Nutrition最新文献

{"title":"Association between phase angle and body composition: new equations to predict fat mass and skeletal muscle mass","authors":"Daniel Rojano-Ortega ,&nbsp;Antonio Jesús Berral-Aguilar ,&nbsp;Heliodoro Moya-Amaya ,&nbsp;Antonio Molina-López ,&nbsp;Francisco José Berral-de la Rosa","doi":"10.1016/j.nut.2025.112772","DOIUrl":"10.1016/j.nut.2025.112772","url":null,"abstract":"<div><h3>Objective</h3><div>The aim of this cross-sectional study was to develop new regression equations for estimating fat mass (FM) and skeletal muscle mass (SMM) in a heterogeneous Caucasian population, using the phase angle (PhA) as a bioelectrical parameter and DXA as the reference method. We also aimed to cross-validate the new equations, and to compare them with the manufacturers’ equations.</div></div><div><h3>Methods</h3><div>The 212 healthy Caucasian participants aged 20–65 years were randomly distributed into two groups: development group (n = 141) and validation group (n = 71). Bioelectrical parameters were obtained with a 50 kHz foot-to-hand phase-sensitive body composition analyzer. The new FM percentage (FM%) and SMM percentage (SMM%) equations were developed by performing multiple forward regression analyses. Agreement between DXA and the different equations was assessed by mean differences, coefficient of determination, standard error of the estimate (SEE), concordance correlation coefficient (CCC), and Bland–Altman plots.</div></div><div><h3>Results</h3><div>The proposed equations explained 89.2% of the variance in the DXA-derived FM% and 91.8% in the DXA-derived SMM%, with low random errors (SEE = 3.04% and 1.92%, respectively), and a very strong agreement (CCC = 0.93 and 0.94, respectively). In addition, they demonstrated no fixed bias and a relatively low individual variability. However, the manufacturer's equations described a lower percentage of the variance, with higher random errors, obtained fixed bias of -5.77% for FM% and 4.91% for SMM%, as well as higher individual variability.</div></div><div><h3>Conclusions</h3><div>The new regression equations, which include the PhA as a bioelectrical parameter, can accurately predict DXA-derived FM% and SMM% in a heterogeneous Caucasian population, and are better options than the manufacturer's equations.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"135 ","pages":"Article 112772"},"PeriodicalIF":3.2,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of integrative telehealth-based nutrition care with and without oral nutritional supplements in patients with liver and colorectal cancer: A randomized controlled trial","authors":"Wei-Chun Chang M.S. ,&nbsp;Ming-Shun Wu M.D. ,&nbsp;Yi-Hsiu Chen M.S. ,&nbsp;Suh-Ching Yang Ph.D.","doi":"10.1016/j.nut.2025.112768","DOIUrl":"10.1016/j.nut.2025.112768","url":null,"abstract":"<div><h3>Objectives</h3><div>This study investigated the effects of post-discharge integrative telehealth-based nutritional care alone versus post-discharge integrative telehealth-based nutritional care combined with high-calorie/high-protein oral nutritional supplements (HCHP-ONS) on the nutritional status and quality of life in patients with hepatocellular carcinoma (HCC) or colorectal cancer (CRC) at risk of malnutrition.</div></div><div><h3>Methods</h3><div>We recruited HCC or CRC patients who were at moderate to high risk of malnutrition, defined as a score of 4–9 on the abridged Patient-Generated Subjective Global Assessment (aPG-SGA), and randomly assigned them to either a telehealth nutritional care-control group (C group) or a telehealth nutritional care combined with HCHP-ONS group (C+O group) for a 3-month intervention. In group C, a dietitian provided monthly telehealth-based nutritional assessments and guidance through a mobile application (LINE) or phone calls. In the C+O group, in addition to telehealth-based nutritional assessments and guidance, patients received a daily can of HCHP-ONS, which provided 425 kcal and 19.1 g of protein per serving. Blood tests, anthropometric indicators, the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) and a nutritional status assessment were conducted monthly.</div></div><div><h3>Results</h3><div>Results showed that the C+O group had significantly reduced malnutrition risk scores at the 1^st, 2^nd, and 3^rd months. By the 3^rd month, the C+O group showed significant improvement in the Prognostic Nutritional Index (PNI), and notable improvements in diarrhea and respiratory distress scores.</div></div><div><h3>Conclusions</h3><div>In patients with HCC and CRC who were at risk of malnutrition, integrative telehealth-based nutritional care via LINE or phone calls effectively reduced malnutrition risk, maintained PNI, and supported quality of life (QOL). The addition of HCHP-ONS further enhanced nutritional outcomes, leading to greater improvements in PNI, diarrhea, and dyspnea by the 3^rd month.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"135 ","pages":"Article 112768"},"PeriodicalIF":3.2,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The mediating role of perceived social isolation in feeding methods and depression among patients with dysphagia after ischemic stroke: A multicenter study","authors":"Hongji Zeng M.Med. ,&nbsp;Jing Zeng B.S. ,&nbsp;Weijia Zhao M.Med. ,&nbsp;Yuzhen Qin Ph.D. ,&nbsp;Changming Wen Ph.D. ,&nbsp;Xi Zeng Ph.D.","doi":"10.1016/j.nut.2025.112769","DOIUrl":"10.1016/j.nut.2025.112769","url":null,"abstract":"<div><h3>Background</h3><div>Feeding methods may influence post stroke depression. Perceived social isolation may mediate this underlying mechanism. In this study we explored the effects of perceived social isolation on the relationship between feeding methods and post stroke depression.</div></div><div><h3>Methods</h3><div>This observational study was conducted between 2022 and 2024. The subjects were ischemic stroke survivors with dysphagia. Information was collected, including 1) depression levels (Patient Health Questionnaire-9 items [PHQ-9]), 2) demographic characteristics, 3) clinical conditions, 4) treatment details, and 5) perceived social isolation. After matching the baseline and treatment-related variables, a mediation model was used to analyze the relationship among perceived social isolation, feeding methods, and depression levels.</div></div><div><h3>Results</h3><div>There were 2764 participants (44.54% using Nasogastric Tube feeding [NGT]). Before matching, the PHQ-9 score for all participants on day 10 was significantly lower than that at admission (<em>P</em> &lt; 0.001). After matching confounding factors, the PHQ-9 score on day 10 for the Intermittent Oro-Esophageal tube feeding (IOE) users was significantly lower than that of the NGT users [(7.03 ± 2.52) versus (9.25 ± 5.55), n1 = n2 = 800, <em>P</em> &lt; 0.001]. The mediation model showed that 1) compared to NGT, IOE can cause significantly lower perceived social isolation on day 10 (effect = 5.808, <em>P</em> &lt; 0.001); 2) compared to NGT, IOE can significantly lower depression levels on day 10 (effect = 0.180, <em>P</em> &lt; 0.001); and (3) perceived social isolation showed partial mediating effects, and the proportion of the mediation effect was 47.19% (1.046/2.218, <em>P</em> &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>Compared to NGT, IOE can significantly improve post stroke depression levels. Perceived social isolation mediated the relationship between feeding methods and post stroke depression.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"135 ","pages":"Article 112769"},"PeriodicalIF":3.2,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143806851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Turkish validity and reliability of the Four Facet Mindful Eating Scale (FFaMES-TR) in adolescence","authors":"Neslihan Sürmeli Akçadağ MD ,&nbsp;Saniye Bilici PhD","doi":"10.1016/j.nut.2025.112770","DOIUrl":"10.1016/j.nut.2025.112770","url":null,"abstract":"<div><h3>Objectives</h3><div>The aim of this study was to evaluate the validity and reliability of the Four Facet Mindful Eating Scale by Carrière et al. in a Turkish adolescent group.</div></div><div><h3>Methods</h3><div>The study included 591 participants between 14 and 17 years old. The Cronbach's alpha (CA) coefficient was used to evaluate the internal consistency reliability and the test-retest method was applied. Exploratory factor analysis (EFA) was performed to determine the factor structure. The model obtained with EFA was evaluated with confirmatory factor analysis.</div></div><div><h3>Results</h3><div>The total CA of the scale was 0.893, non-reactance CA 0.898, external awareness 0.808, non-judgment 0.862, internal awareness 0.772. The relationships between the total score and subscales in the first test and retest were found to be significant (<em>P</em> &lt; 0.001). The Kaiser–Meyer–Olkin value was 0.903. Bartlett's test of sphericity, the correlation level between the items was found to be sufficient for factor analysis (<em>χ</em>^2 = 5326.27, standard deviation = 231, <em>P</em> = 0.001; <em>P</em> &lt; 0.05). The factor loadings of the items were between 0.511 and 0.885, and the factors explained 61.8% of the variance. It was observed that the model had an acceptable fit (<em>χ</em>²/standard deviation 3.035, comparative fit index 0.933, Tucker–Lewis index 0.904, standardized root mean square error 0.057, and root mean square error of approximation 0.058. Because of applying EFA to the 29 questions in the scale, it was decided to remove 8 items from the final scale.</div></div><div><h3>Conclusions</h3><div>The Turkish version of the Four Facet Mindful Eating Scale is valid and reliable for assessing mindful eating behaviors among adolescents.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"135 ","pages":"Article 112770"},"PeriodicalIF":3.2,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143828463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between body composition parameters and quality of life in patients with obesity and osteoarthritis","authors":"Jaime González-Gutiérrez MD ,&nbsp;Juan José López-Gómez MD, PhD ,&nbsp;David Primo-Martín MD, PhD ,&nbsp;Olatz Izaola-Jauregui MD, PhD ,&nbsp;Beatriz Ramos-Bachiller MD, PhD ,&nbsp;Rebeca Jiménez-Sahagún MD, PhD ,&nbsp;Daniel A. De Luis-Román MD, PhD","doi":"10.1016/j.nut.2025.112765","DOIUrl":"10.1016/j.nut.2025.112765","url":null,"abstract":"<div><h3>Background and aims</h3><div>The aim of this study was to evaluate the relationship between body composition determined by bioimpedanciometry (BIA) with quality of life (QoL) and functional capacity in patients with obesity and chronic osteoarthritis.</div></div><div><h3>Methods</h3><div>The design was a descriptive cross-sectional study in a sample of 467 patients (350 women and 117 men) with obesity and chronic osteoarthritis. Age, sex, body mass index (BMI), QoL WOMAC test (expressed as a percentage from total score) and BIA parameters (muscle mass index (MMI), fat mass index (FMI), phase angle (PA), BMI-adjusted PA, reactance (Xc) and resistance (RZ)) were recorded. Patients were divided according to total WOMAC score in four quartiles.</div></div><div><h3>Results</h3><div>The mean age of the patients was 60.12 (10.87) years and 74.9% of the patients were women. The mean BMI was 40.14 (5.39) kg/m2 (M: 39.74 (5.52) vs. W: 40.27 (5.35) kg/m2, <em>P =</em> 0.36). Total WOMAC scores were 49.12 (22.15) % (M: 46.40 (21.58) vs. W: 51.10 (22.25)%, <em>P &lt;</em> 0.05); for stiffness, the score was 47.73% (M: 44.35 (30.36) vs. W: 48.85 (28.45)%, <em>P =</em> 0.15); for pain, it was 52.26 (25.34)% (M: 50.73 (32.68) vs. W: 52.77 (22.39)%, <em>P =</em> 0.45); and for functional capacity, it was 49.07 (23.38)% (M: 45.48 (23.18) vs. W: 50.27 (23.35)%, <em>P =</em> 0.06). MMI and BMI-adjusted PA were negatively correlated with WOMAC functional capacity score (r = –0.16, <em>P &lt;</em> 0.05 for both sexes).</div></div><div><h3>Conclusions</h3><div>In patients with obesity and chronic osteoarthritis, muscle mass determined by bioimpedanciometry could have a relationship with quality of life determined by the WOMAC test. The decrease in the phase angle adjusted by BMI was related to a slightly decrease in the quality of life.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"135 ","pages":"Article 112765"},"PeriodicalIF":3.2,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143821093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between muscle mass assessed by an artificial intelligence–based ultrasound imaging system and quality of life in patients with cancer-related malnutrition","authors":"Daniel de Luis M.D. ,&nbsp;Angela Cebria M.D. ,&nbsp;David Primo M.D. ,&nbsp;Olatz Izaola M.D. ,&nbsp;Eduardo Jorge Godoy Ph.D. ,&nbsp;Juan Jose Lopez Gomez M.D.","doi":"10.1016/j.nut.2025.112763","DOIUrl":"10.1016/j.nut.2025.112763","url":null,"abstract":"<div><h3>Introduction</h3><div>Emerging evidence suggests that diminished skeletal muscle mass is associated with lower health-related quality of life (HRQOL) in individuals with cancer. There are no studies that we know of in the literature that use ultrasound system to evaluate muscle mass and its relationship with HRQOL.</div></div><div><h3>Objective</h3><div>The aim of our study was to evaluate the relationship between HRQOL determined by the EuroQol-5D tool and muscle mass determined by an artificial intelligence–based ultrasound system at the rectus femoris (RF) level in outpatients with cancer.</div></div><div><h3>Material and methods</h3><div>Anthropometric data by bioimpedance (BIA), muscle mass by ultrasound by an artificial intelligence–based at the RF level, biochemistry determination, dynamometry and HRQOL were measured.</div></div><div><h3>Results</h3><div>A total of 158 patients with cancer were included with a mean age of 70.6 ±9.8 years. The mean body mass index was 24.4 ± 4.1 kg/m² with a mean body weight of 63.9 ± 11.7 kg (38% females and 62% males). A total of 57 patients had a severe degree of malnutrition (36.1%). The distribution of the location of the tumors was 66 colon-rectum cancer (41.7%), 56 esophageal-stomach cancer (35.4%), 16 pancreatic cancer (10.1%), and 20.2% other locations. A positive correlation cross-sectional area (CSA), muscle thickness (MT), pennation angle, (BIA) parameters, and muscle strength was detected. Patients in the groups below the median for the visual scale and the EuroQol-5D index had lower CSA and MT, BIA, and muscle strength values. CSA (beta 4.25, 95% CI 2.03–6.47) remained in the multivariate model as dependent variable (visual scale) and muscle strength (beta 0.008, 95% CI 0.003–0.14) with EuroQol-5D index. Muscle strength and pennation angle by US were associated with better score in dimensions of mobility, self-care, and daily activities.</div></div><div><h3>Conclusion</h3><div>CSA, MT, and pennation angle of RF determined by an artificial intelligence–based muscle ultrasound system in outpatients with cancer were related to HRQOL determined by EuroQol-5D.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"135 ","pages":"Article 112763"},"PeriodicalIF":3.2,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143855002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are plant-based and omnivorous diets the same for muscle hypertrophy? A narrative review of possible challenges of plant-based diets in resistance-trained athletes","authors":"Damoon Ashtary-Larky","doi":"10.1016/j.nut.2025.112742","DOIUrl":"10.1016/j.nut.2025.112742","url":null,"abstract":"<div><div>This narrative review examines the potential challenges associated with plant-based diets in supporting muscle hypertrophy among resistance-trained athletes. Contrary to common assumptions, current evidence suggests that plant-based diets, when properly planned, can provide protein comparable to omnivorous diets. However, plant-based proteins are generally considered less anabolic due to lower digestibility, essential amino acid (EAA) content, and particularly lower leucine levels. The review discusses challenges and solutions for athletes aiming to maximize hypertrophy through plant-based diets, while highlighting the need for more robust research on advanced resistance-trained athletes.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"135 ","pages":"Article 112742"},"PeriodicalIF":3.2,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143806850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the association between human breast milk lipids and early adiposity rebound in children: a case-control study","authors":"Kento Sawane ,&nbsp;Ippei Takahashi ,&nbsp;Mami Ishikuro ,&nbsp;Hiroko Takumi ,&nbsp;Masatsugu Orui ,&nbsp;Aoi Noda ,&nbsp;Genki Shinoda ,&nbsp;Hisashi Ohseto ,&nbsp;Tomomi Onuma ,&nbsp;Fumihiko Ueno ,&nbsp;Keiko Murakami ,&nbsp;Naoko Higuchi ,&nbsp;Takashi Furuyashiki ,&nbsp;Tomohiro Nakamura ,&nbsp;Seizo Koshiba ,&nbsp;Kinuko Ohneda ,&nbsp;Kazuki Kumada ,&nbsp;Soichi Ogishima ,&nbsp;Atsushi Hozawa ,&nbsp;Junichi Sugawara ,&nbsp;Taku Obara","doi":"10.1016/j.nut.2025.112739","DOIUrl":"10.1016/j.nut.2025.112739","url":null,"abstract":"<div><h3>Objectives</h3><div>Adiposity rebound (AR) corresponds to the start of the second rise in the body mass index (BMI) curve during infant growth. Early AR (before age 5) confers increased risk of adiposity and metabolic disorders but is less likely to occur in breastfed infants. Although lipids in breast milk is important in child growth, information is limited regarding which lipids involve in AR. The object of this study was to explore breast milk lipids associated with the AR status in children.</div></div><div><h3>Methods</h3><div>We designed a case-control study of 184 mother–child pairs (AR cases: n = 93; controls: n = 91) included from the Tohoku Medical Megabank Project Birth and Three-Generation (TMM BirThree) Cohort Study. Breast milk was collected one month postpartum and comprehensive lipid analysis was performed. Partial least square-discriminant analysis (PLS-DA) was used to explore candidate lipids, and multivariable logistic regression analysis was used to evaluate associations with the AR status of children.</div></div><div><h3>Results</h3><div>We detected 667 lipid molecules in 12 lipid classes in breast milk. PLS-DA revealed an association of fatty acid-hydroxy fatty acid (FAHFA) and cholesterol ester (ChE) with AR status. Multivariable logistic regression analysis showed that, in pairs with exclusive breastfeeding at one month postpartum, FAHFA (OR 1.57 [95% CI, 1.06–2.32]) was positively associated with early AR, and ChE (OR 0.55 [95% CI, 0.36–0.86]) was negatively associated.</div></div><div><h3>Conclusions</h3><div>Breast milk lipids (FAHFA, ChE) associated with the AR status of children, indicating the potential to regulate child's adiposity and possible metabolic disorders in adulthood.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"135 ","pages":"Article 112739"},"PeriodicalIF":3.2,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143821025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex differences in fruit and vegetable consumption: Impact of menopausal transition on dietary choices.","authors":"Anna Vittoria Mattioli","doi":"10.1016/j.nut.2025.112741","DOIUrl":"https://doi.org/10.1016/j.nut.2025.112741","url":null,"abstract":"","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":" ","pages":"112741"},"PeriodicalIF":3.2,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship of phase angle with postoperative pneumonia and survival prognosis in patients with esophageal cancer: A retrospective cohort study","authors":"Sanshiro Kawata M.D., Ph.D. ,&nbsp;Eisuke Booka M.D., Ph.D. ,&nbsp;Junko Honke ,&nbsp;Ryoma Haneda M.D., Ph.D. ,&nbsp;Wataru Soneda M.D. ,&nbsp;Tomohiro Murakami M.D., Ph.D. ,&nbsp;Tomohiro Matsumoto M.D., Ph.D. ,&nbsp;Yoshifumi Morita M.D., Ph.D. ,&nbsp;Hirotoshi Kikuchi M.D., Ph.D. ,&nbsp;Yoshihiro Hiramatsu M.D., Ph.D. ,&nbsp;Hiroya Takeuchi M.D., Ph.D","doi":"10.1016/j.nut.2025.112743","DOIUrl":"10.1016/j.nut.2025.112743","url":null,"abstract":"<div><h3>Objectives</h3><div>Phase angle (PhA), derived from bioelectrical impedance analysis (BIA), is an indicator of cell membrane health. Low PhA values reflect poor cellular function and low muscle mass. However, consensus regarding the appropriate cutoff value of PhA remains insufficient, and its impact on outcomes after esophagectomy in patients with esophageal malignancies is not well studied. We aimed to investigate whether preoperative PhA is associated with postoperative complication risk and survival prognosis and whether PhA decrease during the surgical preparation period is a prognostic factor in patients with esophageal cancer.</div></div><div><h3>Methods</h3><div>This retrospective cohort study analyzed data from 194 patients who had undergone esophagectomy for esophageal malignancies. A PhA measured several days before surgery, with cutoff values of 5.0° for men and 4.2° for women, was used. The relationship between postoperative pneumonia and clinicopathological factors and between low PhA and postoperative outcomes and survival prognosis was investigated. The preoperative PhA decline and survival prognosis were analyzed in 134 patients whose PhA was measured twice before surgery.</div></div><div><h3>Results</h3><div>Overall, 93 and 101 patients were classified into the low and high PhA groups, respectively. A multivariate analysis showed that a serum albumin level lower than 3.5 g/dL and low PhA were independent risk factors for pneumonia (odds ratio [OR] = 3.40, <em>P</em> = 0.03; OR = 3.42, <em>P</em> = 0.03, respectively). The low PhA group exhibited significantly higher intraoperative fluid balance (6.7 versus 6.0 mL/kg/h, <em>P</em> = 0.01) and a higher proportion of patients who failed to achieve early mobilization on the first postoperative day (46 versus 32%, <em>P</em> = 0.04) than did the high PhA group. Multivariate analysis using a Cox proportional hazards model revealed that low PhA was a poor survival prognostic factor, independent of the clinical stage of esophageal cancer (hazard ratio = 2.61, <em>P</em> &lt; 0.01). In patients whose PhA was measured twice preoperatively, a decrease in PhA during the preoperative period was a significant indicator of poor survival (hazard ratio = 2.59, <em>P</em> &lt; 0.01). The group with a decrease in PhA during the preoperative period had significantly fewer steps than the group with an increase in PhA (6220 ± 2880 versus 8200 ± 2850, <em>P</em> &lt; 0.01).</div></div><div><h3>Conclusions</h3><div>Low PhA was a risk factor for postoperative pneumonia in patients who had undergone esophagectomy and was associated with poor survival prognosis. A decrease in PhA during the preoperative period was a significant poor prognostic factor. Increasing physical activity before surgery may lead to an increase in PhA. Thus, it is important to measure and evaluate PhA changes sequentially in patients with esophageal cancer.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"135 ","pages":"Article 112743"},"PeriodicalIF":3.2,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143799659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}