{"title":"Effects of probiotic supplementation on blood lipids ın hypercholesterolemic obese patients: a randomized, double-blind, placebo-controlled pilot trial.","authors":"Sibel Bulut, Seray Kabaran","doi":"10.20960/nh.05563","DOIUrl":"10.20960/nh.05563","url":null,"abstract":"<p><strong>Introduction: </strong>Objective: this trial aimed to determine the effects of probiotic supplementation on weight loss and lipid profiles in hypercholesterolemic obese patients. Methods: ın this pilot randomized, double-blind, placebo-controlled trial, hypercholesterolemic obese patients (BMI = 30.0-35.0 kg/m2) were randomly divided into 2 groups to receive either probiotic capsules (n = 12) or a matching placebo (n = 12) groups. The patients in the probiotic group took capsules 2 times a day that contained Enterococcus faecium, Lactobacillus plantarum, Streptococcus thermophiles, Bifidobacterium lactis, Lactobacillus acidophilus, Bifidobacterium longum (1.5 × 109 CFU/g) for 8 weeks. All patients adhered to a medical nutrition therapy that aimed for a weight loss of 0.5 to 1 kg per week. Anthropometric measurements and body composition were taken at baseline and were monitored every week throughout the study. Blood lipids were assessed at baseline and after the 8-week intervention. Results: after the 8-week dietary intervention, both probiotic and placebo groups showed significant decreased in total cholesterol (-36.50 ± 19.27 vs -25.91 ± 19.25, mg/dl), LDL-C (-(31.75 ± 18.11 vs -31.91 ± 31.00 mg/dl) and TG (-31.83 ± 67.37 vs -28.25 ± 59.09), respectively (p < 0.05). Body weight, BMI, body fat ratio, and waist circumference also significantly decreased after the dietary intervention in both groups (p < 0.05). Overall, no significant difference was found neither in the reductions of total cholesterol, LDL-C, TG concentrations nor the anthropometric indices between the probiotic and placebo groups (p > 0.05). Conclusions: the results of our study demonstrated that the administration of probiotic supplements for 8 weeks in obese subjects with hypercholesterolemia had favorable effects on lipid profiles, although there was no beneficial effect compared to the control group. These results indicate that anthropometric indices significantly decreased in response to adherence to the low-calorie diet recommended by dietitians in both the groups. However, conducting more trails with large sample size and longer follow-up time is necessary.</p>","PeriodicalId":19385,"journal":{"name":"Nutricion hospitalaria","volume":" ","pages":"253-264"},"PeriodicalIF":2.5,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Urea in chronic syndrome of inappropriate antidiuretic hormone secretion: dietary supplement or drug].","authors":"Emilia Gómez Hoyos, Daniel de Luis Román","doi":"10.20960/nh.05863","DOIUrl":"10.20960/nh.05863","url":null,"abstract":"<p><strong>Introduction: </strong></p>","PeriodicalId":19385,"journal":{"name":"Nutricion hospitalaria","volume":" ","pages":"199-200"},"PeriodicalIF":2.5,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[The importance of core outcome sets in clinical research: a call to action].","authors":"Joaquín González Aroca","doi":"10.20960/nh.05499","DOIUrl":"10.20960/nh.05499","url":null,"abstract":"<p><strong>Introduction: </strong></p>","PeriodicalId":19385,"journal":{"name":"Nutricion hospitalaria","volume":" ","pages":"190-191"},"PeriodicalIF":2.5,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142471152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Foods fortified with vitamin D. Mith or reality?","authors":"Teodoro Durá-Travé","doi":"10.20960/nh.05580","DOIUrl":"10.20960/nh.05580","url":null,"abstract":"<p><strong>Introduction: </strong></p>","PeriodicalId":19385,"journal":{"name":"Nutricion hospitalaria","volume":" ","pages":"389-390"},"PeriodicalIF":2.5,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Legislative clarifications on the article \"2024 Positioning of the SEEDO Dietary Guidelines\"].","authors":"Antoni García Gabarra","doi":"10.20960/nh.05848","DOIUrl":"10.20960/nh.05848","url":null,"abstract":"<p><strong>Introduction: </strong></p>","PeriodicalId":19385,"journal":{"name":"Nutricion hospitalaria","volume":" ","pages":"398-399"},"PeriodicalIF":2.5,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Consumption of ultra-processed foods raises the possibility of cardiovascular disease - A meta-analysis.","authors":"Jiaxin You, Jinjie Hou, Xiaoran Xie, Rong Xu","doi":"10.20960/nh.05325","DOIUrl":"10.20960/nh.05325","url":null,"abstract":"<p><strong>Introduction: </strong>Aim: the purpose of this study was to assess the connection among ultra-processed food consumption and the likelihood of cardiovascular disease, with the intention of establishing a basis for future research. Methods: this meta-analysis adheres to the reporting principles recommended in the PRISMA framework. PubMed, Embase, and Web of Science bibliographic databases were searched in January 2023. Results: ten observational studies were identified from 1,079 records retrieved by searching various relevant electronic bibliographic databases, and two additional observational studies were identified from references within one of the retrieved records; leading to the inclusion of a total of twelve observational studies. The data were combined, utilizing random effects models as well as relative risk ratios. Consuming a higher quantity of ultra-processed foods was found to be correlated with a 31 % elevated likelihood of mortality due to cardiovascular disease, in comparison to individuals who abstained from consuming any ultra-processed foods. Furthermore, an association has been seen between increased consumption of ultra-processed food and an elevated likelihood of acquiring hypertension, coronary heart disease, and cerebrovascular disorders. Conclusion: consuming a significant quantity of ultra-processed meals increases the likelihood of developing cardiovascular disease or experiencing mortality associated with cardiovascular disease.</p>","PeriodicalId":19385,"journal":{"name":"Nutricion hospitalaria","volume":" ","pages":"117-130"},"PeriodicalIF":2.5,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142687757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Predictive values of body mass index, prognostic nutritional index and C-reactive protein to prealbumin ratio for prognosis of patients receiving radical gastrectomy.","authors":"Yijie Yang, Jiale Yang, Lu Xu","doi":"10.20960/nh.05445","DOIUrl":"10.20960/nh.05445","url":null,"abstract":"<p><strong>Introduction: </strong>Introduction: we aimed to analyze the predictive values of body mass index (BMI), prognostic nutritional index (PNI) and C-reactive protein to prealbumin ratio (CRP/PA) for the prognosis of patients receiving radical gastrectomy. Materials and methods: one hundred patients subjected to radical gastrectomy from August 2015 to January 2018 were enrolled. The cut-off values of BMI, PNI and CRP/PA on the receiver operating characteristic (ROC) curves were obtained and applied to establish a low BMI group (n = 46) and a high BMI group (n = 54), a low PNI group (n = 48) and a high PNI group (n = 52), as well as a low CRP/PA group (n = 57) and a high CRP/PA group (n = 43). Results and conclusion: through comparing the low BMI group with the high BMI group, there were differences in the tumor diameter, invasion depth, clinical stage, and lymph node metastasis status (p < 0.05). Differences were found in the invasion depth, tumor diameter, lymph node metastasis status, clinical stage, and postoperative adjuvant therapy in the low CRP/PA group compared with the high CRP/PA group (p < 0.05). The survival rate of all patients was 45 % (45/100) during the 5 years of follow-up. According to the Kaplan-Meier survival analysis, the low BMI group, low PNI group and high CRP/PA group had significantly reduced overall survival rates in comparison to those of the high BMI group, high PNI group and low CRP/PA group, respectively (p < 0.05). BMI, PNI and CRP/PA have important predictive values for the prognosis of patients undergoing radical gastrectomy.</p>","PeriodicalId":19385,"journal":{"name":"Nutricion hospitalaria","volume":" ","pages":"275-284"},"PeriodicalIF":2.5,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Qi Liu, Yi Zheng, Kunpeng Wang, Jihong Zhong, Xiao Yu
{"title":"Advancements in the application of semi-solidified feeding in enteral nutrition for critically-ill patients: a comprehensive review.","authors":"Qi Liu, Yi Zheng, Kunpeng Wang, Jihong Zhong, Xiao Yu","doi":"10.20960/nh.05399","DOIUrl":"10.20960/nh.05399","url":null,"abstract":"<p><strong>Introduction: </strong>Enteral nutrition represents the primary modality of nutritional support for critically ill patients. However, challenges such as gastroesophageal reflux, diarrhea, and abdominal distension often manifest during its administration. Enteral nutrition semi-solidified feeding has emerged as a promising alternative, demonstrating notable efficacy. This study systematically explores the literature on semi-solidified enteral nutrition, discussing its conceptual framework, classifications, relative merits, and drawbacks compared to traditional enteral nutrition. Additionally, it illustrates clinical application and associated complications, offering valuable insights for the implementation of semi-solidified enteral nutrition in critically ill patients.</p>","PeriodicalId":19385,"journal":{"name":"Nutricion hospitalaria","volume":" ","pages":"145-152"},"PeriodicalIF":2.5,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Isabel Gómez-Ibáñez, Laura Gratacós-Santanach, Ana Pérez-Plasencia, Sonsoles García-Rodicio, Neus Sunyer-Esquerrà, Yaiza Ortuño-Ruiz, Carles Quiñones-Ribas
{"title":"[Valproic acid and protein supplements: possible clinically relevant drug interaction].","authors":"Isabel Gómez-Ibáñez, Laura Gratacós-Santanach, Ana Pérez-Plasencia, Sonsoles García-Rodicio, Neus Sunyer-Esquerrà, Yaiza Ortuño-Ruiz, Carles Quiñones-Ribas","doi":"10.20960/nh.05371","DOIUrl":"10.20960/nh.05371","url":null,"abstract":"<p><strong>Introduction: </strong>Introduction: valproic acid (VPA) is a drug with narrow therapeutic index (50-100 µg/mL) with a high pharmacokinetic variability due to plasma protein binding saturation (PPBU). Case report: we present a clinical case of a 60-year-old patient under treatment with VPA, whose plasma VPA concentrations were analyzed and a decrease in these concentrations was detected when administrated with protein supplement. When the intake was spaced out, VPA serum concentrations returned to the therapeutic range. Discussion: administration with food does not appear to be important according to the majority of the literature available to date. However, this case seems to show that protein supplements can interact with VPA and it is important to space out the intake between them to minimize variation in plasma concentrations.</p>","PeriodicalId":19385,"journal":{"name":"Nutricion hospitalaria","volume":" ","pages":"184-187"},"PeriodicalIF":2.5,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}