol, gluten, and lactose change human gut microbiota Escherichia coli and Lactobacillus rhamnosus GG biofilm","authors":"Joanna Kwiecińska-Piróg ,&nbsp;Karolina Chomont ,&nbsp;Dagmara Fydrych ,&nbsp;Julita Stawarz ,&nbsp;Tomasz Bogiel ,&nbsp;Jana Przekwas ,&nbsp;Eugenia Gospodarek-Komkowska","doi":"10.1016/j.nut.2024.112446","DOIUrl":"10.1016/j.nut.2024.112446","url":null,"abstract":"<div><p><em>Objective:</em> The human gut microbiota is composed of many viruses, bacteria, and fungi. <em>Escherichia coli</em> representatives are facultative anaerobic bacteria in the colon that play a crucial role in the metabolism of lactose, vitamin synthesis, and immune system modulation. <em>E. coli</em> forms a biofilm on the epithelial cell surface of the intestine that can be modified by diet compounds, i.e., gluten, xylitol, lactose, and probiotics.</p><p><em>Methods:</em> In the present study, the impact of probiotic-derived <em>Lactobacillus rhamnosus</em> GG strain on non-pathogenic <em>E. coli</em> biofilm was examined. The mono- and multispecies biofilm was also treated with gluten, xylitol, and lactose. We used 96-well plates to obtain biofilm growth. Biofilm was stained using crystal violet. To evaluate the type of interaction in mono- and multispecies biofilm, a new formula was introduced: biofilm interaction ratio index (BIRI). To describe the impact of nutrients on biofilm formation, the biofilm formation impact ratio (BFIR) was calculated.</p><p><em>Results:</em> The biofilms formed by both examined species are stronger than in monocultures. All the BIRI values were above 3.0. It was found that the monospecies biofilm of <em>L. rhamnosus</em> is strongly inhibited by gluten (84.5%) and the monospecies biofilm of <em>E. coli</em> by xylitol (85.5%). The mixed biofilm is inhibited by lactose (78.8%) and gluten (90.6%).</p><p><em>Conclusion:</em> The relations between bacteria in the mixed biofilm led to changes in biofilm formation by <em>E. coli</em> and <em>L. rhamnosus</em> GG. Probiotics might be helpful in rebuilding the gut microbiota after broad spectrum antibiotic therapy, but only if gluten and lactose are excluded from diet.</p></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140772848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of oral nutritional supplement composition on healing of different chronic wounds: A systematic review","authors":"Allan Carlos Soares do Espírito Santo M.Sc. ,&nbsp;Clara Sandra de Araújo Sugizaki Ph.D. ,&nbsp;Alcides Corrêa de Morais Junior Ph.D. ,&nbsp;Nara Aline Costa Ph.D. ,&nbsp;Maria Marcia Bachion Ph.D. ,&nbsp;João Felipe Mota Ph.D.","doi":"10.1016/j.nut.2024.112449","DOIUrl":"https://doi.org/10.1016/j.nut.2024.112449","url":null,"abstract":"<div><p>Chronic wounds are characterized by prolonged non-healing, significantly affecting patients' quality of life. Oral formulas may enhance the wound healing process and contribute to cost reduction in care. This review aimed to evaluate the effects of oral nutritional supplementation on chronic wound healing and provide insights into formula characteristics. A comprehensive search across Cinahl, Embase, PubMed, and Web of Science databases yielded nine studies from the past decade involving 741 patients ages 52 to 81.7 across various care settings: hospitals, long-term care facilities, and home care. Primary wound types included pressure injuries (58%), diabetic foot ulcers (40%), and venous ulcers (2%). The intervention duration ranged from 2 to 16 wk, with sample sizes varying from 24 to 270 patients. Notably, four studies reported a reduction in wound area and an increased healing rate with a hypercaloric, hyperproteic formula enriched with zinc and vitamins A, C, and E. However, two studies found no significant differences compared with control groups. Two other studies investigated a combination of arginine, glutamine, and β-hydroxy-β-methylbutyrate; however, they did not yield significant results, and one study favored a hyperproteic formula instead of a hyperproteic formula with arginine. This review provides evidence supporting the potential of oral nutritional supplementation to enhance the healing process of chronic wounds. Based on our findings, a desirable formula should be characterized by a high calorie and protein content and the inclusion of antioxidant micronutrients, including, but not limited to, vitamins A, E, C, and zinc.</p></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140816465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High adherence to the French dietary guidelines decreases type 2 diabetes risk in females through pathways of obesity markers: Evidence from the E3N-EPIC prospective cohort study","authors":"Daouda Seck MD, MPH ,&nbsp;Sanam Shah FCPS, PhD ,&nbsp;Emmanuelle Correia Licence ,&nbsp;Chloé Marques MS ,&nbsp;Raphaëlle Varraso PhD ,&nbsp;Bamba Gaye PhD ,&nbsp;Marie-Christine Boutron-Ruault MD, PhD ,&nbsp;Nasser Laouali PhD","doi":"10.1016/j.nut.2024.112448","DOIUrl":"https://doi.org/10.1016/j.nut.2024.112448","url":null,"abstract":"<div><h3>Objective</h3><p>Obesity and type 2 diabetes (T2D) have been associated with low adherence to the 2017 French food-based dietary guidelines, as assessed by the <em>Programme National Nutrition Santé</em> - guidelines score 2 (PNNS-GS2). Whether the association between T2D and PNNS-GS2 is direct or mediated by obesity has been little investigated.</p></div><div><h3>Research methods</h3><p>The study included 71,450 women from the E3N-EPIC cohort, mean age of 52.9 y (SD 6.7). The simplified PNNS-GS2 was derived via food history questionnaire. Multivariable Cox regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of T2D. Causal mediation analyses were used to decompose the total effect of sPNNS-GS2 on T2D into a direct effect and indirect effect mediated by body mass index (BMI) or the waist-hip ratio (WHR).</p></div><div><h3>Results</h3><p>During a mean follow-up of 19 y, 3679 incident T2D cases were identified and validated. There was a linear association between adherence to sPNNS-GS2 and T2D (P-nonlinearity = 0.92). In the fully adjusted model, each 1-SD increase in the sPNNS-GS2 was associated with a lower T2D risk [HR (95% CI), 0.92 (0.89, 0.95)]. The overall associations were mainly explained by sPNNS-GS2-associated excess weight, with BMI and WHR mediating 52% and 58% of the associations, respectively.</p></div><div><h3>Conclusions</h3><p>Higher adherence to French food-based dietary guidelines was associated with a lower risk of T2D in women, and a significant portion of this effect could be attributed to excess weight measured by BMI or WHR. This finding helps better understand the mechanisms underlying the diet-T2D association.</p></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140647618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential role of Vitamin D in immune response in patients with viral hepatitis","authors":"Catharina Gerhards ,&nbsp;Andreas Teufel ,&nbsp;Marlis Gerigk ,&nbsp;Michael French ,&nbsp;Christoph Antoni ,&nbsp;Matthias Ebert ,&nbsp;Michael Neumaier ,&nbsp;Osman Evliyaoglu","doi":"10.1016/j.nut.2024.112447","DOIUrl":"10.1016/j.nut.2024.112447","url":null,"abstract":"<div><h3>Background</h3><p>To study the relationship of Vitamin D with innate and adaptive immune response parameters in chronic hepatitis B and C patients.</p></div><div><h3>Methods</h3><p>The laboratory data between January 1, 2013 and February 1, 2023, for patients with chronic hepatitis B (CHB), and chronic hepatitis C (CHC) were extracted. Serum 25-hydroxyl vitamin D, hepatitis B virus serological markers, complements, and subsets of T lymphocytes were determined. Study cohorts were divided into groups based on serum 25-hydroxyl vitamin D levels with further evaluation of laboratory data.</p></div><div><h3>Results</h3><p>In CHB and CHC patients the percentage of CD4+ T lymphocytes and the CD4+/CD8+ ratio significantly decreased (<em>P</em> &lt; 0.05), but the percentage of CD8+ increased (<em>P</em> &lt; 0.05) compared to the control group. In CHB patients Vitamin D decrease was significant (<em>P</em> &lt; 0.001) but not in CHC patients. Vitamin D showed a moderate negative influence on the CD8 cell count in CHB patients. The positive ratio of HBV DNA and HBsAg decreased with increasing serum vitamin D levels. The vitamin D deficient group showed significantly lower antibody production compared to the normal group, and exhibited significantly decreased CD4 numbers and increased CD8 numbers (<em>P</em> &lt; 0.05 and <em>P</em> &lt; 0.001, respectively), while the CD4/CD8 ratio was also significantly decreased in the insufficiency group (<em>P</em> &lt; 0.001). Complement C3 levels were not associated with CD4 and CD8, but had an inverse relation with Vitamin D. Vitamin D levels were significantly associated with complement C3, CD8+, CD4+, CD19+ cells, and HBV DNA levels.</p></div><div><h3>Conclusions</h3><p>Vitamin D may be a modulator of immune function not only via CD8+ and CD4+ cells but also via CD19+ cells in the course of chronic HBV infection. The negative relationship between vitamin D and complement C3 needs elucidation. Moreover, the increased proportion of B cells and decreased CD4+ cells in Vitamin D deficiency disrupt the immune response against HBV since the expected antibody response was not obtained despite the increase in B cell ratio. This indicates an influence of CD4+ cells for B cell functionality. In summary, sufficient levels of Vitamin D may lead to a sustained virological response that is debatable by artificially correcting the deficiency.</p></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0899900724000972/pdfft?md5=0482841e597593fadc84e6c230dc6fcb&pid=1-s2.0-S0899900724000972-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140404258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are the nutritional status and growth parameters of children with juvenile idiopathic arthritis akin to their healthy peers? A single-center experience","authors":"Özlem Akgün MD ,&nbsp;Beyza Eliuz Tipici MD ,&nbsp;Işık Gülcan Kahraman ,&nbsp;Vafa Guliyeva MD ,&nbsp;Fatma Gül Demirkan MD ,&nbsp;Melike Zeynep Tuğrul Aksakal MD ,&nbsp;Nuray Aktay Ayaz MD","doi":"10.1016/j.nut.2024.112439","DOIUrl":"10.1016/j.nut.2024.112439","url":null,"abstract":"<div><h3>Objective</h3><p>Proper nutrition is a significant contributor to growth achievement in patients with juvenile idiopathic arthritis (JIA). In this study, the aim was to analyze the growth parameters and nutritional status of children with JIA and then compare them with their healthy peers.</p></div><div><h3>Methods</h3><p>A cross-sectional study was conducted with 54 patients with JIA and the same number of healthy peers. Growth parameter z-scores and nutrient distributions were analyzed and compared with a control group and among disease subgroups.</p></div><div><h3>Results</h3><p>While the average height in the control group was significantly greater than in the patient group, there was similarity in terms of body weight and body mass index (BMI) (<em>P &lt;</em> 0.001, <em>P =</em> 0.33, <em>P =</em> 0.14, respectively). Body weight and BMI z-scores of patients with high disease activity at the most recent visit were significantly lower (<em>P =</em> 0.03, <em>P =</em> 0.01, respectively). Both groups had similar energy and protein requirement–meeting percentages (<em>P =</em> 0.62, <em>P =</em> 0.51). JIA atients had higher carbohydrate intake (<em>P =</em> 0.04), and fat intake was higher in controls (<em>P =</em> 0.02). Energy obtained from junk food was higher in patients with entesitis-related arthritis (ERA) compared to oligoarticular JIA and polyarticular JIA (<em>P =</em> 0.03). Micronutrient intake in the ERA group was significantly lower for vitamin E, C, and folate (<em>P =</em> 0.02, <em>P =</em> 0.03, <em>P &lt;</em> 0.001).</p></div><div><h3>Conclusion</h3><p>In our cohort, patients had a lower height score. As they have a diet characterized by adequate energy/protein, carbohydrate, and high fat intake, this may be a reflection of disease activity. Although some of the micronutrient intakes were less than normal in both groups, significant deficiencies were identified in the ERA group.</p></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140398374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments on \"Guidelines to restrict consumption of red meat to under 350g/week based on colorectal cancer risk are not consistent with health evidence\"","authors":"William B. Grant Ph.D.","doi":"10.1016/j.nut.2024.112443","DOIUrl":"10.1016/j.nut.2024.112443","url":null,"abstract":"","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140401904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}