adipoq基因多态性对非酒精性脂肪肝和肾化学性动脉高血压合并症的形成和病程的贡献

O. Babak, K. Prosolenko, G. Panchenko, A. Shalimova, K. Lapshyna
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The control group was composed of 20 healthy volunteers. Parameters of carbohydrate and lipid metabolism, liver and kidney’s function, adiponectin, fetuin-A, cytokeratin-18, pro-inflammatory cytokines levels were investigated. For diagnostic of non-alcoholic steatosis and indication parameters of arteries, an ultrasound method was used.\n\nResults. It was found that the T allele was detected in 62 (35.6%) patients of the main group, which was significantly (p<0,05) different from the control group (22.5%). In the presence of patients with comorbidity NAFLD and RPAH G/T and T/T genotypes, carbohydrate metabolism disorders are more pronounced than in the G/G genotype. Thus, index HOMA in this group was 4.52 ± 0.87, which was significantly higher than patients with G/G genotype - 3.77 ± 0.53 (p <0.01).The G276T polymorphism of the ADIPOQ is not associated with markers of liver and kidney damage in patients with NAFLD + RPAH. 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摘要

介绍。目前,非酒精性脂肪性肝病(NAFLD)被认为是一种多系统疾病,主要与代谢综合征成分相关,并与心血管和肾脏损害相关。NAFLD与肾实质性动脉高血压(RPAH)的合并症尚未得到充分的研究。本研究旨在探讨ADIPOQ G276T基因多态性对NAFLD和RPAH合并症中代谢紊乱、炎症、肝脏、动脉和肾脏损害严重程度的影响。材料和方法。该研究纳入87例伴有NAFLD和rpa2级合并症的患者。患者平均年龄50.78±9.35岁。绝大多数患者超重或肥胖。对照组由20名健康志愿者组成。观察各组糖脂代谢、肝肾功能、脂联素、胎儿素- a、细胞角蛋白-18、促炎因子水平。应用超声诊断非酒精性脂肪变性及动脉指征参数。结果发现,主组62例(35.6%)患者检出T等位基因,与对照组(22.5%)差异有统计学意义(p< 0.05)。在合并NAFLD和rpag /T和T/T基因型的患者中,碳水化合物代谢紊乱比G/G基因型患者更为明显。因此,本组患者HOMA指数为4.52±0.87,显著高于G/G基因型患者的3.77±0.53 (p <0.01)。在NAFLD + RPAH患者中,ADIPOQ的G276T多态性与肝肾损害标志物无关。与G/G基因型相比,伴有NAFLD和RPAH合并症的患者中G/T和T/T基因型的存在与白细胞介素-6和胎儿素- a的增加有关。合并NAFLD + RPAH并伴有ADIPOQ基因多态性标记物G276T等位基因T的患者更容易出现内皮依赖性血管舒张功能受损,血管反应性障碍更明显,基因型G/G为7.72±1.25%,基因型G/T为7.00±1.10% (p < 0.01)。ADIPOQ多态性标记物G276T的T等位基因的存在与NAFLD和RPAH共病的发生有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Contribution of adipoq genetic polymorphism to the formation and course of comorbidity of non-alcoholic fatty liver disease and renoparinchemal arterial hypertension
Introduction. Nowadays nonalcoholic fatty liver disease (NAFLD) consider as multisystem disease that is primarily associated with components of the metabolic syndrome and is associated with cardiovascular and renal impairment. The comorbidity of NAFLD with renoparenchymal arterial hypertension (RPAH) has not been sufficiently studied. The purpose of the study was to investigate the influence of G276T genetic polymorphism of ADIPOQ on the severity of metabolic disorders, inflammation, liver, artery and kidney damage in the comorbidity of NAFLD and RPAH. Materials and methods. The study included 87 patients with comorbidity of NAFLD and RPAH, grade 2. The mean age of patients was 50.78 ± 9.35 years. The vast majority of patients were overweight or obese. The control group was composed of 20 healthy volunteers. Parameters of carbohydrate and lipid metabolism, liver and kidney’s function, adiponectin, fetuin-A, cytokeratin-18, pro-inflammatory cytokines levels were investigated. For diagnostic of non-alcoholic steatosis and indication parameters of arteries, an ultrasound method was used. Results. It was found that the T allele was detected in 62 (35.6%) patients of the main group, which was significantly (p<0,05) different from the control group (22.5%). In the presence of patients with comorbidity NAFLD and RPAH G/T and T/T genotypes, carbohydrate metabolism disorders are more pronounced than in the G/G genotype. Thus, index HOMA in this group was 4.52 ± 0.87, which was significantly higher than patients with G/G genotype - 3.77 ± 0.53 (p <0.01).The G276T polymorphism of the ADIPOQ is not associated with markers of liver and kidney damage in patients with NAFLD + RPAH. The presence of G/T and T/T genotypes in patients with comorbidity of NAFLD and RPAH is associated with an increase in interleukin-6 and fetuin-A compared to the G/G genotype. Patients with comorbidity of NAFLD + RPAH and with the T allele of the polymorphic marker G276T of the ADIPOQ gene are more likely to have impaired endothelium-dependent vasodilation, indicating more significant vascular reactivity disorders - 7.72 ± 1.25% for the genotype G/G, and 7.00 ± 1.10% for the genotype G/T (p <0,01). Conclusions. The presence of the T allele of the polymorphic marker G276T of the ADIPOQ is associated with the development of comorbidity of NAFLD and RPAH.
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