Odontology最新文献

{"title":"Effect of tricalcium silicate-based intracanal dressing on bone resorption and inflammatory mediators in periapical lesions: a randomized controlled clinical trial.","authors":"Oğuzhan Ünal, Meltem Sümbüllü, Esra Laloğlu","doi":"10.1007/s10266-025-01093-6","DOIUrl":"10.1007/s10266-025-01093-6","url":null,"abstract":"<p><p>This study aimed to investigate the effect of tricalcium silicate- and calcium hydroxide-based intracanal dressing on the release of nuclear factor kappa B ligand (RANKL), osteoprotegerin (OPG), tumor necrosis factor-alpha (TNF-α), prostaglandin-E2 (PGE-2), and transforming growth factor-beta (TGF-β) in asymptomatic periapical lesions. The 60 patients included in the study were randomly divided into two groups according to the intracanal dressing. After removing gutta-percha from the root canals, RANKL, OPG, TNF-α, PGE-2, and TGF-β samples were obtained from the apical tissues using three paper cones and the selected dressing material was placed into the canals. In the second appointment, the dressing was removed, and the second samples were taken using the same method. Pre-treatment and post-treatment RANKL, OPG, TNF-α, PGE-2, and TGF-β levels were determined using an enzyme-linked immunosorbent assay test. Data were analysed using t-test, the Mann-Whitney U test, the Wilcoxon test, The Fisher-Freeman-Halton test, and Path analysis. No significant difference was found between the groups in terms of demographic variables (age, gender, tooth region, and smoking) (p > 0.05). There was a statistically significant decrease in RANKL/OPG, TNF-α, PGE-2, and TGF-β levels before and after treatment in both groups (p < 0.05). A significant difference was observed in the percentage change of RANKL/OPG, TNF-α, and TGF-β ratios between the groups (p < 0.05). A statistically higher decrease in RANKL/OPG, TNF-α, and TGF-β levels was observed in the calcium hydroxide-based intracanal dressing group (p < 0.05). No significant difference was observed between the groups in terms of PGE-2 percentage change (p > 0.05). Tricalcium silicate-based intracanal dressing effectively reduced RANKL/OPG, TNF-α, PGE-2, and TGF-β levels in periapical lesions, but calcium hydroxide-based intracanal dressing resulted in a higher percentage reduction in RANKL/OPG, TNF-α, and TGF-β levels. The effects of both medicaments on PGE-2 levels were similar.Trial registration The study was registered in clinical trials database on 12 March 2024 ( https://www.clinicaltrials.gov ). Registration number: NCT06307678.</p>","PeriodicalId":19390,"journal":{"name":"Odontology","volume":" ","pages":"1667-1677"},"PeriodicalIF":2.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12450833/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143743213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of chronic alcohol consumption on inflammatory response and periapical bone resorption in induced apical periodontitis: a systematic review of animal studies.","authors":"Isabel Silva Martins, Natália Pestana de Vasconcelos, Américo Santos Afonso, Ana Cristina Braga, Irene Pina-Vaz","doi":"10.1007/s10266-025-01122-4","DOIUrl":"10.1007/s10266-025-01122-4","url":null,"abstract":"<p><p>Alcohol consumption is linked to reduced bone mass and strength due to an imbalance in bone remodeling, characterized by decreased bone formation and an increased inflammatory response. Apical periodontitis affects the tissues surrounding the teeth and may also influence the systemic immune response by altering inflammatory marker levels. This systematic review examined how alcohol consumption affects the severity of experimental apical periodontitis in animal models. Following PRISMA guidelines, studies were sourced from three databases (PubMed, Scopus, and Web of Science) up to January 26, 2025. The included studies analyzed inflammation and/or bone resorption in animals with induced apical periodontitis, comparing alcohol-exposed groups to well-defined controls. Study quality was evaluated using the Animal Research: Reporting of In Vivo Experiments (ARRIVE) guidelines and the risk of bias was analyzed using the Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE) tool. Of 135 screened records, 7 studies met the inclusion criteria. These studies were of moderate quality with a moderate risk of bias. Findings revealed that chronic alcohol consumption exacerbates inflammation and bone resorption in rats with experimental apical periodontitis, with effects increasing in a dose-dependent manner. The evidence suggests that chronic alcohol consumption amplifies the periapical inflammatory response in animal models, potentially accelerating apical periodontitis progression. These results highlight the need for further prospective studies to explore the broader implications of alcohol consumption in the context of apical periodontitis. This systematic review is registered on the International Prospective Register of Systematic Reviews (PROSPERO; CRD42024589226).</p>","PeriodicalId":19390,"journal":{"name":"Odontology","volume":" ","pages":"1404-1414"},"PeriodicalIF":2.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12450794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of salivary mmp-8 gene polymorphism with its protein expression in oral submucous fibrosis patients.","authors":"Rida Qamar, Ambrina Khatoon, Talat Mirza, Afifa Razi, Yamna Khurshid","doi":"10.1007/s10266-025-01074-9","DOIUrl":"10.1007/s10266-025-01074-9","url":null,"abstract":"<p><p>OSF (Oral submucous fibrosis) is a chronic disease characterized by inflammation and progressive fibrosis of the submucosal tissues with the potential to progress into OSCC (Oral squamous cell carcinoma). Matrix metalloproteinases (MMP) are endopeptidases that play a role in extracellular matrix remodeling and pathophysiology of various diseases. The study aims to evaluate the gene polymorphism and protein expression of MMP-8 and their association with the severity of OSF. The cross-sectional study design involves patients diagnosed with OSF. DNA was extracted from saliva samples by the CTAB method followed by PCR and Sanger sequencing. The sequences were examined for MMP-8 polymorphism on Mega X software. ELISA was performed to assess the MMP-8 protein expression. The results of genetic polymorphism showed the alleles AG (rs11225395), TT (rs1861602574), CC (rs562617158), TT (rs2133511737), AA (rs1307439859), and CC (rs2133511706) consistent with disease severity. MMP-8 protein levels decreased with disease progression. Meanwhile, the association between the two showed a noteworthy significance with the presence of specific genetic variants, namely rs1320632, rs2133511732, rs1307439859, and rs2133511737, rs1307439859, rs562617158, rs11225395 shows a robust association with changes in MMP-8 protein expression. This study suggests a strong association between genotype and the modification of MMP-8 protein expression. In conclusion, MMP-8 may serve as a diagnostic biomarker in OSF.</p>","PeriodicalId":19390,"journal":{"name":"Odontology","volume":" ","pages":"1491-1501"},"PeriodicalIF":2.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143493156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of confocal laser scanning microscopy to evaluate the metal ion removal and destabilization of Enterococcus faecalis biofilms by EDTA and etidronic acid.","authors":"Talita Tartari, Carlos Estrela, Larissa Barbosa Borges de Araújo, Márcia Sirlene Zardin Graeff, Flaviana Bombarda de Andrade, Marco Antonio Hungaro Duarte","doi":"10.1007/s10266-025-01082-9","DOIUrl":"10.1007/s10266-025-01082-9","url":null,"abstract":"<p><p>Chelating substances bind to metals, forming stable complexes, rendering these essential ions unavailable for microbial metabolism and community stability in biofilms. This action can contribute to the disinfection in endodontic treatments. Through confocal laser scanning microscopy (CLSM), this study quantified the metal ion removal by chelating agents in Enterococcus faecalis biofilms and assessed the impact on community stability. E. faecalis biofilms were grown for 21 days on acrylic coverslips, which the following were immersed in (n = 10): G1) saline solution (control, 5 min); G2) 17% ethylenediaminetetraacetic acid (EDTA, 3 min); and G3) 9% etidronic acid (Dual Rinse HEDP, 5 min). Next, they were stained with Phen Green FL to identify metals, 4',6-diamidino-2-phenylindole (DAPI) to highlight bacterial DNA, and propidium iodide (PI) to mark nucleic acid in cells with damaged membranes. Images were captured (4/sample) by CLSM and analyzed by the software Leica Application Suite X. The individual and total volume of the biofilm-stained components (µm³) and their individual percentages in the biofilms were analyzed using one-way ANOVA with Tukey tests (α < 0.05). EDTA caused a higher metal removal (P < 0.05) that potentially destabilized biofilms, causing detachment of bacterial cells. Consequently, EDTA significantly reduced the total cubic volume of biofilms compared to other irrigants (P < 0.05), while control and etidronic acid groups exhibited similarity (P > 0.05). However, the percentages of nucleic acid and metals remained constant in all treatments (P > 0.05). In conclusion, strong chelating solutions, such as EDTA, can remove substantial amounts of metals from biofilms and affect the community stability.</p>","PeriodicalId":19390,"journal":{"name":"Odontology","volume":" ","pages":"1573-1581"},"PeriodicalIF":2.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serotype and distribution of adhesion genes in Streptococcus mutans isolated from people with Parkinson's disease.","authors":"Laura Donnet, Olivier Claisse, Johan Samot","doi":"10.1007/s10266-025-01078-5","DOIUrl":"10.1007/s10266-025-01078-5","url":null,"abstract":"<p><p>The delicate balance of the oral cavity is disrupted by changes in hygiene and diet, leading to caries. The virulence of Streptococcus mutans, a key caries pathogen, is partly explained by its rhamnose-glucose polysaccharide (RGP) and its sucrose-dependent and -independent adhesion mechanisms. Given their role in comorbidities, this study investigates the diversity of S. mutans through analysis of RGP and sucrose-independent adhesion proteins (SpaP, WapA, Cnm, Cbm) in Parkinson's disease patients. In the PARKIDENT clinical trial, strains were isolated from saliva samples of Parkinson's patients at baseline and during a follow-up visit. Strains were preanalyzed by multiplex PCR for serotype and collagen-binding proteins, followed by high-throughput sequencing and bioinformatics analysis using RAST® and BLAST®. Phylogenetic analyses and protein modeling were also conducted. Of 40 patients in the Parkident clinical trial, only 24 had Streptococcus mutans strains isolable from salivary swabs. Serotyping revealed that over 80% of the 44 strains isolated were serotype c, in line with prevalence data in the literature. Furthermore, only SpaP types A and B were identified in the strains. The low variability observed for the WapA protein underlines its functional importance. Finally, the cbm gene was not found in any strain, and only 5 strains possessed the cnm gene, all of them serotype c. The study of these 44 Streptococcus mutans strains showed characteristics similar to other populations. Serotype c predominates, with minimal peptide sequence variability in adhesion proteins (SpaP, WapA). Collagen-binding proteins Cnm and Cbm are rare or absent. Further research is essential to better characterize strain distribution in the Parkinson's-affected population due to S. mutans' growing role in extra-oral pathologies. Trial registry: ClinicalTrials.gov ID NCT03827551, First submitted: 2019-01-25.</p>","PeriodicalId":19390,"journal":{"name":"Odontology","volume":" ","pages":"1520-1532"},"PeriodicalIF":2.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy of CBCT with blooming artifact reduction filter on the measurements of dentin thickness in root canals with radiodense materials: an in vitro study.","authors":"Diego Leonardo de Souza, Luiz Carlos de Lima Dias Junior, Elimar Fernando Bauer, Cleonice da Silveira Teixeira, Lucas da Fonseca Roberti Garcia, Eduardo Antunes Bortoluzzi","doi":"10.1007/s10266-025-01099-0","DOIUrl":"10.1007/s10266-025-01099-0","url":null,"abstract":"<p><p>The precision of dentin thickness evaluations in the presence of artifacts is vital, as inaccuracies may increase the risk of over-preparation and consequent structural damage to the tooth. The purpose of this in vitro study was to evaluate the accuracy of residual dentin thickness measurements in CBCT images of teeth with high-density intracanal materials, utilizing the blooming artifact reduction (BAR) filter. Twelve single-rooted human teeth were selected. Axial cuts were performed, and the root thickness was measured at the buccal, lingual, mesial, and distal surfaces, which represented the reference standard. CBCT scans were acquired of each specimen in 5 different settings: empty root canals (ERC), gutta-percha cone (GPC), gutta-percha and endodontic sealer (GPC + S), fiberglass post (FGP), and metal post (MP). Measurements were performed before and after the application of the BAR filter in the e-vol DX software. ANOVA with the Dunnet's post hoc test was used for comparison between measurements in CBCT images and the reference standard. The BAR filter did not influence the measurements in teeth with ERC, GPC, and FGP (p > 0.05). In teeth with GPC + S, the measurements with the BAR filter had no difference from the reference standard (p < 0.05). CBCT images measurements were comparable to the reference standard in the ERC, GPC, and FGP groups. BAR filter was restricted to the GPC + S group in the cervical third, and the MP group in the apical third. In root canals with metal posts, the overall dentin thickness was significantly underestimated in all CBCT images within the cervical and middle thirds.</p>","PeriodicalId":19390,"journal":{"name":"Odontology","volume":" ","pages":"1712-1721"},"PeriodicalIF":2.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of air-thinning a two-step adhesive layer on bond strength to tooth substrates.","authors":"Yuko Nagasawa, Yoshikazu Eda, Shigeki Matsumoto, Hiroshi Nakajima, Yasushi Hibino","doi":"10.1007/s10266-025-01098-1","DOIUrl":"10.1007/s10266-025-01098-1","url":null,"abstract":"<p><p>This study investigated the effect of air-thinning to a two-step adhesive (G2-BOND Universal) on the microtensile bond strength (µTBS) between bovine teeth (enamel, dentin) and a resin composite (G-ænial A'CHORD). The adhesive was applied with or without air-blowing before light curing on the bovine enamel and dentin surfaces finished using 320-grit SiC paper. After resin composite buildup, µTBS specimens (1.0 mm × 1.0 mm cross-sectional area) were fabricated. The µTBS values were determined 24 h, 4 weeks, and 6 months after the specimen preparation. Furthermore, the adhesive layer thicknesses were measured on the SEM photographs of the specimens' fractured site after the µTBS test. Except for the enamel specimens at 6 months, no significant differences were observed in µTBS determined at any time periods between specimens with and without air-blowing (p > 0.05). µTBS values in air-blown specimens increased from 24 h to 4 weeks, and the values in non-air-blown specimens were greater at 6 months than at 24 h. Specimens subjected to air-blowing showed significantly thinner adhesive layer than those without at any time periods (p < 0.05). Although air-blowing reduced adhesive layer thickness, it did not affect the bond strength except for the enamel specimens at 6 months.</p>","PeriodicalId":19390,"journal":{"name":"Odontology","volume":" ","pages":"1436-1446"},"PeriodicalIF":2.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biocompatibility of irrigation solutions to dental-derived mesenchymal stem cells in regenerative endodontic procedure: a systematic review of in vitro studies.","authors":"Lim Hui Ying, Mariam Abdullah, Natrah Ahmad Fuad, Lim Ghee Seong, Noor Hayati Azami, Nora Sakina Mohd Noor, Myrna Nurlatifah Zakaria","doi":"10.1007/s10266-025-01087-4","DOIUrl":"10.1007/s10266-025-01087-4","url":null,"abstract":"<p><p>Regenerative endodontic procedures (REPs) offer an alternative to apexification in necrotic immature permanent teeth, promoting continued root development and dentinal wall thickening. Success in REPs requires effective disinfection and the survival of dental-derived mesenchymal stem cells (DMSCs), such as dental pulp stem cells (DPSCs), stem cells from the apical papilla (SCAPs), and periodontal ligament stem cells (PDLSCs). This review investigates the biocompatibility of irrigation solutions, including sodium hypochlorite (NaOCl), ethylenediaminetetraacetic acid (EDTA), and chlorhexidine (CHX), on DMSCs. Following PRISMA guidelines, a comprehensive search was conducted in PubMed, Scopus, Web of Science, Cochrane, and SciELO, with the last update on March 4, 2024. Studies from January 2008 to April 2024 assessing viability, proliferation, migration, differentiation, and mineralization of DMSCs treated with NaOCl, EDTA, and CHX were included. The papers were selected using PICOS criteria and quality was assessed using the PRILE checklist and risk of bias with the Quality Assessment Tool for In Vitro Studies. Of 738 studies identified, 15 met inclusion criteria. The findings suggest that NaOCl and CHX exhibit lower biocompatibility towards DMSCs compared to EDTA. NaOCl and CHX are cytotoxic to DMSCs, while EDTA demonstrates favorable biocompatibility, promoting osteogenic differentiation and mineralization. This highlights potential implications for irrigant selection in regenerative procedures, as appropriate irrigants may enhance cellular survival and improve clinical outcomes.</p>","PeriodicalId":19390,"journal":{"name":"Odontology","volume":" ","pages":"1315-1329"},"PeriodicalIF":2.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heavy metal migration from dental filling materials to calcified oral tissues: an in vitro analysis using LIBS and ICP-MS techniques.","authors":"Mays S Tareq, Tagreed K Hamad","doi":"10.1007/s10266-025-01088-3","DOIUrl":"10.1007/s10266-025-01088-3","url":null,"abstract":"<p><p>This study used ICP-MS and LIBS techniques to assess element migration in healthy, caries-prone, and dental treatment materials in human teeth. The researchers also analyzed the accumulation of significant minerals and toxic elements in calcified tissues. The laser drilling process was monitored in vitro using spectral measurements of the ablated plasma. This study found that while non-mineralizing elements and organic materials increased in concentration, the shift from caries to healthy tooth material was distinguished by a decrease in calcium and phosphorus concentrations. The migration of elements over time, such as Al, Ba, Hg, Pb, and Sr, from dental restorative materials to the tooth matrix, can also be linked to the spatial distribution of these elements. The ICP-MS studies revealed that certain elements had moved from dental cavity fillings to the healthy area of the teeth. These analyses reveal high/low element concentrations inside the tooth matrix, allowing monitoring of mineralization of the hydroxyapatite matrix and element migration, as well as identification of disease states like dental caries.</p>","PeriodicalId":19390,"journal":{"name":"Odontology","volume":" ","pages":"1613-1623"},"PeriodicalIF":2.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LED light promoted synthesis of silver nanoparticle with red cabbage extract in clinical conditions and its dental applications.","authors":"Zeynep Aslı Güçlü, Nur Sultan Gundes, Nimet Temur, Ismail Ocsoy, Nilay Ildız","doi":"10.1007/s10266-025-01086-5","DOIUrl":"10.1007/s10266-025-01086-5","url":null,"abstract":"<p><p>Silver nanoparticles (Ag NPs) are effective universal germicides toward various pathogens. Herein, we developed synthesis of fast and stable Ag NPs with red cabbage extract (RCE) used as reducing and capping agent promoted by the LED light device used in clinics for dental polymerization and investigated their antimicrobial properties for dentistry purposes. We systematically explained the formation mechanism of anthocyanins (anth) directed, existing as main and predominant components in RCE, Ag NPs (anth@Ag NP) in 10 s (sn) under photoirradiation by LED light with a standard power mode (1000 mW/cm²). We tested anth@Ag NP as an effective cavity disinfectant and caries arresting agent with its enhanced antimicrobial property against model cariogenic pathogens including standard strains of Streptococcus mutans (S. mutans) ATCC 25275, Enterococcus faecalis (E. faecalis) ATCC 29212, Staphylococcus aureus (S. aureus) ATCC 29213, and Candida albicans (C. albicans) ATCC 90028. We claim that the anth@Ag NP can be doped into several dental materials polymerized by LED light for long-term antimicrobial properties toward dental infections.</p>","PeriodicalId":19390,"journal":{"name":"Odontology","volume":" ","pages":"1603-1612"},"PeriodicalIF":2.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12450806/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143664015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}