Shupeng Chen, Meiling Zhang, Yao Gao, Yingjian Zeng
{"title":"Causal effects of vitamin D on leukemia risk: insights from two-sample Mendelian randomization analysis.","authors":"Shupeng Chen, Meiling Zhang, Yao Gao, Yingjian Zeng","doi":"10.20960/nh.05541","DOIUrl":"https://doi.org/10.20960/nh.05541","url":null,"abstract":"<p><strong>Background: </strong>vitamin D plays a crucial role in immune regulation, anti-inflammatory processes, and tumor suppression, but its relationship with leukemia risk remains unclear. This study aims to evaluate the causal relationship between vitamin D levels and the risk of different types of leukemia through a two-sample Mendelian randomization (MR) analysis.</p><p><strong>Methods: </strong>data from large-scale genome-wide association studies (GWAS) were used, and genetic variants associated with vitamin D were selected as instrumental variables. The relationship between vitamin D levels and the risk of acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), chronic lymphocytic leukemia (CLL), and chronic myeloid leukemia (CML) was examined. The inverse variance weighted (IVW) method was applied as the primary analytical approach. Heterogeneity was assessed through Cochran's Q test, pleiotropy was evaluated using the MR-Egger intercept, and sensitivity analyses were performed to ensure the robustness of the results.</p><p><strong>Results: </strong>MR analysis showed a significant inverse association between serum 25-hydroxyvitamin D levels and the risk of CML (OR = 0.44, 95 % CI: 0.25-0.78, p = 0.005), suggesting a potential protective effect of vitamin D against CML. No significant causal relationships were found between vitamin D levels and the risks of AML, ALL, or CLL. Sensitivity analyses supported the robustness of these findings, with no evidence of heterogeneity or pleiotropy.</p><p><strong>Conclusion: </strong>the findings indicate that higher vitamin D levels may reduce the risk of CML, while the effects on other types of leukemia require further investigation. The potential role of vitamin D in leukemia prevention warrants more mechanistic studies and clinical validation.</p>","PeriodicalId":19385,"journal":{"name":"Nutricion hospitalaria","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Response to the Letter to the Editor: \"The importance of social determinants in the detection of depressive symptoms and their relationship to tap water consumption\"].","authors":"María-Reyes Pérez-Fernández, María-Milagros Fernández-Varela, Natalia Fariñas-Valiña, Juan-Imeldo Rodríguez-Garrido, Miriam Vázquez-Campo","doi":"10.20960/nh.05555","DOIUrl":"https://doi.org/10.20960/nh.05555","url":null,"abstract":"","PeriodicalId":19385,"journal":{"name":"Nutricion hospitalaria","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aria Aulia Nastiti, Mira Triharini, Nofinda Widya Sari, Ni Ketut Alit Armini, Nursalam Nursalam, Sandeep Poddar
{"title":"Nutritional fulfillment behavior of pregnant women based on the health belief model theory in Indonesia.","authors":"Aria Aulia Nastiti, Mira Triharini, Nofinda Widya Sari, Ni Ketut Alit Armini, Nursalam Nursalam, Sandeep Poddar","doi":"10.20960/nh.05022","DOIUrl":"https://doi.org/10.20960/nh.05022","url":null,"abstract":"<p><strong>Introduction: </strong>malnutrition in pregnant women will cause impaired fetal development, premature delivery, impaired baby growth, and the risk of causing chronic disease. The Health Belief Model is used and has an important role in directing pregnant women to engage in preventive health behavior, namely preventing malnutrition.</p><p><strong>Objective: </strong>this study aims to analyze the factors related to the nutritional fulfillment behavior of pregnant women based on the theory of the health belief model.</p><p><strong>Methods: </strong>this research used correlational design with a cross-sectional approach. The total sample is 164 pregnant women. The variables were perceived susceptibility, perceived severity, perceived benefits, perceived barriers, cues to action, self-efficacy, and behavior of fulfilling the nutritional needs. Data were collected using a questionnaire and analyzed using Spearman's rho with a p-value ≤ 0.05.</p><p><strong>Result: </strong>factors related to the behavior of fulfilling nutritional needs of pregnant women are, perceived benefits (p = 0.021), perceived barriers (p = 0.034) and cues to action (p = 0.032). Meanwhile, perceived susceptibility, perceived severity, and self-efficacy do not correlate with the nutritional fulfillment behavior of pregnant women.</p><p><strong>Conclusion: </strong>factors related to the behavior of fulfilling nutritional needs are perceived benefits, perceived barriers, and cues to action. Future research is expected to develop a health belief model factor for intervention to improve behavior in fulfilling nutritional needs in pregnant women.</p>","PeriodicalId":19385,"journal":{"name":"Nutricion hospitalaria","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Verónica Martínez Lara, José Alberto Ramírez de León, Dionicio Morales Ramírez, Brian González Pérez
{"title":"[Design and validation of an instrument to measure healthy habits and emotional state in adolescents].","authors":"Verónica Martínez Lara, José Alberto Ramírez de León, Dionicio Morales Ramírez, Brian González Pérez","doi":"10.20960/nh.05470","DOIUrl":"https://doi.org/10.20960/nh.05470","url":null,"abstract":"<p><strong>Introduction: </strong>obesity is a condition that increases the risk of presenting other non-communicable diseases, reducing life expectancy and quality of life in individuals. Its development involves a complex interaction of several factors, the main ones being inadequate food intake and lack of physical activity.</p><p><strong>Objective: </strong>to design and validate a tool to identify eating habits, physical activity and emotional state in adolescents.</p><p><strong>Methods: </strong>an observational study was carried out in 2 instances design and validation, using the Delphi method, taking as a basis for its design the 7 stages proposed by Sampieri. The design, based on the systematic review of the literature, was proposed by the coordinating group. Validation was carried out in 2 phases: the first by means of the criteria of judges, with the participation of 17 experts who evaluated the wording and relevance of each item, and the second by means of statistical analysis estimating the Aiken V coefficient, binomial tests, Cronbach's Alpha and McDonald's Omega. It was applied to a sample of 673 adolescents from the southern area of the state of Tamaulipas, Mexico.</p><p><strong>Results: </strong>an instrument composed of 46 items in 3 dimensions was obtained. In the validation, binomial tests were estimated, showing a significance of 0.000, which indicates that the questions are correlated. Likewise, the Aiken V coefficient was estimated for all the items, which presented a value > 0.7, establishing adequate content validity for each one of them. Finally, the reliability tests estimated by means of Cronbach's Alpha and McDonald's Omega obtained an overall value of 0.777, which indicates that the instrument is reproducible and consistent.</p><p><strong>Conclusions: </strong>the tool generated presented validity and reliability indicating that it is suitable for its application in the assessment of risk in healthy habits of adolescents (diet and physical activity) and of alteration in their emotional state.</p>","PeriodicalId":19385,"journal":{"name":"Nutricion hospitalaria","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Maternal perception of hunger-satiety signals and their impact on feeding and nutritional status of infants in Mexico].","authors":"Rosario Edith Ortiz Félix, Patricia Enedina Miranda Félix, Félix Gerardo Buichia Sombra, Liliana Estefanía Ramírez-Jaime, Milton Carlos Guevara Valtier, Velia Margarita Cárdenas-Villarreal","doi":"10.20960/nh.05438","DOIUrl":"https://doi.org/10.20960/nh.05438","url":null,"abstract":"<p><strong>Introduction: </strong>nutrition during the first two years of life is crucial for the physical, cognitive, and emotional development of children. This study aimed to: 1) associate maternal perception of hunger and satiety signals with the type of feeding; 2) associate maternal perception of hunger and satiety signals with the infant's weight status; and 3) determine the influence of feeding type on the infant's BMI-for-age.</p><p><strong>Methods: </strong>a descriptive correlational cross-sectional study was conducted with 424 mother-infant dyads in Sinaloa, Mexico, using systematic random sampling. Mothers completed questionnaires on feeding practices and perception of hunger and satiety signals. Anthropometric data of the infant were measured, and the influence of feeding type on the infant's BMI-for-age z-score was analyzed using multiple linear regression.</p><p><strong>Results: </strong>45.8 % of mothers reported a low perception of hunger and satiety signals. 30.2 % of infants were overweight. Mothers with a high perception of signals reported a lower proportion of overweight infants. Mixed feeding and early introduction of complementary foods significantly influence the increase in infant zIMC/age score.</p><p><strong>Conclusions: </strong>maternal perception of hunger and satiety signals influences the infant's weight status. Mixed feeding and early introduction of complementary foods increase the risk of overweight in infants. It is crucial to promote adequate perception of these signals to prevent nutritional problems in early childhood.</p>","PeriodicalId":19385,"journal":{"name":"Nutricion hospitalaria","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142687765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
José de Jesús Vargas Lares, Lisset Del Carmen López Segovia, Jonathan Antonio Casillas Moreno, Juan Carlos Barrera de León
{"title":"[Nutritional risk assessment by STAMP according to type of congenital heart disease in pediatric patients admitted to a reference hospital].","authors":"José de Jesús Vargas Lares, Lisset Del Carmen López Segovia, Jonathan Antonio Casillas Moreno, Juan Carlos Barrera de León","doi":"10.20960/nh.05421","DOIUrl":"https://doi.org/10.20960/nh.05421","url":null,"abstract":"<p><strong>Introduction: </strong>patients with congenital heart disease are considered to be at high nutritional risk due to alterations in the metabolism of the underlying pathology and extracardiac factors. The STAMP (Screening Tool for the Assessment of Malnutrition in Paediatrics) is the only tool validated in our country in a pediatric population for nutritional screening.</p><p><strong>Objective: </strong>to evaluate nutritional risk by STAMP screening in pediatric patients according to type of congenital heart disease.</p><p><strong>Material and methods: </strong>an analytical cross-sectional study in 2023 in a pediatric reference hospital. Nutritional status was determined by Z scores based on WHO 2006/CDC 2000 child growth standards. The STAMP questionnaire was administered to establish nutritional risk. Inferential statistics with the Chi-squared and Mann-Whitney U-test were used. Spearman's correlation coefficient was used. Analyses were carried out using the SPSS V25 statistical package.</p><p><strong>Results: </strong>113 patients were included, male (n = 57, 50.4 %) and female (n = 56, 49.6 %). The most common age group was that of infants (n = 47, 45 %). Acute or chronic nutritional status impairment affected n = 50 (44.3 %) subjects. Cyanogenous congenital heart diseases had a greater impact on weight, height, average arm circumference and height/age, WBC/age indices. Two nutritional risk groups were established by STAMP: intermediate risk, n = 74 (65.5 %), and high risk, n = 39 (34.5 %). The greatest impact on anthropometric parameters was associated with elevated risk by STAMP, p = 0.000. The type of congenital heart disease was not associated with a greater increase in nutritional risk by STAMP (p = 0.76). There was no correlation of STAMP score with biochemical parameters.</p><p><strong>Conclusion: </strong>patients with congenital heart disease will have an intermediate risk per STAMP. The type of congenital heart disease is not related to a greater increase in nutritional risk due to STAMP.</p>","PeriodicalId":19385,"journal":{"name":"Nutricion hospitalaria","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142687771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Influence of nutritional risk assessment on the prognosis of trauma patients.","authors":"Fei Li, Haiyang Guan, Ying Liu","doi":"10.20960/nh.05464","DOIUrl":"https://doi.org/10.20960/nh.05464","url":null,"abstract":"<p><strong>Background: </strong>malnutrition negatively impacts trauma prognosis, and this study aimed to evaluate the NRI as a prognostic factor alongside other variables such as comorbidities and the Barthel Index (BI).</p><p><strong>Objective: </strong>to evaluate the NRI as a prognostic factor while considering other variables, including nutritional parameters, comorbidities, and the Barthel Index. Although mortality was the primary outcome, we will clarify this to avoid any confusion.</p><p><strong>Methods: </strong>a cohort of 80 Chinese trauma patients, aged 30-69 years, was analyzed through prospective data collection at admission and post-discharge, covering mortality, nutritional factors, and prognostic indicators. The average observation period was 5.83 months, with an average admission age of 45.6 years.</p><p><strong>Results: </strong>this study examined the relationship between nutritional parameters, trauma, and their effects on mortality and survival. The 6-month survival rate was 93 %, and a correlation was noted between mortality risk and patients with Nutritional Risk Index (NRI) scores greater than 96. However, those with severe risk (NRI < 83.5) did not show a significant association with mortality, possibly due to a small sample size (n = 4), suggesting the need for larger studies to further explore this relationship. The Cox proportional hazard analysis identified older age, lower NRI scores, and specific comorbidities like ischemic heart disease, chronic kidney disease, and hypertension as significant mortality risk factors. Additionally, types of fractures, particularly radius and ulna and vertebral fractures, were linked to higher mortality. Lower Barthel Index scores at admission and discharge were significant predictors of mortality; however, deceased patients often had higher BI scores, indicating that a low BI cannot be universally regarded as a risk factor.</p><p><strong>Conclusion: </strong>overall, the findings emphasize that older age, lower NRI scores, and comorbidities are critical predictors of mortality in trauma patients, while the relationship between the Barthel Index and outcomes requires further clarification.</p>","PeriodicalId":19385,"journal":{"name":"Nutricion hospitalaria","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142687773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Consumption of ultra-processed foods raises the possibility of cardiovascular disease - A meta-analysis.","authors":"Jiaxin You, Jinjie Hou, Xiaoran Xie, Rong Xu","doi":"10.20960/nh.05325","DOIUrl":"https://doi.org/10.20960/nh.05325","url":null,"abstract":"<p><strong>Aim: </strong>the purpose of this study was to assess the connection among ultra-processed food consumption and the likelihood of cardiovascular disease, with the intention of establishing a basis for future research.</p><p><strong>Methods: </strong>this meta-analysis adheres to the reporting principles recommended in the PRISMA framework. PubMed, Embase, and Web of Science bibliographic databases were searched in January 2023.</p><p><strong>Results: </strong>ten observational studies were identified from 1,079 records retrieved by searching various relevant electronic bibliographic databases, and two additional observational studies were identified from references within one of the retrieved records; leading to the inclusion of a total of twelve observational studies. The data were combined, utilizing random effects models as well as relative risk ratios. Consuming a higher quantity of ultra-processed foods was found to be correlated with a 31 % elevated likelihood of mortality due to cardiovascular disease, in comparison to individuals who abstained from consuming any ultra-processed foods. Furthermore, an association has been seen between increased consumption of ultra-processed food and an elevated likelihood of acquiring hypertension, coronary heart disease, and cerebrovascular disorders.</p><p><strong>Conclusion: </strong>consuming a significant quantity of ultra-processed meals increases the likelihood of developing cardiovascular disease or experiencing mortality associated with cardiovascular disease.</p>","PeriodicalId":19385,"journal":{"name":"Nutricion hospitalaria","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142687757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Association between body mass index, muscle-to-fat ratio, and handgrip strength-to-BMI ratio with physical fitness in children from North Macedonia.","authors":"Arijana Llagjeviq-Govori, Seryozha Gontarev, Agon Saiti, Slavica Novacevska, Jana Karsakovska Dimitrievska, Vlatko Nedelkovski","doi":"10.20960/nh.05417","DOIUrl":"https://doi.org/10.20960/nh.05417","url":null,"abstract":"<p><strong>Background: </strong>this cross-sectional study, conducted on a convenience sample of 2197 Macedonian primary school children, aimed to examine how certain anthropometric indices (body mass index (BMI), muscle-fat ratio (MFR), hand grip strength-BMI ratio) are related to the physical fitness of individuals.</p><p><strong>Methods: </strong>the sample was split into two groups based on gender: 1096 boys and 1101 girls (average age 8.1 ± 1.3 years). Data on anthropometric measurements (BMI, MFR) were taken and the physical fitness was measured with the following tests: sit and reach, handgrip strength, standing long jump, sit-ups 30 sec., shuttle run 4 x 10 m, and 20 meters shuttle-run test (20-mSRT).</p><p><strong>Results: </strong>the findings from the study indicate that children with normal weight exhibit superior levels of cardiorespiratory, muscular, and motor fitness in comparison to those who are categorized as obese, irrespective of gender. Both muscle‑to‑fat ratio (MFR), and grip strength-to-BMI ratio showed correlation with most fitness tests. Grip strength-to-BMI ratio showed a positive correlation with the results of the handgrip test in boys and girls.</p><p><strong>Conclusion: </strong>in this population, BMI, MFR, and handgrip strength-to-BMI ratio can serve as indicators of health and physical fitness.</p>","PeriodicalId":19385,"journal":{"name":"Nutricion hospitalaria","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142605383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fabio Ued, Murilo Jose Silveira Castro, Laura Ruy Bardi, Luiz Del Ciampo, Edson Zangiacomi Martinez, Ivan Savioli Ferraz, Andrea Aparecida Contini, Elza Mello, Carlos Alberto Nogueira-de-Almeida
{"title":"Triponderal Mass Index rather than Body Mass Index in discriminating high adiposity in Brazilian children and adolescents.","authors":"Fabio Ued, Murilo Jose Silveira Castro, Laura Ruy Bardi, Luiz Del Ciampo, Edson Zangiacomi Martinez, Ivan Savioli Ferraz, Andrea Aparecida Contini, Elza Mello, Carlos Alberto Nogueira-de-Almeida","doi":"10.20960/nh.05432","DOIUrl":"https://doi.org/10.20960/nh.05432","url":null,"abstract":"<p><strong>Introduction: </strong>body mass index (BMI) is used worldwide to track excess weight; however, it has limitations in predicting body fat percentage (BF%). Triponderal mass index (TMI) has been studied as an alternative indicator to predict BF%.</p><p><strong>Objective: </strong>to compare BMI and TMI as predictors of BF% and develop TMI cutoff points for screening high adiposity in Brazilian children and adolescentes.</p><p><strong>Methods: </strong>a cross-sectional and multicenter study conducted with 226 individuals aged 5 to 17 years from two municipalities in the Southeast and South regions of Brazil. BF% was assessed by bioimpedancemetry. The association between BMI and TMI with BF% was assessed using generalized additive models. ROC curve analyzes were performed to verify the accuracy of BMI and TMI in detecting high adiposity. The areas under the curve (AUC) of BMI and TMI were compared using non-parametric analysis. The TMI cutoff points were obtained using Youden's J index.</p><p><strong>Results: </strong>bioimpedancemetry detected high BF% in 54.1 % (95 % confidence interval [CI], 44.8-63.2) of boys and 63.5 % (95 % CI, 54.5-71.9) of girls. TMI was able to predict BF% better than BMI in males, presenting a higher R-square (0.737 versus 0.646, respectively). The TMI presented AUC significantly greater than BMI to indicate high adiposity in the entire population (p = 0.007) and in females (p = 0.014). TMI cutoff points for different age groups and sex were presented.</p><p><strong>Conclusion: </strong>TMI proved to be a better predictor of excess body fat than BMI in Brazilian children and adolescents.</p>","PeriodicalId":19385,"journal":{"name":"Nutricion hospitalaria","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142605398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}