Nutrition最新文献

{"title":"Evaluation of therapeutic education on intermittent fasting in patients with secondary adrenal insufficiency: A clinical trial","authors":"Melika Chihaoui M.D.,&nbsp;Mariam Mabrouk M.D.,&nbsp;Ibtissem Oueslati M.D.,&nbsp;Nadia Khessairi M.D.,&nbsp;Fatma Chaker M.D.,&nbsp;Meriem Yazidi M.D.","doi":"10.1016/j.nut.2025.112688","DOIUrl":"10.1016/j.nut.2025.112688","url":null,"abstract":"<div><h3>Objectives</h3><div>Intermittent fasting was associated with complications in patients with adrenal insufficiency (AI). The study aimed to evaluate the impact of therapeutic education and drug adjustment on Ramadan fasting outcomes in patients with secondary AI (SAI).</div></div><div><h3>Methods</h3><div>A case-control prospective interventional study including patients with SAI willing to fast Ramadan 2023, and age-, gender-, and body mass index-matched healthy fasting controls. Before Ramadan, clinical examination, education for lifestyle measures, and hydrocortisone intake adjustment were performed. The occurrence of complications and the number of fasted days during Ramadan 2023 were reported and compared with those of Ramadan 2022 in patients and controls.</div></div><div><h3>Results</h3><div>A total of 50 patients; 33 women, median age: 43 years (34–55), median duration of SAI: 7.5 years (4–12.5), and 100 controls were enrolled, and fasted in 2023. Thirty-four patients and 100 controls fasted in 2022, corresponding to a 32% increase in fasting patients. Compared to 2022, there was a significant decrease in the frequency of complications in 2023 in patients compared to controls. The number of fasted days did not change. No severe event happened during the 2023 fasting. In patients, apart from the age that was higher in former fasters compared to new fasters, age, gender, body mass index, blood pressure levels, renal clearance, disease duration, and daily hydrocortisone dose were not associated with new versus former fasters, high versus low-risk patients, or incomplete versus complete month fasters.</div></div><div><h3>Conclusions</h3><div>Therapeutic education enabled more patients with SAI to fast and reduced the frequency of complications during fasting. Registered on “clinical trials.gov,” April 12, 2023, under the identifier ID: NCT05827965.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"132 ","pages":"Article 112688"},"PeriodicalIF":3.2,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143378606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation analysis on the association of composite dietary antioxidant index with serum cotinine levels in the general adult population","authors":"Ning Zhu M.D. ,&nbsp;Zhongbo Chen M.D. ,&nbsp;Xuechan Yu M.D.,&nbsp;Jingjing Hu M.D.,&nbsp;Linfeng Wang M.D.,&nbsp;Chao Cao Ph.D.","doi":"10.1016/j.nut.2025.112687","DOIUrl":"10.1016/j.nut.2025.112687","url":null,"abstract":"<div><h3>Objectives</h3><div>This study utilized data from the National Health and Nutrition Examination Survey (1999–2020) to explore the relationship between dietary antioxidant intake and serum cotinine levels among US adults.</div></div><div><h3>Methods</h3><div>A total of 41 132 participants were included after exclusions. The composite dietary antioxidant index (CDAI), incorporating vitamins A, C, and E, zinc, selenium, and carotenoids, was derived from 24-hour dietary recalls. Associations were assessed using multiple linear regression and weighted quantile sum models.</div></div><div><h3>Results</h3><div>Higher CDAI quartiles were significantly associated with lower serum cotinine levels in the overall population, indicated by a <em>β</em> coefficient of –0.42 (95% confidence interval [CI]: –0.51, –0.33). Subgroup analyses revealed that Quartile 4 showed an inverse association with serum cotinine levels compared to Quartile 1 (<em>β</em> = –0.34, 95% CI: –0.45, –0.23; <em>P</em> &lt; 0.001) among never-smokers, with stronger effects observed among former and current smokers. Specifically, among former smokers, Quartile 4 exhibited a <em>β</em> coefficient of –0.53 (95% CI: –0.77, –0.30; <em>P</em> &lt; 0.001), and among current smokers (<em>n</em> = 8280), Quartile 4 had a <em>β</em> coefficient of –0.44 (95% CI: –0.58, –0.30; <em>P</em> &lt; 0.001). Importantly, no significant interaction was observed between CDAI and smoking status. Weighted quantile sum analysis demonstrated a negative association between combined antioxidant intake and cotinine levels (<em>β</em> = –0.073 [–0.087, –0.059], <em>P</em> &lt; 0.001), with vitamin A exerting the most significant influence (36.30%).</div></div><div><h3>Conclusions</h3><div>Higher dietary antioxidant intake, particularly vitamin A, is associated with lower serum cotinine levels, suggesting potential protective effects against tobacco exposure in US adults. Future research should focus on longitudinal studies to examine the potential role of dietary antioxidants in mitigating the effects of tobacco exposure.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"132 ","pages":"Article 112687"},"PeriodicalIF":3.2,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143396059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive frailty, physical frailty, and malnutrition","authors":"Tomoyuki Kawada M.D.","doi":"10.1016/j.nut.2025.112683","DOIUrl":"10.1016/j.nut.2025.112683","url":null,"abstract":"","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"132 ","pages":"Article 112683"},"PeriodicalIF":3.2,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143067130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author's response to comment re. “Portable Bioimpedance Analyzer for Remote Body Composition Monitoring: A Clinical Investigation Under Controlled Conditions”","authors":"Elisa Mazza,&nbsp;Samantha Maurotti,&nbsp;Yvelise Ferro,&nbsp;Paola Doria,&nbsp;Marta Moraca,&nbsp;Tiziana Montalcini,&nbsp;Arturo Pujia","doi":"10.1016/j.nut.2024.112678","DOIUrl":"10.1016/j.nut.2024.112678","url":null,"abstract":"","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"132 ","pages":"Article 112678"},"PeriodicalIF":3.2,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-stratified validation and interrater reliability of the screening tool for nutritional risk for childhood cancer in hospitalized children","authors":"Alda Daniela García-Guzmán M.Sc. ,&nbsp;Liliana Velasco-Hidalgo M.D. ,&nbsp;Salvador Ortiz-Gutiérrez M.Sc. ,&nbsp;Diana Monserrat Aquino-Luna B.Sc. ,&nbsp;Sandra Nayeli Becerra-Morales M.D. ,&nbsp;Kenya Shamira Carmona-Jaimez M.D. ,&nbsp;Martha Guevara-Cruz Ph.D. ,&nbsp;Beatriz Adriana Pinzón-Navarro M.Sc. ,&nbsp;Daffne Danae Baldwin-Monroy M.Sc. ,&nbsp;Rocío del Socorro Cárdenas-Cardos M.D. ,&nbsp;Marta Margarita Zapata-Tarrés Ph.D. ,&nbsp;Isabel Medina-Vera Ph.D.","doi":"10.1016/j.nut.2025.112685","DOIUrl":"10.1016/j.nut.2025.112685","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the reliability, construct, and criterion validity of the screening tool for childhood cancer (SCAN), stratified by age in oncology patients admitted to a tertiary referral hospital.</div></div><div><h3>Methods</h3><div>Hospitalized children from birth to 18 years old, with an oncological diagnosis and expected length of stay (LOS) of &gt;24 hours were included. Interrater and intrarrater agreements were used to evaluate the reliability of SCAN. Construct validity and criterion validity were explored in SCAN. Also, predictive validity was explored by comparing SCAN risk categories against LOS.</div></div><div><h3>Results</h3><div>Three hundred ninety-four children were included in the study. The scores obtained after dietitians and physicians used SCAN showed good agreement (ICC = 0.80, 95%CI 0.71–0.86, <em>P &lt; 0.</em>001). The intrarrater agreement within the evaluation of the same dietitian to the same group of patients was also good (ICC = 0.83, 95%CI 0.75–0.88, <em>P &lt; 0.</em>001). After applying SCAN, 66.2% of participants scored &gt;3 points, classified as at risk of malnutrition. The agreement observed when comparing the risk classification given by the tool with the malnutrition assessment using anthropometry variables as the criterion reference was fair (κ = 0.22, 95%CI 0.15–0.29, <em>P &lt; 0.</em>001). Predictive validity indicated a slight agreement (κ = 0.16, 95%CI 0.08–0.25, <em>P &lt; 0.</em>001) between malnutrition risk by SCAN and LOS. When assessing construct validity, comparing the scores given by SCAN with those provided by STRONGkids, a fair agreement was found (κ = 0.21, 95%CI 0.15–0.26, <em>P &lt; 0.</em>001).</div></div><div><h3>Conclusions</h3><div>Our results show that SCAN is a reliable and valid tool for detecting malnutrition in oncology pediatric patients upon hospital admission.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"132 ","pages":"Article 112685"},"PeriodicalIF":3.2,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Water turnover estimated by prediction equation and all-cause and cause-specific mortality in Japan: A cross-sectional prefecture-level ecological study","authors":"Daiki Watanabe R.D., Ph.D. ,&nbsp;Yumiko Inoue R.D., M.S. ,&nbsp;Motohiko Miyachi Ph.D.","doi":"10.1016/j.nut.2025.112684","DOIUrl":"10.1016/j.nut.2025.112684","url":null,"abstract":"<div><h3>Objective</h3><div>Although water is essential for maintaining life and health, the association of water turnover (WT) with mortality is, to our knowledge, unknown. We aimed to 1) determine the annual mean and variance of WT and 2) evaluate the association between WT and mortality in all 47 prefectures in Japan.</div></div><div><h3>Methods</h3><div>This cross-sectional, prefecture-level ecological study used data from government surveys that provided prefecture-level data. WT was calculated considering lifestyle and environmental factors using an equation previously developed by the international doubly labeled water database group. Each prefecture was classified into a WT quartile. We obtained data on age-standardized mortality from the 2015 Vital Statistics. The mortality rate ratio (RR) was calculated using a multivariable Poisson regression model.</div></div><div><h3>Results</h3><div>The annual mean and variance of WT were 3771 and 990 mL/d in men and 3084 and 990 mL/d in women, respectively. After adjusting for confounders, compared to the prefecture in the highest WT quartile, those in the lowest WT quartile were associated with a higher mortality RR for all-cause (Men: RR = 1.07 [95% confidence interval (CI) = 1.02–1.11]; Women: RR = 1.05 [95% CI = 1.00–1.11]) and stroke (Men: RR = 1.16 [95% CI = 1.00–1.33]; Women: RR = 1.18 [95% CI = 1.01–1.42]). This association was moderately weaker when adjusted for exercise habits, especially among women.</div></div><div><h3>Conclusions</h3><div>Our findings indicate large regional and seasonal variations in WT in Japan and that the risk of excess death due to lower WT may be partially explained by physical activity.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"132 ","pages":"Article 112684"},"PeriodicalIF":3.2,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of computed tomography body composition in patients with locally progressive gastric cancer undergoing radical surgery combined with prophylactic hyperthermic intraperitoneal chemotherapy","authors":"Wenzhi Wu M.Sc. ,&nbsp;Ruiqing Liu M.D. ,&nbsp;Dongsheng Wang M.D. ,&nbsp;Yu Li M.D. ,&nbsp;Wenchang Yang M.D. ,&nbsp;Zheng Ma M.D. ,&nbsp;Liang Wang M.Sc. ,&nbsp;Simeng Zhang M.Sc. ,&nbsp;Zongsheng Sun M.Sc. ,&nbsp;Maoshen Zhang M.D. ,&nbsp;Xianxiang Zhang M.D.","doi":"10.1016/j.nut.2025.112686","DOIUrl":"10.1016/j.nut.2025.112686","url":null,"abstract":"<div><h3>Objectives</h3><div>Radical resection combined with prophylactic hyperthermic intraperitoneal chemotherapy (p-HIPEC) is a promising treatment for locally advanced gastric cancer (LAGC), though factors influencing its long-term benefits remain unclear. This study aimed to assess the impact of computed tomography (CT)-based body composition parameters on survival in patients undergoing this combination treatment, exploring nutritional factors affecting long-term survival and developing a prognostic model.</div></div><div><h3>Methods</h3><div>We retrospectively analyzed clinical and CT data from 230 patients with LAGC who underwent radical resection with p-HIPEC between January 2017 and December 2020. Cox regression and Kaplan-Meier analysis were used to identify independent risk factors, and nomograms were constructed based on significant predictors. The models' accuracy was evaluated using receiver operating characteristic (ROC) curves and calibration plots.</div></div><div><h3>Results</h3><div>Of the 230 patients, the 3-year survival rate was 56.1%, with a median overall survival of 49.7 months. Multivariate analysis identified sarcopenia (hazard ratio [HR], 3.078; <em>p</em> &lt; 0.001), low subcutaneous adipose tissue index (HR, 1.739; <em>p</em> = 0.002), high visceral-to-subcutaneous adipose tissue ratio (HR, 1.746; <em>p</em> = 0.002), pT stage (<em>p</em> &lt; 0.001), pN stage (N3: <em>p</em> = 0.004; N2: <em>p</em> = 0.049), and vascular invasion (<em>p</em> &lt; 0.001) as independent risk factors for poor survival. Nomograms incorporating body composition and tumor features predicted 1-, 3-, and 5-year overall survival with high accuracy (AUC &gt;0.7).</div></div><div><h3>Conclusions</h3><div>Body composition and tumor characteristics are independent predictors of overall survival in LAGC patients. Nomograms integrating these factors provide reliable prognostic predictions.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"132 ","pages":"Article 112686"},"PeriodicalIF":3.2,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adherence to a gluten-free diet, depression, and nutrient distribution in participants with celiac disease","authors":"Mohammad K. Shushari ,&nbsp;Tianlan Wei ,&nbsp;Jialin Zhang ,&nbsp;Diane K. Tidwell ,&nbsp;Amanda Conard ,&nbsp;Terezie Tolar-Peterson","doi":"10.1016/j.nut.2024.112676","DOIUrl":"10.1016/j.nut.2024.112676","url":null,"abstract":"<div><h3>Background</h3><div>Celiac disease (CD) presents formidable challenges, requiring rigorous adherence to a gluten-free diet (GFD)</div></div><div><h3>Aim</h3><div>In this study we probed the impact of GFD on depression in people with CD, analyzing depression prevalence across diverse backgrounds and scrutinizing the distribution of macro- and micronutrients.</div></div><div><h3>Methods</h3><div>Comprehensive data spanning National Health and Nutrition Examination Survey cycles (2009–2014) encompassed 70 CD participants and 271 individuals reporting general gluten issues. Employing SAS v9.4, merged cycles were scrutinized using unique identifiers, bolstered by sample weight and study design that reduced bias.</div></div><div><h3>Results</h3><div>While linear regression uncovered no significant depression, CD/GFD link and ethnicity exhibited notable significance. CD prevalence registered at 0.12 in Whites, a striking 3 to 6 times higher compared to other ethnic groups, with females encountering twice the prevalence. Nutritional deficits surfaced within both CD and GFD contexts, inclusive of negative correlations between carbohydrate intake and CD/GFD. The GFD cohort displayed reduced PUFA consumption, while deficiencies in essential micronutrients, encompassing Vitamins B1, D, and E, as well as calcium, also emerged prominently with the GDF group.</div></div><div><h3>Conclusion</h3><div>This study delved into the intricate interplay of dietary, mental health, and CD factors, furnishing comprehensive insights and a holistic framework for optimal management strategies for CD patients.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"132 ","pages":"Article 112676"},"PeriodicalIF":3.2,"publicationDate":"2025-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143235219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Washed microbiota transplantation effectively improves nutritional status in gastrointestinal disease–related malnourished children","authors":"Yuyan Xiao ,&nbsp;Xinyi He ,&nbsp;Hui Zhang ,&nbsp;Xia Wu ,&nbsp;Rujun Ai ,&nbsp;Jie Xu ,&nbsp;Quan Wen ,&nbsp;Faming Zhang ,&nbsp;Bota Cui","doi":"10.1016/j.nut.2024.112679","DOIUrl":"10.1016/j.nut.2024.112679","url":null,"abstract":"<div><h3>Background and aim</h3><div>Gut microbiota dysbiosis plays a critical role in malnutrition caused by food intolerance and intestinal inflammation in children, which needs to be addressed. We assessed the efficacy and safety of washed microbiota transplantation (WMT) for gastrointestinal disease–related malnourished children.</div></div><div><h3>Methods</h3><div>This was a prospective observational study involving gastrointestinal disease–related malnourished pediatric patients who underwent WMT. The primary outcome was the clinical response rate at 3 mo post-WMT. Clinical response was defined as an improvement in the children's nutritional status of one level or more. The secondary outcomes were changes in gastrointestinal symptoms, laboratory nutritional indicators, and adverse events during the WMT procedure.</div></div><div><h3>Results</h3><div>29 patients undergoing 74 WMTs were included for analysis. In total, 48.3% (14/29) of patients achieved clinical response post-WMT. Gastrointestinal symptoms, including diarrhea, mucous stool, abdominal pain, abdominal distention, and hematochezia, were significantly relieved post-WMT (all <em>P</em> &lt; 0.05). Serum albumin and prealbumin levels were increased significantly post-WMT (<em>P</em> = 0.028 and 0.028, respectively). Eight self-limiting and transient adverse events, including diarrhea, abdominal pain, and abdominal distension, occurred after WMT.</div></div><div><h3>Conclusion</h3><div>This study indicated that WMT might be effective and safe for improving nutritional status and gastrointestinal symptoms in gastrointestinal disease–related malnourished children at 3-mo follow-up. WMT was expected to be a new therapeutic option for these patients.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"132 ","pages":"Article 112679"},"PeriodicalIF":3.2,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143040308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fiber, lactose and fat-modified diet for the prevention of gastrointestinal chemo-radiotherapy-induced toxicity in patients with cervical cancer: Randomized clinical trial","authors":"Laura Flores-Cisneros Ph.D. ,&nbsp;Lucely Cetina-Pérez Ph.D. ,&nbsp;Julissa Luvián-Morales Ph.D. ,&nbsp;Tatiana Galicia-Carmona M.D. ,&nbsp;Roberto Jiménez-Morales M.Sc. ,&nbsp;Miriam Sánchez-López M.Sc. ,&nbsp;Lilia Castillo-Martínez Ph.D.","doi":"10.1016/j.nut.2024.112682","DOIUrl":"10.1016/j.nut.2024.112682","url":null,"abstract":"<div><h3>Background</h3><div>The most frequent early gastrointestinal (GI) toxicity symptoms are nausea (58%), diarrhea (46.7%), and vomiting (45.5%) in patients with cervical cancer (CC). Approximately 90% of patients undergoing abdominopelvic radiotherapy present with changes in the GI tract, such as degenerative alterations in mucosal epithelial cells and nutrient malabsorption.</div></div><div><h3>Objective</h3><div>To evaluate the effect of a diet modified in fiber, lactose, and fat on the prevention of chemoradiotherapy (QTRT)-induced GI toxicity compared to the usual prescription in women with locally advanced CC.</div></div><div><h3>Methods</h3><div>A total of 134 women with a confirmed diagnosis of CC in locally advanced stages (IB2-IVA) were included in a randomized clinical trial conducted between February 2017 and March 2020. The intervention group (IG) received a modified diet of fiber, lactose, and fat, while the usual prescription group (UP) followed habitual nutritional recommendations. Toxicity was measured using the Common Terminology Criteria for Adverse Events (CTCAE) v4.</div></div><div><h3>Results</h3><div>A total of 134 women were included in the IG (65) and UP (69) groups. The mean age in the IG and UP groups were 47.2±13.4 and 49.7±14.2 years, respectively. Radiotherapy doses received by the IG and UP groups were 50.1±6.7 and 49.9±4.6 Gy, respectively. IG had a lower risk of presenting with mild constipation compared to the UP (hazard ratio: 0.46, 95% confidence interval: 0.28–0.76, <em>P</em>&lt;0.01).</div></div><div><h3>Conclusion</h3><div>Patients with locally advanced stages of CC undergoing QTRT who received fiber, lactose, and fat-modified diet may have a lower risk of mild constipation during abdominal radiotherapy.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"132 ","pages":"Article 112682"},"PeriodicalIF":3.2,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}