Nutrition最新文献

{"title":"β-hydroxybutyrate attenuates diabetic renal and muscular pathologies in a streptozotocin-induced diabetic model","authors":"Rahmawati Aisyah Ph.D. ,&nbsp;Shohei Katsuya M.Sc. ,&nbsp;Kenshu Miyata M.Sc. ,&nbsp;Zhenhgyu Chen M.Sc. ,&nbsp;Mayu Horii M.Sc. ,&nbsp;Ayane Kudo M.Sc. ,&nbsp;Thanutchaporn Kumrungsee Ph.D. ,&nbsp;Jun Tsubota Ph.D. ,&nbsp;Noriyuki Yanaka Ph.D.","doi":"10.1016/j.nut.2025.112792","DOIUrl":"10.1016/j.nut.2025.112792","url":null,"abstract":"<div><div>Diabetes and its associated complications are the leading cause of mortality worldwide. Strategies have been rapidly developed to reduce diabetic complications and the overall quality of life of patients with diabetes. β-hydroxybutyrate (BHB), the most abundant ketone body generated from fatty acids in the liver, provides energy sources under nutrient deprivation and has various potential health benefits as a functional food. However, its role in diabetic pathologies is unclear. In this study, we examined the effect of BHB on the kidney and muscle functions in streptozotocin (STZ)-induced diabetic mice. BHB supplementation exerted anti-inflammatory effects on the kidneys and improved renal tubule injury and fibrosis in STZ-induced mice. Furthermore, BHB alleviated diabetes-induced muscle atrophy, indicated by the increased fiber area and normalized fiber area distribution in BHB-supplemented STZ-treated mice. Our study demonstrates the beneficial effects of BHB in improving diabetic complications, particularly diabetic nephropathy and myopathy, and highlights the potential of BHB as a functional food for the treatment of diabetes.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"137 ","pages":"Article 112792"},"PeriodicalIF":3.2,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143943180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impedance-derived phase angle as an indicator of physical function in maintenance hemodialysis patients","authors":"Xin Li M.D. ,&nbsp;Kun Zhang M.Sc. ,&nbsp;Qi Guo M.D., Ph.D. ,&nbsp;Wei Ding M.D., Ph.D. ,&nbsp;Jianying Niu M.D., Ph.D. ,&nbsp;Junli Zhao M.D., Ph.D. ,&nbsp;Liming Zhang M.Sc. ,&nbsp;Hualin Qi M.D., Ph.D. ,&nbsp;Suhua Zhang M.D., Ph.D. ,&nbsp;Chen Yu M.D., Ph.D.","doi":"10.1016/j.nut.2025.112795","DOIUrl":"10.1016/j.nut.2025.112795","url":null,"abstract":"<div><h3>Objectives</h3><div>Maintenance hemodialysis (MHD) patients often impairs physical function, leading to reduced quality of life and increased mortality. Phase angle (PhA), derived by bioelectrical impedance analysis, has been proposed as a predictor of sarcopenia, holds promise as a potential indicator of physical function. The aim of this study was to identify the association between PhA and physical function in MHD patients.</div></div><div><h3>Methods</h3><div>This was a multicenter, cross-sectional study included MHD patients from seven dialysis centers from 2020 to 2021. Physical function was measured by handgrip strength (HGS), Short Physical Performance Battery (SPPB), 4-meter gait speed, and timed up and go test (TUGT). Nutritional status was assessed by malnutrition inflammation score (MIS). Body composition, including PhA at 50kHz, was measured by bioelectrical impedance analysis. Sarcopenia was diagnosed according to the 2019 update version of the Asian Working Group for Sarcopenia. Multivariable linear regression models were performed to determine the association between PhA and physical function.</div></div><div><h3>Results</h3><div>A total of 864 patients (61% male, median age 63 years) were analyzed. The median PhA was 4.5 (interquartile range: 3.9–5.2)°. PhA was negatively associated with age, MIS, Charlson comorbidity index, extracellular water/total body water, visceral fat area, and TUGT, and positively associated with hemoglobin, serum albumin, body mass index, height, weight, skeletal muscle mass index (SMI), SPPB, 4-meter gait speed, and HGS. These associations were consistent across PhA values of whole body and five body segments—right arm, left arm, trunk, right leg, and left leg. Multivariable linear regression analyses indicated that PhA was independently associated with higher SPPB scores (<em>β</em> = 0.33, <em>P</em> &lt; 0.001), faster gait speed (<em>β</em> = 0.29, <em>P</em> &lt; 0.001), greater HGS (<em>β</em> = 0.28, <em>P</em> &lt; 0.001) and shorter TUGT time (<em>β</em> = –0.20, <em>P</em> &lt; 0.001) after fully adjusted for age, sex, spKt/V, dialysis vintage, Charlson comorbidity index, MIS and skeletal muscle index. Subgroup analyses confirmed the robust association of PhA with physical function across different patient characteristics including sarcopenia, malnutrition, age, sex, and diabetes.</div></div><div><h3>Conclusions</h3><div>Higher PhA was independently associated with better physical function in MHD patients. Our study suggested that PhA may serve as a non-invasive, reliable clinical indicator for assessing functional status in this population.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"136 ","pages":"Article 112795"},"PeriodicalIF":3.2,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143943047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance of AI muscle segmentation models: How good is good enough?","authors":"Alain R. Viddeleer M.D., Ph.D.,&nbsp;Issi R. Vedder M.D.,&nbsp;Reinoud P.H. Bokkers M.D., Ph.D.","doi":"10.1016/j.nut.2025.112793","DOIUrl":"10.1016/j.nut.2025.112793","url":null,"abstract":"","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"136 ","pages":"Article 112793"},"PeriodicalIF":3.2,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional supplementation in pregnant, lactating women and young children following a plant-based diet: A narrative review of the evidence","authors":"María Pilar Herrero Jiménez MSc ,&nbsp;Susana del Pozo de la Calle PhD ,&nbsp;Carmen Cuadrado Vives PhD ,&nbsp;Daniel Escobar Sáez MSc","doi":"10.1016/j.nut.2025.112778","DOIUrl":"10.1016/j.nut.2025.112778","url":null,"abstract":"<div><div>Plant-based diets are increasingly popular in contemporary society. While they are suitable for all life stages, there is a potential risk of nutrient deficiencies, particularly in omega-3 fatty acids, vitamins A, D, and B₁₂, zinc, iodine, selenium, choline, and creatine. During pregnancy and lactation, the nutritional demands increase significantly, making proper supplementation essential. Breastfeeding remains the optimal feeding method for infants, provided key nutrient needs are met through supplementation. A bibliographic search in Scopus, Web of Science, and PubMed focused on plant-based diets, supplementation, and key nutrients over the past 10 years. Studies involving diseases or duplicates were excluded, and data were analyzed from European and U.S. sources to assess nutrient supplementation trends. Micronutrient deficiencies during pregnancy and lactation can negatively impact infant neurological development. Vitamin A supports vision and immunity, while vitamin D aids fetal bone mineralization. Deficiency in vitamin B₁₂ can lead to anemia and neurological issues. Zinc, iodine, selenium, omega-3 fatty acids (EPA and DHA), choline, and creatine also play critical roles in development and may require supplementation in plant-based diets. With careful planning, plant-based diets can meet nutritional needs during pregnancy, lactation, and childhood. Supplementation with key micronutrients, including choline and creatine, is essential for neurodevelopment and energy metabolism. Dietitians play a vital role in guiding individualized dietary plans, and further research is needed on optimal supplement dosages and long-term health effects.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"136 ","pages":"Article 112778"},"PeriodicalIF":3.2,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143948556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low variability of resting metabolic rate among early, middle, and late achievers of steady state suggests a shortened indirect calorimetry protocol for young children","authors":"Adeline Pretorius Ph.D. ,&nbsp;Paola S. Wood Ph.D. ,&nbsp;Piet J. Becker Ph.D. ,&nbsp;Friedeburg A.M. Wenhold Ph.D.","doi":"10.1016/j.nut.2025.112779","DOIUrl":"10.1016/j.nut.2025.112779","url":null,"abstract":"<div><h3>Objective</h3><div>Standardized protocols for measuring resting metabolic rate (RMR; kJ/d) in children, using indirect calorimetry (IC), are lacking. In this cross-sectional, observational study we aimed to determine, in a diverse group of children, variability of RMR-associated measurements after achieving steady state (SS) with a shortened IC protocol. RMR of 120 conveniently sampled healthy Southern African children 6 to 9 years (60 black [32 girls], 60 white [37 girls]) was measured via IC (Quark RMR, Cosmed).</div></div><div><h3>Methods</h3><div>Measurements, without a prior rest period, continued for 15 to 20 minutes. Participants were categorized according to time when machine-generated SS was achieved: early achievers &lt;5 minutes, middle achievers ≥5 and &lt;10 minutes, late achievers ≥10 minutes. Readings before achieving SS were eliminated. Intra-individual percentage coefficient of variation of the mean RMR (kJ/d), VCO₂ (mL/min), VO₂ (mL/min), and respiratory quotient (VCO₂/VO₂) was determined for each SS category for the remaining measurement period.</div></div><div><h3>Results</h3><div>For 113 (94%) participants, usable data were obtained. Mean (min; max) time to reach SS was 5.7 minutes (0.0; 16.2). Nineteen (17%; 6 black; 10 girls [3 black]) did not achieve SS, with no significant difference between sexes (<em>P</em> = 0.290). Significantly (<em>P</em> = 0.048) more white (12%) than black (5%) participants did not achieve SS. Forty-seven (50%) were early, 29 (31%) middle, and 18 (19%) late achievers of SS. There was no significant difference in the sample distribution of SS categories between sexes (<em>P</em> = 0.955) and race/ethnicity categories (<em>P</em> = 9.758).</div></div><div><h3>Conclusions</h3><div>After achieving SS, percentage coefficient of variation for all RMR-related variables remained ≤2.89%, well below the recommended &lt;5% to 10% for adults. A shortened IC protocol can be considered for diverse groups of 6- to 9-year-old children.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"136 ","pages":"Article 112779"},"PeriodicalIF":3.2,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143899182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of protein consumption and supplementation on body composition and functional capacity in cardiovascular disease patients undergoing cardiovascular rehabilitation: A systematic review and meta-analysis","authors":"Caroline de Souza Pellegrini ,&nbsp;Linda Louise Castelo Branco Lima ,&nbsp;Thais Crislayne Rodrigues ,&nbsp;Luciana de Abreu Silva ,&nbsp;Gabriela Lima de Melo Ghisi ,&nbsp;Silvia Fernandes Maurício ,&nbsp;Camila Kümmel Duarte","doi":"10.1016/j.nut.2025.112773","DOIUrl":"10.1016/j.nut.2025.112773","url":null,"abstract":"<div><div>Cardiovascular diseases (CVD) remain the leading cause of death worldwide. Nutritional strategies, including protein intake, play a crucial role in cardiovascular rehabilitation by supporting overall health and recovery. This review explores the hypothesis that protein supplementation enhances muscle mass, leading to improved body composition and functional capacity in CVD patients. We conducted a systematic review of randomized controlled trials (RCTs) in accordance with the Cochrane Manual for Systematic Reviews of Interventions, with the protocol registered under CRD42022292687. A comprehensive search strategy, incorporating population, intervention, and study design terms, was executed across PubMed, EMBASE, Scopus, and Web of Science from data inception to February 1, 2024. Study quality was assessed using the Cochrane risk of bias tool (RoB 2.0), and meta-analysis was performed with statistical packages in Rstudio 3.6.2. From 10 939 initial citations, seven RCTs and three pilot RCTs met the eligibility criteria. Sample sizes ranged from 11 to 70 participants, with mean ages between 55 and 80 years. The narrative synthesis revealed mixed effects of protein supplementation on body composition and functional capacity. Lean body mass improvements were observed in several trials, particularly when protein intake was combined with resistance training. However, reductions in adipose tissue were inconsistent. Functional capacity enhancements—such as improved handgrip strength and 10-meter walk test performance—were observed in some trials, especially those using whey or leucine-enriched protein supplements. However, findings on VO₂ peak, a key indicator of exercise capacity, were inconclusive, some trials reporting improvements while others showed no significant effect. Risk of bias varied from low to high across trials, and heterogeneity in intervention types, protein dosages, and study durations limited direct comparisons. Outcomes classified with very low certainty of evidence included body mass index, the 6-minute walk test, and VO₂ peak or maximum. Meanwhile, low-certainty evidence was found for handgrip strength, fat mass, and lean body mass. In conclusion, while protein supplementation may support improvements in body composition and functional capacity, variability in protein types and dosages prevents a clear recommendation for CVD patients in cardiovascular rehabilitation. Further high-quality trials with larger sample sizes are needed to establish more specific protein intake guidelines for this population.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"136 ","pages":"Article 112773"},"PeriodicalIF":3.2,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143928029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modulation of snack foods: An approach to overcome hidden hunger in children","authors":"Sana Manzoor ,&nbsp;Ammar B. Altemim ,&nbsp;Allah Rakha ,&nbsp;Hina Rasheed ,&nbsp;Muhammad Shaffay Ali Khan ,&nbsp;Seemal Munir ,&nbsp;Zuhaib F. Bhat ,&nbsp;Rana Muhammad Aadil","doi":"10.1016/j.nut.2025.112777","DOIUrl":"10.1016/j.nut.2025.112777","url":null,"abstract":"<div><div>The global snack foods market had grown to 585 billion USD by 2022. Consumption of snacks has gained attention at a commercial level since they are liked by people of all ages, including millennials and elderly people. An increasing trend in snacking provides a potential opportunity for delivering micronutrients to minimize hidden hunger throughout the world. Various strategies are proposed in this review for modifying these snacks to improve snacking. The practical implications, including methodologies and approaches of such strategies, have also been summarized. The raw materials used for snack development can be biofortified for additional mineral content. By-products of fruits and vegetables can be used as ingredients and nutrient sources in the food industry. Organic salts, industrial fortificants, and nutritive substitutes can be used in extrusion processing as an enrichment method. Snacks can also be reformulated to contain more nutrients. Such strategies could greatly improve not only individual health but also the global market.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"135 ","pages":"Article 112777"},"PeriodicalIF":3.2,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143878496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of loss of visceral adipose tissue after concurrent chemoradiotherapy with poor survival in patients with head and neck squamous cell carcinoma","authors":"Sang Mi Lee M.D., Ph.D. ,&nbsp;In Young Jo M.D., Ph.D. ,&nbsp;Jae Hong Park M.D., Ph.D. ,&nbsp;Min-Su Kim M.D., Ph.D. ,&nbsp;Hye Jeong Choi M.D., Ph.D. ,&nbsp;Jeong Won Lee M.D., Ph.D. ,&nbsp;Su Jin Jang M.D., Ph.D.","doi":"10.1016/j.nut.2025.112775","DOIUrl":"10.1016/j.nut.2025.112775","url":null,"abstract":"<div><h3>Objectives</h3><div>Nutritional status is known to be associated with clinical outcomes in head and neck squamous cell carcinoma (HNSCC) patients. The aim of this study was to investigate whether changes in subcutaneous (SAT) and visceral (VAT) adipose tissue mass after concurrent chemoradiotherapy (CCRT) are significantly related to progression-free survival (PFS) and overall survival (OS) in HNSCC patients.</div></div><div><h3>Methods</h3><div>117 HNSCC patients who underwent definitive CCRT were retrospecitively analyzed. Using unenhanced computed tomography images from pretreatment (PET1) and 3 months post-CCRT (PET2) F-18 fluorodeoxyglucose positron emission tomography (PET)/computed tomography scans, we measured the cross-sectional areas of SAT and VAT. The areas of SAT and VAT were adjusted for height squared to calculate the SAT and VAT indices.</div></div><div><h3>Results</h3><div>Following CCRT, 92 patients (78.6%) exhibited a decrease in VAT index values. The complete metabolic response (CMR) patient group showed significantly higher values of VAT index at PET2 compared to the non-CMR group (<em>P</em> &lt; 0.05). Multivariate survival analysis found that the VAT index at PET2 and the percent changes in both the SAT index and VAT index were significant predictors for both PFS and OS (<em>P</em> &lt; 0.05). Patients with a low VAT index at PET2 and marked losses of SAT index and VAT index after CCRT had poorer survival outcomes. On subgroup survival analysis, the percent change in VAT index was a significant predictor for PFS and OS in both CMR and non-CMR groups (<em>P</em> &lt; 0.05).</div></div><div><h3>Conclusions</h3><div>The alteration in VAT mass after CCRT was clinically significant for risk stratification of survival outcomes in HNSCC patients.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"136 ","pages":"Article 112775"},"PeriodicalIF":3.2,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143928030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of 8-hour time-restricted eating combined with different dietary patterns on body composition, lipid metabolism, and oxidative stress in healthy adults: An exploratory study from an RCT","authors":"Xinzheng Liang MD ,&nbsp;Yuanchen Zhou MD ,&nbsp;Youjia Kong MS ,&nbsp;Jixiang Liu MD ,&nbsp;Kaimin Li MD ,&nbsp;Lijun Xue MD ,&nbsp;Shukun Yao MD, PhD","doi":"10.1016/j.nut.2025.112776","DOIUrl":"10.1016/j.nut.2025.112776","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate the effectiveness of a 4-week intervention of time-restricted eating (TRE) alone or in combination with an elimination of ultra-processed foods or vegetarian diet, on body composition, lipid metabolism, and oxidative stress.</div></div><div><h3>Methods</h3><div>This was a randomized controlled trial including 70 participants comparing three diet groups maintained for a 4-week period: A, TRE alone; B, TRE with elimination of ultra-processed foods; and C, TRE with a vegetarian diet. Per-protocol analyses of body composition, plasma lipid levels, and oxidative stress markers were performed.</div></div><div><h3>Results</h3><div>Compared to baseline, Group B significantly reduced weight (<em>P</em> = 0.02), body mass index, waist and hip circumference, as well as fat ratio, total cholesterol, 4-hydroxynonenal an 8-Iso prostaglandin F 2α (all <em>P</em> &lt; 0.05). Group B also increased high-density lipoprotein cholesterol (<em>P</em> &lt; 0.05) and catalase (<em>P</em> = 0.002). Compared to Group A, Group B was more effective in decreasing body mass index (Δ: –0.1 ± 0.7 vs. –0.2 ± 0.3, respectively, <em>P</em> = 0.041) and waist circumference (Δ: –1.1 ± 4.0 vs. –3.5 ± 4.4, <em>P</em> &lt; 0.001). Compared to Group A and B, the increase in superoxide dismutase (Δ: 12.74 ± 8.34, <em>P</em> &lt; 0.05) and glutathione (Δ: 0.63 ± 0.40, <em>P</em> &lt; 0.05) was significantly greater for Group C. Group C also produced a greater decrease in malondialdehyde (Δ: –0.79 ± 0.28) than the Group A (Δ: –0.32 ± 0.51, <em>P</em> &lt; 0.001) and Group B (Δ: –0.20 ± 0.68, <em>P</em> &lt; 0.001) diets.</div></div><div><h3>Conclusions</h3><div>Consumption of ultra-processed foods can increase body composition and lipid profile, despite TRE. A vegetarian diet in combination with TRE is effective in reducing oxidative stress injury.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"136 ","pages":"Article 112776"},"PeriodicalIF":3.2,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143890998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improved appendicular muscle strength predicts lower mortality in patients with heart failure","authors":"Takumi Noda P.T., Ph.D. ,&nbsp;Kentaro Kamiya P.T., Ph.D. ,&nbsp;Nobuaki Hamazaki P.T., Ph.D. ,&nbsp;Takashi Miki P.T., M.Sc. ,&nbsp;Kohei Nozaki P.T., Ph.D. ,&nbsp;Takafumi Ichikawa P.T. ,&nbsp;Masashi Yamashita P.T., Ph.D. ,&nbsp;Shota Uchida P.T., Ph.D. ,&nbsp;Kensuke Ueno P.T., Ph.D. ,&nbsp;Emi Maekawa M.D., Ph.D. ,&nbsp;Tasuku Terada C.E.P., Ph.D. ,&nbsp;Jennifer L. Reed R.Kin., Ph.D. ,&nbsp;Minako Yamaoka-Tojo M.D., Ph.D. ,&nbsp;Atsuhiko Matsunaga P.T., Ph.D. ,&nbsp;Junya Ako M.D., Ph.D.","doi":"10.1016/j.nut.2025.112774","DOIUrl":"10.1016/j.nut.2025.112774","url":null,"abstract":"<div><h3>Background</h3><div>A decrease in general muscle strength is associated with a poor prognosis and lower physical function in patients with heart failure (HF). We examined whether improved appendicular muscle weakness (dynapenia) conditions would predict a better prognosis and improved physical functions in patients with HF.</div></div><div><h3>Methods</h3><div>Handgrip and leg strength were assessed before discharge (baseline) and after outpatient cardiac rehabilitation (CR) (follow-up), based on which patients were divided into four dynapenia conditions: non-dynapenia at baseline/follow-up, dynapenia at baseline/non-dynapenia at follow-up, non-dynapenia at baseline/dynapenia at follow-up, and dynapenia at baseline/follow-up. Cox regression and mixed-effects analyses were performed to examine associations between changes in the dynapenia condition and all-cause mortality and physical functions (6-minute walking distance and gait speed).</div></div><div><h3>Results</h3><div>Of 607 patients included in the analyses (median age 70 years, 64% male), 92 patients died during the follow-up period (median 2.81 years). The dynapenia at baseline/follow-up group (adjusted hazard ratio [aHR]: 1.936, 95% confidence interval [CI]: 1.086–3.451) and non-dynapenia at baseline/dynapenia at follow-up group (aHR: 2.442, 95% CI: 1.032–5.766) had higher mortality rates compared to the non-dynapenia at baseline/follow-up group. The mortality risk was not different between the group with dynapenia at baseline/non-dynapenia at follow-up (aHR: 1.270, 95% CI: 0.670–2.409) and the group with non-dynapenia at baseline/follow-up. Improved dynapenia conditions were associated with increased 6-minute walking distance (<em>p</em> = 0.004) but not significantly associated with gait speed (<em>p</em> = 0.173).</div></div><div><h3>Conclusions</h3><div>Dynapenia following CR is associated with a higher risk of mortality and lower exercise capacity in patients with HF.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"136 ","pages":"Article 112774"},"PeriodicalIF":3.2,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143890999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}