Occupational and Environmental Medicine最新文献

OPERAS decision support system versus manual job coding: a quantitative analysis on coding time and inter-coder reliability. opera决策支持系统与手工作业编码：编码时间和编码间可靠性的定量分析。

IF 3.9 2区医学

Occupational and Environmental Medicine Pub Date : 2025-06-13 DOI: 10.1136/oemed-2024-109823

Mathijs A Langezaal, Egon L van den Broek, Grégoire Rey, Nicole Le Moual, Corinne Pilorget, Marcel Goldberg, Roel Vermeulen, Susan Peters

{"title":"OPERAS decision support system versus manual job coding: a quantitative analysis on coding time and inter-coder reliability.","authors":"Mathijs A Langezaal, Egon L van den Broek, Grégoire Rey, Nicole Le Moual, Corinne Pilorget, Marcel Goldberg, Roel Vermeulen, Susan Peters","doi":"10.1136/oemed-2024-109823","DOIUrl":"https://doi.org/10.1136/oemed-2024-109823","url":null,"abstract":"Objectives: The manual coding of job descriptions is time-consuming, expensive and requires expert knowledge. Decision support systems (DSS) provide a valuable alternative by offering automated suggestions that support decision-making, improving efficiency while allowing manual corrections to ensure reliability. However, this claim has not been proven with expert coders. This study aims to fill this omission by comparing manual with decision-supported coding, using the new DSS OPERAS.Methods: Five expert coders proficient in using the French classification systems for occupations PCS2003 and activity sectors NAF2008 each successively coded two subsets of job descriptions from the CONSTANCES cohort manually and using OPERAS. Subsequently, we assessed coding time and inter-coder reliability of assigning occupation and activity sector codes while accounting for individual differences and the perceived usability of OPERAS, measured using the System Usability Scale (SUS; range 0-100).Results: OPERAS usage substantially outperformed manual coding for all coders on both coding time and inter-coder reliability. The median job description coding time was 38 s using OPERAS versus 60.8 s while manually coding. Inter-coder reliability (in Cohen's kappa) ranged 0.61-0.70 and 0.56-0.61 for the PCS, while ranging 0.38-0.61 and 0.34-0.61 for the NAF for OPERAS and manual coding, respectively. The average SUS score was 75.5, indicating good usability.Conclusions: Compared with manual coding, using OPERAS as DSS for occupational coding improved coding time and inter-coder reliability. Subsequent comparison studies could use OPERAS' ISCO-88 and ISCO-68 classification models. Consequently, OPERAS facilitates large, harmonised job coding in large-scale occupational health research.","PeriodicalId":19459,"journal":{"name":"Occupational and Environmental Medicine","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144294194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Are we underestimating indoor radon exposure in radon priority areas? 我们是否低估了氡重点地区的室内氡暴露？

IF 3.9 2区医学

Occupational and Environmental Medicine Pub Date : 2025-06-09 DOI: 10.1136/oemed-2025-110093

Lucia Martin-Gisbert, Karl T Kelsey, Alberto Ruano-Ravina

引用次数: 0

Assessing the work relatedness of diagnoses in occupational health primary care appointments: a 3-year review of electronic medical records. 评估职业卫生初级保健预约诊断的工作相关性：对电子医疗记录的3年回顾

IF 3.9 2区医学

Occupational and Environmental Medicine Pub Date : 2025-05-19 DOI: 10.1136/oemed-2024-109991

Satu Soini, Katja Riina Ryynänen, Sari Nissinen, Jouko Miettunen, Leena Ala-Mursula

{"title":"Assessing the work relatedness of diagnoses in occupational health primary care appointments: a 3-year review of electronic medical records.","authors":"Satu Soini, Katja Riina Ryynänen, Sari Nissinen, Jouko Miettunen, Leena Ala-Mursula","doi":"10.1136/oemed-2024-109991","DOIUrl":"https://doi.org/10.1136/oemed-2024-109991","url":null,"abstract":"Objectives: This is the first study to use real-life electronic medical record data from occupational health (OH) primary care to evaluate how often physicians assess and confirm diagnoses' work relatedness (the definition implying causal or aggravating factors at work) in relation to the physicians' expertise, allocated appointment time and type of diagnosis.Methods: We analysed registered data on face-to-face appointments with an occupational physician (n=70 163) at a Finnish OH service provider in 2020-2022, using cross tabulations and logistic regression to estimate the likelihood of assessments and conclusions that the diagnoses are work related, depending on whether the physician was specialised in OH, the appointment duration and the diagnoses' International Classification of Diseases-10 (ICD-10) categories.Results: The work relatedness of diagnoses was assessed in 58.1% of appointments, most likely when appointments were longer and diagnoses belonged to the ICD-10 categories of injuries, mental disorders and rarely used 'other reasons for visiting healthcare' category. The main diagnosis was considered work related in 8.9% of the appointments, more likely when the physician was an OH specialist and the appointments were longer. In the adjusted models, the highest ORs (OR, 95% CI) for the diagnoses being classed as work related were in cases of mental disorders (5.82, 5.01 to 6.76), musculoskeletal diseases (7.46, 6.66 to 8.35) and injuries (18.14, 16.06 to 20.48).Conclusion: Although a requirement, work relatedness was assessed in less than 60% of the appointments in OH primary care. Work-related diseases were rarely confirmed. Further research is required to find factors that could improve such assessments.","PeriodicalId":19459,"journal":{"name":"Occupational and Environmental Medicine","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Employer compliance with OSHA requirements for immediate reporting of severe injuries. 雇主遵守OSHA的要求，立即报告严重伤害。

IF 3.9 2区医学

Occupational and Environmental Medicine Pub Date : 2025-05-18 DOI: 10.1136/oemed-2025-110074

Lee S Friedman, Linda Forst, Brett Shannon, Chibuzor Abasilim, Dana Madigan

{"title":"Employer compliance with OSHA requirements for immediate reporting of severe injuries.","authors":"Lee S Friedman, Linda Forst, Brett Shannon, Chibuzor Abasilim, Dana Madigan","doi":"10.1136/oemed-2025-110074","DOIUrl":"10.1136/oemed-2025-110074","url":null,"abstract":"Objectives: In 2014, US Occupational Safety and Health Administration (OSHA) updated a rule requiring employers to directly report all hospitalisations, amputations and eye enucleations to OSHA within 24 hours and within 8 hours for fatalities and multiple injury events. Past studies have shown that employers under-report injuries and illnesses for numerous reasons.Methods: This study evaluated the completeness of required immediate reporting of severe injuries and illnesses by employers to OSHA by linking cases reported to OSHA with hospital data from 1 January 2017 to 31 December 2023. We evaluated factors associated with failure to report severe injuries or illnesses to OSHA using multivariable logistic regression.Results: We identified 7578 non-fatal occupational injuries and illnesses and an additional 160 fatalities treated in Illinois hospitals that were not reported to OSHA. The cumulative reporting rate for non-fatal injuries was 39.7%, while non-fatal illnesses (excluding COVID-19 cases) was 25.1%. There was no significant change in reporting rates over the 7-year period for non-fatal injuries and illnesses. Failure to report serious injuries and illnesses was associated with hospitalisations involving acute illnesses (adjusted OR (aOR)=2.60), female workers (aOR=1.29) and incidents occurring on weekends (aOR=2.21) and holidays (aOR=1.98). We also identified factors associated with improperly reporting cases that did not meet the OSHA reporting criteria.Conclusions: We estimate that failure to report these hospitalisations obscured up to 2122 violations in Illinois workplaces that could have led to remediation to protect other workers from injury. This analysis informs compliance assistance programmes that address reporting practices and record-keeping policy.","PeriodicalId":19459,"journal":{"name":"Occupational and Environmental Medicine","volume":" ","pages":"148-156"},"PeriodicalIF":3.9,"publicationDate":"2025-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12088877/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does radon cause diseases other than lung cancer? Findings on mortality within the German uranium miners cohort study, 1946-2018. 氡会引起肺癌以外的疾病吗？1946-2018年德国铀矿工人队列研究中的死亡率发现。

IF 3.9 2区医学

Occupational and Environmental Medicine Pub Date : 2025-05-18 DOI: 10.1136/oemed-2024-109923

Nora Fenske, Veronika Deffner, Maria Schnelzer, Michaela Kreuzer

{"title":"Does radon cause diseases other than lung cancer? Findings on mortality within the German uranium miners cohort study, 1946-2018.","authors":"Nora Fenske, Veronika Deffner, Maria Schnelzer, Michaela Kreuzer","doi":"10.1136/oemed-2024-109923","DOIUrl":"10.1136/oemed-2024-109923","url":null,"abstract":"Objectives: This analysis aimed at investigating the relationship between death from diseases other than lung cancer and radon exposure in the German uranium miners cohort study with follow-up data from 1946 to 2018.Methods: The cohort includes 58 975 men who were employed between 1946 and 1990 at the former 'Wismut' uranium mining company in Eastern Germany. Occupational exposure to radon progeny in working level month (WLM) was retrospectively assessed using a comprehensive job-exposure matrix. Based on internal Poisson regression, excess relative rates (ERRs) per 100 WLM were estimated for cumulative lagged exposure to radon for numerous outcomes. Sensitivity analyses examined possible confounding by occupational exposure to silica dust and gamma radiation.Results: Small but statistically significantly increased excess rates were found for the group of all cancers other than lung cancer (n=6126; ERR/100 WLM=0.014 (95% CI 0.007; 0.022)) and for ischaemic heart diseases (n=6182; 0.010 (95% CI 0.003; 0.016)). The increase in risk was particularly observed at very high exposure levels. No clear association between radon exposure and other causes of death, comprising other subgroups of circulatory system diseases, non-malignant respiratory diseases excluding pneumoconiosis, neurodegenerative diseases and the many considered individual cancer sites was present. Notable were the estimates for myeloid leukaemia (n=114; 0.076 (95% CI -0.011; 0.164)) and pharynx cancer (n=112; 0.070 (95% CI -0.041; 0.182)).Conclusions: The findings of the Wismut cohort indicate small increased risks for a few selected outcomes. Overall, the study does not provide convincing evidence for an increased risk for other diseases than lung cancer due to radon.","PeriodicalId":19459,"journal":{"name":"Occupational and Environmental Medicine","volume":" ","pages":"112-119"},"PeriodicalIF":3.9,"publicationDate":"2025-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Occupational differences in COVID-19 hospital admission and mortality risks between women and men in Scotland: a population-based study using linked administrative data. 苏格兰女性和男性在COVID-19住院和死亡风险方面的职业差异：使用相关行政数据的基于人群的研究

IF 3.9 2区医学

Occupational and Environmental Medicine Pub Date : 2025-05-18 DOI: 10.1136/oemed-2024-109562

Serena Pattaro, Nick Bailey, Chris Dibben

{"title":"Occupational differences in COVID-19 hospital admission and mortality risks between women and men in Scotland: a population-based study using linked administrative data.","authors":"Serena Pattaro, Nick Bailey, Chris Dibben","doi":"10.1136/oemed-2024-109562","DOIUrl":"10.1136/oemed-2024-109562","url":null,"abstract":"Objectives: Occupations vary with respect to workplace factors that influence exposure to COVID-19, such as ventilation, social contacts and protective equipment. Variations between women and men may arise because they have different occupational roles or behavioural responses. We estimated occupational differences in COVID-19 hospital admission and mortality risks by sex.Methods: We combined (1) individual-level data from 2011 Census with (2) health records and (3) household-level information from residential identifiers, using a Scottish cohort of 1.7 million adults aged 40-64 years between 1 March 2020 and 31 January 2021. We estimated age-standardised COVID-19 hospital admission and mortality rates, stratified by sex and occupation. Cox proportional hazards models were adjusted for pre-pandemic health and occupational exposure factors, including interaction effects between occupation and sex.Results: Women had lower age-standardised COVID-19 hospital admission and mortality rates than men. Among women, adjusted death risks were lowest for health professionals, and those in associate professional and technical occupations (paramedics and medical technicians), with the latter supported by results from the interaction model. Among men, elevated adjusted admission and death risks were observed for large vehicle and taxi drivers. Additionally, admission risks remained high among men in caring personal services (including home and care workers), while elevated risks were observed among women in customer service occupations (call centre operators) and process, plant and machine operative roles (assemblers and sorters).Conclusions: Occupational differences in COVID-19 hospital admission and mortality risks between women and men highlight the need to account for sex differences when developing interventions to reduce infections among vulnerable occupational groups.","PeriodicalId":19459,"journal":{"name":"Occupational and Environmental Medicine","volume":" ","pages":"128-137"},"PeriodicalIF":3.9,"publicationDate":"2025-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144013754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Overwork and changes in brain structure: a pilot study. 过度工作和大脑结构的变化：一项初步研究。

IF 3.9 2区医学

Occupational and Environmental Medicine Pub Date : 2025-05-18 DOI: 10.1136/oemed-2025-110057

Wonpil Jang, Sungmin Kim, YouJin Kim, Seunghyun Lee, Joon Yul Choi, Wanhyung Lee

{"title":"Overwork and changes in brain structure: a pilot study.","authors":"Wonpil Jang, Sungmin Kim, YouJin Kim, Seunghyun Lee, Joon Yul Choi, Wanhyung Lee","doi":"10.1136/oemed-2025-110057","DOIUrl":"10.1136/oemed-2025-110057","url":null,"abstract":"Objectives: To investigate the effects of overwork on brain structure to better understand its impact on workers' cognitive and emotional health. The goal was to provide evidence for the potential neurological risks associated with prolonged working hours.Methods: A total of 110 healthcare workers were classified into overworked (≥52 hours/week; n=32) and non-overworked groups (n=78). Brain volume differences were assessed using voxel-based morphometry (VBM) and atlas-based analysis. General linear models adjusted for age, sex and total intracranial volume were applied, and correlation analyses explored relationships between weekly working hours and brain volume in regions with significant differences.Results: Overworked individuals exhibited significant changes in brain regions associated with executive function and emotional regulation. Atlas-based analysis revealed a 19% increase in left caudal middle frontal gyrus volume in the overworked group compared with the non-overworked group (p=0.006). VBM showed peak increases in 17 regions, including the middle frontal gyrus, insula and superior temporal gyrus (p<0.05). Correlation analyses indicated a positive association between weekly working hours and brain volume changes in the middle frontal gyrus and insula.Conclusions: This study provides preliminary evidence that overwork is associated with structural brain changes, particularly in regions linked to cognition and emotion. These findings provide novel neurobiological evidence linking prolonged working hours to structural brain changes, emphasising the need for further research to understand the long-term cognitive and emotional implications of overwork.","PeriodicalId":19459,"journal":{"name":"Occupational and Environmental Medicine","volume":" ","pages":"105-111"},"PeriodicalIF":3.9,"publicationDate":"2025-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mortality and cancer incidence among Queensland coal mine workers: a retrospective cohort. 昆士兰煤矿工人的死亡率和癌症发病率：一个回顾性队列。

IF 3.9 2区医学

Occupational and Environmental Medicine Pub Date : 2025-05-18 DOI: 10.1136/oemed-2024-109549

Deborah Catherine Glass, Stella May Gwini, Anthony Del Monaco, Lin Fritschi, Michael John Abramson, Malcolm Ross Sim, Karen Walker-Bone

{"title":"Mortality and cancer incidence among Queensland coal mine workers: a retrospective cohort.","authors":"Deborah Catherine Glass, Stella May Gwini, Anthony Del Monaco, Lin Fritschi, Michael John Abramson, Malcolm Ross Sim, Karen Walker-Bone","doi":"10.1136/oemed-2024-109549","DOIUrl":"10.1136/oemed-2024-109549","url":null,"abstract":"Objectives: To quantify mortality and cancer incidence among Queensland coal mine workers.Methods: A cohort of coal mine workers from Queensland was linked to Australian national death and cancer registries for the period 1983-2020. Standardised mortality (SMR) and cancer incidence (SIR) ratios were calculated for men and women compared with Australian rates. Accidental deaths, suicides and melanoma incidence were also compared with Queensland rates.Results: There were 4957 deaths among 164 622 men and 211 among 24 389 women. Overall mortality was lower than the national population for men (SMR 81 (95% CI 78 to 83)) and women (SMR 75 (95% CI 65 to 86)) and for all mine types. Mortality was significantly decreased for most death categories. Male suicide mortality was significantly increased compared with the national population, but not when compared with Queensland population rates.There were 5492 men and 406 women with cancer. Overall cancer incidence was higher than the national population for men (SIR 107 (95% CI 104 to 109)) but not for women (SIR 99 (95% CI 90 to 108)). There were increased risks for melanoma, lip, lung, bladder and gallbladder cancers compared with the general Australian population for men and women, but the numbers of women were small. When compared with Queensland rates, the overall risk of melanoma was not increased.Conclusions: Consistent with the healthy worker effect, overall mortality was lower in this cohort. Cancer incidence was increased for men, but not women. The increased cancer risks highlight the need for further investigation.","PeriodicalId":19459,"journal":{"name":"Occupational and Environmental Medicine","volume":" ","pages":"120-127"},"PeriodicalIF":3.9,"publicationDate":"2025-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A less detailed job axis in a quantitative job-exposure matrix results in a similar exposure-response association. 定量工作暴露矩阵中较不详细的工作轴导致类似的暴露-反应关联。

IF 3.9 2区医学

Occupational and Environmental Medicine Pub Date : 2025-05-18 DOI: 10.1136/oemed-2024-109702

Johan Ohlander, Susan Peters, Hans Kromhout

{"title":"A less detailed job axis in a quantitative job-exposure matrix results in a similar exposure-response association.","authors":"Johan Ohlander, Susan Peters, Hans Kromhout","doi":"10.1136/oemed-2024-109702","DOIUrl":"10.1136/oemed-2024-109702","url":null,"abstract":"Introduction: Quantitative job-exposure matrices (JEMs) have been developed to assign exposure using International Standard Classification of Occupations (ISCO)-68 coded job information. For extended compatibility with the less detailed ISCO-88 coding, a quantitative JEM using the same underlying model was developed. We compared exposure-response relationships between cumulative respirable crystalline silica (RCS) and lung cancer risk using a quantitative JEM based on ISCO-88 (88-JEM) and ISCO-68 (68-JEM).Methods: Based on a common set of approximately 15 000 RCS measurements, job-specific, region-specific and time-specific exposure levels were estimated for the 88-JEM and the 68-JEM and linked to participants' job histories. Exposure-response relationships in an international lung cancer case-control study were analysed by logistic regression and generalised additive models.Results: The 88-JEM and the 68-JEM yielded similar RCS-lung cancer associations, with elevated lung cancer risks across each cumulative exposure quartile. The 88-JEM exhibited a minor not statistically significant upward bend in the exposure-response curve at higher exposures.Conclusion: To accurately detect associations between disease risk and occupational exposure, quantitative JEMs can be applied in community-based studies that provide job histories in either ISCO-88 or ISCO-68.","PeriodicalId":19459,"journal":{"name":"Occupational and Environmental Medicine","volume":" ","pages":"157-160"},"PeriodicalIF":3.9,"publicationDate":"2025-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploratory research on occupational exposures and breast cancer risk in the CECILE study. CECILE研究中职业暴露与乳腺癌风险的探索性研究。

IF 3.9 2区医学

Occupational and Environmental Medicine Pub Date : 2025-05-18 DOI: 10.1136/oemed-2024-110021

Lisa Leung, Anita Koushik, Emilie Cordina-Duverger, Jack Siemiatycki, Pascal Guénel

{"title":"Exploratory research on occupational exposures and breast cancer risk in the CECILE study.","authors":"Lisa Leung, Anita Koushik, Emilie Cordina-Duverger, Jack Siemiatycki, Pascal Guénel","doi":"10.1136/oemed-2024-110021","DOIUrl":"10.1136/oemed-2024-110021","url":null,"abstract":"Objectives: In 'exploratory mode', to examine associations between occupational exposure to 49 prevalent agents and breast cancer risk.Methods: In a French population-based case-control study on breast cancer (2005-2007), lifetime occupational histories of 1230 incident cases and 1315 controls were collected. An industrial hygienist coded each job held by a participant. Job codes were subsequently linked to the Canadian job-exposure matrix, and exposure level estimates for numerous agents were generated. Multivariable unconditional logistic regression was used to estimate associations between occupational exposure to 49 prevalent agents and breast cancer risk, adjusting for established breast cancer risk factors and selected sociodemographic covariates.Results: Increased ORs, ranging between 1.33 and 2.39, were observed for women in the highest tertile of cumulative exposure versus unexposed for the following 12 agents: sodium carbonate, synthetic fibres, wool fibres, silk fibres, organic dyes and pigments, plastic dusts, plastics pyrolysis fumes, ozone, nitrogen oxides, anaesthetic gases, aliphatic ketones and mononuclear aromatic hydrocarbons. When stratified by menopausal status, the ORs for many of these agents were stronger among premenopausal versus postmenopausal women.Conclusions: These findings suggest the possible role of some occupational agents in the aetiology of breast cancer. Further studies, based on large sample sizes and high-quality exposure assessment, are needed to confirm our findings.","PeriodicalId":19459,"journal":{"name":"Occupational and Environmental Medicine","volume":" ","pages":"139-147"},"PeriodicalIF":3.9,"publicationDate":"2025-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0