NPJ Primary Care Respiratory Medicine最新文献_第4页

Pharmaceutical treatment status of patients with COPD in the community based on medical Internet of Things: a real-world study. 基于医疗物联网的社区慢性阻塞性肺病患者药物治疗状况：一项真实世界研究。

IF 3.1 3区医学

NPJ Primary Care Respiratory Medicine Pub Date : 2024-05-10 DOI: 10.1038/s41533-024-00371-0

Peng Wu, Yi-Qun Jiang, Feng-Li Si, Huan-Ying Wang, Xiao-Bo Song, Chun-Feng Sheng, Xun Xu, Fan Li, Jing Zhang

{"title":"Pharmaceutical treatment status of patients with COPD in the community based on medical Internet of Things: a real-world study.","authors":"Peng Wu, Yi-Qun Jiang, Feng-Li Si, Huan-Ying Wang, Xiao-Bo Song, Chun-Feng Sheng, Xun Xu, Fan Li, Jing Zhang","doi":"10.1038/s41533-024-00371-0","DOIUrl":"10.1038/s41533-024-00371-0","url":null,"abstract":"This study aimed to investigate the real-world standardisation and adherence of medical treatment regimens in patients with chronic obstructive pulmonary disease (COPD) in the community for making future management strategy. The follow-up data and treatment information of patients with COPD, which were collected through the Management Information Center of COPD (MICCOPD) in 21 community health service centres in Songjiang District, a countryside region of Shanghai. Concordance between the pharmaceutical treatment plan and recommendation of 2017 Global Initiative for Chronic Obstructive Lung Disease (GOLD) report during the follow-up management period, as well as the medication adherence by patients,were analysed. Out of the 2044 patients diagnosed with COPD, 814 patients (39.8%) who had an initial record of medication use were found to meet the inclusion criteria. The most common medication regimens were long-acting beta-agonist plus inhaled corticosteroids (35.9%) and oral bronchodilators (41.9%). Among these 814 patients, 45.7%, 38.0%, 31.6% and 14.6% adhered to the treatment after 6, 12, 18 and 24 months of follow-up, respectively. The concordance rate with the regimens recommended by the 2017 GOLD guidelines was 35.5% at baseline, 35.5% at 6 months, 32.7% at 12 months, 35.4% at 18 months and 37% at 24 months. The compliance and guideline consistency rates of patients with COPD in the community under the management of general practitioners need to be improved. Enhancing general practitioner proficiency in the prevention and management of COPD and increasing patient awareness of the condition, are crucial standardising and improving adherence to initial and follow-up COPD treatments.","PeriodicalId":19470,"journal":{"name":"NPJ Primary Care Respiratory Medicine","volume":"34 1","pages":"10"},"PeriodicalIF":3.1,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11087570/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140904792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of C-reactive protein rapid testing and communication skills training on antibiotic prescribing for acute cough. A cluster factorial randomised controlled trial. C反应蛋白快速检测和沟通技巧培训对急性咳嗽抗生素处方的影响。分组随机对照试验。

IF 3.1 3区医学

NPJ Primary Care Respiratory Medicine Pub Date : 2024-05-09 DOI: 10.1038/s41533-024-00368-9

Carl Llor, Marta Trapero-Bertran, Antoni Sisó-Almirall, Ramon Monfà, Rosa Abellana, Ana García-Sangenís, Ana Moragas, Rosa Morros

{"title":"Effects of C-reactive protein rapid testing and communication skills training on antibiotic prescribing for acute cough. A cluster factorial randomised controlled trial.","authors":"Carl Llor, Marta Trapero-Bertran, Antoni Sisó-Almirall, Ramon Monfà, Rosa Abellana, Ana García-Sangenís, Ana Moragas, Rosa Morros","doi":"10.1038/s41533-024-00368-9","DOIUrl":"10.1038/s41533-024-00368-9","url":null,"abstract":"This cluster randomised clinical trial carried out in 20 primary care centres in Barcelona was aimed at assessing the effect of a continuous intervention focused on C-reactive protein (CRP) rapid testing and training in enhanced communication skills (ECS) on antibiotic consumption for adults with acute cough due to lower respiratory tract infection (LRTI). The interventions consisted of general practitioners and nurses' use of CRP point-of-care and training in ECS separately and combined, and usual care. The primary outcomes were antibiotic consumption and variation of the quality-adjusted life years during a 6-week follow-up. The difference in the overall antibiotic prescribing between the winter seasons before and after the intervention was calculated. The sample size calculated could not be reached due to the COVID-19 outbreak. A total of 233 patients were recruited. Compared to the usual care group (56.7%) antibiotic consumption among patients assigned to professionals in the ECS group was significantly lower (33.9%, adjusted odds ratio [aOR] 0.38, 95% CI 0.15-0.94, p = 0.037), whereas patients assigned to CRP consumed 43.8% of antibiotics (aOR 0.70, 95% CI 0.29-1.68, p = 0.429) and 38.4% in the combined intervention group (aOR 0.45, 95% CI, 0.17-1.21; p = 0.112). The overall antibiotic prescribing rates in the centres receiving training were lower after the intervention compared to those assigned to usual care, with significant reductions in β-lactam rates. Patient recovery was similar in all groups. Despite the limited power due to the low number of patients included, we observed that continuous training achieved reductions in antibiotic consumption.","PeriodicalId":19470,"journal":{"name":"NPJ Primary Care Respiratory Medicine","volume":"34 1","pages":"9"},"PeriodicalIF":3.1,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11081949/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140899152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Measuring burden of disease in both asthma and COPD by merging the ACQ and CCQ: less is more? 通过合并 ACQ 和 CCQ 测量哮喘和慢性阻塞性肺病的疾病负担：少即是多？

IF 3.1 3区医学

NPJ Primary Care Respiratory Medicine Pub Date : 2024-05-03 DOI: 10.1038/s41533-024-00364-z

Liz J. A. Cuperus, Cathelijne M. van Zelst, Huib A. M. Kerstjens, Rudi W. Hendriks, Maureen P. M. H. Rutten-van Molken, Jacqueline B. Muilwijk-Kroes, Gert-Jan Braunstahl, Johannes C. C. M. in ’t Veen

{"title":"Measuring burden of disease in both asthma and COPD by merging the ACQ and CCQ: less is more?","authors":"Liz J. A. Cuperus, Cathelijne M. van Zelst, Huib A. M. Kerstjens, Rudi W. Hendriks, Maureen P. M. H. Rutten-van Molken, Jacqueline B. Muilwijk-Kroes, Gert-Jan Braunstahl, Johannes C. C. M. in ’t Veen","doi":"10.1038/s41533-024-00364-z","DOIUrl":"https://doi.org/10.1038/s41533-024-00364-z","url":null,"abstract":"Symptoms of asthma and COPD often overlap, and both diseases can co-exist in one patient. The asthma control questionnaire (ACQ) and clinical COPD questionnaire (CCQ) were developed to assess disease burden in respectively asthma or COPD. This study explores the possibility of creating a new questionnaire to assess disease burden in all obstructive lung diseases by integrating and reducing questions of the ACQ and CCQ. Data of patients with asthma, COPD and asthma-COPD overlap (ACO) were collected from a primary and secondary care center. Patients completed ACQ and CCQ on the same day. Linear regression tested correlations. Principal Component Analysis (PCA) was used for item reduction. The secondary cohort with asthma and COPD patients was used for initial question selection (development cohort). These results were reproduced in the primary care cohort and secondary cohort of patients with ACO. The development cohort comprised 252 patients with asthma and 96 with COPD. Correlation between ACQ and CCQ in asthma was R = 0.82, and in COPD R = 0.83. PCA determined a selection of 9 questions. Reproduction in primary care data (asthma n = 1110, COPD n = 1041, ACO = 355) and secondary care data of ACO patients (n = 53) resulted in similar correlations and PCA-derived selection of questions. In conclusion, PCA determined a selection of nine questions of the ACQ and CCQ: working title ‘the Obstructive Lung Disease Questionnaire’. These results suggest that this pragmatic set of questions might be sufficient to assess disease burden in obstructive lung disease in both primary as secondary care.","PeriodicalId":19470,"journal":{"name":"NPJ Primary Care Respiratory Medicine","volume":"106 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140841363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mixed-methods evaluation of an enhanced asthma biologics clinical pathway in the West Midlands UK 英国西米德兰兹郡哮喘生物制剂临床路径的混合方法评估

IF 3.1 3区医学

NPJ Primary Care Respiratory Medicine Pub Date : 2024-05-01 DOI: 10.1038/s41533-024-00365-y

Sarah Damery, Janet Jones, Elfatih Idris, Angela Cooper, Holly Minshall, Chris Clowes, Kate Jolly

{"title":"Mixed-methods evaluation of an enhanced asthma biologics clinical pathway in the West Midlands UK","authors":"Sarah Damery, Janet Jones, Elfatih Idris, Angela Cooper, Holly Minshall, Chris Clowes, Kate Jolly","doi":"10.1038/s41533-024-00365-y","DOIUrl":"https://doi.org/10.1038/s41533-024-00365-y","url":null,"abstract":"Biologic treatments can alleviate severe asthma symptoms and reduce health service use. However, service capacity limits and low referral rates from primary care indicate unmet patient need. We report a mixed-methods evaluation of an enhanced severe asthma pathway implemented in Staffordshire and Stoke-on-Trent, UK which aimed to optimise primary care referrals through training/education, and increased capacity in specialist clinics. Quantitative analysis assessed patient wait times between pathway stages, prescribing changes, exacerbations, hospital admissions and asthma control. Interviews with 12 stakeholders evaluated perceptions of the enhanced pathway across settings. In 12 months, 564 patients from 28 general practices were reviewed for biologics eligibility, of whom 125 (22.2%) were referred for specialist assessment. Wait times were significantly lower under the enhanced pathway when compared against historic patients following the standard pathway, and reduced overall from a mean of 76.4 to 26.7 weeks between referral and biologics initiation (p < 0.001). Patients commencing biologics (n = 46) showed significantly reduced reliever inhaler prescribing rates (p = 0.037), 60% lower oral steroid use (p < 0.001), significantly reduced exacerbation rates (p < 0.001) and fewer hospital admissions (p < 0.001) compared with the 12 months pre-treatment. Mean asthma control scores reduced from 3.13 pre-initiation to 1.89 post-initiation (p < 0.001) – a clinically significant improvement. Interviewees viewed the enhanced pathway positively, although ongoing issues related to difficulties engaging primary care amid concerns around increased workloads and pathway capacity. The large number of referrals generated from a comparatively small number of general practices confirms substantial unmet need that an enhanced severe asthma pathway could help address if implemented routinely.","PeriodicalId":19470,"journal":{"name":"NPJ Primary Care Respiratory Medicine","volume":"13 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140841103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reducing short-acting beta-agonist use in asthma: Impact of national incentives on prescribing practices in England and the findings from SENTINEL Plus early adopter sites 减少哮喘患者使用短效β-激动剂：国家激励措施对英格兰处方实践的影响以及 SENTINEL Plus 早期采用者的研究结果

IF 3.1 3区医学

NPJ Primary Care Respiratory Medicine Pub Date : 2024-04-29 DOI: 10.1038/s41533-024-00363-0

M. G. Crooks, H. Cummings, A. H. Morice, D. Sykes, S. Brooks, A. Jackson, Y. Xu

{"title":"Reducing short-acting beta-agonist use in asthma: Impact of national incentives on prescribing practices in England and the findings from SENTINEL Plus early adopter sites","authors":"M. G. Crooks, H. Cummings, A. H. Morice, D. Sykes, S. Brooks, A. Jackson, Y. Xu","doi":"10.1038/s41533-024-00363-0","DOIUrl":"https://doi.org/10.1038/s41533-024-00363-0","url":null,"abstract":"Short-acting beta-agonist (SABA) over-use in asthma is harmful for patients and the environment. The Investment and Impact Fund (IIF) 2022/2023 financially rewarded English primary care networks that achieved specific targets, including reducing SABA over-use (RESP-02) and lowering the mean carbon footprint per salbutamol inhaler prescribed (ES-02). SENTINEL Plus is a co-designed quality improvement package that aims to improve asthma outcomes and reduce asthma’s environmental impact by addressing SABA over-use. We investigated the impact of (i) the IIF incentives and (ii) SENTINEL Plus implementation on asthma prescribing. Using Openprescribing.net data, we demonstrate that IIF 2022-2023 had no significant impact on the total number of SABA prescribed in England (25,927,252 during 12-months pre- and 25,885,213 12-months post-IIF; 0.16% decrease; p=NS), but lower carbon footprint SABA inhaler use increased (Salamol™ prescribing increased from 5.1% to 19% of SABA prescriptions, p < 0.01). In contrast, SENTINEL Plus sites significantly reduced SABA prescribing post-implementation (5.43% decrease, p < 0.05).","PeriodicalId":19470,"journal":{"name":"NPJ Primary Care Respiratory Medicine","volume":"29 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140809552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The journey of lung cancer patients from symptoms to diagnosis in Greece. A mixed methods approach 希腊肺癌患者从症状到诊断的过程。混合方法

IF 3.1 3区医学

NPJ Primary Care Respiratory Medicine Pub Date : 2024-04-29 DOI: 10.1038/s41533-024-00359-w

Ioanna Tsiligianni, Antonios Christodoulakis, Alexia Monastirioti, Dimitrios Mavroudis, Sofia Agelaki

{"title":"The journey of lung cancer patients from symptoms to diagnosis in Greece. A mixed methods approach","authors":"Ioanna Tsiligianni, Antonios Christodoulakis, Alexia Monastirioti, Dimitrios Mavroudis, Sofia Agelaki","doi":"10.1038/s41533-024-00359-w","DOIUrl":"https://doi.org/10.1038/s41533-024-00359-w","url":null,"abstract":"The early diagnosis of lung cancer improves the probability of successful treatment. However, patients and physicians face several difficulties that can considerably delay the diagnostic process. A mixed-methods study that would follow the patient’s journey throughout the diagnostic process could alleviate these difficulties. This study aimed to (a) track the patients’ journey from the onset of symptoms until diagnosis and, (b) explore the patients’ perspective of the journey until diagnosis, on the largest island of Greece. A convergent mixed-methods study was conducted with 94 patients with lung cancer. Patients completed a self-report questionnaire and were interviewed about their symptoms and journey through the healthcare system before their diagnosis. Our findings revealed several problems and delays in the diagnostic process. Both quantitative and qualitative data showed that patients did not recognize their symptoms and sought medical advice in time because they overlooked or attributed their symptoms to ‘simpler’/‘more common’ causes. Furthermore, most patients were diagnosed 1–3 months after their first visit to a physician for their symptoms. Qualitative data analysis revealed three broad categories of problems that delayed diagnosis: (1) physician missteps, (2) administrative problems, and (3) the effect of the Covid-19 pandemic. This study found that major issues and delays prolong the diagnostic process for lung cancer. Therefore, optimization of diagnostic processes at each level of healthcare and interspecialty cooperation programs are needed. Furthermore, population-based interventions and patient education can help lung cancer patients be diagnosed early and improve their quality of life and disease outcomes.","PeriodicalId":19470,"journal":{"name":"NPJ Primary Care Respiratory Medicine","volume":"2016 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140809822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How to make Asthma Right Care ‘easy’ in primary care: learnings from the 2023 Asthma Right Care Summit 如何让 "哮喘正确护理 "在初级保健中变得 "简单"：从 2023 年 "哮喘正确护理 "峰会中学到的知识

IF 3.1 3区医学

NPJ Primary Care Respiratory Medicine Pub Date : 2024-04-26 DOI: 10.1038/s41533-024-00366-x

Siân Williams, J. Correia de Sousa, Ee Ming Khoo, Habib Ghedira, Vincent Mak, M. M. Martínez Vázquez, Cláudia Vicente, D. Attar-Zadeh

引用次数: 0

The relationship between prescription rates of oral corticosteroids for respiratory diseases and deprivation in England 英格兰呼吸系统疾病口服皮质类固醇处方率与贫困之间的关系

IF 3.1 3区医学

NPJ Primary Care Respiratory Medicine Pub Date : 2024-04-25 DOI: 10.1038/s41533-024-00362-1

Erin Barker, Jessica Pocock, J. Moss, Nick Hex, Jordan Rankin, Richard Hudson

引用次数: 0

Documentation of comorbidities, lifestyle factors, and asthma management during primary care scheduled asthma contacts. 记录合并症、生活方式因素以及在初级保健计划的哮喘接触中的哮喘管理情况。

IF 3.1 3区医学

NPJ Primary Care Respiratory Medicine Pub Date : 2024-03-09 DOI: 10.1038/s41533-024-00360-3

Jaana Takala, Iida Vähätalo, Leena E Tuomisto, Onni Niemelä, Pinja Ilmarinen, Hannu Kankaanranta

{"title":"Documentation of comorbidities, lifestyle factors, and asthma management during primary care scheduled asthma contacts.","authors":"Jaana Takala, Iida Vähätalo, Leena E Tuomisto, Onni Niemelä, Pinja Ilmarinen, Hannu Kankaanranta","doi":"10.1038/s41533-024-00360-3","DOIUrl":"10.1038/s41533-024-00360-3","url":null,"abstract":"Systematically assessing asthma during follow-up contacts is important to accomplish comprehensive treatment. No previous long-term studies exist on how comorbidities, lifestyle factors, and asthma management details are documented in scheduled asthma contacts in primary health care (PHC). We showed comorbidities and lifestyle factors were poorly documented in PHC in this real-life, 12-year, follow-up study. Documented information on rhinitis was found in 8.9% and BMI, overweight, or obesity in ≤1.5% of the 542 scheduled asthma contacts. Of the 145 patients with scheduled asthma contacts, 6.9% had undergone revision of their inhalation technique; 16.6% had documentation of their asthma action plan. Screening of respiratory symptoms was recorded in 79% but nasal symptoms in only 15.5% of contacts. Lifestyle guidance interventions were found in <1% of contacts. These results, based on documented patient data, indicate a need exists to further improve the assessment and guidance of asthma patients in PHC.","PeriodicalId":19470,"journal":{"name":"NPJ Primary Care Respiratory Medicine","volume":"34 1","pages":"2"},"PeriodicalIF":3.1,"publicationDate":"2024-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10925028/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140068646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Medication adherence halves COPD patients' hospitalization risk - evidence from Swiss health insurance data. 坚持用药可将慢性阻塞性肺病患者的住院风险减半--来自瑞士医疗保险数据的证据。

IF 3.1 3区医学

NPJ Primary Care Respiratory Medicine Pub Date : 2024-03-07 DOI: 10.1038/s41533-024-00361-2

Anja Y Bischof, Johannes Cordier, Justus Vogel, Alexander Geissler

{"title":"Medication adherence halves COPD patients' hospitalization risk - evidence from Swiss health insurance data.","authors":"Anja Y Bischof, Johannes Cordier, Justus Vogel, Alexander Geissler","doi":"10.1038/s41533-024-00361-2","DOIUrl":"10.1038/s41533-024-00361-2","url":null,"abstract":"Medication adherence is vital for patients suffering from Chronic Obstructive Pulmonary Disease (COPD) to mitigate long-term consequences. The impact of poor medication adherence on inferior outcomes like exacerbations leading to hospital admissions is yet to be studied using real-world data. Using Swiss claims data from 2015-2020, we group patients into five categories according to their medication possession ratio. By employing a logistic regression, we quantify each category's average treatment effect of the medication possession ratio on hospitalized exacerbations. 13,557 COPD patients are included in the analysis. Patients with high medication adherence (daily medication reserve of 80% to 100%) are 51% less likely to incur exacerbation following a hospital stay than patients with the lowest medication adherence (daily medication reserve of 0% to 20%). The study shows that medication adherence varies strongly among Swiss COPD patients. Furthermore, high medication adherence immensely decreases the risk of hospitalized exacerbations.","PeriodicalId":19470,"journal":{"name":"NPJ Primary Care Respiratory Medicine","volume":"34 1","pages":"1"},"PeriodicalIF":3.1,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10920735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140060059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0