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Reply to: Toward Enhanced Methodological Rigor: Addressing Limitations in the Comparative Analysis of Probiotics and Antidepressants for Major Depressive Disorder Management. 答复方法论严谨性的提升:解决益生菌和抗抑郁药治疗重度抑郁障碍比较分析中的局限性。
IF 5.9 2区 医学
Nutrition reviews Pub Date : 2024-10-14 DOI: 10.1093/nutrit/nuae139
Shilin Zhao, Jun Tao, Suisha Liang, Hein M Tun
{"title":"Reply to: Toward Enhanced Methodological Rigor: Addressing Limitations in the Comparative Analysis of Probiotics and Antidepressants for Major Depressive Disorder Management.","authors":"Shilin Zhao, Jun Tao, Suisha Liang, Hein M Tun","doi":"10.1093/nutrit/nuae139","DOIUrl":"https://doi.org/10.1093/nutrit/nuae139","url":null,"abstract":"","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142471249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetic Signature of a Healthy Lifestyle: New Horizons for Preventing Noncommunicable Chronic Diseases by Modulating MicroRNA-155. 健康生活方式的基因特征:通过调节 MicroRNA-155 预防非传染性慢性疾病的新视野。
IF 5.9 2区 医学
Nutrition reviews Pub Date : 2024-10-09 DOI: 10.1093/nutrit/nuae142
Karen S Coutinho-Wolino, Michele L Brito, Pricilla C Trigueira, Larissa O de Menezes, Clara S do Nascimento, Milena B Stockler-Pinto
{"title":"Genetic Signature of a Healthy Lifestyle: New Horizons for Preventing Noncommunicable Chronic Diseases by Modulating MicroRNA-155.","authors":"Karen S Coutinho-Wolino, Michele L Brito, Pricilla C Trigueira, Larissa O de Menezes, Clara S do Nascimento, Milena B Stockler-Pinto","doi":"10.1093/nutrit/nuae142","DOIUrl":"https://doi.org/10.1093/nutrit/nuae142","url":null,"abstract":"<p><p>The development and progression of several noncommunicable diseases (NCDs) are associated with microRNA (miR) 155 (miR-155) activation, which promotes inflammation and oxidative stress. In particular, miR-155 regulates nuclear transcription factor-kappa B (NF-κB) by silencing gene expression of proteins involved in NF-κB suppression, such as suppressor of cytokine signaling 1 (SOCS1) and SH-2 containing inositol 5' polyphosphate 1 (SHIP1), increases the production of reactive oxygen species, and suppresses gene expression of antioxidant enzymes through nuclear factor erythroid 2-related factor 2 (Nrf2) inhibition. In this context, a healthy lifestyle based on a diet rich in nutrients and bioactive compounds as well as regular physical activity may modulate the activity of several miRs. Following this concept, studies involving nutrients, bioactive compounds, and physical activity have been developed to modulate miR-155 activation. This narrative review aims to discuss how a healthy lifestyle based on a diet rich in nutrients, bioactive compounds, and physical activity may modulate the miR-155 pathway and consequently prevent the development and progression of NCDs. Nutrients and bioactive compounds from food may act by inhibiting pathways that promote miR-155 activation such as NF-κB and promote activation of pathways that are associated with the downregulation of miR-155, such as Nrf2, and SOCS1 pathways. Regular physical activity also seems to influence miR-155 levels through an improvement in the immune system during muscle recovery. There is relevant evidence that shows a positive effect of nutrients, bioactive compounds, and physical activity with the modulation of miR-155, which can potentially provide benefits in the clinical setting in cases of NCDs.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142392210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mapping the Evidence for Measuring Energy Expenditure and Indicating Hypermetabolism in Motor Neuron Disease: A Scoping Review. 运动神经元疾病中测量能量消耗和指示代谢过剩的证据图谱:范围综述》。
IF 5.9 2区 医学
Nutrition reviews Pub Date : 2024-10-07 DOI: 10.1093/nutrit/nuae118
Sarah A Roscoe, Scott P Allen, Christopher J McDermott, Theocharis Stavroulakis
{"title":"Mapping the Evidence for Measuring Energy Expenditure and Indicating Hypermetabolism in Motor Neuron Disease: A Scoping Review.","authors":"Sarah A Roscoe, Scott P Allen, Christopher J McDermott, Theocharis Stavroulakis","doi":"10.1093/nutrit/nuae118","DOIUrl":"https://doi.org/10.1093/nutrit/nuae118","url":null,"abstract":"<p><strong>Objective: </strong>To map the international methods used to measure energy expenditure of adults living with motor neuron disease (MND) and to highlight discrepancies when indicating hypermetabolism in the MND literature.</p><p><strong>Background: </strong>A decline in the nutritional status of patients is associated with exacerbated weight loss and shortened survival. Assessments of energy expenditure, using a variety of methods, are important to ensure an adequate energy intake to prevent malnutrition-associated weight loss. Assessments of energy expenditure are also commonly used to indicate hypermetabolism in MND, although these approaches may not be optimal.</p><p><strong>Methods: </strong>A protocol based on the Preferred Reporting Items for Systematic Reviews and Meta-analyses extension for Scoping Reviews Guidelines was developed. Three electronic databases (Medline [Ovid], CINAHL [EBSCO], and Web of Science) were exhaustively searched. Identified publications were systematically screened according to predefined PICOS eligibility criteria. The primary outcome was the identification of methods used to measure energy expenditure in MND. The secondary outcome was the identification of applications of energy expenditure assessments to indicate hypermetabolism in MND.</p><p><strong>Results: </strong>Thirty-two observational primary research publications were identified. Thirteen (40.6%) were longitudinal in design, with data on repeated measurements of energy expenditure presented in 3 (9.4%). Thirteen (40.6%) were case-control studies, of which 11 use a matched control group. Pulmonary function was used to assess eligibility in 10 publications. Energy expenditure was measured using indirect calorimetry (IC) in 31 studies. Discrepancies in the durations of fasted, measurement, and washout periods were observed. Of all included publications, 50% used assessments of resting energy expenditure to identify hypermetabolism. Bioelectrical impedance analysis was used to assess body composition alongside energy expenditure in 93.8% of publications.</p><p><strong>Conclusions: </strong>Resting energy expenditure is most frequently measured using an open-circuit IC system. However, there is a lack of a standardized, validated protocol for the conduct and reporting of IC and metabolic status in patients with MND.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142392211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Systematic Review of the Beneficial Effects of Berry Extracts on Non-Alcoholic Fatty Liver Disease in Animal Models. 浆果提取物对动物模型非酒精性脂肪肝有益作用的系统综述
IF 5.9 2区 医学
Nutrition reviews Pub Date : 2024-10-04 DOI: 10.1093/nutrit/nuae132
Alejandro García-Beltrán, Aida Lozano Melero, Rosario Martínez Martínez, Jesús María Porres Foulquie, María López Jurado Romero de la Cruz, Garyfallia Kapravelou
{"title":"A Systematic Review of the Beneficial Effects of Berry Extracts on Non-Alcoholic Fatty Liver Disease in Animal Models.","authors":"Alejandro García-Beltrán, Aida Lozano Melero, Rosario Martínez Martínez, Jesús María Porres Foulquie, María López Jurado Romero de la Cruz, Garyfallia Kapravelou","doi":"10.1093/nutrit/nuae132","DOIUrl":"https://doi.org/10.1093/nutrit/nuae132","url":null,"abstract":"<p><strong>Context: </strong>Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in Western countries and is strongly associated with several metabolic disorders. Plant-derived bioactive extracts, such as berry extracts, with high antioxidant capacity have been used for the treatment and prevention of this pathology. Moreover, they promote circular economy and sustainability.</p><p><strong>Objective: </strong>To study the beneficial effects of extracts from different parts of berry plants in animal models of NAFLD.</p><p><strong>Data sources: </strong>A systematic research of the MEDLINE (via PubMed), Cochrane, and Scopus databases was conducted to identify relevant studies published after January 2011. In vivo animal studies of NAFLD were included in which berry extracts of different parts of the plant were administered and significantly improved altered biomarkers related to the pathology, such as lipid metabolism and hepatic steatosis, glucose and glycogen metabolism, and antioxidant and anti-inflammatory biomarkers.</p><p><strong>Data extraction: </strong>Of a total of 203 articles identified, 31 studies were included after implementation of the inclusion and exclusion criteria.</p><p><strong>Data analysis: </strong>Most of the studies showed a decrease in steatosis and a stimulation of genes related to β-oxidation and downregulation of lipogenic genes, with administration of berry extracts. Berry extracts also attenuated inflammation and oxidative stress.</p><p><strong>Conclusions: </strong>Administration of berry extracts seems to have promising potential in the design of enriched foodstuffs or nutraceuticals for the treatment of NAFLD.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142375775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Longitudinal Evidence on Social Ties and Fruit and Vegetable Intake among Aging Adults: A Systematic Review. 社会关系与老年人水果和蔬菜摄入量的纵向证据:系统回顾
IF 5.9 2区 医学
Nutrition reviews Pub Date : 2024-10-04 DOI: 10.1093/nutrit/nuae134
Sanaz Mehranfar, Rana Madani Civi, Riley Plunkett, Rachel A Murphy, Tamara R Cohen, Annalijn I Conklin
{"title":"The Longitudinal Evidence on Social Ties and Fruit and Vegetable Intake among Aging Adults: A Systematic Review.","authors":"Sanaz Mehranfar, Rana Madani Civi, Riley Plunkett, Rachel A Murphy, Tamara R Cohen, Annalijn I Conklin","doi":"10.1093/nutrit/nuae134","DOIUrl":"https://doi.org/10.1093/nutrit/nuae134","url":null,"abstract":"<p><strong>Context: </strong>Social ties are associated with the mortality and morbidity of aging populations; however, the role of social ties in healthy eating practices or gender differences in this link is less understood.</p><p><strong>Objective: </strong>The objective of this study was to examine the longitudinal evidence for the impact of changes in social ties on fruit and vegetable (FV) intakes among aging adults, with attention to gender differences.</p><p><strong>Data sources: </strong>Medline, Embase, Scopus, CINAHL, and ProQuest databases were searched until December 2022.</p><p><strong>Data extraction: </strong>Longitudinal studies evaluating changes in living arrangement, marital status, social network, or social participation and changes in FV intake among middle- and older-age adults were included. Data from the included studies were extracted using a standardized template and analyzed using a narrative approach.</p><p><strong>Data analysis: </strong>A total of 4956 titles were eligible after deduplication, and 75 full texts were screened. Seven studies met the inclusion criteria, and all examined marital transitions only. Five marital transitions were assessed: staying married, becoming widowed, becoming divorced, remaining unmarried, and becoming married. Both the quantity and variety of fruit and/or vegetables eaten were studied. Three of the included studies had only male or only female populations. The studies found that marital dissolution (divorce or widowhood), and remaining unmarried, were associated with reduced FV intakes in older women or men, compared with staying married. The associations were stronger in men than in women. Two studies showed that becoming married was associated with increased vegetable intakes, but 3 reported null results. The included studies were of medium quality.</p><p><strong>Conclusions: </strong>There is a paucity of longitudinal research on whether changes in social ties are associated with changes in FV intakes among aging adults. This review showed that specific marital transitions may influence healthy eating habits, especially in older men. No evidence exists on whether changes in other social ties might alter healthy eating.</p><p><strong>Systematic review registration: </strong>PROSPERO registration No. CRD42022365795.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142375777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Health Benefits From Diets High in Salicylates May Arise From Improved Utilization of Dietary Copper. 水杨酸盐含量高的膳食对健康的益处可能来自对膳食铜的更好利用。
IF 5.9 2区 医学
Nutrition reviews Pub Date : 2024-10-04 DOI: 10.1093/nutrit/nuae147
Leslie M Klevay
{"title":"Health Benefits From Diets High in Salicylates May Arise From Improved Utilization of Dietary Copper.","authors":"Leslie M Klevay","doi":"10.1093/nutrit/nuae147","DOIUrl":"https://doi.org/10.1093/nutrit/nuae147","url":null,"abstract":"","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142375776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ultra-processed food intake among South Asians in the United States: Specific vulnerabilities of a growing immigrant population group. 美国南亚人的超加工食品摄入:不断增长的移民群体的特殊脆弱性。
IF 5.9 2区 医学
Nutrition reviews Pub Date : 2024-10-01 DOI: 10.1093/nutrit/nuad126
Bridget Murphy Hussain, Filippa Juul, Andrea L Deierlein, Niyati Parekh
{"title":"Ultra-processed food intake among South Asians in the United States: Specific vulnerabilities of a growing immigrant population group.","authors":"Bridget Murphy Hussain, Filippa Juul, Andrea L Deierlein, Niyati Parekh","doi":"10.1093/nutrit/nuad126","DOIUrl":"10.1093/nutrit/nuad126","url":null,"abstract":"<p><p>South Asians are among the fastest growing immigrant population groups in the United States. Their traditional diets are rich in minimally processed fruits, vegetables, grains, herbs, and spices. However, the proliferation of ultra-processed foods (highly processed, industrially manufactured formulations) around the globe may compromise the nutrition profile of South Asians, threatening to increase their risk of noncommunicable diseases. This commentary discusses the rise in ultra-processed food consumption among South Asians in the United States and hypothesizes that South Asians may be especially vulnerable to the effects of ultra-processed foods due to their unique cardiovascular disease risk profiles. Using these emerging data, we propose several strategies for preventing the overconsumption of ultra-processed foods among South Asian Americans. These include the implementation of policies to encourage the consumption of whole foods over ultra-processed foods and the development of culturally tailored interventions, which include promoting consumption of traditional diets, improving affordability of healthful, culturally appropriate foods, and cultivating healthier food environments for South Asians living in the United States.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":"1402-1406"},"PeriodicalIF":5.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11384113/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49680411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Intertwinement of the Physical and Digital Worlds in the Development of Food Literacy Competencies. 物质世界和数字世界在培养食品知识能力方面的相互交织。
IF 5.9 2区 医学
Nutrition reviews Pub Date : 2024-09-30 DOI: 10.1093/nutrit/nuae137
Gaston Ares, Sofia De Rosso, Carina Mueller, Kaat Philippe, Abigail Pickard, Sophie Nicklaus, Ellen van Kleef, Paula Varela
{"title":"The Intertwinement of the Physical and Digital Worlds in the Development of Food Literacy Competencies.","authors":"Gaston Ares, Sofia De Rosso, Carina Mueller, Kaat Philippe, Abigail Pickard, Sophie Nicklaus, Ellen van Kleef, Paula Varela","doi":"10.1093/nutrit/nuae137","DOIUrl":"https://doi.org/10.1093/nutrit/nuae137","url":null,"abstract":"","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142351129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unveiling the Effects of Cruciferous Vegetable Intake on Different Cancers: A Systematic Review and Dose-Response Meta-analysis. 揭示十字花科蔬菜摄入对不同癌症的影响:系统回顾与剂量反应荟萃分析》(A Systematic Review and Dose-Response Meta-analysis)。
IF 5.9 2区 医学
Nutrition reviews Pub Date : 2024-09-30 DOI: 10.1093/nutrit/nuae131
Sicong Zheng, Jielin Yan, Jiaxin Wang, Xinyi Wang, Yea Eun Kang, Bon Seok Koo, Yujuan Shan, Lihua Liu
{"title":"Unveiling the Effects of Cruciferous Vegetable Intake on Different Cancers: A Systematic Review and Dose-Response Meta-analysis.","authors":"Sicong Zheng, Jielin Yan, Jiaxin Wang, Xinyi Wang, Yea Eun Kang, Bon Seok Koo, Yujuan Shan, Lihua Liu","doi":"10.1093/nutrit/nuae131","DOIUrl":"https://doi.org/10.1093/nutrit/nuae131","url":null,"abstract":"<p><strong>Context: </strong>Epidemiological studies indicated that cruciferous vegetable intake is associated with positive health outcomes. However, the role of cruciferous vegetables may have differential impacts on various cancers.</p><p><strong>Objective: </strong>This meta-analysis aims to review recent epidemiological studies on the link between cruciferous vegetables and various cancers. It seeks to identify the optimal intake dose and timing of cruciferous vegetables influencing their association with cancer risk.</p><p><strong>Data sources: </strong>Studies on cruciferous vegetables and cancer were searched in PubMed, NCBI, Web of Science, and Elsevier databases from 1978 to June 2023.</p><p><strong>Data extraction: </strong>Extracted data from 226 relevant case-control and cohort studies were expressed by standardized mean difference and 95% CI, followed by the subgroup analysis to eliminate heterogeneity.</p><p><strong>Results: </strong>Intake of cruciferous vegetables can prevent cancers, with an odds ratio of 0.77 and risk ratio (RR) of 0.96. The intake levels of cruciferous vegetables associated with the risk of colorectal cancer, lung cancer, upper gastrointestinal cancer, gynecological cancer (ovarian cancer and endometrial cancer), bladder cancer, renal cancer, and prostate cancer were found to be 5.41 servings/week, 5.41 servings/week, 5.5 servings/week, 7.4 servings/week, 5.5 servings/week, 4.85 servings/week, and 3 servings/week, respectively. In a cohort followed for 2 to 15 years, limited consumption of cruciferous vegetables was correlated with a higher cancer RR. In the Asian population, cruciferous vegetables had a significant relationship with lung cancer, head and neck squamous cell carcinoma, and esophageal cancer. Conversely, cruciferous vegetables are predominantly associated with colorectal, renal, gynecological, and prostate cancer in the American population.</p><p><strong>Conclusion: </strong>This study highlights the complex link between cruciferous vegetables and cancer, influenced by factors such as cancer type, region, intake level, and follow-up duration.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142351130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early-Life Gut Microbiota: A Possible Link Between Maternal Exposure to Non-Nutritive Sweeteners and Metabolic Syndrome in Offspring. 生命早期的肠道微生物群:母体接触非营养性甜味剂与后代代谢综合征之间的可能联系。
IF 5.9 2区 医学
Nutrition reviews Pub Date : 2024-09-30 DOI: 10.1093/nutrit/nuae140
Xiaoxiao Yin, Yujie Shi, Tongtong Sheng, Chenbo Ji
{"title":"Early-Life Gut Microbiota: A Possible Link Between Maternal Exposure to Non-Nutritive Sweeteners and Metabolic Syndrome in Offspring.","authors":"Xiaoxiao Yin, Yujie Shi, Tongtong Sheng, Chenbo Ji","doi":"10.1093/nutrit/nuae140","DOIUrl":"https://doi.org/10.1093/nutrit/nuae140","url":null,"abstract":"<p><p>Metabolic syndrome (MetS) is recognized as a group of metabolic abnormalities, characterized by clustered interconnected traits that elevate the risks of obesity, cardiovascular and atherosclerotic diseases, hyperlipidemia, and type 2 diabetes mellitus. Non-nutritive sweeteners (NNS) are commonly consumed by those with imbalanced calorie intake, especially in the perinatal period. In the past, accumulating evidence showed the transgenerational and mediated roles of human microbiota in the development of early-life MetS. Maternal exposure to NNS has been recognized as a risk factor for filial metabolic disturbance through various mechanisms, among which gut microbiota and derived metabolites function as nodes linking NNS and MetS in early life. Despite the widespread consumption of NNS, there remain growing concerns about their transgenerational impact on metabolic health. There is growing evidence of NNS being implicated in the development of metabolic abnormalities. Intricate complexities exist and a comprehensive understanding of how the gut microbiota interacts with mechanisms related to maternal NNS intake and disrupts metabolic homeostasis of offspring is critical to realize its full potential in preventing early-life MetS. This review aims to elucidate the effects of early-life gut microbiota and links to maternal NNS exposure and imbalanced offspring metabolic homeostasis and discusses potential perspectives and challenges, which may provide enlightenment and understanding into optimal perinatal nutritional management.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142351115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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