Occupational and Environmental Medicine最新文献

{"title":"Using social media to highlight inhaled occupational exposures as a cause of lung disease.","authors":"David Fishwick, Sara De Matteis, Martie van Tongeren, Emma Thompson, Dick J J Heederik, Saskia Weldam, Ewelina Szmytke, Jessica Denning, Andrew David Curran, Pippa Powell","doi":"10.1136/oemed-2025-110401","DOIUrl":"10.1136/oemed-2025-110401","url":null,"abstract":"<p><strong>Introduction: </strong>The risks to lung health from workplace hazards remain incompletely understood and may still be overlooked by workers, employers and healthcare professionals. We used an online tool to collect European population-based data relating to workplace exposures, training and lung health.</p><p><strong>Methods: </strong>A targeted industry-specific digital tool, enquiring about the link between respiratory symptoms and work, was made accessible online over a 24-month period.</p><p><strong>Results: </strong>22 393 individuals (mean age 43.6 years) responded; 55.7% were female, 46.7% completed in English, 19.9% in Portuguese, 17.8% in French, 10.5% in Dutch and 5% in German. 47% reported nasal symptoms, 42% cough, 21% chest tightness and 20% wheeze. 8412 (37.6%) reported at least one work-related symptom. The use of workplace training (11%) and guidance (17%) to prevent respiratory ill health was uncommon. 980 (5.9%) had changed their job because it had affected their breathing. Increasing age (OR 1.02 per year age increase), completion language (English (OR 0.66), French (OR 0.39)), workplace (bakery (OR 1.64), mine (OR 1.91), sports centre (OR 3.03) and farm (OR 1.77)) and workplace training (OR 0.71) were significantly associated with this outcome. These workers also had more work-related symptoms (p<0.001) and complained of more wheeze (p<0.001) and nasal symptoms (p<0.001). 919 (5.6%) workers with a more likely diagnosis of occupational asthma were more female, had less workplace guidance and training and had co-workers with health complaints.</p><p><strong>Conclusion: </strong>This tool has reached real-world working populations and these findings identify the need for further awareness raising, education and social media interventions.</p>","PeriodicalId":19459,"journal":{"name":"Occupational and Environmental Medicine","volume":" ","pages":"217-222"},"PeriodicalIF":3.2,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13422065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148218893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occupational standing, walking and forward bending during pregnancy and the risk of miscarriage: a Danish nationwide, register-based, cohort study.","authors":"Hannah Nørtoft Frankel, Camilla Sandal Sejbaek, Esben Meulengracht Flachs, Mette Korshøj, Sandra Soegaard Toettenborg, Jens Peter Ellekilde Bonde, Laura Deen, Jonathan Aavang Petersen, Christina Bach Lund, Luise Mølenberg Begtrup","doi":"10.1136/oemed-2025-110712","DOIUrl":"10.1136/oemed-2025-110712","url":null,"abstract":"<p><strong>Objective: </strong>We aimed to investigate the association between occupational standing, walking and forward bending during pregnancy and the risk of miscarriage.</p><p><strong>Methods: </strong>This register-based study examined all labour-active pregnant women in Denmark between 2004 and 2018, comprising 803 829 pregnancies among 475 312 women. Occupational exposure to standing, walking and forward bending ≥30° was assessed with a quantitative, pregnancy-specific job exposure matrix, based on the woman's occupational code in the occupational and industry register, at the year of pregnancy start. Information on miscarriage was retrieved from the Danish National Patient Register (DNPR). Statistics Denmark, the Danish Medical Birth Registry and the DNPR provided information on potential confounders. Absence data, sourced from the Danish Register for Evaluation and Marginalisation (DREAM), were assessed as an effect modifier. We estimated adjusted hazard ratios (aHRs) using Cox regression.</p><p><strong>Results: </strong>All three exposures were associated with increased hazards for miscarriage. The aHR for miscarriage was 1.03 (95% CI: 1.02 to 1.04) per additional hour of occupational <i>standing</i>, 1.18 (95% CI: 1.15 to 1.22) per additional hour of occupational <i>walking</i> and 1.36 (95% CI: 1.30 to 1.41) per additional hour of occupational <i>forward bending</i>. The aHR was more pronounced among women with absence from work the preceding week than among those without. Post hoc quartile analyses indicated a consistent exposure-response relationship for forward bending, while the associations for standing and walking decreased at the highest quartile.</p><p><strong>Conclusions: </strong>We found an elevated risk of miscarriage associated with all three occupational exposures. Replication in comparable populations incorporating smoking status and other health information is needed to validate these associations.</p>","PeriodicalId":19459,"journal":{"name":"Occupational and Environmental Medicine","volume":" ","pages":"181-187"},"PeriodicalIF":3.2,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148278297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of the EILA application on smoking cessation among hospital workers: a randomised controlled trial.","authors":"Erik Schneider, Wiebke Wanner, Mareike Lüthgen, Dominik Edward Pawlak, Henrike Alexandra Faesser, Kai Mortensen, Daniel Drömann, Tobias Jagomast, Klaas F Franzen","doi":"10.1136/oemed-2025-110157","DOIUrl":"10.1136/oemed-2025-110157","url":null,"abstract":"<p><strong>Objectives: </strong>Smoking remains a major preventable cause of lung and cardiovascular disease. This randomised controlled trial evaluated EILA, a mobile application using artificial intelligence, for promoting smoking cessation among hospital workers.</p><p><strong>Methods: </strong>A randomised controlled trial was conducted. Hospital workers (n=43) were recruited from a German university hospital from May 2022 to March 2023. Inclusion criteria comprised age ≥18, Fagerström score ≥3 or 10 cigarettes per day, ownership of a suitable smartphone, motivation to quit smoking and no addiction to other psychoactive substances. Participants were randomised by sealed envelopes to EILA intervention (n=25) or a wait-list control (n=18) receiving a primary care-style intervention, with crossover after 3 months. The primary outcome was the cessation rate. Secondary outcomes comprised nicotine dependence, mental health and cardiovascular risk, all measured using validated questionnaires.</p><p><strong>Results: </strong>At the 6-month follow-up, the relative risk for continued smoking was reduced to 0.91 (n=51, 95% CI 0.7 to 1.2), and nicotine dependence, measured by the Fagerström Test, decreased significantly from 4.41±1.93 to 3.32±2.69 (n=19, p=0.014). PROCAM score for cardiovascular risk was reduced from 35.22±12.47 to 31.9±13.24 (n=36, p=0.008).</p><p><strong>Conclusion: </strong>The digital health application EILA was linked to increased smoking cessation rates, although without achieving statistical significance. Nevertheless, the results indicate reductions in nicotine dependence and cardiovascular risk, supporting EILA as a scalable and flexible intervention for promoting health in hospital workers.</p>","PeriodicalId":19459,"journal":{"name":"Occupational and Environmental Medicine","volume":" ","pages":"210-216"},"PeriodicalIF":3.2,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13422096/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148205695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Under the microscope: formaldehyde exposure in National Health Service pathology departments in the United Kingdom.","authors":"Magdalena Plesa, Richard L Yates","doi":"10.1136/oemed-2025-110545","DOIUrl":"10.1136/oemed-2025-110545","url":null,"abstract":"<p><strong>Objectives: </strong>The US Environmental Protection Agency has determined that formaldehyde presents an 'unreasonable risk of injury to human health'. Occupational inhalation exposure is associated with short- and long-term damage to the respiratory, female reproductive and nervous systems, and is also carcinogenic. The European Union (EU) has recently introduced formaldehyde work exposure limits (WELs) lower (long-term 0.3 ppm; short-term 0.6 ppm) than those currently applied in the UK (long-term 2 ppm; short-term 2 ppm). UK regulation additionally requires exposure to carcinogens to be reduced to <i>as low as is reasonably practicable</i>. We evaluated formaldehyde airborne concentrations in National Health Service (NHS) cell pathology departments to assess the adequacy of exposure controls.</p><p><strong>Methods: </strong>Using the UK Freedom of Information Act (2000), we requested 12 months (2024-2025) of formaldehyde airborne monitoring data collected by cell pathology departments across 122 NHS Trusts in England (n=102), Scotland (n=10), Wales (n=6) and Northern Ireland (n=4). Results were evaluated empirically and using EN 689:2018 statistical methods to assess exposure variability, estimate upper-bound concentrations and determine the likelihood of adequate exposure control when benchmarked against EU WELs.</p><p><strong>Results: </strong>A total of 1 715 516 formaldehyde airborne monitoring results were disclosed by 117 NHS cell pathology departments. Monitoring was infrequent, with 73% of sites measuring formaldehyde airborne concentrations once weekly or less. The EU long-term WEL was exceeded regularly at 70% of sites (95th percentile >0.3 ppm), and the EU short-term WEL was exceeded regularly at 43% of sites (95th percentile >0.6 ppm). The 95th percentile upper tolerance limit (UTL_95,70) exceeded the EU short-term WEL at 68% of sites. Only 11% and 17% of departments demonstrated frequent (once daily or more) formaldehyde airborne monitoring with 95th percentiles below the EU long- and short-term WELs, respectively.</p><p><strong>Conclusions: </strong>Formaldehyde exposure is infrequently monitored and inadequately controlled in NHS cell pathology departments.</p>","PeriodicalId":19459,"journal":{"name":"Occupational and Environmental Medicine","volume":" ","pages":"123-129"},"PeriodicalIF":3.2,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148150724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occupational and environmental risk factors for salivary gland cancer: a systematic literature review.","authors":"Denny Choi, Khayati Patel, Andrew Zarnke, David Boyce-Fappiano, Donald Cole, Sarah McCormick Rhodes","doi":"10.1136/oemed-2025-110485","DOIUrl":"10.1136/oemed-2025-110485","url":null,"abstract":"<p><p>Occupational and environmental risk factors for salivary gland cancer (SGC) are largely unrecognised. This systematic review is the first to characterise the relationship between employment in specific industries or occupations and risk of SGC, as well as exposure to key occupational and environmental hazards.Studies published up to September 2023 were collected from three electronic databases and systematically screened. The Health Assessment Workplace Collaborative programme was used to tag studies based on pre-established inclusion and exclusion criteria. Studies eligible for inclusion (n=24) underwent an in-depth review to extract key study characteristics and findings, including effect estimates and 95% CIs. Studies were evaluated for influence of key biases. To identify priority sectors and hazards for intervention, effect direction plots were created to analyse the number and quality of studies reporting elevated rates of SGC across industry, occupation and exposure groups.24 articles were included for analysis. Exposure misclassification and confounding bias were a common concern across studies. Industry and occupation groups with the strongest relationship to SGC included cleaning services, material handling, food services, rubber/plastics production, engineering and construction/painting. Exposures with the strongest relationship to SGC included silica dust, cement dust, chlorinated solvents, formaldehyde and white spirits.Several occupational exposures were associated with an elevated risk of SGC, whereas environmental evidence was more limited. Additional research involving larger cohorts with quantitative exposure data is needed to further establish relationships between occupational and environmental exposures and often-overlooked rare cancers like SGC.PROSPERO registration number: CRD42023468037.</p>","PeriodicalId":19459,"journal":{"name":"Occupational and Environmental Medicine","volume":" ","pages":"170-180"},"PeriodicalIF":3.2,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13311965/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148176242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between sick leave during pregnancy and after childbirth and future labour force participation: a Dutch cohort study.","authors":"Zayel Z Frijmersum, Eva Van Der Meij, Judith A Huirne, Petra C Bakker, Johannes Anema","doi":"10.1136/oemed-2025-110638","DOIUrl":"10.1136/oemed-2025-110638","url":null,"abstract":"<p><strong>Objectives: </strong>Women's labour force participation often declines after childbirth, but the role of sick leave during pregnancy and after childbirth in sustained employment remains unclear. This study examined: (1) the association between sick leave during pregnancy and/or within 2 years after childbirth and sustained labour force participation, (2) whether sick leave during pregnancy predicts sick leave within 2 years after childbirth, (3) demographic and employment-related factors associated with sick leave length and labour force participation.</p><p><strong>Methods: </strong>Prospective cohort study including 261 171 women in the Netherlands who applied for maternity benefits in 2020 or 2021. A subset also received sick leave benefits during pregnancy or after childbirth. Logistic regression assessed associations between sick leave timing and sustained labour participation. General linear models examined determinants of the total length of sick leave during pregnancy and within 2 years after childbirth.</p><p><strong>Results: </strong>Sick leave during pregnancy was associated with higher odds of sustained labour force participation (OR 1.20, 95% CI 1.17 to 1.23), whereas sick leave within 2 years after childbirth was associated with lower odds (OR 0.65, 95% CI 0.62 to 0.67). Sick leave during pregnancy strongly predicted sick leave within 2 years after childbirth (OR 3.63, 95% CI 3.53 to 3.74). Employment sector, contract type, residential area and age were associated with sick leave length and labour participation.</p><p><strong>Conclusion: </strong>Sick leave within 2 years after childbirth was associated with reduced sustained labour force participation, whereas sick leave during pregnancy was not negatively associated. Employment characteristics were strongly associated with both sick leave patterns and sustained labour force participation.</p>","PeriodicalId":19459,"journal":{"name":"Occupational and Environmental Medicine","volume":" ","pages":"146-153"},"PeriodicalIF":3.2,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13311932/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147974487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalent occupational carcinogenic exposure under the microscope.","authors":"Hans Kromhout, Martie van Tongeren","doi":"10.1136/oemed-2026-111043","DOIUrl":"10.1136/oemed-2026-111043","url":null,"abstract":"","PeriodicalId":19459,"journal":{"name":"Occupational and Environmental Medicine","volume":" ","pages":"121-122"},"PeriodicalIF":3.2,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148211841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between maternal occupational history and autism spectrum disorder diagnosis in offspring in Denmark.","authors":"Aisha S Dickerson, Yisi Liu, Christine Ladd-Acosta, Jing Wang, Diana Schendel, Marc G Weisskopf, M Danielle Fallin, Johnni Hansen","doi":"10.1136/oemed-2026-110912","DOIUrl":"10.1136/oemed-2026-110912","url":null,"abstract":"<p><strong>Objectives: </strong>We investigated associations between maternal occupations and a diagnosis of autism spectrum disorder (ASD) in offspring.</p><p><strong>Methods: </strong>We obtained data for 1702 ASD cases born between 1973 and 2012 from the Danish National Patient Registry and matched each case to up to 100 population based controls based on sex and birth year (n=110 234). Mothers' employment histories were obtained from the Danish Pension Fund Registry. Conditional logistic regression models were used to test associations between occupations held ever, 1 year before conception, during pregnancy and during infancy, adjusting for the mother's age and history of neuropsychiatric disorders, parity and residential location.</p><p><strong>Results: </strong>There were increased odds of having a child with ASD for mothers who were employed before conception up to infancy in ground transportation (adjusted OR (aOR) 1.24, 95% CI 1.08 to 1.42; <i>q</i>=0.036), public administration (aOR 1.20, 95% CI 1.07 to 1.35; <i>q</i>=0.018) and military/defence occupations (aOR 1.59, 95% CI 1.39 to 1.82; <i>q</i><0.001). Associations for judicial occupations and military/defence service were also apparent 1 year before conception and during pregnancy. We observed sex differences, with significant associations in male children for employment in ground transportation and defence occupations.</p><p><strong>Conclusions: </strong>Associations between certain maternal employment categories with high toxicant or psychosocial stress exposure suggest future studies should focus on examining specific toxicant exposures common in those occupations and neurodevelopment in offspring. This is of particular concern for associations seen for occupations held several years before conception.</p>","PeriodicalId":19459,"journal":{"name":"Occupational and Environmental Medicine","volume":" ","pages":"130-137"},"PeriodicalIF":3.2,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13278461/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147931850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lung cancer risk prediction models and asbestos exposure: a validation study on the Western Australia Asbestos Review Program.","authors":"Chellan Kumarasamy, Kim Betts, Richard Norman, Kirsten Bennett, Peter Franklin, Martin Tammemägi, Fraser Brims","doi":"10.1136/oemed-2025-110249","DOIUrl":"10.1136/oemed-2025-110249","url":null,"abstract":"<p><strong>Objectives: </strong>Asbestos exposure raises the lung cancer risk and has supra-additive synergy alongside tobacco exposure. Lung cancer screening (LCS) is effective when high-risk populations are targeted. This study examined the utility of various LCS eligibility and risk prediction models in an asbestos-exposed population.</p><p><strong>Methods: </strong>The Western Australia Asbestos Review Program (ARP) consists of individuals with known exposure to asbestos. All participants underwent annual review with low-dose CT screening. The performance of the Prostate, Lung, Colorectal and Ovarian (PLCO)_m2012, PLCO_m2014 and PLCO_occ models, Liverpool Lung Project V.2 (LLP_v2) and Bach models, together with the United States Preventive Services Task Force (USPSTF)₂₀₂₁ and Australian LCS eligibility criteria were validated on the ARP.</p><p><strong>Results: </strong>The cohort consisted of 2126 participants of which 85.4% were male with a median (IQR) age of 70 (63-75) years old. Former smokers comprised 55.1% (n=1172) and never smokers 36.2% (n=769) of the cohort. Median smoking and cessation duration were 24 years (IQR: 13-72) and 32 years (IQR: 22-41), respectively. Lung cancer was diagnosed in 51 (2.4%) participants.When applying the risk models to the ARP cohort, the area under the curve for all models was modest, ranging from 0.602 to 0.675. All models underestimated risk in this cohort during calibration assessment, with the exception of the LLP V.2, which overestimated risk.</p><p><strong>Conclusions: </strong>In an asbestos exposed population, current LCS eligibility criteria and risk models mostly underestimate the risk of lung cancer, reflecting the need for improved risk prediction models that adequately account for asbestos exposure.</p>","PeriodicalId":19459,"journal":{"name":"Occupational and Environmental Medicine","volume":" ","pages":"154-161"},"PeriodicalIF":3.2,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13311979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148144220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between occupational exposure to chromium (VI) and cancers of the oral cavity, small intestine, pancreas, prostate and urinary bladder: systematic review and meta-analyses.","authors":"Jan-Paul Zock, Kelly J Rijs, Susan Peters, Jelle J Vlaanderen","doi":"10.1136/oemed-2025-110733","DOIUrl":"10.1136/oemed-2025-110733","url":null,"abstract":"<p><p>Hexavalent chromium (Cr(VI)) is a human carcinogen. It is unclear whether Cr(VI) can cause cancer of the small intestine, oral cavity, pancreas, prostate and urinary bladder. We performed a systematic review and meta-analyses of epidemiological studies on occupational exposure to Cr(VI) and incidence and mortality of these cancer sites.A comprehensive review of human studies on Cr(VI) and cancer was performed in Embase and Scopus. 131 potentially relevant epidemiological studies were identified. Study quality was assessed using the Newcastle-Ottawa Scale. 29 publications including 81 observations for meta-analyses were based on cohort or case-control studies with exposure assessment of sufficient quality. Site-specific random-effects meta-analyses were done separately for incidence and mortality. Sensitivity analyses focused on the studies with the highest quality scores.No indications for an association between Cr(VI) exposure and oral or small intestine cancer were found. Incidence of pancreatic cancer was not associated with Cr(VI) exposure (meta-relative risk (RR) 1.04; 95% CI 0.85 to 1.28) while for specific mortality RR was 1.41 (95% CI 0.96 to 2.08) with moderate heterogeneity (I²=41%) and an asymmetric funnel plot (Egger's test; p=0.002). For incidence of prostate cancer meta RR was 1.16 (95% CI 0.99 to 1.37) while the RR for mortality was 1.03 (95% CI 0.84 to 1.25). For bladder cancer, RR was 1.04 (95% CI 0.91 to 1.20) for incidence and 1.76 (95% CI 1.20 to 2.60) for mortality.This comprehensive meta-analysis of epidemiological studies did not provide sufficient evidence that occupational Cr(VI) exposure may cause cancer of the oral cavity, small intestine, pancreas, prostate or the urinary bladder in humans.</p>","PeriodicalId":19459,"journal":{"name":"Occupational and Environmental Medicine","volume":" ","pages":"162-169"},"PeriodicalIF":3.2,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147841186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}