{"title":"Single Institution Experience with Immune Checkpoint Inhibitors in Vulvar and Vaginal Melanomas.","authors":"Amrita Ladwa, Omar Elghawy, Varinder Kaur","doi":"10.1155/2024/7327692","DOIUrl":"10.1155/2024/7327692","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to report clinical outcomes of patients with vaginal melanoma (VaM) or vulvar melanoma (VuM) who were treated with immune checkpoint inhibitors (ICI) and discuss the development of immune-related adverse events (irAE).</p><p><strong>Materials and methods: </strong>This is a retrospective case series of patients diagnosed with VaM or VuM between July 2011 and September 2022 at the University of Virginia, Emily Couric Clinical Cancer Center. Patient demographics, disease characteristics, treatment outcomes, and adverse events were abstracted. The primary outcome was incidence of irAE.</p><p><strong>Results: </strong>Eight patients were included in this study, four with VaM and four with VuM. Most (<i>n</i> = 6) had local or regional disease at first presentation, and 25% (<i>n</i> = 2) presented with distant metastasis. All patients received a CTLA-4 inhibitor and 75% (<i>n</i> = 6) received PD-1 inhibitor alone or in combination with a CTLA-4 inhibitor. Most (75%, <i>n</i> = 6) patients experienced irAE. Of those who had irAE, 83% (<i>n</i> = 5) required therapy interruption or discontinuation. Most (66%, <i>n</i> = 4) underwent ICI rechallenge of which 75% (<i>n</i> = 3) experienced subsequent irAE. Of all patients in the series, 75% of patients (<i>n</i> = 6) had partial or complete response to ICI.</p><p><strong>Conclusion: </strong>This series is the first to detail incidence of irAEs and ICI rechallenges in vulvovaginal melanoma. Our findings indicate that while ICIs are effective, their use is associated with significant irAE development. Rechallenge of ICI after irAE is feasible but associated with risk of recurrent/new irAE. Further studies are needed to better quantify this risk.</p>","PeriodicalId":19439,"journal":{"name":"Obstetrics and Gynecology International","volume":"2024 ","pages":"7327692"},"PeriodicalIF":1.6,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11335409/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142009087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fatma Ceren Guner, Murat Ozekinci, Ibrahim Inanc Mendilcioglu, Zeliha Kasabali
{"title":"Reproductive Outcomes of Dual Trigger versus hCG Alone in Women Undergoing In Vitro Fertilization with Fresh Embryo Transfer Cycles.","authors":"Fatma Ceren Guner, Murat Ozekinci, Ibrahim Inanc Mendilcioglu, Zeliha Kasabali","doi":"10.1155/2024/9972437","DOIUrl":"10.1155/2024/9972437","url":null,"abstract":"<p><strong>Aim: </strong>To investigate the effect of the triggering method on the results of fresh embryo transfer in patients who underwent gonadotropin-releasing hormone antagonist cycles.</p><p><strong>Methods: </strong>The study was conducted retrospectively at a university-based tertiary reproductive center. The sample consisted of a total of 295 patients, of whom 111 were in the human chorionic gonadotropin (hCG) trigger group and 184 were in the dual trigger group. The main outcome measure of this study was the live birth rate, and secondary outcomes were the implantation rate, clinical pregnancy rate, miscarriage rate, and good-quality embryo rate.</p><p><strong>Results: </strong>Patient demographics and baseline characteristics did not significantly differ between the dual and hCG trigger groups. The results also indicated statistically nonsignificant differences between the two groups in terms of the number of oocytes retrieved (<i>p</i> > 0.05), the number of mature oocytes (<i>p</i> > 0.05), and the fertilization rate (<i>p</i> > 0.05). The number of good-quality embryos (<i>p</i>=0.002) was higher in the dual trigger group compared with the hCG trigger group. However, the rates of clinical pregnancy and live births did not significantly differ between the groups (<i>p</i> > 0.05).</p><p><strong>Conclusions: </strong>Although the number of total and high-quality embryos obtained was higher in the dual trigger group, there were no significant differences between the two groups in terms of pregnancy outcomes. The fresh embryo transfer yielded similar rates of implantation and live births in both trigger groups.</p>","PeriodicalId":19439,"journal":{"name":"Obstetrics and Gynecology International","volume":"2024 ","pages":"9972437"},"PeriodicalIF":1.6,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11251794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141627257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Postoperative Chylous Ascites in Gynecological Malignancies: Two Case Reports and a Literature Review.","authors":"Xin Tan, GuoLin Luo, Guangdong Liao, Hong Liao","doi":"10.1155/2024/1810634","DOIUrl":"10.1155/2024/1810634","url":null,"abstract":"<p><strong>Aim: </strong>To explore the potential factors that influence the presentation and recovery of postoperative chylous ascites (CA) in gynecological malignancies.</p><p><strong>Methods: </strong>We reported two cases of postoperative CA following gynecological surgery and reviewed the clinical features of 140 patients from 16 relevant papers. Patients' clinicopathological characteristics, surgical approach, and management were summarized. The onset and resolution times of postoperative CA in different groups were analyzed separately.</p><p><strong>Results: </strong>The two patients in our report had recovery after conservative treatments. According to the literature review, the median time of onset of postoperative CA was 5 days (range, 0-75 days) after surgery. The median resolution time was 9 days (range, 2-90 days). Among patients, 87.14% of them had lymphadenectomy during gynecological surgeries, while 92.86% of the patients had resolution after conservative treatments.</p><p><strong>Conclusions: </strong>Lymphadenectomy during surgery may be relevant to the postoperative CA. Conservative management could be the initial choice for postoperative CA treatment.</p>","PeriodicalId":19439,"journal":{"name":"Obstetrics and Gynecology International","volume":"2024 ","pages":"1810634"},"PeriodicalIF":1.6,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11219204/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141492892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"<i>β</i>-Human Chorionic Gonadotropin Dynamics in Early Gestational Events: A Practical and Updated Reappraisal.","authors":"Demetrio Larraín, Javier Caradeux","doi":"10.1155/2024/8351132","DOIUrl":"10.1155/2024/8351132","url":null,"abstract":"<p><p>In the last decade, the widespread use of transvaginal ultrasound and the availability of highly specific serum assays of human chorionic gonadotropin (hCG) have become mainstays in the evaluation of early pregnancy. These tests have revolutionized the management of pregnancies of unknown location and markedly reduced the morbidity and mortality associated with the misdiagnosis of ectopic pregnancy. However, despite several advances, their misuse and misinterpretations are still common, leading to an increased use of healthcare resources, patient misinformation, and anxiety. This narrative review aims to succinctly summarize the <i>β</i>-hCG dynamics in early gestation and provide general gynecologists a practical approach to patients with first-trimester symptomatic pregnancy.</p>","PeriodicalId":19439,"journal":{"name":"Obstetrics and Gynecology International","volume":"2024 ","pages":"8351132"},"PeriodicalIF":1.9,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10940029/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140132231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Melissa A Rodriguez, Roderick S Hooker, Kasey K Puckett, Andrzej Kozikowski
{"title":"Demographics of Physician Associates (PAs) in Obstetrics and Gynecology: Where They Work and How They Compare to Other PAs.","authors":"Melissa A Rodriguez, Roderick S Hooker, Kasey K Puckett, Andrzej Kozikowski","doi":"10.1155/2024/3057597","DOIUrl":"10.1155/2024/3057597","url":null,"abstract":"<p><p>As of 2020, maternal and infant health in the US has worsened. At the same time, the number of health professionals available to manage female health issues is changing; the number of physicians in obstetrics and gynecology (Ob-Gyn) and midwives is decreasing, whereas the number of Ob-Gyn physician associates (PAs) is growing. We analyzed PAs practicing in the Ob-Gyn discipline, drawing on the PA Professional Profile, a database maintained by the National Commission on Certification of PAs. In 2021, there were 1,322 Ob-Gyn PAs (1.2% of all clinically active PAs). This health profession has grown by 66.9% since 2013, when only 792 PAs practiced in this specialty. As of 2021, their median age was 38, and 98.0% were female (70.1% of all PAs were female). The practice setting was between office (54.7%) and hospital (34.0%) employment, with 11.3% described as \"other.\" In 2021, the median annual income of Ob-Gyn PAs was $105,000. With the reduction of obstetrician-gynecologists, the relative growth of PAs in this area of medicine and surgery is a natural part of the solution to the projected obstetrical physician deficit.</p>","PeriodicalId":19439,"journal":{"name":"Obstetrics and Gynecology International","volume":"2024 ","pages":"3057597"},"PeriodicalIF":1.9,"publicationDate":"2024-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10901571/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139990783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kemas Yusuf Effendi, Excellena Nasrul, Iskandar Zulqarnain, Theodorus, Rizani Amran, Heriyadi Manan, Adnan Abadi, Fatimah Usman, Cindy Kesty
{"title":"Diagnostic Test of <i>Transforming Growth Factor-Beta</i> 1 (TGF-<i>β</i>1) in Menstrual Blood with Endometriosis.","authors":"Kemas Yusuf Effendi, Excellena Nasrul, Iskandar Zulqarnain, Theodorus, Rizani Amran, Heriyadi Manan, Adnan Abadi, Fatimah Usman, Cindy Kesty","doi":"10.1155/2023/9970818","DOIUrl":"10.1155/2023/9970818","url":null,"abstract":"<p><strong>Background: </strong>Endometriosis is a benign disorder that is generally defined as the presence of endometrial glands and stroma outside their normal location. TGF-<i>β</i>1 is found in stromal cells and its expression is increased in epithelial cells of endometriotic cysts. Endometriosis diagnostics take a long time, so new markers are needed to diagnose endometriosis. This study aims to determine the diagnostic value of TGF-<i>β</i>1 in menstrual blood in diagnosing endometriosis.</p><p><strong>Method: </strong>Diagnostic tests to compare eutopic endometrial TGF-<i>β</i>1 levels from menstrual blood of patients with suspected endometriosis were undertaken in the Obstetrics and Gynecology Department of Dr. Mohammad Hoesin General Hospital, Faculty of Medicine, Sriwijaya University, Palembang, from July 2019 to November 2020. 50 patients who were suspected with endometriosis met the inclusion criteria. Comparison of TGF-<i>β</i>1 levels between endometriosis and nonendometriosis patients was analyzed using the Mann-Whitney test. The cutoff point of the TGF-<i>β</i>1 level towards the histopathological outcome was obtained using the ROC curve. Data analysis was performed by using SPSS version 22.0.</p><p><strong>Results: </strong>In this study, endometriosis patients were 31.6 ± 6.55 years of age with a range of 20 to 46 years. In statistical analysis, there was no difference in BMI (<i>p</i> = 0.181) and BMI classification (<i>p</i> = 0.207), the history of contraception (<i>p</i> = 0.097), infertility (<i>p</i> = 1.000), and dysmenorrhoea (<i>p</i> = 1.000) between endometriosis and nonendometriosis patients. In the study, there were differences in TGF-<i>β</i>1 between endometriosis and nonendometriosis patients (<i>p</i> ≤ 0.001). By using the ROC curve, the cutoff point for TGF-<i>β</i>1 levels has the best sensitivity and specificity, which is 515 ng/ml. The TGF-<i>β</i>1 level has a sensitivity of 80%, a specificity of 90%, a positive predictive value (PPV) of 0.969, a negative predictive value (NPV) of 0.529, a positive likelihood ratio of 8, a negative likelihood ratio of 0.222, and an accuracy of 0.820 to the endometriosis outcome.</p><p><strong>Conclusion: </strong>It can be concluded that the TGF-<i>β</i>1 level has a very good diagnostic value in establishing endometriosis diagnostics. This trial is registered with ISRCTN72218532.</p>","PeriodicalId":19439,"journal":{"name":"Obstetrics and Gynecology International","volume":"2023 ","pages":"9970818"},"PeriodicalIF":1.9,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10728358/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138797674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Melatonin Ameliorates Ovarian Hyperstimulation Syndrome (OHSS) through SESN2 Regulated Antiapoptosis.","authors":"Min Zheng, Mei Liu, Cong Zhang","doi":"10.1155/2023/1121227","DOIUrl":"10.1155/2023/1121227","url":null,"abstract":"<p><strong>Background: </strong>Ovarian hyperstimulation syndrome (OHSS) is one of the most severe complications after ovarian stimulation during assisted reproductive technology (ART). However, its pathogenesis still remains unclear. Melatonin is an important antioxidant factor in female reproduction and Sestrin-2 (SESN2) is reported to be involved in cellular response to different stress conditions. Whether or not melatonin and SESN2 are involved in OHSS is still a question to us clinicians.</p><p><strong>Methods and results: </strong>We collected the granulosa cells of OHSS patients and focused on the role of SESN2 in OHSS. We also studied the role and mechanism of melatonin plays in OHSS patients. We found that the expression of SESN2 was increased in the granulosa cells of OHSS patients (<i>n</i> = 24) than those in controls (<i>n</i> = 15). Incubation with angiotensin II (1 <i>μ</i>M, 2 <i>μ</i>M) in HUVECs and H2O2 (0.1 mM, 0.2 mM) in KGNs increased the generation of ROS concurrent with the increased expression of SESN2, while melatonin treatment partly restored SESN2 levels. The mechanism study demonstrated that SESN2 was deeply involved in the regulation of AMPK and mTOR, whereas melatonin partially restored angiotensin II or H2O2 induced the activation of AMPK phosphorylation and the inhibition of mTOR, 4EBP1 and S6K1 phosphorylation, all of which could trigger cell apoptosis.</p><p><strong>Conclusions: </strong>These findings indicated that melatonin attenuated ROS-induced apoptosis through SESN2-AMPK-mTOR in OHSS. Thus, melatonin is likely to be a potential and important therapeutic agent for treating and preventing OHSS.</p>","PeriodicalId":19439,"journal":{"name":"Obstetrics and Gynecology International","volume":"2023 ","pages":"1121227"},"PeriodicalIF":1.9,"publicationDate":"2023-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10626722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71484512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparing Surgical and Oncological Outcomes between Indocyanine Green (ICG) Sentinel Lymph Node Mapping with Routine Lymphadenectomy in the Surgical Staging of Early-Stage Endometrioid Endometrial Cancer.","authors":"Krystal Miao Lin Koh, Zheng Yuan Ng, Felicia Hui Xian Chin, Wai Loong Wong, Junjie Wang, Yong Kuei Lim","doi":"10.1155/2023/9949604","DOIUrl":"10.1155/2023/9949604","url":null,"abstract":"<p><strong>Methods: </strong>A retrospective single-centre cohort study of patients with early-stage endometrioid endometrial cancer undergoing staging surgery (total hysterectomy, bilateral salpingo-oophorectomy with/without pelvic lymph node, and/or para-aortic lymph node dissection (PLND)) with either SLN mapping or routine lymphadenectomy between July 2017 and December 2018.</p><p><strong>Results: </strong>203 cases with clinical and radiological International Federation of Gynaecology and Obstetrics (FIGO) stage I endometrioid endometrial cancer were included, out of which 109 cases underwent SLN mapping and 94 cases complete lymphadenectomy. Compared to the PLND group, the SLN group had shorter operative time (129 vs. 162 minutes), less blood loss (100 vs. 300 ml), and decreased length of postoperative hospital stay (3 vs. 4 days) (<i>p</i> < 0.001). The lymph node metastases detection rate was 4.6% and 7.4% for the SLN and PLND groups, respectively (<i>p</i> = 0.389). With a median follow-up of 14 months for the SLN and 15 months for the PLND group, the disease-free (DFS) and overall survival (OS) were comparable for both at 13 months (<i>p</i> = 0.538 and <i>p</i> = 0.333, respectively).</p><p><strong>Conclusion: </strong>SLN mapping has been shown to be an acceptable alternative to routine lymphadenectomy in the surgical staging of early-stage endometrial cancer in our centre, with a comparable lymph node metastases detection rate, DFS and OS, and reduction in operative morbidity. Our results with SLN mapping reproduce comparable outcomes to those reported in the literature.</p>","PeriodicalId":19439,"journal":{"name":"Obstetrics and Gynecology International","volume":"2023 ","pages":"9949604"},"PeriodicalIF":1.9,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10597725/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50162381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pregnancies in Women with a Previous Complete Uterine Rupture.","authors":"Iqbal Al-Zirqi, Siri Vangen","doi":"10.1155/2023/9056489","DOIUrl":"10.1155/2023/9056489","url":null,"abstract":"<p><strong>Objective: </strong>To study the outcomes of new pregnancies after a previous complete uterine rupture.</p><p><strong>Design: </strong>Descriptive study based on population data from the Medical Birth Registry of Norway, the Patient Administration System, and the medical records. <i>Sample</i>. Maternities with a previous complete uterine rupture in Norway during the period 1967-2011 (<i>N</i> = 72), extracted from 2 455 797 maternities.</p><p><strong>Method: </strong>We measured the rate of new complete ruptures and partial ruptures, as well as the maternal and perinatal outcomes of these pregnancies. The characteristics of both previous ruptures and new ruptures were described.</p><p><strong>Results: </strong>Among 72 maternities, there were thirty-seven with previous ruptures in the lower segment (LS) and 35 outside the LS. We found three new complete ruptures and six uneventful partial ruptures, resulting in a rate of 4.2% and 8.3%, respectively. All three complete ruptures occurred preterm in scars outside the LS. The rate of the new complete rupture was 0% in those with previous ruptures in the LS and 8.6% in those with previous ruptures outside the LS. The corrected perinatal mortality was 1.3%, and prematurity (<37 weeks) was high (36.1%); this was noticed even in the absence of new ruptures and was mostly iatrogenic. Two hysterectomies were performed in the absence of rupture and two cases had abnormal invasive placenta.</p><p><strong>Conclusion: </strong>The prognosis for pregnancies after a previous complete uterine rupture is favorable. Prematurity is a problem caused by both obstetrician and mother's anxiety; therefore, the timing of delivery is the most challenging. Management should include careful counseling, vigilance for symptoms, and immediate delivery when a rupture is suspected.</p>","PeriodicalId":19439,"journal":{"name":"Obstetrics and Gynecology International","volume":"2023 ","pages":"9056489"},"PeriodicalIF":1.6,"publicationDate":"2023-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9935781/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10826747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abubakari Wuni, Brenda Abena Nyarko, Mudasir Mohammed Ibrahim, Issahaka Abdulai Baako, Iddrisu Sisala Mohammed, Camillus Buunaaisie
{"title":"Prevalence, Management, and Impact of Dysmenorrhea on the Lives of Nurse and Midwife Trainees in Northern Ghana.","authors":"Abubakari Wuni, Brenda Abena Nyarko, Mudasir Mohammed Ibrahim, Issahaka Abdulai Baako, Iddrisu Sisala Mohammed, Camillus Buunaaisie","doi":"10.1155/2023/8823525","DOIUrl":"https://doi.org/10.1155/2023/8823525","url":null,"abstract":"<p><strong>Background: </strong>Dysmenorrhea is the most common gynecological problem affecting the majority of female students in the nursing profession today. They often experience severe pain that is not only incapacitating but also has a significant impact on their day-to-day college life, academic, and clinical performance.</p><p><strong>Aim: </strong>This study was conducted to assess the prevalence, management, and impact of dysmenorrhea on the lives of nurse and midwife trainees in northern Ghana.</p><p><strong>Methods: </strong>A descriptive cross-sectional design with a quantitative approach to data collection was employed to collect data from nurse and midwife trainees in three colleges of nursing and/or midwifery in the northern region of Ghana. A proportionate stratified random sampling technique was used to recruit 303 respondents for the study. After gaining permission from various institutions, data were collected by using a structured questionnaire from 13<sup>th</sup> September to 28<sup>th</sup> October, 2022. Stata (special edition) for Windows version 17.0 was used for the statistical analyses.</p><p><strong>Results: </strong>The study revealed a high prevalence of dysmenorrhea among female nursing students (66.7% and 95% CI: 0.611-0.720). More than half of the respondents (67.3%) experienced loss of appetite for food. The most common site of most intense pain was the pelvis and lower abdomen (98.0%). A greater proportion of students (65.8%) used antispastic drugs to reduce pain. The respondents' concentration in the classroom was greatly affected (77.2%) as well as normal physical activities (58.4%). A multivariable logistic regression analysis revealed that the odds of dysmenorrhea are 2.67 times higher when the duration of menstruation is 4-5 days (AOR = 1.82, 95% CI = 1.13-6.28, and <i>p</i> = 0.024) than a duration of 1-3 days. Having urinary tract infections was associated with 3.56 times higher odds of dysmenorrhea (AOR = 3.56, 95% CI = 0.98-12.86, and <i>p</i> = 0.053). Again, the odds of dysmenorrhea were also four times higher among respondents with a family history of the same condition (AOR = 4.05, 95% CI = 2.16-7.61, and <i>p</i> = 0.001).</p><p><strong>Conclusion: </strong>The current study revealed a high prevalence of dysmenorrhea among nurse and midwife trainees in the northern part of Ghana. The majority of the respondent experienced loss of appetite and intense pain in the pelvis and lower abdomen, and their concentration during lectures was also significantly affected. The most predominant nonpharmacological method used for reducing the pain was sleep and the application of warm objects on the abdomen.</p>","PeriodicalId":19439,"journal":{"name":"Obstetrics and Gynecology International","volume":"2023 ","pages":"8823525"},"PeriodicalIF":1.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10442185/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10413885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}