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Health Watch: cancer and mortality update in a 40-year prospective cohort study of Australian petroleum workers. 健康观察:澳大利亚石油工人40年前瞻性队列研究的癌症和死亡率更新。
IF 3.1 2区 医学
Occupational and Environmental Medicine Pub Date : 2026-05-07 DOI: 10.1136/oemed-2025-110739
Elisa Wood, Deborah C Glass, Stella M Gwini, Malcolm R Sim, Stephen Vander Hoorn, Anthony Del Monaco, Karen Walker-Bone
{"title":"Health Watch: cancer and mortality update in a 40-year prospective cohort study of Australian petroleum workers.","authors":"Elisa Wood, Deborah C Glass, Stella M Gwini, Malcolm R Sim, Stephen Vander Hoorn, Anthony Del Monaco, Karen Walker-Bone","doi":"10.1136/oemed-2025-110739","DOIUrl":"https://doi.org/10.1136/oemed-2025-110739","url":null,"abstract":"<p><strong>Objectives: </strong>To report estimates of cancer incidence (1982-2016) and mortality (1980-2020) in the Health Watch cohort after four decades of follow-up.</p><p><strong>Methods: </strong>Health Watch is a prospective cohort study of 18 040 (16 666 men, 1374 women) employees recruited between 1981 and 2000.Personal data were linked to national and state cancer and death registries. Standardised mortality ratios (SMRs) and standardised incidence ratios were calculated using national population rates adjusted for age, sex and calendar period.</p><p><strong>Results: </strong>All-cause mortality was reduced compared with Australian population rates (men: SMR 0.79, 95% CI 0.77 to 0.82; women: SMR 0.70, 95% CI 0.59 to 0.83).</p><p><strong>Conclusions: </strong>Lower mortality likely reflects the healthy worker effect. Persistent excesses of mesothelioma, melanoma and prostate cancer may reflect ongoing occupational risks warranting targeted prevention and surveillance. In particular, melanoma risk underscores the need to minimise both occupational and recreational ultraviolet exposure.</p>","PeriodicalId":19459,"journal":{"name":"Occupational and Environmental Medicine","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147841234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Associations between occupational exposure to chromium (VI) and cancers of the oral cavity, small intestine, pancreas, prostate and urinary bladder: systematic review and meta-analyses. 职业接触铬(VI)与口腔癌、小肠癌、胰腺癌、前列腺癌和膀胱癌之间的关系:系统评价和荟萃分析
IF 3.1 2区 医学
Occupational and Environmental Medicine Pub Date : 2026-05-07 DOI: 10.1136/oemed-2025-110733
Jan-Paul Zock, Kelly J Rijs, Susan Peters, Jelle J Vlaanderen
{"title":"Associations between occupational exposure to chromium (VI) and cancers of the oral cavity, small intestine, pancreas, prostate and urinary bladder: systematic review and meta-analyses.","authors":"Jan-Paul Zock, Kelly J Rijs, Susan Peters, Jelle J Vlaanderen","doi":"10.1136/oemed-2025-110733","DOIUrl":"https://doi.org/10.1136/oemed-2025-110733","url":null,"abstract":"<p><p>Hexavalent chromium (Cr(VI)) is a human carcinogen. It is unclear whether Cr(VI) can cause cancer of the small intestine, oral cavity, pancreas, prostate and urinary bladder. We performed a systematic review and meta-analyses of epidemiological studies on occupational exposure to Cr(VI) and incidence and mortality of these cancer sites.A comprehensive review of human studies on Cr(VI) and cancer was performed in Embase and Scopus. 131 potentially relevant epidemiological studies were identified. Study quality was assessed using the Newcastle-Ottawa Scale. 29 publications including 81 observations for meta-analyses were based on cohort or case-control studies with exposure assessment of sufficient quality. Site-specific random-effects meta-analyses were done separately for incidence and mortality. Sensitivity analyses focused on the studies with the highest quality scores.No indications for an association between Cr(VI) exposure and oral or small intestine cancer were found. Incidence of pancreatic cancer was not associated with Cr(VI) exposure (meta-relative risk (RR) 1.04; 95% CI 0.85 to 1.28) while for specific mortality RR was 1.41 (95% CI 0.96 to 2.08) with moderate heterogeneity (I<sup>2</sup>=41%) and an asymmetric funnel plot (Egger's test; p=0.002). For incidence of prostate cancer meta RR was 1.16 (95% CI 0.99 to 1.37) while the RR for mortality was 1.03 (95% CI 0.84 to 1.25). For bladder cancer, RR was 1.04 (95% CI 0.91 to 1.20) for incidence and 1.76 (95% CI 1.20 to 2.60) for mortality.This comprehensive meta-analysis of epidemiological studies did not provide sufficient evidence that occupational Cr(VI) exposure may cause cancer of the oral cavity, small intestine, pancreas, prostate or the urinary bladder in humans.</p>","PeriodicalId":19459,"journal":{"name":"Occupational and Environmental Medicine","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147841186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lymphoid neoplasms and benzene exposure using a revised classification scheme: systematic review and meta-analysis. 使用修订分类方案的淋巴肿瘤和苯暴露:系统评价和荟萃分析。
IF 3.1 2区 医学
Occupational and Environmental Medicine Pub Date : 2026-05-04 DOI: 10.1136/oemed-2025-110652
Hyun-Wook Park, Youjin Kim, Seung-Yeon Lee, Yeonjae Kim, Wanhyung Lee
{"title":"Lymphoid neoplasms and benzene exposure using a revised classification scheme: systematic review and meta-analysis.","authors":"Hyun-Wook Park, Youjin Kim, Seung-Yeon Lee, Yeonjae Kim, Wanhyung Lee","doi":"10.1136/oemed-2025-110652","DOIUrl":"https://doi.org/10.1136/oemed-2025-110652","url":null,"abstract":"<p><p>Lymphoid neoplasms are a diverse group of cancers derived from lymphocytes, with classification recently updated by the 5th edition of the WHO Classification of Haematolymphoid Tumours (WHO-HAEM5). Benzene, a well-known carcinogen, is widely used in industries and environmental exposures vary; however, its association with specific lymphoid neoplasm subtypes remains unclear due to historical classification challenges. This study aimed to clarify the risk of lymphoid neoplasms related to benzene exposure using the updated WHO-HAEM5 framework.A systematic review and meta-analysis were conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Eligible studies were comparative human studies evaluating benzene exposure and lymphoid neoplasm risk, with sufficient data for risk estimates. Inclusion criteria specified study designs, participants, exposures and outcomes based on clinical diagnoses. Data were independently extracted by multiple reviewers. The main outcome was risk of lymphoid neoplasms and subtypes analysed by random-effects meta-analysis with heterogeneity and bias assessments.From 1488 records, 95 studies met criteria (65 occupational and 30 environmental exposure). Benzene exposure significantly increased overall lymphoid neoplasm risk (RR 1.26; 95% CI 1.18 to 1.35). B-cell neoplasms showed elevated risk (RR 1.26; 95% CI 1.16 to 1.37), including mature B-cell neoplasms, Hodgkin lymphoma and plasma cell neoplasms. T-cell and natural killer cell neoplasm risk was not significantly increased overall. Occupational exposures conferred higher risks with lower heterogeneity than environmental exposures.Benzene exposure is strongly associated with increased risk of lymphoid neoplasms, particularly B-cell subtypes, supported by the refined WHO-HAEM5 classification reducing heterogeneity. This study underscores the importance of biologically informed disease classification and the need for targeted occupational safety and environmental health policies.The review protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO) (Registration ID: CRD420251063844).</p>","PeriodicalId":19459,"journal":{"name":"Occupational and Environmental Medicine","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147841193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cancer, chronic obstructive pulmonary disease and ischaemic heart disease in Ontario, Canada workers exposed to diesel engine exhaust. 癌症,慢性阻塞性肺病和缺血性心脏病在安大略省,加拿大工人暴露于柴油机废气。
IF 3.1 2区 医学
Occupational and Environmental Medicine Pub Date : 2026-04-29 DOI: 10.1136/oemed-2025-110689
Stephanie Ziembicki, Tracy L Kirkham, Victoria H Arrandale, Tanya Navaneelan, Paul A Demers
{"title":"Cancer, chronic obstructive pulmonary disease and ischaemic heart disease in Ontario, Canada workers exposed to diesel engine exhaust.","authors":"Stephanie Ziembicki, Tracy L Kirkham, Victoria H Arrandale, Tanya Navaneelan, Paul A Demers","doi":"10.1136/oemed-2025-110689","DOIUrl":"https://doi.org/10.1136/oemed-2025-110689","url":null,"abstract":"<p><strong>Objective: </strong>This study assesses potential exposure-response relationships between diesel engine exhaust (DEE) and lung and bladder cancers, chronic obstructive pulmonary disease (COPD) and ischaemic heart disease (IHD) in Ontario workers in the Occupational Disease Surveillance System.</p><p><strong>Methods: </strong>Approximately 2.3 million workers were identified through workers' compensation claims (1983-2019) and followed for cancer through linkage with the Ontario Cancer Registry (1964-2019). COPD and IHD cases were identified using hospital discharges (2006-2020), emergency department visits (2006-2020) and physician billing records (1999-2020). Exposure was assessed using the Diesel Exhaust in Canada Job-Exposure Matrix, a semiquantitative job-exposure matrix based on expert assessment and published measurement data. Cox-proportional hazards models were used to estimate HRs and 95% CIs, adjusted for age, birth year and sex by exposure status (exposed/unexposed) and for increasing exposure level (unexposed, low, moderate, high and very high). Trend tests were run using exposure category midpoints (µg/m<sup>3</sup> elemental carbon).</p><p><strong>Results: </strong>Overall, 39 743 incident lung cancer, 12 528 bladder cancer, 77 124 COPD and 302 876 IHD cases were identified. Among exposed cases (all outcomes), the majority (90%) were assigned low exposure. Significant increased risks of lung cancer (HR=1.33, 95% CI 1.29 to 1.37), bladder cancer (HR=1.19, 95% CI 1.13 to 1.26), COPD (HR=1.34, 95% CI 1.31 to 1.37) and IHD (HR=1.15, 95% CI 1.13 to 1.16) were observed among exposed workers compared with unexposed workers. Exposure-response relationships were observed (all outcomes) although increases in risk were non-monotonic. Trend tests suggested increased risk (<i>p trend <0.001</i>).</p><p><strong>Conclusions: </strong>This study improves understanding of DEE-related diseases. These results could be used to improve prevention efforts and workers compensation practices for DEE-related occupational diseases.</p>","PeriodicalId":19459,"journal":{"name":"Occupational and Environmental Medicine","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147777271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between parental firefighting status and adverse birth outcomes in Arizona: a cross-sectional study. 亚利桑那州父母消防状态与不良分娩结局之间的关系:一项横断面研究。
IF 3.1 2区 医学
Occupational and Environmental Medicine Pub Date : 2026-04-29 DOI: 10.1136/oemed-2025-110634
Paulina Luna Ramirez, Michelle Valenti, Caitlin Clarkson Pereira, Maia Brown, Stuart Sherman, John Gulotta, Melissa A Furlong, Jefferey L Burgess, Leslie V Farland
{"title":"Association between parental firefighting status and adverse birth outcomes in Arizona: a cross-sectional study.","authors":"Paulina Luna Ramirez, Michelle Valenti, Caitlin Clarkson Pereira, Maia Brown, Stuart Sherman, John Gulotta, Melissa A Furlong, Jefferey L Burgess, Leslie V Farland","doi":"10.1136/oemed-2025-110634","DOIUrl":"https://doi.org/10.1136/oemed-2025-110634","url":null,"abstract":"<p><strong>Background: </strong>Firefighters are continuously exposed to hazardous conditions including smoke, chemicals, stress, long work shifts and exhaustion, which may lead to a higher risk for chronic conditions and reproductive health issues. However, there is limited research looking at the association between parental firefighting with adverse birth outcomes. This cross-sectional study aimed to determine whether female or male firefighting was associated with adverse birth outcomes.</p><p><strong>Methods: </strong>Arizona birth certificates for the years 2006-2013 were used to compare firefighters with teachers, law enforcement officers and all other occupations while stratifying by sex. Logistic regression models estimated ORs and 95% CIs.</p><p><strong>Results: </strong>We included 720 686 births, 5490 paternal firefighters and 376 maternal firefighters. Maternal firefighting was associated with increased odds of preterm birth compared with teachers (OR: 1.46, 95% CI 1.06 to 1.97) and all other occupations (OR: 1.41, 95% CI 1.02 to 1.88). Higher odds for neonatal intensive care unit admission were observed when compared with teachers (OR: 1.77, 95% CI 1.22 to 2.48), law enforcement officers (OR: 1.74, 95% CI 1.07 to 2.81) and all other occupations (OR: 1.84, 95% CI 1.30 to 2.56). Paternal firefighting was statistically significantly associated with decreased caesarean section and low birth weight.</p><p><strong>Conclusions: </strong>Female firefighters may have higher odds of adverse birth outcomes. Further research should aim on understanding the biological mechanism behind these associations and ways to mitigate the risk in this population.</p>","PeriodicalId":19459,"journal":{"name":"Occupational and Environmental Medicine","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147777548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Irritant occupational exposure and specific-IgE sensitisation in the EGEA cohort. EGEA队列中的刺激性职业暴露和特异性ige致敏。
IF 3.1 2区 医学
Occupational and Environmental Medicine Pub Date : 2026-04-27 DOI: 10.1136/oemed-2025-110266
Nicolas Migueres, Orianne Dumas, Anne Boudier, Jean Bousquet, Raphäelle Varraso, Rachel Nadif, Rudolf Valenta, Frederic de Blay, Nicole Le Moual, Valérie Siroux
{"title":"Irritant occupational exposure and specific-IgE sensitisation in the EGEA cohort.","authors":"Nicolas Migueres, Orianne Dumas, Anne Boudier, Jean Bousquet, Raphäelle Varraso, Rachel Nadif, Rudolf Valenta, Frederic de Blay, Nicole Le Moual, Valérie Siroux","doi":"10.1136/oemed-2025-110266","DOIUrl":"https://doi.org/10.1136/oemed-2025-110266","url":null,"abstract":"<p><strong>Objectives: </strong>The effect of occupational irritants on IgE sensitisation remains unknown. We investigated the association between occupational exposure to irritants and IgE sensitisation.</p><p><strong>Methods: </strong>The study included a cross-sectional analysis of 924 adult participants to the first follow-up of the Epidemiological study of the Genetics and Environment of Asthma (EGEA2) and a longitudinal analysis of 271 children recruited at EGEA1 and followed up to adulthood (EGEA2). Allergen-specific IgE sensitisation to 162 allergens was assessed by microarray technology. Lifetime occupational exposure to irritants was evaluated by the occupational asthma-specific job-exposure matrix. Adjusted regression models were performed to evaluate (1) cross-sectional associations between irritant exposures with the number and cluster-based profiles of sIgE sensitisation and (2) longitudinal associations between childhood sIgE sensitisation and occupational irritant exposures in adulthood to assess a potential 'healthy hire effect'.</p><p><strong>Results: </strong>Among adult-onset asthma participants, occupational exposure to irritants was associated with a lower number of sIgE sensitisation (adjusted mean ratio=0.63 (95% CI 0.39 to 1.02), p=0.06) and a lower risk of exhibiting house dust mite predominant and pollen/animal predominant sIgE sensitisation profiles (p=0.02 and 0.06 respectively). No association was observed in participants without asthma or with childhood-onset asthma. The longitudinal assessment showed no association.</p><p><strong>Conclusion: </strong>This study, showing fewer sIgE sensitisations associated with occupational exposure to irritants in participants with adult-onset asthma but not in those with childhood-onset or no asthma, highlights the need to further explore the non-immunological mechanisms associated with exposure to respiratory irritants at work.</p>","PeriodicalId":19459,"journal":{"name":"Occupational and Environmental Medicine","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147777335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Between stings and smoke: prevalence of allergic disorders and exposure to combustion smokes in Northeast Italy's beekeepers. 在刺痛和烟雾之间:意大利东北部养蜂人的过敏性疾病和暴露于燃烧烟雾的患病率。
IF 3.1 2区 医学
Occupational and Environmental Medicine Pub Date : 2026-04-27 DOI: 10.1136/oemed-2025-110392
Marcella Mauro, Alice Tassinari, Federico Cavallo Ronchi, Marco Rizzo, Francesca Larese Filon
{"title":"Between stings and smoke: prevalence of allergic disorders and exposure to combustion smokes in Northeast Italy's beekeepers.","authors":"Marcella Mauro, Alice Tassinari, Federico Cavallo Ronchi, Marco Rizzo, Francesca Larese Filon","doi":"10.1136/oemed-2025-110392","DOIUrl":"https://doi.org/10.1136/oemed-2025-110392","url":null,"abstract":"<p><strong>Objectives: </strong>Beekeepers are frequently exposed to bee venom and combustion smoke, leading to risks of systemic allergic reactions and respiratory hazards. This study assesses the prevalence of systemic allergic symptoms among beekeepers in Northeastern Italy and describes current management practices. Additionally, it characterises inhalation exposures to combustion smoke during apiary maintenance.</p><p><strong>Methods: </strong>A cross-sectional survey collected data on sting exposure, allergic symptoms and smoke use practices. Combustion smoke exposure assessment was performed using Fourier transform infrared spectroscopy (Gasmet DX-4030) coupled with an ultrafine particle classifier (DiSCmini) to characterise emissions from commonly used fuels.</p><p><strong>Results: </strong>Among 553 beekeepers surveyed, 21.3% reported systemic allergic reactions after bee sting, mostly males (66.7%). Of these (n=118), only 31.4% were confirmed sensitised to <i>Apis mellifera</i> and prescribed epinephrine autoinjector; 16.1% received venom immunotherapy, while others had no specific allergological assessment. Multivariate analysis showed that allergic symptoms during apiary work and extended local reactions increased the likelihood of systemic reactions fivefold. Almost all participants used smoke during inspections, with 39.1% frequently inhaling smoke; only 0.9% used respiratory protective equipment. Environmental monitoring detected multiple volatile organic compounds-including formaldehyde exceeding at different time points the threshold limit value-short term exposure limits-and high concentrations of ultrafine particles, particularly from hay and pellet combustion.</p><p><strong>Conclusions: </strong>Systemic allergic reactions to bee venom are common but often undertreated in beekeepers. Combustion smoke is a significant respiratory hazard. Targeted interventions are needed to improve health outcomes and safety in this occupational group.</p>","PeriodicalId":19459,"journal":{"name":"Occupational and Environmental Medicine","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147777156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Experimentally recreated workplace environments contain submicron crystalline silica particles, including ultrafine particles, which have been identified in the mediastinal lymph nodes of construction workers. 实验重现的工作环境中含有亚微米结晶二氧化硅颗粒,包括超细颗粒,这些颗粒已在建筑工人的纵隔淋巴结中被发现。
IF 3.1 2区 医学
Occupational and Environmental Medicine Pub Date : 2026-04-21 DOI: 10.1136/oemed-2025-110330
Dominique Bazin, Christophe Bressot, Hester Colboc, Laurent Meunier, Hugues Begueret, Adrien Bachmeyer, Ty-Ty Heng-Pradere, Ionut Tranca, Fileto Rodriguez, Frederik Tielens, Ellie Tang, Carine Audouin, Emmanuel Letavernier, Michel Cambrelin, Jean-Francois Bernaudin, Patrick Brochard
{"title":"Experimentally recreated workplace environments contain submicron crystalline silica particles, including ultrafine particles, which have been identified in the mediastinal lymph nodes of construction workers.","authors":"Dominique Bazin, Christophe Bressot, Hester Colboc, Laurent Meunier, Hugues Begueret, Adrien Bachmeyer, Ty-Ty Heng-Pradere, Ionut Tranca, Fileto Rodriguez, Frederik Tielens, Ellie Tang, Carine Audouin, Emmanuel Letavernier, Michel Cambrelin, Jean-Francois Bernaudin, Patrick Brochard","doi":"10.1136/oemed-2025-110330","DOIUrl":"https://doi.org/10.1136/oemed-2025-110330","url":null,"abstract":"<p><strong>Objectives: </strong>Although ultrafine particles are suspected to contribute significantly to occupational exposure to crystalline silica, they have not yet been definitively identified in workplaces or human tissues.</p><p><strong>Methods: </strong>Particles were generated in three 60-minute tests in a glove box: cutting kerb or granite pavement, drilling solid cinder block. The particle concentrations per cm<sup>3</sup> of air in the box and their mean size were analysed online and using transmission electron microscopy and energy dispersive X-ray analysis (EDX). 17 mediastinal lymph node (MLN) samples from construction workers who underwent lung cancer surgery were examined by Fourier transform infrared spectroscopy (FTIR) and 8/17 by scanning electron microscopy (SEM) with EDX analysis.</p><p><strong>Results: </strong>The particle concentration was high when cutting kerb or granite pavement (10 000-20 000 cm<sup>-3</sup> and 50 000-160 000 cm<sup>-3</sup>, respectively), while below 1000 cm<sup>-3</sup> for drilling cinder block. The aerosol consisted mainly of submicron emissions with a nanometric fraction (ie, <100 nm), showing two main modes: 351 nm to 16 nm for kerb, 407 nm to <16 nm for granite pavement and 310 nm to 17 nm for cinder block processing. Ultrafine silica particles were only identified in kerb and granite cutting samples.Analysis using FTIR revealed an Si signal in 15/17 of the MLN samples and SEM and EDX analysis detected geometric particle deposition with Si spectra, particularly nano-sized particles, in the eight analysed samples.</p><p><strong>Conclusion: </strong>Ultrafine silica particles are produced in conditions that mimic typical construction work processes, but the quantity produced varies according to the task. Similar characteristics were observed in ultrafine silica particles in both MLN samples and experimental aerosols.</p>","PeriodicalId":19459,"journal":{"name":"Occupational and Environmental Medicine","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147777279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use of pharmacotherapy for alcohol use disorders and the risk of unemployment: a cohort study of 77 503 workers in Sweden. 酒精使用障碍药物治疗与失业风险:瑞典77503名工人的队列研究
IF 3.1 2区 医学
Occupational and Environmental Medicine Pub Date : 2026-04-17 DOI: 10.1136/oemed-2025-110613
Devy L Elling, Melody Almroth, Kristina Berglund, Anders Hammarberg, Lluís Mangot-Sala, Heidi Taipale, Jari Tiihonen, Emelie Thern
{"title":"Use of pharmacotherapy for alcohol use disorders and the risk of unemployment: a cohort study of 77 503 workers in Sweden.","authors":"Devy L Elling, Melody Almroth, Kristina Berglund, Anders Hammarberg, Lluís Mangot-Sala, Heidi Taipale, Jari Tiihonen, Emelie Thern","doi":"10.1136/oemed-2025-110613","DOIUrl":"10.1136/oemed-2025-110613","url":null,"abstract":"<p><strong>Objective: </strong>Alcohol use disorders (AUDs) can lead to unemployment, yet they remain undertreated. Pharmacotherapies may strengthen labour market attachment but are underused. This study investigates the association between AUD pharmacotherapy use and the risk of becoming unemployed among individuals with an AUD diagnosis in Sweden.</p><p><strong>Methods: </strong>A longitudinal register-based study was conducted, using the Swedish Work, Illness and labour market Participation (SWIP) cohort, restricted to gainfully employed individuals between 16 and 60 years with a first-time AUD diagnosis in Sweden between 2006 and 2019 (n=77 503). The exposure was AUD pharmacotherapy use. The outcome was the first unemployment spell (≥90 consecutive days) that occurred after the first-time AUD diagnosis (2006-2020). Covariates included sociodemographic characteristics, comorbidities and unemployment history. The association between pharmacotherapy use and unemployment was examined using Cox regression models.</p><p><strong>Results: </strong>Of the cohort, 42.8% used AUD pharmacotherapy and 15 098 individuals became unemployed during the observation period (median 7.1 years, IQR 3.3-10.6 years). Relative to those with AUD who did not use any pharmacotherapy, an inverse association between the use of AUD pharmacotherapy and unemployment incidence was observed (adjusted HR (aHR): 0.86; 95% CIs 0.82 to 0.89).</p><p><strong>Conclusions: </strong>AUD pharmacotherapy may decrease the risk of long-term unemployment. The findings further underscore the importance of pharmacotherapy treatment to sustain work ability and promote a healthy workforce.</p>","PeriodicalId":19459,"journal":{"name":"Occupational and Environmental Medicine","volume":" ","pages":"23-28"},"PeriodicalIF":3.1,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13151522/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147609427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inequalities in NHS staff support among those from ethnic minority and migrant groups during the COVID-19 pandemic. 2019冠状病毒病大流行期间,少数民族和移民群体在NHS工作人员支持方面的不平等现象。
IF 3.1 2区 医学
Occupational and Environmental Medicine Pub Date : 2026-04-17 DOI: 10.1136/oemed-2025-110203
Bethany Croak, Danielle Lamb, Sharon A M Stevelink, Rupa Bhundia, Juliana Onwumere, Brendan Dempsey, Pamela Almeida-Meza, Zoe Chui, Neil Greenberg, Rosalind Raine, Charlotte Woodhead, Stephani L Hatch, Rebecca Rhead
{"title":"Inequalities in NHS staff support among those from ethnic minority and migrant groups during the COVID-19 pandemic.","authors":"Bethany Croak, Danielle Lamb, Sharon A M Stevelink, Rupa Bhundia, Juliana Onwumere, Brendan Dempsey, Pamela Almeida-Meza, Zoe Chui, Neil Greenberg, Rosalind Raine, Charlotte Woodhead, Stephani L Hatch, Rebecca Rhead","doi":"10.1136/oemed-2025-110203","DOIUrl":"10.1136/oemed-2025-110203","url":null,"abstract":"<p><strong>Objectives: </strong>During the COVID-19 pandemic, National Health Service staff support services were implemented to promote healthcare workers' (HCWs) well-being, alongside informal support from colleagues and managers. Certain groups may be less likely to access support, including HCWs from ethnic minority and migrant groups. These HCWs are more likely to experience discrimination and abuse at work, which may also erode access to positive and protective resources. Therefore, this study examined variation in formal support programme use and perceptions of support from managers and colleagues by ethnicity and migration status.</p><p><strong>Methods: </strong>This study analysed survey data from 9769 HCWs in England who completed the baseline survey (launched April 2020) and the 6-month follow-up using descriptive statistics and binary logistic regression.</p><p><strong>Results: </strong>At 6 months, 51% of participants met the threshold for probable common mental disorder. HCWs from White Other (Adjusted Odds Ratio (AOR) 0.79; 95% CI 0.64 to 0.99) and Asian ethnic groups (AOR 0.65; 95% CI 0.57 to 0.74) were less likely to feel supported by their colleagues than White British HCWs. Similarly, those born outside of the UK and European Union were less likely to feel supported by their colleagues than UK-born HCWs (AOR 0.70; 95% CI 0.52 to 0.94). No variations in support programme use or manager support were found across ethnicity or migration status.</p><p><strong>Conclusions: </strong>The study suggests equitable formal support but identified critical disparities in perceived support from colleagues for HCWs during the COVID-19 pandemic. Improving workplace well-being should address the underlying social and structural factors that influence peer support and belonging.</p>","PeriodicalId":19459,"journal":{"name":"Occupational and Environmental Medicine","volume":" ","pages":"29-35"},"PeriodicalIF":3.1,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13151436/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147633899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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