Nigerian Journal of Clinical Practice最新文献

{"title":"Unusual Association of 46XY/45XO Mosaic Turner Syndrome and Mullerian Agenesis.","authors":"M U Ibekwe, C G Ogbonna-Nwosu, L N Nwokeji-Onwe","doi":"10.4103/njcp.njcp_274_24","DOIUrl":"https://doi.org/10.4103/njcp.njcp_274_24","url":null,"abstract":"<p><p>Gonadal dysgenesis and Müllerian agenesis are rare congenital developmental disorders that are known to cause primary amenorrhea. They occur in approximately 1 in 2500 live births and in 1 in 4500-5000 females. We report a case of a 17-year-old girl who presented to our clinic on account of short stature and primary amenorrhea. Investigations revealed hypergonadotropic hypogonadism and absent ovaries uterus, upper part of the vagina, and right kidney on imaging. The karyotype showed 46, XY [12]/45, X[20] (mosaic Turner syndrome). The rare association of 46XY/45X mosaicism and Mullerian agenesis has significant clinical implications due to its known effects on growth and development, hormonal balance, reproductive capability, cultural implications, and psychological well-being.</p>","PeriodicalId":19431,"journal":{"name":"Nigerian Journal of Clinical Practice","volume":"28 5","pages":"672-676"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extranodal Nasal-Type NK/T-Cell Lymphoma Treatment: Analysis from a Multicenter Study.","authors":"D Sahin, N Soyer, M Yeral, S Namdaroglu, F Hindilerden, I Aydogdu, Hba Ozturk, B Turgut, O Bilgir, M S Dal, A Gunes, M H Dogu, S Demircioglu, A Tombak, F Vural, E Gulturk, S Korkmaz, T Ulas, B Eser, F Altuntas","doi":"10.4103/njcp.njcp_499_24","DOIUrl":"https://doi.org/10.4103/njcp.njcp_499_24","url":null,"abstract":"<p><strong>Background: </strong>Extranodal natural killer/T-cell lymphoma, nasal type (ENKL), or nasal NK/T-cell lymphoma is the most common cause of the syndrome known as \"fatal midline granuloma.\"</p><p><strong>Aim: </strong>In this study, we aimed to analyze the treatment outcomes of extranodal natural killer (NK)/T-cell lymphomas.</p><p><strong>Methods: </strong>Data of 39 patients from 15 centers were evaluated retrospectively. The characteristics that determine the risk status of the patients, in which treatments they received, and their responses were observed.</p><p><strong>Results: </strong>Complete response was achieved in 21 patients (53.8%) who received first-line therapy. Median follow-up was 12.5 months (range, 1-60 months) and mortality was 56.4% in patients with highly advanced disease. Median overall survival was 16 (95% CI, 13.07-18.93) months.</p><p><strong>Conclusion: </strong>The prognosis of patients with ENKL has been improved with the use of anthracycline-free treatments, but mortality rates remain high in advanced patients.</p>","PeriodicalId":19431,"journal":{"name":"Nigerian Journal of Clinical Practice","volume":"28 5","pages":"602-607"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Predictors of Gestational Diabetes Mellitus in Enugu, Nigeria Using the New International Federation of Gynecology and Obstetrics (FIGO) Diagnostic Criteria.","authors":"G U Odoh, C I Onwuka, E O Ugwu, E I Iloghalu, J E Nnagbo, C I Onwuka, V C Duru, T D Ifezuoke, P C Udealor","doi":"10.4103/njcp.njcp_501_24","DOIUrl":"https://doi.org/10.4103/njcp.njcp_501_24","url":null,"abstract":"<p><strong>Background: </strong>Gestational diabetes mellitus (GDM) is a common medical condition arising from impaired glucose tolerance and complicating pregnancies worldwide. An estimation of its current prevalence using the International Federation of Gynecology and Obstetrics (FIGO) new diagnostic criteria is important in its management.</p><p><strong>Aim: </strong>To determine the prevalence and predictors of GDM among pregnant women attending antenatal care in the two tertiary teaching hospitals in Enugu, Nigeria.</p><p><strong>Methods: </strong>This was a cross-sectional study of 254 pregnant women who attended the antenatal clinics of the University of Nigeria Teaching Hospital (UNTH) and Enugu State University Teaching Hospital (ESUTH), both in Enugu, Nigeria. The eligible women were recruited between 24 and 28 weeks gestational age during which their fasting blood glucose levels were tested and GDM diagnosed using the new FIGO diagnostic criteria, which is fasting plasma glucose of 5.1-6.9 mmoL/L. All data were analyzed using Statistical Package for Social Sciences (SPSS) version 22 (Statistical package for the social sciences (SPSS) software, version 22.0, IBM SPSS, Chicago, Illinois) at 95% confidence level. A P value of < 0.05 was considered statistically significant.</p><p><strong>Results: </strong>The prevalence of GDM was 5.5% (n = 14/254) using the new diagnostic criteria. About 42.9% (6/14) of those who had GDM from the new criteria had no risk factor. Obesity (odds ratio [OR] = 2.14, confidence interval [CI]: 1.07, 4.30, P = 0.04) and family history of diabetes mellitus (OR = 2.50, 95% CI: 1.24, 5.01, P = 0.013) were the predictors of GDM.</p><p><strong>Conclusion: </strong>The prevalence of GDM is high with the new diagnostic criteria. Obesity and family history of diabetes mellitus were the predictors of GDM in Enugu, Nigeria.</p>","PeriodicalId":19431,"journal":{"name":"Nigerian Journal of Clinical Practice","volume":"28 5","pages":"648-653"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Case-Based Learning Combined with PDCA in the Training of Grassroot Surgeons for the Updates in the CSCO Guidelines for the Diagnosis and Treatment of Breast (2023).","authors":"J Li, G Hu, G Zhao","doi":"10.4103/njcp.njcp_161_24","DOIUrl":"https://doi.org/10.4103/njcp.njcp_161_24","url":null,"abstract":"<p><strong>Background: </strong>In county-level hospitals in China, there is a need to enhance the understanding and implementation of the updates in the Guidelines for the Diagnosis and Treatment of Breast Cancer.</p><p><strong>Aims: </strong>The aim of this study was to evaluate the effectiveness of case-based learning (CBL) integrated with the PDCA (Plan-Do-Check-Act) cycle in improving the knowledge and skills of surgeons related to the most recent Chinese Society of Clinical Oncology (CSCO) Guidelines for the Diagnosis and Treatment of Breast Cancer. Eighty surgeons from county-level hospitals were recruited and randomly assigned to two groups for a comparative study: one experiencing CBL alone and the other receiving CBL combined with the PDCA cycle.</p><p><strong>Methods: </strong>Participants in both groups underwent a 5-day breast cancer therapeutic strategy course. The effectiveness of these methodologies was assessed using pretraining and post-training tests, examinations, and a satisfaction questionnaire. Statistical analysis was conducted to compare the knowledge gains between the two groups using pretraining and post-training assessment scores, with the significance level set at P < 0.05.</p><p><strong>Results: </strong>Both instructional methods resulted in knowledge improvement, but the group that received CBL with PDCA demonstrated significantly higher scores on post-training tests, particularly regarding updates in guidelines (80% vs 76%, P = 0.002) and accuracy in case-based therapeutic plans (92% vs 83%, P < 0.001).</p><p><strong>Conclusion: </strong>The study concludes that the integration of the PDCA cycle with CBL significantly enhances the surgeons' acquisition and application of updated therapeutic knowledge and skills for breast cancer.</p>","PeriodicalId":19431,"journal":{"name":"Nigerian Journal of Clinical Practice","volume":"28 5","pages":"666-671"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Importance of Apparent Diffusion Coefficient in Differentiation of Cerebral Tumors.","authors":"S Y Sağlam, F Kökcü, M E Çeker","doi":"10.4103/njcp.njcp_853_24","DOIUrl":"https://doi.org/10.4103/njcp.njcp_853_24","url":null,"abstract":"<p><strong>Background: </strong>Diffusion-weighted magnetic resonance imaging (MRI) is an advanced functional imaging method based on the molecular motion of water. The diffusion of the water molecules in the tissue is dependent on a number of factors. One factor that modulates the diffusion of water molecules is the cell density in the tissue and the nuclear/cytoplasmic volume ratio, which is often increased in high-grade tumors.</p><p><strong>Aim: </strong>In line with this information, the present study aimed to investigate the role of apparent diffusion coefficient (ADC) values in the differential diagnosis of brain tumors and to demonstrate their contribution to diagnosis.</p><p><strong>Materials and methods: </strong>We measured ADC values in three different regions of the lesion in 317 patients with central nervous system tumors on diffusion-weighted imaging (DWI) and compared the mean calculated ADC values.</p><p><strong>Results: </strong>In our study, ADC values of low-grade glial tumors were significantly higher than all other groups. In the comparison between metastatic patients, the ADC values of the patients with lung metastasis were considerably higher than the ADC values of the patients with metastasis other than breast and lung metastases. In addition, in comparing lung subtypes, we found that the ADC values of patients with histopathological diagnosis of small cell lung cancer (SCLC) were significantly lower than other subtypes. There was no significant difference between high-grade glial tumors and metastases. The number of patients in some subgroups in the metastasis group was insufficient. Therefore, we could not perform statistical analysis, but the mean ADC values of patients with renal cell carcinoma (RCC) metastasis were approximately 0.521 × 10-3 mm2/s and were lower than the ADC values of other metastatic tumors.</p><p><strong>Conclusion: </strong>In the differential diagnosis of central nervous system (CNS) tumors, DWI makes important contributions to conventional MRI examinations. If supported by studies with larger and homogeneous groups, more precise and reliable results can be obtained with the help of other imaging findings.</p>","PeriodicalId":19431,"journal":{"name":"Nigerian Journal of Clinical Practice","volume":"28 5","pages":"608-614"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adopting Virtual Reality in Medical Education: Insights from Clinical Students and Lecturers in a Nigerian University.","authors":"O D Otuyemi, O A Ijarotimi, A O Komolafe, S B Aregbesola, O M Adetutu, O B Akinwale, B A Kolawole, O A Okunola, A O Oluwatope, O Abiona, A T Ayinde, L Idowu, O M Agunbiade, A A Adediwura","doi":"10.4103/njcp.njcp_739_24","DOIUrl":"https://doi.org/10.4103/njcp.njcp_739_24","url":null,"abstract":"<p><strong>Background: </strong>The application of virtual reality (VR) in medical education has steadily increased over the years in advanced countries, but its uptake has been low in low- and middle-income countries.</p><p><strong>Aim: </strong>This study explored the feasibility, acceptability, and appropriateness of VR in clinical training/assessment among Nigerian students of Dentistry, Medicine/Surgery, Nursing, and their clinical lecturers.</p><p><strong>Materials and methods: </strong>A cross-sectional study was carried out among 237 clinical students and 71 clinical lecturers enrolled in three Health Sciences Programs at a Nigerian university. Their perceptions were assessed using a structured online questionnaire mailed to students and lecturers' platforms.</p><p><strong>Results: </strong>The age of respondents ranged from 20 to 68 years and were predominantly female gender (56.8%). The majority (91.3%) of respondents judged the model as acceptable, 90.0% acceded to the appropriateness of VR, while 89.3% agreed to its feasibility in medical education. The academic program was significantly associated with acceptability and feasibility of VR for teaching and clinical examination, with dentistry having the highest proportion of ratings across the three domains of outcomes (P < 0.05). Age was significantly associated with the feasibility of VR, with more appeal from younger trainees and trainers (P < 0.05). The medicine/surgery students were less enthusiastic about the appropriateness of VR for teaching and clinical examinations.</p><p><strong>Conclusion: </strong>The use of VR for training and assessment in undergraduate medical education was rated high in terms of its acceptability, appropriateness, and feasibility (>80%). This innovation was more appealing to younger trainees and trainers.</p>","PeriodicalId":19431,"journal":{"name":"Nigerian Journal of Clinical Practice","volume":"28 5","pages":"582-589"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does Breastfeeding Education Influence the Breastfeeding Attitudes of Mothers with Children Suffering from Diarrhea?","authors":"B Gunes, Hy Sevinç Akın, B Akın","doi":"10.4103/njcp.njcp_891_24","DOIUrl":"https://doi.org/10.4103/njcp.njcp_891_24","url":null,"abstract":"<p><strong>Background: </strong>Diarrhea is more frequent stooling than is normal for an individual. It is one of the leading causes of death among children under the age of five.</p><p><strong>Aim: </strong>This study aims to evaluate the impact of breastfeeding education on the attitudes of mothers toward breastfeeding, particularly in the context of caring for children with diarrhea.</p><p><strong>Patients and methods: </strong>The study employed a pre-test/post-test intervention design with both experimental and control groups. Data were collected from mothers of infants aged 0-2 years who were undergoing treatment for diarrhea, by using a Demographic Information Form and the Iowa Infant Feeding Attitude Scale. A total of 90 mothers participated, with 45 assigned to the education group and 45 to the control group.</p><p><strong>Results: </strong>The study revealed that 7.8% of the infants had never been breastfed, while 52.2% were currently receiving breast milk. Furthermore, 75.6% of the infants had experienced diarrhea within the past month, and 53.3% had a prior history of diarrhea. Notably, 3.3% of the mothers discontinued breastfeeding during their child's diarrheal episode. A statistically significant difference was observed between the pre-test and post-test scores of mothers in the education group, indicating a marked improvement in breastfeeding attitudes following the educational intervention (P < 0.001).</p><p><strong>Conclusion: </strong>Breastfeeding education significantly improves mothers' attitudes, particularly in the context of diarrhea. Educating mothers on the role of breastfeeding in preventing life-threatening conditions such as diarrhea is crucial for child health. Therefore, targeted breastfeeding education programs should be prioritized in pediatric health promotion.</p>","PeriodicalId":19431,"journal":{"name":"Nigerian Journal of Clinical Practice","volume":"28 5","pages":"658-665"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the Relationship between Patient Satisfaction and Self-Esteem in Primary Rhinoplasty.","authors":"M A Say, S Kul, S İpek Şenyiğit","doi":"10.4103/njcp.njcp_835_24","DOIUrl":"https://doi.org/10.4103/njcp.njcp_835_24","url":null,"abstract":"<p><strong>Background: </strong>High self-esteem is believed to be critical for achieving success in work and education; therefore, it is important to promote self-esteem and prevent low self-esteem. Aesthetic procedures such as rhinoplasty can maintain and improve self-esteem by maintaining a positive self-image.</p><p><strong>Aim: </strong>To determine whether primary rhinoplasty can improve self-esteem in patients and investigate the relationship between self-esteem improvement and patient satisfaction after surgery.</p><p><strong>Methods: </strong>Patients who underwent primary rhinoplasty surgery were included in this study. The Rhinoplasty Outcome Evaluation (ROE) questionnaire was administered preoperatively and one year after the operation to assess participant satisfaction. The Rosenberg Self-Esteem Scale was administered preoperatively and 1 year after the operation to assess self-esteem.</p><p><strong>Results: </strong>In total, 88 patients were included in this study. A significant difference was found between their preoperative and postoperative ROE scores (P < .05). Similarly, a significant difference was observed between their preoperative and postoperative Rosenberg scores (P < .05). The patients were divided into low satisfaction and high satisfaction groups: those with ROE percentage scores of >85% and those with ROE percentage scores of <85%. A statistically significant difference was found between the low and high satisfaction groups in terms of preoperative and postoperative Rosenberg scores (P < .05). The Rosenberg scores of the low satisfaction group were significantly lower.</p><p><strong>Conclusions: </strong>Rhinoplasty can improve self-esteem in patients, suggesting that it has a positive effect on the mental health of the community along with social benefits and evaluation of preoperative patients' self-esteem guides surgeons in predicting postoperative rhinoplasty results.</p>","PeriodicalId":19431,"journal":{"name":"Nigerian Journal of Clinical Practice","volume":"28 5","pages":"654-657"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic Inflammatory Response Index in Cervical Pathologies (Human Papillomavirus and Cervical Neoplasia) and its Prognostic Value in Disease Prediction.","authors":"N Cim, E Ayguler, N Gunal, B Cim, H Argun Atalmis, A Cetin","doi":"10.4103/njcp.njcp_581_24","DOIUrl":"https://doi.org/10.4103/njcp.njcp_581_24","url":null,"abstract":"<p><strong>Background: </strong>Cervical pathologies, from chronic cervicitis to cervical cancer, are a global public health issue. Inflammation is crucial to these disorders' development. The systemic inflammatory response may predict cancer and chronic inflammatory disease outcomes.</p><p><strong>Aim: </strong>This study aimed to determine the importance of systemic inflammatory response indicators in human papillomavirus (HPV) infection and cervical pathologies.</p><p><strong>Methods: </strong>In this retrospective analysis, pap smear, HPV, cervical biopsy, complete blood count (CBC) parameters, and systemic inflammatory response index (SIRI) of women who underwent gynecological examination were evaluated.</p><p><strong>Results: </strong>The study included 452 women. Mean platelet volume (MPV) was comparable in HPV other high-risk positive and negative women but lower in HPV Type-16/18 positive women (P < 0.001). Neutrophil/lymphocyte ratio, lymphocyte/monocyte ratio, eosinophil/lymphocyte ratio (ELR), platelet/lymphocyte ratio (PLR), systemic inflammatory index [SII (platelet × neutrophil/lymphocyte)], and SIRI (neutrophil × monocyte/lymphocyte) were also similar (P > 0.05). Low-grade intraepithelial lesion (LSIL) women have lower ages and pregnancies at pap smear (P < 0.05). The high-grade intraepithelial lesion (HSIL) group showed greater platelet (PLT) counts and decreased MPV than the other groups (P < 0.05). The LSIL group had considerably reduced eosinophil counts (P < 0.05). ELR was lower in the LSIL group (P = 0.004). PLR was the highest for HSIL and lowest for LSIL (P = 0.002). The SII was highest in the HSIL group and lowest in the LSIL group (P = 0.008). PLT and MPV were lower in the cervical biopsy-classified women than in the other cervical pathology and control groups (P = 0.03 and 0.001, respectively).</p><p><strong>Conclusion: </strong>We found a link between the mean PLT volume and HPV-related cervical disease.</p>","PeriodicalId":19431,"journal":{"name":"Nigerian Journal of Clinical Practice","volume":"28 5","pages":"615-623"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antithrombotic Effect of Ginkgo Biloba Extract: A Study Based on Network Pharmacological Analysis and In vivo Experiments.","authors":"H Yang, H Yang, W Ma, K Yang, J Liao, Y Zhao","doi":"10.4103/njcp.njcp_770_24","DOIUrl":"https://doi.org/10.4103/njcp.njcp_770_24","url":null,"abstract":"<p><strong>Background and aims: </strong>Thrombosis is a major contributor to cardiovascular and cerebrovascular diseases. Despite the availability of anticoagulants and thrombolytic agents, their clinical use is often limited by adverse effects. Ginkgo biloba extract (GbE), a traditional herbal medicine, has shown promise in alleviating thrombosis, but its underlying mechanisms remain insufficiently understood. This study aimed to explore the antithrombotic effects and molecular mechanisms of GbE through network pharmacology and in vivo experiments.</p><p><strong>Methods: </strong>Online databases were utilized for identifying the GbE's active components and target genes, accompanied by thrombosis-related targets. Functional enrichment analyses, including Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analysis, were performed. A drug-active component-target gene-signaling pathway network and a protein-protein interaction (PPI) network were constructed to determine core target genes and pathways. In vivo, a deep vein thrombosis (DVT) model was established by ligating the inferior vena cava in male Sprague-Dawley rats. Hematoxylin and eosin staining was adopted for evaluating the vascular endothelial structure. The levels of cyclic guanosine monophosphate (cGMP), prostaglandin I2 (PGI2), nitric oxide (NO), and fibrinogen (FIB) were measured, accompanied by the activated partial thromboplastin time (APTT), thrombin time (TT), and prothrombin time (PT). Western blot analysis was performed to examine the PI3K/AKT pathway-related protein expression.</p><p><strong>Results: </strong>GbE comprised 27 active components with 4727 target genes and 2462 thrombosis-related targets, with 974 shared targets, including AKT1, ALB, GAPDH, TNF, and IL6, enriched in PI3K-AKT and AGE-RAGE pathways. Molecular docking indicated strong binding of GbE's main components to core targets. In vivo, GbE significantly relieved vascular lesions of DVT rats; reduced thrombotic wet weight; increased NO, cGMP, and PGI2 levels; decreased FIB; and prolonged APTT, PT, and TT (P < 0.05). Additionally, Western blot highlighted the suppressed p-PI3K/PI3K and p-AKT/AKT ratios in DVT rats.</p><p><strong>Conclusions: </strong>GbE alleviates thrombosis by increasing antithrombotic factors and reducing coagulation, potentially via downregulating the PI3K/AKT signaling. Future studies should focus on long-term clinical trials and broader animal models to further validate GbE's therapeutic potential and explore other molecular mechanisms.</p>","PeriodicalId":19431,"journal":{"name":"Nigerian Journal of Clinical Practice","volume":"28 5","pages":"624-632"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}