Impact of ultra-processed foods on human health: A comprehensive review of genomic instability and molecular mechanisms

IF 3.2 3区医学 Q2 NUTRITION & DIETETICS

Nutrition Pub Date : 2025-04-10 DOI:10.1016/j.nut.2025.112800

Raquel D.S. Freitas Ph.D. , Juliana da Silva Ph.D.

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Abstract

In this review the nexus between genomic instability and human health is investigated, emphasizing the rising consumption of ultra-processed foods (UPFs). Introducing the NOVA food classification system, we explore the significant surge in UPF consumption over the past 3 decades and its correlation with heightened mortality rates. This exploration extends to the development of health issues such as obesity, cancer, type 2 diabetes, inflammatory bowel diseases, cardiovascular diseases, and depression. Existing evidence, including studies involving healthy adolescents and older adults, underscores a clear link between increased consumption of UPFs and heightened DNA damage. The primary objective of this review is to offer a comprehensive examination of the repercussions of elevated UPF consumption on human health. With a specific focus on unraveling the intricate relationship between these dietary choices and genomic instability, the review seeks to enhance our understanding. Through a targeted exploration of molecular pathways, the aim is to illuminate how dependence on UPFs may impact physical and mental well-being.

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超加工食品对人类健康的影响：基因组不稳定性和分子机制的综合综述

在这篇综述中，研究了基因组不稳定性与人类健康之间的关系，强调了超加工食品（upf）消费的增加。介绍NOVA食品分类系统，我们探讨了过去30年UPF消费的显著激增及其与死亡率升高的相关性。这种探索延伸到健康问题的发展，如肥胖、癌症、2型糖尿病、炎症性肠病、心血管疾病和抑郁症。现有证据，包括涉及健康青少年和老年人的研究，强调了upf消费增加与DNA损伤加剧之间的明显联系。本次审查的主要目的是全面审查UPF消费增加对人类健康的影响。这篇综述特别关注于揭示这些饮食选择和基因组不稳定性之间的复杂关系，旨在增强我们的理解。通过对分子途径的有针对性的探索，目的是阐明对upf的依赖如何影响身心健康。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutrition 医学-营养学

CiteScore

7.80

自引率

2.30%

发文量

300

审稿时长

60 days

期刊介绍： Nutrition has an open access mirror journal Nutrition: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. Founded by Michael M. Meguid in the early 1980''s, Nutrition presents advances in nutrition research and science, informs its readers on new and advancing technologies and data in clinical nutrition practice, encourages the application of outcomes research and meta-analyses to problems in patient-related nutrition; and seeks to help clarify and set the research, policy and practice agenda for nutrition science to enhance human well-being in the years ahead.