Nutrition reviews最新文献

{"title":"Effects of intermittent dieting with break periods on body composition and metabolic adaptation: a systematic review and meta-analysis.","authors":"Eric Tsz-Chun Poon, Jaclyn Hei Tsang, Fenghua Sun, Chen Zheng, Stephen Heung-Sang Wong","doi":"10.1093/nutrit/nuad168","DOIUrl":"10.1093/nutrit/nuad168","url":null,"abstract":"<p><strong>Context: </strong>Intermittent dieting incorporated with break periods (INT-B) has recently been promoted as an alternative dietary approach for optimal weight management.</p><p><strong>Objective: </strong>This study assessed the effectiveness of INT-B compared with that of conventional continuous energy restriction (CER) for improving body composition and attenuating metabolic adaptation.</p><p><strong>Data sources: </strong>A systematic search was conducted on 6 databases using all available records until July 2023.</p><p><strong>Data extraction: </strong>The extracted data included the lead author, year of publication, population characteristics, intervention protocols, duration, and adherence.</p><p><strong>Data analysis: </strong>Random-effects meta-analyses were conducted for within-group and between-group comparisons of anthropometric and metabolic outcomes. Subgroup moderator analysis was performed for the types of INT-B, intervention duration, and population characteristics.</p><p><strong>Results: </strong>Of the 1469 records, 12 randomized trials (with 881 participants) were included. Within-group analyses demonstrated significant improvements in body mass, fat mass, body mass index, body fat percentage, and waist circumference following both INT-B and CER, with no significant group differences. However, resting metabolic rate (RMR) was significantly reduced following CER only. The compensatory reduction in RMR was significantly smaller following INT-B compared with CER, suggesting a lesser degree of metabolic adaptation. INT-B had a more significant effect on RMR retention in individuals with overweight/obesity compared with resistance-trained individuals.</p><p><strong>Conclusion: </strong>This review provides up-to-date evidence for INT-B as a viable dietary strategy to improve body composition and attenuate metabolic adaptation.</p><p><strong>Systematic review registration: </strong>PROSPERO registration no. CRD42023448959.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":"59-71"},"PeriodicalIF":5.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139403883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Plant-Based Diets on Rheumatoid Arthritis: A Systematic Review.","authors":"Zekiye Zeynep Bostan, Melike Şare Bulut, Buket Özen Ünaldı, Ceren Albayrak Buhurcu, Gamze Akbulut","doi":"10.1093/nutrit/nuae181","DOIUrl":"https://doi.org/10.1093/nutrit/nuae181","url":null,"abstract":"<p><strong>Context: </strong>Rheumatoid arthritis (RA) is an autoimmune disease that leads to chronic inflammation and joint damage. Various plant-based diets are thought to have effects on RA symptoms and disease activity.</p><p><strong>Objective: </strong>Relevant literature on the effect of different types of plant-based diets on RA was reviewed.</p><p><strong>Data sources: </strong>A systematic search was conducted using the Web of Science, PubMed, Scopus, and Cochrane databases and following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.</p><p><strong>Data extraction: </strong>Articles on observational and interventional human studies carried out in the adult population and published in English between February 2013 and April 2023 were eligible for inclusion. Articles reporting on studies performed in populations under 18 years of age, with unclear methods and results, or for which the full text was unavailable were excluded. The risk of bias in the selected studies was assessed using the Joanna Briggs Institute checklists.</p><p><strong>Data analysis: </strong>Of 547 screened articles, 15 were included, comprising 4 cross-sectional, 2 cohort, and 9 randomized controlled trials. These studies examined the effects of various diets, including the Mediterranean, low-fat high-carbohydrate, anti-inflammatory, and vegan, on RA. Results indicate adherence to plant-based diets generally reduced disease severity and improved dietary intake, physical activity, body weight, and key clinical markers such as the Disease Activity Score-28, Visual Analog Scale score, Health Assessment Questionnaire Disability Index, erythrocyte sedimentation rate, and C-reactive protein level in patients with in RA.</p><p><strong>Conclusions: </strong>Most of the studies suggested the Mediterranean diet may positively affect the severity of RA. However, the included studies show heterogeneity. Therefore, more randomized controlled studies are needed in this area to increase understanding of the effect of diet on RA and facilitate the implementation of strategies to prevent RA.</p><p><strong>Systematic review registration: </strong>PROSPERO registration no. CRD42023420577.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142952155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Prebiotics and Probiotics on Symptoms of Depression and Anxiety in Clinically Diagnosed Samples: Systematic Review and Meta-analysis of Randomized Controlled Trials.","authors":"Afrida Asad, Megan Kirk, Sufen Zhu, Xue Dong, Min Gao","doi":"10.1093/nutrit/nuae177","DOIUrl":"https://doi.org/10.1093/nutrit/nuae177","url":null,"abstract":"<p><strong>Context: </strong>The use of prebiotics and probiotics as a treatment for psychiatric conditions has gained interest due to their potential to modulate the gut-brain axis. This review aims to assess the effectiveness of these interventions in reducing symptoms of depression and anxiety in psychiatric populations.</p><p><strong>Objective: </strong>The aim was to comprehensively review and appraise the effectiveness of prebiotic, probiotic, and synbiotic interventions in reducing clinical depression and anxiety symptoms.</p><p><strong>Data sources: </strong>Systematic searches were conducted across Embase, Medline, PsycINFO, CINAHL, Cochrane Library, and Science Citation Index from database inception to May 22, 2023.</p><p><strong>Data extraction: </strong>Randomized controlled trials investigating prebiotic, probiotic, or synbiotic interventions for treating clinical depression or anxiety symptoms in clinical samples were included. Data were extracted on study characteristics, intervention details, and outcome measures. The Cochrane Collaboration Tool was used to assess the risk of bias.</p><p><strong>Data analysis: </strong>The standardized mean difference (SMD) was calculated using Hedge's g as the metric of effect size. A random-effects model was applied to estimate pooled effect sizes with 95% CIs. Subgroup analyses were performed based on study characteristics, methodological factors, and intervention types. Sensitivity analyses excluded studies with a high risk of bias.</p><p><strong>Results: </strong>Twenty-three RCTs involving 1401 patients met the inclusion criteria, with 20 trials providing sufficient data for meta-analysis. Of these, 18 trials investigated probiotics for depression, 9 trials assessed probiotics for anxiety, and 3 trials examined prebiotics for depression. Probiotics demonstrated a significant reduction in depression symptoms (SMD: -0.96; 95% CI: -1.31, -0.61) and a moderate reduction in anxiety symptoms (SMD: -0.59; 95% CI: -0.98, -0.19). Prebiotics did not show a significant effect on depression (SMD: -0.28; 95% CI: -0.61, 0.04). High heterogeneity was observed across studies, and subgroup analyses indicated that study duration and probiotic formulations contributed to the variation in effect sizes.</p><p><strong>Conclusion: </strong>Probiotics showed substantial reductions in depression symptoms and moderate reductions in anxiety symptoms. Prebiotics showed a nonsignificant trend toward reducing depression. An adjunctive mental health treatment approach that diagnoses, monitors, and treats the gut microbiome alongside traditional pharmacological treatment holds promise for clinical practice.</p><p><strong>Systematic review registration: </strong>PROSPERO registration no. CRD42023424136.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Balancing Tradition and Nutrition: Jamu in Menstrual Cycle-Based Dietary Guidance.","authors":"Riza Amalia","doi":"10.1093/nutrit/nuae199","DOIUrl":"https://doi.org/10.1093/nutrit/nuae199","url":null,"abstract":"","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conscious Nutrition to Improve Survival Prognosis of Donor Kidney Recipients: A Narrative Review.","authors":"Nargiz Zulkhash, Nasrulla Shanazarov, Saule Kissikova, Duman Turebekov, Elnara Ismagulova","doi":"10.1093/nutrit/nuae204","DOIUrl":"https://doi.org/10.1093/nutrit/nuae204","url":null,"abstract":"<p><p>Kidney transplantation is the optimal treatment for end-stage chronic kidney disease, increasing survival rates and improving quality of life. Diet affects patient weight and well-being, can trigger certain diseases, and influences post-surgery outcomes. The purpose of the study was to investigate dietary strategies in patients with chronic kidney disease, in early and long-term donor kidney recipients, and to formulate specific nutritional recommendations. For this purpose, a narrative review of the available information in both the Republic of Kazakhstan and the world's scientific literature over the last 10 years was carried out. The following evidence-based resources were used: Scopus, PubMed, Embase, Cochrane Library, and Web of Knowledge. The study provides the latest statistical data on kidney transplantation and risk factors, and a comparative analysis between countries. Existing data on basic nutrition and the possibility of using it after transplantation are examined in detail. In addition, the recommendations for daily intake of salt, potassium, sodium, vitamin D, and calcium were analyzed. The energy value of the diet and its association with overweight, obesity, and the development of diabetes mellitus were studied. Using DASH (Dietary Approaches to Stop Hypertension) and low-protein diets as examples, the potential risks and their applicability for this patient category are analyzed. The article's materials and conclusions can serve as a training manual for nephrologists, therapists, and surgeons.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship Between Hepatic Iron Concentration and Glycemic Metabolism, Prediabetes, and Type 2 Diabetes: A Systematic Review.","authors":"Indre Kirkutyte, Gladys Oluyemisi Latunde-Dada","doi":"10.1093/nutrit/nuae197","DOIUrl":"https://doi.org/10.1093/nutrit/nuae197","url":null,"abstract":"<p><strong>Context: </strong>Emerging research has suggested a potential link between high iron levels, indicated by serum ferritin levels, and the development of type 2 diabetes (T2D). However, the role of hepatic iron concentration (HIC) on T2D development and progression is not well understood.</p><p><strong>Objectives: </strong>This study aims to systematically review the literature on HIC and/or the degree of hepatic iron overload (HIO) in individuals with prediabetes and/or diagnosed T2D, and to analyze associations between HIC and markers of glucose metabolism.</p><p><strong>Data sources: </strong>The databases Medline, PubMed, Embase, CINAHL, and Web of Knowledge were searched for studies published in English from 1999 to March 2024. This review followed the Preferred Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist.</p><p><strong>Data extraction: </strong>Data were extracted following the established eligibility criteria. Study characteristics and biomarkers related to prediabetes, T2D, and HIO were extracted. The risk of bias was analyzed using the Newcastle-Ottawa Scale. Data were stratified by the exposure and analyzed in subgroups according to the outcome. Data regarding the HIC values in controls, individuals with prediabetes, and individuals with T2D and the association estimates between HIC or HIO and markers of glycemic metabolism, prediabetes, or T2D were extracted.</p><p><strong>Data analysis: </strong>A total of 12 studies were identified, and data from 4110 individuals were analyzed. HIO was not consistently observed in prediabetic/T2D populations; however, elevated HIC was frequently observed in prediabetic and T2D individuals, and was associated with the disruption of certain glycemic markers in some cases.</p><p><strong>Conclusion: </strong>The extent of iron overload, as indicated by hepatic iron load, varied among the prediabetic and T2D populations studied. Further research is needed to understand the distribution and regulation of iron in T2D pathology.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142896275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diet-Gut Microbiota Relations: Critical Appraisal of Evidence From Studies Using Metagenomics.","authors":"Mrunalini Lotankar, Noora Houttu, Kati Mokkala, Kirsi Laitinen","doi":"10.1093/nutrit/nuae192","DOIUrl":"https://doi.org/10.1093/nutrit/nuae192","url":null,"abstract":"<p><p>Diet may influence the gut microbiota and subsequently affect the host's health. Recent developments in methods analyzing the composition and function of the gut microbiota allow a deeper understanding of diet-gut microbiota relationships. A state-of-the-art methodology, shotgun metagenomics sequencing, offers a higher taxonomic resolution of the gut microbiota at the bacterial species and strain levels, and more accurate information regarding the functional potential of gut microbiota. Here, the available evidence on the relationship between diet and gut microbiota was critically reviewed, focusing on results emerging from recent metagenomics sequencing studies applied in randomized controlled trials and observational studies. The PubMed and Embase databases were used to search publications between January 2011 and September 2023. Thus far, the number of studies is limited, and the study designs and methods utilized have been variable. Nevertheless, the cumulative evidence from interventions relates to dietary fiber as a modifier of bacterial species, such as Anaerostipes hadrus and Faecalibacterium prausnitzii. Furthermore, observational studies have detected associations between different dietary patterns and food groups with certain microbial species. Utilization of metagenomics sequencing is becoming more common and will undoubtedly provide further insights into diet-gut microbiota relationships at the species level as well as their functional pathways in the near future. For reproducible results and to draw reliable conclusions across various studies on diet-gut microbiota relationships, there is a need for harmonization of the study designs and standardized ways of reporting.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142882489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Health Education Interventions in Enhancing Iron-Folic Acid Supplement Utilization Among Pregnant Women: Systematic Review and Meta-analysis.","authors":"Jira Wakoya Feyisa, Judy Yuen-Man Siu, Xue Bai","doi":"10.1093/nutrit/nuae196","DOIUrl":"https://doi.org/10.1093/nutrit/nuae196","url":null,"abstract":"<p><strong>Context: </strong>During pregnancy, the underutilization of iron-folic acid supplements (IFAS) remains a considerable maternal and child health issue. Hence, health education intervention trials were conducted following the recommendation of the World Health Organization and epidemiological studies to enhance the utilization level of the supplements during pregnancy.</p><p><strong>Objective: </strong>The objective of this meta-analysis was to evaluate the effectiveness of health education interventions in enhancing IFAS utilization during pregnancy.</p><p><strong>Data sources: </strong>A thorough search was conducted across PubMed, EMBASE, Scopus, CINAHL, Web of Science, Medline, the Cochrane Library, and Google Scholar from August 28 until October 31, 2023.</p><p><strong>Data extraction: </strong>This study incorporated randomized and quasi-experimental studies that examined the effectiveness of health education interventions in enhancing IFAS utilization during pregnancy.</p><p><strong>Data analysis: </strong>Comprehensive Meta-Analysis, version 4, which includes the prediction interval, was used for the analysis.</p><p><strong>Results: </strong>In this meta-analysis and systematic review, 21 articles comprising 6643 pregnant women from different countries were included. The random-effects model was applied to determine the pooled standardized differences in means (0.786; 95% CI: 0.551, 1.021). The prediction interval shows the range of true standardized differences in means (95% CI: -0.168, 1.740), which indicates the variations in the true effect size of health education interventions in enhancing IFAS utilization during pregnancy.</p><p><strong>Conclusion: </strong>In addition to pooled effect size, another significant advantage of this meta-analysis is conducting the prediction interval to determine the range of the true effect size, which ranges from -0.168 to 1.740 across the groups of different pregnant women, indicating variability in the effectiveness of the interventions in enhancing IFAS utilization during pregnancy. This might occur because most of the primary studies in this meta-analysis were conducted at healthcare facilities and mostly focused on anemic pregnant women attending antenatal care, which did not control for sociocultural determinants. Therefore, future researchers should consider these limitations.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142882494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adherence and Retention in Early or Late Time-Restricted Eating: A Narrative Review of Randomized Controlled Trials.","authors":"Yi Lin, Armin Ezzati, Christian McLaren, Rola S Zeidan, Stephen D Anton","doi":"10.1093/nutrit/nuae195","DOIUrl":"https://doi.org/10.1093/nutrit/nuae195","url":null,"abstract":"<p><p>Time-restricted eating (TRE) is a form of intermittent fasting that involves reducing the time-period in which food is typically consumed daily. While TRE is known to induce health benefits, particularly for adults with obesity, there is currently debate about whether the time of day in which food is consumed also contributes to the health benefits of TRE. Early TRE (eTRE) and late TRE (lTRE) are subtypes of TRE that involve consuming food and caloric beverages either in the early or later part of the day. A growing body of literature indicates that eTRE may offer additional health benefits compared with lTRE. An important and unanswered question, however, is whether most adults can adhere to this type of eating pattern and whether adherence and retention differ between eTRE and lTRE. This narrative review compared adherence and retention in studies that implemented either eTRE or lTRE in adults for 8 weeks or longer. Five databases were searched, and 10 studies met our eligibility criteria. The key finding was that participants had high and comparable levels of adherence and retention in both eTRE and lTRE interventions. Specifically, the mean adherence rate was 81.4% for eTRE and 82.3% for lTRE, while the mean retention rate was 81% for eTRE and 85.8% for lTRE in eligible studies. Thus, the findings support the feasibility of both approaches. The lowest adherence and retention rates occurred in studies in which either eTRE or lTRE regimens were combined with other dietary interventions. Notably, the duration of the eating window did not seem to negatively affect adherence and retention rates for either eTRE or lTRE. More research is warranted to determine the influence of other factors, such as age and study location, on adherence to and retention of both eTRE and lTRE interventions.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Vitamin A Deficiency on Iron Metabolism and Anemia: A Historical Perspective and Research Advances.","authors":"Luis A Mejia, John W Erdman","doi":"10.1093/nutrit/nuae183","DOIUrl":"https://doi.org/10.1093/nutrit/nuae183","url":null,"abstract":"<p><p>Vitamin A deficiency (VAD) and iron deficiency anemia coexist around the world, particularly in children and women of reproductive age in low- and middle-income countries. Within this scenario, there is a known interaction between vitamin A and iron, and it has been postulated that lack of vitamin A impairs iron metabolism, leading to vitamin A deficiency anemia (VADA). Current animal, epidemiological, and clinical studies support this notion. The objective of this study was to review the current literature on proposed metabolic mechanisms regarding how VAD modulates iron metabolism leading to anemia. To attain this objective, a literature search was conducted of research publications in the related field, without date restriction, using PubMed, Scopus, Google Scholar, and the University of Illinois's reference system. The data support the essentiality of vitamin A for normal erythropoiesis. It indicates that, in VAD, iron mobilization is impaired, and that this mineral accumulates in the liver and spleen, making it less available for erythropoiesis. A triggering factor for the development of VADA seems to be inflammation and systemic infection, which release cytokines that upregulate the production of hepcidin by the liver. VAD may also increase hepcidin directly without the involvement of inflammation or infection. The elevated hepcidin, in turn, lowers circulating iron and sequesters iron in storage depots, downregulating erythropoietin, leading to inefficient erythropoiesis, decreased hemoglobin (Hb) production, and (subsequently) anemia. VAD may also impact the expression of iron regulatory protein 2 (IRP2), and thus affect intracellular iron metabolism gene expression. VADA is not due to iron deficiency, but to a redistribution of iron in the body. Understanding the mechanism of VADA will assist in designing more effective strategies for combating anemia worldwide.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}