Nutrition最新文献

{"title":"A triad strategy of rehabilitation, nutrition, and oral management for malnutrition, sarcopenia, and frailty in super-aged societies","authors":"Yoshihiro Yoshimura M.D., Ph.D. ,&nbsp;Hidetaka Wakabayashi M.D., Ph.D. ,&nbsp;Ayaka Matsumoto R.Ph. ,&nbsp;Fumihiko Nagano R.P.T. ,&nbsp;Sayuri Shimazu R.D. ,&nbsp;Ai Shiraishi R.D.H.","doi":"10.1016/j.nut.2025.112959","DOIUrl":"10.1016/j.nut.2025.112959","url":null,"abstract":"<div><h3>Background</h3><div>Rapid population aging has intensified the prevalence of malnutrition, sarcopenia, frailty, and oral dysfunction, significantly affecting healthcare outcomes and quality of life in older adults. A growing body of evidence suggests that integrating rehabilitation, nutrition support, and oral health management—a “triad” approach—may yield superior clinical outcomes compared to isolated interventions.</div></div><div><h3>Objective</h3><div>This narrative review synthesizes existing research on this integrated approach, highlighting its theoretical foundation, clinical implications, and implementation strategies.</div></div><div><h3>Results</h3><div>Evidence underscores that combined multidisciplinary interventions yield superior outcomes compared to single-domain approaches by effectively improving muscle mass, swallowing function, activities of daily living, and nutritional status. Recent policy developments, such as those in Japan, endorse this triad approach, reflecting its growing recognition; however, significant barriers to widespread clinical implementation remain.</div></div><div><h3>Conclusion</h3><div>The triad approach is a promising cornerstone of modern geriatric care. Future research should focus on optimizing intervention delivery, overcoming implementation barriers, such as challenges in interdisciplinary coordination, and assessing long-term outcomes to firmly establish this approach within comprehensive care systems as a cornerstone of geriatric healthcare.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"142 ","pages":"Article 112959"},"PeriodicalIF":3.0,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145302487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Partial substitution of ketogenic diet therapy with a blended diet: Evaluation of clinical practice in neurologically impaired fully tube fed children","authors":"Monica Guglielmetti R.D., Ph.D. ,&nbsp;Marit Verhagen R.D. ,&nbsp;Esther van Steenbergen R.D., Ph.Dst. ,&nbsp;Sarita van den Berg M.Sc. ,&nbsp;Suzanna Koudijs M.D. ,&nbsp;Barbara de Koning M.D., Ph.D. ,&nbsp;Elles van der Louw R.D., Ph.D.","doi":"10.1016/j.nut.2025.112956","DOIUrl":"10.1016/j.nut.2025.112956","url":null,"abstract":"<div><h3>Background and Aim</h3><div>Gastrointestinal (GI) symptoms are common in neurologically impaired, tube-fed patients and may impact quality of life. A blended diet (BD) might reduce these symptoms. This study evaluated whether replacing one daily portion of a ketogenic diet therapy (KDT) regimen with BD could improve GI complaints in gastrostomy-fed children with severe neurological impairment and drug-resistant epilepsy.</div></div><div><h3>Methods</h3><div>Children (1–18 y) on KDT with recurrent GI complaints were included, along with two historical cases. Over 3 mo, one daily BD portion replaced standard KDT formula. Data on GI, neurological, nutritional, and anthropometric parameters were collected. Feasibility and well-being were assessed, and parents participated in interviews. Ethical approval was granted (MEC-2023-0557).</div></div><div><h3>Results</h3><div>Nine patients (6 males, 3 females; median age 9 y) participated; six completed the study. BD was introduced over 2–4 wk. Two patients reduced laxative use by half, one improved stool frequency (from several times/d to once/d), and one historical case reported fewer hospital visits. Promotility medications remained unchanged. All six completers adhered to one BD portion and continued its use. Seizure frequency improved in two cases (33.3%). No significant changes occurred in other parameters.</div></div><div><h3>Conclusions</h3><div>Replacing just one KDT portion with BD improved GI symptoms and was feasible even in severely impaired children. It did not compromise ketosis or dietary effectiveness. Partial BD may be considered early in managing persistent GI issues during KDT, but should be personalized and carefully monitored.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"142 ","pages":"Article 112956"},"PeriodicalIF":3.0,"publicationDate":"2025-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145302533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of ChatGPT-3.5, ChatGPT-40 and DeepSeek in generating dietary plans for patients with chronic kidney disease: A focus on nutritional accuracy and dietary inflammation","authors":"Qian You M.S.,&nbsp;Linhua Zhou M.M.,&nbsp;Ya Ma M.M.,&nbsp;Jiankui Guo M.M.,&nbsp;Yi Wang B.S.,&nbsp;Lei Shi Ph.D.,&nbsp;Yanru Deng B.S.,&nbsp;Zhiyong Rao Ph.D.,&nbsp;Xuemei Li M.M.","doi":"10.1016/j.nut.2025.112957","DOIUrl":"10.1016/j.nut.2025.112957","url":null,"abstract":"<div><h3>Background</h3><div>Our previous research indicated that ChatGPT-3.5 was inadequate in generating nutritionally accurate dietary plans for patients with chronic kidney disease (CKD). Given the subsequent release of ChatGPT-40 and the emergence of DeepSeek, the aim of this study is to assess and compare the CKD dietary plans generated by ChatGPT-3.5, ChatGPT-4.0, and DeepSeek in terms of both nutritional accuracy and the Dietary Inflammatory Index (DII).</div></div><div><h3>Methods</h3><div>Standardized dietary prescription prompts with a fixed energy target of 1800 kcal and five protein levels (30 g, 40 g, 50 g, 60 g, and 70 g) were designed to represent different stages of CKD. Twenty participants were recruited and instructed to input these pre-established prompts into the three LLMs to generate renal diets. The actual energy and protein contents of the resulting meal plans were recorded and compared across the three models. The DII values were calculated based on the USDA database.</div></div><div><h3>Results</h3><div>A total of 300 meal plans were generated. All three LLMs failed to meet the 1800 kcal energy target, with values ranging from 1165 to 1548 kcal (<em>P</em> &lt; 0.001). DeepSeek generated plans that were closest to the target energy and protein levels. ChatGPT-4.0 generated the most anti-inflammatory plans (DII = −1.487335), followed by ChatGPT-3.5 (DII = −0.9163290); whereas DeepSeek (DII = 2.2502160) produced pro-inflammatory plans.</div></div><div><h3>Conclusion</h3><div>This study confirmed the limitations of LLMs in generating nutritionally accurate dietary plans for patients with CKD. DeepSeek outperformed the ChatGPT models in nutritional accuracy, whereas the ChatGPT models generated more anti-inflammatory diets. As AI evolves, human oversight remains crucial in ensuring the safety and efficacy of AI-generated dietary plans.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"142 ","pages":"Article 112957"},"PeriodicalIF":3.0,"publicationDate":"2025-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145364766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “The Effect of Mediterranean Diet Adherence During the Third Trimester of Pregnancy on Maternal and Newborn Health Outcomes” Nutrition 140 (2025) 112909 1-10","authors":"Jiyan Aslan Ceylan","doi":"10.1016/j.nut.2025.112929","DOIUrl":"10.1016/j.nut.2025.112929","url":null,"abstract":"","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"140 ","pages":"Article 112929"},"PeriodicalIF":3.0,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145065186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural histone deacetylase inhibitions from legumes: Exploring epigenetics modulation through systems biology","authors":"Amber Rizwan MSc ,&nbsp;Aatiquah Aqeel MSc ,&nbsp;Furqan Choudhary MSc ,&nbsp;Anam Nizam MSc ,&nbsp;Asiya Khan MSc ,&nbsp;Humaira Farooqi PhD","doi":"10.1016/j.nut.2025.112955","DOIUrl":"10.1016/j.nut.2025.112955","url":null,"abstract":"<div><div>Epigenetic regulation, particularly histone deacetylases (HDACs), is critical for gene expression, chromatin remodeling, and cellular function. While synthetic HDAC inhibitors (HDACi) have shown promise in cancer treatment, their clinical utility is frequently constrained by toxicity, poor isoform specificity, and inferior performance in solid tumors. In recent years, there has been a rising focus on natural chemicals, particularly (poly)phenols produced from legumes, as safer and more selective alternatives. This review comprehensively examines the existing literature on legume-derived (poly)phenols, including genistein, daidzein, quercetin, and kaempferol, and their role as natural HDACis. It discusses their chemical diversity, HDAC inhibitory mechanisms, epigenetic influence, and associated biological activities such as anti-inflammatory, anticancer, and neuroprotective properties. In vitro and in vivo research on HDAC regulation by legume (poly)phenols are rigorously explored, as well as comparative insights into synthesized HDACi. This article also covers bioavailability issues, metabolism, and formulation options for improving therapeutic efficacy; highlights the therapeutic potential of legume (poly)phenols as epigenetic modulators by combining findings from molecular, pharmacological, and nutritional investigations: and calls for additional research into their use in nutraceutical development and disease treatment.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"142 ","pages":"Article 112955"},"PeriodicalIF":3.0,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145302480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut microbiota biomarkers enable stratified nutritional approaches for functional constipation subtypes in children with comorbidities","authors":"Congfu Huang M.Sc. ,&nbsp;Chunyan Wang M.Sc. ,&nbsp;Bin Wu M.Sc. ,&nbsp;Wei Kong M.Sc. ,&nbsp;Lingyu Wan M.Sc. ,&nbsp;Hui Wu M.Sc. ,&nbsp;Ying Huang M.Sc. ,&nbsp;Xing Wang M.Sc. ,&nbsp;Yongmei Zeng M.D. ,&nbsp;Haiying Liu M.D.","doi":"10.1016/j.nut.2025.112949","DOIUrl":"10.1016/j.nut.2025.112949","url":null,"abstract":"<div><h3>Background</h3><div>Functional constipation (FC) in children with comorbidities (allergic rhinitis [AR], food allergy [FA], neurodevelopmental disorders [DD]) exhibits distinct gut microbiota (GM) alterations, but their implications for comorbidity-tailored nutrition remain unexplored.</div></div><div><h3>Methods</h3><div>In this cross-sectional study, 127 children (&lt;6 years) were stratified into: isolated FC (CP, n = 15), FC+AR (CPAR, n = 57), FC + FA (CPFA, n = 30), FC+DD (CPDD, n = 25), and healthy controls (CK, n = 59). Fecal 16S rRNA sequencing (V3–V4) combined with dietary assessment (24-h recall + validated FFQ) identified GM biomarkers and diet-microbe interactions.</div></div><div><h3>Results</h3><div>All FC subtypes showed depleted short-chain fatty acid (SCFA)-producers (<em>Faecalibacterium, Phascolarctobacterium</em>; log₂ fold change [log₂FC] = −3.2 to −2.3, q &lt; 0.001). Comorbidity-specific signatures were: 1) CPFA: ↑<em>Enterococcus</em> (4.2× <em>versus</em> CPAR, q = 0.009), inversely correlating with animal protein avoidance (<em>Ρ</em> = −0.62, <em>P = 0.</em>01); 2) CPDD: ↑<em>Blautia</em> (log₂FC=1.6, q=0.002) with preserved α-diversity; 3) CPAR: ↓<em>Subdoligranulum</em> (LDA = 4.9, q &lt; 0.0001) and upregulated NOD-like receptor signaling.</div></div><div><h3>Conclusion</h3><div>We propose the first GM-guided framework for stratified nutritional interventions for pediatric FC: 1)Inflammatory subtypes (CPAR/CPFA): SCFA-producers (e.g., <em>Clostridium butyricum</em>) + high-fiber diet + vitamin A fortification (500μg RE/day); 2)Neurodevelopmental FC (CPDD): Gut-brain axis modulators + safety-optimized probiotics; 3)Isolated FC: Fiber-focused dietary optimization.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"141 ","pages":"Article 112949"},"PeriodicalIF":3.0,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145302504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of a self-administered web-based 24-h dietary recall for individuals with severe obesity undergoing bariatric surgery","authors":"Sarah-Kim Ross RD ,&nbsp;Amélie Lachance RD, MSc ,&nbsp;Marianne Legault RD, MSc ,&nbsp;Mélissa Pelletier MSc ,&nbsp;Vicky Leblanc RD, PhD ,&nbsp;Catherine Laramée RD, MSc ,&nbsp;Laurent Biertho MD ,&nbsp;Anne-Sophie Morisset RD, PhD ,&nbsp;Stéphanie Harrison RD, PhD ,&nbsp;Benoît Lamarche PhD ,&nbsp;Simone Lemieux RD, PhD ,&nbsp;Andréanne Michaud RD, PhD","doi":"10.1016/j.nut.2025.112953","DOIUrl":"10.1016/j.nut.2025.112953","url":null,"abstract":"<div><h3>Aim</h3><div>The study aimed to assess the validity of a web-based 24-h recall (R24W) for measuring dietary intakes in individuals living with severe obesity who are awaiting bariatric surgery, compared to a food record (FR), currently used in clinical settings.</div></div><div><h3>Methods</h3><div>A total of 51 individuals with severe obesity awaiting bariatric surgery were recruited (mean age: 45.3 ± 8.0 years). Before surgery, participants completed three R24W and a 3-day FR. Nutritional intakes were derived from the 2015 version of the Canadian Nutrient File. Mean differences in energy and nutrient intakes were assessed using percent differences and paired <em>t</em>-tests. Spearman correlations evaluated the associations between tools, while cross-classification analyses, weighted kappa scores, and Bland-Altman analyses were used to assess the degree of agreement. To determine validity, a seven-criterion validity analysis proposed by Lombard et al. was applied. The R24W was considered valid if it had three or fewer poor scores.</div></div><div><h3>Results</h3><div>Energy, carbohydrates, proteins, fats, saturated fat, dietary fiber, vitamin B6, vitamin B12, vitamin C, vitamin D, calcium, iron, magnesium, potassium, and sodium had three or fewer poor scores, suggesting that the R24W provides an estimation of these nutrient intakes similar to the FR. In contrast, vitamin A, riboflavin, thiamin, folate, niacin, and phosphorus scored below the threshold of poor scores.</div></div><div><h3>Conclusion</h3><div>The R24W demonstrated good validity for assessing energy intake, macronutrients, and several key nutrients (e.g., iron and vitamin D) in this population. These findings support the use of the R24W as a clinical and valid tool for dietary assessment in the bariatric population.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"142 ","pages":"Article 112953"},"PeriodicalIF":3.0,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145313237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lean tissue index and nutritional status in dialysis patients: Insights from a large-scale observational study","authors":"Georgios Kosmadakis M.D., Ph.D.,&nbsp;Aura Necoara M.D.,&nbsp;Julien Baudenon M.D.,&nbsp;Clemence Deville M.D.,&nbsp;Ioana Enache M.D., Ph.D.,&nbsp;Fatima El Kanouni M.D.,&nbsp;Joseph El Hajal M.D.","doi":"10.1016/j.nut.2025.112951","DOIUrl":"10.1016/j.nut.2025.112951","url":null,"abstract":"<div><h3>Objectives</h3><div>Malnutrition and lean tissue loss are common in dialysis patients and are linked to increased morbidity and mortality. Lean Tissue Index (LTI), a measure of muscle mass adjusted for height, offers an objective assessment of nutritional status. However, its relationship with conventional nutritional markers remains poorly defined.</div></div><div><h3>Methods</h3><div>We conducted a retrospective analysis of 365 adult dialysis patients from multiple centers. Baseline data included anthropometrics, body composition (LTI), and nutritional biomarkers: albumin, prealbumin, Geriatric Nutritional Risk Index (GNRI), normalized protein catabolic rate, phosphate, and potassium. Correlation analysis (Pearson/Spearman), multivariate linear regression, and comparative analysis based on LTI classification (LTI2: low vs. high) were performed to evaluate the associations between LTI and nutritional parameters.</div></div><div><h3>Results</h3><div>Mean age was 70.2 ± 13.3 y; 64.9% were male. The mean LTI was 12.29 ± 3.32 kg/m². LTI showed strong positive correlation with weight (<em>r</em> = 0.85) and moderate associations with albumin (<em>r</em> = 0.50) and GNRI (<em>r</em> = 0.55). Multivariate analysis revealed weight (β = 0.144, <em>P</em> &lt; 0.001), serum albumin (β = 0.241, <em>P</em> = 0.001), prealbumin (β = 0.046, <em>P</em> = 0.015), and potassium (β = 0.800, <em>P</em> &lt; 0.001) levels as independent predictors of LTI. GNRI was inversely associated with LTI (β = −0.170, <em>P</em> &lt; 0.001). Patients in the high-LTI group had significantly higher weight, albumin, prealbumin, and GNRI (all <em>P</em> &lt; 0.05), but no significant differences in normalized protein catabolic rate, phosphate, or potassium.</div></div><div><h3>Conclusion</h3><div>LTI is strongly associated with conventional nutritional markers, particularly body weight and serum proteins. While GNRI correlates with LTI, it may reflect broader nutritional reserves rather than lean mass specifically. These findings underscore the importance of integrating body composition measurements into routine nutritional assessment in dialysis care.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"141 ","pages":"Article 112951"},"PeriodicalIF":3.0,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145308430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Negative outcomes occur early among geriatric patients with early signs of dysphagia in an acute care setting","authors":"Botilla Dalsgaard Jensen M.Sc. ,&nbsp;Sabina Mikkelsen M.Sc. ,&nbsp;Pernille Mølgaard Rosenvinge M.D. ,&nbsp;Robert Mariusz Modlinski M.D. ,&nbsp;Maria Dissing Olesen M.D. ,&nbsp;Simon Hosbond Poulsen M.D. ,&nbsp;Mette Holst Ph.D.","doi":"10.1016/j.nut.2025.112952","DOIUrl":"10.1016/j.nut.2025.112952","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to investigate the clinical outcomes associated with early signs of dysphagia (SD) in geriatric patients in an acute care setting.</div></div><div><h3>Methods</h3><div>In this prospective observational study with 18 mo follow-up, geriatric patients were screened for early signs of dysphagia in an acute care setting. Included patients were grouped based on swallowing function—SD or normal swallowing (NS). Follow-up data were retrieved from medical records on 332 patients with complete screening from baseline to 18 mo after admission.</div></div><div><h3>Results</h3><div>Among participants, 52.0% were male, median age was 79 (25th percentile 73.0; 75th percentile 85.0) y and median BMI was 26.1 (22.4;29.8) kg/m². Patients with early SD had higher mortality (41.3%) compared with NS (23.3%) (<em>P</em> &lt; 0.001). Both mortality and readmissions occurred within the first 90 d after screening compared with after 90 d. Using multiple hazard regression analyses, risk factors for mortality were identified as increasing age, SD, nutritional risk, low performance status, increasing number of comorbidities, and inflammation markers (<em>P</em> &lt; 0.05). Furthermore, low performance status, a high number of comorbidities, and low hemoglobin were risk factors for readmissions within the 18 mo follow-up period (<em>P</em> &lt; 0.05).</div></div><div><h3>Conclusions</h3><div>Early SD were associated with mortality after 18 mo, but readmissions were mostly pronounced within 90 d. Early dysphagia screening in older patients in general is relevant in the acute care setting as part of nursing care activities.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"141 ","pages":"Article 112952"},"PeriodicalIF":3.0,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preliminary effect of the postbiotic pA1c®HI in glucose metabolism of obese individuals: A pilot, randomized, double-blind, controlled nutritional intervention","authors":"Deyan Yavorov-Dayliev PhD ,&nbsp;Maria Isabel Pérez-Soto PhD ,&nbsp;Luis Gosálbez PhD ,&nbsp;Iñaki Iturria PhD ,&nbsp;Josune Ayo PhD","doi":"10.1016/j.nut.2025.112948","DOIUrl":"10.1016/j.nut.2025.112948","url":null,"abstract":"<div><h3>Aim</h3><div>The aim of this study was to assess the impact of pA1c®HI postbiotic administration on glucose metabolism, weight management, body composition, and metabolic health in obese individuals, both with and without prediabetes.</div></div><div><h3>Design</h3><div>A randomized, double-blind, placebo-controlled study was conducted with patients diagnosed with obesity. A total of 17 participants were administered either 1 capsule per day containing 1 × 10¹⁰ total cells of pA1c®HI or placebo for a duration of 12 weeks. Anthropometric measurements (body weight, body mass index, and fat mass), glucose metabolism indicators (HbA1c and glycemia), and insulin sensitivity markers (insulin and Homeostatic Model Assessment of Insulin Resistance [HOMA-IR]) were assessed before and after the intervention. Differences between groups were analyzed using the Student's t-test for independent samples for normally distributed variables, or the Mann-Whitney U-test for variables that did not follow a normal distribution.</div></div><div><h3>Results</h3><div>pA1c®HI consumption led to a glucose metabolism improvement, evidenced by reductions in HbA1c (–0.22 ± 0.07%; <em>P</em> = 0.018) compared with placebo. Although the difference between groups did not reach statistical significance, the intervention with pA1c®HI also led to improvements in other anthropometric measurements, including reductions in total weight, body mass index (BMI), fat mass, and visceral fat, alongside an increase in lean mass in comparison with placebo. Moreover, it was observed that supplementation with pA1c®HI reduced –8.8 ± 3.2 mm Hg (<em>P</em> = 0.029) the diastolic blood pressure compared to the placebo group. In a post-hoc analysis including the group of participants with prediabetes, pA1c®HI exhibited a trend toward reducing glycemia (11.8 ± 6.8%; 11.17 ± 6.4 mg/dL), HbA1c (0.17 ± 0.1%), HOMA-IR (60.2 ± 48.5%; 2.73 ± 2.2 points), and insulin levels (50 ± 42.1%; 9.74 ± 8.2 μU/mL) in comparison with placebo. Regarding lipid metabolism, while the differences observed between both groups were not statistically significant, clinically significant improvements in the postbiotic group were seen, highlighting decreases in total weight (1.55 ± 1.5 kg; <em>P</em> = 0.04), BMI (0.59 ± 0.5 points; <em>P</em> = 0.04), and fat mass (1.95 ± 1.3 kg; <em>P</em> = 0.016).</div></div><div><h3>Conclusion</h3><div>The findings from this study suggest that the postbiotic pA1c®HI holds promise as an effective intervention for managing glucose and lipid metabolism as well as improving body composition in patients with obesity.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"141 ","pages":"Article 112948"},"PeriodicalIF":3.0,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145200559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}