Nutrition最新文献

{"title":"Association between muscle mass assessed by an artificial intelligence–based ultrasound imaging system and quality of life in patients with cancer-related malnutrition","authors":"Daniel de Luis M.D. ,&nbsp;Angela Cebria M.D. ,&nbsp;David Primo M.D. ,&nbsp;Olatz Izaola M.D. ,&nbsp;Eduardo Jorge Godoy Ph.D. ,&nbsp;Juan Jose Lopez Gomez M.D.","doi":"10.1016/j.nut.2025.112763","DOIUrl":"10.1016/j.nut.2025.112763","url":null,"abstract":"<div><h3>Introduction</h3><div>Emerging evidence suggests that diminished skeletal muscle mass is associated with lower health-related quality of life (HRQOL) in individuals with cancer. There are no studies that we know of in the literature that use ultrasound system to evaluate muscle mass and its relationship with HRQOL.</div></div><div><h3>Objective</h3><div>The aim of our study was to evaluate the relationship between HRQOL determined by the EuroQol-5D tool and muscle mass determined by an artificial intelligence–based ultrasound system at the rectus femoris (RF) level in outpatients with cancer.</div></div><div><h3>Material and methods</h3><div>Anthropometric data by bioimpedance (BIA), muscle mass by ultrasound by an artificial intelligence–based at the RF level, biochemistry determination, dynamometry and HRQOL were measured.</div></div><div><h3>Results</h3><div>A total of 158 patients with cancer were included with a mean age of 70.6 ±9.8 years. The mean body mass index was 24.4 ± 4.1 kg/m² with a mean body weight of 63.9 ± 11.7 kg (38% females and 62% males). A total of 57 patients had a severe degree of malnutrition (36.1%). The distribution of the location of the tumors was 66 colon-rectum cancer (41.7%), 56 esophageal-stomach cancer (35.4%), 16 pancreatic cancer (10.1%), and 20.2% other locations. A positive correlation cross-sectional area (CSA), muscle thickness (MT), pennation angle, (BIA) parameters, and muscle strength was detected. Patients in the groups below the median for the visual scale and the EuroQol-5D index had lower CSA and MT, BIA, and muscle strength values. CSA (beta 4.25, 95% CI 2.03–6.47) remained in the multivariate model as dependent variable (visual scale) and muscle strength (beta 0.008, 95% CI 0.003–0.14) with EuroQol-5D index. Muscle strength and pennation angle by US were associated with better score in dimensions of mobility, self-care, and daily activities.</div></div><div><h3>Conclusion</h3><div>CSA, MT, and pennation angle of RF determined by an artificial intelligence–based muscle ultrasound system in outpatients with cancer were related to HRQOL determined by EuroQol-5D.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"135 ","pages":"Article 112763"},"PeriodicalIF":3.2,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143855002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are plant-based and omnivorous diets the same for muscle hypertrophy? A narrative review of possible challenges of plant-based diets in resistance-trained athletes","authors":"Damoon Ashtary-Larky","doi":"10.1016/j.nut.2025.112742","DOIUrl":"10.1016/j.nut.2025.112742","url":null,"abstract":"<div><div>This narrative review examines the potential challenges associated with plant-based diets in supporting muscle hypertrophy among resistance-trained athletes. Contrary to common assumptions, current evidence suggests that plant-based diets, when properly planned, can provide protein comparable to omnivorous diets. However, plant-based proteins are generally considered less anabolic due to lower digestibility, essential amino acid (EAA) content, and particularly lower leucine levels. The review discusses challenges and solutions for athletes aiming to maximize hypertrophy through plant-based diets, while highlighting the need for more robust research on advanced resistance-trained athletes.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"135 ","pages":"Article 112742"},"PeriodicalIF":3.2,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143806850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the association between human breast milk lipids and early adiposity rebound in children: a case-control study","authors":"Kento Sawane ,&nbsp;Ippei Takahashi ,&nbsp;Mami Ishikuro ,&nbsp;Hiroko Takumi ,&nbsp;Masatsugu Orui ,&nbsp;Aoi Noda ,&nbsp;Genki Shinoda ,&nbsp;Hisashi Ohseto ,&nbsp;Tomomi Onuma ,&nbsp;Fumihiko Ueno ,&nbsp;Keiko Murakami ,&nbsp;Naoko Higuchi ,&nbsp;Takashi Furuyashiki ,&nbsp;Tomohiro Nakamura ,&nbsp;Seizo Koshiba ,&nbsp;Kinuko Ohneda ,&nbsp;Kazuki Kumada ,&nbsp;Soichi Ogishima ,&nbsp;Atsushi Hozawa ,&nbsp;Junichi Sugawara ,&nbsp;Taku Obara","doi":"10.1016/j.nut.2025.112739","DOIUrl":"10.1016/j.nut.2025.112739","url":null,"abstract":"<div><h3>Objectives</h3><div>Adiposity rebound (AR) corresponds to the start of the second rise in the body mass index (BMI) curve during infant growth. Early AR (before age 5) confers increased risk of adiposity and metabolic disorders but is less likely to occur in breastfed infants. Although lipids in breast milk is important in child growth, information is limited regarding which lipids involve in AR. The object of this study was to explore breast milk lipids associated with the AR status in children.</div></div><div><h3>Methods</h3><div>We designed a case-control study of 184 mother–child pairs (AR cases: n = 93; controls: n = 91) included from the Tohoku Medical Megabank Project Birth and Three-Generation (TMM BirThree) Cohort Study. Breast milk was collected one month postpartum and comprehensive lipid analysis was performed. Partial least square-discriminant analysis (PLS-DA) was used to explore candidate lipids, and multivariable logistic regression analysis was used to evaluate associations with the AR status of children.</div></div><div><h3>Results</h3><div>We detected 667 lipid molecules in 12 lipid classes in breast milk. PLS-DA revealed an association of fatty acid-hydroxy fatty acid (FAHFA) and cholesterol ester (ChE) with AR status. Multivariable logistic regression analysis showed that, in pairs with exclusive breastfeeding at one month postpartum, FAHFA (OR 1.57 [95% CI, 1.06–2.32]) was positively associated with early AR, and ChE (OR 0.55 [95% CI, 0.36–0.86]) was negatively associated.</div></div><div><h3>Conclusions</h3><div>Breast milk lipids (FAHFA, ChE) associated with the AR status of children, indicating the potential to regulate child's adiposity and possible metabolic disorders in adulthood.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"135 ","pages":"Article 112739"},"PeriodicalIF":3.2,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143821025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex differences in fruit and vegetable consumption: Impact of menopausal transition on dietary choices","authors":"Anna Vittoria Mattioli FESC, FACC","doi":"10.1016/j.nut.2025.112741","DOIUrl":"10.1016/j.nut.2025.112741","url":null,"abstract":"","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"135 ","pages":"Article 112741"},"PeriodicalIF":3.2,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship of phase angle with postoperative pneumonia and survival prognosis in patients with esophageal cancer: A retrospective cohort study","authors":"Sanshiro Kawata M.D., Ph.D. ,&nbsp;Eisuke Booka M.D., Ph.D. ,&nbsp;Junko Honke ,&nbsp;Ryoma Haneda M.D., Ph.D. ,&nbsp;Wataru Soneda M.D. ,&nbsp;Tomohiro Murakami M.D., Ph.D. ,&nbsp;Tomohiro Matsumoto M.D., Ph.D. ,&nbsp;Yoshifumi Morita M.D., Ph.D. ,&nbsp;Hirotoshi Kikuchi M.D., Ph.D. ,&nbsp;Yoshihiro Hiramatsu M.D., Ph.D. ,&nbsp;Hiroya Takeuchi M.D., Ph.D","doi":"10.1016/j.nut.2025.112743","DOIUrl":"10.1016/j.nut.2025.112743","url":null,"abstract":"<div><h3>Objectives</h3><div>Phase angle (PhA), derived from bioelectrical impedance analysis (BIA), is an indicator of cell membrane health. Low PhA values reflect poor cellular function and low muscle mass. However, consensus regarding the appropriate cutoff value of PhA remains insufficient, and its impact on outcomes after esophagectomy in patients with esophageal malignancies is not well studied. We aimed to investigate whether preoperative PhA is associated with postoperative complication risk and survival prognosis and whether PhA decrease during the surgical preparation period is a prognostic factor in patients with esophageal cancer.</div></div><div><h3>Methods</h3><div>This retrospective cohort study analyzed data from 194 patients who had undergone esophagectomy for esophageal malignancies. A PhA measured several days before surgery, with cutoff values of 5.0° for men and 4.2° for women, was used. The relationship between postoperative pneumonia and clinicopathological factors and between low PhA and postoperative outcomes and survival prognosis was investigated. The preoperative PhA decline and survival prognosis were analyzed in 134 patients whose PhA was measured twice before surgery.</div></div><div><h3>Results</h3><div>Overall, 93 and 101 patients were classified into the low and high PhA groups, respectively. A multivariate analysis showed that a serum albumin level lower than 3.5 g/dL and low PhA were independent risk factors for pneumonia (odds ratio [OR] = 3.40, <em>P</em> = 0.03; OR = 3.42, <em>P</em> = 0.03, respectively). The low PhA group exhibited significantly higher intraoperative fluid balance (6.7 versus 6.0 mL/kg/h, <em>P</em> = 0.01) and a higher proportion of patients who failed to achieve early mobilization on the first postoperative day (46 versus 32%, <em>P</em> = 0.04) than did the high PhA group. Multivariate analysis using a Cox proportional hazards model revealed that low PhA was a poor survival prognostic factor, independent of the clinical stage of esophageal cancer (hazard ratio = 2.61, <em>P</em> &lt; 0.01). In patients whose PhA was measured twice preoperatively, a decrease in PhA during the preoperative period was a significant indicator of poor survival (hazard ratio = 2.59, <em>P</em> &lt; 0.01). The group with a decrease in PhA during the preoperative period had significantly fewer steps than the group with an increase in PhA (6220 ± 2880 versus 8200 ± 2850, <em>P</em> &lt; 0.01).</div></div><div><h3>Conclusions</h3><div>Low PhA was a risk factor for postoperative pneumonia in patients who had undergone esophagectomy and was associated with poor survival prognosis. A decrease in PhA during the preoperative period was a significant poor prognostic factor. Increasing physical activity before surgery may lead to an increase in PhA. Thus, it is important to measure and evaluate PhA changes sequentially in patients with esophageal cancer.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"135 ","pages":"Article 112743"},"PeriodicalIF":3.2,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143799659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating nutrition through the decades: Tailoring dietary strategies to women's life stages","authors":"Shilpa Sudhakar Harak M. Pharm., Ph.D. ,&nbsp;Smita Panditrao Shelke M. Pharm. ,&nbsp;Dhanshri Revannath Mali M. Pharm., Ph.D. ,&nbsp;Ayushi Atul Thakkar B. Pharm.","doi":"10.1016/j.nut.2025.112736","DOIUrl":"10.1016/j.nut.2025.112736","url":null,"abstract":"<div><div>The female-specific hormones are responsible for the different metabolic changes occurring in the overall well-being of a woman. Especially highlighted phases are the onset of puberty, menarche, pregnancy, lactation, and menopause. They involve significant metabolic changes, which alter the nutritional requirements. Women, in general, are often unaware of these varied nutritional requirements and fail to inculcate them in their diet, influencing their health. Increased calories, protein, iron, and calcium consumption during adolescence is required for bone growth and the prevention of osteoporosis later in life. The availability through a balanced diet of zinc and essential vitamins such as D, K, and B12 is also critical for a rapidly growing body. At present, infertility is also a pressing issue for couples. Female fertility can be enhanced by a diet high in plant-based protein, dietary fiber, omega-3 fatty acids, vitamins, and minerals. Foods rich in omega-3 fatty acids can help to enhance the quality of eggs, and plant-based proteins reduce the incidence of infertility. Thereafter, during pregnancy, nutritional requirements increase, especially for vitamins B6, B12, and D, calcium, proteins, folate, zinc, and iron. A properly balanced diet can satisfy basic nutritional requirements. However, iron supplements are essential for supporting the blood supply to the placenta and fetus. During menopause and menopausal transition, symptoms are observed like vaginal dryness, hot flashes, and irregular menstruation, followed by an increased threat of cardiovascular diseases, tumors, type 2 diabetes, and osteoporosis. Sufficient intake of protein, calcium, vitamins B, C, and D, and omega-3 fatty acids is important in managing the symptoms. The strategic combination of antioxidant-rich foods with a low-fat, plant-based diet can reduce the risk of cardiovascular disease and regulate body mass. The conclusion of this review is that timely changes in nutrition and strategizing dietary supplements can ease the transition phases of the female lifecycle and improve quality of life.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"135 ","pages":"Article 112736"},"PeriodicalIF":3.2,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143792491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between adiposity distribution and low-grade systemic inflammation: Tackling multicollinearity","authors":"Vanda Craveiro ,&nbsp;Milton Severo ,&nbsp;Elisabete Ramos","doi":"10.1016/j.nut.2025.112737","DOIUrl":"10.1016/j.nut.2025.112737","url":null,"abstract":"<div><h3>Objectives</h3><div>To examine the association between adiposity distribution and low-grade systemic inflammation, testing how the statistical approach can be used to tackle the multicollinearity between variables of adiposity.</div></div><div><h3>Methods</h3><div>Cross-sectional analysis of 987 adults (27 years old) from the EPITeen cohort (Porto, Portugal). Adiposity distribution was assessed based on the fat distribution of the participants, measured by whole-body dual-energy X-ray absorptiometry (DXA). Low-grade systemic inflammation was determined based on the serum high-sensitivity C-reactive protein (hsCRP) of the participants. The associations were estimated by linear regression models, stratified by sex, and multicollinearity between variables of adiposity was considered.</div></div><div><h3>Results</h3><div>The association (standardized β [95%CI]) between total body fat and hsCRP (ln) was 0.332 (0.252, 0.411) in women and 0.256 (0.175, 0.337) in men. Finally, in women, the association (standardized β [95%CI]) with hsCRP (ln) was −0.014 (−0.094, 0.065) for limb fat and 0.019 (−0.061, 0.099) for trunk fat, and, in men it was −0.136 (−0.216, −0.056) for limb fat and 0.130 (0.050, 0.211) for trunk fat.</div></div><div><h3>Conclusions</h3><div>After a comprehensive study of fat, its overall proinflammatory effect was acknowledged. Trunk fat was more proinflammatory than limb fat, even though the results were only statistically significant in men. Statistical analysis should consider multicollinearity between variables of adiposity, though simpler models could be used to address this problem.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"135 ","pages":"Article 112737"},"PeriodicalIF":3.2,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143783198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The critical care nutrition landscape in sub-Saharan Africa: Field insights and clinical commentary from resource-limited clinical settings","authors":"Fathima Abdoola MSc ,&nbsp;Harriet Gyamfuah Adu-Amoah MPhil ,&nbsp;Benedicta Kessewah Addo MSc ,&nbsp;Eric Komla Anku MPH ,&nbsp;Lauren Terese Hill PhD ,&nbsp;Bona Mwiinga Hamoonga MSc ,&nbsp;Kondwani Katundu PhD ,&nbsp;Dick Msiska BSc ,&nbsp;African Clinical Nutrition Consortium","doi":"10.1016/j.nut.2025.112740","DOIUrl":"10.1016/j.nut.2025.112740","url":null,"abstract":"<div><div>Critical care resources are very limited on the African continent. Within these limited resources, adequate and formalized critical care nutrition support is an even rarer clinical resource. While nutrition products for nasogastric feeding are specified in international consensus guidelines as essential requirements for critical care, these are desperately undersupplied in African Intensive Care Units (ICU). Malnutrition in ICUs in low and middle income countries is 65–78%, roughly double that of developed countries. Furthermore, malnutrition prevalence among severely ill oncology and infectious disease subgroups is 90–100% in the African setting. Dietetic resources in general are few and even fewer within critical care units. Integration of dietetic skills and services into ICU care is not routine, not governed by formalized protocols and is associated with low insight from non-nutrition health professionals. Overall level of perceived critical care nutrition skill and competency is lacking. These are barriers to ICU nutritional care along with poor compliance with clinical practice guidelines, delays in nutritional referrals, insufficient dietitian-to-patient ratios and severe shortage of medical nutrition products and feeding pumps. Both enteral and parenteral nutrition are subject to improvised formulation options because commercial product acquisition and procurement is not aligned to clinical need and is seldom reimbursed through government health systems. This results in both inadequate and inappropriate nutrition delivery as well as safety concerns. Combined clinical and political strategies for incremental quality enhancements and capacity building for critical care nutrition support are urgently needed in the region.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"134 ","pages":"Article 112740"},"PeriodicalIF":3.2,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143705841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduction of food insecurity over time: An unattainable reality for the poorest families?","authors":"Erica Costa Rodrigues Ph.D. ,&nbsp;Raquel de Deus Mendonça Ph.D. ,&nbsp;Priscila Pena Camargo M.D. ,&nbsp;Adriana Lúcia Meireles Ph.D.","doi":"10.1016/j.nut.2025.112738","DOIUrl":"10.1016/j.nut.2025.112738","url":null,"abstract":"<div><h3>Introduction</h3><div>Food insecurity (FI), associated with inadequate access to food, reflects social inequality. Shifts in sociodemographic factors significantly impact household FI. This study initially hypothesized that the progression of the COVID-19 pandemic would exacerbate socioeconomic challenges, thereby influencing the trends and responses related to FI within the studied population.</div></div><div><h3>Objective</h3><div>This study examines how social and demographic factors associated with FI change in an important population group during a health crisis, identifying vulnerable groups.</div></div><div><h3>Methods</h3><div>This longitudinal study analyzed a random sample of students from public schools in two Brazilian municipalities. Data were collected at 9-month intervals at four time points (T0, T1, T2, and T3) between 2020 and 2022. FI was measured using the Brazilian Food Insecurity Scale (BFIS) and analyzed as a discrete numerical variable (BFIS score -0 to 14 points). Comparisons across time points were analyzed using the paired Wilcoxon test. A generalized linear mixed model assessed the relationship between BFIS score and social and demographic variables over time.</div></div><div><h3>Results</h3><div>The average BFIS scores declined from 2.9 at T0 to 2.7 at T1; to 2.2 at T2 and T3, with significant differences between T0 and T2/T3 (<em>P</em> &lt; 0.001), and T1 and T2/T3 (<em>P</em> = 0.017). Higher BFIS scores were associated with families earning less than or equal to half the minimum wage Rate Ratio (RR) =4.93 [95% CI: 3.81–6.36], enrolled in social programs RR =1.14 [95% CI: 1.02–3.81], receiving emergency aid RR =1.15 [95% CI: 1.04–1.28] or food baskets RR=1.30 [95% CI: 1.18–1.43]. Families headed by Black/Brown individuals and women had higher BFIS scores, as did those headed by single individuals and those with low educational attainment.</div></div><div><h3>Conclusion</h3><div>There was no reduction in the average BFIS score for 2020 and 2022 for extremely poor families, despite improvements in other socioeconomic indicators. Families enrolled in social programs, beneficiaries of emergency aid, and households headed by women and black people experienced higher average BFIS scores, highlighting factors in the complex dynamics of FI during COVID-19 and a dynamically oscillating evolution in the sociodemographic landscape.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"135 ","pages":"Article 112738"},"PeriodicalIF":3.2,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143806849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The roles of vitamin C in infectious diseases: A comprehensive review","authors":"Runze Li ,&nbsp;Liangchao Guan ,&nbsp;Yue Liu ,&nbsp;Zongyi Hu ,&nbsp;Junyu Liu M.Sc. ,&nbsp;Cheng Li Ph.D. ,&nbsp;Hui Min Ph.D.","doi":"10.1016/j.nut.2025.112733","DOIUrl":"10.1016/j.nut.2025.112733","url":null,"abstract":"<div><div>Vitamin C is a versatile nutrient with essential antioxidant properties and roles in amino acid metabolism, collagen promotion, and hormone synthesis. It has long been regarded as benefitting infectious disease management, although its specific roles remain uncertain. The dominant view is that this efficacy not only stems from its redox regulation in the body but also from its profound impact on the immune system. This review provides a comprehensive overview of Vitamin C's effects on redox regulation and shows how the vitamin influences various immune cells and cell-intrinsic innate immunity signaling pathways, thereby updating and expanding our previous perspectives. Clinically, though some studies and case series have suggested potential benefits of Vitamin C in preventing and (or) treating respiratory tract infections and sepsis and septic shock, the evidence remains controversial. The current data is insufficient to support the routine clinical use of Vitamin C in managing these diseases and requires further rigorous evaluation to establish definitive efficacy and safety profiles. This review thoroughly examines current clinical research progress on Vitamin C, summarizes the primary controversies and their underlying causes, and proposes directions for future clinical research. Furthermore, preclinical evidence shows potential roles for Vitamin C in the supplementary treatment of the “Big Three” infectious diseases: acquired immunodeficiency syndrome (AIDS), tuberculosis, and malaria; however, systematic clinical studies in these areas are lacking. We examine related <em>in vitro</em> and animal studies, as well as clinical trials, and discuss potential roles for Vitamin C as a treatment and (or) adjuvant therapy.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"134 ","pages":"Article 112733"},"PeriodicalIF":3.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143706451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}