OdontologyPub Date : 2026-10-04DOI: 10.1007/s10266-026-01579-x
Hrudi Sundar Sahoo, B Grinath, N Nivethitaa V Menon, S Sreeya, S Julie Minerva
{"title":"Biomechanical effects of cavity preparation and restorative procedures on strain and bite force distribution in posterior teeth: a systematic review of experimental studies.","authors":"Hrudi Sundar Sahoo, B Grinath, N Nivethitaa V Menon, S Sreeya, S Julie Minerva","doi":"10.1007/s10266-026-01579-x","DOIUrl":"https://doi.org/10.1007/s10266-026-01579-x","url":null,"abstract":"<p><p>To systematically evaluate the biomechanical effects of cavity preparation and restorative procedures on cuspal strain, deflection, and load distribution in posterior teeth, while critically appraising methodological quality in experimental and computational models. This systematic review followed PRISMA guidelines and was prospectively registered in PROSPERO (CRD420251247979). Eligibility criteria included in vitro investigations on human posterior teeth evaluating primary biomechanical outcomes across varying cavity designs and restorative interventions. A comprehensive literature search was conducted through December 2025 across PubMed, Scopus, and Dentistry & Oral Sciences Source (EBSCO). Out of 612 identified records, 18 studies met the full eligibility criteria and were included in the qualitative synthesis. Cavity geometry and the extent of structural loss showed the most consistent association with increased cuspal strain and deformation across the included studies, while restorative materials, polymerization behavior, fiber reinforcement, and endodontic access design further modified the biomechanical response. Adhesively bonded restorations, bulk-fill systems, and selected fiber-reinforced strategies generally reduced cuspal deformation compared with non-adhesive restorations or conventional incremental approaches, although their effects varied according to material composition and placement protocol. However, these interventions did not fully offset the structural compromise caused by marginal ridge loss. While most studies demonstrated acceptable methodological quality, reporting gaps remain regarding sample size calculation and standardized aging protocols. Future research should prioritize dynamic in vivo loading models and advanced computational analyses incorporating proximal contacts and antagonist teeth to better translate biomechanical trends into clinical longevity.</p>","PeriodicalId":19390,"journal":{"name":"Odontology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149113009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
OdontologyPub Date : 2026-10-04DOI: 10.1007/s10266-026-01570-6
Zeynep Yağmur Özdemir Tekin, Arzu Kaya Mumcu
{"title":"Consistency and accuracy of different artificial intelligence models in evaluating longitudinal cracks and fractures of teeth.","authors":"Zeynep Yağmur Özdemir Tekin, Arzu Kaya Mumcu","doi":"10.1007/s10266-026-01570-6","DOIUrl":"https://doi.org/10.1007/s10266-026-01570-6","url":null,"abstract":"<p><p>Large language models such as ChatGPT and Google Gemini have attracted increasing attention in dentistry due to their potential to support clinical decision-making; however, their reliability in responding to endodontic questions remains unclear. This study compared the accuracy, consistency, and temporal stability of three artificial intelligence models (ChatGPT-3.5, ChatGPT-4o, and Google Gemini) when answering dichotomous clinical questions on vertical root fractures and tooth cracks using expert responses as the reference standard. Seventy-two true/false questions were developed based on the European Society of Endodontology position statement on longitudinal tooth fractures, and 60 validated items with an item-level content validity index of 1.00 were included and categorized into easy, moderate, and difficult levels. Each model was queried over 10 consecutive days at three daily time points, generating 5,400 responses in total. Overall accuracy differed significantly among models (p < 0.001), with ChatGPT-4o achieving the highest accuracy (86.1%), followed by ChatGPT-3.5 (85.6%) and Gemini (81.8%). No differences were observed between morning and afternoon sessions, whereas evening performance was significantly lower for Gemini (p = 0.011). Differences between models were evident only for moderate-difficulty questions (p < 0.001). Inter-model agreement was very low (Cohen's kappa (κ) = 0.019), and temporal stability differed significantly among models (p < 0.001), with ChatGPT-4o showing the highest stability. Although acceptable accuracy levels were observed, limited agreement and temporal variability indicate that these systems cannot replace clinician judgment and should currently be used only as supportive tools in endodontic decision-making.</p>","PeriodicalId":19390,"journal":{"name":"Odontology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149112133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
OdontologyPub Date : 2026-10-04DOI: 10.1007/s10266-026-01573-3
Kevser Karakaya, Gonca Deste Gökay, Seda Üstün Aladağ
{"title":"Evaluation of the effect of sandblasting and laser surface treatments on the shear bond strength of zirconia with different yttria content using resin cement.","authors":"Kevser Karakaya, Gonca Deste Gökay, Seda Üstün Aladağ","doi":"10.1007/s10266-026-01573-3","DOIUrl":"https://doi.org/10.1007/s10266-026-01573-3","url":null,"abstract":"<p><p>This in vitro study aimed to assess the effects of Al₂O₃ sandblasting and laser treatment, applied individually or in combination, on surface roughness, surface characterization, and shear bond strength (SBS) to resin cement after thermal aging of zirconia with yttria content of 3 mol% and 5 mol%. A total of 192 disk-shaped specimens (Ø12 × 1.2 mm) were prepared from 3Y-TZP (VITA YZ HT) and 5Y-TZP (VITA YZ XT) zirconia. For each zirconia material, specimens were assigned to eight surface-treatment conditions: 50 µm Al₂O₃ sandblasting (50S), 110 µm Al₂O₃ sandblasting (110S), Er,Cr:YSGG laser treatment (ER), nanosecond fiber laser treatment (FL), 50S+ER, 50S+FL, 110S+ER, and 110S+FL, forming 16 material-by-surface-treatment subgroups. In each subgroup, 10 specimens were included in the quantitative Ra and SBS analyses (n=10). These specimens were first evaluated for surface roughness using a 3D optical profilometer, then bonded with a self-adhesive resin cement (Panavia SA Cement Universal), subjected to 5,000 thermal cycles, and tested for SBS. Two additional specimens were prepared separately for descriptive surface characterization in each subgroup: one for atomic force microscopy (AFM) and one for scanning electron microscopy with energy-dispersive X-ray spectroscopy (SEM-EDS). These additional specimens were not included in the statistical sample size and were not subjected to the bonding procedure. Data were analyzed using two-way ANOVA, simple-effects analyses, Tukey HSD tests, and Bonferroni-adjusted material comparisons (α=.05). Surface treatment and the material × surface treatment interaction significantly affected both Ra and SBS (P<.05). The material main effect was significant for Ra (P=.033) but not for SBS (P=.471). After Bonferroni correction, no significant difference in Ra was observed between 3Y-TZP and 5Y-TZP for any individual surface treatment (P>.05). For 3Y-TZP, 50S+FL produced the highest mean SBS and yielded significantly higher values than ER, FL, 50S+ER, and 110S+FL (P<.05). For 5Y-TZP, ER produced significantly lower SBS than all other treatments (P<.05). Between-material comparisons showed higher SBS for 3Y-TZP in the ER group (P<.001) and higher SBS for 5Y-TZP in the 110S+FL group (P=.045). Sandblasted surfaces exhibited irregular pores, grooves, and abrasive marks, whereas laser-treated surfaces showed a shallower, more uniform topography. Crack-like defects and fissure-like separations were observed in both 110S+FL groups. The effects of surface treatment on Ra and SBS varied by zirconia material, and higher surface roughness did not consistently yield higher SBS. In 3Y-TZP, 50S+FL produced the highest mean SBS but did not differ significantly from 50S, 110S, or 110S+ER. In 5Y-TZP, ER yielded significantly lower SBS than all other treatments, whereas no significant differences were observed among the remaining seven protocols. Crack-like defects and fissure-like separations were observed in both 110S+FL group","PeriodicalId":19390,"journal":{"name":"Odontology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149112648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
OdontologyPub Date : 2026-10-04DOI: 10.1007/s10266-026-01565-3
Betül Tokat, Soley Arslan
{"title":"Evaluation of tooth sensitivity and whitening effects of tooth whitening agents containing calcium, hydroxyapatite and fluoride.","authors":"Betül Tokat, Soley Arslan","doi":"10.1007/s10266-026-01565-3","DOIUrl":"https://doi.org/10.1007/s10266-026-01565-3","url":null,"abstract":"<p><p>This randomized clinical trial evaluated the effects of hydrogen peroxide (HP)-based whitening agents containing calcium, hydroxyapatite, and fluoride on color change (ΔE₀₀), whiteness change (ΔWID), and post-whitening tooth sensitivity (TS). Sixty participants were randomly allocated to three groups (n = 20) and treated with different in-office whitening systems: Opalescence Boost (40% HP and fluoride), Whiteness HP Blue (35% HP and calcium), and Biowhiten ProOffice PowerHP (18% HP and hydroxyapatite). Color change was measured spectrophotometrically before treatment, immediately after treatment, and at 1, 2, 4, 8, and 16 weeks, as well as at 6 months and 1 year. Tooth sensitivity was assessed using the Numerical Rating Scale (NRS). Patient satisfaction was also evaluated using a questionnaire. ΔE₀₀ values showed significant differences among the groups at all evaluation periods except immediately after treatment and at 1 year (p < 0.05). ΔWID values demonstrated significant differences at all time points except at 2 weeks, 4 weeks, and 1 year (p < 0.05). Immediately after treatment, NRS scores were significantly lower in the HP18 group than in the HP40 group (p < 0.05), while the HP35 group did not differ significantly from either group. No significant differences among the groups were observed at the subsequent time points (p > 0.05). No significant difference was found in patient satisfaction scores (p = 0.728). Despite differences in hydrogen peroxide concentration and formulation characteristics, all whitening systems provided comparable whitening efficacy, tooth sensitivity outcomes, and patient satisfaction after 1 year. The study was conducted prospectively and registered retrospectively at ClinicalTrials.gov (NCT06855940) on February 25, 2025.</p>","PeriodicalId":19390,"journal":{"name":"Odontology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149112686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparison of treatment time and patient-reported outcomes between erythritol powder air-polishing and rubber cup polishing: a randomized crossover clinical trial.","authors":"Satoshi Sekino, Etsuko Murakashi, Tomohisa Ogawa, Yukihiro Numabe","doi":"10.1007/s10266-026-01567-1","DOIUrl":"https://doi.org/10.1007/s10266-026-01567-1","url":null,"abstract":"<p><p>Professional mechanical plaque removal (PMPR) is essential for the prevention of dental caries and periodontal diseases. Erythritol powder air polishing (EPAP) has recently gained attention as an alternative to conventional rubber cup polishing (RC); however, evidence regarding patient-reported outcomes (PROs), particularly using the cetylpyridinium chloride (CPC)-containing erythritol formulation available in Japan, remains limited. This randomized, single-center, two-period crossover clinical trial compared EPAP with RC in systemically healthy adults. Twenty-one participants received both interventions in a randomized sequence with a washout period of at least two weeks. The primary outcome was treatment time, while secondary outcomes included pain during treatment, taste, oral freshness, taste disturbance, discomfort, and overall treatment preference. Data were analyzed using linear mixed-effects models accounting for treatment, period, and sequence effects. Baseline plaque scores were comparable between interventions. EPAP required significantly less treatment time than RC, with adjusted mean treatment times of 438 s and 759 s, respectively, corresponding to a reduction of approximately 323 s (P < 0.001). No significant period or sequence effects were observed. No significant differences were detected between EPAP and RC for pain, taste, oral freshness, taste disturbance, discomfort, or overall treatment preference. Eleven participants preferred RC and ten preferred EPAP, with no significant difference in preference (P = 1.000). Within the limitations of this study, EPAP significantly improved the efficiency of supragingival plaque removal without compromising patient-reported outcomes or treatment acceptance. These findings support the use of the CPC-containing erythritol powder air-polishing system as an efficient alternative to conventional rubber cup polishing for professional supragingival biofilm management.</p>","PeriodicalId":19390,"journal":{"name":"Odontology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149112159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
OdontologyPub Date : 2026-10-04DOI: 10.1007/s10266-026-01566-2
Rana El-Qashty, Ahmed A Emam, Mona H El-Zekrid, Osama A Elkashty, Tarek Mohamed Abdelwahab, Noha Tharwat Abou El-Khier, Eman Gamal Sobh, Eman Hany
{"title":"Comparison of the effects of different dental pulp stem cell preconditioning protocols on the odontogenic potential of their derived small extracellular vesicles.","authors":"Rana El-Qashty, Ahmed A Emam, Mona H El-Zekrid, Osama A Elkashty, Tarek Mohamed Abdelwahab, Noha Tharwat Abou El-Khier, Eman Gamal Sobh, Eman Hany","doi":"10.1007/s10266-026-01566-2","DOIUrl":"10.1007/s10266-026-01566-2","url":null,"abstract":"<p><p>Regenerative endodontic therapy that is based on the use of stem cells or their derivatives to induce dentin-pulp complex regeneration has recently gained substantial interest. This study aimed to compare the effect of preconditioning through odontogenesis (OD) and/or low-level laser therapy photobiostimulation (LLLT) of human dental pulp stem cells (hDPSCs) on the regenerative potentials of their derived small extracellular vesicles (sEVs) aiming to develop a novel pulp capping therapy. In the current study, hDPSCs were subjected to OD, LLLT, or dual preconditioning protocols before the isolation of sEVs, then the derived sEVs were co-cultured with naïve hDPSCs. Cell viability and wound healing capacity were evaluated using MTT and scratch assays, respectively. RT-qPCR was performed for odontogenic gene expression (DSPP, DMP1, and COL1A1), followed by immunocytochemical staining. Matrix mineralization was also assessed, and relevant statistical analyses were performed. All sEVs-treated groups revealed enhanced cellular and odontogenic activities. OD-sEVs enhanced wound healing and mineralization, while LLLT-sEVs showed relatively higher viability, odontogenic gene and protein expression levels. However, no significant differences were detected between both groups. The novel dual preconditioning protocol surpassed either treatment alone representing a promising approach for odontogenic induction of mesenchymal stem cells. The results highlighted the regenerative potential of preconditioned sEVs as a biological, promising pulp capping material that could open new avenues in the field of regenerative endodontic treatment after being tested in-vivo in experimental animals.</p>","PeriodicalId":19390,"journal":{"name":"Odontology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149112028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
OdontologyPub Date : 2026-10-04DOI: 10.1007/s10266-026-01571-5
Elif Alkan, Zeynep Tuğçe Tağtekin, Şevval Nur Tarakçı, Hamit Enis Aslan, Ahmad Bittar, Bora Korkut, Dilek Tağtekin
{"title":"Effect of toothbrushing mode and brushing load on the wear of anterior tooth-shaped restorative composites.","authors":"Elif Alkan, Zeynep Tuğçe Tağtekin, Şevval Nur Tarakçı, Hamit Enis Aslan, Ahmad Bittar, Bora Korkut, Dilek Tağtekin","doi":"10.1007/s10266-026-01571-5","DOIUrl":"https://doi.org/10.1007/s10266-026-01571-5","url":null,"abstract":"<p><p>This in vitro study evaluated the effects of approximately duration-normalized toothbrushing protocols and brushing load on volumetric wear and surface roughness changes of anterior tooth-shaped restorative composite specimens. One hundred twelve specimens were prepared from two highly filled flowable and two paste-type composites in a balanced 2 × 2 × 2 × 2 factorial design. After finishing, polishing, and 10,000 thermal cycles, seven specimens were mounted per manual-brushing run and brushed for 60,000 carriage strokes at 165 strokes/min (total run approximately 364 min; nominal exposure approximately 52 min/specimen), whereas electric brushing was applied for 52 min/specimen. Both protocols were intended to approximate one year of tooth-specific brushing duration but were not mechanically equivalent. Specimens were tested under 1.96-2.94 N. Volumetric loss was assessed using Primescan-based three-dimensional superimposition, and arithmetic mean roughness was measured before and after brushing. Factorial multivariate analysis of variance and follow-up univariate analyses were used. Toothbrushing protocol and load significantly affected the combined outcomes (Pillai trace = 0.926 and 0.827, respectively; both p < 0.001). Under the approximately duration-matched but mechanically different protocols, electric brushing produced greater roughness difference and volumetric loss, and higher load increased both outcomes. The protocol × load interaction was significant for volumetric loss (F = 89.33, p < 0.001). Composite category and trademark were not significant. The findings do not isolate an intrinsic manual-versus-electric drive-mechanism effect.</p>","PeriodicalId":19390,"journal":{"name":"Odontology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149112472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
OdontologyPub Date : 2026-10-04DOI: 10.1007/s10266-026-01564-4
Akanay Copuroglu, Umur Davut, Ozge Doganay Ozyilmaz, Ozgun Yusuf Ozyilmaz
{"title":"Illuminant-dependent color inconstancy and metameric behavior of anodized titanium through silicone-based gingival simulation layers of varying thickness.","authors":"Akanay Copuroglu, Umur Davut, Ozge Doganay Ozyilmaz, Ozgun Yusuf Ozyilmaz","doi":"10.1007/s10266-026-01564-4","DOIUrl":"https://doi.org/10.1007/s10266-026-01564-4","url":null,"abstract":"<p><p>This in vitro study evaluated how gingival thickness and anodization color affect color perception of Grade V titanium discs under different light sources. Ninety-six titanium discs were anodized yellow, pink, or purple, or left non-anodized. Silicone gingival masks of 1 mm and 2 mm simulated soft tissue. A single spectral reflectance measurement was recorded for each specimen using a benchtop spectrophotometer, from which color coordinates under five standardized illuminants (D65, D50, A, F2, F11) were computationally derived. Color differences (ΔE₀₀) were calculated using the CIEDE2000 formula to evaluate color inconstancy, and metamerism was quantified using a CIEDE2000-based metamerism index (MI), the mean absolute difference between ΔE₀₀ under the test illuminants (D50, A, F2, F11) and D65. Data were analyzed with one-way ANOVA, Tukey HSD post hoc tests, and independent t-tests (α = 0.05). All anodized colors at 1 mm exceeded the CIEDE2000 clinical acceptability threshold (ΔE₀₀ >1.8), with purple showing the highest inconstancy, particularly under fluorescent lighting (P<.05). Increasing thickness to 2 mm significantly reduced ΔE₀₀ across all groups (P<.05), although values remained above the acceptability threshold in every group, with purple showing the greatest relative stability under all illuminants. Metameric behavior remained imperceptible under most conditions, except for pink at 1 mm under F2. Thickness and lighting significantly affect color stability of anodized titanium, although the effect of illuminant type was color-dependent: fluorescent (F2) illumination increased color inconstancy for purple and, at 2 mm, yellow, whereas pink showed the opposite pattern, with its lowest ΔE₀₀ values occurring under F2 rather than D65 at both thicknesses. Thinner tissue intensifies color shifts, while ≥ 2 mm thickness improves consistency. Pink performs better in thin tissue; purple shows greatest stability with thicker coverage. Metamerism was imperceptible under most conditions, except for pink at 1 mm under F2, which reached a perceptible but clinically acceptable level.</p>","PeriodicalId":19390,"journal":{"name":"Odontology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149112615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
OdontologyPub Date : 2026-10-01Epub Date: 2026-03-21DOI: 10.1007/s10266-026-01350-2
Mona Bahaa Morsy, Marwa M Abd Elhameed, Reham Ahmed Mohamed Abdrabo, Safaa Ismail Hussein
{"title":"The effect of individual sulfasalazine administration and in combination with esomeprazole on buccal mucosa of albino rats: histological, immunohistochemical, and molecular study.","authors":"Mona Bahaa Morsy, Marwa M Abd Elhameed, Reham Ahmed Mohamed Abdrabo, Safaa Ismail Hussein","doi":"10.1007/s10266-026-01350-2","DOIUrl":"10.1007/s10266-026-01350-2","url":null,"abstract":"<p><p>The study aims to investigate the effect of sulfasalazine (SFZN) individually and in combination with esomeprazole (ESOm) on the buccal mucosa of albino rats. SFZN is a widely used drug for the management of various autoimmune diseases which has been reported to cause renal injury in humans and a dose of 600 mg/kg/day has been described to cause renal injury in rats. ESOm is a commonly used proton pump inhibitor. Few studies have investigated their effects on oral and paraoral tissues. Three groups were designed out of 27 male albino rats. The control group was given distilled water, the SFZN group was given SFZN (600 mg/kg/day), and the ESOm group was given SFZN (600 mg/kg/day) and ESOm (30 mg/kg body weight); the drugs were dissolved in distilled water. The experiment was conducted for 14 days. Buccal mucosae were evaluated for keratin thickness, area % of iron deposition, area% of immunoreactivity to nuclear factor erythroid 2-related factor 2 (Nrf2) and glutathione (GSH) tissue level using one-way ANOVA and post hoc tests. The level of statistical significance was set at p < 0.05. SFZN individually has significantly increased keratin thickness, disrupted Nrf2 machinery and glutathione tissue level, while SFZN in combination with ESOm showed significant increase in area% of iron deposition. DNA degradation using comet assay was evaluated using Kruskal-Wallis and Dunn's test which revealed no significant difference of tail length and tail moment in SFZN group and ESOm group but these parameters were significantly different in these two groups in relation to the control group (p < 0.05).</p>","PeriodicalId":19390,"journal":{"name":"Odontology","volume":" ","pages":"2693-2703"},"PeriodicalIF":2.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13630826/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147494478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
OdontologyPub Date : 2026-10-01Epub Date: 2026-02-04DOI: 10.1007/s10266-026-01336-0
Hussain D Alsayed, Islam G Shahin, Noha M Anany, Mohamed I El-Anwar, Tarek M Elshazly, Abdulaziz Alhotan
{"title":"Comparative numerical finite element analysis of tooth-implant- versus implant-implant-supported three-unit fixed prostheses under oblique loading.","authors":"Hussain D Alsayed, Islam G Shahin, Noha M Anany, Mohamed I El-Anwar, Tarek M Elshazly, Abdulaziz Alhotan","doi":"10.1007/s10266-026-01336-0","DOIUrl":"10.1007/s10266-026-01336-0","url":null,"abstract":"<p><p>To investigate the biomechanical performance of fixed dental prostheses supported by either tooth-implant or implant-implant configurations, fabricated from zirconia or polyetherketoneketone (PEKK), under oblique loading using three-dimensional finite element analysis (FEA). Three mandibular posterior models were developed: M1 (implant at the first molar and natural tooth at the first premolar), M2 (implant at the first premolar and natural tooth at the first molar), and M3 (implants at both the first premolar and first molar). Each model was restored with a three-unit prosthesis fabricated from either zirconia or PEKK. The digital workflow included anatomical segmentation using Mimics software, refinement of bone and soft tissues with 3-Matic software, and integration of implants, abutments, and prosthetic components, followed by meshing and FEA using ANSYS software. All models were subjected to oblique loading of 50 N at 30° and 45°, and von Mises stress and deformation were recorded. M3 exhibited the most favorable biomechanical behavior, showing the lowest von Mises stress across almost all components. The hybrid tooth-implant models (M1 and M2) showed higher stress concentrations, particularly M2 with PEKK (loading angle 45°), which recorded the highest implant stress (312 MPa) and the greatest deformation (75 µm). The highest screw stress was recorded in M1 with PEKK, reaching 483 MPa. Zirconia exhibited higher stress within the prosthesis, but lower deformation, whereas PEKK resulted in greater deformation in the tooth and periodontal ligament (PDL). Implant-implant-supported prostheses showed the most favorable biomechanical behavior under oblique loading. Tooth-implant models, especially with anterior implant placement, exhibited higher stress and deformation. Zirconia offered greater rigidity and dimensional stability, while PEKK provided better stress dissipation but required careful design to manage its flexibility.</p>","PeriodicalId":19390,"journal":{"name":"Odontology","volume":" ","pages":"2648-2657"},"PeriodicalIF":2.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13630901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146119553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}