Nutrition最新文献

{"title":"Impact of a multicomponent food-as-medicine intervention on behavioral and mental health outcomes for patients with and without food insecurity","authors":"Marcela D. Radtke Ph.D. ,&nbsp;June M. Tester M.D. ,&nbsp;Lan Xiao Ph.D. ,&nbsp;Wei-ting Chen Ph.D. ,&nbsp;Benjamin O. Emmert-Aronson Ph.D. ,&nbsp;Elizabeth A. Markle Ph.D. ,&nbsp;Steven Chen M.D. ,&nbsp;Lisa G. Rosas Ph.D., M.P.H.","doi":"10.1016/j.nut.2025.112734","DOIUrl":"10.1016/j.nut.2025.112734","url":null,"abstract":"<div><h3>Background</h3><div>Increasingly, food-as-medicine (FAM) programs are being implemented as a strategy for improving the health of patients. However, current policies limit nutrition resources to patients with specific chronic condition diagnoses and do not include food insecurity as a qualifying condition.</div></div><div><h3>Objective</h3><div>Explore the impact of Recipe4Health (R4H), a multicomponent FAM intervention, on behavioral and mental health outcomes in patients with and without food insecurity.</div></div><div><h3>Methods</h3><div>Patients (n = 336) with diet-related chronic conditions and/or food insecurity were referred to R4H, which included 16-weekly produce deliveries and behavioral intervention sessions. Food security status was assessed using the U.S. Department of Agriculture 6-item survey. Outcomes included vegetable/fruit intake, physical activity (PA) and mental health. Within- and between-group pre-post changes were assessed using repeated-measures linear mixed-effects models, adjusting for baseline.</div></div><div><h3>Results</h3><div>The majority of patients had one or more chronic conditions (96%) and identified as food insecure (62%). Patients with food insecurity experienced significant increases in daily servings of vegetables/fruit (+0.38 ± 0.15; <em>P</em> = 0.01) and minutes of moderate-to-vigorous PA per week (+28.94 ± 9.84; <em>P</em> &lt; 0.01). Patients with food security did not experience significant increases in vegetables/fruit (<em>P</em> = 0.09) or PA (<em>P</em> = 0.06). Food-insecure and food-secure patients both experienced significant improvements in loneliness, anxiety, and depressive symptoms from baseline (<em>P</em> &lt; 0.01 for all). Between-group differences were observed only for anxiety, where patients with food security experienced significant improvements in anxious symptoms compared to food-insecure patients (–1.24 [–2.33, –0.14]; <em>P</em> = 0.03).</div></div><div><h3>Conclusion</h3><div>Policymakers may consider expanding eligibility criteria to include food insecurity as an independent qualifying condition for FAM.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"134 ","pages":"Article 112734"},"PeriodicalIF":3.2,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143679271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of node assortativity and internalizing symptoms with ketogenic diet effectiveness in pediatric patients with drug-resistant epilepsy","authors":"Yi-Fen Chen MD ,&nbsp;Wei-Che Lin MD, PhD ,&nbsp;Ting- Yu Su MD ,&nbsp;Tzu-Yun Hsieh MD ,&nbsp;Kai-Yin Hung MSc ,&nbsp;Mei-Hsin Hsu MD ,&nbsp;Ying-Jui Lin MD ,&nbsp;Hsuan-Chang Kuo MD ,&nbsp;Pi-Lien Hung MD, PhD","doi":"10.1016/j.nut.2025.112730","DOIUrl":"10.1016/j.nut.2025.112730","url":null,"abstract":"<div><h3>Background</h3><div>The ketogenic diet (KD) is an effective alternative therapy for drug-resistant epilepsy (DRE). However, there are no established predictors for KD effectiveness. We aimed to investigate the impact of 12 months of KD therapy (KDT) on brain connectivity, as measured by functional magnetic resonance imaging (fMRI), and its correlation with seizure control, behavioral/mood alterations, and parental stress.</div></div><div><h3>Methods</h3><div>Children with DRE were enrolled in this single-center, prospective cohort study from February 2020 to October 2021. They were divided into a control group and a KDT group. The Child Behavior Checklist (CBCL) and Parental Stress Index (PSI) were administered to parents at the initiation of KDT (T0) and at 12 months (T1). Resting-state fMRI was performed at T0 and at 6 months of KDT. The primary outcome was the between-group difference in the change of CBCL/PSI scores, and brain connectivity metrics after KDT, and the secondary outcome involved measuring their correlation with seizure reduction rates.</div></div><div><h3>Results</h3><div>Twenty-two patients with DRE were enrolled. We had 13 patients in the control group and 9 in the KDT group. Our data revealed that 12 months of KDT can reduce monthly seizure frequency. Several subscales of CBCL T-scores were higher at T0 compared with the control group, then becoming comparable at T1. The PSI scores from ’mothers’ reports reduced after receiving KDT. The changes in node assortativity (ΔAssortativity) were positively correlated with behavioral problems and negatively with seizure reduction rates in the KD group.</div></div><div><h3>Conclusions</h3><div>Twelve months of KDT can reduce monthly seizure frequency and improve mood/behavioral disturbances in patients with DRE. Furthermore, KDT could relieve primary caregivers’ stress. A lower ΔAssortativity value was associated with better behavioral outcomes and greater seizure reduction. The ΔAssortativity value in fMRI may be a crucial predictor for the effectiveness of KDT.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"134 ","pages":"Article 112730"},"PeriodicalIF":3.2,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143679272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of a predictive equation for resting energy expenditure in Japanese patients with interstitial lung disease","authors":"Keisuke Morikawa M.Sc. ,&nbsp;Hiroyuki Takemura ,&nbsp;Kana Kitayama ,&nbsp;Shogo Inaba ,&nbsp;Haruka Imaoka ,&nbsp;Yu Hashitsume ,&nbsp;Yuta Suzuki ,&nbsp;Osamu Hataji M.D. ,&nbsp;Kazuyuki Tabira Ph.D.","doi":"10.1016/j.nut.2025.112729","DOIUrl":"10.1016/j.nut.2025.112729","url":null,"abstract":"<div><h3>Background and Aims</h3><div>This study developed a prediction equation for resting energy expenditure (REE) in patients with interstitial lung disease (ILD) using indirect calorimetry and examined the errors in the prediction equation.</div></div><div><h3>Methods</h3><div>This study consisted of two key phases: Study 1 focused on developing the prediction equation for REE, whereas Study 2 evaluated the accuracy of this equation through validation and error analysis. In Study 1, REE was measured, and a regression model equation was created to predict REE using multiple regression analysis, with measured REE (mREE) as the dependent variable. In Study 2, a Bland-Altman analysis was conducted to examine the phylogenetic error and agreement between predicted REE (pREE) calculated from the prediction equations developed in Study 1 and mREE.</div></div><div><h3>Results</h3><div>In Study 1, mREE was significantly associated with fat-free mass (FFM), and the prediction equation for REE was 456.988 + 22.539 × FFM. The addition error (0.4 ± 166.1, 95% confidence interval (CI): −55.8 to 56.6, <em>P</em> = 0.988) and proportional error (<em>r</em> = 0.223, <em>P</em> = 0.191) between mREE and pREE were not significantly different, with an agreement of 69.4%.</div></div><div><h3>Conclusions</h3><div>The mREE prediction equation developed in this study showed no systematic errors and exhibited higher agreement compared with existing prediction equations. The prediction equation for REE specific to patients with ILD obtained in this study has the potential for clinical application.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"135 ","pages":"Article 112729"},"PeriodicalIF":3.2,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143783197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating plate waste in Lebanese hospitals: Implications for nutrition and resource management","authors":"Maha Hoteit Ph.D. ,&nbsp;Maroun Khattar M.Sc. ,&nbsp;Jana El Cheikh Mohamad M.Sc. ,&nbsp;Esraa Antar M.Sc. ,&nbsp;Dana Malli M.Sc. ,&nbsp;Nour Badereddine M.Sc. ,&nbsp;Ferial Fattouh M.Sc. ,&nbsp;Sami El Khatib Ph.D. ,&nbsp;Mohamad G. Abiad Ph.D. ,&nbsp;Hussein F. Hassan Ph.D.","doi":"10.1016/j.nut.2025.112715","DOIUrl":"10.1016/j.nut.2025.112715","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to quantify plate waste in Lebanese hospitals and evaluate the nutritional value.</div></div><div><h3>Methods</h3><div>A descriptive cross-sectional study was conducted between April 2023 and September 2023. It involved 155 inpatients from cardiovascular, gastrointestinal, obstetrics-gynecology and surgical wards across 16 hospitals throughout the Lebanese governorates. Plate waste was measured using a calibrated scale by measuring the food sent to the patient (before consumption) and the food left on the plate (after consumption) and computing the percentage of waste by dividing the grams discarded over the grams served, or through visual estimation. Nutritional analysis was performed to assess the magnitude of waste and its nutritional value.</div></div><div><h3>Results</h3><div>The plate waste represented 31.4% of the total amount of food served, equivalent to 366 tons annually in the participating hospitals. The discarded food accounted for 21.4% of the daily estimated energy requirement for patients. Waste was higher in hospitals located in rural areas (<em>P</em>-value = 0.771). The highest waste levels occurred in the obstetrics-gynecology ward and during lunchtime. On average, each patient wasted 404.7 kcal and 21.16 g protein per day. Vegetables were the most wasted food group. The highest mean daily plate waste was for lunch, representing 37.4% of the wasted weight, followed by dinner (35.6%), then breakfast (12.8%).</div></div><div><h3>Conclusion</h3><div>Lebanese hospitals should take pivotal steps to reduce plate waste, lessen its impacts and eventually increase patients’ satisfaction, as well as adopt relevant and efficient strategies to manage the waste generated, as this waste negatively impacts the environment, and puts patients at risk for malnutrition, hidden hunger, and even death.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"134 ","pages":"Article 112715"},"PeriodicalIF":3.2,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143611210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of age and educational qualifications on food label awareness: A study of edible oils and fats in India","authors":"Birendra Kumar Paliwal ,&nbsp;Peeyush Phogat ,&nbsp;Mohd Mudassir ,&nbsp;Jitendra Kumar ,&nbsp;Meher Wan","doi":"10.1016/j.nut.2025.112727","DOIUrl":"10.1016/j.nut.2025.112727","url":null,"abstract":"<div><h3>Background</h3><div>Consumer awareness of food labels plays a crucial role in promoting informed purchasing decisions and healthier dietary habits. However, the extent to which demographic factors such as age and education influence this awareness remains underexplored in the Indian context.</div></div><div><h3>Objective</h3><div>This study investigates the influence of age and education on consumer awareness of food labels of the edible oils and fats in India.</div></div><div><h3>Methods</h3><div>A cross-sectional survey was conducted with 2127 respondents using the questionnaire to ensure diverse demographic representation. Statistical analyses, including the chi-square test and Cramér's V, were applied to assess the relationships between educational qualifications, age, and food label awareness.</div></div><div><h3>Results</h3><div>The findings indicate a statistically significant association between educational qualifications and the practice of reading food labels. Higher educational attainment was correlated with greater food label awareness, though the strength of this association was weak. Age also influenced consumer behavior, with younger respondents demonstrating higher awareness levels compared to older age groups, although this relationship was less pronounced.</div></div><div><h3>Conclusion</h3><div>The study highlights the necessity of targeted educational interventions to improve food label literacy, thereby fostering healthier consumer choices and contributing to better public health outcomes.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"134 ","pages":"Article 112727"},"PeriodicalIF":3.2,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ellagic acid ameliorates atherosclerosis by inhibiting PCSK9 through the modulation of FoxO3 and HNF1α","authors":"Li-Tian Wang Ph.D. ,&nbsp;Huai-Liu Yin M.D. ,&nbsp;Ya-Min Jin M.D. ,&nbsp;Dan-Dan Hu Ph.D. ,&nbsp;Xiang-Xuan Yang M.D. ,&nbsp;Jun Sheng Ph.D. ,&nbsp;Ye-Wei Huang Ph.D. ,&nbsp;Xuan-Jun Wang Ph.D.","doi":"10.1016/j.nut.2025.112717","DOIUrl":"10.1016/j.nut.2025.112717","url":null,"abstract":"<div><h3>Introduction</h3><div>Proprotein convertase subtilisin/kexin type 9 (PCSK9) hinders the clearance of low-density lipoprotein cholesterol (LDL-C) by promoting the degradation of the low-density lipoprotein receptor (LDLR), leading to the accumulation of LDL-C and thus becoming an important cause of atherosclerosis. Ellagic acid, a naturally occurring polyphenol widely present in fruits, vegetables, and nuts, has attracted significant attention due to its potential role in the prevention and treatment of cardiovascular diseases. However, the molecular mechanisms by which ellagic acid alleviates atherosclerosis by inhibiting PCSK9 are not fully understood.</div></div><div><h3>Materials and Methods</h3><div>This study further validated the mechanism of action of ellagic acid through in vitro HepG2 cell experiments and a high-fat diet-induced ApoE^−/− mouse model.</div></div><div><h3>Results</h3><div>The results showed that ellagic acid significantly reduced the expression and secretion of PCSK9 while upregulating LDLR protein levels; its mechanism is related to the inhibition of hepatocyte nuclear factor 1α (HNF1α) expression and the promotion of forkhead box O3 (FoxO3) expression increase. Additionally, ellagic acid reduced aortic plaque deposition in mice induced by a high-fat diet; consistent with the in vitro experimental results, ellagic acid lowered the expression and secretion of PCSK9 and elevated LDLR protein levels by inhibiting HNF1α and increased FoxO3 expression.</div></div><div><h3>Conclusions</h3><div>In summary, this study demonstrates that ellagic acid inhibits PCSK9 by regulating HNF1α and FoxO3, thereby increasing LDLR levels and alleviating atherosclerosis. This finding not only consolidates the scientific basis of plant-based diets for preventing cardiovascular diseases but also provides an important direction for developing functional foods and nutritional intervention strategies based on natural polyphenols.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"134 ","pages":"Article 112717"},"PeriodicalIF":3.2,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143611211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intravenous Vitamin C in Critically Ill Adult Patients With Burns: An Integrative Review","authors":"Juan Novoa M.D. ,&nbsp;Gil Hardy Ph.D., F.R.S.C. ,&nbsp;Ignacio Aramendi M.D. ,&nbsp;William Manzanares Ph.D., M.D.","doi":"10.1016/j.nut.2025.112728","DOIUrl":"10.1016/j.nut.2025.112728","url":null,"abstract":"<div><div>Early fluid resuscitation may cause fluid overload in seriously ill burn patients, which is associated with losses of micronutrients and poor clinical outcomes. Over the past two to three decades, several animal studies and clinical trials have demonstrated that high-dose intravenous vitamin C may reduce fluid requirements, body weight gain, and wound edema, improving gas exchange and renal function in the acute phase after burn injury. Vitamin C is a scavenger of oxygen free radicals in the endothelium, which can limit the inflammatory response and ischemia–reperfusion injury, promoting wound healing. Nonetheless, current knowledge is not entirely conclusive. Research that leads to a better understanding of the vitamin's pharmacokinetics/dynamics is a first requirement before embarking on well-powered, well-designed clinical trials that still need to be conducted. This review aims to summarize vitamin C status in burn patients and its biological properties, in order to evaluate the rationale and most current evidence for routine supplementation, as recommended by current clinical guidelines, and the potential for high-dose vitamin C as a pharmaconutrient in critically ill burn patients.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"134 ","pages":"Article 112728"},"PeriodicalIF":3.2,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143611209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of vitamin D replacement therapy on 28 cases of myalgic encephalomyelitis/chronic fatigue syndrome after COVID-19 vaccination","authors":"Shinichiro Kodama M.D. ,&nbsp;Nafuko Konishi M.D., Ph.D. ,&nbsp;Yuriko Hirai B.A. ,&nbsp;Akinori Fujisawa M.D. ,&nbsp;Mitsuko Nakata Ph.D. ,&nbsp;Satoshi Teramukai Ph.D. ,&nbsp;Masanori Fukushima M.D., Ph.D.","doi":"10.1016/j.nut.2025.112718","DOIUrl":"10.1016/j.nut.2025.112718","url":null,"abstract":"<div><h3>Background</h3><div>Prolonged symptoms have been reported following both COVID-19 infection and vaccination, with some cases leading to myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Of 80 patients presenting to our hospital with postvaccination syndrome, 28 met the diagnostic criteria for ME/CFS. We conducted a retrospective study on these 28 patients.</div></div><div><h3>Methods</h3><div>We measured serum 25-hydroxyvitamin D levels in 28 patients who developed ME/CFS after COVID-19 vaccination between August 2022 and February 2024. Vitamin D replacement therapy included dietary counseling, sun exposure recommendations, and oral vitamin D supplementation. We evaluated changes in blood vitamin D levels and symptom improvement.</div></div><div><h3>Results</h3><div>At initial visit, 27 of 28 patients diagnosed with ME/CFS had insufficient or deficient serum 25-hydroxyvitamin D levels (16 ± 4 ng/mL, mean ± SD). Following vitamin D replacement therapy, we observed an increase in blood vitamin D levels (28 ± 5 ng/mL) associated with a decrease in ME/CFS diagnostic symptoms (from 10.3 ± 2.1 to 3.3 ± 2.0). Notably, 23 of 28 patients (82%) no longer met ME/CFS diagnostic criteria after the therapy. Among the symptoms, sleep problems showed the most improvement (71%), followed by autonomic symptoms (68%).</div></div><div><h3>Conclusions</h3><div>For patients developing ME/CFS after COVID-19 vaccination with insufficient or deficient vitamin D levels, appropriate vitamin D replacement therapy under medical guidance may lead to symptomatic relief. We are preparing a randomized controlled trial to evaluate the efficacy of vitamin D replacement therapy in individuals with ME/CFS who have developed vitamin D deficiency following COVID-19 infection or vaccination.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"134 ","pages":"Article 112718"},"PeriodicalIF":3.2,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143629400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between dietary B vitamin intakes and cognitive function among elderly individuals: An observational study","authors":"Qingshou Chen M.Med ,&nbsp;Jie Huang M.Med ,&nbsp;Xiaocong Shi M.Med ,&nbsp;Yuhui Peng M.Med ,&nbsp;Aixia Chen M.Med ,&nbsp;Lingling Huang M.Med ,&nbsp;Yuanfeng Zhang MD ,&nbsp;Xue Chen M.Med","doi":"10.1016/j.nut.2025.112716","DOIUrl":"10.1016/j.nut.2025.112716","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to investigate the associations between dietary B vitamin intakes and the prevalence of cognitive impairment among elderly individuals in the United States.</div></div><div><h3>Methods</h3><div>This cross-sectional analysis, based on data from 2716 participants aged 60 years or older in the National Health and Nutrition Examination Survey 2011 to 2014. Dietary intakes of six B vitamins (vitamins B1, B2, niacin, B6, total folate, and B12) were assessed using two 24-hour dietary recalls. Cognitive function was evaluated through the Consortium to Establish a Registry for Alzheimer's Disease word list learning test, the Animal Fluency Test, and the Digit Symbol Substitution Test. Associations between dietary B vitamin intakes and cognitive impairment were analyzed using multivariable logistic regression, restricted cubic spline regression, and weighted quantile sum regression.</div></div><div><h3>Results</h3><div>Higher dietary intakes of B vitamins were inversely associated with the prevalence of cognitive impairment. Participants in the highest quartile of intake showed reduced odds of cognitive impairment compared to the lowest quartile for vitamin B1 (OR = 0.53, 95% CI: 0.29–0.97), vitamin B2 (OR = 0.54, 95% CI: 0.29–1.02), niacin (OR = 0.32, 95% CI: 0.15–0.65), vitamin B6 (OR = 0.45, 95% CI: 0.26–0.79), total folate (OR = 0.53, 95% CI: 0.31–0.89), and vitamin B12 (OR = 0.48, 95% CI: 0.25–0.95). Restricted cubic spline analysis showed linear and inverse exposure-response relationships for all six vitamins without evidence of non-linearity. The weighted quantile sum regression indicated a combined protective effect of dietary B vitamins on cognitive impairment (OR = 0.76, 95% CI: 0.65–0.89), with niacin contributing most to the association (weight: 0.48).</div></div><div><h3>Conclusions</h3><div>Higher dietary B vitamin intakes may be linked to a lower prevalence of cognitive impairment among older adults in the US. These findings suggest that adequate consumption of dietary B vitamins may be beneficial for maintaining cognitive health. Further, longitudinal studies are needed to confirm these associations.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"134 ","pages":"Article 112716"},"PeriodicalIF":3.2,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143580775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fat mass is responsible for increased plasma and whole blood viscosity in obesity","authors":"Serpil Cecen MD ,&nbsp;Sena Ebru Caglar PhD ,&nbsp;Zozan Guleken PhD ,&nbsp;Yunus Karakoc PhD ,&nbsp;Seher Tanrıkulu PhD","doi":"10.1016/j.nut.2025.112714","DOIUrl":"10.1016/j.nut.2025.112714","url":null,"abstract":"<div><h3>Objectives</h3><div>Our study is centered around a pivotal question: How does the increase in adipose tissue, which defines obesity, impact hemorheological parameters? By delving into this question, we aim to underscore the crucial role of fat tissue increase in obesity, a topic of significant interest and importance in the field of physiology and obesity research.</div></div><div><h3>Methods</h3><div>Individuals with a body mass index (BMI) of 25 and above were included in this study. Height was measured with bare feet on flat surface, then, using the bioimpedance device (Tanita-BC418), weight, BMI, fat percentage, fat mass (FM), and fat-free mass were determined. Using the Brookfield viscometer, several shear rates were utilized (for whole blood, 75, 150, 300, and 450 sec^–1; for plasma 450 sec^–1) in accordance with established standards and test procedures. Whole blood and plasma viscosity were studied in Hamidiye Medical Faculty Hemorheology laboratory.</div></div><div><h3>Results</h3><div>Plasma viscosity in the obese group was significantly (<em>P</em> = 0.01) higher than in the non-obese group, and increased statistically in proportion to weight, BMI, FM, fat-free mass (<em>P</em> &lt; 0.05) in the obese group. At shear rates of 300 and 450 sec^–1 (<em>P</em> &lt; 0.05) were determined statistically significant differences between the obese and nonobese groups in whole blood viscosity (WBV). In the obese group, WBV at a shear rate of 75, 150, 300, and 450 sec^–1 showed a positive correlation with weight, BMI, FM (<em>P</em> &lt; 0.05).</div></div><div><h3>Conclusions</h3><div>Increased adipose tissue significantly affect plasma and blood viscosities in obesity. The increase in plasma and WBV is directly associated with the increase in adipose tissue.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"134 ","pages":"Article 112714"},"PeriodicalIF":3.2,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143580704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}