{"title":"Maximum standardized uptake value in <sup>11</sup>C-methionine positron emission tomography may predict the prognosis of patients with oral squamous cell carcinoma.","authors":"Takeshi Kuroshima, Yoshimasa Kitagawa, Jun Sato, Shiro Watanabe, Takuya Asaka, Takahiro Abe, Hiroyuki Harada, Kenji Hirata, Yuji Kuge","doi":"10.1007/s10266-024-00946-w","DOIUrl":"10.1007/s10266-024-00946-w","url":null,"abstract":"<p><p>The present study aimed to elucidate the correlation between the uptake of <sup>11</sup>C-methionine (MET) by a primary tumor and the survival of patients with oral squamous cell carcinoma (OSCC). This study enrolled 31 patients who underwent radical surgery for OSCC. The patients underwent pretreatment MET-positron emission tomography (PET) scanning. We analyzed correlations between the maximum standardized uptake value (SUV<sub>max</sub>) of MET-PET in a primary tumor and the clinicopathological features. Further, we compared overall survival (OS), disease-specific survival (DSS), and loco-regional recurrence (LRR) rates between the two groups according to SUV<sub>max</sub> of MET-PET. SUV<sub>max</sub> of MET-PET in a primary tumor was higher in patients with advanced T-classification and advanced clinical stage, with significant differences (P = 0.001 and P = 0.016, respectively). The patients with SUV<sub>max</sub> of MET-PET ≥ 4.4 showed significantly lower DSS rates and higher LRR rates than those with SUV<sub>max</sub> of < 4.4 (P = 0.015 and P = 0.016, respectively). SUV<sub>max</sub> of MET-PET and OS rates showed no significant correlation (P = 0.073). The present study revealed that SUV<sub>max</sub> of MET-PET may predict clinical outcomes and prognosis in patients with OSCC who underwent radical surgery.</p>","PeriodicalId":19390,"journal":{"name":"Odontology","volume":" ","pages":"372-378"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140857290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
OdontologyPub Date : 2025-01-01Epub Date: 2024-05-20DOI: 10.1007/s10266-024-00952-y
Ana Cláudia Dalmolin, Kellen Rutes Silva, Iolanda Cristina Justus Dechandt, Karen Cristiane Ribeiro, Leonardo Sant'Ana Gallo, Márcia Thaís Pochapski, Francisco Carlos Serbena, Fábio André Dos Santos
{"title":"Efficiency of cavitary varnishes containing experimental bioglass particles in the occlusion of dentinal tubules.","authors":"Ana Cláudia Dalmolin, Kellen Rutes Silva, Iolanda Cristina Justus Dechandt, Karen Cristiane Ribeiro, Leonardo Sant'Ana Gallo, Márcia Thaís Pochapski, Francisco Carlos Serbena, Fábio André Dos Santos","doi":"10.1007/s10266-024-00952-y","DOIUrl":"10.1007/s10266-024-00952-y","url":null,"abstract":"<p><p>This research aims to evaluate the efficiency of cavitary varnishes containing experimental bioglasses in the occlusion of dentinal tubules. One hundred and sixty-eight cervical buccal dentin samples were obtained from bovine teeth. Samples were randomized into the following groups: I. Distilled Water (DW); II. Cavity Varnish (CV); III. Colgate<sup>®</sup> Sensitive Pro-Relief™ (CS); IV. 45S5 Bioglass (45S5); V. KSr Bioglass strontium potassium (KSr); VI. P Bioglass phosphorus (P); and VII. PSi Bioglass phosphorus silica (PSi). The treatments were applied to the surfaces of the samples, which were then subjected to simulated brushing. The samples were analyzed for a) characterization of bioactive glasses; b) surface roughness; c) descriptive analysis of the dentin surface; d) total versus occluded number of dentinal tubules; e) diameter of the dentinal tubules; f) chemical composition of the dentin surfaces, and g) dentin permeability. All groups treated with biomaterials without the brushing challenge showed an increase in roughness and (total or partial) occlusion of the dentinal tubules. The PSi group had the best values for occlusion, while the KSr group had the highest calcium and phosphorus concentrations. After the brushing challenge the roughness was controlled by the presence of biomaterials; 45S5, KSr, and PSi showed occlusion of the dentin tubules. All bioactive glasses showed reduced tooth permeability compared to distilled water. The PSi group had the smallest tubule diameter and highest phosphorus concentration. KSr and PSi bioglasses are promising materials for dentin occlusion and remineralization and are promising new biomaterials for the treatment of dentin hypersensitivity.</p>","PeriodicalId":19390,"journal":{"name":"Odontology","volume":" ","pages":"143-155"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141071543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
OdontologyPub Date : 2025-01-01Epub Date: 2024-06-29DOI: 10.1007/s10266-024-00971-9
Guilherme Pauletto, Renan Vaz Machry, Tadeu Baumhardt, Natália de Freitas Daudt, Gabriel Kalil Rocha Pereira, Carlos Alexandre Souza Bier
{"title":"Effect of radiotherapy, immediate dentin sealing and irrigation simulating single- or two-visits endodontic treatment on the bond strength to pulp chamber dentin: an in vitro study.","authors":"Guilherme Pauletto, Renan Vaz Machry, Tadeu Baumhardt, Natália de Freitas Daudt, Gabriel Kalil Rocha Pereira, Carlos Alexandre Souza Bier","doi":"10.1007/s10266-024-00971-9","DOIUrl":"10.1007/s10266-024-00971-9","url":null,"abstract":"<p><p>This study aimed to evaluate the influence of radiotherapy and different endodontic treatment protocols on the bond strength to pulp chamber dentin. Eighty mandibular molars were randomly divided into two groups (n = 40): non-irradiated and irradiated (60 Gy). The pulp chambers were sectioned, and each group was subdivided (n = 8), according to the endodontic treatment protocol: no treatment (Control); Single-visit; Two-visits; Immediate dentin sealing (IDS) + single-visit; and IDS + two-visits. Each endodontic treatment visit was simulated through irrigation with 2.5% NaOCl, 17% EDTA and distilled water. IDS was performed by actively applying two coats of a universal adhesive to the lateral walls of the pulp chamber. After, the pulp chambers were restored with resin composite and four sticks were obtained for microtensile test. In addition, the dentin of the pulp chamber roof was assessed for surface roughness, chemical composition, and topography after each treatment protocol. Two-way ANOVA, Tukey's post hoc, Mann-Whitney, Kruskal-Wallis and Dunn's post hoc were performed (α = 5%). The treatment protocol affected bond strength (p < 0.05), while the irradiation did not (p > 0.05). The control group presented the highest values (p < 0.05). The single-visit group demonstrated better performance compared to the other groups (p < 0.05), which did not differ from each other (p > 0.05) The use of IDS changed the surface roughness (p < 0.05), chemical composition (p < 0.05) and topography of the dentin. In conclusion, the treatment protocol influenced dentin adhesion, while irradiation did not.</p>","PeriodicalId":19390,"journal":{"name":"Odontology","volume":" ","pages":"261-273"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141477074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
OdontologyPub Date : 2025-01-01Epub Date: 2024-05-17DOI: 10.1007/s10266-024-00950-0
Ines Willershausen, Markus Kopp, Michael Scholz, Armin Ströbel, Corinna Lesley Seidel, Friedrich Paulsen, Michael Uder, Lina Gölz, Matthias Stefan May
{"title":"Feasibility of 3 Tesla MRI for the assessment of mid-palatal suture maturation: a retrospective pilot study.","authors":"Ines Willershausen, Markus Kopp, Michael Scholz, Armin Ströbel, Corinna Lesley Seidel, Friedrich Paulsen, Michael Uder, Lina Gölz, Matthias Stefan May","doi":"10.1007/s10266-024-00950-0","DOIUrl":"10.1007/s10266-024-00950-0","url":null,"abstract":"<p><p>The maxilla occupies a key position in dentofacial orthopaedics, since its transversal development can be directly influenced by orthodontic therapy. The maturation stages of the mid-palatal suture, which are obtained from cone-beam computed tomography images (CBCT), present an addition to clinical decision-making in transversal discrepancies of the upper jaw. In an endeavour to reduce ionizing radiation in adolescents and young adults, who are particularly susceptible to long term stochastic irradiation effects, we investigated the feasibility of 3 Tesla (3T) MRI in detecting the maturation stages of the mid-palatal suture. A collective of 30 patients aged 24-93 years with routine neck MRI at 3T, underwent an additional three-dimensional isotropic T1 weighted study sequence of the midface. Image evaluation was performed on axial, multi-planar formatted reconstructions of the dataset aligned to the midline axis of the palate, and curved reconstructions aligned to the concavity of the palate. Inverted images helped to achieve an image impression similar to the well-known CBCT appearance. All datasets were reviewed by three readers and mid-palatal maturation was scored twice according to Angelieri et al. Intra- and inter-rater agreement were evaluated to measure the robustness of the images for clinical evaluation. 3T MRI deemed reliable for the assessment of mid-palatal suture maturation and hence for the appraisal of the hard palate and its adjacent sutures. The data of this pilot study display the feasibility of non-ionizing cross-sectional MRI for the determination of sutural maturation stages. These findings underline the potential of MRI for orthodontic treatment planning, further contributing to the avoidance of unnecessary radiation doses.</p>","PeriodicalId":19390,"journal":{"name":"Odontology","volume":" ","pages":"390-397"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11717790/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140958663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Characterization of stromal calcifications in odontogenic keratocyst: a multicentric study.","authors":"Karishma Madhusudan Desai, Yoichi Tanaka, Punnya V Angadi, Supriya Mohit Kheur, Uday Puranik, Ayaka Tatsumi, Shoichi Sekikawa, Takeshi Nomura","doi":"10.1007/s10266-024-00975-5","DOIUrl":"10.1007/s10266-024-00975-5","url":null,"abstract":"<p><p>Odontogenic keratocysts (OKCs) are locally aggressive cysts that exhibit typical histopathological features and have a propensity for recurrence. Though histological variations are observed in OKCs, hard tissue formation and metaplastic changes are rare, and the underlying pathogenesis is not well understood. This study aimed to characterize stromal calcifications and analyze their association with odontogenic components in non-syndromic and syndrome-associated cases of OKCs. We analyzed 153 cases of OKCs from healthcare institutes in India and Japan. The epithelial and stromal features were evaluated, and the relationship of calcifications with odontogenic rests was determined. Immunohistochemistry for cytokeratin-19 and special stains including Masson Trichrome and Van Gieson, were used for identification of odontogenic rests and calcifications respectively. Stromal calcifications were observed in 29.41% OKCs. The calcification patterns included irregular dystrophic, dentinoid with linear or calcospherite-type mineralization, and psammoma calcifications. Psammoma and dentinoid calcifications were found in the proximity of cytokeratin-19-positive odontogenic rests or satellite cysts, whereas majority cases with dystrophic calcifications did not exhibit co-localization with stromal odontogenic components. Distinct patterns of calcifications were observed in OKCs. Calcifications found in proximity of the odontogenic rests were possibly indicative of an inductive or host-mediated response.</p>","PeriodicalId":19390,"journal":{"name":"Odontology","volume":" ","pages":"438-447"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141477073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
OdontologyPub Date : 2025-01-01Epub Date: 2024-07-25DOI: 10.1007/s10266-024-00982-6
Pedro Henrique Chaves de Oliveira, Michael Júnio da Silva Rodrigues, Cristiane Cantiga da Silva, Carolina de Barros Moraes Cardoso, Flávio Duarte Faria, Leopoldo Cosme-Silva, Edilson Ervolino, João Eduardo Gomes-Filho, Gustavo Sivieri-Araújo, Luciano Tavares Angelo Cintra
{"title":"Influence of melatonin supplementation on tissue response of endodontic sealers in Wistar rats.","authors":"Pedro Henrique Chaves de Oliveira, Michael Júnio da Silva Rodrigues, Cristiane Cantiga da Silva, Carolina de Barros Moraes Cardoso, Flávio Duarte Faria, Leopoldo Cosme-Silva, Edilson Ervolino, João Eduardo Gomes-Filho, Gustavo Sivieri-Araújo, Luciano Tavares Angelo Cintra","doi":"10.1007/s10266-024-00982-6","DOIUrl":"10.1007/s10266-024-00982-6","url":null,"abstract":"<p><strong>Objective: </strong>This study evaluated the influence of melatonin supplementation on tissue's response of endodontic sealers in Wistar rats.</p><p><strong>Methodology: </strong>Forty-eight rats received subcutaneous implants of four polyethylene tubes: one empty (control) and three filled with endodontic sealers (AH Plus, Endofill and Sealapex). Half of the animals were supplemented with melatonin (ME) and the remaining treated with water (WA) for 15 days before the implantation until euthanasia, forming the groups: control-WA, AH Plus-WA, Endofill-WA, Sealapex-WA, Control-ME, AH Plus-ME, Endofill-ME and Sealapex-ME. After 5, 15 and 30 days, (n = 8) tubes were removed and evaluated in H&E., immunohistochemistry, PSR, VK and POL. The results were statistically analyzed (p < 0.05).</p><p><strong>Results: </strong>In animals treated with water, Endofill-WA evoked more intense inflammatory infiltrate compared to AH Plus-WA and Control-WA in a 30-day period (p < 0.05). In animals supplemented with melatonin, there was any difference among endodontic sealers' response in any period of analysis (p > 0.05). Comparing the individual response of each sealer, over a 30-day period, Endofill-ME and Sealapex-ME showed less inflammatory infiltrate compared to Endofill-WA and Sealapex-WA, respectively (p < 0.05). Immunostaining for IL-6 and TNF-α was less intense for all groups in animals supplemented with melatonin, in most periods, except for the Endofill sealer (p < 0.05). Furthermore, Endofill-ME at 5 days and AH-Plus-ME at 30 days showed a higher percentage of mature collagen fibers compared to the Endofill-WA and AH Plus-WA, respectively (p < 0.05). Positive structures for von Kossa staining and birefringent to polarized light were observed only for Sealapex-WA and Sealapex-ME in all periods.</p><p><strong>Conclusions: </strong>It can be concluded that melatonin influences the tissue response to endodontic sealers, modulating the inflammatory and reparative process.</p>","PeriodicalId":19390,"journal":{"name":"Odontology","volume":" ","pages":"358-371"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141766896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Regular dental check-up status and related factors among Thai residents in Japan.","authors":"Hideki Fukuda, Eiko Kobori, Hiroko Miura, Kaori Mizumoto, Miho Nozue, Sayaka Hazano, Kanami Kamata, Yuko Maeda","doi":"10.1007/s10266-024-00954-w","DOIUrl":"10.1007/s10266-024-00954-w","url":null,"abstract":"<p><p>The objectives of this online study were to determine the status of regular dental check-ups among Thai nationals living in Japan and to identify barriers to regular dental check-ups by comparing them with general health check-ups. We conducted the online survey twice, in 2021 and 2022, among Thai nationals aged 18 years and older living in Japan via social networking services by an organization that supports Thai nationals living in Japan. Respondents between the ages of 30 and 59 were included in this study. Independent factors included gender, age, length of stay in Japan, family economic status, confidence in Japanese and stay for work purposes. Dependent factors were regular dental check-ups and general health check-ups in the past year. Chi-square tests and multiple logistic regression analyses were used for analysis. 56.6% of respondents had regular dental check-ups. The adjusted odds ratio for the proportion of people with regular dental check-ups was significantly higher for those with high economic status, 2.15 (1.06-4.33), compared with those with low economic status. It was also significantly higher 1.88 (1.10-3.21) for those with confidence in the Japanese language compared with those without. The study suggested the need for Japanese language support in addition to financial support for dental health prevention programs for foreigners living in Japan.</p>","PeriodicalId":19390,"journal":{"name":"Odontology","volume":" ","pages":"398-403"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141157248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
OdontologyPub Date : 2025-01-01Epub Date: 2024-06-20DOI: 10.1007/s10266-024-00962-w
Ruya Lv, Yao Yao, Jingjing Dong, Qian Chen
{"title":"COL1A1, mediated by m6A methylation of METTL3, facilitates oral squamous cell carcinoma cell growth and metastasis.","authors":"Ruya Lv, Yao Yao, Jingjing Dong, Qian Chen","doi":"10.1007/s10266-024-00962-w","DOIUrl":"10.1007/s10266-024-00962-w","url":null,"abstract":"<p><p>Collagen type I alpha1 (COL1A1) has been found to be abnormal expressed in oral squamous cell carcinoma (OSCC) tissues, but its role and mechanism in OSCC need to be further elucidated. The expression levels of COL1A1 and methyltransferase-like 3 (METTL3) were measured by quantitative real-time PCR and western blot. Cell growth and metastasis were determined by CCK8, colony formation, EdU, flow cytometry and transwell assays. MeRIP, Co-IP and dual-luciferase reporter assays were performed to explore the interplay of COL1A1 and METTL3. COL1A1 mRNA stability was confirmed by Actinomycin D assay. Mice xenograft models were constructed to perform in vivo experiments. COL1A1 and METTL3 were upregulated in OSCC. COL1A1 knockdown suppressed OSCC cell growth and metastasis, while its overexpression had an opposite effect. The stability of COL1A1 mRNA was regulated by the m6A methylation of METTL3. METTL3 overexpression promoted OSCC cell growth and metastasis, and its knockdown-mediated OSCC cell function inhibition could be abolished by COL1A1 overexpression. Besides, silencing of METTL3 reduced OSCC tumor growth by reducing COL1A1 expression. METTL3-stabilized COL1A1 promoted OSCC progression, providing an exact molecular target for the treatment of OSCC.</p>","PeriodicalId":19390,"journal":{"name":"Odontology","volume":" ","pages":"191-200"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141427363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"METTL3 promotes immature dental pulp stem cells-induced angiogenesis by regulating ETS1 mRNA stability in an m<sup>6</sup>A-HuR-dependent manner.","authors":"Jian Qin, Li Zou, Fachao Lu, Fang Liu, Qian Min, Lilei Zhu","doi":"10.1007/s10266-024-00977-3","DOIUrl":"10.1007/s10266-024-00977-3","url":null,"abstract":"<p><p>Angiogenesis serves as the determinate element of pulp regeneration. Dental pulp stem cell (DPSC) implantation can promote the regeneration of dental pulp tissue. Herein, the role of m<sup>6</sup>A methyltransferase methyltransferase-like 3 (METTL3) in regulating DPSCs-induced angiogenesis during pulp regeneration therapy was investigated. Cell DPSC viability, HUVEC migration, and angiogenesis ability were analyzed by CCK-8 assay, wound healing, Transwell assay, and tube formation assay. The global and EST1 mRNA m6A levels were detected by m<sup>6</sup>A dot blot and Me-RIP. The interactions between E26 transformation-specific proto-oncogene 1(ETS1), human antigen R(HuR), and METTL3 were analyzed by RIP assay. The relationship between METTL3 and the m<sup>6</sup>A site of ETS1 was performed by dual-luciferase reporter assay. ETS1 mRNA stability was examined with actinomycin D. Herein, our results revealed that human immature DPSCs (hIDPSCs) showed stronger ability to induce angiogenesis than human mature DPSCs (hMDPSCs), which might be related to ETS1 upregulation. ETS1 knockdown inhibited DPSCs-induced angiogenesis. Our mechanistic experiments demonstrated that METTL3 increased ETS1 mRNA stability and expression level on DPSCs in an m<sup>6</sup>A-HuR-dependent manner. ETS1 upregulation abolished sh-METTL3's inhibition on DPSCs-induced angiogenesis. METTL3 upregulation promoted DPSCs-induced angiogenesis by enhancing ETS1 mRNA stability in an m<sup>6</sup>A-HuR-dependent manner. This study reveals a new mechanism by which m<sup>6</sup>A methylation regulates angiogenesis in DPSCs, providing new insights for stem cell-based tissue engineering.</p>","PeriodicalId":19390,"journal":{"name":"Odontology","volume":" ","pages":"305-317"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141538267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
OdontologyPub Date : 2025-01-01Epub Date: 2024-07-24DOI: 10.1007/s10266-024-00981-7
Beatriz Danieletto Sahm, Izabela Ferreira, João Marcos Carvalho-Silva, Ana Beatriz Vilela Teixeira, Jean Valdir Uchôa Teixeira, Paulo Noronha Lisboa-Filho, Andréa Cândido Dos Reis
{"title":"Microstructural characterization, mechanical and microbiological properties of acrylic resins added with reduced graphene oxide.","authors":"Beatriz Danieletto Sahm, Izabela Ferreira, João Marcos Carvalho-Silva, Ana Beatriz Vilela Teixeira, Jean Valdir Uchôa Teixeira, Paulo Noronha Lisboa-Filho, Andréa Cândido Dos Reis","doi":"10.1007/s10266-024-00981-7","DOIUrl":"10.1007/s10266-024-00981-7","url":null,"abstract":"<p><p>To evaluate the microstructural characterization, mechanical properties and antimicrobial activity of acrylic resins incorporated with different concentrations of reduced graphene oxide (rGO). Specimens were made of self-cured and heat-cured acrylic resins for the control group and concentrations of 0.5%, 1%, and 3%. The microstructural characterization was evaluated by scanning electron microscopy (SEM) and energy-dispersive X-ray (EDS). For mechanical testing, flexural strength, and Knoop hardness tests were performed. Microbiological evaluations were performed by colony forming units (CFU) analysis, tetrazolium salt reduction (XTT), and SEM images. The modified acrylic resins showed increased mechanical properties at low concentrations (p < 0.05) and with reduced S. mutans (p < 0.05). Reduced graphene oxide interfered with the mechanical performance and microbiological properties of acrylic resins depending on the concentration of rGO, and type of polymerization and microorganism evaluated. The incorporation of graphene compounds into acrylic resins is an alternative to improve the antimicrobial efficacy and performance of the material.</p>","PeriodicalId":19390,"journal":{"name":"Odontology","volume":" ","pages":"340-348"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141752285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}