Nutrition最新文献

{"title":"Assessing nutritional and hydration status in patients with a diabetic foot ulcer: Agreement between hand-to-hand and hand-to-foot bioimpedance methods","authors":"Kristof Van Dessel M.Sc. ,&nbsp;Patrick Lauwers M.D., Ph.D. ,&nbsp;An Verrijken Ph.D. ,&nbsp;Christophe De Block M.D., Ph.D. ,&nbsp;Eveline Dirinck M.D., Ph.D.","doi":"10.1016/j.nut.2026.113136","DOIUrl":"10.1016/j.nut.2026.113136","url":null,"abstract":"<div><h3>Objectives</h3><div>Malnutrition is prevalent among people with a diabetic foot ulcer (DFU) and is associated with impaired wound healing and increased amputation risk. Assessing fat-free mass (FFM) is crucial for diagnosing malnutrition. However, hand-to-foot (HF) bioelectrical impedance analysis (BIA) measurements are often not feasible due to amputations or ulcerated feet. This study evaluates the agreement between hand-to-hand (HH) and HF BIA measurements in assessing body composition, hydration, and nutritional status in patients with DFU.</div></div><div><h3>Methods</h3><div>In this cross-sectional study, 164 patients with DFU underwent HF and HH BIA measurements to assess body composition. Malnutrition was diagnosed using the GLIM criteria. Agreement between methods was analyzed using one-sample t-tests, Bland–Altman plots, intra-class correlation, and Cohen’s d. Over- or underestimation was defined as deviation &gt;10% from HF values.</div></div><div><h3>Results</h3><div>Statistically significant but small differences were observed between HF and HH measurements for resistance (<em>P</em> &lt; 0.001), reactance (<em>P</em> = 0.036), and phase angle (<em>P</em> &lt; 0.001). Strong agreement was found for body composition and hydration metrics. Malnutrition was diagnosed in 32.3% of patients, with HH showing 88.7% accuracy in identifying malnourished individuals, similar to HF (89%).</div></div><div><h3>Conclusions</h3><div>HH BIA is a reliable alternative for assessing body composition and nutritional status in patients with DFUs. Although statistically significant differences were found in resistance, reactance, and phase angle, the derived body composition and hydration indices showed strong consistency between methods (ICC &gt; 0.75). The small systematic biases observed were clinically negligible, supporting the use of HH BIA when HF measurements are unfeasible.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"146 ","pages":"Article 113136"},"PeriodicalIF":3.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147290136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of alternate-day fasting combined with and without voluntary running exercise on body composition and energy metabolism in young adult, normal-weight mice","authors":"Ryona Suzuki M.Sc. ,&nbsp;Kazuhiko Higashida Ph.D. ,&nbsp;Sho Hatayama Ph.D. ,&nbsp;Tsutomu Fukuwatari Ph.D. ,&nbsp;Naoya Nakai Ph.D.","doi":"10.1016/j.nut.2026.113116","DOIUrl":"10.1016/j.nut.2026.113116","url":null,"abstract":"<div><h3>Objectives</h3><div>The effects of alternate-day fasting (ADF) on body composition and metabolic function in young, healthy and nonobese, individuals remain insufficiently understood. We investigated the effects of ADF with and without voluntary running exercise on body composition, energy metabolism, and biochemical parameters in mice.</div></div><div><h3>Methods</h3><div>Eight-week-old male mice were divided into ad libitum (AL) and ADF groups, which were further divided into sedentary (SED) and voluntary wheel running exercise (EX) sub-groups. An oral glucose tolerance test (OGTT) was conducted in week 6 of the experimental period. Mice were euthanized in week 7 of the experimental period, and blood and tissue samples were collected for biochemical analysis.</div></div><div><h3>Results</h3><div>The total food intake was significantly increased in the AL-EX group and decreased in the ADF-SED group. Voluntary running distance was reduced by ADF, particularly on feeding days. Skeletal muscle mass per body weight (BW) was reduced in ADF compared with AL. The epididymal fat weight per BW was reduced in EX and increased in ADF. OGTT results revealed that ADF and EX independently improved glucose tolerance, but their combination showed no additive effect. EX increased the synthesis of mitochondrial enzymes in skeletal muscle and hepatic triglyceride content, whereas ADF led to increased hepatic fatty acid synthase levels.</div></div><div><h3>Conclusions</h3><div>These findings suggest that ADF does not enhance exercise-induced improvements in body composition and may attenuate some beneficial effects of voluntary exercise in healthy young adult mice, potentially because of reduced physical activity associated with ADF.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"146 ","pages":"Article 113116"},"PeriodicalIF":3.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146213470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary advice alone or with oral nutritional supplements after hospital discharge in colorectal cancer surgery patients: Five year follow-up of a randomized controlled trial","authors":"Shanjun Tan ,&nbsp;Qiulei Xi ,&nbsp;Zhige Zhang ,&nbsp;Mingyue Yan,&nbsp;Qingyang Meng,&nbsp;Qiulin Zhuang ,&nbsp;Guohao Wu","doi":"10.1016/j.nut.2026.113113","DOIUrl":"10.1016/j.nut.2026.113113","url":null,"abstract":"<div><h3>Objectives</h3><div>The efficacy of dietary advice alone compared to dietary advice supplemented with oral nutritional supplements following hospital discharge in post-cancer surgery patients remains a contentious issue. This study was to assess whether combining dietary advice with oral nutritional supplements improves long-term overall survival and other outcomes, compared with dietary advice alone, in patients following discharge after colorectal cancer surgery.</div></div><div><h3>Methods</h3><div>We conducted a 5-year follow-up of a two-arm randomized controlled trial involving colorectal cancer surgery patients at nutritional risk. The control group was offered dietary advice alone, in contrast to the intervention group, which was provided with both oral nutritional supplements and dietary advice. Overall survival was the primary outcome, while secondary outcomes encompassed nonelective hospital readmissions, quality of life, and functional outcomes such as 6-minute walk distance and handgrip strength.</div></div><div><h3>Results</h3><div>This analysis included 193 patients who completed the 5-year follow-up (97 in the intervention group and 96 in the control group). The intervention group demonstrated a significantly higher overall survival rate compared to the control group for the primary outcome (<em>P</em> = 0.042). The nutritional intervention emerged as a favorable prognostic factor for overall survival, even after adjustment for confounding variables (hazard ratio 0.61, 95% confidence interval 0.38–0.98, <em>P</em> = 0.042). However, the secondary outcomes did not differ significantly between the 2 groups (all <em>P</em> &gt; 0.05).</div></div><div><h3>Conclusions</h3><div>Patients with nutritional risk after colorectal cancer surgery who received dietary advice combined with oral nutritional supplements posthospital discharge exhibited improved overall survival compared to those who received dietary advice alone. The results indicate that providing dietary advice combined with oral nutritional supplements may be beneficial for patients after hospital discharge following cancer surgery.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"146 ","pages":"Article 113113"},"PeriodicalIF":3.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146258856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimising SARC-F cut-off for sarcopenia screening: A comparative analysis with muscle strength and physical performance tests","authors":"Deniz Cengiz M.D. ,&nbsp;Arzu Okyar Baş M.D. ,&nbsp;Yelda Öztürk M.D. ,&nbsp;Ceyda Kayabaşı M.D. ,&nbsp;Murat Pehlivan M.D. ,&nbsp;Özge Özgün M.D. ,&nbsp;Okan Turhan M.D. ,&nbsp;İskender Arda Nacar M.D. ,&nbsp;Mert Eşme M.D. ,&nbsp;Cafer Balcı M.D. ,&nbsp;Burcu Balam Doğu M.D. ,&nbsp;Mustafa Cankurtaran M.D. ,&nbsp;Meltem Gülhan Halil M.D.","doi":"10.1016/j.nut.2026.113132","DOIUrl":"10.1016/j.nut.2026.113132","url":null,"abstract":"<div><h3>Objectives</h3><div>Sarcopenia, a prevalent geriatric syndrome with multifactorial origins, is strongly influenced by malnutrition alongside immobility and chronic illness and contributes substantially to falls, disability, and mortality. The (Strength, Assistance with walking, Rise from a chair, Climb stairs, and Falls (SARC-F) questionnaire is widely used to screen for probable sarcopenia; however, the conventional cut-off of ≥4 has yielded insufficient sensitivity across studies. The aim of the study was to evaluate how SARC-F scores correspond to muscle strength and physical performance tests endorsed by the EWGSOP2 algorithm and to determine the most suitable cut-off for screening probable sarcopenia in older adults.</div></div><div><h3>Methods</h3><div>This retrospective cross-sectional study included community-dwelling adults aged ≥65 years who attended a tertiary geriatric outpatient clinic (January 2022–May 2024). Patients with active malignancy, non-ambulatory status, or missing performance data were excluded. Diagnostic accuracy of SARC-F thresholds was assessed against handgrip strength (HGS), the sit-to-stand test (STST), 4-meter gait speed, and the Timed Up and Go (TUG) test using receiver operating characteristic analysis.</div></div><div><h3>Results</h3><div>A total of 1,355 participants (mean age 74.0 ± 6.0 years; 64.9% female) were analyzed. Prevalence of SARC-F ≥4 was 22.2%. For HGS and STST, a cut-off of ≥2 yielded the most favorable discrimination (AUC = 0.705 and 0.735, respectively). Gait speed showed the best accuracy at ≥3 (AUC = 0.788), while TUG demonstrated the highest performance at ≥4 (AUC = 0.881).</div></div><div><h3>Conclusions</h3><div>SARC-F performance varies across muscle strength and functional domains. A threshold of ≥2 may enhance early detection of sarcopenia in community-dwelling older adults, while higher cut-offs better reflect advanced functional impairment.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"146 ","pages":"Article 113132"},"PeriodicalIF":3.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147326853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frequency of fluid versus nutrition discussion on rounds in neonatal intensive care units: Is fluid intake a heuristic for nutrition intake?","authors":"Gustave H. Falciglia M.D., M.S.C.I., M.S.H.Q.S. ,&nbsp;Karna Murthy M.D., M.Sc. ,&nbsp;Daniel T. Robinson M.D., M.Sc.","doi":"10.1016/j.nut.2026.113107","DOIUrl":"10.1016/j.nut.2026.113107","url":null,"abstract":"<div><div>Clinicians in the neonatal intensive care unit discuss fluid more frequently than energy and macronutrient (protein, fat and carbohydrate) intake. These findings suggest clinicians use fluid intake as a heuristic for nutrition intake which may lead to nutritional deficits because nutrition concentration varies by source.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"146 ","pages":"Article 113107"},"PeriodicalIF":3.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146161846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serine modulates insulin resistance during short-term bed rest","authors":"Alja Ivetac ,&nbsp;Teresa Cannito ,&nbsp;Alessio Nunnari M.D.,&nbsp;Mariella Sturma ,&nbsp;Filippo Giorgio Di Girolamo Phar. Ph.D.,&nbsp;Gianni Biolo M.D., Ph.D.","doi":"10.1016/j.nut.2026.113121","DOIUrl":"10.1016/j.nut.2026.113121","url":null,"abstract":"<div><h3>Background</h3><div>Insulin resistance (IR) manifesting as a result of muscle unloading is often accompanied by an altered amino acid (AA) profile. The aim of this study was to assess the potential impact of AAs on IR during inactivity.</div></div><div><h3>Methods</h3><div>Plasmatic AA, glucose, and insulin were retrospectively analyzed from three different bed rest studies (BR1, BR2, BR3) involving 26 young healthy males. Since AAs were analyzed on different days, we imputed all missing values with multivariate imputation by chained equations, which allowed us to evaluate trends of plasmatic AAs in relation to IR (HOMA IR) during 9 d of inactivity. A generalized linear mixed model (GLMM) was fitted to examine the effect of selected plasmatic AAs (predictors) on HOMA IR (outcome). Results of GLMM were further validated with data from BR1 and BR2 (19 subjects), in which AAs were analyzed on days 1, 5, and 9.</div></div><div><h3>Results</h3><div>Serine exhibited a sig. negative fixed effect on HOMA IR [−0,015] (<em>P</em> = 0.006), while HOMA-IR had no sig. effect on serine (<em>P</em> = 0.507), suggesting a unidirectional relationship. Furthermore, data from BR1 and BR2 confirmed the inverse effect: serine levels sig. increased during the initial days (+13%), followed by a sig. drop from fifth to the ninth d (−6.5%). When serine was available, HOMA IR was not sig. affected. When serine availability dropped, HOMA IR continued to rise, reaching a sig. difference from baseline values to ninth d of BR (+27%).</div></div><div><h3>Conclusion</h3><div>Our findings indicate that serine can have an inverse impact on IR and not vice versa. Upholding serine levels during short-term BR could have a protective role against IR.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"146 ","pages":"Article 113121"},"PeriodicalIF":3.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147284623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of the ketogenic-caloric restricted diet on metabolic endotoxemia and metabolic health in adults with prediabetes: A randomized controlled trial","authors":"Aseel Jawamis MSc,&nbsp;Hayder AL-Domi PhD,&nbsp;Najd Al Sarayreh MSc","doi":"10.1016/j.nut.2026.113119","DOIUrl":"10.1016/j.nut.2026.113119","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the effects of a ketogenic-caloric-restricted (KD+CR) diet on metabolic endotoxemia and related metabolic markers in adults with obesity and prediabetes.</div></div><div><h3>Methods</h3><div>A randomized controlled trial was conducted among 90 adults with obesity and prediabetes. Participants were randomized to three groups: 1) KD+CR, 2) normal diet with caloric restriction (ND+CR), or 3) normal diet without caloric restriction (ND). Lipopolysaccharides (LPS), inflammatory biomarkers, fasting glucose, insulin, HOMA-IR, and anthropometric measures were assessed at baseline and week 12.</div></div><div><h3>Results</h3><div>After 12 wk, serum LPS levels were significantly higher in KD+CR group compared with ND+CR and ND (158.6 ± 6.9 versus 129.6 ± 6.6, 126.7 ± 7.0; <em>P</em> = 0.004). Interleukin-6 (IL-6) significantly decreased in KD+CR versus ND (2.4 ± 0.2, 3.9 ± 0.2; <em>P</em> = 0.004). Insulin and HOMA-IR were significantly lower in KD+CR and ND+CR than in ND (insulin: 12.0 ± 1.1, 13.9 ± 1.0, 19.3 ± 1.1; <em>P</em> &lt; 0.001) (HOMA-IR: 2.9 ± 0.28, 3.2 ± 0.27, and 4.7 ± 0.29; <em>P</em> &lt; 0.001). Body weight and fat mass reductions were greater in the KD+CR group than in the ND+CR and ND groups (body weight: –10.5%, –3.9%, –4.5%; <em>P</em> &lt; 0.001), (body-fat mass: –21.7%, –7.7%, –9.8%; <em>P</em> &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>A 12-wk KD+CR diet in adults with obesity and prediabetes improved inflammatory markers, insulin sensitivity, and body composition, alongside a significant increase in serum LPS levels and altered LPS–cytokine dynamics. The long-term metabolic consequences of LPS changes during prolonged ketogenic exposure warrant investigation in future studies.</div></div><div><h3>Trial registration</h3><div>This trial was registered with ClinicalTrials.gov (NCT06911879).</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"146 ","pages":"Article 113119"},"PeriodicalIF":3.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147308518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reassessing the nutrition policy landscape: Mapping nutrition policies and analysing malnutrition burdens in selected South Asian countries","authors":"Sourav Bhattacharjee M.A. ,&nbsp;Taasha Mishra B.A. ,&nbsp;Binayak Kandapan Ph.D. ,&nbsp;Tamal Reja M.Phil. ,&nbsp;Jalandhar Pradhan Ph.D.","doi":"10.1016/j.nut.2026.113115","DOIUrl":"10.1016/j.nut.2026.113115","url":null,"abstract":"<div><div>Malnutrition is an extensive and complicated public health issue experienced by countries across South Asia that affects millions of lives and impedes the socioeconomic progress of nations. Despite decades of policies, programs, and interventions the region continues to suffer from high rates of undernutrition, overweight, obesity, and micronutrient deficiencies, as well as maternal and child malnutrition. In this article we examine the impact of malnutrition in South Asia through the public policy lens, with an emphasis on policy formulation and the evaluation of implementation constraints. By drawing on national policy mappings and empirical analyses, we highlight policy architectures across the region. This public policy cycle framework and Kingdon’s Multiple Streams Framework have been applied to analyze how certain issues impact policy agendas, how decisions are made, and how implementation is carried out. Results suggest that while early childhood and pregnancy receive significant policy attention, adolescence and the preconception period are frequently ignored, limiting the effectiveness of maternal and child health interventions. The implications of this conceptual gap are severe, as a large proportion of individuals in the reproductive-age group of most South Asian nations are adolescents of “marriageable age” per their respective cultures, who are often married and become parents of children before they enter adulthood. This is a sensitive situation in the South Asian health scenario that needs to be addressed immediately. We argue for an urgent pivot toward preconception-centered, equity-driven interventions that align national commitments with global nutrition targets such as the Sustainable Development Goals and the World Health Organization’s Global Nutrition Targets 2025.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"146 ","pages":"Article 113115"},"PeriodicalIF":3.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147321850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of diet and physical activity in managing anxiety and depression: A scoping review","authors":"Tatiana Palotta Minari Ph.D.,&nbsp;Mateus do Carmo Bardella M.Sc.,&nbsp;Gustavo Padovani do Carmo M.Sc.,&nbsp;Arthur Polveiro da Silva Ph.D.,&nbsp;Simone Aparecida Berrido dos Reis,&nbsp;Simone Aparecida Hoffmann,&nbsp;Vanessa Alves Lobato,&nbsp;Luciana Pellegrini Pisani Ph.D.","doi":"10.1016/j.nut.2026.113117","DOIUrl":"10.1016/j.nut.2026.113117","url":null,"abstract":"<div><h3>Background</h3><div>Lifestyle interventions involving diet, nutritional supplementation, and physical activity have gained attention as strategies for improving mental health. However, evidence linking these approaches to anxiety and depression remains dispersed across heterogeneous study designs and outcomes. This scoping review aimed to map the existing literature on dietary, supplementation, and physical activity interventions related to anxiety and depression, describing intervention characteristics, studied populations, assessed outcomes, and key evidence gaps.</div></div><div><h3>Methods</h3><div>A scoping review was conducted in accordance with PRISMA-ScR guidelines. Searches were performed in PubMed, Web of Science, CrossRef, and Google Scholar. Eligible studies examined dietary patterns, nutritional supplements, physical activity, or combined lifestyle interventions and reported outcomes related to anxiety, depression, or associated psychological domains. Studies were charted and categorized by intervention type and outcome focus.</div></div><div><h3>Results</h3><div>Forty-five studies met the inclusion criteria. Most primarily assessed depressive symptoms, whereas anxiety was less frequently examined and rarely defined as a primary outcome. Dietary interventions predominantly focused on depression-related outcomes, while physical activity and supplementation studies more often included anxiety, stress, and broader psychological measures. Substantial heterogeneity was observed across intervention formats, populations, follow-up durations, and outcome measures. Some studies also reported secondary outcomes, including sleep, cognitive performance, biological markers, or neuroimaging findings.</div></div><div><h3>Conclusions</h3><div>Evidence remains unevenly distributed across lifestyle interventions and mental health outcomes, with a predominant focus on depression. Key gaps include anxiety-specific interventions, standardized outcomes, long-term follow-up, and integrated multimodal approaches. These findings help inform future primary research and the development of targeted systematic reviews.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"146 ","pages":"Article 113117"},"PeriodicalIF":3.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146213571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting 10-year survival in early and locally advanced breast cancer: prognostic value of nutritional status and body composition","authors":"Derya Hopanci Bicakli Ph.D., R.D. ,&nbsp;Asli Gecgel M.D. ,&nbsp;Oguzcan Ozkan M.D. ,&nbsp;Atalay Aktuna M.D. ,&nbsp;Mert İsci M.D. ,&nbsp;Pinar Gursoy M.D.","doi":"10.1016/j.nut.2026.113133","DOIUrl":"10.1016/j.nut.2026.113133","url":null,"abstract":"<div><h3>Aim</h3><div>This study aimed to evaluate the prognostic impact of nutritional status assessed by the Patient-Generated Subjective Global Assessment (PG-SGA) and body composition parameters on 10-year overall survival (OS) in patients with early and locally advanced breast cancer.</div></div><div><h3>Methods</h3><div>This retrospective longitudinal study included 437 women aged over 18 years diagnosed with stage I–III breast cancer between 2015-2017. Patients with metastatic disease at diagnosis or incomplete data were excluded. Nutritional status was assessed using PG-SGA. Body composition was measured via bioelectrical impedance analysis. Clinical data and antropometric measuremets were collected from electronic medical records. ROC analysis identified cut-off values, and Kaplan-Meier and Cox regression analyses evaluated the impact of nutrition and body composition on OS.</div></div><div><h3>Results</h3><div>The median follow-up was 117.7 months (mean 121.2 ± 51.1 months). PG-SGA cut-off value of 5.5 effectively stratified patients into low- and high-risk nutritional groups. Higher PG-SGA scores were significantly associated with poorer OS (HR = 1.057; 95% CI: 1.021–1.094; <em>p</em> = .002). Anthropometric measurements including calf circumference, mid-arm circumference, skinfold thickness, body mass index (BMI), fat-free mass, and muscle mass predicted survival outcomes (all <em>p</em> &lt; .05). Patients with PG-SGA ≥5.5 had a median survival of 145.8 months (95% CI: 130.3–161.4), compared to 285.7 months (95% CI: 267.9–303.5) in those with lower scores (<em>p</em> &lt; .001). Similarly, higher body composition metrics correlated with significantly longer survival. Multivariate analysis confirmed PG-SGA and body composition parameters as independent prognostic factors, adjusting for age, stage, disease progression (defined as the development of distant metastases during follow-up), and receipt of systemic treatment during follow-up.</div></div><div><h3>Conclusion</h3><div>Nutritional status and body composition are valuable predictors of long-term survival in early and locally advanced breast cancer. Defining a PG-SGA threshold in this setting, our study highlights the importance of integrating nutritional assessment into routine care, even beyond advanced disease.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"146 ","pages":"Article 113133"},"PeriodicalIF":3.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147348663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}