Nigerian Journal of Clinical Practice最新文献

{"title":"Congenital Anomalies of the Kidney and Urinary Tract in Southeast Nigeria: Findings from Computed Tomography Scan.","authors":"S K Anyimba, E K Mgbe, O M Mbadiwe, A C Onuh, O C Amu, L T Okolie, A E Ime","doi":"10.4103/njcp.njcp_102_25","DOIUrl":"https://doi.org/10.4103/njcp.njcp_102_25","url":null,"abstract":"<p><strong>Background: </strong>There is a paucity of information and data on congenital anomalies of the kidney and urinary tract (CAKUT) in the African setting.</p><p><strong>Aim: </strong>The aim of this study was to determine the prevalence, pattern and distribution of CAKUT as observed from computed tomography (CT) scans in a black African population.</p><p><strong>Methods: </strong>This was a retrospective study carried out in Enugu, Southeast Nigeria. The study population was drawn from subjects who had an abdominopelvic CT scan or CT urography for either urological or non-urological conditions. Data was pulled from three large-volume referral centers for CT scans in the city center, and study period extended from January 2015 to December 2024. Analysis was performed using Statistical Package for Social Sciences (IBM Corp., Armonk, NY, USA) for Windows, version 27.0. Data were described using frequencies and proportions in tables and charts.</p><p><strong>Results: </strong>The records of 3507 subjects were retrieved for this study. A total number of 122 subjects had congenital anomalies of the kidneys or the urinary tract, which gave a prevalence of 3.5% (95% confidence interval: 2.9-4.1%). The mean age of subjects was 39 ± 19.8 years and the majority of them were males (57.4%). The most prevalent anomaly was pelviureteric junction (PUJ) obstruction (1.28%), followed by duplex collecting system.</p><p><strong>Conclusion: </strong>The prevalence of CAKUT from this study was 3.5%. Pelvic ureteric junction obstruction was the most prevalent congenital anomaly of the urinary tract in our setting.</p>","PeriodicalId":19431,"journal":{"name":"Nigerian Journal of Clinical Practice","volume":"28 8","pages":"931-936"},"PeriodicalIF":0.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the Results of Microsurgical Techniques in Lumbar Disc Herniation: A Retrospective Analysis.","authors":"M O Yüksel, A Besnek, N U Unlü, B Erdoğan","doi":"10.4103/njcp.njcp_103_25","DOIUrl":"https://doi.org/10.4103/njcp.njcp_103_25","url":null,"abstract":"<p><strong>Background: </strong>When surgical intervention is required for lumbar disc herniation, microdiscectomy is frequently employed. Although sequestrectomy has been compared in several aspects, there is limited evidence regarding clinical outcomes. In this study, we aimed to analyze the clinical effectiveness of both techniques by focusing on their postoperative results.</p><p><strong>Aims: </strong>This study aims to compare the clinical outcomes of sequestrectomy and microdiscectomy with sequestrectomy in patients with single-level lumbar disc herniation, focusing on postoperative pain relief and functional recovery.</p><p><strong>Methods: </strong>A total of 110 patients of any age or gender who had been surgically treated in our clinic for clinically and radiologically confirmed single-level lumbar disc herniation were included. Patients were recorded as having undergone sequestrectomy or discectomy with sequestrectomy, with no significant missing data in preoperative imaging and epicrisis documents. Patients with stabilization procedures, previous surgical history at the same level, or those who had undergone far lateral discectomy were excluded. Postoperative clinical outcomes were analyzed according to the surgical methods employed.</p><p><strong>Results: </strong>In patients who underwent sequestrectomy and those who received microsurgical combined sequestrectomy, the postoperative leg pain visual analog scale scores were determined to be 2.51 ± 0.73 (median: 2.00) and 2.38 ± 0.63 (median: 2.00), respectively. No significant difference was observed between the groups (t: 1.01; P: 0.32). Both groups exhibited a statistically significant decrease in leg pain over time. The Cohen's d value in the sequestrectomy group was higher than that in the microsurgical group, indicating a greater effect size for pain reduction over time in the sequestrectomy cohort.</p><p><strong>Conclusions: </strong>Our study suggests that patients undergoing sequestrectomy achieve better pain control over time, particularly in terms of radiculopathy. We believe that sequestrectomy may be more appropriate for younger patients to preserve disc height and tissue.</p>","PeriodicalId":19431,"journal":{"name":"Nigerian Journal of Clinical Practice","volume":"28 8","pages":"988-993"},"PeriodicalIF":0.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: Clinical Efficacy of Tobramycin Dexamethasone+Pranoprofen Eye Drops on Endophthalmitis in Cataract Patients Complicated with Diabetes Mellitus after Intraocular Lens Implantation.","authors":"","doi":"10.4103/njcp.njcp_532_25","DOIUrl":"https://doi.org/10.4103/njcp.njcp_532_25","url":null,"abstract":"","PeriodicalId":19431,"journal":{"name":"Nigerian Journal of Clinical Practice","volume":"28 8","pages":"994"},"PeriodicalIF":0.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the Effect of Different Surface Treatments Applied to Titanium Dental Implant Abutments on the Retention of CAD/CAM Zirconium-Supported Ceramic Crowns.","authors":"F Oktay, N Yanikoğlu, F Bayındır","doi":"10.4103/njcp.njcp_41_24","DOIUrl":"https://doi.org/10.4103/njcp.njcp_41_24","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to investigate the effect of abutment surface treatments (sandblasting and acid or alkali treatments) on the bonding of titanium dental implant abutments and zirconium-supported ceramic crowns with resin-reinforced glass ionomer cement.</p><p><strong>Aim: </strong>The aim of this research was to determine the optimal surface conditioning method for titanium abutments by comparing the tensile bond strength of resin-reinforced glass ionomer cement after sandblasting, acid etching, and alkali treatment.</p><p><strong>Methods: </strong>Seventy-six dental implant abutments (AnyOne; MegaGen Co. Ltd., Kyungsan, South Korea) were used in this study. Zirconia-based ceramic crowns for mandibular first molars were fabricated on the titanium abutments. The abutment samples were divided into four groups: a) sandblasting, b) sandblasting followed by acid treatment, c) sandblasting followed by alkaline treatment, and d) a control group. The samples were subjected to surface treatment and imaged using an electron microscope (SEM). The samples of each group were cemented onto ceramic crowns using a glass ionomer reinforced with the radiopaque resin GC FujiCEM Evolve. The specimens were placed in copper anodes with acrylic resin, leaving the neck of the implant analogues and crowns on the exposed abutments. All samples were subjected to a thermal cycling test (5,000 cycles) prior to tensile testing, followed by a tensile test on a universal testing machine, and the bond strength values were recorded. The data obtained were statistically analysed using a one-way ANOVA and the Tukey test.</p><p><strong>Results: </strong>This study showed that surface treatment significantly affects the tensile bond strength between titanium abutments and zirconia-supported crowns. The highest bond strength was observed in the group treated with 48% H2SO4 after Al2O3 sandblasting, while the lowest was in the untreated control group. Although sandblasting alone was effective, subsequent alkali treatment significantly reduced bond strength. SEM analysis confirmed that acid-treated surfaces had the most favorable roughness for micromechanical retention. Proper surface conditioning is essential for the long-term success of implant-supported restorations.</p><p><strong>Conclusion: </strong>This study showed that surface treatments significantly influence the bond strength between titanium abutments and zirconia crowns. The highest tensile strength was achieved with Al2O3 sandblasting followed by 48% H2SO4 acid etching. In contrast, alkali treatment reduced bonding effectiveness. Acid etching after sandblasting is recommended for improved long-term retention of implant-supported restorations.</p>","PeriodicalId":19431,"journal":{"name":"Nigerian Journal of Clinical Practice","volume":"28 8","pages":"880-888"},"PeriodicalIF":0.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of a Dietary Care Combined with Nutritional Management Model in Elderly Patients with Chronic Heart Failure.","authors":"W Yu, C Jiang, L Zhao","doi":"10.4103/njcp.njcp_929_24","DOIUrl":"https://doi.org/10.4103/njcp.njcp_929_24","url":null,"abstract":"<p><strong>Background: </strong>Chronic heart failure (CHF) is a life-threatening syndrome. Recently, a dietary care combined with nutritional management (DCNM) has become an important component in the management of various diseases.</p><p><strong>Aim: </strong>To investigate the impact of a DCNM model on the recovery and nutritional status of elderly patients with CHF.</p><p><strong>Methods: </strong>This prospective observational cohort study included 85 elderly patients with CHF. In the DCNM group, nursing staff developed personalized dietary care combined with nutritional management interventions. All patients underwent a six-month nursing intervention, during which the patients' nutritional indicators, including serum albumin, hemoglobin, transferrin, and prealbumin levels, were recorded. Additionally, clinical indicators relevant to the patients' condition were assessed after the 6-month intervention period.</p><p><strong>Results: </strong>The levels of albumin, hemoglobin, transferrin, and prealbumin in the DCNM group were significantly higher than those in the conventional group. Additionally, patients in the DCNM group had significantly lower levels of serum NT-proBNP, significantly longer 6-minute walk test (6WMT) distances, higher LVEF and SF-36 scores, and higher proportion of improved heart function by 1 grade. Moreover, we found that DCNM care may improve the prognosis of patients. Finally, the results of logistic regression analysis showed that albumin, prealbumin, and DCNM care were factors associated with significant treatment efficacy in CHF patients.</p><p><strong>Conclusion: </strong>In conclusion, our study demonstrates the beneficial effects of a dietary care combined with nutritional management model in improving the nutritional status, cardiac function, and therapeutic outcomes of elderly patients with chronic heart failure.</p>","PeriodicalId":19431,"journal":{"name":"Nigerian Journal of Clinical Practice","volume":"28 8","pages":"916-922"},"PeriodicalIF":0.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Mode of Delivery on Incidence of Urinary and Anal Incontinence after Childbirth: A Prospective Cohort Study of Nigerian Women.","authors":"H C Nnaji, E O Ugwu, S N Obi, P U Agu, C C Dim, E C Ezugwu, G U Eleje, A C Eke, E E Asimadu, K C Obioha, M I Eze, K E Ekwazi, O S Okoro, C O Adiri, O D Onodugo","doi":"10.4103/njcp.njcp_150_25","DOIUrl":"https://doi.org/10.4103/njcp.njcp_150_25","url":null,"abstract":"<p><strong>Background: </strong>Urinary incontinence (UI) and anal incontinence (AI) are common postpartum complications that significantly affect quality of life. However, evidence on how mode of delivery influences their incidence remains limited.</p><p><strong>Aim: </strong>To assess the effect of mode of delivery on the incidence of UI and AI among postpartum women.</p><p><strong>Methods: </strong>This prospective cohort study involved postpartum mothers at a Nigerian tertiary hospital. Women who had cesarean section (CS) formed the exposed group, while those with vaginal delivery (VD) served as controls. The CS group was subdivided into elective CS (A1CS), emergency CS in the first stage of labor (A2CS), and emergency CS in the second stage (A3CS). Participants were followed up postpartum and assessed for UI and AI using validated questionnaires.</p><p><strong>Results: </strong>Vaginal delivery was associated with a significantly higher risk of both UI (RR = 2.8; 95% CI: 1.2-6.5; P = 0.02) and AI (RR = 2.1; 95% CI: 1.1-4.3; P = 0.03) compared to CS overall. Subgroup analysis showed that VD was significantly associated with a higher risk of UI than A1CS (P = 0.03) and A2CS (P = 0.02), but lower than A3CS (P < 0.01). A similar trend was observed for AI, with VD posing greater risk than A1CS (P = 0.02) and A2CS (P = 0.01), but lower risk than A3CS (P < 0.001). Grand multiparity (P = 0.04) and macrosomia (P < 0.001) were also significantly associated with UI but not with AI (P = 0.09 and 0.08, respectively).</p><p><strong>Conclusion: </strong>Mode of delivery significantly influences the risk of postpartum UI and AI. Elective and early-stage emergency CS appear to reduce risk, while CS performed in the second stage of labor increases it. These findings support individualized counseling and delivery planning to help mitigate long-term pelvic floor dysfunction in high-risk women.</p>","PeriodicalId":19431,"journal":{"name":"Nigerian Journal of Clinical Practice","volume":"28 8","pages":"978-987"},"PeriodicalIF":0.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence, Risk Factors and Management of Ocular Rhabdomyosarcoma (ORMS) in Africa: A Systematic Review.","authors":"E Ezeanosike, O B Ezeanosike, C N Ezisi, D I Aniemeka, N Ogbu, C R Okanya, K K Joe-Akunne, O C Arinze, S Kaliki","doi":"10.4103/njcp.njcp_128_25","DOIUrl":"10.4103/njcp.njcp_128_25","url":null,"abstract":"<p><p>Rhabdomyosarcoma (RMS) is the most common paediatric orbital malignancy, accounting for about 10% of orbital tumours. Reported survival varies widely, ranging from as low as 10% with unimodal treatment to over 70% with multimodal therapy. Data from Africa remain sparse, with studies showing wide variations in methodology and treatment protocols. This systematic review and meta-analysis aimed to determine the prevalence, risk factors, and treatment modalities for ocular rhabdomyosarcoma in Africa. Following PRISMA guidelines and using a PICO framework, relevant databases were searched with appropriate keywords and medical subject headings. Thirty-nine studies met the inclusion criteria and were analysed using Microsoft Excel 365 and Stata IC software. The findings revealed that prevalence, incidence, and risk factors could not be reliably determined due to heterogeneity and inconsistencies in study designs. Evaluation of treatment outcomes was also not feasible as most studies lacked adherence to standardized guidelines, limiting comparability. Nevertheless, proptosis emerged as the most frequent presenting symptom, appearing earlier in the disease course than in other ocular malignancies. Surgery and chemotherapy were the most commonly employed treatment modalities. Overall, the evidence from Africa is inconclusive, and the variability in study designs coupled with the absence of standardized reporting reduces the generalizability of findings. Strengthening oncology care in Africa requires standardization of research protocols, subspecialty training, and the establishment of multidisciplinary oncology teams at all levels.</p>","PeriodicalId":19431,"journal":{"name":"Nigerian Journal of Clinical Practice","volume":"28 8","pages":"867-879"},"PeriodicalIF":0.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential Cross-Talk Between Arterial Calcifications.","authors":"Ş Koç, V Kaplanoğlu","doi":"10.4103/njcp.njcp_246_25","DOIUrl":"https://doi.org/10.4103/njcp.njcp_246_25","url":null,"abstract":"<p><strong>Background: </strong>Vascular calcification is a hallmark of atherosclerosis and an independent predictor of major cardiovascular events.</p><p><strong>Aim: </strong>This study examines age-related correlations between abdominal aortic and coronary calcifications on CT to explore potential systemic vascular cross-talk.</p><p><strong>Method: </strong>In total, 921 patients (508 males (55%), 413 females (44.7%)) were grouped by age: 40-49, 50-69, and 70-90 years. Non-contrast abdominal CT was used to assess calcifications in the coronary arteries, thoracic aorta, suprarenal (AA (1)), renal (AA (2)), infrarenal aorta (AA (3)), iliac arteries, and femoral arteries. Aortic calcification was classified as none, <25%, 25%-50%, or ≥50%. Categorical variables were compared using the Chi-square test with Bonferroni correction, and inter-rater reliability was assessed via ICC.</p><p><strong>Results: </strong>In the 50-69 age group, when AA (1) showed no calcification, LAD calcification was 17.9%. With <25% AA (1) calcification, LAD and Cx rates were 4% and 22%, respectively. In AA (2) and AA (3), these rates were similar (4%-23% and 4%-19%, respectively; P < 0.05). When the iliac or femoral arteries were free of calcification, the prevalence of LAD and Cx calcifications was 4%, 1%, and 6% for LAD, and 18%, 17%, and 14% for Cx, respectively. When calcification was present at <25%, these rates increased to 23%, 32%, and 29% for LAD, and 9%, 8%, and 13% for Cx (P < 0.05). No significant association was observed in other age groups. This relationship was not statistically significant in individuals aged 40-49 years and 70-90 years.</p><p><strong>Conclusion: </strong>A significant association between AA calcification and Cx, as well as between post-aortic bifurcation calcifications and LAD calcifications, was found in individuals aged 50-69 years.</p>","PeriodicalId":19431,"journal":{"name":"Nigerian Journal of Clinical Practice","volume":"28 8","pages":"937-945"},"PeriodicalIF":0.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survival Analysis and Death-Related Factor in Stage 4 Ovarian Cancer from the National Cancer Hospital in Indonesia.","authors":"H Tadjoedin, K D Suryana, Wlh Hanafi, M P Kunigara, A F Shiba","doi":"10.4103/njcp.njcp_815_24","DOIUrl":"https://doi.org/10.4103/njcp.njcp_815_24","url":null,"abstract":"<p><strong>Background: </strong>The incidence and the mortality rate of ovarian cancer (OC) in Indonesia are higher than in the world, approximately 9.8% and 4.0%. As a cancer referral hospital, understanding the survival patterns and death-related factors is crucial for improving management. However, data on the survival is still lacking.</p><p><strong>Aim: </strong>To determine and analyze survival and death-related factors in stage IV OC patients.</p><p><strong>Materials and methods: </strong>The data for this study were obtained from the cancer registry of Dharmais National Cancer Hospital from 2018 to 2022. This study included patients with suspected stage IV OC, diagnosed through histopathology and radiology. A retrospective cohort follow-up was conducted until June 2024. Bivariate and survival analyses were performed using SPSS version 30.0.</p><p><strong>Results: </strong>This study involved 100 subjects, and the results indicated that the histopathology sub type (P = 0.020), line of chemotherapy (P = 0.005), residual disease status (P = 0.001), and CA-125 levels (P = 0.009) had the significant impact on mortality. However, multivariate analysis revealed no independent mortality-related factors. Notably, the type of treatment emerged as the only variable that significantly influenced survival (P < 0.001).</p><p><strong>Conclusion: </strong>The histopathology sub type, line of chemotherapy, residual disease status, and CA-125 levels influenced the mortality in stage IV OC. Stage IV OC showed a significant association between treatment with overall survival (OS). Treatment with neoadjuvant chemotherapy (NACT) is highly recommended because it shows high survival rate and median OS results.</p>","PeriodicalId":19431,"journal":{"name":"Nigerian Journal of Clinical Practice","volume":"28 8","pages":"904-908"},"PeriodicalIF":0.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neutrophil Gelatinase-Related Lipocalin and Renal Resistive Index in the Diagnosis and Prognosis of Sepsis-Associated Acute Kidney Injury: A Cross-Sectional Study from Türkiye.","authors":"A B Teker, D Duzencı, N Teker, H Senturk, M Bıcakcıoglu, Z Dogan, A B Ozer","doi":"10.4103/njcp.njcp_720_24","DOIUrl":"https://doi.org/10.4103/njcp.njcp_720_24","url":null,"abstract":"<p><strong>Background: </strong>Acute kidney injury (AKI) is common in intensive care unit (ICU) and sepsis-induced AKI (SI-AKI) is a cause of the high mortality and morbidity.</p><p><strong>Aim: </strong>To determine the use of neutrophil gelatinase-related lipocalin (NGAL) and Renal Resistive Index (RRI) in the predicting the development of AKI and mortality in patients with sepsis in the ICU.</p><p><strong>Methods: </strong>Patients with sepsis who were admitted into the ICU were divided into the AKI and non-AKI groups. On the first and fifth days after sepsis diagnosis, blood samples were taken for NGAL levels while RRIs were measured via doppler ultrasound. Simultaneously, fluid responsiveness and perfusion status were evaluated with pleth variability index (PVI) and pulsatility index (PI). Twenty-eight day mortality was recorded.</p><p><strong>Results: </strong>The mean age of 101 patients was 63 years and 69% were male. On the first day, the NGAL (P = 0.002), RRI (P = 0.001) and PVI (P = 0.001) were significantly higher while the PI (P = 0.018) was lower in the AKI group. On the fifth day, the RRI and PVI were significantly higher in the AKI group. (P = 0.001). The RRI and PVI on the first and 5th days were significantly higher, while the PI was lower in non-surviving group (P = 0.001). The parameter that best predicted the development of AKI was RRI (area under curve [AUC] = 0.898, P = 0.001). The RRI, PI and PVI values were significantly associated with mortality (respectively AUC value 0.722, 0.714, 0.700, P = 0.001).</p><p><strong>Conclusions: </strong>The RRI is an important marker for predicting AKI in the early phase of sepsis and mortality in acutely ill patients, while NGAL is a biomarker that can predict AKI.</p>","PeriodicalId":19431,"journal":{"name":"Nigerian Journal of Clinical Practice","volume":"28 8","pages":"889-896"},"PeriodicalIF":0.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}