Nutrition最新文献

{"title":"Re. “Nutri-Score effectiveness in improving consumers’ nutrition literacy, food choices, health, and healthy eating pattern adherence: A systematic review” by Muzzioli et al.","authors":"Ferard Clémentine, Fezeu K. Léopold, Galan Pilan, Hercberg Serge, Touvier Mathilde, Julia Chantal","doi":"10.1016/j.nut.2025.113010","DOIUrl":"10.1016/j.nut.2025.113010","url":null,"abstract":"","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"143 ","pages":"Article 113010"},"PeriodicalIF":3.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145743673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fabrication and characterization of chickpea-based supplements for their functional, structural, and organoleptic properties","authors":"Iraj Fatima ,&nbsp;Muhammad Kashif Iqbal Khan ,&nbsp;Muhammad Aamir ,&nbsp;Muhammad Mahboob Ali Hamid","doi":"10.1016/j.nut.2025.113018","DOIUrl":"10.1016/j.nut.2025.113018","url":null,"abstract":"<div><h3>Background</h3><div>The COVID-19 pandemic exacerbated nutritional deficiencies, leading to a shift toward caloric-dense foods.</div></div><div><h3>Objective</h3><div>The current research aimed to analyze various Nutrisure formulas based on roasted chickpeas, nuts, seeds, and psyllium husk.</div></div><div><h3>Method</h3><div>Beetroot and turmeric powders were added to enhance the nutritional and functional properties of the formulas, and freshly prepared Nutrisure samples were stored at room temperature (20 ± 5°C) for 60 d.</div></div><div><h3>Results</h3><div>The results indicate that the Nutrisure formulas contained higher protein, fat, and fiber concentrations than the control formula. The antioxidant capacity of the Nutrisure formulas, such as total phenolic content, total flavonoid content, Ferric reducing antioxidant power, and 2,2-diphenyl-picrylhydrazyl, were also higher at 2.46–2.56 µg gallic acid equivalents/g, 3.18–3.23 µg quercetin equivalents/g, 7.21–7.84 µmol trolox equivalent/g, and 81.23–83.02%, respectively.</div></div><div><h3>Conclusion</h3><div>In conclusion, this study determined that the Nutrisure formulations are shelf-stable, nutrient-dense, and can help to provide sustainable nutritional security.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"143 ","pages":"Article 113018"},"PeriodicalIF":3.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145733787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"More mindful, more selective, more disordered? A mediation analysis of picky eating in the link between mindful eating and orthorexia nervosa tendency","authors":"Gizem Özata-Uyar Ph.D. ,&nbsp;Serkan Aslan Ph.D. ,&nbsp;Merve Arslan M.Sc. ,&nbsp;Ayşe Çamli M.Sc. ,&nbsp;Osman Bozkurt Ph.D. ,&nbsp;Betül Kocaadam-Bozkurt Ph.D.","doi":"10.1016/j.nut.2025.113078","DOIUrl":"10.1016/j.nut.2025.113078","url":null,"abstract":"<div><h3>Aim</h3><div>This study evaluated the relationship between picky eating, mindful eating (ME), orthorexia nervosa (ON) tendency, and diet quality in adults. The secondary aim was to examine whether picky eating mediates the effect of ME on ON tendency.</div></div><div><h3>Methods</h3><div>A total of 541 adults (mean age 26.6 ± 10.54 y, 50.6% women) participated. Data were collected using a structured questionnaire via face-to-face interviews and convenience sampling. Picky eating (PE) was assessed with the Adult Picky Eating Questionnaire, ME with the ME Inventory (MEI), ON tendency with the Test of ON-17 (TON-17), and diet quality with the Healthy Eating Index-2020. Dietary intake was measured using a 24-h dietary recall.</div></div><div><h3>Results</h3><div>Among participants, 5.2% had ON, and 41.6% had inadequate diet quality. MEI was positively associated with PE (<em>β</em> = 0.108; <em>P</em> = 0.013) and TON-17 (<em>β</em> = 0.093; <em>P</em> = 0.025). PE was positively associated with TON-17 (<em>β</em> = 0.213; <em>P</em> &lt; 0.001) and negatively associated with Healthy Eating Index-2020 (<em>β</em> = –0.126; <em>P</em> = 0.003). The indirect effect of MEI on TON-17 via PE accounted for 19.8% of the total effect, indicating that PE partially mediated this relationship.</div></div><div><h3>Conclusions</h3><div>The findings suggest that ME is associated with healthier dietary behavior; however, they may also be related to increased orthorexic tendencies. It also showed that PE mediates between MEI and TON-17. Addressing selective eating behaviors and encouraging balanced, ME in public health strategies may help improve diet quality and reduce eating related problems.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"143 ","pages":"Article 113078"},"PeriodicalIF":3.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145864054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of dietary management and monitoring practices in pharmaceutical clinical trials for inborn errors of metabolism","authors":"Nicole Y. McWhorter MS, RD ,&nbsp;Tracy B. Lowe PhD, RN ,&nbsp;Sara M. Sarasua PhD ,&nbsp;Christopher L. Farrell PhD ,&nbsp;Melanie B. Gillingham PhD, RD","doi":"10.1016/j.nut.2025.113024","DOIUrl":"10.1016/j.nut.2025.113024","url":null,"abstract":"<div><h3>Background</h3><div>Inborn errors of metabolism (IEMs) are rare genetic conditions that often require strict dietary management to prevent serious health complications. With the rise of pharmaceutical therapies for IEMs, clinical trials now use diet-sensitive biomarkers to assess drug efficacy. However, uncontrolled dietary variation can confound biomarker outcomes. This review evaluates how diet is managed and monitored in pharmaceutical clinical trials for IEMs and compares those practices against FDA guidance and validated nutrition assessment standards.</div></div><div><h3>Methods</h3><div>An analytic narrative review was conducted from November 2023 to March 2024 using Cochrane Library searches. Seventeen clinical trials met inclusion criteria, involving phenylketonuria (PKU), fatty-acid oxidation disorders, and methylmalonic/propionic acidemia. Each trial was evaluated against 14 dietary study design elements based on the 2023 FDA guidance document and principles of precision, reproducibility, and validity from nutrition science literature.</div></div><div><h3>Results</h3><div>Dietary methodologies varied widely across trials. Fatty-acid oxidation disorder and methylmalonic/propionic acidemia studies used more structured dietary controls and multiple biomarkers/clinical assessments. In contrast, PKU trials relied heavily on blood phenylalanine levels, with limited assessment of dietary variability or adherence. Only a few of the included studies used validated dietary assessment methods, defined the range of acceptable dietary intake, or statistically assessed adherence to the dietary plan. Most failed to use objective tools to confirm compliance and instead relied on self-reported diet records. Newer trials showed improved adherence to FDA recommendations, but no study met all 14 elements.</div></div><div><h3>Conclusions</h3><div>Dietary assessments remain inconsistently addressed in IEM clinical trials, particularly in PKU. Failure to account for dietary variability reduces confidence in biomarker interpretation. Adopting validated dietary assessment methods and statistical modeling of intake variation can improve reproducibility and reduce confounding. Future trials should quantify acceptable dietary fluctuations and incorporate validated tools to ensure dietary rigor in biomarker-based drug efficacy studies.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"143 ","pages":"Article 113024"},"PeriodicalIF":3.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145701049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of obesity phenotypes from childhood to adolescence: Does diet quality in childhood matter? (PASE Study–Brazil)","authors":"Bruna Clemente Cota Ph.D. ,&nbsp;Mariana de Santis Filgueiras Ph.D. ,&nbsp;Leidjaira Lopes Juvanhol Ph.D. ,&nbsp;Patrícia Feliciano Pereira Ph.D. ,&nbsp;Juliana Farias de Novaes Ph.D.","doi":"10.1016/j.nut.2025.113027","DOIUrl":"10.1016/j.nut.2025.113027","url":null,"abstract":"<div><h3>Objectives</h3><div>Children with normal-weight obesity (NWO) are at increased risk of obesity, and poor diet quality can worsen this condition in the long term. This study aimed to analyze the influence of diet (via the NOVA classification and the Children’s Dietary Inflammatory Index [C-DII]) on the transition of obesity phenotypes from childhood to adolescence.</div></div><div><h3>Methods</h3><div>This was a cohort study the baseline of which was carried out on 378 children aged 8–9 y in Viçosa, Minas Gerais, Brazil, during 2015–2016. The same participants were re-evaluated during adolescence (15–18 y) between 2022 and 2024 (n = 277). Weight status was assessed against body mass index and age. Those with normal weight were classified as NWO (high body fat, assessed by dual-energy x-ray absorptiometry) or as normal-weight lean (NWL; without excess body fat). Food consumption was evaluated at baseline by three 24-h dietary recalls.</div></div><div><h3>Results</h3><div>The incidences of NWO and excess weight were 36.28% and 8.51%, respectively. Children with NWO presented a higher risk of excess weight in adolescence compared with NWL (relative risk = 2.89; 95% confidence interval: 1.20, 6.98). Children with a higher consumption of culinary ingredients and a lower consumption of processed foods, ultra-processed foods, and C-DII showed decreases in body fat (from NWO to NWL) during adolescence. Children with a higher consumption of processed foods showed increases in body fat (from NWL to NWO, and from NWO to excess weight) during adolescence.</div></div><div><h3>Conclusions</h3><div>Improved diet quality in childhood was associated with decreased body fat in adolescence, regardless of body mass index. These findings demonstrate the importance of reducing the consumption of processed and ultra-processed foods during childhood.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"143 ","pages":"Article 113027"},"PeriodicalIF":3.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145733785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of the Mediterranean diet on inflammation, quality of life, and mortality in autoimmune diseases: A systematic review featured in the Italian National Guidelines “La Dieta Mediterranea”","authors":"Vincenza Gianfredi M.D., Ph.D. ,&nbsp;Letizia Baldini M.D. ,&nbsp;Andrea Deledda Ph.D. ,&nbsp;Maria Michela Patruno M.D. ,&nbsp;Lucia Galluzzo M.A. ,&nbsp;Fernanda Velluzzi M.D. ,&nbsp;Domenico Rogoli M.Sc. ,&nbsp;Filippo Valoriani M.D. ,&nbsp;Nicola Veronese M.D. ,&nbsp;Massimo Volpe M.D. ,&nbsp;Stefania Maggi M.D. ,&nbsp;Federica Limongi Ph.D. ,&nbsp;Graziano Onder M.D., Ph.D. ,&nbsp;Stefano Ciriminna M.D. ,&nbsp;Marco Silano M.D. ,&nbsp;Michela Zanetti M.D. ,&nbsp;Daniele Nucci M.Sc., R.D.","doi":"10.1016/j.nut.2025.113026","DOIUrl":"10.1016/j.nut.2025.113026","url":null,"abstract":"<div><h3>Background</h3><div>Autoimmune diseases (ADs) are chronic inflammatory disorders with increasing global prevalence and substantial health and economic burden. The Mediterranean diet (MD), known for its anti-inflammatory and immunomodulatory properties, may offer complementary benefits in the management of these conditions.</div></div><div><h3>Methods</h3><div>This review was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 and Meta-analysis of Observational Studies in Epidemiology guidelines. A comprehensive search of PubMed/MEDLINE, Scopus, Embase, and Cochrane Library was performed up to February 28, 2024. Study quality was assessed using the Newcastle–Ottawa Scale or Risk of Bias tool, based on study design. The certainty of evidence was evaluated with the NUTRIGRADE approach. Eligible studies included studies evaluating MD adherence in individuals with ADs. Data were synthesized narratively and quantitatively.</div></div><div><h3>Results</h3><div>Fifteen studies (5 randomized controlled trials, 6 cross-sectional, 3 pre-post trials, and 1 cohort) involving patients with rheumatoid arthritis, Crohn’s disease, ulcerative rectocolitis, multiple sclerosis, and celiac disease were included. Higher MD adherence was associated with improved quality of life in patients with multiple sclerosis and celiac disease (moderate certainty), and to a lesser extent in rheumatoid arthritis (low certainty). Reductions in C-reactive protein were observed in some studies, but findings were inconsistent and of low certainty. One cohort study reported reduced mortality in patients with Crohn’s disease and inflammatory bowel disease. Limited evidence suggested favorable effects on gut microbiota and body composition.</div></div><div><h3>Conclusions</h3><div>Adherence to the MD may provide benefits in quality of life and inflammation-related outcomes among patients with ADs. However, the overall certainty of evidence remains limited.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"143 ","pages":"Article 113026"},"PeriodicalIF":3.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145733789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on “Birth weight of a child and the occurrence of overweight and obesity in preschool and school age birth weight and overweight in children”","authors":"Ge Rui MD,&nbsp;Shuxin Hu MD","doi":"10.1016/j.nut.2025.113019","DOIUrl":"10.1016/j.nut.2025.113019","url":null,"abstract":"","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"143 ","pages":"Article 113019"},"PeriodicalIF":3.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145701028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing body composition techniques against an adapted multicompartment model in individuals with excess body weight","authors":"Julia Montenegro PhD ,&nbsp;Jonathan P. Bennett PhD ,&nbsp;Camila L.P. Oliveira PhD ,&nbsp;Aloys Berg MD ,&nbsp;Arya M. Sharma MD ,&nbsp;Laurie Mereu MD ,&nbsp;John A. Shepherd PhD ,&nbsp;Mario Siervo PhD ,&nbsp;Jens Walter PhD ,&nbsp;Carla M. Prado PhD, RD","doi":"10.1016/j.nut.2025.113033","DOIUrl":"10.1016/j.nut.2025.113033","url":null,"abstract":"<div><h3>Objectives</h3><div>Accurate body composition assessment is critical for detecting individuals at increased health risk from excess adiposity; however, many measurement techniques lose accuracy in those with a higher body mass index (BMI). This study evaluated the accuracy of body composition techniques against a 4-compartment (4C) model in individuals with overweight or obesity.</div></div><div><h3>Methods</h3><div>N = 75 participants were categorized as having overweight (n = 56, BMI 25–29.9 kg/m²) or obesity (n = 19, BMI ≥30 kg/m²). Body composition was assessed by bioelectrical impedance analysis (BIA), air-displacement plethysmography (ADP), and dual-energy X-ray absorptiometry (DXA). An adapted 4C model used body mass, body volume (via ADP), bone mineral content (via DXA), and total body water (TBW, via BIA). Accuracy was assessed as mean differences (MD) ± standard deviation (comparator − 4C) and 95% limits of agreement (LoA).</div></div><div><h3>Results</h3><div>ADP demonstrated the smallest overall difference in body fat percentage (BF%; MD = 0.10% ± 1.70%, LoA [−3.23, 3.43], <em>P</em> = 0.620), but its accuracy reduced in individuals with obesity. Both BIA (MD = 1.73% ± 1.72%, LoA [−1.52, 4.98]) and DXA (MD = 1.86% ± 1.79%, LoA [−1.65, 5.37]) overestimated BF% (both <em>P</em> &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>Overall, ADP demonstrated the best accuracy, while DXA had the greatest differences compared to the 4C model. This may have resulted from TBW being overestimated by BIA, which would inflate 4C-derived fat-free mass. Although all methods demonstrated strong agreement for group-level BF%, a substantial individual-level variability (up to 5% error) highlights the need for caution when interpreting results in clinical or personalized assessment contexts in individuals with excess body weight.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"143 ","pages":"Article 113033"},"PeriodicalIF":3.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145878853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma proteomic profiles reveal immune modulation by immunonutrition in GI cancer","authors":"Semíramis Silva Santos Ph.D. ,&nbsp;Lucianna Auxi Teixeira Josino da Costa M.D., Ph.D. ,&nbsp;Tamara Soares de Oliveira Araripe R.N. ,&nbsp;Bárbara Danuta Lins Oliveira Reges R.N. ,&nbsp;Helena Maria de Albuquerque Ximenes Ph.D. ,&nbsp;Ana Cristina de Oliveira Monteiro Moreira Ph.D.","doi":"10.1016/j.nut.2025.113020","DOIUrl":"10.1016/j.nut.2025.113020","url":null,"abstract":"<div><h3>Background</h3><div>Gastrointestinal (GI) cancer patients undergoing surgery often face immunosuppression, increasing postoperative risk. Immunomodulatory enteral nutrition (IEN) may enhance immune function and recovery, but mechanisms remain unclear. This study compared plasma proteomic profiles of patients receiving IEN versus standard enteral nutrition (SEN) to explore pathways linked to outcomes.</div></div><div><h3>Methods</h3><div>This analysis extended a previously published randomized clinical trial in GI cancer patients who received SEN or IEN postoperatively, with 50 patients in each group. The IEN was rich in arginine, nucleotides, vitamin B12, chloride, vitamin C, selenium, chromium, and molybdenum. Plasma samples were analyzed using mass spectrometry–based proteomics (MassLynx v4.1 and Progenesis v4.1). Proteins consistently detected across replicates (database search <em>P</em> &lt; 0.05) were identified. Clinical outcomes, including complications and biochemical markers, were integrated with proteomic findings to interpret biological mechanisms.</div></div><div><h3>Results</h3><div>Distinct proteomic profiles were observed. The IEN group showed higher levels of complement proteins (C3, C5, C9), inter-alpha-trypsin inhibitor heavy chain H2, pregnancy zone protein, immunoglobulins, and apolipoproteins—proteins linked to immune modulation, tissue repair, and inflammation control. The SEN group displayed elevated acute-phase proteins and coagulation factors, including fibrinogen and serum amyloid A-4, consistent with a pro-inflammatory, hypercoagulable state. These differences paralleled clinical results, with the IEN group experiencing fewer complications and improved albumin/globulin ratios.</div></div><div><h3>Conclusions</h3><div>This exploratory study suggests that immunonutrition may modulate complement activation and immune pathways, supporting better postoperative outcomes in GI cancer patients. The proteomic profile provides evidence that supports a mechanistic hypothesis underlying the observed clinical benefits. Future quantitative proteomics with larger cohorts is warranted to validate these findings and optimize perioperative nutrition strategies.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"143 ","pages":"Article 113020"},"PeriodicalIF":3.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145883906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on “Nutritional outcomes in people with cystic fibrosis receiving elexacaftor/tezacaftor/ivacaftor: A 24-month real-world study”","authors":"S. Dhanya Dedeepya MD,&nbsp;Vaishali Goel PhD,&nbsp;Nivedita Nikhil Desai MD","doi":"10.1016/j.nut.2025.113048","DOIUrl":"10.1016/j.nut.2025.113048","url":null,"abstract":"","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"143 ","pages":"Article 113048"},"PeriodicalIF":3.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145844117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}