Inter Collegas最新文献

{"title":"INFLUENCE OF AGE AND MORPHOLOGICAL FEATURES ON THE CLINICAL MANIFESTATIONS AND TREATMENT EFFICACY OF HEMANGIOMAS IN CHILDREN","authors":"V. Vivcharuk, V. Davydenko","doi":"10.35339/IC.8.1.22-29","DOIUrl":"https://doi.org/10.35339/IC.8.1.22-29","url":null,"abstract":"Background. Infantile hemangioma (IH) is a neoplasm that is most common in childhood. Morphologically, hemangiomas are divided into superficial, deep and mixed, focal, segmental, indeterminate and multifocal. The course of IH includes phases of rapid growth followed by slow involution. The degree of involution of hemangioma is variable. Hemangiomas can lead to the appearance of permanent deformities of soft tissues or functional disorders, especially when localized on the face and vital structures. Clinical heterogeneity of hemangiomas creates significant difficulties for physicians in resolving issues of treatment tactics. Specific characteristics of the clinical behavior of hemangiomas of various morphological types can be crucial in the choice of management tactics for such patients. \u0000\u0000Objectives. The aim of the work is to study the effect of different morphological types of hemangioma in children on the effectiveness of treatment of age-related clinical features. \u0000\u0000Subjects and Methods. The study group consisted of 100 children in age from birth to 6 years who have hemangiomas of different morphological types and localizations and did not receive previous treatment. All research participants for hemangioma severity scale (HSS), hemangioma activity scale (HAS), visual analogue scale (VAS) before, during and after treatment were scored. Serum levels sFas/sFasLs before and during treatment evaluated. \u0000\u0000Results. With increasing the child’s age, the indicator as for HAS reliably decreases for all types of hemangiomas. In all types of hemangiomas predominantly an active growth took place. An abortive growth in 10% of patients was noted. For focal hemangiomas, the indicator of sFas decreases with age, and for multifocal hemangiomas it increases. In both cases, there is an increase in the sFasL indicator with increasing age of the child. In our study, in age group before 1 year in the factor structures, “age” factor was considered to be the main one and manifested by a decrease in the activity of hemangioma with an increase in the age of the child. Among children over 1 year age, during the course of treatment, the greatest contribution the “hemangioma severity factor”, the influence of which leads to a decrease in the cosmetic effect of hemangioma treatment against the background of its high severity and an increase in the indicator of apoptosis inhibition of sFas. The influence of the “treatment efficacy” factor leads to a decrease in its cosmetic effect and an increase in the severity of the manifestations of hemangioma against the background of blocking the manifestations of apoptosis. \u0000\u0000Conclusions. When starting treatment of hemangioma in the early stages, the cosmetic effect increases significantly. A decrease in sFasL in the younger age group may indicate a decrease or absence of apoptosis processes, which is clinically expressed by active proliferation. An increase in sFas in the older age group (over a year old) may indicate a blockage of a","PeriodicalId":194632,"journal":{"name":"Inter Collegas","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133643601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ON THE ISSUE OF REPRODUCTIVE LOSSES PREVENTION IN UKRAINE","authors":"T. Alieva, A. Shevchenko","doi":"10.35339/IC.8.1.59-66","DOIUrl":"https://doi.org/10.35339/IC.8.1.59-66","url":null,"abstract":"The aim of the study was to determine the compliance of the existing medical care system in Ukraine for pregnant and married couples planning a pregnancy (its organizational and financial capabilities), the need to reduce the high level of reproductive losses.\u0000\u0000Materials and methods. Methods of statistical and system analysis are used. The national programs of reproductive health, demographic data, data on morbidity (received from the national medical statistics for the period 2017–2018), reports of the national survey “Health Index of Ukraine” (2018), data on appeals for obstetric-gynecological, genetic care (in connection of reproductive losses, fertility) are analyzed. A comparison between the indicators of Ukraine and the Kharkiv region, as well as with other countries, according to the cost of the survey, requests for medical care for the examination of genetic and infectious diseases associated with reproductive losses, was made. The organization of outpatient care for pregnant and married couples who are planning a pregnancy has been analyzed in terms of availability and sources of payment for services.\u0000\u0000Results. The number of Ukrainian women planning their first pregnancy aged 35 and over is increasing. Naturally, the number of genetic pathologies increases. Indicators of infectious pathology remain high. At the same time, women visit less gynecologists and family doctors, which is due to the high cost of the part of medical care that patients have to pay for themselves. Insufficiently developed genetic screening programs for genetic diseases. The professional contacts of physician of various specialties need to be improved. These facts negatively affect the level of reproductive losses, complicate their prevention.\u0000\u0000Conclusions. To reduce reproductive losses, it is necessary to create a national disease monitoring center, increase the availability of obstetric-gynecological and genetic care for the population, increase coverage of genetic screening programs, and give birth to children at the optimal age of 20–34.","PeriodicalId":194632,"journal":{"name":"Inter Collegas","volume":"132 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131406191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE IMPACT OF SMOKING ON THE MORPHOFUNCTIONAL STATE OF PERIODONTAL TISSUES OF YOUNG ORGANISM","authors":"A. Romaniuk, R. Nazaryan, Y. Zakut, T. Popova, V. Gargin","doi":"10.35339/IC.8.1.47-51","DOIUrl":"https://doi.org/10.35339/IC.8.1.47-51","url":null,"abstract":"Background. The interrelation of disorders in periodontal tissues with metabolic changes caused, in particular, by a violation of microcirculation, observed namely in smoking but the fact that the effect of smoking on the condition of periodontal tissues at a young age has been studied less than other risk factors deserves special attention. The aim of our study was to experimentally assess the effect of smoking on the morphofunctional state of periodontal tissues in young animals. \u0000\u0000Materials and methods. Simulation of smoking has been performed with ten-week-old WAG rats using the Boyarchuck chamber. Morphometric studies were performed in the gingival zone which was chosen for morphological interpretation of volumes of specific vascular density in microcirculatory bed, specific density of connective tissue in lamina propria and specific area of tissue with ischemia. The obtained digital data were processed by the methods of variation statistics. \u0000\u0000Results. Simulation of smoking for four weeks in experimental animals leads to pathological changes in the morphofunctional state of the periodontium with reducing vascular density from 19.44±1.97% to 11.03±1.38 %, increasing area of connective tissue from 18.33±2.71% to 26.49±1.24%, spreading area of tissue with ischemia from 1.14±0.70% to 6.35±1.67%. \u0000\u0000Conclusions. Morphofunctional changes in the periodontium with damage to the structure of the epithelial membrane and changes in its permeability, microcirculatory disorders, sclerotic changes are a manifestation of the initial inflammatory and dystrophic processes that can lead to persistent chronic pathology.","PeriodicalId":194632,"journal":{"name":"Inter Collegas","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123489446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 INTERSTITIAL PNEUMONIA (case report)","authors":"T. Ashcheulova, M. Volik","doi":"10.35339/IC.7.4.174-179","DOIUrl":"https://doi.org/10.35339/IC.7.4.174-179","url":null,"abstract":"A clinical case of treatment of a 54-year-old man with several risk factors, including diabetes, obesity, hypertension, with moderate COVID-19 bilateral pneumonia is presented. His clinical symptoms and signs at presentation included combinations of fever, nonproductive cough, and shortness of breath. Initial chest radiograms faid to show any changes, but chest CT revealed ground glass opacities (GGOs) with fuzzy contours, parenchyma damage (27 %). He was treated according to the Guidelines for diagnosis and treatment of COVID-19 cases (the Order of Ministry of Health of Ukraine No. 762). After a 12-day treatment, the damaged area reduced to 5 % with fibrosis.","PeriodicalId":194632,"journal":{"name":"Inter Collegas","volume":"109 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121879117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resources-based Strategies for Health Promotion of Students With Different General Conditions and Different Origins","authors":"I. Böckelmann, S. Darius, B. Thielmann","doi":"10.21203/rs.3.rs-71583/v1","DOIUrl":"https://doi.org/10.21203/rs.3.rs-71583/v1","url":null,"abstract":"\u0000 Background: The aim of this study is to investigate the study-/work-related behavior and experience patterns of students, taking into account their origins as well as the stressful general conditions. Methods: A total of 194 students (41.8% women, 58.2% men, 58.7% German and 41.3% foreign students) were evaluated to their strains during the study and study-/work-related Behavior and Experience Patterns (AVEM). Four potentially stressful conditions were taken into account.Results: For only 14% of foreign students, but 45% of German students risk patterns for work-related behavior and experience were found. Study-/work-related behaviour and experience patterns depend on the origin of the students. Resources during study were significantly higher among students of German origin. Conclusions: A study-related strengthening of resources is necessary, which can be viewed as a competitive advantage when choosing a study location.","PeriodicalId":194632,"journal":{"name":"Inter Collegas","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128782321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The EVALUATION OF 3-YEARS COURSE OF SUBLINGUAL IMMUNOTHERAPY WITH EXTRACTS OF CAT EPITHELIUM IN PRE-SCHOOL CHILDREN","authors":"O. Sharikadze","doi":"10.35339/IC.6.4.216-220","DOIUrl":"https://doi.org/10.35339/IC.6.4.216-220","url":null,"abstract":"EVALUATION OF 3-YEARS COURSE OF SUBLINGUAL IMMUNOTHERAPY WITH EXTRACTS OF CAT EPITHELIUM IN PRE-SCHOOL CHILDREN. \u0000Sharikadze O. \u0000The article presents the results of a 3-year course of sublingual allergen immunotherapy with a lyophilized extract of cat epidermal allergens in preschool children with allergic rhinitis, rhino-conjunctivitis and bronchial asthma. New possibilities of component diagnostics were found, and in particular, the definition of the major Fel d 1 molecule as a direct indication for the start of therapy and use to assess the achievement of tolerance to the causative allergen. It was found that a 3-year course of sublingual allergen immunotherapy with lyophilized epidermal cat allergens for children with allergic rhinitis and/or bronchial asthma was characterized by a significant improvement in the clinical symptoms of the disease and a decrease in the level of Fel d1. A comparative analysis of the results of observing children with SLIT and without therapy proved that SLIT in children with allergic pathology associated with sensitization to cat epidermal allergens reduces the number of exacerbations and prevents the development of symptoms of bronchial asthma in preschool children. In addition, once again, high safety allergen immunotherapy efficacy in children has been proven. \u0000Keywords: preschool children, sublingual allergen immunotherapy, prevention, asthma, major allergens Fel d 1. \u0000  \u0000Абстракт. \u0000ОЦІНКА 3-РІЧНОГО КУРСУ СУБЛІНГВАЛЬНОЇ ІМУНОТЕРАПІЇ ЕКСТРАКТАМИКОТЯЧОГО ЕПІТЕЛІЮ У ДІТЕЙ ДОШКІЛЬНОГО ВІКУ. \u0000Шарікадзе О. \u0000У статті представлені результати 3-х річного курсу сублингвальной алерген-імунотерапіїліофілізованим екстрактом епідермальних алергенів кота у дітей дошкільного віку з алергічнимринітом, рино-кон'юнктивітом і бронхіальну астму. Виявлено нові можливості компонентної діагностики і зокрема, визначення мажорній молекули Fel d 1 як прямого показання до початку терапії і використання для оцінки досягнення толерантності до причинному алергену. Встановлено, що проведення 3-х річного курсу сублингвальной алерген-імунотерапії ліофілізованими епідермальними алергенами кота дітям з алергічним ринітом та / або бронхіальною астмою характеризувалося достовірним поліпшенням клінічних симптомів захворювання і зменшенням рівня Fel d1. Порівняльний аналіз результатів спостереження дітей на тлі злити і без терапії довів, що злитися у дітей з алергічною патологією, пов'язаною з сенсибілізацією до епідермальних алергенів кота зменшує кількість загострень і попереджає розвиток симптомів бронхіальної астми у дітей дошкільного віку. Крім того, в черговий раз була доведена висока безпека алерген-імунотерапія ефективність у дітей. \u0000 Ключові слова: діти дошкільного віку, сублінгвальна алерген-імунотерапія, профілактика, бронхіальна астма, мажорні алергени Fel d 1. \u0000  \u0000Абстракт. \u0000ОЦЕНКА 3-ЛЕТНЕГО КУРСА СУБЛИНГВАЛЬНОЙ ИММУНОТЕРАПИИ С ИСПОЛЬЗОВАНИЕМ ЭКСТРАКТОВ КОШАЧЬЕГО ЭПИТЕЛИЯ У ДЕТЕЙ ДОШКОЛЬНОГО ВОЗРАСТА. \u0000Шарикадзе Е. \u0000В статье представле","PeriodicalId":194632,"journal":{"name":"Inter Collegas","volume":"110 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128007866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE CURRENT STATE OF THE PROBLEM OF PERINATAL PSYCHOSOMATIC DISORDERS IN PREGNANT WOMEN.","authors":"N. Scherbina, L. V. Potapova, I. Scherbina, O. Lipko, Olga V Mertsalova","doi":"10.35339/IC.6.4.226-231","DOIUrl":"https://doi.org/10.35339/IC.6.4.226-231","url":null,"abstract":"\u0000 \u0000 \u0000THE CURRENT STATE OF THE PROBLEM OF PERINATAL PSYCHOSOMATIC DISORDERS IN PREGNANT WOMEN Scherbina N., Potapova L., Scherbina I., Lipko O., Mertsalova O. \u0000 \u0000 \u0000 \u0000Objective: to study the characteristics of the psychosomatic state of women during pregnancy using the Edinburgh Postpartum Depression Scale (EPDS). Materials and Methods: sixty pregnant women in the III trimester of pregnancy were tested using the EPDS questionnaire, a 10-point self-assessment scale that covers the general symptoms of depression. To determine the internal consistency and reliability of this scale, the Cronbach alpha indicator, a statistical indicator that allows evaluation of whether the features included in the questionnaire measure the same thing (high internal agreement), or different things (low internal agreement), was calculated. Results: Subjectively, all pregnant women noted  simplicity, unambiguity and clear wording of the questions, which indicated good acceptability of this questionnaire for the use in the complex of standard monitoring of pregnant women in an antenatal clinic. The Cronbach alpha coefficient was 0.775, which corresponds to a sufficient degree of consistency of the internal elements of the scale. Screening for depressive disorders using EPDS during pregnancy revealed psychosomatic problems of the perinatal period. Data obtained using this scale demonstrate high rates of depressive manifestations in pregnant women. Psychopathological disorders were detected in 40% of women, while in 23% the symptoms of the current \"major\" depression were identified. The frequency of development of depressive symptoms increases significantly in the presence of a high obstetric risk, characteristic of the current pregnancy (threat of premature birth, hypertensive disorders during pregnancy, intrauterine infection of the fetus, retardation of the fetus development), as well as compromised obstetric and gynecological history. EPDS can be used as a reliable diagnostic tool to prevent pregnancy-related adverse outcomes. Conclusions: identifying the risk factors of pregnancy, screening and examining psychosomatic symptoms with EPDS, and timely referral for psychiatric care are key issues for reducing the risk among women with psychosomatic disorders during pregnancy and the postpartum period. \u0000Keywords: pregnancy, psychosomatic disorders, Edinburgh postpartum depression scale. \u0000  \u0000Абстракт. \u0000СУЧАСНИЙ СТАН ПРОБЛЕМИ ПЕРИНАТАЛЬНИХ ПСИХОСОМАТИЧНИХ РОЗЛАДІВ У ВАГІТНИХ. \u0000Щербина М., Потапова Л., Щербина I., Ліпко О., Мерцалова О. \u0000Мета дослідження: вивчити особливості психосоматичного стану жінок під час вагітності з використанням Единбурзької шкали післяпологової депресії (EPDS). Матеріали і методи: проведено тестування за опитувальником EPDS 60 вагітних жінок в III триместрі вагітності. EPDS є шкалою самооцінки, складається з 10 пунктів охоплює загальну симптоматику депресії. Для визначення внутрішньої узгодженості і надійності зазначеної шкали розраховувався показник ","PeriodicalId":194632,"journal":{"name":"Inter Collegas","volume":"87 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123321502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CYTOKERATIN-18 FRAGMENTS FOR PREDICTING STEATHOHEPATITIS IN PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE","authors":"O. Babak, N. Zhelezniakova, V. Molodan, V. Prosolenko, K. Lapshyna, M. Vizir","doi":"10.35339/IC.6.3.137-142","DOIUrl":"https://doi.org/10.35339/IC.6.3.137-142","url":null,"abstract":"Abstract \u0000CYTOKERATIN-18 FRAGMENTS FOR PREDICTING STEATOHEPATITIS IN PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE \u0000Babak O., Zhelezniakova N., Molodan V., Prosolenko K., Lapshyna K., Vizir M. \u0000The aim of the study was to investigate metabolic parameters, cytokeratin 18 (CK-18) levels in blood plasma and the state of the liver parenchyma of patients with non-alcoholic fatty liver disease (NAFLD) in non-alcoholic steatohepatitis (NASH) stage. Materials and methods: Fasting serum CK-18 was measured in 30 NASH patients (mean age (49.3±3.6). The control group consisted of 20 practically healthy volunteers. The diagnosis of NADH was established on the basis of clinical, biochemical and instrumental data. In addition to basic laboratory tests and ultrasonographic examination, the Fibromax test (Biopredective, France) was performed. Results: In patients with NAFLD, the lipid profile showed a tendency to hyper- and dyslipidemia. The obtained data showed a significant increase in the parameters of enzymatic activity of the liver, the average level of aspartate aminotransferase (AST) exceeded the control group 2.5 times, the alanine aminotransferase (ALT) – 2.9 times, respectively (˂ 0.05). In NAFLD in NASH stage CK-18 levels in blood plasma were significantly increased, exceeded the results of the control group 3 and more times, and allowed to establish NASH in patients of the main group. Conclusions: Increased levels of CK-18 in NASH patients as well as its association with atherogenic dyslipidemia and increasing of liver enzymatic activity were revealed. The obtained data showed the possibility of using biomarker for non‑invasive diagnostics of NASH and represent the prospect of further research. \u0000Key words: nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, noninvasive diagnosis, cytokeratin-18. \u0000  \u0000Резюме. \u0000ФРАГМЕНТИ ЦИТОКЕРАТИНУ-18 ДЛЯ ПРОГНОЗУВАННЯ СТЕАТОГЕПАТИТУ У ПАЦІЄНТІВ З НЕАЛКОГОЛЬНОЮ ЖИРОВОЮ ХВОРОБОЮ ПЕЧІНКИ \u0000Бабак О.Я., Железнякова Н.М., Молодан В.І., Просоленко К.О., Лапшина К.А., Візір М.О. \u0000Мета дослідження: вивчити метаболічні показники, рівні цитокератину 18 (СК-18) у плазмі крові та стан паренхіми печінки у хворих на неалкогольну жирову хворобу печінки (НАЖХП) y стадії неалкогольного стеатогепатиту (НАСГ). Матеріали і методи: Обстежено 30 хворих з НАЖХП в стадії НАСГ, у віці від 30 до 60 років (середній вік (49.3 ± 3.6) років). Групу контролю склали 20 практично здорових добровольців. Діагноз НАЖХП був встановлений на підставі клініко-біохімічних та інструментальних даних. Всім пацієнтам, окрім основних лабораторних і ультрасонографічних досліджень, було проведено тест Fibromax (Biopredective, Франція). Визначення цитокератину-18 (СК-18) в плазмі крові проводилось імуноферментним методом з використанням наборів ELISA. Результати дослідження: У пацієнтів з НАЖХП ліпідний профіль показав тенденцію до гіпер- і дисліпідемії. Отримані дані свідчили про достовірне підвищення показників ферментативної активності печінки, середні","PeriodicalId":194632,"journal":{"name":"Inter Collegas","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115255543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"INFLUENCE OF HORMONAL DISORDERS ON ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH ARTERIAL HYPERTENSION AND COMORBIDE ENDOCRINOPATHIES","authors":"O. Bilovol, V. Nemtsova, I. Ilchenko, V. Zlatkina","doi":"10.35339/IC.6.3.132-136","DOIUrl":"https://doi.org/10.35339/IC.6.3.132-136","url":null,"abstract":"Abstract. \u0000INFLUENCE OF HORMONAL DISORDERS ON ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH ARTERIAL HYPERTENSION AND COMORBIDE ENDOCRINOPATHIES \u0000Bilovol O.M., Nemtsova V.D., Ilchenko I.A., Zlatkina V.V. \u0000Purpose: to investigate the effect of hormonal changes on endothelial dysfunction (ED) in patients with a comorbid course of hypertension (H), type 2 diabetes mellitus (T2DM) and subclinical hypothyroidism (SHT). Methods: 183 patients with  H stage II were divided into 3 groups: Group 1 (n=50) - with isolated H (comparison group); Group 2 (n=63) - with a combined course of H and T2DM; Group 3 (n=70) - with comorbidity of H, T2DM and SHT. Blood pressure levels, carbohydrate, lipid and thyroid metabolism, plasma insulin concentration, insulin resistance (IR) the HOMA-IR index, vascular endothelial growth factor (VEGF-A) plasma levels were investigated. Results: Dyslipidemia was more pronounced in group 2 than in group 1. The addition of SHT was accompanied by a tendency to increase all the atherogenic lipids. IR was observed in all patients groups and was significantly higher than in control group (p<0.05). Significant increase of VEGF-A levels in all patients groups in comparison with the control (p<0.05) was found. In group 2 VEGF-A was lower than in group 1, which is probably due to the protective effect of metformin. Analysis  of the influence of thyroid dysfunction degree on ED revealed significant increase of VEGF-A levels in TSH>6.0 μMU/ml subgroup (352.55±17.64 pg/ml vs 461.74±20.13 pg/ml (p<0.05)). Conclusion: Hormonal disorders contribute to aggravation of endothelial dysfunction in patients with hypertension and comorbid endocrinopathies - type 2 diabetes mellitus and subclinical hypothyroidism. Even minor decrease in thyroid function lead to the progression of endothelial dysfunction. \u0000Key words: hypertension, type 2 diabetes mellitus, subclinical hypothyroidism, endothelial dysfunction \u0000  \u0000Резюме. \u0000ВПЛИВ ГОРМОНАЛЬНИХ ПОРУШЕНЬ НА ЕНДОТЕЛІАЛЬНУ ДИСФУНКЦІЮ УПАЦІЄНТІВ З АРТЕРІАЛЬНОЮ ГІПЕРТЕНЗІЄЮ ТА КОМОРБІДНИМИ ЕНДОКРИНОПАТІЯМИ \u0000Біловол О.М., Немцова В.Д., Ільченко І.А., Златкіна В.В. \u0000Мета: дослідити вплив гормональних змін на ендотеліальну дисфункцію (ЕД) у пацієнтів з коморбідним перебігом артеріальної гіпертензії (АГ), цукрового діабету 2 типу (ЦД2Т) тасубклінічного гіпотиреозу (СГТ). Матеріали та методи: 183 пацієнта з АГ II стадії були розділені на 3 групи: 1-а група (n=50) - з ізольованою АГ (група порівняння); Група 2 (n=63) - з поєднаним перебігом АГ та ЦД2Т; Група 3 (n 70) – з комбінованим перебігом АГ, ЦД2Т і СГТ. Вивчали рівні артеріального тиску, показники вуглеводного, ліпідного і тиреоїдного обміну, концентрацію інсуліну в плазмі, індекс інсулінорезистентності (ІР) - HOMA-IR, рівні васкулоендотеліального фактора росту (VEGF-A) в плазмі. Результати. Ступінь дисліпідемії у 2-й групі була більш вираженою, ніж в 1-й. Приєднання СГТ супроводжувалося тенденцією до збільшення всіх атерогенних фракцій ліпідів. ІР спостерігалася у всіх г","PeriodicalId":194632,"journal":{"name":"Inter Collegas","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130095800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RISK FACTORS OF DEVELOPMENT OF HALLUCINATORY-PARANOIDAL DISORDERS IN PATIENTS WITH DEMENTIA OF A MIXED GENESIS","authors":"K. Shevchenko-Bitensky","doi":"10.35339/IC.6.3.174-178","DOIUrl":"https://doi.org/10.35339/IC.6.3.174-178","url":null,"abstract":"Abstract \u0000Seventy-two patients with Alzheimer's disease (AD) with late onset and vascular brain disease, dementia with hallucinatory-paranoid symptoms (the main group) were examined. The control group included 61 patients with AD with late onset and vascular disease of the brain without hallucinatory-paranoid symptoms. The risk factors for the development of hallucinatory-paranoid disorders in patients with mixed dementia were determined. These factors included: female gender; age of 78.6 ± 7.3 years old; hereditary burden of personality disorders; genetic predisposition for cognitive disorders; the presence of a neuropathic constitution in childhood; a retardation of a psychophysical development in childhood; low levels of academic performance; absence of family; secondary and secondary speciaized education; a physical type of a job; acute psychogenic factors associated with the worsening of financial conditions, conflicts in the family, and divorce.","PeriodicalId":194632,"journal":{"name":"Inter Collegas","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124054831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}