Inter Collegas最新文献

{"title":"FORENSIC MEDICAL ASSESSMENT OF MORPHOLOGICAL CHANGES AT DIFFERENT POSTMORTEM INTERVAL","authors":"E. Grygorian, V. Olkhovsky, M. Gubin, V. Shishkin","doi":"10.35339/ic.8.3.177-181","DOIUrl":"https://doi.org/10.35339/ic.8.3.177-181","url":null,"abstract":"Purpose: The postmortem interval (PMI) evaluation is one of priorities while performing a forensic medical examination of corpse. To date, there is lack of information of morphological postmortem changes of some internal organs. Considering the persistent need to develop the method for a precise assessment of PMI, postmortem changes in these potentially informative organs were evaluated. The aim of study was to analyze morphological postmortem changes in prostate and uterus.\u0000\u0000Materials and Methods: histological samples of 40 prostate tissues and 40 uterus (n=80) from corpses of deceased aged 18-75 years. Only cases with known time of death were included to study, the time of death was taken from police reports. Exclusion criteria were cases of violent death, cases of death with massive blood loss, tumors of studied internal organs, cases when diagnosis was not made by a forensic medical examiner. The PMI of studied cases ranged from 1 to 6 days. Histological slides were made with a staining by hematoxylin and eosin, x200 magnification, using Olympus ВХ41 and Olympus ВХ46 microscopes, Olympus SC50 camera. Postmortem morphological changes were evaluated by a calculation of blank spaces percentage in microscopical structures using a JS-based program. Connection between PMI and morphological changes was calculated by the Spearman’s rank correlation.\u0000\u0000Results: the average percentage of blank spaces in uterus tissues was smaller than in prostate tissues (1,99 and 9,65 relatively). The slower growing of blank spaces was in uterus. In prostate samples, a notable increase of blank spaces was observed between 48 and 72 hours after the death. After this period, the increase slowed down and then an increase was observed again between 120 and 144 hours after the death. In uterus samples, a slight acceleration observed between 72 and 120 hours after the death and then slowing down between 120 and 144 hours after the death. Blank spaces in evaluated histological slides were increasing directly proportional to the PMI, a statistically significant interconnection was defined (p < 0.05).\u0000\u0000Conclusions: The morphological postmortem changes in prostate and uterus were developing at certain time frames. Blank spaces percentage, in studied histological slides, were increasing directly proportional to the PMI increase, a statistically significant interconnection was defined. Therefore, the results of study show the possibility of the evaluation of a postmortem time interval by assessing such morphological changes in these organs, which could be used in forensic medical cases.","PeriodicalId":194632,"journal":{"name":"Inter Collegas","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129012060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive impairments in patients with treatment resistant epilepsy and complex rehabilitation","authors":"V. Korostiy, I. Blazhina","doi":"10.35339/IC.8.2.123-129","DOIUrl":"https://doi.org/10.35339/IC.8.2.123-129","url":null,"abstract":"Background. The study of features of comorbid pathology in patients with epilepsy is of particular interest due to the high prevalence of this pathology and a significant impact on the quality of life of patients and their social adaptation.\u0000\u0000Aim. The aim of the research was to detect versatile cognitive impairments and affective disorders in epilepsy, and to study the results of cognitive training and psychoeducation.\u0000\u0000Materials and methods. The theoretical analysis of modern scientific researches in the field of cognitive and affective impairments during epilepsy was carried out. We studied the features of clinical and psychopathological manifestations in patients, suffering from epilepsy. The study covered 146patients (85 men and 61 women) who were in inpatient care. The following psychodiagnostic techniques were used: the MOCA test, the Toronto Cognitive Assessment (TorCA), the MiniMult test, the Münsterberg test, the quality of life scale, the Hamilton scale of depression and anxiety.\u0000\u0000Results. This publication offers the results of a study of cognitive and affective disorders the quality of life in patients who suffer from epilepsy and the results of online cognitive training and psychoeducation. We found cognitive decline in 88% of patients with epilepsy and improvement of cognitive functions by methods of non-pharmacological correction.\u0000\u0000Conclusions. Affective and cognitive disorders significantly affects the quality of life of patients, their ability to work and socialization. The conducted research showed that compared to the control group of healthy persons, patients with epilepsy showed improvement in their cognitive decline, anxiety and depressive disorders. Cognitive online training appeared to be effective for the patients with epilepsy.","PeriodicalId":194632,"journal":{"name":"Inter Collegas","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117037767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contribution of adipoq genetic polymorphism to the formation and course of comorbidity of non-alcoholic fatty liver disease and renoparinchemal arterial hypertension","authors":"O. Babak, K. Prosolenko, G. Panchenko, A. Shalimova, K. Lapshyna","doi":"10.35339/IC.8.2.100-105","DOIUrl":"https://doi.org/10.35339/IC.8.2.100-105","url":null,"abstract":"Introduction. Nowadays nonalcoholic fatty liver disease (NAFLD) consider as multisystem disease that is primarily associated with components of the metabolic syndrome and is associated with cardiovascular and renal impairment. The comorbidity of NAFLD with renoparenchymal arterial hypertension (RPAH) has not been sufficiently studied.\u0000\u0000The purpose of the study was to investigate the influence of G276T genetic polymorphism of ADIPOQ on the severity of metabolic disorders, inflammation, liver, artery and kidney damage in the comorbidity of NAFLD and RPAH.\u0000\u0000Materials and methods. The study included 87 patients with comorbidity of NAFLD and RPAH, grade 2. The mean age of patients was 50.78 ± 9.35 years. The vast majority of patients were overweight or obese. The control group was composed of 20 healthy volunteers. Parameters of carbohydrate and lipid metabolism, liver and kidney’s function, adiponectin, fetuin-A, cytokeratin-18, pro-inflammatory cytokines levels were investigated. For diagnostic of non-alcoholic steatosis and indication parameters of arteries, an ultrasound method was used.\u0000\u0000Results. It was found that the T allele was detected in 62 (35.6%) patients of the main group, which was significantly (p<0,05) different from the control group (22.5%). In the presence of patients with comorbidity NAFLD and RPAH G/T and T/T genotypes, carbohydrate metabolism disorders are more pronounced than in the G/G genotype. Thus, index HOMA in this group was 4.52 ± 0.87, which was significantly higher than patients with G/G genotype - 3.77 ± 0.53 (p <0.01).The G276T polymorphism of the ADIPOQ is not associated with markers of liver and kidney damage in patients with NAFLD + RPAH. The presence of G/T and T/T genotypes in patients with comorbidity of NAFLD and RPAH is associated with an increase in interleukin-6 and fetuin-A compared to the G/G genotype. Patients with comorbidity of NAFLD + RPAH and with the T allele of the polymorphic marker G276T of the ADIPOQ gene are more likely to have impaired endothelium-dependent vasodilation, indicating more significant vascular reactivity disorders - 7.72 ± 1.25% for the genotype G/G, and 7.00 ± 1.10% for the genotype G/T (p <0,01).\u0000\u0000Conclusions. The presence of the T allele of the polymorphic marker G276T of the ADIPOQ is associated with the development of comorbidity of NAFLD and RPAH.","PeriodicalId":194632,"journal":{"name":"Inter Collegas","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130240075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P.І. Shatilov as a public actor, scientist, fighter with epidemic diseases: to the centenary of death","authors":"H. Demochko","doi":"10.35339/IC.8.2.69-73","DOIUrl":"https://doi.org/10.35339/IC.8.2.69-73","url":null,"abstract":"Prerequisites. The relevance of the study is caused by the fact that the personality of P. Shatilov does not have a sufficient scientific reflection in the literature from the standpoint and with the use of methods of studying medical local lore. In particular, historical research methods are neglected, however, they can be used to study the work of P. Shatilov in Kharkov in more detail during the epidemics that engulfed the city in 1919-1921. Today, when the whole world suffers from coronavirus infection, it is extremely important to give an example of medical struggle in emergencies, the victories of P. Shatilov not only as a physician but also as a citizen, because such examples instill responsibility to society. \u0000\u0000Task was to provide an updated biographical study of P. Shatilov for the centenary of his death, taking into account the methods of historical research, which had not previously been used in works of this kind. After all, medical personnel require a wider use of methods than previously represented biographical studies on the figure of P. Shatilov. To reproduce the biography of a scientist on a historical background, highlighting not only personal data, but also depicting the era in which the scientist lived and worked. \u0000\u0000Materials and methods. The results of similar studies have indicated that it is necessary to rely on conceptually important general scientific epistemological principles: historicism, objectivity, a combination of both logic and historicity, systematicity. The same methods were used in this study. The methodological basis of this type of research is a specific group of approaches and methods that are used for systematic analysis of the general historical process and medical personalia as an integral part of historical and medical knowledge. The biographical approach, thanks to which the historical reality is considered in time and space, widely covers the problem in a large historical context is a leading one. Phenomenological and paradigmatic approaches provide the necessary scientific tools to reproduce the atmosphere of the time period, reconstruct the preconditions for the formation of worldviews of P. Shatilov, clarify the sources of influence on personality development, the formation of views and beliefs of the scientist, generalization of views and beliefs and his impact on the development of medical science. The high share of this innovative and traditional form of research is provided upon the condition of following the principle of historicism, objectivity of coverage of facts, adequacy in the use of all sources of information, as well as avoiding idealization of the provisions and ideas of the past, giving them a dogmatic status. \u0000\u0000Results. As a result of a comprehensive study, a medical personalia of P. Shatilov was created, which is based on the application of a comprehensive methodological approach. This is what distinguishes this study from previously created ones and provides an example to researcher","PeriodicalId":194632,"journal":{"name":"Inter Collegas","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133293964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Forensic medical examinattion of living persons in cases of injury of the organs of external respiration","authors":"V. Olkhovsky, M. Gubin, E. Grygorian","doi":"10.35339/IC.8.2.95-99","DOIUrl":"https://doi.org/10.35339/IC.8.2.95-99","url":null,"abstract":"Backrgound. Trauma of external respiratory organs in victims is often a reason for the referral to forensic medical examination by law enforcement.\u0000\u0000Purpose of this work was to analyze the peculiarities of formation forensic medical expert conclusion, based on the results of determining the gravity of bodily injuries in victims with closed trauma of the organs external respiration, depending on their morphological and clinical characteristics and gravity, to find the ways to unify expert assessment.\u0000\u0000Subjects and Methods. 183 conclusions of forensic medical examination in the Kharkiv regional expert institution, on the cases of a closed blunt trauma of the organs of external respiration, were analyzed.\u0000\u0000Results. According to the mechanism of bodily injuries, in 171,1 (93,4 %) cases there was an impact of blunt solid objects on the neck and chest, in 11 (6 %) cases there was a compression of the neck by hands or other blunt solid objects, in 1 (0,5 %) case – a compression of the neck by hands and a loop. At the given trauma, modern experts’ approaches to an assessment of bodily injuries were defined. Grievous bodily injuries were defined in 17 (9,3 %) cases of trauma, with the emergence of life-threatening events such as acute respiratory failure, traumatic shock, mechanical asphyxia. Moderate bodily injuries were determined by experts in the 151 (82,5 %) cases, mostly injuries from fractures of ribs and cartilage of the larynx, at absence danger to life. Light bodily injuries were determined by experts in 15 (8,2 %) cases of mostly laryngeal injuries, complicated by its post-traumatic inflammation. The absence of unified scientific and methodological approach for the objective assessment of injuries of the external respiratory system organs has been defined.\u0000\u0000Conclusions. When conducting a forensic medical assessment of such injuries, there are cases of both underestimation and overestimation of the gravity of bodily injuries. According to the results of the performed investigation, further ways to unify morphological and clinical approaches at forensic-medical assessment of these bodily injuries were defined.","PeriodicalId":194632,"journal":{"name":"Inter Collegas","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114789736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Calcium-phosphorus relationships in the combined course of stable ischemic heart disease in patients with obesity","authors":"L. Pasieshvili, K. Ivanová, A. Andrusha, T. Viun, A. Marchenko","doi":"10.35339/IC.8.2.106-110","DOIUrl":"https://doi.org/10.35339/IC.8.2.106-110","url":null,"abstract":"The purpose of the study was to optimize the diagnosis and prediction of the development of structural and functional disorders of bone tissue in patients with SCHD and obesity. Thus, lipid profile analysis showed a clinically significant increase in total cholesterol and triglycerides in patients with SCHD. Serum bone mineral status did not exceed normal values, but serum total calcium levels were significantly higher in patients with SCHD and obesity compared to other groups. The indicators of calcium-phosphorus metabolism in the daily urine of patients with SCHD were significantly higher. When conducting densitometric studies in patients with SCHD with normal weight, osteopenic conditions were diagnosed more often than in patients with overweight and obesity. That is, the comorbid course of SCHD and obesity is a high risk of osteodeficiency, which is confirmed by early changes in calcium-phosphorus metabolism.","PeriodicalId":194632,"journal":{"name":"Inter Collegas","volume":"1987 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125477455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Students' experience of stress with different framework conditions and different origins","authors":"Irina Bоckelmann, Håvard R. Karlsen, S. Darius, B. Thielmann","doi":"10.35339/IC.8.2.74-86","DOIUrl":"https://doi.org/10.35339/IC.8.2.74-86","url":null,"abstract":"Background. Students are exposed to numerous stress factors. The large number of demands and high strain can lead to a higher drop-out rate. For this reason, the aim of the study is to examine and comparing the experience of stress among German and international students during their studies under adaptation to generally stressful conditions. The international students performed a complete study program in Germany.\u0000\u0000Methods. Data from 194 students (41.8% women, 58.2% men) were evaluated. The average age of the participants was 23.0±3.44 years. Our sample consisted of 80 international students. The questionnaire on strains during the study (and at the workplace) was used. We registered the frequency and the intensity of the stress factors in everyday study life. We factor analysed the 34 stress items, which gave five main stress factors. We then looked at the differences between German and international students on these factors, while adjusting for generally stressful conditions.\u0000\u0000Results. The most important stressors were unfavourable working hours, incompatibility of tasks, climate, excessive demands, high responsibility, lack of information, social isolation, emotional strain and financial problems. The stressors differed in 17 out of 34 stressors in the groups of students of different origin. The international students experienced more physical and psychosocial strain and they experienced resources less often than German students did, but if they felt them, it was more intense.\u0000\u0000Conclusions. Strains during studies and their individual demands vary. German and international students have different perceptions of stress during study programs. There is a need for health promotion and prevention programs, which should be integrated during study.","PeriodicalId":194632,"journal":{"name":"Inter Collegas","volume":"12 2‐3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132359310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Results of treatment of patients with midfacial fractures","authors":"A. Khudyk, S. Grigorov","doi":"10.35339/IC.8.2.115-122","DOIUrl":"https://doi.org/10.35339/IC.8.2.115-122","url":null,"abstract":"Background. Fractures of the bones of the facial skeleton, in particular the midface area, are one of the most frequent reasons for patients to apply to maxillofacial inpatient care, not only in Ukraine but also abroad. Along with more modern treatment technologies (osteosynthesis using titanium miniplates and minigrid for fixation bone fragments), methods of repositioning of fragments with subsequent tamponade of the maxillary sinus with iodoform tampon and without tamponade and fixation of fragments are used. A certain group of patients is treated conservatively, which is associated with their reluctance to undergo surgery, minimal displacement of fragments or minimal cosmetic and functional impairments.\u0000\u0000The purpose of the study. Comparative evaluation of the results of treatment of patients with fractures of the midface area by repositioning the fragments of the zygomatic-orbital complex without fixating the fragments and their subsequent fixation by tamponade of the maxillary sinus with iodoform tampon.\u0000\u0000Object and methods of research. The comparison was made of the results of treatment of 70 patients with fractures of the midface area, among which 13 patients were treated by the method of repositioning fragments of the zygomatic-orbital complex (ZOC) without fixation and without maxillary sinus tamponade, 29 patients underwent repositioning of ZOC fragments with subsequent fixation of fragments with iodoform tampon – the tamponade of the maxillary sinus was performed on the affected side. For comparison, the results of conservative treatment of 28 patients with fractures of the midface area were used.\u0000\u0000Results. It was found that the reliable (χ2=11.43; p<0.05) majority of patients (64%) sought treatment within 0-3 days after injury. 83-89% of patients who underwent repositioning of the fragments had fresh small-fragment fractures. The reliable (χ2=11.43; p<0.05) majority of them simultaneously had 3-4 sites of bone fractures of the midfacearea, hemosinus of varying degrees and paresthesia in the infraorbital area. In the majority of patients who underwent repositioning of bone fragments with and without tamponade (85% and 93%, respectively), the final displacements ranged from 3.1 to 6 mm. In patients treated conservatively, in most cases (93%) the displacements were greater than 3.1 mm, which remained after treatment.\u0000\u0000Conclusion. In the majority of patients treated with the studied methods, in the long term, the displacement of bone fragments remained, which had functional and cosmetic consequences. In all studied groups, a certain cosmetic effect was achieved over time, as evidenced by a reliable (χ2=160.9; p=0.00000) decrease in the indicator by the visual analogue scale .","PeriodicalId":194632,"journal":{"name":"Inter Collegas","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133529488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pro-atherogenic lipid profile in pulmonary tuberculosis patients with concurrent insulin resistance","authors":"O. Shvets, O. Shevchenko, Z. Piskur, Hanna Stepanenko, O. Pohorielova","doi":"10.35339/IC.8.2.111-114","DOIUrl":"https://doi.org/10.35339/IC.8.2.111-114","url":null,"abstract":"Background. The problem of studying lipid metabolism in patients with tuberculosis is of interest to scientists around the world. The purpose of the study - to investigate lipid profile in pulmonary tuberculosis patients with concurrent insulin resistance.\u0000\u0000Materials and methods. Forty-one patients with pulmonary tuberculosis were examined. Insulin resistance index (HOMA-IR), total cholesterol level (TC), triglycerides (TG) level, high density lipoprotein (HDL) cholesterol, low density lipoprotein (LDL) cholesterol, very-low-density lipoprotein (VLDL) cholesterol and atherogenic index (AI) were measured.\u0000\u0000Results. Group 1 - 26 patients with tuberculosis and insulin resistance (HOMA-IR ˃ 2.7); Group 2 – 15 patients with tuberculosis without insulin resistance (HOMA-IR ˂ 2.7). Group 1 patients had severe course of TB with fever, severe fatigue and weakness, profuse sweating, weight loss, cough and shortness of breath. Median TC indices differed at significant level (p = 0.012): group 1 - 4.82 mmol/l, group 2 - 4.25 mmol/l. TG level was higher in group 1 patients - 1.32 mmol/l than in group 2 patients - 1.28 mmol/l. LDL cholesterol values were higher in group 1 patients - 3.2 mmol/l vs 2.5 mmol/l in group 2. The AI was higher in group1 (p = 0.005): 3.9 units against 2.8 units in group 2 patients.\u0000\u0000Conclusions. Insulin resistance in pulmonary tuberculosis patients was associated with severe course of the disease, severe clinical manifestations and impaired external respiration. Pro-atherogenic disorders of lipid metabolism in pulmonary tuberculosis patients with concurrent insulin resistance can be considered as the degree of endogenous intoxication.","PeriodicalId":194632,"journal":{"name":"Inter Collegas","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115492444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathophysiological aspects as the object of the treatment tactics in acute pancreatitis (review)","authors":"Kryvoruchko Ia, A. Drozdova, N. Goncharova","doi":"10.35339/IC.8.2.87-94","DOIUrl":"https://doi.org/10.35339/IC.8.2.87-94","url":null,"abstract":"The review presents a modern view on the features of the course and treatment of acute pancreatitis, based on a cascade of pathophysiological mechanisms of this disease. A number of concepts of development and course of acute pancreatitis on the basis of randomized prospective and retrospective researches devoted to this problem are considered. Attention is paid to the mechanisms of development of organ failure in acute pancreatitis. In accordance with the above, the main positions of treatment measures for acute pancreatitis, which are based on the principles of tactics \"step-up approach\" were highlighted. Among them, attention is focused on the features of the conservative treatment program, minimally invasive surgical interventions, as well as the management of the postoperative period of patients. Minimally invasive surgical interventions perform the main tasks of surgical treatment in acute pancreatitis, but significantly reduce surgical trauma compared to \"open\" methods. Adequate management of the postoperative period of patients is carried out through the implementation of protocols \"fast-track surgery\".","PeriodicalId":194632,"journal":{"name":"Inter Collegas","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133276836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}