María Jiménez Aceituno, Ana Segarra Balao, Juan de Dios Barranco Ochoa
{"title":"[Chronic hyponatremia secondary to drug-induced syndrome of inappropriate antidiuretic hormone secretion - The role of oral urea as a safe and effective therapeutic alternative].","authors":"María Jiménez Aceituno, Ana Segarra Balao, Juan de Dios Barranco Ochoa","doi":"10.20960/nh.07102","DOIUrl":"10.20960/nh.07102","url":null,"abstract":"<p><strong>Introduction: </strong>Introduction: hyponatremia is one of the most common electrolyte disturbances in clinical practice. Among the causes of euvolemic hyponatremia, syndrome of inappropriate antidiuretic hormone secretion (SIADH) is one of the most prevalent etiologies, with medications being one of its common triggers. Case report: we present the case of a 71-year-old woman with chronic euvolemic hyponatremia secondary to drug-induced SIADH, in the context of ongoing treatment with multiple potentially implicated medications. Discussion: the significance of this case lies in demonstrating the efficacy and safety of oral urea as a maintenance treatment in a patient for whom discontinuation of the causative medications was not possible due to the need for chronic psychopharmacological treatment. It also illustrates the profile of a patient who is a candidate for treatment with oral urea: chronic euvolemic hyponatremia secondary to SIADH, in which fluid restriction is not feasible, and other therapeutic alternatives presented limitations.</p>","PeriodicalId":19385,"journal":{"name":"Nutricion hospitalaria","volume":" ","pages":"24-27"},"PeriodicalIF":1.3,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148900992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Management of syndrome of inappropriate antidiuretic hormone secretion in outpatients].","authors":"Juan Fernández Jiménez","doi":"10.20960/nh.07099","DOIUrl":"10.20960/nh.07099","url":null,"abstract":"<p><strong>Introduction: </strong>Introduction: the syndrome of inappropriate antidiuretic hormone secretion (SIADH) is the most frequent cause of hyponatremia in the outpatient setting, presenting significant diagnostic and therapeutic challenges due to the difficulty of performing laboratory monitoring and poor patient compliance with fluid restriction. Case report: we report the case of an institutionalized and polymedicated 59-year-old male, with a history of congenital epilepsy, who developed moderate euvolemic hyponatremia ([Na+] 124 mEq/l) secondary to oxcarbazepine therapy. Given the risk of a progressive decline in serum sodium, treatment with oral urea (30 g/day) was initiated, achieving a controlled and progressive increase in natremia to safe limits (133 mEq/l), even before the withdrawal of the culprit drug. Following the subsequent discontinuation of oxcarbazepine by neurology, natremia fully normalized ([Na+] 138 mEq/l), allowing a successful withdrawal of urea. Discussion: oral urea stands out as the only fully effective, safe, and well-tolerated medium- and long-term therapeutic strategy available for managing outpatient SIADH.</p>","PeriodicalId":19385,"journal":{"name":"Nutricion hospitalaria","volume":" ","pages":"11-14"},"PeriodicalIF":1.3,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148900868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Chronic hyponatremia due to syndrome of inappropriate antidiuretic hormone secretion in an elderly patient with chronic obstructive pulmonary disease: Favorable response to oral urea].","authors":"Amaya Morales Jaurrieta, María Miguélez-González","doi":"10.20960/nh.07110","DOIUrl":"10.20960/nh.07110","url":null,"abstract":"<p><strong>Introduction: </strong>Introduction: syndrome of inappropriate antidiuretic hormone secretion (SIADH) is the leading cause of euvolemic hypoosmolar hyponatremia and represents a therapeutic challenge in elderly patients. Case report: we report an 81-year-old woman with severe chronic obstructive pulmonary disease (COPD) and depressive disorder treated with drugs potentially associated with SIADH, who developed chronic euvolemic hyponatremia. Discussion: fluid restriction and oral sodium supplementation were ineffective. Tolvaptan induced a rapid increase in serum sodium and was discontinued due to risk of overcorrection. Subsequently, oral urea (15 g/day) maintained serum sodium levels within the normal range throughout follow-up. In conclusion, this case supports oral urea as an effective, safe, and cost-efficient therapeutic option for chronic SIADH, particularly in elderly patients in whom vasopressin V2 receptor antagonists may carry a risk of overly rapid correction.</p>","PeriodicalId":19385,"journal":{"name":"Nutricion hospitalaria","volume":" ","pages":"53-55"},"PeriodicalIF":1.3,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148900949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Fluctuating hyponatremia following transsphenoidal surgery ‒ \"The challenge of correcting without going too far\"].","authors":"Elena Vera Tuñón, Luis Casamayor Escrivá","doi":"10.20960/nh.07105","DOIUrl":"10.20960/nh.07105","url":null,"abstract":"<p><strong>Introduction: </strong>Introduction: sodium disorders following pituitary represent one of the most common complications. Differential diagnosis between syndrome of inappropriate antidiuretic hormone secretion (SIADH) and a triphasic response is critical to avoid overcorrection. Case report: we report a case of a 58-year-old male who underwent surgery for a pituitary macroadenoma and developed a triphasic response: initial polyuria, followed by transient SIADH. Due to a suboptimal response to fluid restriction and the risk of transitioning to a new polyuric phase, oral urea (30 g/day) was started. Gradual and safe sodium correction was achieved (128 to 132 mmol/l in 36 h), allowing early detection of the final shift back to diabetes insipidus without exceeding safety limits. Discussion: all in all, oral urea is an effective alternative for postoperative SIADH, providing more predictable and reversible osmotic control in scenarios of fluctuating natremia.</p>","PeriodicalId":19385,"journal":{"name":"Nutricion hospitalaria","volume":" ","pages":"31-34"},"PeriodicalIF":1.3,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148900593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ingrid Béjar Vasquez, Kiara Berenis Céspedes Luján
{"title":"[Carbohydrate quality, its relationship with sleep and depression in patients with type 2 diabetes].","authors":"Ingrid Béjar Vasquez, Kiara Berenis Céspedes Luján","doi":"10.20960/nh.06929","DOIUrl":"https://doi.org/10.20960/nh.06929","url":null,"abstract":"","PeriodicalId":19385,"journal":{"name":"Nutricion hospitalaria","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148813726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Associations of cumulative exposure and control patterns of the single-point insulin sensitivity estimator with incident cardiovascular disease in middle-aged and older Chinese adults with dysglycemia.","authors":"Hao Li, Lingyan Hu, Chuanxin Zou","doi":"10.20960/nh.06792","DOIUrl":"https://doi.org/10.20960/nh.06792","url":null,"abstract":"<p><strong>Objective: </strong>the single-point insulin sensitivity estimator (SPISE) is a novel insulin resistance marker; however, the longitudinal impacts of cumulative SPISE (cuSPISE) and its control patterns on cardiovascular disease (CVD) remain unclear. We investigated the associations of SPISE, cuSPISE, and its longitudinal control patterns with incident CVD in middle-aged and older adults with dysglycemia (diabetes or prediabetes).</p><p><strong>Methods: </strong>data were obtained from the China Health and Retirement Longitudinal Study (CHARLS). Long-term SPISE exposure and its longitudinal control patterns were characterized using cuSPISE and k-means clustering. Multivariable Cox models, restricted cubic splines (RCS), subgroup, and mediation analyses were employed to evaluate the associations between SPISE and incident CVD.</p><p><strong>Results: </strong>during a median 5-year follow-up of 2,598 participants, 575 incident CVD cases were identified. SPISE and cuSPISE were inversely associated with CVD risk. Compared with the lowest cuSPISE quartile (Q1), the highest (Q4) showed a 40 % lower risk (HR = 0.60; 95 % CI: 0.44-0.81; p for trend < 0.001). RCS analysis further confirmed this inverse relationship. Furthermore, well-controlled group (HR = 0.74; 0.55-0.99, p = 0.048) and moderately-controlled group (HR = 0.80; 0.65-0.98, p = 0.031) trends were associated with lower CVD incidence than the poorly-controlled group (Cluster 3). White Blood Cell (WBC) mediated 4.49 % of the cuSPISE-CVD association. Findings remained consistent across subgroups.</p><p><strong>Conclusion: </strong>our findings suggest that higher SPISE and cuSPISE levels, along with well-controlled or moderately-controlled groups, are associated with a reduced risk of CVD. These results suggest that longitudinal monitoring of SPISE may provide valuable insights for CVD risk stratification among middle-aged and older populations with dysglycemia.</p>","PeriodicalId":19385,"journal":{"name":"Nutricion hospitalaria","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148813816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alan E Guzmón-León, Katja Stein, Humberto Astiazaran-García, Mauro E Valencia, Trinidad Quizán-Plata, Verónica López-Teros
{"title":"Bioelectrical impedance parameters and nutritional status of pediatric patients with hematological malignancies: a cross-sectional study.","authors":"Alan E Guzmón-León, Katja Stein, Humberto Astiazaran-García, Mauro E Valencia, Trinidad Quizán-Plata, Verónica López-Teros","doi":"10.20960/nh.06868","DOIUrl":"https://doi.org/10.20960/nh.06868","url":null,"abstract":"<p><strong>Background: </strong>treatment of pediatric patients with hematologic malignancies (HM) affects their nutritional status and body composition. Bioelectrical impedance analysis (BIA) parameters [resistance (R), reactance (Xc), phase angle (PhA)] are non-invasive tools for assessing these changes. The objective was to compare standardized BIA parameters [R/height (h), Xc/h] and PhA of pediatric patients with HM against a healthy reference population.</p><p><strong>Methods: </strong>pediatric patients with HM (active treatment), anthropometric parameters [height, weight, mid-upper arm circumference (MUAC), waist circumference (WC), triceps skinfold thickness (TSF), handgrip strength (HGS)] and BIA parameters were measured before chemotherapy. Data were compared with an ethnically matched healthy reference population using t-tests and multivariate analysis of covariance (MANCOVA) with WC.</p><p><strong>Results: </strong>twenty-seven children (99 months) participated. Compared to the reference population, patients showed higher R/ht (+47.8 ohms/m, p = 0.020), lower Xc/ht (-26.2 ohms/m, p < 0.001), and PhA (-2.79°, p < 0.001). HGS was lower (-2.36 kg, p = 0.002), while WC (+9.38 cm, p < 0.001), TSF (+1.60 mm, p = 0.041), and arm fat area (+2.98 cm², p < 0.001) were higher. After adjusting for WC, the differences persisted (Pillai trace = 0.773, p < 0.001). PhA remained lower in patients (adjusted difference -2.78°, p < 0.001) and was independent of WC (p = 0.969).</p><p><strong>Conclusions: </strong>patients showed impaired cellular health (low PhA) and muscle function (low HGS) coexisting with increased adiposity (WC, TSF). The reduction in PhA was independent of WC, reinforcing its role as a specific marker of cellular deterioration. Direct BIA parameters, particularly PhA, offer a valuable non-invasive tool for the early identification of nutritional risk.</p>","PeriodicalId":19385,"journal":{"name":"Nutricion hospitalaria","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148813765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yang Luo, Siyi Qin, Hongyan Wang, Linfeng Liu, Xiangeng Zhang
{"title":"Associations of dietary diversity and specific food intake with abnormal sleep duration and sleep quality among older adults in China.","authors":"Yang Luo, Siyi Qin, Hongyan Wang, Linfeng Liu, Xiangeng Zhang","doi":"10.20960/nh.06891","DOIUrl":"https://doi.org/10.20960/nh.06891","url":null,"abstract":"<p><strong>Objective: </strong>to examine associations of dietary diversity and specific food intake with abnormal sleep duration (< 6 h or > 8 h) and sleep quality among older adults in China.</p><p><strong>Methods: </strong>this cross-sectional study used data from the 2018 Chinese Longitudinal Healthy Longevity Survey and included 12,760 adults aged ≥ 65 years. A simplified food frequency questionnaire was used to assess 15 food categories and calculate a dietary diversity score (0-15). Sleep duration was classified as normal (6-8 h) or abnormal (< 6 h or > 8 h), and sleep quality was self-rated on a five-point scale. Binary logistic regression was used for abnormal sleep duration and ordinal logistic regression for sleep quality, adjusting for sociodemographic, lifestyle, and health-related factors.</p><p><strong>Results: </strong>each 1-point increase in dietary diversity score was associated with lower odds of abnormal sleep duration (OR 0.935, 95 % CI 0.919-0.951) and higher odds of better sleep quality (OR 1.117, 95 % CI 1.100-1.135). Compared with Q4, Q1 was associated with lower odds of abnormal sleep duration (OR 0.659, 95 % CI 0.588-0.739) and higher odds of better sleep quality (OR 1.804, 95 % CI 1.633-1.994), with significant dose-response relationships (p for trend < 0.001). After false discovery rate correction, higher intake of fresh fruits and vegetables was associated with lower odds of abnormal sleep duration, while higher intake of fresh fruits, eggs, legumes, and nuts was associated with better sleep quality.</p><p><strong>Conclusions: </strong>higher dietary diversity was independently associated with lower odds of abnormal sleep duration and better sleep quality among older adults.</p>","PeriodicalId":19385,"journal":{"name":"Nutricion hospitalaria","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148813848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Gut microbiota and immunonutrition: a complementary perspective on the gut-skin axis].","authors":"Celaudys Cignoni","doi":"10.20960/nh.07043","DOIUrl":"https://doi.org/10.20960/nh.07043","url":null,"abstract":"","PeriodicalId":19385,"journal":{"name":"Nutricion hospitalaria","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148813783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ivonne Margarita Solís de la Cruz, Sandra Sabrina Rojo-Garza, Neri Alejandro Álvarez Villalobos, Gabriela Guadalupe Elizondo-Omaña, Alejandro Burciaga-Muñoz
{"title":"Dietary habits in children of parents with type 2 diabetes ‒ A cross-sectional parent-child analysis.","authors":"Ivonne Margarita Solís de la Cruz, Sandra Sabrina Rojo-Garza, Neri Alejandro Álvarez Villalobos, Gabriela Guadalupe Elizondo-Omaña, Alejandro Burciaga-Muñoz","doi":"10.20960/nh.06832","DOIUrl":"https://doi.org/10.20960/nh.06832","url":null,"abstract":"<p><strong>Introduction: </strong>evidence suggests that lifestyle habits are largely acquired within the family, where parents serve as behavioral role models. The presence of type 2 diabetes mellitus (T2D) in parents not only reflects a genetic predisposition but also indicates the coexistence of environmental and behavioral factors that increase metabolic risk within the household Objective: to evaluate dietary patterns in children with parents diagnosed with type 2 diabetes mellitus and to compare the dietary intake between parents and their children.</p><p><strong>Methods: </strong>a cross-sectional, analytic, observational study was performed in a primary care unit, including a total of 182 individuals: 77 parents with T2D and 105 children. Dietary intake was assessed using the Mexican Food Equivalents System, macronutrient intake was calculated using a 24-hour dietary recall.</p><p><strong>Results: </strong>no significant differences were observed in macronutrient intake. No participant met criteria for a healthy diet. Overall, 54.4 % were classified as having an unhealthy diet and 45.6 % as intermediate. Parents showed a higher proportion of unhealthy dietary patterns compared to children (67.5 % vs. 44.8 %, p = 0.002). Elevated consumption of sugar-sweetened beverages and low physical activity levels were observed in both groups.</p><p><strong>Conclusion: </strong>parents with T2D and their children exhibit predominantly inadequate dietary patterns. Although children showed slightly better dietary behavior than parents, diet quality remains poor in both groups. These findings highlight the necessity for family-based interventions targeting diet and lifestyle to reduce the intergenerational risk of metabolic diseases.</p>","PeriodicalId":19385,"journal":{"name":"Nutricion hospitalaria","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148813853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}