NPJ Primary Care Respiratory Medicine最新文献_第10页

A systematic review of the effects of e-cigarette use on lung function. 电子烟使用对肺功能影响的系统综述。

IF 3.1 3区医学

NPJ Primary Care Respiratory Medicine Pub Date : 2022-10-22 DOI: 10.1038/s41533-022-00311-w

Lucy Honeycutt, Katherine Huerne, Alanna Miller, Erica Wennberg, Kristian B Filion, Roland Grad, Andrea S Gershon, Carolyn Ells, Genevieve Gore, Andrea Benedetti, Brett Thombs, Mark J Eisenberg

{"title":"A systematic review of the effects of e-cigarette use on lung function.","authors":"Lucy Honeycutt, Katherine Huerne, Alanna Miller, Erica Wennberg, Kristian B Filion, Roland Grad, Andrea S Gershon, Carolyn Ells, Genevieve Gore, Andrea Benedetti, Brett Thombs, Mark J Eisenberg","doi":"10.1038/s41533-022-00311-w","DOIUrl":"https://doi.org/10.1038/s41533-022-00311-w","url":null,"abstract":"Given the increasing use of e-cigarettes and uncertainty surrounding their safety, we conducted a systematic review to determine the effects of e-cigarettes on measures of lung function. We systematically searched EMBASE, MEDLINE, and PsycINFO databases via Ovid, the Cochrane CENTRAL database, and the Web of Science Core from 2004 until July 2021, identifying 8856 potentially eligible studies. A total of eight studies (seven studying immediate effects and one long-term effects, 273 total participants) were included. The risk of bias was assessed using the Risk of Bias in Non-randomized Studies-of Interventions (ROBINS-I) and Cochrane risk of bias tools. These studies suggest that vaping increases airway resistance but does not appear to impact forced expiratory volume in one second (FEV1), forced vital capacity (FVC), or FEV1/FVC ratio. However, given the limited size and follow-up duration of these studies, larger, long-term studies are required to further determine the effects of e-cigarettes on lung function.","PeriodicalId":19470,"journal":{"name":"NPJ Primary Care Respiratory Medicine","volume":" ","pages":"45"},"PeriodicalIF":3.1,"publicationDate":"2022-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9588082/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40579932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Understanding relationships between asthma medication use and outcomes in a SABINA primary care database study. 了解哮喘药物使用与SABINA初级保健数据库研究结果之间的关系。

IF 3.1 3区医学

NPJ Primary Care Respiratory Medicine Pub Date : 2022-10-21 DOI: 10.1038/s41533-022-00310-x

Marcia Vervloet, Liset van Dijk, Yvette M Weesie, Janwillem W H Kocks, Alexandra L Dima, Joke C Korevaar

{"title":"Understanding relationships between asthma medication use and outcomes in a SABINA primary care database study.","authors":"Marcia Vervloet, Liset van Dijk, Yvette M Weesie, Janwillem W H Kocks, Alexandra L Dima, Joke C Korevaar","doi":"10.1038/s41533-022-00310-x","DOIUrl":"https://doi.org/10.1038/s41533-022-00310-x","url":null,"abstract":"Adherence to inhaled corticosteroids (ICS) in asthma is suboptimal. Patients may rely more on their short-acting beta-agonist (SABA) to control symptoms, which may increase their risk of exacerbations and uncontrolled asthma. Our objective is to describe ICS adherence and SABA use among Dutch primary care patients with asthma, and how these are related to exacerbations and self-reported asthma control. Patients aged ≥12 years diagnosed with asthma who received ≥2 inhalation medication prescriptions in 2016 were selected from the Nivel Primary Care Database. ICS adherence (continuous measure of medication availability), SABA use (number of prescriptions), exacerbations (short courses of oral corticosteroids with daily dose ≥20 mg), and asthma control (self-reported with the Asthma Control Questionnaire; ACQ) were computed. Multilevel logistic regression analyses, to account for clustering of patients within practices, were used to model associations between ICS adherence, SABA use, and asthma outcomes. Prescription data of 13,756 patients were included. ICS adherence averaged 62% (SD: 32.7), 14% of patients received ≥3 SABA prescriptions, and 13% of patients experienced ≥1 exacerbation. Self-reported asthma control was available for 2183 patients of whom 51% reported controlled asthma (ACQ-5 score <0.75). A higher number of SABA prescriptions was associated with a higher risk of exacerbations and uncontrolled asthma, even with high ICS adherence (>90%). ICS adherence was not associated with exacerbations, whilst poor ICS adherence (≤50%) was associated with uncontrolled asthma. In conclusion, increased SABA use is an important and easily identifiable signal for general practitioners to discuss asthma self-management behavior with their patients.","PeriodicalId":19470,"journal":{"name":"NPJ Primary Care Respiratory Medicine","volume":"32 1","pages":"43"},"PeriodicalIF":3.1,"publicationDate":"2022-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9587241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9202065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Documentation of smoking in scheduled asthma contacts in primary health care: a 12-year follow-up study. 初级卫生保健中哮喘接触者吸烟记录:一项12年随访研究

IF 3.1 3区医学

NPJ Primary Care Respiratory Medicine Pub Date : 2022-10-21 DOI: 10.1038/s41533-022-00309-4

Jaana Takala, Iida Vähätalo, Leena E Tuomisto, Onni Niemelä, Pinja Ilmarinen, Hannu Kankaanranta

{"title":"Documentation of smoking in scheduled asthma contacts in primary health care: a 12-year follow-up study.","authors":"Jaana Takala, Iida Vähätalo, Leena E Tuomisto, Onni Niemelä, Pinja Ilmarinen, Hannu Kankaanranta","doi":"10.1038/s41533-022-00309-4","DOIUrl":"https://doi.org/10.1038/s41533-022-00309-4","url":null,"abstract":"Smoking among asthmatics is common and associates with poorer asthma control, more rapid lung function decline and higher health care costs in dose-dependent manner. No previous real-life studies exist, however, on how smoking status and pack-years are documented in scheduled asthma contacts in primary health care (PHC) during long-term follow-up, and how often patients are advised to quit smoking. In this real-life 12-year follow-up study, we showed that out of all scheduled PHC asthma contacts (n = 603) smoking was mentioned only in 17.2% and pack-years only in 6.5%. Smoking data was not recorded even once in 70.9% of never smokers, 64.7% of ex-smokers and 27.3% of current smokers. Smoking including pack-years were mentioned more often if nurse took part on the scheduled contact. For current smokers, smoking cessation was recommended only in 21.7% of their scheduled contacts. Current smokers used more antibiotics and had more unscheduled health care contacts during follow-up.","PeriodicalId":19470,"journal":{"name":"NPJ Primary Care Respiratory Medicine","volume":" ","pages":"44"},"PeriodicalIF":3.1,"publicationDate":"2022-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9587006/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40578421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A systematic review of interventions to recognise, refer and diagnose patients with lung cancer symptoms. 对识别、转诊和诊断肺癌症状患者的干预措施进行系统回顾。

IF 3.1 3区医学

NPJ Primary Care Respiratory Medicine Pub Date : 2022-10-18 DOI: 10.1038/s41533-022-00312-9

Mohamad M Saab, Megan McCarthy, Michelle O'Driscoll, Laura J Sahm, Patricia Leahy-Warren, Brendan Noonan, Serena FitzGerald, Maria O'Malley, Noreen Lyons, Heather E Burns, Una Kennedy, Áine Lyng, Josephine Hegarty

{"title":"A systematic review of interventions to recognise, refer and diagnose patients with lung cancer symptoms.","authors":"Mohamad M Saab, Megan McCarthy, Michelle O'Driscoll, Laura J Sahm, Patricia Leahy-Warren, Brendan Noonan, Serena FitzGerald, Maria O'Malley, Noreen Lyons, Heather E Burns, Una Kennedy, Áine Lyng, Josephine Hegarty","doi":"10.1038/s41533-022-00312-9","DOIUrl":"https://doi.org/10.1038/s41533-022-00312-9","url":null,"abstract":"Patients with lung cancer (LC) often experience delay between symptom onset and treatment. Primary healthcare professionals (HCPs) can help facilitate early diagnosis of LC through recognising early signs and symptoms and making appropriate referrals. This systematic review describes the effect of interventions aimed at helping HCPs recognise and refer individuals with symptoms suggestive of LC. Seven studies were synthesised narratively. Outcomes were categorised into: Diagnostic intervals; referral and diagnosis patterns; stage distribution at diagnosis; and time interval from diagnosis to treatment. Rapid access pathways and continuing medical education for general practitioners can help reduce LC diagnostic and treatment delay. Awareness campaigns and HCP education can help inform primary HCPs about referral pathways. However, campaigns did not significantly impact LC referral rates or reduce diagnostic intervals. Disease outcomes, such as LC stage at diagnosis, recurrence, and survival were seldom measured. Review findings highlight the need for longitudinal, powered, and controlled studies.","PeriodicalId":19470,"journal":{"name":"NPJ Primary Care Respiratory Medicine","volume":" ","pages":"42"},"PeriodicalIF":3.1,"publicationDate":"2022-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579201/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40340423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

A systematic review on the association of sleep-disordered breathing with cardiovascular pathology in adults. 成人睡眠呼吸障碍与心血管疾病相关性的系统综述

IF 3.1 3区医学

NPJ Primary Care Respiratory Medicine Pub Date : 2022-10-17 DOI: 10.1038/s41533-022-00307-6

Anna Khokhrina, Elena Andreeva, Jean-Marie Degryse

{"title":"A systematic review on the association of sleep-disordered breathing with cardiovascular pathology in adults.","authors":"Anna Khokhrina, Elena Andreeva, Jean-Marie Degryse","doi":"10.1038/s41533-022-00307-6","DOIUrl":"https://doi.org/10.1038/s41533-022-00307-6","url":null,"abstract":"Sleep-disordered breathing (SDB) is characterized by repeated breathing pauses during sleep. The prevalence of SDB varies widely between studies. Some longitudinal studies have found an association of SDB with incident or recurrent cardiovascular events. We sought to systematically describe the current data on the correlation between SDB and cardiovascular pathology. Studies were included if they were original observational population-based studies in adults with clearly diagnosed SDB. The primary outcomes include all types of cardiovascular pathology. We carried out pooled analyses using a random effects model. Our systematic review was performed according to the PRISMA and MOOSE guidelines for systematic reviews and was registered with PROSPERO. In total, 2652 articles were detected in the databases, of which 76 articles were chosen for full-text review. Fourteen studies were focused on samples of an unselected population, and 8 studies were focused on a group of persons at risk for SDB. In 5 studies, the incidence of cardiovascular pathology in the population with SDB was examined. In total, 49 studies described SDB in patients with cardiovascular pathology. We found an association between SDB and prevalent /incident cardiovascular disease (pooled OR 1.76; 95% CI 1.38-2.26), and pooled HR (95% CI 1.78; 95% CI 1.34-2.45). Notably, in patients with existing SDB, the risk of new adverse cardiovascular events was high. However, the relationship between cardiovascular disease and SDB is likely to be bidirectional. Thus, more large-scale studies are needed to better understand this association and to decide whether screening for possible SDB in cardiovascular patients is reasonable and clinically significant.","PeriodicalId":19470,"journal":{"name":"NPJ Primary Care Respiratory Medicine","volume":" ","pages":"41"},"PeriodicalIF":3.1,"publicationDate":"2022-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576790/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40395453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Breaking the vicious circle-the Asthma Referral Identifier (ReferID) tool. 打破恶性循环-哮喘转诊标识(ReferID)工具。

IF 3.1 3区医学

NPJ Primary Care Respiratory Medicine Pub Date : 2022-10-08 DOI: 10.1038/s41533-022-00296-6

Maarten Beekman, Julie Hales, Mona Al-Ahmad, Ricardo Del Olmo, Tze Lee Tan

{"title":"Breaking the vicious circle-the Asthma Referral Identifier (ReferID) tool.","authors":"Maarten Beekman, Julie Hales, Mona Al-Ahmad, Ricardo Del Olmo, Tze Lee Tan","doi":"10.1038/s41533-022-00296-6","DOIUrl":"https://doi.org/10.1038/s41533-022-00296-6","url":null,"abstract":"Asthma is associated with a significant burden of disease, especially for patients with severe or uncontrolled asthma. Many patients with severe asthma still receive treatment in primary care settings and despite the availability of effective options, inadequate asthma treatment remains a concern, particularly the use of systemic corticosteroids to treat exacerbations and severe asthma. Around the world, many patients are stuck in a vicious circle of misdiagnosis, undertreatment, and poor understanding of disease severity and management. In this manuscript, we describe the development of The Asthma Referral Identifier (ReferID) tool, a simple, 4-item questionnaire that healthcare providers can use to help identify patients with uncontrolled and/or potentially severe asthma. ReferID was developed specifically for use in primary care clinics in low- and middle-income countries and other clinics, where the optimisation of asthma assessments and treatment recommended for countries with well-established healthcare systems, are not possible. ReferID was developed through an informal collaborative process involving international asthma experts as well as general practitioners, nurses, and specialists throughout the Asia Pacific, Latin America and Middle East regions, in conjunction with current evidence and treatment guidelines. In collaboration with local and regional partners around the world, the developers have adapted ReferID and translated it into 21 languages, and implementation is ongoing in 30 countries. ReferID has the potential to help break the vicious circle, improving disease outcomes and health-related quality of life for patients with asthma.","PeriodicalId":19470,"journal":{"name":"NPJ Primary Care Respiratory Medicine","volume":" ","pages":"40"},"PeriodicalIF":3.1,"publicationDate":"2022-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9547879/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33495203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Pharmacological smoking cessation of adults aged 30-50 years with COPD. 30-50岁成人慢性阻塞性肺病患者的药物戒烟

IF 3.1 3区医学

NPJ Primary Care Respiratory Medicine Pub Date : 2022-10-08 DOI: 10.1038/s41533-022-00301-y

Dea Kejlberg Andelius, Ole Hilberg, Rikke Ibsen, Anders Løkke

{"title":"Pharmacological smoking cessation of adults aged 30-50 years with COPD.","authors":"Dea Kejlberg Andelius, Ole Hilberg, Rikke Ibsen, Anders Løkke","doi":"10.1038/s41533-022-00301-y","DOIUrl":"https://doi.org/10.1038/s41533-022-00301-y","url":null,"abstract":"The prevalence of active smokers has remained relatively stable around 20% for several years in Denmark despite knowledge of the harmful effects. Smoking cessation is the most effective way to limit progression and reduce mortality of chronic obstructive pulmonary disease (COPD). Therefore, smoking cessation is particularly important among adults with COPD. The aim of this study was to determine the extent to which adults 30-50 years of age with COPD redeem pharmacotherapy for smoking cessation, and to identify demographic factors that influence the use of smoking cessation medication. We conducted a national retrospective non-interventional registry study, including all Danish patients with COPD (ICD-10 code J.44: chronic obstructive pulmonary disease) aged 30-50 years in the period 2009-2015. We identified 7734 cases, who were matched with controls (15,307) 1:2 on age, sex, and geography. Smoking status was not registered. We found that 18% of cases (with an estimated smoking prevalence at 33-50%) redeemed pharmacological smoking cessation medication in the study period compared to 3% of the controls (with an estimated smoking prevalence at 23%). The OR for cases collecting pharmacological smoking cessation medication was 5.92 [95% CI 5.24-6.70]. Male sex, being unemployed, and receiving social benefits were factors associated with less probability of redeeming pharmacological smoking cessation medication. Our study indicates that attention is needed on smoking cessation in adults aged 30-50 years with COPD, especially if unemployed or receiving social benefits, as these individuals are less likely to redeem pharmacological smoking cessation medication.","PeriodicalId":19470,"journal":{"name":"NPJ Primary Care Respiratory Medicine","volume":" ","pages":"39"},"PeriodicalIF":3.1,"publicationDate":"2022-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9547921/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33494452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

A meta-analysis on the structure of pulmonary rehabilitation maintenance programmes on COPD patients' functional capacity. 肺康复维持计划对慢性阻塞性肺病患者功能能力影响的荟萃分析。

IF 3.1 3区医学

NPJ Primary Care Respiratory Medicine Pub Date : 2022-10-03 DOI: 10.1038/s41533-022-00302-x

Liliana Silva, Tiago Maricoto, Patrício Costa, Joana Berger-Estilita, José Miguel Padilha

{"title":"A meta-analysis on the structure of pulmonary rehabilitation maintenance programmes on COPD patients' functional capacity.","authors":"Liliana Silva, Tiago Maricoto, Patrício Costa, Joana Berger-Estilita, José Miguel Padilha","doi":"10.1038/s41533-022-00302-x","DOIUrl":"10.1038/s41533-022-00302-x","url":null,"abstract":"Pulmonary rehabilitation (PR) improves functional capacity, health-related quality of life (HRQoL) in COPD patients, and maintenance programmes are relevant in preserving those improvements. However, little is known about the structure of maintenance programmes after PR. We performed a systematic review and meta-analysis of experimental and quasi-experimental studies evaluating individuals with COPD admitted to a maintenance PR programme, delivered after an initial PR programme. We reported functional capacity evaluation (6-minute-walking-test), HRQoL, dyspnoea and symptom control. Searches were performed on the 11th April 2021 using MEDLINE, Embase, EBSCO, CINAHL, Web of Science and Cochrane Library. We extracted summary-level data from trial publications and used a random-effects model, predicting that severe heterogeneity was detected. The protocol was registered in PROSPERO (CRD42021247724). Fifteen studies were included in the meta-analysis, with 1151 participants. Maintenance programmes were associated with a pooled mean increase of 27.08 meters in 6mWT (CI: 10.39 to 43.77; I2 = 93%; p < 0.0001), being better in supervised, long (>12 month) home-based programmes; and having a potential MD of -4.20 pts in SGRQ (CI: -4.49 to -3.91; I2 = 0%; p = 0.74). Regarding dyspnoea and exacerbations, we found a nonsignificant trend for improvement after maintenance PR programmes. Severe COPD patients showed smaller improvements in programmes up to a year. Overall, the strength of the underlying evidence was moderate. Despite limitations of risk of bias and heterogeneity, our results support that home-based, supervised, long-term maintenance PR programmes may significantly improve functional capacity in COPD patients and HRQoL.","PeriodicalId":19470,"journal":{"name":"NPJ Primary Care Respiratory Medicine","volume":" ","pages":"38"},"PeriodicalIF":3.1,"publicationDate":"2022-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530215/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40394889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Short-acting β₂-agonist prescription patterns for asthma management in the SABINA III primary care cohort. SABINA III初级保健队列哮喘管理的短效β2激动剂处方模式

IF 3.1 3区医学

NPJ Primary Care Respiratory Medicine Pub Date : 2022-09-29 DOI: 10.1038/s41533-022-00295-7

David Price, Kerry Hancock, Joseph Doan, Sri Wahyu Taher, Chakaya J Muhwa, Hisham Farouk, Maarten J H I Beekman

{"title":"Short-acting β2-agonist prescription patterns for asthma management in the SABINA III primary care cohort.","authors":"David Price, Kerry Hancock, Joseph Doan, Sri Wahyu Taher, Chakaya J Muhwa, Hisham Farouk, Maarten J H I Beekman","doi":"10.1038/s41533-022-00295-7","DOIUrl":"https://doi.org/10.1038/s41533-022-00295-7","url":null,"abstract":"Short-acting β2-agonist (SABA) prescriptions and associated outcomes were assessed in 1440 patients with asthma from the SABA use IN Asthma (SABINA) III study treated in primary care. Data on asthma medications were collected, and multivariable regression models analysed the association of SABA prescriptions with clinical outcomes. Patients (mean age, 47.9 years) were mostly female (68.6%); 58.3% had uncontrolled/partly controlled asthma and 38.8% experienced ≥1 severe exacerbation (reported in 39% of patients with mild asthma). Overall, 44.9% of patients were prescribed ≥3 SABA canisters (over-prescription) and 21.5% purchased SABA over-the-counter. Higher SABA prescriptions (vs 1-2 canisters) were associated with significantly decreased odds of having at least partly controlled asthma (6-9 and 10-12 canisters) and an increased incidence rate of severe exacerbations (10-12 and ≥13 canisters). Findings revealed a high disease burden, even in patients with 'mild' asthma, emphasising the need for local primary care guidelines based on international recommendations.","PeriodicalId":19470,"journal":{"name":"NPJ Primary Care Respiratory Medicine","volume":" ","pages":"37"},"PeriodicalIF":3.1,"publicationDate":"2022-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9522811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40382952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Estimation of lung age via a spline method and its application in chronic respiratory diseases. 样条法估计肺年龄及其在慢性呼吸系统疾病中的应用。

IF 3.1 3区医学

NPJ Primary Care Respiratory Medicine Pub Date : 2022-09-29 DOI: 10.1038/s41533-022-00293-9

Xiaolin Liang, Yanqing Xie, Yi Gao, Yumin Zhou, Wenhua Jian, Mei Jiang, Hongyu Wang, Jinping Zheng

{"title":"Estimation of lung age via a spline method and its application in chronic respiratory diseases.","authors":"Xiaolin Liang, Yanqing Xie, Yi Gao, Yumin Zhou, Wenhua Jian, Mei Jiang, Hongyu Wang, Jinping Zheng","doi":"10.1038/s41533-022-00293-9","DOIUrl":"https://doi.org/10.1038/s41533-022-00293-9","url":null,"abstract":"Lung age is a simplified concept that makes spirometry data easier to understand, but it is not widely used due to limitations in estimation methods. The aim of this study was to develop new equations to estimate lung age and to explore the application value of lung age in chronic respiratory diseases. Retrospective spirometric data of 18- to 80-year-old healthy subjects were used to develop the lung age estimation equations. Models were respectively built by multiple linear regression, piecewise linear regression, and the natural cubic spline method. Patients with chronic obstructive pulmonary disease (COPD) and asthma were subdivided into stages I-IV according to the severity of airflow limitation under the recommendation of the Global Initiative for Chronic Obstructive Lung Disease. Propensity score matching was performed to balance age, height and sex between healthy subjects and patients. The difference between lung age and chronological age (∆ lung age) of patients with COPD and asthma was analyzed. A total of 3409 healthy subjects, 280 patients with COPD and 285 patients with asthma data were included in the analysis. The lung age estimation equation with the best goodness of fit was built by the spline method and composed of FEV1, FEF50%, FEF75% and height as explanatory variables. ∆ lung age progressively increased with the degree of airflow limitation in patients with COPD or asthma. Lung age estimation equations were developed by a spline modeling method. Lung age may be used in the assessment of chronic respiratory patients.","PeriodicalId":19470,"journal":{"name":"NPJ Primary Care Respiratory Medicine","volume":" ","pages":"36"},"PeriodicalIF":3.1,"publicationDate":"2022-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9522795/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40383548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1