Occupational and Environmental Medicine最新文献

{"title":"Mesothelioma risks and cumulative exposure to elongate mineral particles of various sizes in Minnesota taconite mining industry.","authors":"Yuan Shao, Gurumurthy Ramachandran, Jeffrey H Mandel, Richard F MacLehose, Bruce H Alexander","doi":"10.1136/oemed-2024-109647","DOIUrl":"10.1136/oemed-2024-109647","url":null,"abstract":"<p><strong>Objectives: </strong>An excess of mesothelioma has been previously observed in iron ore miners in Northeastern Minnesota. This study explored the potential association between mesothelioma and elongate mineral particle (EMP) exposures in the Minnesota taconite mining industry, examining both regulated and non-regulated EMP dimensions.</p><p><strong>Methods: </strong>A nested case-control study design within the Mineral Resources Health Assessment Programme cohort analysed 104 mesothelioma cases and 410 controls. Cumulative EMP exposures were assessed across various dimensional definitions, including regulated (National Institute for Occupational Safety and Health, NIOSH) and non-regulated EMPs. Conditional logistic regression models were applied to estimate mesothelioma risk linked to employment duration and cumulative EMP exposure while adjusting for potential confounding variables.</p><p><strong>Results: </strong>Consistent with earlier assessments, mesothelioma was associated with the number of years employed in the taconite industry (rate ratio (RR) 1.02, 95% CI 1.00 to 1.05) and cumulative NIOSH EMP exposure ((EMP/cc)×years) in taconite mining and processing (RR 1.20, 95% CI 0.99 to 1.46). Positive associations were also observed with mesothelioma and cumulative exposure to non-regulated EMPs.</p><p><strong>Conclusions: </strong>This study supported the main conclusions in the previous study that the data were consistent with an association between mesothelioma and employment duration and with NIOSH EMP exposure in taconite mining and processing. However, the 95% CI indicates the data are also compatible with a null effect. Given the limitations we cite in the manuscript, additional study is needed to clarify the effect. Additionally, this study found possible evidence of a positive association between mesothelioma and cumulative exposure to Chatfield EMP, Suzuki EMP and Cleavage Fragments in the Minnesota taconite worker population.</p>","PeriodicalId":19459,"journal":{"name":"Occupational and Environmental Medicine","volume":" ","pages":"7-13"},"PeriodicalIF":3.9,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Opioid use among injured workers: pain and the return-to-work experience.","authors":"Victoria Nadalin, Nancy Carnide, Cameron Mustard, Colette N Severin, Andrea D Furlan, Peter M Smith","doi":"10.1136/oemed-2024-109745","DOIUrl":"10.1136/oemed-2024-109745","url":null,"abstract":"<p><strong>Objective: </strong>In this cross-sectional analysis, we explored how return-to-work (RTW) experiences and postinjury pain are associated with opioid use after a workplace injury/illness.</p><p><strong>Methods: </strong>Workers with accepted lost-time claims, compensated by the workers' compensation board in Ontario, Canada were interviewed by telephone 18 months following a work-related physical injury/illness. Participants were asked about their past-year opioid use, current pain, RTW timing and workplace accommodations. Separate logistic regression analyses were conducted to estimate the association between two independent variables and opioid use: one combining the presence of pain with workplace accommodation and a second combining the presence of pain with RTW timing, adjusted for sociodemographic, work, injury and health covariates.</p><p><strong>Results: </strong>Of 1793 participants included in the analysis, 35.6% used opioids more than once in the past 12 months. Compared with those who did not return to work too soon and had no/mild pain, odds of opioid use were higher among those with severe pain, both those who returned too soon (OR 2.90, 95% CI 2.11 to 3.99) and those who did not return too soon (OR 3.01, 95% CI 2.16 to 4.19). Compared with those who had an offer of accommodation and no/mild pain, workers with severe pain and an accommodation offer (OR 2.78, 95% CI 2.16 to 3.57) or without an offer (OR 2.69, 95% CI 1.90 to 3.81) had increased odds of reporting use of opioids.</p><p><strong>Conclusions: </strong>Findings suggest pain is the main factor associated with opioid use after a work-related injury, irrespective of RTW experiences. However, due to the limitations of this exploratory analysis, longitudinal research examining this issue is warranted.</p>","PeriodicalId":19459,"journal":{"name":"Occupational and Environmental Medicine","volume":" ","pages":"49-52"},"PeriodicalIF":3.9,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143409435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between biosecurity and zoonotic transmission of LA-MRSA CC398 from industrial pig farms to farm workers and their household members.","authors":"Peter Bager, Md Zohorul Islam, Tinna Ravnholt Urth, Luca Guardabassi, Peter Damborg, Carmen Espinosa-Gongora, Anne Mette Madsen, Raphael Niklaus Sieber, Poul Bækbo, Robert Skov, Jesper Larsen","doi":"10.1136/oemed-2024-109620","DOIUrl":"10.1136/oemed-2024-109620","url":null,"abstract":"<p><strong>Background: </strong>Zoonotic transmission of livestock-associated methicillin-resistant <i>Staphylococcus aureus</i> clonal complex 398 (LA-MRSA CC398) from industrial pig farms to farm workers and their household members and secondary transmission to elderly and immunocompromised persons has led to a growing number of serious infections and even death.</p><p><strong>Objective: </strong>We tested the hypothesis that conventional pig farms confer a higher risk for LA-MRSA CC398 carriage among farm workers and their household members than specific pathogen-free (SPF) farms, which follow a set of stringent rules concerning biosecurity, health control and transportation of pigs between herds.</p><p><strong>Methods: </strong>We conducted a cross-sectional study of farm workers and their household members from 25 Danish pig farms positive for LA-MRSA CC398. Questionnaires were designed to obtain information about each farm and participant. Nasal samples from pigs and human volunteers were screened for LA-MRSA CC398. Multivariate logistic regression analyses were used to calculate adjusted ORs (aORs) and 95% CIs.</p><p><strong>Results: </strong>The study included 25 pig farms, 154 farm workers screened at the farm (93 of whom were also screened at home) and 173 household members. The risk of LA-MRSA CC398 carriage among farm workers at the farm (aOR=5.40, 95% CI 1.05 to 27.80) and household members (aOR=8.32; 95% CI 2.81 to 24.63) was significantly higher in conventional pig farms than in SPF farms.</p><p><strong>Conclusions: </strong>This study shows that strict biosecurity measures reduce the risk of LA-MRSA CC398 carriage among farm workers and their household members and thereby the disease burden in the general population.</p>","PeriodicalId":19459,"journal":{"name":"Occupational and Environmental Medicine","volume":" ","pages":"45-48"},"PeriodicalIF":3.9,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occupational risk factors for thumb carpometacarpal joint osteoarthritis: a register-based study of construction workers.","authors":"Charlotte Lewis, Jennie A Jackson, Albin Stjernbrandt, Gustav Andersson, Sebastian Mukka, Jens Wahlström, Per Liv","doi":"10.1136/oemed-2024-109949","DOIUrl":"10.1136/oemed-2024-109949","url":null,"abstract":"<p><strong>Objectives: </strong>The study investigated the association between occupational biomechanical risk factors and the occurrence of thumb carpometacarpal joint osteoarthritis (CMC1 OA) in construction workers.</p><p><strong>Methods: </strong>Male construction workers (n=237 525), participating in a Swedish occupational surveillance programme between 1971 and 1993, were followed between 1997 and 2019. CMC1 OA diagnoses were identified through linkage with national medical registries. Job title, smoking status, height, weight and age were collected from the surveillance programme. A job exposure matrix (JEM) was developed with exposure estimates on biomechanical risk factors for each occupational group. Relative risk (RR) of CMC1 OA diagnosis was calculated using a Poisson regression model.</p><p><strong>Results: </strong>There was an increased risk of CMC1 OA for all biomechanical risk factors (RR range 1.3-1.5). Exposure-response patterns were seen for repetitive wrist flexion and extension (low: RR 1.30 (95% CI 1.07 to 1.59), moderate: 1.32 (95% CI 1.07 to 1.62), high: 1.45 (95% CI 1.19 to 1.75)), wrist extension (low: 1.31 (95% CI 1.09 to 1.59), moderate: 1.41 (95% CI 1.17 to 1.70) and heavy lifting (low: 1.13 (95% CI 0.92 to 1.38), moderate: 1.45 (95% CI 1.18 to 1.77), high: 1.50 (95% CI 1.24 to 1.82). Electricians (1.29 (95% CI 1.03 to 1.89)), concrete workers (1.31 (95% CI 1.02 to 1.67)), plumbers (1.37 (95% CI 1.07 to 1.76)), sheet-metal workers (1.58 (95% CI 1.18 to 2.10)), wood workers (1.66 (95% CI 1.36 to 2.03)), repairers (1.75 (95% CI 1.06 to 2.90)) and glass workers (2.21 (95% CI 1.42 to 3.44) had an increased risk of CMC1 OA compared with the reference group.</p><p><strong>Conclusion: </strong>Wrist movements and hand loading were associated with CMC1 OA.</p>","PeriodicalId":19459,"journal":{"name":"Occupational and Environmental Medicine","volume":" ","pages":"14-20"},"PeriodicalIF":3.9,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exposure to ambient high temperature and increased risk of hospitalisation for non-infectious bowel diseases during 2000-2019: a case-crossover study in 1816 Brazilian cities.","authors":"Mengwei Zhuang, Yanwen Cao, Micheline de Sousa Zanotti Stagliorio Coelho, Yuming Guo, Shanshan Li, Tao Huang, Jie Yan, Qi Zhao","doi":"10.1136/oemed-2024-109710","DOIUrl":"10.1136/oemed-2024-109710","url":null,"abstract":"<p><strong>Objectives: </strong>Although human intestine is sensitive to high ambient temperature, the heat-related morbidity burden remains rarely explored. This study quantified the association between high ambient temperature and non-infectious bowel disease (NBD) hospitalisations in Brazil during 2000-2019-a country experiencing substantial threats both from global warming and NBDs.</p><p><strong>Methods: </strong>Daily data on weather and NBD hospitalisations were collected from 1816 cities. A time-stratified case-crossover design was used to assess the effect size of ambient temperature during the hot season. Stratified analysis by regions, population subgroups and disease types was performed.</p><p><strong>Results: </strong>For each 5℃ increase in mean daily temperature, the cumulative OR of NBD hospitalisation over lag 0-3 days was 1.042 (95% CI 1.031 to 1.054) at the national level, reaching the maximum in the northeast and the minimum in the southeast. Assuming a causal relationship, ambient heat exposure explained 12.09% (95% CI 8.69% to 15.09%) of the total hospitalisations. The effect size was the highest in the youth, with no significant gender difference observed. Inflammation-related and function-related NBDs showed significantly higher susceptibility compared with other types of NBDs. The cumulative effect of ambient high temperature attenuated over the 20 years and from early to late hot season, suggesting both long-term and intraseasonal adaptations to heat.</p><p><strong>Conclusions: </strong>The spatial, temporal and demographic variations in the strength of association should be considered for the development of health preventive strategies towards extreme ambient heat.</p>","PeriodicalId":19459,"journal":{"name":"Occupational and Environmental Medicine","volume":" ","pages":"28-35"},"PeriodicalIF":3.9,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship of long-term air pollution exposure with chronic obstructive pulmonary disease: an Italian multicentre observational study.","authors":"Sara Maio, Salvatore Fasola, Alessandro Marcon, Anna Angino, Sandra Baldacci, Maria Beatrice Bilò, Roberto Bono, Alessandro Giuseppe Fois, Stefania La Grutta, Pierpaolo Marchetti, Giuseppe Sarno, Giulia Squillacioti, Ilaria Stanisci, Pietro Pirina, Sofia Tagliaferro, Giuseppe Verlato, Simona Villani, Claudio Gariazzo, Massimo Stafoggia, Giovanni Viegi","doi":"10.1136/oemed-2024-109650","DOIUrl":"10.1136/oemed-2024-109650","url":null,"abstract":"<p><strong>Background: </strong>Recent evidence showed that 50% of chronic obstructive pulmonary disease (COPD) may be attributable to air pollution. We aimed to investigate the association between long-term air pollution exposure and COPD symptoms/diagnosis in an Italian epidemiological study.</p><p><strong>Methods: </strong>A total of 14 420 adults living in Ancona, Pavia, Pisa, Sassari, Turin and Verona were investigated in 2005-2011. Data on risk factors and health outcomes were collected by questionnaires; mean annual concentrations of particulate matters (PM) like PM₁₀ and PM_2.5 as well as NO₂ and mean summer concentrations of O₃ (µg/m³) at residential level with a 1 km resolution (period 2013-2015) were obtained by machine learning techniques. The relationship of pollutant exposure and COPD prevalence was assessed by logistic regression models (single pollutant) and principal component logistic regression models (multipollutant) adjusting for sex, age, education level, smoking habits, season of interview, and city-specific climatic index and including a random intercept for cohorts.</p><p><strong>Results: </strong>A 10 µg/m³ increase of PM₁₀, PM_2.5 and NO₂ exposure was related to COPD diagnosis and symptoms (OR 1.31, 95% CI 1.03 to 1.65 for PM_2.5; OR 1.26, 95% CI 1.03 to 1.54 for PM₁₀ and OR 1.07, 95% CI 1.00 to 1.15 for NO₂) using a multipollutant approach. Similar results emerged for dyspnoea (OR 1.24, 95% CI 1.05 to 1.47 for PM_2.5; OR 1.21, 95% CI 1.05 to 1.39 for PM₁₀ and OR 1.06, 95% CI 1.01 to 1.11 for NO₂). Associations between COPD symptoms and summer O₃ were less clear. By multipollutant models, OR estimates were lower than those by single pollutant models.</p><p><strong>Conclusions: </strong>Further evidence about the relationship between air pollution and respiratory effects in Italian adults was provided indicating PM as the main driver.</p>","PeriodicalId":19459,"journal":{"name":"Occupational and Environmental Medicine","volume":" ","pages":"21-27"},"PeriodicalIF":3.9,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Melatonin supplementation and oxidative DNA damage repair capacity among night shift workers: a randomised placebo-controlled trial.","authors":"Umaimah Zanif, Agnes S Lai, Jaclyn Parks, Aina Roenningen, Christopher B McLeod, Najib Ayas, Xiangtian Wang, Yan Lin, Junfeng Jim Zhang, Parveen Bhatti","doi":"10.1136/oemed-2024-109824","DOIUrl":"10.1136/oemed-2024-109824","url":null,"abstract":"<p><strong>Objectives: </strong>A decreased ability to repair oxidative DNA damage, due to melatonin suppression, is a compelling mechanism by which night shift workers are at an increased risk of cancer. We sought to determine if melatonin supplementation would improve oxidative DNA damage repair among night shift workers.</p><p><strong>Methods: </strong>We conducted a parallel-arm randomised placebo-controlled trial of melatonin supplementation among 40 night shift workers. Supplements were consumed before engaging in day sleep over a 4-week period. All urine excreted during a representative day sleep and night work period before and during the intervention period was collected for measurement of creatinine-adjusted 8-hydroxy-2'-deoxyguanosine (8-OH-dG) as an indicator of oxidative DNA damage repair capacity, with higher concentrations indicating better repair. Linear regression models were used to analyse the association between ln-transformed 8-OH-dG concentration and intervention status during day sleep and night work.</p><p><strong>Results: </strong>The melatonin intervention was associated with a borderline statistically significant 1.8-fold increase in urinary 8-OH-dG excretion during day sleep (95% CI 1.0, 3.2, p=0.06). No statistically significant difference in 8-OH-dG excretion was observed during the subsequent night shift (melatonin vs placebo excretion ratio=0.9; 95% CI 0.6, 1.5; p=0.7).</p><p><strong>Conclusions: </strong>Our results suggest that melatonin supplementation improves oxidative DNA damage repair capacity among night shift workers. Future larger-scale trials are needed to evaluate the impact of varying doses of melatonin supplements and examine the impacts of longer-term use of melatonin supplements by night shift workers.</p>","PeriodicalId":19459,"journal":{"name":"Occupational and Environmental Medicine","volume":" ","pages":"1-6"},"PeriodicalIF":3.9,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occupational exposure to respirable and inhalable dust and its components in a Nicaraguan sugarcane plantation.","authors":"Antonio d'Errico, Sandra Peraza, Ilana Weiss, William Martinez, Esteban Arias Monge, Inge Maria Wouters, David H Wegman, Kristina Jakobsson, Hans Kromhout","doi":"10.1136/oemed-2024-109604","DOIUrl":"10.1136/oemed-2024-109604","url":null,"abstract":"<p><strong>Objective: </strong>To assess personal exposure to respirable and inhalable dust and its components endotoxin, black carbon and crystalline silica among sugarcane workers in Nicaragua.</p><p><strong>Methods: </strong>Individual exposures to respirable (measurements=98) and inhalable (measurements=36) dust were collected in January and March 2020, with the month of March generally being hotter and less humid. Respirable dust and its components black carbon and crystalline silica, as well as inhalable dust and its component endotoxin, were personally measured. Linear mixed models were used to identify the determinants of occupational dust exposure considering different job tasks and meteorological conditions.</p><p><strong>Results: </strong>Respirable dust and black carbon concentrations were higher in March among burned cane cutters compared with the other job groups (respirable dust geometric mean (GM)=1.9 mg m^-3; black carbon GM=13.7 µg m^-3), with considerably lower levels in January (respirable dust GM=0.2 mg m^-3; black carbon GM=3.4 µg m^-3). Almost all respirable crystalline silica measurements were below the limit of detection, except for four measurements, which ranged from 8 µg m^-³ to 15 µg m^-³. Seed cutters (GM=3.1 mg m^-3) and weeders (GM=2.5 mg m^-3) had the highest exposure to inhalable dust, while endotoxin concentrations were higher among seed cutters (GM=100 EU m^-3) and burned cane cutters (GM=63 EU m^-3) than the other work groups.</p><p><strong>Conclusions: </strong>Overall, exposure levels to the assessed agents varied across work groups, with higher levels observed among burned cane and seed cutters.</p>","PeriodicalId":19459,"journal":{"name":"Occupational and Environmental Medicine","volume":" ","pages":"36-43"},"PeriodicalIF":3.9,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of sedentary behaviour reduction on desk-worker workplace satisfaction, productivity, mood and health-related quality of life: a randomised trial.","authors":"Tyler D Quinn, Subashan Perera, Molly B Conroy, John M Jakicic, Matthew F Muldoon, Kimberly A Huber, Abdullah B Alansare, Anthony J Holmes, Bethany Barone Gibbs","doi":"10.1136/oemed-2024-109868","DOIUrl":"https://doi.org/10.1136/oemed-2024-109868","url":null,"abstract":"<p><strong>Objectives: </strong>Sedentary behaviour (SB) is related to lower worker health-related quality of life (HRQOL), mental health and productivity. However, it is unknown whether reducing SB improves these outcomes. This study assessed whether a 3-month SB reduction intervention improved or was associated with dose-response changes in workplace satisfaction, productivity, mood and HRQOL.</p><p><strong>Methods: </strong>Inactive desk workers with elevated blood pressure were randomised to a 3-month SB reduction intervention (n=135) or control (n=136). The intervention used a sit-stand desk, wrist-worn activity prompter and bi-monthly individual coaching to primarily replace work SB with standing and stepping. SB measured via a thigh-mounted activPAL3 micro, workplace satisfaction, productivity, mood and HRQOL were assessed at baseline and 3 months. Analyses of covariance compared changes in outcomes between groups with adjustment for baseline values. In both groups, associations between changes in work and non-work SB and outcomes were examined using linear regression.</p><p><strong>Results: </strong>Compared with control, reducing SB did not significantly change workplace satisfaction, productivity or HRQOL. Among mood measures, only vigour improved (1.01 vs 0.1 points, p=0.0302). Among all participants, reductions in non-work SB were associated with improvements in workplace satisfaction (+0.15 and +0.27 points/hour of non-work standing and stepping, respectively) and productivity (+0.47 points/hour of non-work stepping), while changes in SB during work were not related.</p><p><strong>Conclusions: </strong>Interventions reducing non-work rather than work SB may be more impactful for improving workplace satisfaction and HRQOL outcomes. Future studies should explore workplace-based SB reduction interventions that are longer and target non-work time to improve similar outcomes.</p><p><strong>Trial registration number: </strong>NCT03307343.</p>","PeriodicalId":19459,"journal":{"name":"Occupational and Environmental Medicine","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular mortality among seafarers: a Danish nationwide cohort study.","authors":"Anna Uhd Bøge, Sören Möller, Rune Lindahl-Jacobsen, Lisa Loloma Froholdt, Kimmo Herttua, Linda Juel Ahrenfeldt","doi":"10.1136/oemed-2024-109885","DOIUrl":"https://doi.org/10.1136/oemed-2024-109885","url":null,"abstract":"<p><strong>Objectives: </strong>Cardiovascular disease (CVD) is the leading cause of death globally and the second most frequent cause of death in Denmark. Due to their unique occupational environment, seafarers are exposed to numerous risk factors for CVD including lifestyle and work-related factors. This study aims to investigate CVD mortality among Danish seafarers by comparing them to the economically active reference population.</p><p><strong>Methods: </strong>This register-based cohort study included data on all Danish seafarers from 1993 to 2016 and compared them with the economically active Danish population not working as seafarers. The seafarers' mortality was calculated using piecewise stratified Cox regression adjusting for potential confounders. Mortality was further analysed by diagnosis groups, vessel type and employment duration.</p><p><strong>Results: </strong>Among 52 861 seafarers, 4226 deaths were observed, with 866 (20.5%) of these attributed to CVD. Male seafarers had higher all-cause mortality in age groups 18-44 years (HR 1.46, 95% CI 1.33 to 1.62), 45-64 years (HR 1.43, 95% CI 1.37 to 1.50) and 65+ years (HR 1.32, 95% CI 1.26 to 1.39) compared with the reference population. CVD mortality was increased for male seafarers aged 45-64 years (HR 1.27, 95% CI 1.13 to 1.42) and 65+ years (HR 1.34, 95% CI 1.21 to 1.48). The mortality was higher for male seafarers for ischaemic heart diseases, other forms of heart diseases, cerebrovascular diseases and diseases of arteries, arterioles and capillaries. CVD mortality was also observed based on vessel type.</p><p><strong>Conclusions: </strong>The study provides evidence of elevated CVD mortality among Danish seafarers. Future research should focus on identifying effective strategies to improve the cardiovascular health of seafarers.</p>","PeriodicalId":19459,"journal":{"name":"Occupational and Environmental Medicine","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}