Nutrition最新文献

{"title":"Low serum albumin and severe undernutrition in subjects with diabetes and weight loss","authors":"Lila Rami Arab M.D., Ph.D. ,&nbsp;Annie M. Bérard M.D., Ph.D. ,&nbsp;Geneviève Lacape M.D., Ph.D. ,&nbsp;Marie-Amélie Barbet-Massin M.D. ,&nbsp;Laurence Blanco M.D. ,&nbsp;Ninon Foussard M.D., Ph.D. ,&nbsp;Florian Poullenot M.D. ,&nbsp;Alice Larroumet M.D. ,&nbsp;Kamel Mohammedi M.D., Ph.D. ,&nbsp;Michel Montaudon M.D., Ph.D. ,&nbsp;Hervé Trillaud M.D., Ph.D. ,&nbsp;Vincent Rigalleau M.D., Ph.D.","doi":"10.1016/j.nut.2025.112883","DOIUrl":"10.1016/j.nut.2025.112883","url":null,"abstract":"<div><div>Hypoalbuminemia predicts adverse outcomes in subjects with diabetes. We investigated how it relates to type, duration, control, and diabetic complications. Albumin levels were measured in subjects hospitalized for uncontrolled diabetes and unexpected weight loss in our diabetology ward from 2010 to 2019. All underwent a clinical interview and examination with a CT-scanner and were checked for chronic diabetic complications. By multivariate binary regression, we analyzed the determinants of low serum albumin (&lt;38 g/L) or severe undernutrition (weight loss and albumin &lt;30 g/L). The 334 subjects were in the majority men (60.5%), 59 ± 12 y old. They had recently lost –3.8 kg/3 mo (IQR: –5.0 to –1.5). The diabetes was mainly type 2: 78.7% (type 1: 15.3%, type 3, pancreatic: 6.0%), with means of 5 y duration (IQR: 0–13) and poorly controlled hemoglobin A1c (HbA1c) 10.5% ± 2.8%. The mean albuminemia was 37.6 ± 5.1 g/L (median: 38.5 g/L, IQR: 34.8–41.1). Low serum albumin was present in 151 subjects (45.2%), related to age, female sex, hepatic cirrhosis, C-reactive protein, HbA1c, and a high duration of diabetes. Severe undernutrition was present in 26 subjects (7.8%), also related to C-reactive protein, HbA1c, a high duration of diabetes, and pancreatic diabetes. The albumin levels were significantly lower (–2 g/L) both in subjects with diabetic retinopathy and neuropathy. After adjustment for age, sex, duration of diabetes, and HbA1c, a low serum albumin was related to neuropathy. In subjects with diabetes hospitalized for weight loss, a low serum albumin and severe undernutrition relate to poorly controlled and lengthy diabetes, especially pancreatic, and with diabetic neuropathy.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"139 ","pages":"Article 112883"},"PeriodicalIF":3.2,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144570547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Probiotic modulation of duodenal iron handling under high-fat diets: A mechanistically informed commentary.","authors":"Gokhan Koker","doi":"10.1016/j.nut.2025.112881","DOIUrl":"https://doi.org/10.1016/j.nut.2025.112881","url":null,"abstract":"","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":" ","pages":"112881"},"PeriodicalIF":3.2,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144619487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developing and assessing the effectiveness of a participatory, nutritional, and physical activity intervention on muscle function and quality of life among older adults with overnutrition in nursing homes—The IFEBO cluster randomized control trial","authors":"Tenna Christoffersen PhD ,&nbsp;Anne Marie Beck PhD ,&nbsp;Anja Weirsøe Dynesen PhD ,&nbsp;Janne Kunchel Lorenzen PhD ,&nbsp;Anders Reenberg Andersen PhD ,&nbsp;Margit Dall Aaslyng PhD ,&nbsp;Inge Tetens PhD","doi":"10.1016/j.nut.2025.112876","DOIUrl":"10.1016/j.nut.2025.112876","url":null,"abstract":"<div><h3>Background</h3><div>Overnutrition, defined as overweight and obesity, is a growing concern among older adults, increasing the risk of comorbidity, disabilities, and mortality. However, the optimal management of overnutrition in this population remains unclear.</div></div><div><h3>Purpose</h3><div>The aim is to develop and assess the effectiveness of a nutritional and physical activity intervention on muscle function and quality of life (QoL) among older adults with overnutrition in nursing homes (NHs).</div></div><div><h3>Methods</h3><div>A 12-mo cluster randomized participatory trial was conducted in six Danish NHs. The NHs were assigned following a 1:1 allocation ratio for control and intervention. Using the Plan-Do-Study-Act model, intervention components were participatorily developed over the first 6 mo and implemented over the remaining 6 mo. Muscle strength was measured via hand grip strength and a 30-second chair stand test. The Adult Social Care Outcomes Toolkit assessed the care-related QoL. Mixed-effects models analyses were used to evaluate the intervention effects.</div></div><div><h3>Results</h3><div>Ninety-three residents participated; 59% were overnourished. The intervention included daily/weekly physical and social activities, protein-rich bread, “Snack-on-Wheels,” systematic weighing, nutritional tasks for trained staff, and communication standards. Hand grip strength improved among men across weight statuses in the intervention group compared to the control group (<em>P</em> = 0.039). QoL was maintained in the overweight group, whereas it improved in the normal weight group (<em>P</em> = 0.019), with significant gains in social participation for both subgroups (<em>P</em> = 0.026).</div></div><div><h3>Conclusions</h3><div>Participatorily developed nutrition and physical activity interventions can improve all NH residents’ physical function and well-being.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"139 ","pages":"Article 112876"},"PeriodicalIF":3.2,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144605229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of clinical activities of dietitians-nutritionists in 13 countries using the Professional weighted Activities Score (PwAS): A proposed tool for assessing performance in hospital settings based on activity Prioritization","authors":"Solange Parra-Soto ,&nbsp;Samuel Durán-Aguero ,&nbsp;Mirta Crovetto ,&nbsp;Frank Carrera-Gil ,&nbsp;Tannia Valeria Carpio-Arias ,&nbsp;Edna J Nava González ,&nbsp;Saby Mauricio-Alza ,&nbsp;Leslie Landaeta-Díaz ,&nbsp;Melissa Miranda-Durán ,&nbsp;Jhon Jairo Bejarano-Roncancio ,&nbsp;Sonia Ivankovich Guillén ,&nbsp;Sheila Cerezo-Ríos ,&nbsp;Karla Cordón-Arrivillaga ,&nbsp;Beatriz Núñez-Martínez ,&nbsp;Gloria Maricela Morales-Morales ,&nbsp;Eliana Romina Meza Miranda ,&nbsp;Diego Pavez ,&nbsp;Marisa Canicoba ,&nbsp;Alfonsina Ortiz-Fiorito","doi":"10.1016/j.nut.2025.112877","DOIUrl":"10.1016/j.nut.2025.112877","url":null,"abstract":"<div><div>Objectives: In Latin America, clinical dietitian-nutritionists (DNs) play a crucial role in addressing the rising prevalence of chronic disease and malnutrition within hospitals. However, there is a lack of a common tool to evaluate prioritization activities among nutrition professionals. Having a reliable tool could help standardize and enhance the quality clinical nutrition practice in Latin America, as well as enable optimal utilization of the DN skills, ultimately reducing job burnout and improving quality of care. This study aimed to: 1) develop a Professional Weighted Activities Score (PwAS) to assess the professional activities of DNs in hospital settings according to task prioritization; and 2) apply the new scoring system to a previously collected sample of Latin American DNs.</div></div><div><h3>Methods</h3><div>The PwAS tool was developed using the criteria of a panel of experts from all participating countries. A multicentric and cross-sectional study was conducted among 1222 clinical DNs from 13 Latin American countries to identify their professional activities in public and private health care facilities. The survey comprised 30 questions related to clinical nutrition tasks, with responses weighted according to the priority assigned by an expert panel.</div></div><div><h3>Results</h3><div>A PwAS was developed encompassing 19 activities performed by clinical DN, each assigned a prioritization score by a panel of experts in clinical nutrition. The scoring spectrum ranged from 0 to 100, reflecting the variability in DN engagement with their professional activities. The analysis revealed significant differences in the professional activities of DNs across various countries. Guatemala, Paraguay, and Colombia achieved the highest scores, while Costa Rica, Peru, and Uruguay recorded the lowest. Factors positively associated with higher PwAS scores included greater years of experience and multiple specializations. In contrast, working in low-complexity facilities and facing barriers to task performance were negatively correlated with the PwAS.</div></div><div><h3>Conclusions</h3><div>The significant variation observed in clinical nutrition practices across countries underscores the need for studies to identify underlying causes and develop standardization. The PwAS tool could serve as a valuable resource for hospital administrators seeking to optimize staffing and enhance the quality of nutritional care within Latin American health care systems.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"139 ","pages":"Article 112877"},"PeriodicalIF":3.2,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144597030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of different nutritional interventions on abdominal adiposity components and metabolic parameters","authors":"Camila Lima Chagas ,&nbsp;Cláudia Porto Sabino Pinho ,&nbsp;Nadja Fernandes da Silva ,&nbsp;Isa Galvão Rodrigues ,&nbsp;Gabriela Maria Pereira Floro Arcoverde ,&nbsp;Poliana Coelho Cabral ,&nbsp;Ilma Kruze Grande de Arruda","doi":"10.1016/j.nut.2025.112874","DOIUrl":"10.1016/j.nut.2025.112874","url":null,"abstract":"<div><h3>Objectives</h3><div>To measure the effects of different nutritional interventions on abdominal adipose components and metabolic parameters.</div></div><div><h3>Methods</h3><div>A randomized clinical trial.We included individuals aged 20 years and older with excess weight (i.e., body mass index, ≥BMI, of 25 kg/m² for adults; and ≥ 27 kg/m² for older adults). Participants were stratified into three intervention groups: Group 1: Caloric restriction with balanced macronutrient distribution. Group 2: Caloric and carbohydrate restrictions. Group 3: Caloric and lipid restrictions. An active control group (Group 4) received nutritional counseling only. Visceral and subcutaneous adiposity (VAT and SAT) The compartments were measured using ultrasound. Anthropometric, clinical, sociodemographic, and behavioral data were included in the predictive models.</div></div><div><h3>Results</h3><div>A total of 105 participants completed the study. At baseline (T0), all groups were comparable in physical activity status, BMI, waist circumference (WC), VAT, and SAT. Group 2 reported a higher caloric intake, compared to Groups 1 and 3 (<em>P</em> = 0.020). Postintervention, all groups demonstrated reductions in weight, BMI, and WC (<em>P</em> &lt; 0.05). Only Groups 1 and 2 achieved significant reductions in VAT (<em>P</em> &lt; 0.05), while no significant changes were observed in SAT (<em>P</em> &gt; 0.05). VAT reduction varied from 0.6% (control group) to 9.0% (Group 2), although differences between groups were not significant (<em>P</em> = 0.202). Serum glucose and lipid levels were similar across all groups (T0, <em>P</em> &gt; 0.05), and no intervention changed these metabolic parameters (<em>P</em> &gt; 0.05).</div></div><div><h3>Conclusion</h3><div>After three months, we observed minimal differences in weight loss across the different nutritional strategies, suggesting that nutritional counseling and/or specific dietary protocols can effectively promote weight reduction.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"139 ","pages":"Article 112874"},"PeriodicalIF":3.2,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144534715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between preoperative nutritional status with postoperative IL-10 and neopterin in gynecologic oncology patients","authors":"Fazıl Avcı M.D. ,&nbsp;Ahmet Bilgi M.D. ,&nbsp;Ayse Gül Kebapcılar M.D. ,&nbsp;Mehmet Kulhan M.D. ,&nbsp;Fikret Akyürek M.D. ,&nbsp;Cetin Celik M.D.","doi":"10.1016/j.nut.2025.112873","DOIUrl":"10.1016/j.nut.2025.112873","url":null,"abstract":"<div><h3>Introduction</h3><div>We aimed to investigate the relationship between preoperative nutritional status with postoperative interleukin-10 (IL-10) and neopterin in gynecologic oncology cases.</div></div><div><h3>Materials and methods</h3><div>This prospective study included cases hospitalized in our clinic. Preoperative cases were divided into two groups as low and high risk according to Nutritional risk score (NSR-2002). Demographic and clinical characteristics and questionnaires including the NSR-2002 form were recorded. IL-10 and neopterin levels were analyzed 1 week postoperatively.</div></div><div><h3>Results</h3><div>Forty-five low-risk and 43 high-risk cases were evaluated. The mean ages of the cases were 56.7 ± 7.8 and 57.2 ± 14.3 years, respectively, and no significant difference was found between them (<em>P</em> = 0.854). There was a statistically significant difference between the two groups in terms of upper arm circumference (<em>P</em> = 0.043), triceps skinfold thickness (<em>P</em> = 0.010), shorter wound healing time (<em>P</em> = 0.009), neopterin (<em>P</em> = 0.037), IL-10 (<em>P</em> = 0.043), preoperative ferritin (<em>P</em> = 0.001), hemoglobulin (<em>P</em> = 0.026), albumin (<em>P</em> = 0.047), postoperative ferritin (<em>P</em> = 0.015), hemoglobulin (<em>P</em> = 0.044), and albumin (<em>P</em> = 0.042) levels in favor of the low-risk group. Among the significant factors, only wound healing time had positive correlation (<em>P</em> = 0.006, r = +0.290).</div></div><div><h3>Conclusions</h3><div>Nutritional status is closely related to case recovery in the postoperative period. Postoperative changes to high interleukin-10 and neopterin levels in cases with low nutritional index show the importance of nutrition in the postoperative period.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"139 ","pages":"Article 112873"},"PeriodicalIF":3.2,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144549410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exercise-induced weight loss modulates brain iron and Omega-3 fatty acid metabolism in middle-aged obese rats","authors":"Wen-Ling Lin Ph.D. ,&nbsp;Chun-Chao Chang Ph.D. ,&nbsp;Seu-Hwa Chen Ph.D. ,&nbsp;Amelia Faradina Ph.D. ,&nbsp;Wan-Chun Chiu Ph.D. ,&nbsp;Shih-Yi Huang Ph.D. ,&nbsp;Te-Hsuan Tung Ph.D. ,&nbsp;Sung-Hui Tseng Ph.D. ,&nbsp;Anatoly V. Skalny Ph.D. ,&nbsp;Alexey A. Tinkov Ph.D. ,&nbsp;Michael Aschner Ph.D. ,&nbsp;Jung-Su Chang Ph.D.","doi":"10.1016/j.nut.2025.112872","DOIUrl":"10.1016/j.nut.2025.112872","url":null,"abstract":"<div><h3>Objectives</h3><div>Midlife is a critical period for the onset of obesity and cognitive decline, which are often linked to disorders of iron and omega-3 long-chain polyunsaturated fatty acids (LCPUFAs). The aim was to investigate the effects of treadmill exercise on brain iron and LCPUFA metabolism.</div></div><div><h3>Methods</h3><div>Middle-aged male rats were fed either a control diet or a 50% high-fat diet (HFD), with or without iron enrichment (2 g ferric iron/kg diet), for 8 weeks to induce dysmetabolic iron overload syndrome (DIOS). This was followed by 4 weeks of a hypocaloric diet and treadmill aerobic exercise (3 kcal/g of diet, 9.4% fat, 37 mg iron/kg of diet), and 1 week of behavioral testing. Hippocampal LCPUFA profiles were measured using ultra-performance liquid chromatography-mass spectrometry (UPLC-MS).</div></div><div><h3>Results</h3><div>Consumption of an HFD significantly reduced hippocampal omega-3 LCPUFAs, with a further reduction in the DIOS group following the exercise intervention (<em>p</em> for trend &lt; 0.001). A Western blot analysis showed that exercise/hypocaloric diet-mediated weight loss restored brain iron and LCPUFA metabolism by enhancing proteins involved in iron efflux (ferroportin), LCPUFA biogenesis (desaturases and elongase), phospholipid remodeling (acyl-CoA synthase long-chain family member and lysophosphatidyl choline acyltransferase), and neurotrophins (brain-derived neuro trophic factor), while reducing β-amyloid (all <em>p</em> &lt; 0.05). The intervention restored cognitive function, although this effect was more pronounced in middle-aged obese rats without DIOS.</div></div><div><h3>Conclusions</h3><div>These findings suggest that while exercise-induced weight loss supports brain health, additional strategies may be needed to address iron-related challenges in DIOS for optimal cognitive outcomes.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"139 ","pages":"Article 112872"},"PeriodicalIF":3.2,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144549417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute effects of cocoa flavanols on cognitive control and response inhibition","authors":"Ahmet Altinok,&nbsp;Monica Moruzzi,&nbsp;Elkan G. Akyürek","doi":"10.1016/j.nut.2025.112860","DOIUrl":"10.1016/j.nut.2025.112860","url":null,"abstract":"<div><div>In this pre-registered study, we investigated the effects of acute cocoa flavanol (CF) consumption on cognitive control and response inhibition processes, at two different dosage levels. This crossover study was randomized, placebo-controlled, gender-balanced, and double-blind, and included 36 healthy adult participants. Participants consumed three different drinks across separate sessions: a placebo drink containing alkalized cocoa powder, a low-dose drink with 415 mg CF, and a medium-dose drink with 623 mg CF, both derived from flavanol-rich cocoa powder. Following each treatment, participants completed the Flanker, Simon, and Go/No-go tasks in a counterbalanced order. We analyzed accuracy and response times for congruent and incongruent trials in the Simon and Flanker tasks, and commission errors, omission errors, and response times in the Go/No-go task. The acute effects of CF on cognitive control and response inhibition were examined using (Generalized) Linear Mixed Model analysis, which included random intercepts, fixed effects, and random slopes. Results revealed that neither dose of CF acutely improved accuracy, interference scores, errors, or response times in these three tasks. Furthermore, neither participant gender nor BMI predicted performance in cognitive control or response inhibition beyond the effects of the treatment conditions. Taken together, these findings suggest that acute cocoa flavanol consumption has no significant effect on cognitive control or response inhibition in healthy young adults.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"139 ","pages":"Article 112860"},"PeriodicalIF":3.2,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144534713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges in implementing a multidisciplinary integrative oncology intervention for young women with localized breast cancer","authors":"Fernanda Sarahí Fajardo-Espinoza ,&nbsp;Daniela Martínez-Palacios ,&nbsp;Yanira E. Rodríguez-Fonseca ,&nbsp;Dana Aline Pérez-Camargo ,&nbsp;Carmen L. Gálvez-Hernández ,&nbsp;Tavata Bejarano-Colina ,&nbsp;Juan A. Torres-Domínguez ,&nbsp;Ana Laura Rodríguez-Velázquez ,&nbsp;Verónica Cedillo-Compeán ,&nbsp;Rosa L. López-Bejarano ,&nbsp;Virginia Isabel Enríquez-Cárcamo ,&nbsp;Lourdes Lopez-Castro ,&nbsp;Raquel María Menéndez-Aponte y Guzmán ,&nbsp;Alicia González-Pérez ,&nbsp;Aline Barranco-Cortés ,&nbsp;Aimée C. Madariaga-Cobos ,&nbsp;Lina M. Blandón-Hernández ,&nbsp;Sara Aileen Cabrera-Nieto ,&nbsp;Lucero I. Labra-Alvarado ,&nbsp;Alejandro Mohar ,&nbsp;Marlid Cruz-Ramos","doi":"10.1016/j.nut.2025.112859","DOIUrl":"10.1016/j.nut.2025.112859","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Objectives&lt;/h3&gt;&lt;div&gt;This study examines the challenges and facilitators in implementing a lifestyle and integrative oncology intervention, which aims to provide education and personalized support related to oncology care, nutrition, rehabilitation, mindfulness, and psychological guidance. Breast cancer (BC) treatment is associated with disabilities among young women with BC, who experience side effects and psychosocial distress that impact their quality of life, physical functioning, and psychological well-being. There is an urgent need to implement multidisciplinary integrative oncology interventions to promote healthy lifestyles and improve the quality of life for women who are about to receive active treatment for BC. Integrative oncology is emerging as a discipline that combines complementary techniques with standard oncology, addressing the individual in all dimensions and encouraging a healthier lifestyle. However, it is essential to conduct studies on implementing and adopting new strategies, such as integrative oncology, in referral centers to evaluate opportunities for effective implementation.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;A qualitative analysis was conducted to identify the challenges and facilitators perceived by patients and providers in implementing a hybrid (on-site and online) integrative oncology multidisciplinary intervention. Women aged 18 to 39 with a recent BC stage I-III diagnosis and providers participated in structured interviews based on the Consolidated Framework for Implementation Research (CFIR) and Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) tools. The data from this framework analysis provided insights for developing an effective intervention and helped identify potential barriers and facilitators.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Patients and providers reported that implementing the intervention was challenging, primarily due to time constraints, follow-up requirements, and the need to sustain patient motivation. The hybrid modality enhances motivation and adherence while addressing limitations such as the distance necessary to attend in-person sessions. However, some patients encountered difficulties related to technology and scheduling virtual sessions. Despite these challenges, the intervention proved feasible in assisting patients in maintaining a healthy lifestyle since their diagnosis and throughout their active BC oncology treatment.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusions&lt;/h3&gt;&lt;div&gt;Integrative oncology interventions emerge as a strategy to maintain a healthy lifestyle, positively impacting quality of life during BC active treatment, and have gained widespread acceptance globally. However, their routine use and inclusion in BC standard treatment at oncology centers remain limited. This study underscores the importance of providing comprehensive care to YWBC from the outset of their treatment. Overcoming barriers such as patient ideologies, healthcare personnel, geograph","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"139 ","pages":"Article 112859"},"PeriodicalIF":3.2,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144572113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insufficient diet management and monitoring of patients during phase 2 and 3 pharmaceutical clinical trials: A narrative review with a systematic approach","authors":"Nicole Y. McWhorter MS RD ,&nbsp;Tracy B. Lowe PhD ,&nbsp;Sara M. Sarasua PhD ,&nbsp;Christopher L. Farrell PhD ,&nbsp;Melanie B. Gillingham PhD","doi":"10.1016/j.nut.2025.112861","DOIUrl":"10.1016/j.nut.2025.112861","url":null,"abstract":"<div><div>Clinical trials play a vital role in developing new medications for nutrition-related diseases, such as phenylketonuria (PKU), obesity, and diabetes. Dietary management is often a critical component of these trials, as consistency in diet can significantly influence outcomes and the evaluation of drug efficacy. While the Federal Drug Administration (FDA) provides guidance on managing and monitoring diets in clinical trials, the extent to which these practices are implemented remains unclear. This review examines diet management practices in phase 2 and 3 clinical trials for weight loss, type 2 diabetes, and PKU. A systematic review methodology was employed, with PubMed and Cochrane searches identifying 14 articles for weight loss and diabetes trials and 5 articles for PKU trials that met inclusion criteria. Key practices include the use of inclusion/exclusion criteria, study endpoints incorporating multiple biomarkers, and the implementation of specific dietary protocols. Weight loss and PKU trials were more likely to employ detailed dietary guidelines than diabetes trials. However, all the reviewed studies lacked critical elements outlined in published nutrition research guidelines. This review underscores the variability and deficiencies in diet management practices in clinical trials for nutrition-related disorders. These gaps highlight the need for more standardized and transparent approaches to dietary monitoring and reporting in order to improve the reliability and reproducibility of trial outcomes.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"139 ","pages":"Article 112861"},"PeriodicalIF":3.2,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144534714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}