Nutrition最新文献

{"title":"Low variability of resting metabolic rate among early, middle, and late achievers of steady state suggests a shortened indirect calorimetry protocol for young children","authors":"Adeline Pretorius Ph.D. ,&nbsp;Paola S. Wood Ph.D. ,&nbsp;Piet J. Becker Ph.D. ,&nbsp;Friedeburg A.M. Wenhold Ph.D.","doi":"10.1016/j.nut.2025.112779","DOIUrl":"10.1016/j.nut.2025.112779","url":null,"abstract":"<div><h3>Objective</h3><div>Standardized protocols for measuring resting metabolic rate (RMR; kJ/d) in children, using indirect calorimetry (IC), are lacking. In this cross-sectional, observational study we aimed to determine, in a diverse group of children, variability of RMR-associated measurements after achieving steady state (SS) with a shortened IC protocol. RMR of 120 conveniently sampled healthy Southern African children 6 to 9 years (60 black [32 girls], 60 white [37 girls]) was measured via IC (Quark RMR, Cosmed).</div></div><div><h3>Methods</h3><div>Measurements, without a prior rest period, continued for 15 to 20 minutes. Participants were categorized according to time when machine-generated SS was achieved: early achievers &lt;5 minutes, middle achievers ≥5 and &lt;10 minutes, late achievers ≥10 minutes. Readings before achieving SS were eliminated. Intra-individual percentage coefficient of variation of the mean RMR (kJ/d), VCO₂ (mL/min), VO₂ (mL/min), and respiratory quotient (VCO₂/VO₂) was determined for each SS category for the remaining measurement period.</div></div><div><h3>Results</h3><div>For 113 (94%) participants, usable data were obtained. Mean (min; max) time to reach SS was 5.7 minutes (0.0; 16.2). Nineteen (17%; 6 black; 10 girls [3 black]) did not achieve SS, with no significant difference between sexes (<em>P</em> = 0.290). Significantly (<em>P</em> = 0.048) more white (12%) than black (5%) participants did not achieve SS. Forty-seven (50%) were early, 29 (31%) middle, and 18 (19%) late achievers of SS. There was no significant difference in the sample distribution of SS categories between sexes (<em>P</em> = 0.955) and race/ethnicity categories (<em>P</em> = 9.758).</div></div><div><h3>Conclusions</h3><div>After achieving SS, percentage coefficient of variation for all RMR-related variables remained ≤2.89%, well below the recommended &lt;5% to 10% for adults. A shortened IC protocol can be considered for diverse groups of 6- to 9-year-old children.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"136 ","pages":"Article 112779"},"PeriodicalIF":3.2,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143899182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modulation of snack foods: An approach to overcome hidden hunger in children","authors":"Sana Manzoor ,&nbsp;Ammar B. Altemim ,&nbsp;Allah Rakha ,&nbsp;Hina Rasheed ,&nbsp;Muhammad Shaffay Ali Khan ,&nbsp;Seemal Munir ,&nbsp;Zuhaib F. Bhat ,&nbsp;Rana Muhammad Aadil","doi":"10.1016/j.nut.2025.112777","DOIUrl":"10.1016/j.nut.2025.112777","url":null,"abstract":"<div><div>The global snack foods market had grown to 585 billion USD by 2022. Consumption of snacks has gained attention at a commercial level since they are liked by people of all ages, including millennials and elderly people. An increasing trend in snacking provides a potential opportunity for delivering micronutrients to minimize hidden hunger throughout the world. Various strategies are proposed in this review for modifying these snacks to improve snacking. The practical implications, including methodologies and approaches of such strategies, have also been summarized. The raw materials used for snack development can be biofortified for additional mineral content. By-products of fruits and vegetables can be used as ingredients and nutrient sources in the food industry. Organic salts, industrial fortificants, and nutritive substitutes can be used in extrusion processing as an enrichment method. Snacks can also be reformulated to contain more nutrients. Such strategies could greatly improve not only individual health but also the global market.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"135 ","pages":"Article 112777"},"PeriodicalIF":3.2,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143878496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of 8-hour time-restricted eating combined with different dietary patterns on body composition, lipid metabolism, and oxidative stress in healthy adults: An exploratory study from an RCT","authors":"Xinzheng Liang MD ,&nbsp;Yuanchen Zhou MD ,&nbsp;Youjia Kong MS ,&nbsp;Jixiang Liu MD ,&nbsp;Kaimin Li MD ,&nbsp;Lijun Xue MD ,&nbsp;Shukun Yao MD, PhD","doi":"10.1016/j.nut.2025.112776","DOIUrl":"10.1016/j.nut.2025.112776","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate the effectiveness of a 4-week intervention of time-restricted eating (TRE) alone or in combination with an elimination of ultra-processed foods or vegetarian diet, on body composition, lipid metabolism, and oxidative stress.</div></div><div><h3>Methods</h3><div>This was a randomized controlled trial including 70 participants comparing three diet groups maintained for a 4-week period: A, TRE alone; B, TRE with elimination of ultra-processed foods; and C, TRE with a vegetarian diet. Per-protocol analyses of body composition, plasma lipid levels, and oxidative stress markers were performed.</div></div><div><h3>Results</h3><div>Compared to baseline, Group B significantly reduced weight (<em>P</em> = 0.02), body mass index, waist and hip circumference, as well as fat ratio, total cholesterol, 4-hydroxynonenal an 8-Iso prostaglandin F 2α (all <em>P</em> &lt; 0.05). Group B also increased high-density lipoprotein cholesterol (<em>P</em> &lt; 0.05) and catalase (<em>P</em> = 0.002). Compared to Group A, Group B was more effective in decreasing body mass index (Δ: –0.1 ± 0.7 vs. –0.2 ± 0.3, respectively, <em>P</em> = 0.041) and waist circumference (Δ: –1.1 ± 4.0 vs. –3.5 ± 4.4, <em>P</em> &lt; 0.001). Compared to Group A and B, the increase in superoxide dismutase (Δ: 12.74 ± 8.34, <em>P</em> &lt; 0.05) and glutathione (Δ: 0.63 ± 0.40, <em>P</em> &lt; 0.05) was significantly greater for Group C. Group C also produced a greater decrease in malondialdehyde (Δ: –0.79 ± 0.28) than the Group A (Δ: –0.32 ± 0.51, <em>P</em> &lt; 0.001) and Group B (Δ: –0.20 ± 0.68, <em>P</em> &lt; 0.001) diets.</div></div><div><h3>Conclusions</h3><div>Consumption of ultra-processed foods can increase body composition and lipid profile, despite TRE. A vegetarian diet in combination with TRE is effective in reducing oxidative stress injury.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"136 ","pages":"Article 112776"},"PeriodicalIF":3.2,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143890998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improved appendicular muscle strength predicts lower mortality in patients with heart failure","authors":"Takumi Noda P.T., Ph.D. ,&nbsp;Kentaro Kamiya P.T., Ph.D. ,&nbsp;Nobuaki Hamazaki P.T., Ph.D. ,&nbsp;Takashi Miki P.T., M.Sc. ,&nbsp;Kohei Nozaki P.T., Ph.D. ,&nbsp;Takafumi Ichikawa P.T. ,&nbsp;Masashi Yamashita P.T., Ph.D. ,&nbsp;Shota Uchida P.T., Ph.D. ,&nbsp;Kensuke Ueno P.T., Ph.D. ,&nbsp;Emi Maekawa M.D., Ph.D. ,&nbsp;Tasuku Terada C.E.P., Ph.D. ,&nbsp;Jennifer L. Reed R.Kin., Ph.D. ,&nbsp;Minako Yamaoka-Tojo M.D., Ph.D. ,&nbsp;Atsuhiko Matsunaga P.T., Ph.D. ,&nbsp;Junya Ako M.D., Ph.D.","doi":"10.1016/j.nut.2025.112774","DOIUrl":"10.1016/j.nut.2025.112774","url":null,"abstract":"<div><h3>Background</h3><div>A decrease in general muscle strength is associated with a poor prognosis and lower physical function in patients with heart failure (HF). We examined whether improved appendicular muscle weakness (dynapenia) conditions would predict a better prognosis and improved physical functions in patients with HF.</div></div><div><h3>Methods</h3><div>Handgrip and leg strength were assessed before discharge (baseline) and after outpatient cardiac rehabilitation (CR) (follow-up), based on which patients were divided into four dynapenia conditions: non-dynapenia at baseline/follow-up, dynapenia at baseline/non-dynapenia at follow-up, non-dynapenia at baseline/dynapenia at follow-up, and dynapenia at baseline/follow-up. Cox regression and mixed-effects analyses were performed to examine associations between changes in the dynapenia condition and all-cause mortality and physical functions (6-minute walking distance and gait speed).</div></div><div><h3>Results</h3><div>Of 607 patients included in the analyses (median age 70 years, 64% male), 92 patients died during the follow-up period (median 2.81 years). The dynapenia at baseline/follow-up group (adjusted hazard ratio [aHR]: 1.936, 95% confidence interval [CI]: 1.086–3.451) and non-dynapenia at baseline/dynapenia at follow-up group (aHR: 2.442, 95% CI: 1.032–5.766) had higher mortality rates compared to the non-dynapenia at baseline/follow-up group. The mortality risk was not different between the group with dynapenia at baseline/non-dynapenia at follow-up (aHR: 1.270, 95% CI: 0.670–2.409) and the group with non-dynapenia at baseline/follow-up. Improved dynapenia conditions were associated with increased 6-minute walking distance (<em>p</em> = 0.004) but not significantly associated with gait speed (<em>p</em> = 0.173).</div></div><div><h3>Conclusions</h3><div>Dynapenia following CR is associated with a higher risk of mortality and lower exercise capacity in patients with HF.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"136 ","pages":"Article 112774"},"PeriodicalIF":3.2,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143890999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A randomized controlled trial study using WhatsApp-delivered transtheoretical model–based intervention to promote healthy eating habits and anthropometric measurements for male firefighters","authors":"Winnie Wing Man Ng DHSc ,&nbsp;Kin Cheung PhD ,&nbsp;Maria Shuk Yu Hung SDHSc ,&nbsp;Ki Lui PhD","doi":"10.1016/j.nut.2025.112764","DOIUrl":"10.1016/j.nut.2025.112764","url":null,"abstract":"<div><h3>Background</h3><div>Fruit and vegetables (F&amp;V) consumption is critical to preventing non-communicable diseases such as overweight and obesity. However, many people, including firefighters, focus on physical exercise to strengthen their physical fitness but ignore healthy eating, especially F&amp;V consumption. The aim of this study was to investigate the association between a stage-matched health promotion program delivered through WhatsApp and the stage of change for F&amp;V intake and its influence on anthropometric measurements.</div></div><div><h3>Methods</h3><div>Forty-eight firefighters were randomly assigned to either an intervention (health promotion pamphlet and stage-matched teaching materials through WhatsApp) or active control (health promotion pamphlet) group. Twenty-three were assigned to the intervention group and 25 to the active control group.</div></div><div><h3>Results</h3><div>Significant differences (<em>P &lt;</em> 0.05) were found within the group comparison at the stage of change. More than 60 and 44 percent of firefighters in intervention and active control groups, repectively, were promoted to the “Action” and “Maintenance” stages 6 months after the completion of the intervention. The mixed-effects model results indicated a significant interaction between the two groups across the three time points with regard to the number of fruits consumed (<em>P</em> = 0.0022). This observation suggests that the intervention had a varying effect on the number of fruits ingested over time compared to the control group. Significant differences in body weight, body mass indexes, and waist circumference were observed within both groups (<em>P</em> &lt; 0.05).</div></div><div><h3>Conclusions</h3><div>Stage-matched interventions based on the transtheoretical model delivered through WhatsApp successfully promoted F&amp;V consumption and improved anthropometric measurements among firefighters.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"136 ","pages":"Article 112764"},"PeriodicalIF":3.2,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143878771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healthy lifestyle and sustainable behaviors: a proposal for the food pyramid in the Brazilian context","authors":"Sonia Tucunduva Philippi Ph.D., R.D. ,&nbsp;Rita de Cássia Aquino Ph.D., R.D. ,&nbsp;Elizabeth Aparecida Ferraz da Silva Torres Ph.D. ,&nbsp;Ana Carolina Barco Leme Ph.D., R.D.","doi":"10.1016/j.nut.2025.112771","DOIUrl":"10.1016/j.nut.2025.112771","url":null,"abstract":"<div><h3>Objectives</h3><div>Food graphics are visual representations that help many stakeholders follow nutrition recommendations, improve their lifestyle, and follow sustainable behaviors. There is a paucity of recent evidence on the use of food graphics, and this review provides the foundation for adapting a food graphic for the Brazilian context.</div></div><div><h3>Methods</h3><div>A narrative review of the literature on food graphics, healthy eating, and sustainability was performed. The official Food Agriculture Organization/United Nations website was used to identify food guides the respective graphics/icons, key messages, and food groups.</div></div><div><h3>Results</h3><div>Many countries use food graphics to educate people on healthy eating, lifestyle, and sustainable behaviors. In the food guides we analyzed, the most representative food graphics included circular and hierarchical types. Hierarchical types were represented by a variety of names, with pyramids or triangles the most common forms. Core recommendations on healthy food choices were based on the WHO and EAT-Lancet. Seven food groups were identified according to the country's socio-cultural and economic context. Additionally, water and other sugar-free beverages, unconventional food plants, and physical activity were included in the graphic. The majority of countries’ food graphics named each food group according to the main food. For all countries improvements in lifestyle behaviors was the key message, while one quarter of countries included sustainability messages.</div></div><div><h3>Conclusions</h3><div>Food graphics, such as pyramids, represent an important tool to assist all stakeholders to follow dietary recommendations. These graphics provide the information needed to recognize and put into practice individual and social behaviors that promote the improved individual and community health of future generations.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"135 ","pages":"Article 112771"},"PeriodicalIF":3.2,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143855001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between myostatin, musclin, nutritional status, and functionality in older Colombian community-dwelling adults: a cross-sectional study","authors":"Nancy Marulanda-Díaz M.Sc. ,&nbsp;Alejandro Estrada-Restrepo M.Sc. ,&nbsp;Andrés F. Milán M.Sc. ,&nbsp;Raul Narvaez-Sanchez Ph.D. ,&nbsp;Juan C. Calderón Ph.D. ,&nbsp;Nubia A. Giraldo-Giraldo M.Sc.","doi":"10.1016/j.nut.2025.112767","DOIUrl":"10.1016/j.nut.2025.112767","url":null,"abstract":"<div><h3>Objectives</h3><div>Aging-associated body composition changes lead to a decrease in muscle mass and strength, affecting the functionality of older adults. Myostatin and musclin are myokines that regulate muscle metabolism and may modulate muscle changes during aging. Our objective was to determine the relationship between myostatin, musclin, and nutritional status with physical functionality in older adults.</div></div><div><h3>Methods</h3><div>This was a cross-sectional study of a subsample of a stratified random sampling population survey in community-dwelling 60–90-year-old adults of both sexes. Serum myostatin and musclin concentrations were measured using MILLIPLEX technology (Merck Millipore, USA). Trained personnel recorded body mass index (BMI), and waist (WC), calf (CC), and arm (AC) circumferences as indicators of nutritional status. Functionality tests included handgrip strength (GS), walking speed (WS), and Advanced Activities of Daily Living.</div></div><div><h3>Results</h3><div>Of 101 participants, 55.4% were women, 56.4% were between 60 and 69 years old, 53.5% had abdominal obesity, 23.8% had dynapenia, and 33.7% had low WS. Neither myostatin nor musclin showed significant changes from 60 to 90 years. In a multiple lineal regression model, myostatin showed an inverse correlation with BMI, CC, and AC in men (<em>P</em> &lt; 0.05) but did not explain GS or WS. In a similar analysis, musclin and WC showed an inverse correlation with GS (<em>P</em> &lt; 0.05). Moreover, myostatin was lower in the more physically active men (<em>P</em> &lt; 0.05) but musclin did not show any relationship with the Advanced Activities of Daily Living scale.</div></div><div><h3>Conclusions</h3><div>Myostatin and musclin do not decrease with aging and are associated with nutritional and metabolic status. Musclin is associated with dynapenic obesity in older adults.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"135 ","pages":"Article 112767"},"PeriodicalIF":3.2,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143859810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between phase angle and body composition: new equations to predict fat mass and skeletal muscle mass","authors":"Daniel Rojano-Ortega ,&nbsp;Antonio Jesús Berral-Aguilar ,&nbsp;Heliodoro Moya-Amaya ,&nbsp;Antonio Molina-López ,&nbsp;Francisco José Berral-de la Rosa","doi":"10.1016/j.nut.2025.112772","DOIUrl":"10.1016/j.nut.2025.112772","url":null,"abstract":"<div><h3>Objective</h3><div>The aim of this cross-sectional study was to develop new regression equations for estimating fat mass (FM) and skeletal muscle mass (SMM) in a heterogeneous Caucasian population, using the phase angle (PhA) as a bioelectrical parameter and DXA as the reference method. We also aimed to cross-validate the new equations, and to compare them with the manufacturers’ equations.</div></div><div><h3>Methods</h3><div>The 212 healthy Caucasian participants aged 20–65 years were randomly distributed into two groups: development group (n = 141) and validation group (n = 71). Bioelectrical parameters were obtained with a 50 kHz foot-to-hand phase-sensitive body composition analyzer. The new FM percentage (FM%) and SMM percentage (SMM%) equations were developed by performing multiple forward regression analyses. Agreement between DXA and the different equations was assessed by mean differences, coefficient of determination, standard error of the estimate (SEE), concordance correlation coefficient (CCC), and Bland–Altman plots.</div></div><div><h3>Results</h3><div>The proposed equations explained 89.2% of the variance in the DXA-derived FM% and 91.8% in the DXA-derived SMM%, with low random errors (SEE = 3.04% and 1.92%, respectively), and a very strong agreement (CCC = 0.93 and 0.94, respectively). In addition, they demonstrated no fixed bias and a relatively low individual variability. However, the manufacturer's equations described a lower percentage of the variance, with higher random errors, obtained fixed bias of -5.77% for FM% and 4.91% for SMM%, as well as higher individual variability.</div></div><div><h3>Conclusions</h3><div>The new regression equations, which include the PhA as a bioelectrical parameter, can accurately predict DXA-derived FM% and SMM% in a heterogeneous Caucasian population, and are better options than the manufacturer's equations.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"135 ","pages":"Article 112772"},"PeriodicalIF":3.2,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of integrative telehealth-based nutrition care with and without oral nutritional supplements in patients with liver and colorectal cancer: A randomized controlled trial","authors":"Wei-Chun Chang M.S. ,&nbsp;Ming-Shun Wu M.D. ,&nbsp;Yi-Hsiu Chen M.S. ,&nbsp;Suh-Ching Yang Ph.D.","doi":"10.1016/j.nut.2025.112768","DOIUrl":"10.1016/j.nut.2025.112768","url":null,"abstract":"<div><h3>Objectives</h3><div>This study investigated the effects of post-discharge integrative telehealth-based nutritional care alone versus post-discharge integrative telehealth-based nutritional care combined with high-calorie/high-protein oral nutritional supplements (HCHP-ONS) on the nutritional status and quality of life in patients with hepatocellular carcinoma (HCC) or colorectal cancer (CRC) at risk of malnutrition.</div></div><div><h3>Methods</h3><div>We recruited HCC or CRC patients who were at moderate to high risk of malnutrition, defined as a score of 4–9 on the abridged Patient-Generated Subjective Global Assessment (aPG-SGA), and randomly assigned them to either a telehealth nutritional care-control group (C group) or a telehealth nutritional care combined with HCHP-ONS group (C+O group) for a 3-month intervention. In group C, a dietitian provided monthly telehealth-based nutritional assessments and guidance through a mobile application (LINE) or phone calls. In the C+O group, in addition to telehealth-based nutritional assessments and guidance, patients received a daily can of HCHP-ONS, which provided 425 kcal and 19.1 g of protein per serving. Blood tests, anthropometric indicators, the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) and a nutritional status assessment were conducted monthly.</div></div><div><h3>Results</h3><div>Results showed that the C+O group had significantly reduced malnutrition risk scores at the 1^st, 2^nd, and 3^rd months. By the 3^rd month, the C+O group showed significant improvement in the Prognostic Nutritional Index (PNI), and notable improvements in diarrhea and respiratory distress scores.</div></div><div><h3>Conclusions</h3><div>In patients with HCC and CRC who were at risk of malnutrition, integrative telehealth-based nutritional care via LINE or phone calls effectively reduced malnutrition risk, maintained PNI, and supported quality of life (QOL). The addition of HCHP-ONS further enhanced nutritional outcomes, leading to greater improvements in PNI, diarrhea, and dyspnea by the 3^rd month.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"135 ","pages":"Article 112768"},"PeriodicalIF":3.2,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The mediating role of perceived social isolation in feeding methods and depression among patients with dysphagia after ischemic stroke: A multicenter study","authors":"Hongji Zeng M.Med. ,&nbsp;Jing Zeng B.S. ,&nbsp;Weijia Zhao M.Med. ,&nbsp;Yuzhen Qin Ph.D. ,&nbsp;Changming Wen Ph.D. ,&nbsp;Xi Zeng Ph.D.","doi":"10.1016/j.nut.2025.112769","DOIUrl":"10.1016/j.nut.2025.112769","url":null,"abstract":"<div><h3>Background</h3><div>Feeding methods may influence post stroke depression. Perceived social isolation may mediate this underlying mechanism. In this study we explored the effects of perceived social isolation on the relationship between feeding methods and post stroke depression.</div></div><div><h3>Methods</h3><div>This observational study was conducted between 2022 and 2024. The subjects were ischemic stroke survivors with dysphagia. Information was collected, including 1) depression levels (Patient Health Questionnaire-9 items [PHQ-9]), 2) demographic characteristics, 3) clinical conditions, 4) treatment details, and 5) perceived social isolation. After matching the baseline and treatment-related variables, a mediation model was used to analyze the relationship among perceived social isolation, feeding methods, and depression levels.</div></div><div><h3>Results</h3><div>There were 2764 participants (44.54% using Nasogastric Tube feeding [NGT]). Before matching, the PHQ-9 score for all participants on day 10 was significantly lower than that at admission (<em>P</em> &lt; 0.001). After matching confounding factors, the PHQ-9 score on day 10 for the Intermittent Oro-Esophageal tube feeding (IOE) users was significantly lower than that of the NGT users [(7.03 ± 2.52) versus (9.25 ± 5.55), n1 = n2 = 800, <em>P</em> &lt; 0.001]. The mediation model showed that 1) compared to NGT, IOE can cause significantly lower perceived social isolation on day 10 (effect = 5.808, <em>P</em> &lt; 0.001); 2) compared to NGT, IOE can significantly lower depression levels on day 10 (effect = 0.180, <em>P</em> &lt; 0.001); and (3) perceived social isolation showed partial mediating effects, and the proportion of the mediation effect was 47.19% (1.046/2.218, <em>P</em> &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>Compared to NGT, IOE can significantly improve post stroke depression levels. Perceived social isolation mediated the relationship between feeding methods and post stroke depression.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"135 ","pages":"Article 112769"},"PeriodicalIF":3.2,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143806851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}