Nigerian Journal of Clinical Practice最新文献

{"title":"Application of Case-Based Learning Combined with PDCA in the Training of Grassroot Surgeons for the Updates in the CSCO Guidelines for the Diagnosis and Treatment of Breast (2023).","authors":"J Li, G Hu, G Zhao","doi":"10.4103/njcp.njcp_161_24","DOIUrl":"10.4103/njcp.njcp_161_24","url":null,"abstract":"<p><strong>Background: </strong>In county-level hospitals in China, there is a need to enhance the understanding and implementation of the updates in the Guidelines for the Diagnosis and Treatment of Breast Cancer.</p><p><strong>Aims: </strong>The aim of this study was to evaluate the effectiveness of case-based learning (CBL) integrated with the PDCA (Plan-Do-Check-Act) cycle in improving the knowledge and skills of surgeons related to the most recent Chinese Society of Clinical Oncology (CSCO) Guidelines for the Diagnosis and Treatment of Breast Cancer. Eighty surgeons from county-level hospitals were recruited and randomly assigned to two groups for a comparative study: one experiencing CBL alone and the other receiving CBL combined with the PDCA cycle.</p><p><strong>Methods: </strong>Participants in both groups underwent a 5-day breast cancer therapeutic strategy course. The effectiveness of these methodologies was assessed using pretraining and post-training tests, examinations, and a satisfaction questionnaire. Statistical analysis was conducted to compare the knowledge gains between the two groups using pretraining and post-training assessment scores, with the significance level set at P < 0.05.</p><p><strong>Results: </strong>Both instructional methods resulted in knowledge improvement, but the group that received CBL with PDCA demonstrated significantly higher scores on post-training tests, particularly regarding updates in guidelines (80% vs 76%, P = 0.002) and accuracy in case-based therapeutic plans (92% vs 83%, P < 0.001).</p><p><strong>Conclusion: </strong>The study concludes that the integration of the PDCA cycle with CBL significantly enhances the surgeons' acquisition and application of updated therapeutic knowledge and skills for breast cancer.</p>","PeriodicalId":19431,"journal":{"name":"Nigerian Journal of Clinical Practice","volume":"28 5","pages":"666-671"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adopting Virtual Reality in Medical Education: Insights from Clinical Students and Lecturers in a Nigerian University.","authors":"O D Otuyemi, O A Ijarotimi, A O Komolafe, S B Aregbesola, O M Adetutu, O B Akinwale, B A Kolawole, O A Okunola, A O Oluwatope, O Abiona, A T Ayinde, L Idowu, O M Agunbiade, A A Adediwura","doi":"10.4103/njcp.njcp_739_24","DOIUrl":"https://doi.org/10.4103/njcp.njcp_739_24","url":null,"abstract":"<p><strong>Background: </strong>The application of virtual reality (VR) in medical education has steadily increased over the years in advanced countries, but its uptake has been low in low- and middle-income countries.</p><p><strong>Aim: </strong>This study explored the feasibility, acceptability, and appropriateness of VR in clinical training/assessment among Nigerian students of Dentistry, Medicine/Surgery, Nursing, and their clinical lecturers.</p><p><strong>Materials and methods: </strong>A cross-sectional study was carried out among 237 clinical students and 71 clinical lecturers enrolled in three Health Sciences Programs at a Nigerian university. Their perceptions were assessed using a structured online questionnaire mailed to students and lecturers' platforms.</p><p><strong>Results: </strong>The age of respondents ranged from 20 to 68 years and were predominantly female gender (56.8%). The majority (91.3%) of respondents judged the model as acceptable, 90.0% acceded to the appropriateness of VR, while 89.3% agreed to its feasibility in medical education. The academic program was significantly associated with acceptability and feasibility of VR for teaching and clinical examination, with dentistry having the highest proportion of ratings across the three domains of outcomes (P < 0.05). Age was significantly associated with the feasibility of VR, with more appeal from younger trainees and trainers (P < 0.05). The medicine/surgery students were less enthusiastic about the appropriateness of VR for teaching and clinical examinations.</p><p><strong>Conclusion: </strong>The use of VR for training and assessment in undergraduate medical education was rated high in terms of its acceptability, appropriateness, and feasibility (>80%). This innovation was more appealing to younger trainees and trainers.</p>","PeriodicalId":19431,"journal":{"name":"Nigerian Journal of Clinical Practice","volume":"28 5","pages":"582-589"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does Breastfeeding Education Influence the Breastfeeding Attitudes of Mothers with Children Suffering from Diarrhea?","authors":"B Gunes, Hy Sevinç Akın, B Akın","doi":"10.4103/njcp.njcp_891_24","DOIUrl":"https://doi.org/10.4103/njcp.njcp_891_24","url":null,"abstract":"<p><strong>Background: </strong>Diarrhea is more frequent stooling than is normal for an individual. It is one of the leading causes of death among children under the age of five.</p><p><strong>Aim: </strong>This study aims to evaluate the impact of breastfeeding education on the attitudes of mothers toward breastfeeding, particularly in the context of caring for children with diarrhea.</p><p><strong>Patients and methods: </strong>The study employed a pre-test/post-test intervention design with both experimental and control groups. Data were collected from mothers of infants aged 0-2 years who were undergoing treatment for diarrhea, by using a Demographic Information Form and the Iowa Infant Feeding Attitude Scale. A total of 90 mothers participated, with 45 assigned to the education group and 45 to the control group.</p><p><strong>Results: </strong>The study revealed that 7.8% of the infants had never been breastfed, while 52.2% were currently receiving breast milk. Furthermore, 75.6% of the infants had experienced diarrhea within the past month, and 53.3% had a prior history of diarrhea. Notably, 3.3% of the mothers discontinued breastfeeding during their child's diarrheal episode. A statistically significant difference was observed between the pre-test and post-test scores of mothers in the education group, indicating a marked improvement in breastfeeding attitudes following the educational intervention (P < 0.001).</p><p><strong>Conclusion: </strong>Breastfeeding education significantly improves mothers' attitudes, particularly in the context of diarrhea. Educating mothers on the role of breastfeeding in preventing life-threatening conditions such as diarrhea is crucial for child health. Therefore, targeted breastfeeding education programs should be prioritized in pediatric health promotion.</p>","PeriodicalId":19431,"journal":{"name":"Nigerian Journal of Clinical Practice","volume":"28 5","pages":"658-665"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the Relationship between Patient Satisfaction and Self-Esteem in Primary Rhinoplasty.","authors":"M A Say, S Kul, S İpek Şenyiğit","doi":"10.4103/njcp.njcp_835_24","DOIUrl":"https://doi.org/10.4103/njcp.njcp_835_24","url":null,"abstract":"<p><strong>Background: </strong>High self-esteem is believed to be critical for achieving success in work and education; therefore, it is important to promote self-esteem and prevent low self-esteem. Aesthetic procedures such as rhinoplasty can maintain and improve self-esteem by maintaining a positive self-image.</p><p><strong>Aim: </strong>To determine whether primary rhinoplasty can improve self-esteem in patients and investigate the relationship between self-esteem improvement and patient satisfaction after surgery.</p><p><strong>Methods: </strong>Patients who underwent primary rhinoplasty surgery were included in this study. The Rhinoplasty Outcome Evaluation (ROE) questionnaire was administered preoperatively and one year after the operation to assess participant satisfaction. The Rosenberg Self-Esteem Scale was administered preoperatively and 1 year after the operation to assess self-esteem.</p><p><strong>Results: </strong>In total, 88 patients were included in this study. A significant difference was found between their preoperative and postoperative ROE scores (P < .05). Similarly, a significant difference was observed between their preoperative and postoperative Rosenberg scores (P < .05). The patients were divided into low satisfaction and high satisfaction groups: those with ROE percentage scores of >85% and those with ROE percentage scores of <85%. A statistically significant difference was found between the low and high satisfaction groups in terms of preoperative and postoperative Rosenberg scores (P < .05). The Rosenberg scores of the low satisfaction group were significantly lower.</p><p><strong>Conclusions: </strong>Rhinoplasty can improve self-esteem in patients, suggesting that it has a positive effect on the mental health of the community along with social benefits and evaluation of preoperative patients' self-esteem guides surgeons in predicting postoperative rhinoplasty results.</p>","PeriodicalId":19431,"journal":{"name":"Nigerian Journal of Clinical Practice","volume":"28 5","pages":"654-657"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic Inflammatory Response Index in Cervical Pathologies (Human Papillomavirus and Cervical Neoplasia) and its Prognostic Value in Disease Prediction.","authors":"N Cim, E Ayguler, N Gunal, B Cim, H Argun Atalmis, A Cetin","doi":"10.4103/njcp.njcp_581_24","DOIUrl":"https://doi.org/10.4103/njcp.njcp_581_24","url":null,"abstract":"<p><strong>Background: </strong>Cervical pathologies, from chronic cervicitis to cervical cancer, are a global public health issue. Inflammation is crucial to these disorders' development. The systemic inflammatory response may predict cancer and chronic inflammatory disease outcomes.</p><p><strong>Aim: </strong>This study aimed to determine the importance of systemic inflammatory response indicators in human papillomavirus (HPV) infection and cervical pathologies.</p><p><strong>Methods: </strong>In this retrospective analysis, pap smear, HPV, cervical biopsy, complete blood count (CBC) parameters, and systemic inflammatory response index (SIRI) of women who underwent gynecological examination were evaluated.</p><p><strong>Results: </strong>The study included 452 women. Mean platelet volume (MPV) was comparable in HPV other high-risk positive and negative women but lower in HPV Type-16/18 positive women (P < 0.001). Neutrophil/lymphocyte ratio, lymphocyte/monocyte ratio, eosinophil/lymphocyte ratio (ELR), platelet/lymphocyte ratio (PLR), systemic inflammatory index [SII (platelet × neutrophil/lymphocyte)], and SIRI (neutrophil × monocyte/lymphocyte) were also similar (P > 0.05). Low-grade intraepithelial lesion (LSIL) women have lower ages and pregnancies at pap smear (P < 0.05). The high-grade intraepithelial lesion (HSIL) group showed greater platelet (PLT) counts and decreased MPV than the other groups (P < 0.05). The LSIL group had considerably reduced eosinophil counts (P < 0.05). ELR was lower in the LSIL group (P = 0.004). PLR was the highest for HSIL and lowest for LSIL (P = 0.002). The SII was highest in the HSIL group and lowest in the LSIL group (P = 0.008). PLT and MPV were lower in the cervical biopsy-classified women than in the other cervical pathology and control groups (P = 0.03 and 0.001, respectively).</p><p><strong>Conclusion: </strong>We found a link between the mean PLT volume and HPV-related cervical disease.</p>","PeriodicalId":19431,"journal":{"name":"Nigerian Journal of Clinical Practice","volume":"28 5","pages":"615-623"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antithrombotic Effect of Ginkgo Biloba Extract: A Study Based on Network Pharmacological Analysis and In vivo Experiments.","authors":"H Yang, H Yang, W Ma, K Yang, J Liao, Y Zhao","doi":"10.4103/njcp.njcp_770_24","DOIUrl":"https://doi.org/10.4103/njcp.njcp_770_24","url":null,"abstract":"<p><strong>Background and aims: </strong>Thrombosis is a major contributor to cardiovascular and cerebrovascular diseases. Despite the availability of anticoagulants and thrombolytic agents, their clinical use is often limited by adverse effects. Ginkgo biloba extract (GbE), a traditional herbal medicine, has shown promise in alleviating thrombosis, but its underlying mechanisms remain insufficiently understood. This study aimed to explore the antithrombotic effects and molecular mechanisms of GbE through network pharmacology and in vivo experiments.</p><p><strong>Methods: </strong>Online databases were utilized for identifying the GbE's active components and target genes, accompanied by thrombosis-related targets. Functional enrichment analyses, including Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analysis, were performed. A drug-active component-target gene-signaling pathway network and a protein-protein interaction (PPI) network were constructed to determine core target genes and pathways. In vivo, a deep vein thrombosis (DVT) model was established by ligating the inferior vena cava in male Sprague-Dawley rats. Hematoxylin and eosin staining was adopted for evaluating the vascular endothelial structure. The levels of cyclic guanosine monophosphate (cGMP), prostaglandin I2 (PGI2), nitric oxide (NO), and fibrinogen (FIB) were measured, accompanied by the activated partial thromboplastin time (APTT), thrombin time (TT), and prothrombin time (PT). Western blot analysis was performed to examine the PI3K/AKT pathway-related protein expression.</p><p><strong>Results: </strong>GbE comprised 27 active components with 4727 target genes and 2462 thrombosis-related targets, with 974 shared targets, including AKT1, ALB, GAPDH, TNF, and IL6, enriched in PI3K-AKT and AGE-RAGE pathways. Molecular docking indicated strong binding of GbE's main components to core targets. In vivo, GbE significantly relieved vascular lesions of DVT rats; reduced thrombotic wet weight; increased NO, cGMP, and PGI2 levels; decreased FIB; and prolonged APTT, PT, and TT (P < 0.05). Additionally, Western blot highlighted the suppressed p-PI3K/PI3K and p-AKT/AKT ratios in DVT rats.</p><p><strong>Conclusions: </strong>GbE alleviates thrombosis by increasing antithrombotic factors and reducing coagulation, potentially via downregulating the PI3K/AKT signaling. Future studies should focus on long-term clinical trials and broader animal models to further validate GbE's therapeutic potential and explore other molecular mechanisms.</p>","PeriodicalId":19431,"journal":{"name":"Nigerian Journal of Clinical Practice","volume":"28 5","pages":"624-632"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-Vitro Comparison of Screw Loosening, Fracture Strength and Failure Mode of Implant-Supported Hybrid-Abutment Crowns and Screwmentable Crowns Manufactured with Different Materials.","authors":"I Çötert, M Ulusoy, A G Türk","doi":"10.4103/njcp.njcp_772_23","DOIUrl":"https://doi.org/10.4103/njcp.njcp_772_23","url":null,"abstract":"<p><strong>Background: </strong>Hybrid-abutment crowns and screwmentable crowns offer a fusion of the benefits from both screw and cement-retained restorations, potentially enhancing the overall performance of the restoration.</p><p><strong>Aim: </strong>This study aimed to evaluate the screw loosening and fracture strength of hybrid-abutment crowns and screwmentable crowns made with two different materials.</p><p><strong>Methods: </strong>Forty single-crown were made on titanium implants and divided into four groups (n = 10) [SM-Ti: Screwmentable titanium-porcelain crowns on stock titanium abutment; SM-Zr: Screwmentable zirconia-porcelain crowns on stock zirconia abutment; AC-Ti: Titanium-porcelain abutment crowns; AC-Zr: Zirconia-porcelain abutment crowns.] Specimens were torqued with 30 NCm and thermocycled between 5℃ and 55℃ in 20-second cycles for 5000 cycles. Removal torque values (RTV) were measured. Following the RTV measurement, the screws were changed with fresh screws and torqued again. Afterwards, specimens were loaded to fracture and fracture strengths were recorded, failure modes were examined.</p><p><strong>Statistical analysis used: </strong>Analysis of variance and Bonferroni test was performed.</p><p><strong>Results: </strong>The AC-Ti group displayed the highest mean torque loss (%20.09 ± 6.49) and the SM-Ti group displayed the lowest (%9.59 ± 8.84). Only the difference between AC-Ti and SM-Ti groups was found statistically significant, there are no significant differences between other groups. The fracture strengths are 385.84 ± 27.68 N, 313.18 ± 39.97 N, 272.69 ± 35.03 N, and 156.71 ± 19.83 N for AC-Ti, AC-Zr, SM-Ti, and SM-Zr groups, respectively and all differences were found to be statistically significant. Failures occurred as deformation in titanium components, whereas fractures were observed in zirconia components.</p><p><strong>Conclusion: </strong>Screw loosening was observed only in the AC-Ti group. No significant difference was observed among the torque loss values in the remaining groups. Titanium and zirconia materials do not exert any influence on screw loosening after thermal aging for hybrid-abutment crowns. Moreover, when assessing fracture strength, hybrid-abutment crowns exhibit superior strength and durability compared to screwmentable crowns.</p>","PeriodicalId":19431,"journal":{"name":"Nigerian Journal of Clinical Practice","volume":"28 4","pages":"461-470"},"PeriodicalIF":0.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144006548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of Exercise Capacity in Children and Adolescents with Asthma: A Comparative Case-Control Study.","authors":"M Kaya, H Ucgun, B G Karaaslan, A Kiykim, H D Kulli","doi":"10.4103/njcp.njcp_746_24","DOIUrl":"https://doi.org/10.4103/njcp.njcp_746_24","url":null,"abstract":"<p><strong>Background: </strong>Asthma is a chronic disease that may affect exercise capacity. Despite the variety of existing tools for assessing exercise capacity, whether patients with asthma have lower exercise capacity than healthy controls and its potential determinants are still poorly understood.</p><p><strong>Aim: </strong>The primary aim of this study was to identify potential determinants of exercise capacity. The secondary aim was to compare exercise capacity, pulmonary function, and muscle strength of children and adolescents with asthma with healthy controls.</p><p><strong>Methods: </strong>Volunteers aged 7-17 participated in the study and were divided into two groups: the asthma (n = 60) and the healthy control (n = 40). Asthma control questionnaire, six-minute walk test, pulmonary function test, maximum inspiratory (MIP) and expiratory (MEP) pressure measurements, and 30-second sit-to-stand test (30-STST) were performed.</p><p><strong>Results: </strong>The study showed that exercise capacity and respiratory and peripheral muscle strength were significantly lower compared to controls (P < 0.001, P = 0.031, P = 0.001, P = 0.025, respectively). Another critical finding was MIP, 30-STST, and MEP were the determinants of exercise capacity in children with asthma (R2 = 0.403, P < 0.001).</p><p><strong>Conclusion: </strong>Clinicians should not ignore that exercise capacity may be reduced in children and adolescents with asthma and add assessment and training of respiratory and peripheral muscle strength in pulmonary rehabilitation programs.</p>","PeriodicalId":19431,"journal":{"name":"Nigerian Journal of Clinical Practice","volume":"28 4","pages":"531-538"},"PeriodicalIF":0.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144023454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance of Serum Neutrophil-Gelatinase Associated Lipocalin (NGAL) in the Diagnosis of Pregnancy-Related Acute Kidney Injury (PRAKI) in Delta, State Nigeria: A Prospective Study.","authors":"E P Orhewere, A B Odonmeta, O A Adejumo, O C Okoye","doi":"10.4103/njcp.njcp_326_24","DOIUrl":"https://doi.org/10.4103/njcp.njcp_326_24","url":null,"abstract":"<p><strong>Background: </strong>Pregnancy-related acute kidney injury (PRAKI) is associated with poor maternal and perinatal outcomes if not promptly recognized. Diagnosis of PRAKI is currently based on serum creatinine, which delays diagnosis and, inevitably, treatment.</p><p><strong>Aims: </strong>To determine the performance of serum NGAL in the diagnosis of PRAKI among women in the peripartum period and determine the normal serum NGAL levels in nonpregnant women.</p><p><strong>Methods: </strong>A prospective study involving 162 pregnant women who presented in labor in two hospitals in Delta State and 150 nonpregnant controls. Serum creatinine and NGAL were assayed using blood samples collected from study participant at 0, 6, 12, 24, and 48 hours and 7 days postdelivery. Diagnosis of PRAKI was based on both serum creatinine and NGAL. The diagnostic performance of NGAL was determined by performing a receiver operation curve and determining the area under the curve (AUC).</p><p><strong>Results: </strong>The prevalence of AKI using creatinine-based KDIGO criteria was 22.2% and 50% using serum NGAL. The optimal diagnostic accuracy for serum NGAL was at the 12th hour, using a cut off of 142 ng/dl determined by Youden's index. The reference range for nonpregnant women was 12.77 - 135.67 ng/dl. The sensitivity and specificity of serum NGAL at a cut off 142 ng/ml were 77.2% and 75.4% (AUC = 0.79), respectively while using 135.67 ng/ml (upper limit determined from nonpregnant women) as cut-off, sensitivity was 77.78% and specificity was 70.63%.</p><p><strong>Conclusion: </strong>Serum NGAL is a promising marker for early diagnosis of PRAKI with high sensitivity and specificity.</p>","PeriodicalId":19431,"journal":{"name":"Nigerian Journal of Clinical Practice","volume":"28 4","pages":"525-530"},"PeriodicalIF":0.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of \"Oral Administration of Breast Milk Droplets\" and \"Palatal Stimulation with a Finger\" Methods on Feed Tolerance in Preterm Newborns Fed via an Orogastric Tube: Randomized Controlled Trial.","authors":"C Tunç, A Kokcu Dogan","doi":"10.4103/njcp.njcp_558_24","DOIUrl":"https://doi.org/10.4103/njcp.njcp_558_24","url":null,"abstract":"<p><strong>Background: </strong>Infants should be provided with effective feeding skills with evidence-based care practices to ensure nutritional tolerance and maximize the growth and development in preterm infants.</p><p><strong>Aim: </strong>This study aimed to examine the effects of \"oral administration of breast milk droplets\" and \"palatal stimulation with a finger\" methods on feed tolerance in preterm newborns fed via an orogastric tube.</p><p><strong>Methods: </strong>This randomized controlled trial was conducted in the neonatal intensive care unit of a private hospital. The study included 90 premature newborns born at the 28th-36th gestational weeks and admitted to intensive care. We applied breast milk droplets inside the oral cavity of newborns (30) in one of the intervention groups and stimulated the palate of newborns (30) by using a finger in the other. We performed these interventions every 3 hours for 5 minutes at the feeding times of the newborns for 7 days. Babies in the control group were not applied any intervention. We used SPSS (Statistical Package for Social Sciences) 22.0 for Windows software for statistical analyses.</p><p><strong>Results: </strong>The number of defecations, frequencies of residuals, body weight, and abdominal circumference were significantly different between the groups (P < 0.05). The increments in body weight and reductions in abdominal circumference were significantly different between the groups in the study (P < 0.05).</p><p><strong>Conclusion: </strong>Palatal stimulation with a finger acted on feed tolerance more favorably than the oral administration of breast milk droplets or no intervention in preterm infants fed via OGT. We suggest primarily that palatal stimulation with a finger and secondarily the oral administration of breast milk droplets as the two methods to be employed to overcome feeding intolerance, which is a significant problem in premature infants.</p>","PeriodicalId":19431,"journal":{"name":"Nigerian Journal of Clinical Practice","volume":"28 4","pages":"452-460"},"PeriodicalIF":0.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144006288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}