Nutrition最新文献

{"title":"The effect of fruits and vegetables on children's mental and cognitive health: A systematic review of intervention studies and perspective for future research","authors":"Nicola A. Gillies PhD ,&nbsp;Amy L. Lovell PhD ,&nbsp;Karen E. Waldie PhD ,&nbsp;Clare R. Wall PhD","doi":"10.1016/j.nut.2024.112615","DOIUrl":"10.1016/j.nut.2024.112615","url":null,"abstract":"<div><h3>Objectives</h3><div>To synthesize evidence from fruit and vegetable intervention studies investigating mental or cognitive health outcomes (or both) in children ≤10 y. Our aim was to understand the efficacy of such interventions in improving measures of cognitive performance or mental health and to identify successful intervention elements to inform future research.</div></div><div><h3>Methods</h3><div>We conducted a systematic search of the Cochrane, Embase, PubMed, and CINAHL databases for articles published before August 2022 (PROSPERO registration no. CRD42022356571). A narrative synthesis was conducted according to the Synthesis Without Meta-Analysis guidelines.</div></div><div><h3>Results</h3><div>Of the 4686 articles identified, only 7 of the 17 full texts screened were included in the final review. No studies investigated the efficacy of interventions using “whole” fruits or vegetables. Six studies examined the effects of blueberries using drinks made from fresh (1 cup) or freeze-dried (30 g) blueberries and one study evaluated a mulberry powder–based drink. Sample sizes ranged from 14 to 54, and most studies were acute interventions with outcomes measured in a 2- to 3-h window (<em>n</em> = 6). Through a narrative synthesis of direction of responses, measures of executive function appeared sensitive to intervention effects in both acute and longer-term settings. Some concerns of risk of bias were evident, according to the RoB 2 tool, related to incomplete reporting of methodological aspects.</div></div><div><h3>Conclusions</h3><div>The studies identified through this systematic review could not directly address the planned research question, resulting in poor certainty of evidence. Future research with whole fruit and vegetable interventions could better inform population health strategies for improved mental and cognitive health outcomes in children.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"130 ","pages":"Article 112615"},"PeriodicalIF":3.2,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142722821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut microbiome and body composition with sorbitol intake during early lifespan","authors":"Ying-Yueh Chu Ph.D. ,&nbsp;Yu-Chen S.H. Yang Ph.D. ,&nbsp;Shih-Yuan Hsu MSc ,&nbsp;Hsien-Yu Fan Ph.D. ,&nbsp;Liang-Dar Hwang Ph.D. ,&nbsp;Jacus S. Nacis Ph.D. ,&nbsp;Yang Ching Chen Ph.D.","doi":"10.1016/j.nut.2024.112614","DOIUrl":"10.1016/j.nut.2024.112614","url":null,"abstract":"<div><h3>Objective</h3><div>The association of sorbitol intake with maintaining healthy body weight through the gut microbiome during early life was investigated.</div></div><div><h3>Research Methods and Procedures</h3><div>Sorbitol intake, body mass index (BMI), and fecal samples were collected in the total of 369 pregnant women with their infants (aged 4 months to 5 years) from the Taipei Mother-Infant Nutrition Cohort and 1946 children and adolescents (aged 6–18 years) from the Taiwan Puberty Longitudinal Study. The BMI-<em>z</em> score in sorbitol users was compared to that in sorbitol nonusers using generalized linear mixed model. The beta diversity of microbiome was investigated in both cohorts. The association between the richness of microbes and body composition was analyzed.</div></div><div><h3>Results</h3><div>The children and adolescents with high sorbitol intake had lower BMI-<em>z</em> score at 6 to 10 and 11 to 18 years of age (<em>P</em> &lt; 0.01) compared with those without sorbitol intake. The beta diversity of the microbiome differed significantly between the sorbitol users and nonusers. <em>Bifidobacterium</em> was higher in the gut of infants and children whose mothers were sorbitol users than that of infants and children whose mothers were sorbitol nonusers during pregnancy. Several microbes were involved in the regulation of obesity, such as <em>Staphylococcus, Faecalibacterium,</em> and <em>Oscillospiraceae_UCG-005</em> negatively associated with anthropometric measures.</div></div><div><h3>Conclusions</h3><div>Sorbitol intake was associated with lower child and adolescent BMI. Sorbitol consumption could shape the composition and richness of beneficial microbiota, contributing to the maintenance of ideal body weight and metabolic homeostasis in early life.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"130 ","pages":"Article 112614"},"PeriodicalIF":3.2,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142687595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revisiting the concepts of de novo lipogenesis to understand the conversion of carbohydrates into fats: Stop overvaluing and extrapolating the renowned phrase “fat burns in the flame of carbohydrate”","authors":"Heitor O. Santos Ph.D., R.D.N. ,&nbsp;Nilson Penha-Silva Ph.D.","doi":"10.1016/j.nut.2024.112617","DOIUrl":"10.1016/j.nut.2024.112617","url":null,"abstract":"<div><div>Carbohydrates can be converted into fatty acids via <em>de novo</em> lipogenesis (DNL). Although DNL is considered inefficient, these endogenous fatty acids contribute substantially to the esterification pathway in adipose tissue, together with fatty acids of feeding. This article revisited the concepts of DNL and aimed to discuss the clinical magnitude of carbohydrate overfeeding and fat mass accumulation. Although fat storage resulting from fat intake is more favorable for fat mass accrual than carbohydrates due to molecule structure and metabolism (e.g., oxidation and thermic effect), carbohydrates can substantially participate in lipogenesis and esterification under excess carbohydrate intake over time. Regarding only monosaccharide overfeeding, glucose and fructose favor the subcutaneous and visceral adipose tissue, respectively. While fructose and sucrose are considered villains in nonalcoholic fatty liver disease, energy surplus from carbohydrates, regardless of sources, can be considered an underlying cause of obesity. Interestingly, some degree of DNL in adipocytes may be favorable to mitigate a high deposition of fatty acids in the liver, conferring a physiological role. Although \"fat burns in the flame of carbohydrate\" is a praiseworthy phrase that has helped describe basic concepts in biochemistry for many decades, it appears to be overvalued and extrapolated even nowadays. DNL cannot be neglected. It is time to consider DNL an efficient biochemical process in health and disease.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"130 ","pages":"Article 112617"},"PeriodicalIF":3.2,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Two Techniques to Assess Muscle Mass Loss During ICU Stay: Muscle Ultrasound vs Bioelectrical Impedance Analysis","authors":"Gintarė Šostakaitė ,&nbsp;Martyna Jauniškytė ,&nbsp;Dominykas Budrys ,&nbsp;Kastytis Budrevičius ,&nbsp;Erika Šalčiūtė-Šimėnė ,&nbsp;Marija Svetikienė ,&nbsp;Tomas Jovaiša ,&nbsp;Tadas Žvirblis ,&nbsp;Andrius Klimašauskas ,&nbsp;Jūratė Šipylaitė","doi":"10.1016/j.nut.2024.112607","DOIUrl":"10.1016/j.nut.2024.112607","url":null,"abstract":"<div><h3>Background and aims</h3><div>Muscle wasting is a prevalent issue among long-term critically ill patients and is associated with adverse clinical outcomes. Evaluating muscle mass in the ICU presents challenges due to the lack of a consistent methodology and the significant impact of fluid balance range in ICU patients. This prospective study aimed to compare the utility of bioelectrical impedance analysis (BIA) and ultrasound (US) for monitoring muscle wasting in critically ill patients over an initial seven-day period of critical illness.</div></div><div><h3>Methods</h3><div>Conducted in a tertiary teaching hospital's mixed ICU, the study included adult patients with ICU stays exceeding seven days. Measurements were taken on Day 1 (within 24 hours of ICU admission), Day 5, and Day 7.</div></div><div><h3>Results</h3><div>Out of 101 enrolled patients, 74 were male, with a mean age of 55.3 (SD 14.8) years. The mean APACHE II score was 18.2 (SD 7.2), and the Day 1 SOFA score was 7.9 (SD 3.2). The ICU survival rate was 65%, and the mean ICU length of stay was 19.2 (SD 19.2) days. Statistically significant muscle mass loss was detected by US measurement, demonstrating the relative change in general muscle thickness: -2.5% (SD 11.8) by Day 5 and -6.5% (SD 12.4) by Day 7 (<em>P</em> &lt; 0.001). BIA demonstrated no significant change in phase angle, as the relative change by Day 5 was -3.3% (SD 19.9) and by Day 7 it was -1.9% (SD 21.9), with no significant difference (<em>P</em> = 0.374).</div></div><div><h3>Conclusions</h3><div>Ultrasound was a more suitable method for assessing and monitoring muscle wasting during ICU stays, while bioelectrical impedance analysis failed to demonstrate a comparable degree of muscle loss at Days 5 and 7. This study highlights the importance of selecting an appropriate assessment method based on the specific clinical context, emphasizing the reliability of US in evaluating muscle wasting among critically ill patients.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"130 ","pages":"Article 112607"},"PeriodicalIF":3.2,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142643939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripheral fatty acids and outcome of assisted reproduction","authors":"Valentina De Cosmi ,&nbsp;Sonia Cipriani ,&nbsp;Marie-Louise Syren ,&nbsp;Stefano Turolo ,&nbsp;Fabio Parazzini ,&nbsp;Marco Reschini ,&nbsp;Martina Abodi ,&nbsp;Walter Vegetti ,&nbsp;Francesca Chiaffarino ,&nbsp;Camilla Bertoni ,&nbsp;Edgardo Somigliana ,&nbsp;Carlo Agostoni","doi":"10.1016/j.nut.2024.112616","DOIUrl":"10.1016/j.nut.2024.112616","url":null,"abstract":"<div><h3>Objectives</h3><div>The present study investigated the relationship between fatty acid levels in whole blood in women undergoing in vitro fertilization and four successive assisted reproductive technology (ART) outcomes.</div></div><div><h3>Methods</h3><div>A cross-sectional study was performed on data from a prospective cohort study conducted between 2014 and 2016.</div></div><div><h3>Results</h3><div>Participants were 238 women undergoing in vitro fertilization and participating in a study on the role of lifestyle habits and diet in ART outcomes. Blood polyunsaturated fatty acids were measured by gas chromatography. Overall, higher blood levels of monounsaturated fatty acids and oleic acid and higher ω-6/ω-3 ratio and arachidonic/docosahexaenoic acid ratio were associated with more favorable ART outcomes. By contrast, higher concentrations of long chain polyunsaturated fatty acids tended to be negatively associated with the considered outcomes.</div></div><div><h3>Conclusions</h3><div>Further prospective studies are needed to determine the ranges of fatty acid concentrations that are optimal for women with subfertility.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"130 ","pages":"Article 112616"},"PeriodicalIF":3.2,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142705284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the adherence to perioperative nutritional care protocols in Brazilian hospitals: The PreopWeek study","authors":"Maria Cristina Gonzalez M.D., Ph.D. ,&nbsp;Thiago J.M. Gonçalves M.D., Ph.D. ,&nbsp;Valéria A. Rosenfeld M.D. ,&nbsp;Silvana P. Orlandi R.D., Ph.D. ,&nbsp;Pedro E. Portari-Filho M.D., Ph.D. ,&nbsp;Antonio Carlos L. Campos M.D., Ph.D.","doi":"10.1016/j.nut.2024.112611","DOIUrl":"10.1016/j.nut.2024.112611","url":null,"abstract":"<div><h3>Objectives</h3><div>The study (PreopWeek) aimed to assess the perioperative nutritional care for major surgical patients in Brazilian hospitals, focusing on adherence to emerging multimodal protocols like Enhanced Recovery After Surgery and Acceleration of Total Postoperative Recovery.</div></div><div><h3>Methods</h3><div>An observational cross-sectional study was conducted in Brazilian hospitals enrolled voluntarily from June 19 to June 23, 2023 (convenience sample). Data were collected through patient interviews and medical records review.</div></div><div><h3>Results</h3><div>Data from 219 patients up to the fifth postoperative day or postoperative discharge across 24 hospitals were analyzed. Only three hospitals (12.5%) had established institutional perioperative protocols. Most of the patients were female (60.3%) and over 60 y old (81.7%) and underwent gastrointestinal (34.7%) or orthopedic (33.3%) surgeries. General and nutritional preoperative counseling was provided to a respective 82.2% and 62.6% of the patients. Only 25.7% of the patients had preoperative fasting for up to 3 h, and 28.8% received carbohydrate-rich supplements. Immunonutrition was not received by 43.8% at any point. Although most started postoperative refeeding within 24 h (81.7%), 39.4% started with a liquid diet and 70.6% reported postoperative immobilization in the first 24 h. Notable differences were observed between hospitals with and without protocols. Hospitals with institutional protocols reported significantly more preoperative exercises and nutritional counseling and higher adherence rates for all the perioperative protocols.</div></div><div><h3>Conclusions</h3><div>Our study demonstrates a lack of adherence to the multimodal protocols, even in hospitals with institutional protocols. Future educational programs are necessary to improve this result.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"130 ","pages":"Article 112611"},"PeriodicalIF":3.2,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142644617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plant-derived compounds as potential neuroprotective agents in Parkinson's disease","authors":"Chengu Niu M.D. ,&nbsp;Yu Zou M.Sc. ,&nbsp;Miaoxian Dong M.B.B.S. ,&nbsp;Yingcai Niu Ph.D.","doi":"10.1016/j.nut.2024.112610","DOIUrl":"10.1016/j.nut.2024.112610","url":null,"abstract":"<div><h3>Objectives</h3><div>Current Parkinson's disease (PD) medications treat symptoms; none can slow down or arrest the disease progression. Disease-modifying therapies for PD remain an urgent unmet clinical need. This review was designed to summarize recent findings regarding to the efficacy of phytochemicals in the treatment of PD and their underlying mechanisms.</div></div><div><h3>Methods</h3><div>A literature search was performed using PubMed databases from inception until January 2024.</div></div><div><h3>Results</h3><div>We first review the role of oxidative stress in PD and phytochemical-based antioxidant therapy. We then summarize recent work on neuroinflammation in the pathogenesis of PD, as well as preclinical data supporting anti-inflammatory efficacy in treating or preventing the disease. We last evaluate evidence for brain mitochondrial dysfunction in PD, together with the phytochemicals that protect mitochondrial function in preclinical model of PD. Furthermore, we discussed possible reasons for failures of preclinical-to-clinical translation for neuroprotective therapeutics.</div></div><div><h3>Conclusions</h3><div>There is now extensive evidence from preclinical studies that neuroprotective phytochemicals as promising candidate drugs for PD are needed to translate from the laboratory to the clinic.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"130 ","pages":"Article 112610"},"PeriodicalIF":3.2,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142639455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between improved dysphagia and increased trunk muscle mass in older patients with stroke undergoing convalescent rehabilitation","authors":"Ryo Shiraishi R.P.T., Ph.D. ,&nbsp;Setsuko Kato R.N. ,&nbsp;Nami Shiraishi R.D. ,&nbsp;Takahiro Ogawa M.D., Ph.D.","doi":"10.1016/j.nut.2024.112609","DOIUrl":"10.1016/j.nut.2024.112609","url":null,"abstract":"<div><h3>Objective</h3><div>The association between dysphagia and activities of daily living in patients with stroke has been reported, but the effect of improved dysphagia on the increase in trunk muscle mass is not clear. The aim of this study was to investigate the relationship between improved dysphagia and increased trunk muscle mass in older patients with stroke.</div></div><div><h3>Research Methods &amp; Procedures</h3><div>This retrospective, case-control study enrolled patients with stroke aged ≥65 years. Dysphagia was evaluated using the Kuchi-Kara Taberu (KT) Index. Patients were classified into two groups according to KT Index at discharge: improved dysphagia group (≥57 scores) and non-improved dysphagia group (&lt;57 scores). The primary outcome of the study was Trunk Muscle Mass Index (TMI) gain from admission to discharge. Multiple regression analysis was performed to investigate the association between trunk muscle mass gain and improved dysphagia.</div></div><div><h3>Results</h3><div>There were 153 participants with a mean age of 79.8 ± 7.7 years, and 89 (58%) were classified in the improved dysphagia group. The TMI gain was greater in the improved dysphagia group compared to that in the nonimproved group. Multiple regression analysis showed that improved dysphagia (β: 0.776, 95% confidence interval: 0.643 to 0.909, <em>P</em> &lt; 0.001) was independently associated with TMI gain.</div></div><div><h3>Conclusion</h3><div>Improved dysphagia was independently associated with trunk muscle mass gain, suggesting that improved dysphagia is important for trunk muscle mass gain in patients with stroke.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"130 ","pages":"Article 112609"},"PeriodicalIF":3.2,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142643991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preventing Progression of Renal Disease: A New Method for Monitoring Body Fat Percentage in Predialysis Chronic Kidney Disease Patients","authors":"María del Rocío Jiménez-Mérida R.N., M.Sc., Ph.D. ,&nbsp;José Manuel Alcaide-Leyva R.N., M.Sc., Ph.D. ,&nbsp;Miguel Lopez-Lucena R.N. ,&nbsp;Silvia Portero de la Cruz R.N., M.Sc., Ph.D. ,&nbsp;Rafael Molina-Luque R.N., M.Sc., Ph.D. ,&nbsp;Pablo Martínez-Angulo R.N., M.Sc., Ph.D.","doi":"10.1016/j.nut.2024.112605","DOIUrl":"10.1016/j.nut.2024.112605","url":null,"abstract":"<div><h3>Background and Aims</h3><div>Chronic kidney disease (CKD) is a progressive condition affecting metabolic pathways and physiological mechanisms. In Spain, CKD prevalence has risen, increasing patients requiring renal replacement therapy (RRT). Managing nutritional status in advanced CKD (ACKD) patients is crucial as it influences disease progression and quality of life. This study aims to describe the nutritional status of predialysis patients at University Hospital Reina Sofia, Cordoba, Spain, and develop a quick and easy model for estimating body fat percentage without bioimpedance.</div></div><div><h3>Methods and Results</h3><div>This cross-sectional study, conducted from February to May 2023, involved 106 patients from the ACKD consultation at the University Hospital Reina Sofia. Inclusion criteria were stage 3 or 4 CKD patients who consented to participate. Data included demographic and anthropometric variables, with body composition assessed using a Tanita BC-545N bioimpedance analyzer.</div><div>The sample included 32 females (30.5%) and 73 males (69.5%), with an average BMI of 30.31 (SD 5.48). Significant findings were higher body fat percentage in women (37.82%) than men (27.86%; <em>P</em> &lt; 0.001) and notable differences in waist circumference and waist-to-hip ratio between sexes. Multiple linear regression showed waist circumference, height, and sex as significant predictors of body fat percentage, with an intraclass correlation coefficient of 0.71 (95% CI = 0.59–0.79).</div></div><div><h3>Conclusion</h3><div>Accurately assessing body composition in CKD patients is crucial as traditional measures like BMI may not capture health risks effectively. The developed model offers a practical alternative to bioimpedance for estimating body fat percentage, potentially improving CKD management and patient outcomes. Further validation in diverse populations and integration with lifestyle interventions is needed.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"130 ","pages":"Article 112605"},"PeriodicalIF":3.2,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142643952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lactiplantibacillus plantarum TCCC11824 exerts hypolipidemic and anti-obesity effects through regulation of NF-κB-HMGCR pathway and gut microbiota in mice and clinical patients","authors":"Xiaomin Feng ,&nbsp;Haijie Hu ,&nbsp;Feiliang Zhong ,&nbsp;Ying Hou ,&nbsp;Xiujuan Li ,&nbsp;Qi Qin ,&nbsp;Yang Yang ,&nbsp;Xuegang Luo","doi":"10.1016/j.nut.2024.112598","DOIUrl":"10.1016/j.nut.2024.112598","url":null,"abstract":"<div><div>A strong association exists between the high-fat diet (HFD) and the incidence of obesity, hyperlipidemia and cardiovascular disease, affecting an increasing number of individuals. More and more research has shown that probiotics and gut microbiota play important roles in dietary absorption, metabolism, and general health of the host. This aim of this study was to evaluate the therapeutic effects and the underlying mechanisms of <em>Lactiplantibacillus plantarum</em> TCCC11824 (CGMCC 8198) on hyperlipidemia and obesity in mice and humans. First, there was a dose-dependent improvement in HFD-induced hyperlipidemia and obesity in mice that had been treated with <em>L. plantarum</em> TCCC11824 for 5 wk, thus restoring the balance of the gut microbiota. Furthermore, it showed that cell lysate of <em>L. plantarum</em> TCCC11824 could directly exhibit protective effects on the hepatocyte steatosis induced by oleic acid, and regulate the expression of HMGCR by inhibiting the NF-κB pathway. Importantly, <em>L.plantarum</em> TCCC11824 ameliorated the expression of indicators of hyperlipidemia and inhibited the synthesis of SCFAs (short-chain fatty acids), as shown by blood and fecal tests in hyperlipidemic patients. In summary, <em>L. plantarum</em> TCCC11824 exerts anti-hyperlipidemic and anti-obesity effects through the regulation of HMGCR via NF-κB and modulating gut microbiota, indicating its potential as a dietary supplement for the treatment of hyperlipidemia and obesity.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"130 ","pages":"Article 112598"},"PeriodicalIF":3.2,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142748270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}