NPJ Primary Care Respiratory Medicine最新文献

{"title":"Risk factors of post-COVID-19 symptoms, a cross-sectional study in patients with asthma and chronic obstructive lung disease.","authors":"Agnes Andreason, Björn Ställberg, Karin Lisspers, Anna Nager, Hanna Sandelowsky, Josefin Sundh, Gabriella Eliason, Scott Montgomery, Christer Janson, Marta A Kisiel","doi":"10.1038/s41533-026-00570-x","DOIUrl":"10.1038/s41533-026-00570-x","url":null,"abstract":"<p><p>Post-COVID-19 symptoms are common following COVID-19, but risk factors of persistent symptoms in patients with asthma and chronic obstructive lung disease (COPD) remain unclear. We aimed to assess the frequency and risk factors of post-COVID-19 symptoms in patients with asthma and COPD. In this cross-sectional study, we used data from the Swedish PRAXIS study collected in 2022. The cohort included randomly selected adult patients with a diagnosis of asthma or COPD in medical records from central Sweden's primary and secondary care. Participants completed a comprehensive questionnaire, and their responses were analysed. We used logistic regression and adjusted for age and lung disease diagnoses. Among 494 patients with confirmed COVID-19, 59% (289/494) reported post-COVID-19 symptoms. Risk factors for post-COVID-19 symptoms included severe acute infection (adjusted odds ratio aOR: 8.91, 95% confidence interval [CI]: 3.49-22.8), higher age (aOR:1.25, 95% CI: 1.09-1.45), female sex (aOR: 1.52, 95% CI: 1.04-2.21), and obesity [BMI ≥ 30] (aOR: 2.24, 95% CI: 1.44-3.47)). Anxiety/depression (aOR:1.79, 95% CI: 1.13-2.80) and chronic pain (aOR: 3.61, 95% CI: 1.95-6.69) were also significant risk factors. Patients with asthma or COPD had a high prevalence of post-COVID-19 symptoms compared to other studies. Several demographic and clinical factors were associated with post-COVID-19 symptoms, which could help identify patients at increased risk.</p>","PeriodicalId":19470,"journal":{"name":"NPJ Primary Care Respiratory Medicine","volume":"36 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13620127/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149075404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using AI to determine optimal cost-effective diagnostic pathways for chronic breathlessness.","authors":"Max Olsson, Rafsan Ahmed, Joakim Ekstrand, Anders Blomberg, Tomas Jernberg, Mats Börjesson, Rachael A Evans, Andrei Malinovschi, Jacob Sandberg, Magnus Sköld, Per Wollmer, Carl Johan Östgren, Gunnar Engström, Anders J Björkelund, Magnus Ekström","doi":"10.1038/s41533-026-00548-9","DOIUrl":"https://doi.org/10.1038/s41533-026-00548-9","url":null,"abstract":"<p><p>Breathlessness is a common symptom in clinical practice, yet evidence for cost-effective strategies to diagnose the underlying health conditions causing breathlessness remains limited. Using Swedish population data with individuals with moderate to severe breathlessness, we developed an artificial intelligence (AI) reinforcement learning model to identify optimal, low-cost diagnostic pathways for breathlessness tailored to subgroups based on sex and smoking exposure. Sixteen clinically relevant conditions were defined, along with their diagnostic tests and standard healthcare costs. The AI-based approach successfully produced efficient and low-cost diagnostic pathways for breathlessness with high diagnostic yield. The optimal sequences were overall similar between the subgroups. For all participant subgroups, the AI-derived pathways initially identified (or order of effectiveness in relation to costs) clinical evaluations of body mass index, anxiety and depression, physical activity levels, and spirometry. Subsequent steps included diffusing capacity measurements, chest computer tomography, and hemoglobin assessment. Overall, investigations of the lungs were prioritized ahead of investigations of the heart. This strategy has the potential to streamline the evaluation of breathlessness, reduce unnecessary testing, lead to an earlier diagnosis at lower cost, and support more targeted clinical management.</p>","PeriodicalId":19470,"journal":{"name":"NPJ Primary Care Respiratory Medicine","volume":"36 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13473488/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148761292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vaccination disparities and structural barriers among current smokers and adults with COPD: implications for comprehensive respiratory prevention.","authors":"Ying Zhou, Yang Liu, Yue Ning","doi":"10.1038/s41533-026-00540-3","DOIUrl":"https://doi.org/10.1038/s41533-026-00540-3","url":null,"abstract":"<p><p>Comprehensive respiratory health management for populations with elevated respiratory and lung cancer-related risk remains a guideline-recommended component of comprehensive respiratory prevention, yet uptake has not been systematically characterized. Using vaccination as a sentinel marker of healthcare engagement, we examined 2020-2024 BRFSS data on influenza and pneumococcal vaccination among U.S. adults classified as healthy controls, current smokers without COPD, individuals with COPD who were former or never smokers, and current smokers with COPD. Adults with both current smoking and COPD showed a substantial prevention gap. Despite high clinical vulnerability, this Dual Risk group had lower vaccination uptake than the COPD-only group, particularly among adults aged 45-64 years. In multivariable models, current smoking was associated with attenuation of the expected disease-prompting effect observed among non-smoking individuals with COPD. Mediation analysis suggested that healthcare access barriers, especially absence of a personal healthcare provider and lack of routine checkups, explained much of the vaccination disparity, whereas broader socioeconomic indicators explained less. Although vaccination uptake is not a direct measure of low-dose computed tomography screening, it may serve as a sentinel marker of primary care engagement and missed opportunities for respiratory prevention. Findings should be interpreted cautiously given the cross-sectional design, potential age-related confounding for pneumococcal vaccination under pre-2024 CDC recommendations, and the broader BRFSS smoking definition compared with clinical screening criteria. Integrating vaccination assessment, smoking cessation services, and appropriate screening referral through primary care, pharmacies, and cessation clinics may reduce missed opportunities among high-risk adults.</p>","PeriodicalId":19470,"journal":{"name":"NPJ Primary Care Respiratory Medicine","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148456445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health literacy-sensitive self-management interventions for chronic obstructive pulmonary disease: a systematic review and meta-analysis.","authors":"Changfu Chen, Miao Zhan, Hongying Zhang","doi":"10.1038/s41533-026-00539-w","DOIUrl":"10.1038/s41533-026-00539-w","url":null,"abstract":"<p><p>Chronic obstructive pulmonary disease (COPD) requires sustained self-management, and health literacy may play an important role in patients' ability to understand, implement, and maintain disease-management behaviors. However, the effectiveness of self-management interventions incorporating health literacy-sensitive components in COPD remains unclear. We conducted a systematic review and meta-analysis of randomized controlled trials evaluating health literacy-sensitive self-management interventions for adults with COPD. Health literacy-sensitive self-management interventions were defined as self-management programs incorporating explicitly identifiable strategies intended to reduce literacy-related barriers or to support patients in obtaining, understanding, appraising, or applying COPD-related health information in daily self-management. Nine databases were searched from inception to August 30, 2025. Thirty-one randomized controlled trials involving 4759 participants were included. Outcomes included 6 min walk distance (6MWD), forced expiratory volume in 1 s as a percentage of predicted value (FEV₁% predicted), St George's Respiratory Questionnaire (SGRQ), modified Medical Research Council (mMRC) dyspnea score, COPD Assessment Test (CAT), and self-management-related outcomes. Risk of bias was assessed using the Cochrane Risk of Bias tool, and pooled effects were calculated using fixed- or random-effects models according to heterogeneity. Compared with usual care, self-management interventions with health literacy-sensitive components were associated with improvements in 6MWD (MD = 44.81 m, 95% CI 17.48-72.14; p = 0.001), FEV₁% predicted (MD = 7.43, 95% CI 6.31-8.55; p < 0.00001), SGRQ total score (MD = -6.80, 95% CI -9.80--3.80; p < 0.00001), mMRC score (MD = -0.40, 95% CI -0.61--0.19; p = 0.0002), CAT score (MD = -3.78, 95% CI -5.49--2.07; p < 0.0001), and self-management-related outcomes (SMD = 1.50, 95% CI 1.34-1.67; p < 0.00001). Substantial heterogeneity was observed for several outcomes, particularly 6MWD, SGRQ, mMRC, CAT, and self-management-related outcomes. Health literacy-sensitive self-management interventions were associated with improvements in exercise capacity, pulmonary function, symptom burden, dyspnea, health-related quality of life, and self-management-related outcomes in patients with COPD. However, the evidence should be interpreted with caution because eligible interventions were defined by the presence of explicitly identifiable health literacy-sensitive strategies embedded within self-management programs, rather than by isolated health-literacy enhancement alone, and substantial heterogeneity and variable methodological quality were present across studies. More rigorously designed and standardized trials are needed to clarify the specific contribution of health literacy-sensitive strategies and their long-term effectiveness in COPD care.</p>","PeriodicalId":19470,"journal":{"name":"NPJ Primary Care Respiratory Medicine","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13369493/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148437349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and risk factors of small airway dysfunction among rural residents in Western China: a real-world cross-sectional study.","authors":"Lu Dai, Konglong Shen, Qingqing Su, Jiang Yu, Lifen Li, Haitong Zhao, Xi Shen, Xuan Zhang, Fengming Luo","doi":"10.1038/s41533-026-00538-x","DOIUrl":"https://doi.org/10.1038/s41533-026-00538-x","url":null,"abstract":"<p><p>Small airway dysfunction (SAD) is an early precursor to chronic obstructive pulmonary disease (COPD) and asthma but underdiagnosed, especially in rural settings. We aimed to estimate SAD prevalence and identify its risk factors among adults ≥ 40 years in rural western China. A cross-sectional survey was conducted among 11,398 rural residents aged ≥ 40 years in Mianyang, Sichuan, China. SAD was defined spirometrically as at least two of three indices below 65% of predicted values, including maximal mid-expiratory flow, forced expiratory flow at 50 and 75% of forced vital capacity. Multivariable logistic regression was used. Model 1 adjusted for age and sex; Model 2 additionally adjusted for education, smoking, household fuel use, residential dust exposure, and so forth. SAD prevalence was 49.21%. Higher risk was observed in older adults (≥60 years) and women (Model 2 OR = 1.74 [1.54-1.96]). Biomass fuel exposure (Model 1 OR = 1.29 [1.15-1.45]; Model 2 OR = 1.23 [1.07-1.41]) and coal fuel exposure (Model 1 OR = 1.23 [1.14-1.32]) were associated with SAD. Higher education and low residential dust exposure were protective. Subgroup analysis performed that in women, SAD prevalence increased with biomass fuel and secondhand smoke exposure. SAD is highly prevalent among rural adults aged ≥ 40 years in western China and is linked to multiple modifiable factors, particularly household solid fuel use. These findings suggest that routine pulmonary function screening in high-risk populations and targeted interventions, such as cleaner household energy, improved ventilation, and stratified health education, may contribute to early prevention of COPD and asthma.</p>","PeriodicalId":19470,"journal":{"name":"NPJ Primary Care Respiratory Medicine","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148422895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cost-effectiveness of targeted COPD case-finding with the PUMA questionnaire followed by spirometry among ever-smokers in Singapore.","authors":"Irene Li Peng Ooi, Vicky Mengqi Qin, Eng Sing Lee, Kenneth Tan, Geak Poh Tan, Jo-Anne Manski-Nankervis, Akshar Saxena","doi":"10.1038/s41533-026-00533-2","DOIUrl":"https://doi.org/10.1038/s41533-026-00533-2","url":null,"abstract":"<p><strong>Background: </strong>Chronic obstructive pulmonary disease (COPD) is frequently undiagnosed among ever-smokers. We evaluated the cost-effectiveness of targeted COPD case-finding using the PUMA questionnaire followed by spirometry among ever-smokers aged 50 years and older in Singapore.</p><p><strong>Methods: </strong>A cohort Markov model compared two strategies: PUMA-based case-finding (PUMA score ≥4) followed by spirometry versus no case-finding, over a lifetime horizon from the healthcare payer perspective, with 3% annual discounting. A willingness-to-pay threshold of SGD75,000/QALY was applied.</p><p><strong>Results: </strong>Case-finding yielded an incremental cost of SGD 2,475 and an incremental gain of 0.0339 QALYs per person (ICER: SGD 73,065/QALY). Probabilistic sensitivity analysis indicated a 71.1% probability of being cost-effective at SGD 75,000/QALY. The ICER was most sensitive to the odds ratio of exacerbation for individuals with mild and moderate COPD treated with Long-Acting Muscarinic Antagonist (LAMA), and the severity distribution of undiagnosed COPD.</p><p><strong>Conclusions: </strong>PUMA-based targeted COPD case-finding followed by spirometry is likely to be cost-effective at Singapore's willingness-to-pay threshold.</p>","PeriodicalId":19470,"journal":{"name":"NPJ Primary Care Respiratory Medicine","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148412355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic adequacy of COPD in primary care: a population-based analysis of spirometry use and risk-factor documentation.","authors":"António Pedro Gonçalves Rodrigues da Fonte, Inês Gonçalo Domingues, Benvinda Alexandra Martins da Costa Barbosa, Carina Alexandra Peixoto Ferreira, Thys van der Mollen, António Jaime Botelho Correia de Sousa","doi":"10.1038/s41533-026-00525-2","DOIUrl":"https://doi.org/10.1038/s41533-026-00525-2","url":null,"abstract":"<p><strong>Background: </strong>Diagnosing COPD in primary care remains challenging, with significant international evidence of underdiagnosis, misdiagnosis and miscoding. How reliably COPD diagnoses in real-world practice reflect objective diagnostic criteria is less well understood.</p><p><strong>Aim: </strong>To evaluate the compatibility between recorded COPD diagnoses and key diagnostic criteria - spirometry and risk-factor documentation - and to identify patient and contextual factors associated with diagnostic adequacy.</p><p><strong>Methods: </strong>A population-based, cross-sectional study including all patients with a recorded diagnosis of COPD across a large Portuguese primary care cluster (17 Family Health Units; 182,947 patients). Electronic Health Records data were extracted for demographics, comorbidities, symptoms, exposures, spirometry and clinical follow-up. Spirometry and risk-factor records were independently classified according to their compatibility with a diagnosis of COPD (compatible, uncertain or not compatible) and combined to derive diagnostic-certainty categories. Associations were analysed using non-parametric tests and multinomial logistic regression.</p><p><strong>Results: </strong>Among 1817 included patients, only 3.63% had both spirometry and exposure records fully compatible with COPD at diagnosis; 24.05% had incompatible records. Using the most recent spirometry, compatibility improved only marginally (4.4%), while incompatible cases remained high (21.57%). Spirometry was absent or non-confirmatory in nearly 80% of patients, and smoking or other exposures documentation was missing or incomplete in almost 50%. Diagnostic incompatibility was strongly associated with older age, female sex, diagnosis made outside primary care, multimorbidity, and especially psychological comorbidities (OR 11.6; 95% CI 7.7-17.4). Asthma was the only respiratory comorbidity significantly associated with incompatible diagnoses. Records of symptoms, exacerbations and GOLD classification were infrequently documented.</p><p><strong>Conclusions: </strong>COPD diagnoses recorded in routine primary care frequently lack spirometric confirmation and adequate documentation of risk factors, resulting in high rates of incompatible diagnoses. Diagnostic adequacy reflects demographic, social and clinical determinants, revealing important inequities. These findings highlight an urgent need to strengthen diagnostic pathways through systematic use of spirometry, structured recording of risk factors and symptoms, and enhanced electronic health records documentation. Improving these core elements is essential to ensure accurate, consistent and equitable COPD diagnosis in primary care.</p>","PeriodicalId":19470,"journal":{"name":"NPJ Primary Care Respiratory Medicine","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148397264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital inhaler data in routine asthma care: defining a minimal dataset for clinical decision support (AURORA): a modified delphi study.","authors":"Mechteld B R Wiertz, Amber A Eikholt, Anneke Ten Brinke, Els J M Weersink, Irene van der Weerdt, Johannes C C M In 't Veen, Kornelis W Patberg, Martijn Goosens, Niels H Chavannes, Sandra Been-Buck, Titia Klemmeier, Huib A M Kerstjens, Job F M van Boven","doi":"10.1038/s41533-026-00536-z","DOIUrl":"https://doi.org/10.1038/s41533-026-00536-z","url":null,"abstract":"<p><p>Digital inhalers can assess and support medication adherence and inhalation technique and may predict exacerbations, yet real-world evidence on their use, implementation, and clinical impact remains limited. To date, no standardized registry exists to systematically capture digital inhaler use across the full spectrum of asthma severity. To reach an expert consensus on a minimal and feasible dataset for a registry (AURORA) of asthma patients using digital inhalers. A three-round modified Delphi process was conducted involving 15 Dutch experts in asthma care, medication adherence, digital health, regulatory science, and healthcare policy. In Rounds 1 and 2, candidate variables were evaluated via an online Delphi platform, with predefined consensus thresholds for inclusion and exclusion. Patient perspectives were incorporated through structured interviews. Final consensus was achieved during an online meeting in Round 3 (≥66% agreement required). Of 92 variables considered, 18 were classified as core and 45 as optional. Core variables covered key domains, including patient demographics, asthma control, medication type, digital inhaler characteristics, medication adherence, inhaler technique, and patient satisfaction. Optional variables provide flexibility to support implementation across different healthcare settings. This modified Delphi study established a consensus-based national registry framework specifically focused on digital inhaler use in asthma. The AURORA registry provides a standardized and feasible foundation for generating real-world evidence to support future research, personalized treatment decisions, and the optimization of escalation strategies in routine asthma care.</p>","PeriodicalId":19470,"journal":{"name":"NPJ Primary Care Respiratory Medicine","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148382562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physicians' perspectives on shared decision-making in antibiotic prescriptions for acute respiratory tract infections at a primary healthcare centre in ethiopia: a qualitative study.","authors":"Gashaw Enbiyale Kasse, Suzanne M Cosh, Judy Humphries, Shahidul Islam","doi":"10.1038/s41533-026-00534-1","DOIUrl":"10.1038/s41533-026-00534-1","url":null,"abstract":"<p><p>Shared decision-making (SDM) is a collaborative process in which healthcare providers and patients work together to make informed healthcare choices, significantly reducing unnecessary antimicrobial prescriptions by aligning treatment decisions with both clinical evidence and patient values. There is limited qualitative research exploring physicians' perspectives on its implementation in the study area. This study aims to explore physicians' perspectives and experience of SDM in the management of Acute Respiratory Tract Infections (ARTIs) at public primary healthcare centres. Purposive sampling was applied to recruit physicians from selected primary healthcare centres in the Amhara region of Ethiopia. The sample size was determined using the concept of data saturation. The data were collected through semi-structured interviews and analysed using thematic analysis with the assistance of NVivo software (version 14). Twenty physicians were interviewed, and four main themes were identified: (1) awareness and understanding of SDM; (2) perceived value of SDM; (3) barriers to implementing SDM; (4) facilitators to enhance SDM implementation. The study found that, despite its recognised benefits, SDM is not yet a routine practice in primary healthcare centres in the study area due to identified barriers. Addressing these challenges and implementing the solutions suggested by participants will be essential to realise the full benefits of SDM and strengthen antimicrobial resistance mitigation efforts.</p>","PeriodicalId":19470,"journal":{"name":"NPJ Primary Care Respiratory Medicine","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13662199/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148331610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Objective dyspnea measurement in real time using a forehead wearable and artificial intelligence.","authors":"Sabrina Meng, Alexandru Bogdan, Alireza Akhbardeh, Hersh Sagreiya","doi":"10.1038/s41533-026-00529-y","DOIUrl":"10.1038/s41533-026-00529-y","url":null,"abstract":"<p><p>Dyspnea is a complex symptom measured using subjective patient-reported ratings. Continuous, automated dyspnea measurements are needed, especially in critical care and trauma settings with impaired patient communication. We prospectively enrolled 54 pulmonary rehabilitation subjects. Participants completed two treadmill walking trials, during which dyspnea measurements were collected at one-minute intervals automatically using physiologic sensors and patient-reported ratings of perceived breathlessness and exertion (RPB and RPE). The sensor data were used to train machine learning models using either 19 or 7 features to generate an objective dyspnea score (ODS). Classification performance was assessed on a held-out test set, compared against patient-reported RPB and RPE. The model trained on 7 features performed best, resulting in a correlation between predicted and actual scores (percent accuracy) of 0.84 (78.7%) for RPE and 0.86 (83.6%) for RPB. Our system incorporating ODS accurately predicts patients' subjective dyspnea scores and is promising for automated, real-time dyspnea measurement.</p>","PeriodicalId":19470,"journal":{"name":"NPJ Primary Care Respiratory Medicine","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13655054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148308827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}