Odontology最新文献

{"title":"Comparative evaluation of bioactive alkasite-based material in different application modes: a 1-year randomized controlled clinical trial.","authors":"Nada A El-Salamouny, Waleed A Elmahy, Ahmed A Holiel","doi":"10.1007/s10266-025-01095-4","DOIUrl":"10.1007/s10266-025-01095-4","url":null,"abstract":"<p><p>This study evaluated the one-year clinical performance of Cention N, a new alkasite bioactive restorative material, compared to a conventional bulk-fill composite resin in 12 patients aged 18-45 years with class I cavities. The patients were randomly assigned to three groups: Group I (Cention N without adhesive), Group II (Cention N with adhesive), and Group III (Filtek Bulk Fill composite resin). The restorations were monitored at baseline, three, six, and twelve months using the FDI criteria, assessing marginal staining, recurrent caries, and postoperative sensitivity. Statistical analysis was performed using the Monte Carlo correction, chi-square test, and Friedman's test (p ≤ 0.05). The results showed clinically acceptable FDI scores for all restorations at each time interval with no significant differences between the groups (p ≥ 0.05). However, Cention N without adhesive demonstrated slightly inferior outcomes in postoperative sensitivity and marginal staining at the six- and twelve-month intervals. Overall, both materials performed similarly in terms of clinical performance within the first year, though Cention N without adhesive showed marginally lower, but still acceptable, results.Trial registration: ClinicalTrials.gov NCT06273410: 13/10/2022.</p>","PeriodicalId":19390,"journal":{"name":"Odontology","volume":" ","pages":"1689-1700"},"PeriodicalIF":2.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12450802/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144013298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of demineralization, brushing, and remineralization sequences on dentin mineral retention and surface properties.","authors":"Soyeon Kim, Sri Larnani, Ji Eun Son, Napas Lappanakokiat, Van Mai Truong, Bo-Hyoung Jin, Young-Seok Park","doi":"10.1007/s10266-025-01070-z","DOIUrl":"10.1007/s10266-025-01070-z","url":null,"abstract":"<p><p>This study investigates the effects of different treatment sequences involving demineralization, brushing, and remineralization on the calcium and phosphorus (Ca/P) content, surface roughness, and microhardness of dentin specimens. Bovine dentin samples were subjected to the following five treatment conditions: control, demineralization, demineralization followed by remineralization, demineralization followed by brushing then remineralization, and demineralization followed by remineralization then brushing. X-ray fluorescence spectroscopy was then utilized to assess the elementary composition changes, while scanning electron microscopy provided microstructural analyses. Surface roughness and microhardness were also quantified to assess the physical changes in dentin. The control group retained significantly higher Ca/P content compared with all treated groups, indicating that demineralization, regardless of subsequent treatment, leads to a substantial loss of hydroxyapatite. Among the treated groups, those that underwent remineralization immediately after demineralization manifested higher Ca/P retention compared with those that included brushing before remineralization. Additionally, microhardness measurements indicated that post-demineralization brushing negatively affected dentin's microhardness. The sequence of demineralization, brushing, and remineralization treatments significantly affects Ca/P retention in dentin, along with its surface roughness and microhardness. Pre-remineralization brushing diminished mineral recovery, whereas exposure to mineral-rich beverage immediately after demineralization resulted in greater mineral deposition.</p>","PeriodicalId":19390,"journal":{"name":"Odontology","volume":" ","pages":"1456-1466"},"PeriodicalIF":2.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12450817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143503060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of propolis-modified glass ionomer cement on antimicrobial activity and physico-mechanical properties: a systematic review.","authors":"Dina Abozaid, Enas Elwakeel, Maged Ahmed Mohamed, Mohammad A Bahnsawy, Mohamed Eldebawy, Alaaeldin Elraggal, Fatima Alzahraa Abdellah Gwidah, Amr Azab","doi":"10.1007/s10266-025-01209-y","DOIUrl":"https://doi.org/10.1007/s10266-025-01209-y","url":null,"abstract":"<p><p>Glass ionomer cement (GIC) is valued in restorative dentistry for its chemical adhesion, fluoride release, and biocompatibility but has limitations in mechanical strength and long-term antibacterial activity. Propolis, a natural resin rich in flavonoids and phenolic acids, has shown antimicrobial, antioxidant, and anti-inflammatory effects, making it a potential bioactive additive to improve GIC performance. This systematic review evaluates the effects of propolis-modified GIC on antimicrobial activity and physico-mechanical properties, while identifying optimal formulations and concentrations for clinical use. Special emphasis is placed on methodological heterogeneity, chemical characterization gaps, and future research needs. Publications up to the end of 2024 were included from the Cochrane Library, Web of Science, PubMed, and Scopus. The review was registered on PROSPERO (CRD42024627498) and conducted according to PRISMA guidelines using the PICO framework. Propolis-modified GIC generally demonstrated enhanced antibacterial activity against Streptococcus mutans, Lactobacillus, and Candida albicans, particularly at concentrations of 25-50%. Mechanical outcomes varied with concentration, with 25% often balancing antimicrobial efficacy and mechanical stability, while higher concentrations improved hardness but sometimes reduced compressive and bond strength. Considerable heterogeneity was observed in GIC brands, propolis sources, extraction techniques, and incorporation methods, limiting direct comparability. Most studies lacked detailed chemical characterization, making it unclear which flavonoids or phenolic compounds drive the observed effects. Yellow discoloration was the main reported esthetic change, with no studies assessing long-term color stability or translucency. Propolis-modified GIC is a promising bioactive restorative material with potential antimicrobial benefits. However, methodological weaknesses, heterogeneity in preparation, and absence of chemical and long-term esthetic evaluation limit the direct clinical applicability of current evidence. Standardized protocols for material preparation, bioactive component identification, and comprehensive testing of mechanical and esthetic properties are recommended to advance this field.</p>","PeriodicalId":19390,"journal":{"name":"Odontology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145200160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishment of a regenerative endodontic procedures model of mature mouse teeth and evaluation of the wound healing process.","authors":"Xiuting Wang, Shigeki Suzuki, Shin-Ho Tsai, Karin Nagasaki, Rahmad Rifqi Fahreza, Masato Omori, Satoru Yamada","doi":"10.1007/s10266-025-01211-4","DOIUrl":"https://doi.org/10.1007/s10266-025-01211-4","url":null,"abstract":"<p><p>As the pulp regeneration for non-vital teeth is one of the ultimate clinical achievements, regenerative endodontic procedures (REPs) have become the most explored treatment modality. In this technique, periodontal tissue is guided from the apical region into the root canal and pulp chamber to promote attachment. It is well established that immature teeth are effective targets for treatment. However, the indications for this treatment have not yet expanded sufficiently to encompass mature teeth with closed apical apex. In the present study, a mouse model of REPs in mature teeth was established, employing the maxillary first molar mesial root. μCT analyses disclosed that the distance from the occlusal surface to the physiological apex of the maxillary first molar mesial root in mice is 2.14 mm ± 0.08 mm, and the distance from the occlusal surface to the periapical alveolar bone is 2.46 mm ± 0.10 mm. Mesial root canal was treated with several sizes of k-files, and 15# k-file was identified as the most suitable k-file for use (P = 0.0007). During the regenerative process, spindle-shaped fibroblast-like cells, fibrous tissue formation, and mineralized tissue formation were identified on days 14 and 28. This study demonstrated that it is feasible to use the maxillary first molar mesial root as a REPs model for mature teeth and provided a detailed protocol and analysis of the healing process.</p>","PeriodicalId":19390,"journal":{"name":"Odontology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D-printed titanium enhances osteoblastic differentiation and extracellular matrix mineralization: insights from in vitro models.","authors":"Lucas Novaes Teixeira, Antônio Simões de Souza Filho, Camila Angela de Davi, Rafael Pes, Elizabeth Ferreira Martinez, Marcelo Henrique Napimoga","doi":"10.1007/s10266-025-01219-w","DOIUrl":"https://doi.org/10.1007/s10266-025-01219-w","url":null,"abstract":"<p><p>This study aimed to evaluate osteogenesis on the surface of three-dimensional (3D)-printed titanium (Ti). For this reason, mesenchymal stem cells (MSC) and osteoblastic-like cells cultures (Saos-2) were plated on 3D-printed Ti for up to 17 days. The following parameters were evaluated: 1) cell morphology; 2) cell viability and proliferation; 3) runt-related transcription factor-2 (RUNX2), type I collagen (COL I), osteopontin (OPN), bone sialoprotein (BSP), and osteocalcin (OC) gene expression; 4) COL I quantification; 5) alkaline phosphatase (ALP) activity, and 6) extracellular matrix (ECM) mineralization. Machined Ti samples were used as control. The data were analyzed statistically, considering a significant level of 5%. The findings of the study revealed that the surface characteristics of 3D-printed Ti allowed adhesion and proliferation of MSC and Saos-2 similarly as observed for both cultures grown on Machined Ti (p>0.05). However, Saos-2 cultured on 3D-printed Ti exhibited significantly higher ALP activity (p<0.05), whereas no difference was observed for MSC (p>0.05). Additionally, both cell types showed upregulation of osteogenic gene expression (including RUNX2, COL I, OPN, and BSP), increased COL I secretion, and enhanced ECM mineralization compared to those grown on Machined Ti (p<0.05). In conclusion, 3D-printed Ti significantly enhances osteoblastic differentiation in MSC and Saos-2 cultures. It promotes a higher expression of genes linked to bone growth and extracellular matrix mineralization, offering distinct advantages over traditionally Machined Ti. These outcomes highlight the promising potential of 3D-printed Ti for promoting osteogenesis, indicating its suitability for bone tissue engineering applications and advancement in bone regeneration strategies.</p>","PeriodicalId":19390,"journal":{"name":"Odontology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on bubble fluid dynamics of ultrasound-activated irrigation in apical region of root canal.","authors":"Yue Wang, Yi-Chen Zhu, Jin Zhu, Yu-Wei Sun, Min-Di Zhang, Yu-Hong Liang","doi":"10.1007/s10266-025-01195-1","DOIUrl":"https://doi.org/10.1007/s10266-025-01195-1","url":null,"abstract":"<p><p>The mechanism of fluid dynamics is essential for the rational clinical application of the root canal irrigation technique. This study aimed to explore the dynamic characteristics of bubble fluid in the apical canal during ultrasound-activated irrigation. Ultrasound-activated irrigation was performed in canal models with different sizes as group #30/0.04 and #30/0.06. High-speed flow visualization technology was used to capture real-time images at 4000 frames per second. The air bubble behavior in the apical region was observed and analyzed via ImageJ and MATLAB software. The bubble movement distance and the bubble lock formation time and length were recorded. The dimensionless cavitation area was calculated. Fluid activated by ultrasound in the apical canal presented initiation, growth and stability stages. In stage initiation, numerous small cavitation bubbles were generated within 1 ms at the file tip. Concurrent with small bubble generation, certain bubbles underwent coalescence, forming individual larger bubbles approximately 100 μm in diameter within 1 s. The presence of multiscale-size bubbles from micrometres to millimetres indicated the stage growth. Fate of most bubbles ended up with collapse, while aggregation was captured. When the large bubble diameter reached the root canal diameter, new small bubbles could not break and pass through the bubble layer. This was denoted as the bubble lock formation and stage stability starting at 9.80 ± 2.74 s in group #30/0.06 and 5.00 ± 2.26 s in group #30/0.04 (P < 0.05). Taper size of the root canal could influence the bubble fluid dynamics during ultrasound-activated irrigation. Larger canal taper with an apical diameter of 0.30 mm significantly prolonged bubble lock formation time and enhanced apical bubble movement distance during ultrasound-activated irrigation.</p>","PeriodicalId":19390,"journal":{"name":"Odontology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the anti-fibrotic effect of thymoquinone in the management of oral submucous fibrosis.","authors":"Aiman Asif, Nadia Naseem, Tasleem Akhtar, Usman Aftab, Ali Rafi, Safdar Hussain, Muhammad Shahzad","doi":"10.1007/s10266-025-01206-1","DOIUrl":"https://doi.org/10.1007/s10266-025-01206-1","url":null,"abstract":"<p><p>Oral submucous fibrosis (OSMF) is a potentially malignant disorder. Since decades, many treatment modalities have been in use but complete regression is still not achieved. This study evaluated the therapeutic effects of thymoquinone in OSMF and compared its effects with lycopene. OSMF model was established by administering bleomycin (1 mg/ml) into rats buccal mucosa for 8 weeks. Thymoquinone (25 mg/kg) and lycopene (5 mg/kg) were given to rats with OSMF and changes in body weight, mouth opening, gross morphological appearance of oral mucosa, and inflammatory cells count, antioxidant enzymes activity and mRNA expression of collagen type I and III were evaluated. Histological changes in buccal tissue were evaluated by H&E, Van Gieson and Masson's trichrome staining. Thymoquinone significantly increased the body weight and mouth opening which was reduced in diseased group. It also increased antioxidant enzymes activity. It alleviated signs of disease as gross morphological score was reduced. It also reduced the inflammatory cells count, expression of collagen type I and III and pathological features of disease. Thymoquinone can be a promising agent against OSMF and it acts by regulating inflammation, oxidative stress and especially fibrosis by lowering collagen type I and III deposition in extracellular matrix.</p>","PeriodicalId":19390,"journal":{"name":"Odontology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145177129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can chatbots replace experts? Diagnostic accuracy of AI models in classifying impacted mandibular third molars.","authors":"Müfide Bengü Erden, Mehmet Gümüş Kanmaz, Genta Agani Sabah","doi":"10.1007/s10266-025-01214-1","DOIUrl":"https://doi.org/10.1007/s10266-025-01214-1","url":null,"abstract":"<p><p>Artificial intelligence (AI)-based chatbots are increasingly employed in various fields of dentistry. However, their capability to interpret panoramic radiographs and classify impacted mandibular third molars has not yet been systematically evaluated. This study aimed to assess the diagnostic performance of four widely used large language model-based chatbots in this context. A total of 93 impacted mandibular third molars were assessed using panoramic radiographs. Four chatbots-ChatGPT-4o, Gemini 2.5 Pro, Claude Sonnet 4.0, and Copilot (GPT-4)-were asked to classify each case according to the Pell and Gregory, Winter, and Rood and Shehab systems without any additional guidance. Three experts then rated each chatbot response using a Global Quality Score. Inter-rater reliability and diagnostic agreement were analyzed. Inter-rater agreement was high among human evaluators (ICC: 0.886-0.935, p < 0.001). No significant difference was found in GQS ratings across the chatbots (p > 0.05), although ChatGPT-4o received the highest mean score (2.41 ± 1.03). ChatGPT-4o also performed significantly better in the Winter classification (κ = 0.171; p = 0.005). Gemini 2.5 Pro showed moderate agreement in root-related findings, whereas Copilot (GPT-4) showed more consistency in canal-related parameters (p < 0.05). No chatbot demonstrated acceptable agreement in the Pell and Gregory classification (p > 0.05). While AI-based chatbots showed potential for interpreting panoramic images, their current performance in third molar classification remains suboptimal at present. ChatGPT-4o outperformed other models in certain tasks, but none achieved expert-level accuracy. Further improvements, particularly with multimodal AI models and labeled datasets, are essential for future clinical integration.</p>","PeriodicalId":19390,"journal":{"name":"Odontology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erosive potential of Kombuchas: an in vitro study in an oral cavity simulator.","authors":"Débora Nunes de Oliveira Racki, Fernanda Fedatto, Rodrigo Alex Arthur, Tamires Timm Maske, Luana Severo Alves, Marisa Maltz","doi":"10.1007/s10266-025-01210-5","DOIUrl":"https://doi.org/10.1007/s10266-025-01210-5","url":null,"abstract":"<p><p>Kombucha is a fermented, sweet and acidic beverage, belonging to the functional beverage market. This study aimed to evaluate the erosive potential of Kombucha against dental hard tissues using an erosion/abrasion (EA) cycling promoted by a new laboratory multifunctional oral cavity simulator (MOCS). This in vitro study used a preclinical simulator to evaluate surface loss (step height) in bovine enamel and dentin specimens. The study design comprised two brands of Kombucha commercially available in the Brazilian market (experiment 1, DÊVI Kombucha; experiment 2, Tao Kombucha), three groups (negative control/water; positive control/Coca-Cola; test group/Kombucha), and two teeth substrates (enamel and dentin), with nine specimens per group (108 in total). The EA cycling consisted of exposure 3x/day for 10 min to the solutions (0.25 mL/min); toothbrushing (abrasion) 2x/day with fluoridated dentifrice (NaF; 1100 ppm) and with a soft bristle toothbrush; constant flow of artificial saliva during the day (0.2 mL/min) and overnight (0.04 mL/min). After 5 days of EA cycling, dentin/enamel surface loss/step height was measured by optical profilometry. Regarding the tested Kombuchas, DÊVI induced less surface loss than Coca-Cola, whereas the surface loss induced by Tao and Coca-Cola was similar. All tested drinks induced greater surface loss than the negative control. Among the substrates, surface loss was lower in dentin. In conclusion, this study demonstrated that the Kombuchas tested may have erosive potential causing significant loss of tooth structure. The regular consumption of Kombucha might expose dental hard tissues to an increased risk for erosive tooth wear.</p>","PeriodicalId":19390,"journal":{"name":"Odontology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of platelet concentrates on vital pulp treatment of fully developed and immature permanent teeth: a systematic review and network meta-analysis of human clinical trials.","authors":"Filippou Sofia, Kodonas Kostantinos, Fardi Anastasia, Gogos Christos","doi":"10.1007/s10266-025-01193-3","DOIUrl":"https://doi.org/10.1007/s10266-025-01193-3","url":null,"abstract":"<p><p>This systematic review and network meta-analysis compared the efficacy of platelet concentrates with traditional bioactive capping materials on vital pulp treatment (VPT) healing outcomes in permanent human teeth. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) checklist and a registered protocol (CRD42024614771), a search was conducted across PubMed, Web of Science, Scopus, ClinicalTrials.gov, and the Cochrane Library for studies published until March 31, 2025. Controlled clinical trials evaluating VPT success rates using platelet concentrates versus bioceramics in permanent teeth, with at least 6 months' follow-up, were included. Data from the selected studies were analyzed using the MetaInsight tool to assess multiple comparisons, and the risk of bias was evaluated using the Cochrane RoB2 and ROBINS-I tools. Evidence quality was graded using the Grading of Recommendations Assessment, Development and Evaluation approach (GRADE). The search identified 1097 studies, with ten meeting the inclusion criteria, encompassing 437 patients and three treatment modalities. At 6 months, success rates for mature teeth showed no statistically significant differences: LPC (RR = 1.00; 95% CI: 0.96-1.04) and PRF (RR = 1.04; 95% CI: 0.96-1.12). For immature teeth, PRF demonstrated no significant effect (RR = 0.99; 95% CI: 0.92-1.06). At 12 months, outcomes remained non-significant for mature teeth with LPC (RR = 1.02; 95% CI: 0.90-1.15) and PRF (RR = 1.10; 95% CI: 0.94-1.28), and for immature teeth treated with PRF (RR = 1.00; 95% CI: 0.94-1.06). These findings suggest that while platelet concentrates may offer comparable outcomes, bioceramics should be considered the preferred option based on probabilistic analysis.PROSPERO registration number: CRD42024614771.</p>","PeriodicalId":19390,"journal":{"name":"Odontology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145131532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}