Nutrition最新文献

{"title":"Vitamin B12 supplementation attenuates endoplasmic reticulum stress and neuronal cell death in the cerebral cortex of high-fat high-sucrose-fed male mice","authors":"Udaykanth Suryavanshi M.Sc. ,&nbsp;Nagaraju Marka Ph.D. ,&nbsp;Abhiram Charan Tej Mallu Ph.D. ,&nbsp;G. Bhanuprakash Reddy Ph.D. ,&nbsp;V. Sudhakar Reddy Ph.D.","doi":"10.1016/j.nut.2025.112808","DOIUrl":"10.1016/j.nut.2025.112808","url":null,"abstract":"<div><h3>Introduction</h3><div>Increased consumption of a high-calorie diet results in the development of metabolic disorders and associated neurological impairments, ultimately leading to cognitive decline. Metabolic disturbances such as hyperglycaemia, systemic insulin resistance, and hyperhomocysteinemia (HHcy) are linked to neurodegenerative diseases. These conditions share a common pathogenic feature of increased susceptibility to protein misfolding and aggregation, which triggers endoplasmic reticulum (ER) stress. Vitamin B12 is vital for brain health, and its deficiency is associated with HHcy and ER stress. This study investigated the effect of vitamin B12 supplementation on diet-induced metabolic disorder-associated ER stress and neurobehavioral outcomes in mice.</div></div><div><h3>Methods</h3><div>Two-month-old C57BL/6J male mice were randomly assigned to three groups and fed with respective diets for 8 months: Control (C) group (B12: 25 μg/kg diet), HFHS (high-fat, high-sucrose diet; B12: 25 μg/kg), and HFHS+B12 (B12: 50 μg/kg).</div></div><div><h3>Results</h3><div>Fasting blood glucose, glucose tolerance, triglycerides, and total cholesterol were similar across all groups. The HFHS diet led to body weight gain, higher insulin levels, elevated homocysteine (Hcy), and HOMA-IR compared to C group. However, B12 supplementation to HFHS mice significantly reduced Hcy levels compared to HFHS group. Additionally, the HFHS diet resulted in ER stress, neuronal apoptosis and astrogliosis in the cerebral cortex. However, B12 supplementation to HFHS group mitigated ER stress, protected against neuronal cell death, and reduced astrogliosis. Moreover, B12 supplementation enhanced neurotrophic support and reduced anxiety-like behaviour in HFHS+B12 group.</div></div><div><h3>Conclusions</h3><div>Overall, these findings suggest that B12 supplementation confers protection against Hcy-induced ER stress and apoptosis, highlighting its potential as a neuroprotective agent.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"138 ","pages":"Article 112808"},"PeriodicalIF":3.2,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144254144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Omega-3 supplementation increases 13C-EPA but not 13C-DHA kinetics in healthy older adults after 13C-DHA single dose intake: A secondary analysis","authors":"Insaf Loukil M.Sc. ,&nbsp;David Ku B.Sc. ,&nbsp;Annick Vachon M.Sc. ,&nbsp;Adam Metherel Ph.D. ,&nbsp;Mélanie Plourde Ph.D.","doi":"10.1016/j.nut.2025.112803","DOIUrl":"10.1016/j.nut.2025.112803","url":null,"abstract":"<div><h3>Objective</h3><div>To investigated whether post supplementation, ¹³C-DHA is less incorporated into plasma phospholipids (PL) and triglycerides (TG) compared to pre-supplementation considering that these are the two most prominent delivery pools of DHA to tissues.</div></div><div><h3>Methodology</h3><div>Plasma samples from twenty healthy men and women, matched for age and body mass index, were analyzed. Participants received a single oral dose of 40 mg ¹³C-DHA in 2 kinetic studies: 1 prior to and 1 during the last month of supplementation with 3.2 g/day of ω3 PUFA. ¹³C enrichment analyses were performed on plasma samples at baseline, 4, 6, 24 hours, 7 days, and 28 days post-tracer intake. Lipids were extracted, and PL and TG were separated by solid-phase extraction. Quantification of carbon-13 eicosapentaenoic acid (¹³C-EPA) and ¹³C-DHA was performed using gas chromatography-mass spectrometry (GC-MS).</div></div><div><h3>Results</h3><div>The area under the curve (AUC) for ¹³C-DHA in PL and TG did not show statistically significant differences before and during supplementation. However, the AUC for ¹³C-EPA in PL and TG increased by 45% and 48% with supplementation, respectively. This finding was unexpected, as our previous analysis indicated a 60% reduction in plasma ¹³C-DHA levels during supplementation, accompanied by increased β-oxidation. Additionally, there were statistically significant time × gender interactions for ¹³C-EPA and ¹³C-DHA in plasma PL (<em>P</em> &lt; 0.0001), with women exhibiting 90% and 139% higher levels of ¹³C-EPA and ¹³C-DHA over time, respectively. No time × gender interactions were observed for ¹³C-EPA and ¹³C-DHA in plasma TG, although independent time and gender effects were present. Furthermore, there was a time × body mass index interaction for ¹³C-EPA in PL only.</div></div><div><h3>Conclusion</h3><div>This secondary analysis suggests that after supplementation with ω3 PUFA, DHA metabolism is stable while EPA metabolism may be slowed due to factors such as DHA inhibition of EPA elongation and/or reduced plasma clearance, which may indicate the tissues needs for DHA are being met.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"136 ","pages":"Article 112803"},"PeriodicalIF":3.2,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143948557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the interaction between vitamin D pathway gene polymorphisms, vitamin D status, and depression: A population-based study","authors":"Thaís da Silva Sabião Ph.D. ,&nbsp;Luiz Antônio Alves de Menezes-Júnior Ph.D. ,&nbsp;Aline Priscila Batista Ph.D. ,&nbsp;Samara Silva de Moura Ph.D. ,&nbsp;Adriana Lúcia Meireles Ph.D. ,&nbsp;Mariana Carvalho de Menezes Ph.D. ,&nbsp;George Luiz Lins Machado-Coelho Ph.D. ,&nbsp;Júlia Cristina Cardoso Carraro Ph.D.","doi":"10.1016/j.nut.2025.112802","DOIUrl":"10.1016/j.nut.2025.112802","url":null,"abstract":"<div><h3>Background</h3><div>The association between vitamin D and depression is controversial, mainly because of genetic differences and confounding factors.</div></div><div><h3>Objective</h3><div>To evaluate the association between vitamin D and depressive symptoms, considering the influence of genetic variations, skin color, and lifestyle.</div></div><div><h3>Methods</h3><div>This population-based cross-sectional study was conducted during the COVID-19 pandemic. Depressive symptoms were assessed using the Patient Health Questionnaire-9. Vitamin D deficiency was defined as levels of &lt;20 ng/mL in healthy individuals or &lt;30 ng/mL in at-risk groups. A genetic risk score for vitamin D deficiency was developed based on gene polymorphisms involved in vitamin D metabolism (<em>DHCR7, GC</em>, and <em>VDR</em>), and this score was categorized into tertiles.</div></div><div><h3>Results</h3><div>Among 1637 participants, 50.9% were women, with a mean age of 42.9 years (95% CI: 41.62–44.26). No association was found between vitamin D deficiency and depressive symptoms. However, the interaction analysis between vitamin D deficiency and the genetic risk score in the subgroups revealed disparities. Individuals with non-white skin color and vitamin D deficiency in the third tertile, supplement non-users with vitamin D deficiency in the second and third tertiles, and participants with insufficient sun exposure and vitamin D deficiency in the second and third tertiles had a higher prevalence of depressive symptoms.</div></div><div><h3>Conclusion</h3><div>Vitamin D deficiency is linked to a higher prevalence of depressive symptoms in genetically predisposed Brazilians with non-white skin, no vitamin D supplementation, and insufficient sun exposure. Mental health guidelines should aim to promote lifestyle modifications among individuals who are predisposed to depressive symptoms.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"137 ","pages":"Article 112802"},"PeriodicalIF":3.2,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144089937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Excessive dietary saturated fat or fructose and their combination (found in ultra-processed foods) impair mitochondrial dynamics markers and cause brown adipocyte whitening in adult mice","authors":"Jade Sancha de Oliveira Glauser M.Sc.,&nbsp;Daiana Araujo Santana-Oliveira Ph.D.,&nbsp;Flávia Maria Silva-Veiga Ph.D.,&nbsp;Aline Fernandes-da-Silva Ph.D.,&nbsp;Marcia Barbosa Aguila Ph.D.,&nbsp;Vanessa Souza-Mello Ph.D.","doi":"10.1016/j.nut.2025.112805","DOIUrl":"10.1016/j.nut.2025.112805","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the effects of comparable dietary excess of fat or fructose and the combination of these two insults (mimicking ultra-processed foods) on interscapular brown adipose tissue (iBAT) whitening and markers of mitochondrial dynamics in adult male mice.</div></div><div><h3>Methods</h3><div>Male C57BL/6 mice were randomly assigned into four groups according to the diet: control diet (C, following AIN-93M), high-fat diet (HF, 32% energy as lard), high-fructose diet (HFRU, 32% energy as fructose) or for high-fat/high-fructose diet (HF-HFRU, 32% as lard and 32% as fructose) for 12 weeks. Data were tested with one-way ANOVA and Dunnet T3 post-test (n=5 per analysis, significance level <em>P</em> &lt; 0.05).</div></div><div><h3>Results</h3><div>All diets caused insulin resistance and iBAT whitening, albeit with overweight only in the HF and HF-HFRU groups. Principal component analysis indicated that the HFRU scores loaded next to inflammation (<em>Nlrp3</em>) and adipogenesis markers (<em>Pparg</em>), and the HF diet influenced more a mitochondrial gene (<em>Tomm20</em>). However, iBAT whitening in all groups was associated with deficits in mitochondrial dynamics (<em>Ppargc1a, Dnml1</em>, and <em>Pink1</em>), vascularization (<em>Vegfa</em>), and thermogenic markers (<em>Bmp8b</em>, and <em>Ucp1</em>).</div></div><div><h3>Conclusion</h3><div>Similar increases in dietary saturated fat or fructose (32% as energy) and the combination of these two insults (32% / 32%) caused insulin resistance and brown adipocyte dysfunction (whitening) in adult mice after 12 weeks independent of being overweight. In comparison, the PC scores of the HFRU groups were closer to the HF-HFRU group than the HF group, implying a worse outcome and highlighting the importance of limiting saturated fat and fructose intake from ultra-processed foods.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"137 ","pages":"Article 112805"},"PeriodicalIF":3.2,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143947649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional status is associated with cognition and grip strength among older adults: A 10-y longitudinal study in Ghana and South Africa","authors":"Barbara Corso Ph.D. ,&nbsp;Kofi Awuviry-Newton Ph.D. ,&nbsp;Seth Christopher Yaw Appiah Ph.D. ,&nbsp;Daniel Doh Ph.D. ,&nbsp;Paul Kowal Ph.D. ,&nbsp;Karen E. Charlton Ph.D., F.D.A.","doi":"10.1016/j.nut.2025.112798","DOIUrl":"10.1016/j.nut.2025.112798","url":null,"abstract":"<div><h3>Objectives</h3><div>The current study examined the association between nutritional status and changes in cognition and grip strength among older Ghanaian and South African adults over time using three waves of data from the WHO Study on global AGEing and adult health (SAGE).</div></div><div><h3>Methods</h3><div>In total, 6113 and 3623 records of adults aged 60+ y were assessed from Ghanaian and South African datasets, respectively. These were extracted from three waves of the SAGE, conducted between 2007 and 2019. The six-item Mini Nutritional Assessment–Short Form questionnaire, five cognitive performance tests, and dynamometer were used to measure nutritional status, cognition, and handgrip strength, respectively. Data were analyzed by one-way analysis of variance and linear mixed models.</div></div><div><h3>Results</h3><div>After adjusting for all significant covariates, participants at risk of malnutrition (Ghana 3.05 [Standard error (SE) = 0.56], <em>P</em> &lt; 0.0001; South Africa 3.79 [SE = 1.58], <em>P</em> = 0.016) and those with adequate nutritional status (Ghana 6.36 [SE = 0.59], <em>P</em> &lt; 0.0001; South Africa 8.30 [SE = 1.56], <em>P</em> &lt; 0.0001) had significantly higher cognitive scores compared with malnourished participants. In both Ghana and South Africa, handgrip strength was significantly different between the categories of nutritional status in all three study waves (analysis of variance Ghana W1: <em>P</em> &lt; 0.0001, W2: <em>P</em> = 0.0007, W3: <em>P</em> = 0.0043; South Africa <em>P</em> &lt; 0.0001 for all). Significantly higher handgrip strength was measured in participants either classified at risk of malnutrition (Ghana; 2.69 [SE = 0.47], <em>P</em> &lt; 0.0001; South Africa; 4.18 [SE = 2.02], <em>P</em> = 0.038) or those with adequate nutritional status (Ghana; 4.27 [SE = 0.51], <em>P</em> &lt; 0.0001; South Africa; 9.76 [SE = 1.97], <em>P</em> &lt; 0.0001) compared with participants classified as malnourished in both countries. After adjustment for covariates, these differences remained significant in Ghana, but only for those with adequate nutritional status in South Africa.</div></div><div><h3>Conclusions</h3><div>This study confirmed a positive longitudinal association between nutritional status and both cognitive function and hand grip strength for older adults in Ghana and South Africa. These findings highlight the importance of nutritional intervention to promote access to adequate, nutritious diets as people in low- and middle-income countries age.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"136 ","pages":"Article 112798"},"PeriodicalIF":3.2,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144069121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of tableware to improve eating behavior and cardiometabolic health: A systematic review and meta-analysis","authors":"Yiyun Zhang Bachelor ,&nbsp;Tianxue Long Bachelor ,&nbsp;Jing Huang Master ,&nbsp;Dan Zhang Bachelor ,&nbsp;Xiaojing Guo Master ,&nbsp;Mingzi Li","doi":"10.1016/j.nut.2025.112797","DOIUrl":"10.1016/j.nut.2025.112797","url":null,"abstract":"<div><h3>Introduction</h3><div>This study determined whether tableware-based intervention promotes healthy eating behavior and address cardiometabolic risk factors.</div></div><div><h3>Methods</h3><div>PubMed, Web of Science, Scopus, Embase, ClinicalTrials.gov, and ICTRP were searched from the earliest date available to July 2024. Data were pooled to calculate mean differences and 95% confidence intervals using a random or fixed effect model. This study was registered with PROSPERO (CRD42024573343).</div></div><div><h3>Results</h3><div>Twenty-seven publications with 5319 participants were included in this review. The effectiveness of tableware was mostly evaluated through plate models, followed by lunchboxes, forks, spoons, placemats, and take-out containers. Tableware significantly reduced bite rate (<em>d</em> = –1.04 bites per minute), protein intake (<em>d</em> = –14.13 g), and starch intake (<em>d</em> = –26.27 g), body weight (<em>d</em> = –1.24 kg), body mass index (<em>d</em> = –0.41 kg/m²), waist circumference (<em>d</em> = –1.24 cm), HbA1c (<em>d</em> = –0.41%), 2-hour postprandial glucose (<em>d</em> = –2.47 mmol/L), and high-density lipoprotein cholesterol (<em>d</em> = –1.61 mg/dL). Tableware significantly increased the proportion of vegetables taken (<em>d</em> = 5%), with a positive trend for increasing meal duration and fruit intakes. Tableware had no significant effect on blood pressure, total cholesterol, triglycerides, low-density lipoprotein, and fasting blood glucose (unless 12 months duration).</div></div><div><h3>Conclusions</h3><div>Tableware might be a practical tool to promote healthy food choices and weight loss, address fast eating, and improve cardiometabolic health across populations of various age groups.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"137 ","pages":"Article 112797"},"PeriodicalIF":3.2,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144115598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered free fatty acids levels and the onset of metabolic syndrome in childhood cancer survivors","authors":"Katarzyna Konończuk M.D., Ph.D. ,&nbsp;Katarzyna Muszyńska-Rosłan M.D., Ph.D. ,&nbsp;Karolina Konstantynowicz-Nowicka Ph.D. ,&nbsp;Adrian Chabowski M.D., Ph.D. ,&nbsp;Eryk Latoch M.D., Ph.D.","doi":"10.1016/j.nut.2025.112799","DOIUrl":"10.1016/j.nut.2025.112799","url":null,"abstract":"<div><div>Childhood cancer survivors (CCS) are at increased risk for various health issues, including obesity, insulin resistance, hypertension, and dyslipidemia, resulting in the development of metabolic syndrome (MetS) later in life. It has been suggested that anticancer treatment may lead to alterations in lipid metabolism, which play a role in the pathogenesis of metabolic syndrome among CCS. The prospective study included 110 CCS, with a follow-up time of 6.39 years since the end of treatment. Fasting serum of fourteen fatty acids concentrations were measured in all children using gas-liquid chromatography. Among the study group, 41 CCS (37%) met 1 or more criteria for metabolic syndrome and exhibited higher concentrations of myristic (<em>P</em> = 0.002), palmitic (<em>P</em> = 0.003), stearic (<em>P</em> = 0.017), oleic (<em>P</em> = 0. 019), arachidonic (<em>P</em> = 0.002), lignoceric (<em>P</em> = 0.005), docosahexaenoic (<em>P</em> = 0.005), and total fatty acids compared to CCS without metabolic syndrome factors. Additionally, overweight or obese CCS presented higher levels of myristic (<em>P</em> = 0.048), palmitic (<em>P</em> = 0.016), oleopalmitic (<em>P</em> = 0.019), stearic (<em>P</em> = 0.024), oleic (<em>P</em> = 0.020), α-linoleic (<em>P</em> = 0.023) and behenic (<em>P</em> = 0.036) acids compared to survivors with a normal BMI. Childhood cancer survivors develop abnormalities in lipid metabolism, which may contribute to an earlier onset of metabolic syndrome. Additionally, overweight or obesity significantly exacerbates changes in lipid metabolism.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"136 ","pages":"Article 112799"},"PeriodicalIF":3.2,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143942993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of ultra-processed foods on human health: A comprehensive review of genomic instability and molecular mechanisms","authors":"Raquel D.S. Freitas Ph.D. ,&nbsp;Juliana da Silva Ph.D.","doi":"10.1016/j.nut.2025.112800","DOIUrl":"10.1016/j.nut.2025.112800","url":null,"abstract":"<div><div>In this review the nexus between genomic instability and human health is investigated, emphasizing the rising consumption of ultra-processed foods (UPFs). Introducing the NOVA food classification system, we explore the significant surge in UPF consumption over the past 3 decades and its correlation with heightened mortality rates. This exploration extends to the development of health issues such as obesity, cancer, type 2 diabetes, inflammatory bowel diseases, cardiovascular diseases, and depression. Existing evidence, including studies involving healthy adolescents and older adults, underscores a clear link between increased consumption of UPFs and heightened DNA damage. The primary objective of this review is to offer a comprehensive examination of the repercussions of elevated UPF consumption on human health. With a specific focus on unraveling the intricate relationship between these dietary choices and genomic instability, the review seeks to enhance our understanding. Through a targeted exploration of molecular pathways, the aim is to illuminate how dependence on UPFs may impact physical and mental well-being.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"137 ","pages":"Article 112800"},"PeriodicalIF":3.2,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144083911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal exposure to high-fat diet induces long-term mitochondrial alterations in the offspring heart","authors":"Mariapia Chindamo ,&nbsp;Hassib Chehade M.D. ,&nbsp;Anthony Sordet ,&nbsp;Gaël Humbert-Droz ,&nbsp;François Cachat M.D. ,&nbsp;Claire Mauduit Ph.D., M.C.U.-PH. ,&nbsp;Mohamed Benahmed M.D., Ph.D. ,&nbsp;Umberto Simeoni M.D. ,&nbsp;Benazir Siddeek Ph.D.","doi":"10.1016/j.nut.2025.112796","DOIUrl":"10.1016/j.nut.2025.112796","url":null,"abstract":"<div><h3>Objectives</h3><div>Heart disease is a leading cause of death worldwide, with its prevalence exacerbated by inadequate nutritional intake. Particularly concerning is the elevated risk induced by imbalanced nutrition during development, which can impact lifelong heart health. Recent research has underscored mitochondrial dysregulation as a pivotal mechanism driving the enduring consequences of nutritional excess. Building upon previous findings wherein a maternal high-fat diet (HFD) led to cardiac hypertrophy and fibrosis, our current study aimed to evaluate the impact of such a challenge on myocardial mitochondrial function.</div></div><div><h3>Methods</h3><div>Female rats were fed a chow diet or HFD during gestation and lactation. The hearts of male offspring were analyzed at adulthood. Mitochondrial DNA abundance was evaluated by quantitative polymerase chain reaction. Proteins involved in mitochondrial biogenesis, fusion, fission, damage to the electron transport chain, metabolism, cell death, proliferation, and inflammation were measured by western blot. Mitochondrial clearance was evaluated by the measurement of mitophagy markers on isolated mitochondria. Lipids were visualized by histologic approaches.</div></div><div><h3>Results</h3><div>We detected decreased cardiac mitochondrial fission factor and mitochondrial adenosine triphosphate synthase beta subunit and increased Parkin, pro-tumor necrosis factor alpha, and pro-interleukin 1 beta protein levels associated with decreased microtubule-associated protein 1A/1B light chain 3B levels in cardiac mitochondrial fraction, with a tendency for increased Oil Red O staining in the adult hearts of male offspring exposed to HFD.</div></div><div><h3>Conclusions</h3><div>Maternal exposure to HFD enhanced mitochondrial damage and impaired fission and clearance in offspring hearts at adulthood. These alterations were associated with altered expression of proteins involved in the mitochondrial electron transport chain coupled with a propensity for increased fatty acid accumulation and elevated proinflammatory markers.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"137 ","pages":"Article 112796"},"PeriodicalIF":3.2,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144107122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Handgrip strength and platelet-to-albumin ratio as joint prognostic indicator for patients with cancer cachexia","authors":"Saba Fida M.P.H., Ph.D. ,&nbsp;Hongxia Xu M.D., Ph.D. ,&nbsp;Min Weng M.D., Ph.D. ,&nbsp;Chunling Zhou M.D., Ph.D. ,&nbsp;Hu Ma M.D., Ph.D. ,&nbsp;Wei Li M.D., Ph.D. ,&nbsp;Jiuwei Cui M.D., Ph.D. ,&nbsp;Hanping Shi M.D., Ph.D. ,&nbsp;Chunhua Song M.D., Ph.D.","doi":"10.1016/j.nut.2025.112794","DOIUrl":"10.1016/j.nut.2025.112794","url":null,"abstract":"<div><h3>Background</h3><div>Handgrip strength (HGS) and platelet-to-albumin ratio (PAR) are established prognostic markers of cancer cachexia. This study evaluates the combined efficacy of HGS and PAR using a single index (HPA) for predicting survival outcomes in cancer patients with cachexia aged ≥18 years.</div></div><div><h3>Methods</h3><div>The multicenter Nutrition Status and Its Clinical Outcomes in Common Cancers study, conducted from July 2013 to April 2022, enrolled 5189 participants. Thresholds for HGS and PAR were determined using optimal stratification, leading to the development of HPA index. Prognostic accuracy was assessed using time-dependent receiver operating characteristic analysis, Kaplan–Meier survival curves, and Cox proportional hazards models.</div></div><div><h3>Results</h3><div>The cohort consisted of 3127 men and 2062 women, with a median follow-up of 36 months, and mean age of 58 years. Low HGS thresholds were 19 kg (female) and 31.9 kg (male), and high PAR cut-offs were 9.07 × 10⁹ (female) and 6.52 × 10⁹ (male). Both low HGS and high PAR levels were linked to increased mortality risk. The HPA index showed superior prognostic accuracy (C-index = 0.611; 95% confidence interval: 0.58–0.61; <em>P</em> &lt; 0.001) compared with HGS or PAR alone. Kaplan–Meier analysis indicated significantly reduced survival in patients with low HGS and high PAR.</div></div><div><h3>Conclusions</h3><div>The HPA index is a clinically significant prognostic tool for cancer cachexia, enhancing survival prediction and guiding patient management.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"136 ","pages":"Article 112794"},"PeriodicalIF":3.2,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143923873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}