Nutrition最新文献

{"title":"Anthocyanin-rich dark-colored berries: A bibliometric analysis and review of natural ally in combating glucolipid metabolic disorders","authors":"Yujing He PhD,&nbsp;Xian Tang PhD,&nbsp;Ziheng Peng MSc,&nbsp;Xiaochao Bao MSc,&nbsp;Jie Wei PhD","doi":"10.1016/j.nut.2024.112669","DOIUrl":"10.1016/j.nut.2024.112669","url":null,"abstract":"<div><div>The risk of glycolipid metabolic disorders (GLMDs)–which encompass type 2 diabetes mellitus, hyperlipidemia, hypertension, obesity, non-alcoholic fatty liver disease, and atherosclerosis--is rising gradually and posing challenges to health care. With the popularity of healthy lifestyles, anthocyanin-rich berries have emerged as a potential dietary intervention. This review uses bibliometric analysis to synthesize current research on the role of anthocyanins in relieving GLMDs. Our examination of the literature underscores the diverse mechanisms by which anthocyanins exert their beneficial effects, including their intricate bioactivity and functional signaling pathways. The insights gleaned from anthocyanin research offer a promising avenue for harnessing the power of nature to support metabolic health and pave the way for integration into clinical strategies for GLMD management.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"131 ","pages":"Article 112669"},"PeriodicalIF":3.2,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142952421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between dietary diversity, eating behavior, and cognitive performance in economically disadvantaged school children","authors":"Chiu-Wen Yeh M.S. ,&nbsp;Meei-Shuyuan Lee Dr.P.H. ,&nbsp;Yuan-Ting C. Lo Ph.D. ,&nbsp;Yi-Chieh Chen M.S. ,&nbsp;Wei-Chih Chen B.S. ,&nbsp;Yi-Chen Huang Ph.D.","doi":"10.1016/j.nut.2024.112658","DOIUrl":"10.1016/j.nut.2024.112658","url":null,"abstract":"<div><h3>Objective</h3><div>The effect of dietary diversity and eating behavior on attention, and concentration among children lacking in resources is unclear. We aim to investigate the association between dietary diversity, eating behavior, and cognitive abilities among economically disadvantaged children at high risk of cognitive impairment.</div></div><div><h3>Methods</h3><div>This study enrolled 676 children aged 10–12 years from 16 free academic tutoring centers across Taiwan. Demographic and dietary behavior data were collected through self-administered questionnaires. Cognitive abilities, specifically attention and concentration, were assessed using the following validated tools: The Attention Test for Elementary School Children and the Concentration Questionnaire.</div></div><div><h3>Results</h3><div>Those who reported poor concentration and attention tend to have a higher prevalence of obesity. After adjustment for confounding variables by general linear model, a significant positive correlation was identified between dietary diversity score (DDS) and classroom concentration score (regression coefficient (β) = 0.24; <em>P</em> &lt; 0.0001). Conversely, the frequency of unhealthy food intake exhibited a negative correlation with concentration (β: −0.09; <em>P</em> = 0.025). Moreover, a negative correlation was observed between the frequency of instant food intake and the attention (β: −0.08; <em>P</em> = 0.04) and concentration scores (β: −0.09; <em>P</em> = 0.026).</div></div><div><h3>Conclusions</h3><div>Enhancing dietary diversity and reducing unfavorable food intake may improve cognitive performance in socioeconomically disadvantaged children.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"131 ","pages":"Article 112658"},"PeriodicalIF":3.2,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does vitamin D deficiency predispose to allergic proctocolitis?","authors":"Ozlem Akbulut M.D., Ph.D. ,&nbsp;Burcu Tahire Köksal M.D. ,&nbsp;Beril Aydın M.D., Ph.D. ,&nbsp;Tugce Oznacar M.D. ,&nbsp;Aysegül Haberal M.D. ,&nbsp;Figen Ozcay M.D.","doi":"10.1016/j.nut.2024.112659","DOIUrl":"10.1016/j.nut.2024.112659","url":null,"abstract":"<div><h3>Objectives</h3><div>Awareness of vitamin D (vit D) deficiency or insufficiency has increased alongside the rising prevalence of allergic diseases worldwide. We aimed to evaluate vit D levels in infants with allergic proctocolitis (AP) to explore a possible relationship between AP and vit D status.</div></div><div><h3>Methods</h3><div>This prospective, observational, case-control study was conducted between January 2020 and December 2023, including infants aged 6 months and younger diagnosed with AP (AP group) and healthy infants of the same age (control group). Vit D levels in AP patients at the time of diagnosis were compared with those of healthy infants.</div></div><div><h3>Results</h3><div>A total of 116 patients (72 AP, 44 control) were included in the study. Statistically significant differences were found in vit D levels, eosinophil count, and eosinophil percentage between the groups. Vit D was deficient or insufficient in 34.7% of AP patients. Vit D levels were significantly lower in infants with AP, and the risk of developing AP was 3.5 times higher in infants whose vit D levels were below 40.75 mcg/L.</div></div><div><h3>Conclusions</h3><div>Our finding that vit D levels are lower in infants with AP compared to healthy infants may support an association between AP and vit D deficiency. This could also provide insight into the increasing prevalence of AP linked to environmental factors. We recommend that vit D levels be assessed in infants with AP at the time of diagnosis.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"131 ","pages":"Article 112659"},"PeriodicalIF":3.2,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142910054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin K2 deficiency and its association with short stature in children: A cross-sectional study","authors":"Li-Li Chen MM ,&nbsp;Ke-Wen Xu MB ,&nbsp;Rui-Xue Cao MM ,&nbsp;Guang-Hui Shen MD ,&nbsp;Jin-Rong Liu MM ,&nbsp;Fan Zhou MP ,&nbsp;Zhe Li MM ,&nbsp;Ai-Jie Tang MP ,&nbsp;Pei-Ning Liu MM","doi":"10.1016/j.nut.2024.112660","DOIUrl":"10.1016/j.nut.2024.112660","url":null,"abstract":"<div><h3>Objectives</h3><div>This study examines the relationship between vitamin K2 (VK2) status and the occurrence of short stature in children.</div></div><div><h3>Methods</h3><div>A cross-sectional analysis was conducted between January 2021 and August 2022, involving 235 children with a clinical diagnosis of short stature at the Second Affiliated Hospital of Wenzhou Medical University (short stature group) and 454 children with average height (±1 SD) from the same period (healthy group). Serum VK2 levels were compared between the two groups. Multivariate logistic regression analysis was used to identify factors associated with short stature, and spearman correlation analysis was used to examine the relationship between VK2 status and age.</div></div><div><h3>Results</h3><div>Children in the short stature group exhibited lower VK2 levels (<em>P</em> = 0.019) and a significantly higher prevalence of VK2 deficiency (<em>P</em> = 0.011) compared to the healthy group. VK2 deficiency was identified as an independent risk factor for short stature (OR = 1.535, 95% CI = 1.061–2.222, <em>P</em> = 0.023) through multivariate logistic regression analysis. Furthermore, an inverse correlation was observed between serum VK2 levels and age in children aged 2 to 15 years (<em>ρ</em> = -0.133, <em>P</em> &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>VK2 deficiency may be associated with an increased risk of short stature in children.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"131 ","pages":"Article 112660"},"PeriodicalIF":3.2,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142910065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re. Mazza et al. “Portable bioimpedance analyzer for remote body composition monitoring: A clinical investigation under controlled conditions”","authors":"Emanuele Cereda M.D., Ph.D. ,&nbsp;Riccardo Caccialanza M.D. ,&nbsp;Analiza M. Silva Ph.D.","doi":"10.1016/j.nut.2024.112657","DOIUrl":"10.1016/j.nut.2024.112657","url":null,"abstract":"","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"131 ","pages":"Article 112657"},"PeriodicalIF":3.2,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sarc-Global: a new sarcopenia screening tool in older adults","authors":"Natalia Correia Lopes MS ,&nbsp;Ana Carolina Costa Vicedomini MS ,&nbsp;Natália Vieira Magalhães MS ,&nbsp;Dan Linetzky Waitzberg MD, PhD ,&nbsp;Wilson Jacob MD ,&nbsp;Alexandre Busse MD ,&nbsp;Douglas Ferdinando MS ,&nbsp;Rosa Maria Rodrigues Pereira MD ,&nbsp;Raquel Torrinhas MD ,&nbsp;Giliane Belarmino MD","doi":"10.1016/j.nut.2024.112654","DOIUrl":"10.1016/j.nut.2024.112654","url":null,"abstract":"<div><h3>Background</h3><div>Sarcopenia is associated with clinical complications that increase mortality in older adults. Current screening tools, such as Sarc-F and Sarc-CalF, focus primarily on muscular performance but have limited sensitivity in identifying elderly individuals at risk of sarcopenia. The present study aims to develop a more comprehensive sarcopenia risk screening tool, Sarc-Global, which integrates additional anthropometric and clinical variables to enhance the sensitivity and accuracy of sarcopenia risk assessment in older adults.</div></div><div><h3>Methods</h3><div>The aim of this cross-sectional study was to develop a sarcopenia risk screening tool, named Sarc-Global, with enhanced sensitivity, incorporating factors pertinent to the overall health of elderly individuals. Utilizing the criteria established by EWGSOP2 for diagnosing sarcopenia, we evaluated 395 community-dwelling elderly individuals. This evaluation served as a reference for assessing the efficacy of two validated questionnaires, Sarc-F and Sarc-CalF, and our newly developed Sarc-Global.</div></div><div><h3>Results</h3><div>Multiple logistic regression revealed that Sarc-Global integrates variables such as sex, age, medication use, body mass index, arm circumference, and handgrip strength, which are significantly associated with sarcopenia (<em>p</em>&lt;0.001). When combined with Sarc-CalF, these variables form the basis of the Sarc-Global model. In screening for sarcopenia risk, Sarc-Global demonstrated superior accuracy, specificity, and sensitivity (74%), outperforming Sarc-F (21%) and Sarc-CalF (34%).</div></div><div><h3>Conclusion</h3><div>Sarc-Global proves to be an effective tool for identifying elderly individuals at risk of sarcopenia.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"131 ","pages":"Article 112654"},"PeriodicalIF":3.2,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143141377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of feeding the medium-chain triacylglycerol on GLP-1 secretion in aged Brd4-heterozygous mice, which are a mouse model of aging","authors":"Musashi Kawamura M.S. ,&nbsp;Natsuyo Hariya Ph.D. ,&nbsp;Shiori Ishiyama Ph.D. ,&nbsp;Yuji Tanaka Ph.D. ,&nbsp;Keiko Ozato Ph.D. ,&nbsp;Kazuki Mochizuki Ph.D.","doi":"10.1016/j.nut.2024.112656","DOIUrl":"10.1016/j.nut.2024.112656","url":null,"abstract":"<div><h3>Objectives</h3><div>Gastrointestinal hormones, such as glucagon-like peptide 1 (GLP-1), gastric inhibitory polypeptide, and peptide YY (PYY) are important for reducing malnutrition at older ages because they are related to assimilation and feeding behavior. Medium-chain triacylglycerol (MCT) ameliorates metabolic symptoms and frailty in adults; however, whether it has the same effect in old age is unknown. To address this, we examined the changes in insulin and gastrointestinal hormones in aged <em>Brd4</em> (+/–) mice exhibiting symptoms of old age.</div></div><div><h3>Research Methods and Procedures</h3><div>Aged male wild-type and <em>Brd4</em> (+/–) mice were fed a long-chain triacylglycerol (LCT)- or MCT diet. Feeding, blood glucose, and plasma active GLP-1 protein concentrations were determined at 9 weeks using a meal tolerance test, and those gastrointestinal hormone genes were determined at 10 weeks.</div></div><div><h3>Results</h3><div>The liver and stomach weights and mRNA expression of <em>Gcg</em> (encodes GLP-1 protein) and <em>Pyy</em> in the colon were lower in LCT-fed <em>Brd4</em> (+/–) mice than those in LCT-fed wild-type mice; these were restored by the MCT diet. The blood concentration of active GLP-1 protein at 15 and 30 minutes postload was higher in MCT-fed <em>Brd4</em> (+/–) mice than that in those fed an LCT diet.</div></div><div><h3>Conclusions</h3><div>Aged <em>Brd4</em> (+/–) mice showed lower mRNA expression of <em>Gcg</em> and <em>Pyy</em> genes, and active GLP-1 protein secretion in the blood, which were as restored and enhanced with MCT feeding.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"131 ","pages":"Article 112656"},"PeriodicalIF":3.2,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Food protein–induced enterocolitis syndrome after involuntary gluten transgression in celiac children: A new increasingly common complication?","authors":"Carlos Trillo Belizón,&nbsp;Claudia García Barrionuevo,&nbsp;Adrián Muñoz-Cruzado Rosete,&nbsp;Alicia Ramos Rodríguez,&nbsp;Gema Lozano Sánchez,&nbsp;Jose Manuel Ramón Salguero","doi":"10.1016/j.nut.2024.112642","DOIUrl":"10.1016/j.nut.2024.112642","url":null,"abstract":"<div><div>Among the possible adverse reactions to gluten, celiac disease, non-celiac gluten sensitivity, and IgE-mediated wheat allergy have been classically described. A non–IgE-mediated reaction similar to food protein–induced enterocolitis syndrome (FPIES) after inadvertent gluten ingestion in a celiac patient was recently reported. We present three children affected by celiac disease with exquisite control, including appropriate adherence to an exclusion diet, who suffered a severe adverse food reaction after unappreciated outdoor ingestion of gluten, meeting the criteria for a definitive diagnosis of FPIES. The strict and prolonged exclusion of gluten from the diet is postulated as the possible trigger for this serious entity after an involuntary transgression. Although the first published cases are recent, we might be witnessing an increase in the frequency of presentation. Therefore, we believe emergency services must be alert to the possibility of diagnosis of FPIES in celiac patients due to involuntary transgressions. The determination of gluten glycoimmunopeptides in urine or stool samples may be useful for certifying the inadvertent consumption of wheat as the cause of FPIES.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"131 ","pages":"Article 112642"},"PeriodicalIF":3.2,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142910057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of ultra-processed foods on excess weight and dyslipidemia in schoolchildren","authors":"Cynthia Gonçalves Silva M.Sc. Human Nut. ,&nbsp;Claudia Saunders Ph.D. Public Health ,&nbsp;Luiz Felipe da Cruz Rangel Ph.D.Nut.Sci. (Researcher) ,&nbsp;Alessandra Alegre de Matos M.Sc. Human Nut. ,&nbsp;Francisco Martins Teixeira Ph.D. Immunology ,&nbsp;Beatriz Gonçalves Ribeiro Ph.D. Appl. Human Nut.","doi":"10.1016/j.nut.2024.112638","DOIUrl":"10.1016/j.nut.2024.112638","url":null,"abstract":"<div><h3>Objective</h3><div>To analyze the impact of the association between the consumption of ultra-processed foods (UPF), excess weight, and dyslipidemia in schoolchildren.</div></div><div><h3>Methods</h3><div>This is a cross-sectional study in which 420 schoolchildren aged 6 to 10 years from public schools in the municipality of Rio das Ostras, Brazil, were evaluated. Food consumption was assessed using the Previous Day Food Questionnaire (PDFQ-3), and physical activity (PA) was assessed using the Previous Day Physical Activity and Food Questionnaire (PDPAFQ). The following parameters were also evaluated: body weight, height, body mass index (BMI), waist circumference (WC), waist-to-height ratio (WHtR); serum concentrations of triglycerides (TG), total cholesterol (TC), LDL-cholesterol (LDL-c), HDL-cholesterol (HDL-c), and non-HDL-cholesterol. All foods and UPF groups were categorized according to the NOVA classification, and UPF consumption was expressed as a score and classified into tertiles. For statistical analysis, binary logistic regression models were tested and crude and adjusted Odds Ratios (OR) for PA were estimated with 95% confidence intervals (CI).</div></div><div><h3>Results</h3><div>Among the schoolchildren, 98.2% reported consuming UPFs the previous day. The schoolchildren in the “high consumption” tertile evidenced a higher intake of sugary beverages (SB), bread and savory crackers, and french fries. French fries consumption was higher among schoolchildren in the “high consumption” group compared to those in the lower tertiles (<em>p</em>&lt;0.001). The bread and savory crackers group and yogurt were more consumed by those in the “moderate and high consumption” tertiles compared to the “low consumption” tertile (<em>p</em>&lt;0.001). Schoolchildren in the high consumption tertile were more active (43.75% vs. 20.14%) (<em>p</em>&lt;0.001), while those in the low consumption tertile were less active (44.72% vs. 21.14%) (<em>p</em>&lt;0.001). A high prevalence of dyslipidemia (82.96%), excess weight (30.08%), abdominal obesity (AO) (18.3%), and no direct association between UPF consumption and excess weight and dyslipidemia were observed even after adjustment for PA (<em>p</em>&gt;0.05).</div></div><div><h3>Conclusions</h3><div>Despite the high prevalence of dyslipidemia, excess weight, and abdominal obesity observed, no direct association between UPF consumption and these conditions was identified. The practical implications of this study highlight the relevance of public policies and educational strategies aimed at promoting healthier eating habits and encouraging the practice of physical activities among school-age children.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"131 ","pages":"Article 112638"},"PeriodicalIF":3.2,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142910060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of adding heparin to parenteral nutrition on catheter intraluminal obstruction based on scanning electron microscopy in preterm neonates: A non-inferiority, randomized controlled trial","authors":"Jiao Li M.D. ,&nbsp;Jing Shi M.D. ,&nbsp;Jing Zhao M.D. ,&nbsp;Tingting Zhu M.D. ,&nbsp;Haiting Liu M.D. ,&nbsp;Xueshi Sun B.S. ,&nbsp;Linan Zeng Ph.D. ,&nbsp;Xiaoyan Yang M.D. ,&nbsp;Hongju Chen M.D. ,&nbsp;Junjie Ying Ph.D. ,&nbsp;Li Zhang M.D. ,&nbsp;Tao Xiong M.D. ,&nbsp;Jun Tang M.D. ,&nbsp;Dezhi Mu M.D.","doi":"10.1016/j.nut.2024.112655","DOIUrl":"10.1016/j.nut.2024.112655","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to assess the need for adding heparin to parenteral nutrition (PN) on reducing catheter intraluminal obstruction based on scanning electron microscopy (SEM) of peripherally inserted central catheter (PICC) in preterm neonates.</div></div><div><h3>Methods</h3><div>In this randomized controlled blinded non-inferiority trial, neonates with gestational age &lt;32 weeks requiring PICC to receive PN were enrolled and randomly divided into two groups. In the heparin group, 0.5 IU/mL heparin was added to PN for continuous infusion through PICC; while in the no-heparin group, there was no heparin added. All catheter tips were collected for SEM of catheter intraluminal obstruction. The primary outcome was the ratio of intraluminal obstructed area at catheter tip calculated by SEM. A non-inferiority margin of 0.1 was chosen. The duration of catheter patency, incidence of catheter-related complications, and heparin-related side effects were analyzed.</div></div><div><h3>Results</h3><div>Between June 1, 2021, and May 31, 2022, 91 neonates (gestational age of 28.17 ± 1.77 weeks) were ultimately enrolled. In the intention-to-treat analysis, the average ratio of intraluminal obstructed area at catheter tip indicated by SEM in no-heparin group was 0.313, and 0.362 in the heparin group (95% confidence intervals of the differences was –0.028 to 0.147). The lower bound of the one-side 95% confidence intervals was greater than –0.1, indicating non-inferiority. No statistically significant differences existed in the duration of catheter patency, the incidence of catheter-related complications between two groups.</div></div><div><h3>Conclusions</h3><div>PN without heparin was non-inferior to the addition of 0.5 IU/mL heparin to PN during infusion on reducing catheter intraluminal obstruction based on SEM of PICC in preterm neonates. These findings could reduce the unnecessary exposure to heparin in preterm neonates.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"131 ","pages":"Article 112655"},"PeriodicalIF":3.2,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}