Isabel Gómez-Ibáñez, Laura Gratacós-Santanach, Ana Pérez-Plasencia, Sonsoles García-Rodicio, Neus Sunyer-Esquerrà, Yaiza Ortuño-Ruiz, Carles Quiñones-Ribas
{"title":"[Valproic acid and protein supplements: possible clinically relevant drug interaction].","authors":"Isabel Gómez-Ibáñez, Laura Gratacós-Santanach, Ana Pérez-Plasencia, Sonsoles García-Rodicio, Neus Sunyer-Esquerrà, Yaiza Ortuño-Ruiz, Carles Quiñones-Ribas","doi":"10.20960/nh.05371","DOIUrl":"10.20960/nh.05371","url":null,"abstract":"<p><strong>Introduction: </strong>Introduction: valproic acid (VPA) is a drug with narrow therapeutic index (50-100 µg/mL) with a high pharmacokinetic variability due to plasma protein binding saturation (PPBU). Case report: we present a clinical case of a 60-year-old patient under treatment with VPA, whose plasma VPA concentrations were analyzed and a decrease in these concentrations was detected when administrated with protein supplement. When the intake was spaced out, VPA serum concentrations returned to the therapeutic range. Discussion: administration with food does not appear to be important according to the majority of the literature available to date. However, this case seems to show that protein supplements can interact with VPA and it is important to space out the intake between them to minimize variation in plasma concentrations.</p>","PeriodicalId":19385,"journal":{"name":"Nutricion hospitalaria","volume":" ","pages":"184-187"},"PeriodicalIF":2.5,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
David Fernando López-Daza, Ricardo Merchán-Chaverra, Yeny Cuéllar-Fernández, María Camila Gómez-Univio, Daniela Beatriz Ardila-Mendoza, María Cristina Posada-Álvarez, Patricia Savino-Lloreda
{"title":"[WHO guidance on non-nutritive sweeteners - A critical analysis].","authors":"David Fernando López-Daza, Ricardo Merchán-Chaverra, Yeny Cuéllar-Fernández, María Camila Gómez-Univio, Daniela Beatriz Ardila-Mendoza, María Cristina Posada-Álvarez, Patricia Savino-Lloreda","doi":"10.20960/nh.05728","DOIUrl":"10.20960/nh.05728","url":null,"abstract":"<p><strong>Introduction: </strong>The use of non-sugar sweeteners (NSS) has gained prominence as an alternative to reduce free sugar consumption, aligning with global efforts to combat the growing prevalence of non-communicable diseases (NCDs). By providing sweetness without caloric energy, NSS are viewed as potential tools in addressing diet-related health challenges. However, their long-term effects on health remain contentious, especially within the medical community. In 2023, the World Health Organization (WHO) released guidelines evaluating the role of NSS in promoting healthy eating, preventing weight gain, and mitigating NCDs. While some studies highlight benefits, such as lower body weight and reduced energy intake, the evidence is inconclusive. Observational research predominantly raises concerns about potential risks associated with NSS, but these studies face limitations, including biases and confounding variables that hinder causal conclusions. This analysis underscores the urgent need for comprehensive, high-quality research to clarify the risks and benefits of NSS. Current evidence is limited in scope and fails to address critical knowledge gaps, particularly regarding their long-term implications for the general population and individuals with NCDs. Expanding the scientific understanding of NSS is essential to inform public health recommendations and clinical guidelines effectively.</p>","PeriodicalId":19385,"journal":{"name":"Nutricion hospitalaria","volume":" ","pages":"376-384"},"PeriodicalIF":2.5,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Assessment of mindfulness in addressing emotional eating and perceived stress among children aged 9-11 years.","authors":"Hilal Doğan Güney, Pınar Göbel","doi":"10.20960/nh.05222","DOIUrl":"10.20960/nh.05222","url":null,"abstract":"<p><strong>Introduction: </strong>Introduction: there is a paucity of studies in the literature examining the relationship between children, mindfulness and diet. In this context, this study was designed to assess emotional eating and perceived stressful situations with mindfulness in children. Methods: this study was conducted with the participation of 349 children (128 boys, 221 girls) aged 9-11 living in the Karabük province. The study collected data on the participants' sociodemographic information, anthropometric measurements, number of main meals and snacks consumed per day, meal-skipping status, reasons for skipping meals, dietary motivations, and their scores on the Mindfulness Scale for Children (BAU-MSC), the Emotional Eating Scale for Children and Adolescents (EES-C), and the Perceived Stress Scale in Children (8-11 years) (PSS-C). Results: 58.17 % of the participants had 2 main meals, 30.2 % had 3 or more main meals; 37.5 % consumed 1 snack, 31.5 % consumed 2 snacks. A positive, weakly statistically significant relationship was detected between age and body weight and height. A positive, weakly statistically significant relationship was detected between age and EES-C, anxiety-anger-disappointment subscales and PSS-C scores (r = 0.161; r = 0.178; r = 0.250; p = 0.003; p = 0.001; p = 0.000). Conclusion: future studies with larger samples are needed to better understand the relationship between mindfulness and emotional eating and perceived stress situations in children.</p>","PeriodicalId":19385,"journal":{"name":"Nutricion hospitalaria","volume":" ","pages":"10-18"},"PeriodicalIF":2.5,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mariela Vega-Cárdenas, Maribel Barragán, Margarita Terán-García, Juan Manuel Vargas-Morales, Diana Patricia Portales-Pérez, Celia Aradillas-García
{"title":"Association between Dietary Inflammatory Index and IL-17A level in a Mexican cross-sectional study.","authors":"Mariela Vega-Cárdenas, Maribel Barragán, Margarita Terán-García, Juan Manuel Vargas-Morales, Diana Patricia Portales-Pérez, Celia Aradillas-García","doi":"10.20960/nh.05344","DOIUrl":"10.20960/nh.05344","url":null,"abstract":"<p><strong>Introduction: </strong>Introduction: the Dietary Inflammatory Index (DII) provides a quantitative means for assessing the role of diet in relation to health outcomes. Objetive: this study aimed to assess the association between the inflammatory potential of diet, as measured by the DII and IL-17A levels in young adults. Methods: a cross-sectional study was conducted on 69 adults between 18-30 y of age in San Luis Potosi, Mexico. Fasting blood samples were collected to analyze lipid profile, glucose homeostasis, and IL-17A. Dietary intake was assessed using a 24-hour recall. DII scores were calculated from 19 available food parameters. Univariate linear regression models were estimated to evaluate the possible dependence of IL-17A levels (dependent variables) on some potential explicative variables such as anthropometric, clinical, biochemical, and dietary variables. Results: there was a high inflammatory potential, with a mean DII score of +1.04 (range: -2.19 to +2.78). The DII was not associated with BMI, IL-17A levels or cardiometabolic risk factors. Conclusion: the study shows that the diets of healthy college-aged Mexican adults had a high inflammatory potential.</p>","PeriodicalId":19385,"journal":{"name":"Nutricion hospitalaria","volume":" ","pages":"243-252"},"PeriodicalIF":2.5,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143503055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chunlei Li, Yajun Chen, Hongmei Wu, Yaqi Zeng, Yueying Li, Jie Dong, Yujie Wang, Tianqiang Song
{"title":"Influence of handgrip strength on postoperative complications and survival in primary liver cancer patients.","authors":"Chunlei Li, Yajun Chen, Hongmei Wu, Yaqi Zeng, Yueying Li, Jie Dong, Yujie Wang, Tianqiang Song","doi":"10.20960/nh.05564","DOIUrl":"10.20960/nh.05564","url":null,"abstract":"<p><strong>Introduction: </strong>Objectives: the impact of handgrip strength (HGS) on postoperative complications and long-term survival following hepatectomy in patients with primary liver cancer (PLC) remains unclear. This study aimed to evaluate the influence of HGS on postoperative complications and overall survival in patients with PLC. Methods: in total, 298 patients with PLC who underwent liver resection were included in the prospective cohort study. Baseline, surgical, and histopathological factors were analyzed using univariate and multivariate analyses to identify risk factors for postoperative complications and mortality. Results: the incidence of major postoperative complications was 40.3 % and 24.6 % in the low and high HGS groups, respectively. During the median follow-up period of 28.8 months, 57 patients (19.1 %) died. patients with low HGS demonstrated a significantly shorter median overall survival compared to those with high HGS (p < 0.001). Short-term analysis revealed that low HGS (p = 0.022) and intraoperative blood loss (≥ 200 ml) (p < 0.001) were independently associated with postoperative complications. Furthermore, low HGS was identified as an independent predictor of poor overall survival in long-term survival analysis (p = 0.005). Conclusions: preoperative HGS emerged as an independent factor for postoperative complications and a prognostic indicator of poor long-term outcomes in patients with PLC.</p>","PeriodicalId":19385,"journal":{"name":"Nutricion hospitalaria","volume":" ","pages":"302-310"},"PeriodicalIF":2.5,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Intermittent fasting for glycemic control in patients with type 2 diabetes: a meta-analysis of randomized controlled trials.","authors":"Xiaoyi Huang, Guihao Huang, Guiju Wei","doi":"10.20960/nh.05521","DOIUrl":"10.20960/nh.05521","url":null,"abstract":"<p><strong>Introduction: </strong>Objective: to systematically evaluate the efficacy and safety of Intermittent Fasting (IF) in patients with type 2 diabetes (T2DM). Method: randomized controlled trials (RCTs) on the efficacy of IF intervention in T2DM were systematically searched from PubMed, The Cochrane Library, Web of Science, MEDLINE and CNKI, and retrieval time was set from database onset to September 2024. A meta-analysis was performed using the RevMan 5.3 software. Results: sixteen articles were included, with a total of 5369 patients. The meta-analysis showed that, compared with the control group, IF could improve patients' glycated hemoglobin, fasting plasma glucose, body weight, BMI, waist circumference, systolic blood pressure, diastolic blood pressure, low density lipoprotein, and cholesterol levels (p < 0.05). However, there was no significant difference in improving the levels of postprandial plasma glucose, high-density lipoprotein, and triglyceride levels compared to the control group (p > 0.05). Conclusion: IF may help people with T2DM manage their blood sugar levels effectively. In addition, IF can reduce body weight, reduce waist circumference, maintain stable blood pressure, and reduce low-density lipoprotein and total cholesterol levels, and is considered safe and feasible to implement. However, more high-quality studies are needed to provide further evidence on the benefits of IF in improving other lipid levels.</p>","PeriodicalId":19385,"journal":{"name":"Nutricion hospitalaria","volume":" ","pages":"356-365"},"PeriodicalIF":2.5,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143503057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ángel Martínez González, Manuella González Nunes, Pedro Rodeiro Escobar, José Llópiz Castedo, Raquel Ruades Patiño, Joana Isabel Silva Sousa, Julia Rodríguez Pulian, Camila Sieiro Peña, Thalía Chantal Rodríguez Castiñeira, María Inmaculada Martínez González
{"title":"[Tolvaptan versus fluid restriction in the treatment of hyponatremia due to inappropriate antidiuretic hormone secretion: efficacy and safety analysis in a cohort study].","authors":"Ángel Martínez González, Manuella González Nunes, Pedro Rodeiro Escobar, José Llópiz Castedo, Raquel Ruades Patiño, Joana Isabel Silva Sousa, Julia Rodríguez Pulian, Camila Sieiro Peña, Thalía Chantal Rodríguez Castiñeira, María Inmaculada Martínez González","doi":"10.20960/nh.05558","DOIUrl":"10.20960/nh.05558","url":null,"abstract":"<p><strong>Introduction: </strong>Background and objectives: hyponatremia is a common in older and hospitalized patients, often caused by the syndrome of inappropriate antidiuretic hormone secretion (SIADH). This study compares the efficacy and safety of tolvaptan versus fluid restriction in patients with hyponatremia and SIADH. Materials and methods: an observational cohort study was conducted with 186 patients with hyponatremia (Na+ < 135 mmol/L) due to SIADH, treated at the Hospital Universitario de Pontevedra between 2015 and 2022. Of these, 86 were treated with tolvaptan (mean dose of 7.5 mg) and 100 with fluid restriction (1 liter of fluids per day). The primary endpoint was the normalization of sodium levels (Na ≥ 135 mmol/L). Results: tolvaptan was more effective than fluid restriction in correcting hyponatremia, increasing plasma sodium from 125.09 to 135.69 mmol/L in 4 days, compared to an increase from 126.44 to 130.5 mmol/L in 8 days with fluid restriction (p < 0.001). Mortality at 60 days was lower in the tolvaptan group (12.8 % vs. 32.8 %, p < 0.003). However, tolvaptan showed higher risks of sodium overcorrection (10.46 %) and polyuria (5.81 %), while fluid restriction was associated with greater dehydration, headache, and cramps. Conclusion: tolvaptan corrects hyponatremia more quickly and effectively than fluid restriction, although with a higher risk of overcorrection and polyuria, and is associated with lower 60-day mortality.</p>","PeriodicalId":19385,"journal":{"name":"Nutricion hospitalaria","volume":" ","pages":"137-144"},"PeriodicalIF":2.5,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Daniel Pejenaute-Larráyoz, Francisco Corbi, Sergi Matas
{"title":"[Effects of intermittent fasting and sports performance: a narrative review].","authors":"Daniel Pejenaute-Larráyoz, Francisco Corbi, Sergi Matas","doi":"10.20960/nh.05415","DOIUrl":"10.20960/nh.05415","url":null,"abstract":"<p><strong>Introduction: </strong>Recently, fasted exercise has generated interest for its potential to stimulate metabolic and performance adaptations. The present study aims to analyze the effects of fasting and fasted training on performance and metabolism, acutely and chronically. The databases Medline (PubMed), Physiotherapy Evidence Database (PEDro), Cochrane, and Google Scholar were searched. In total, 767 studies were identified. Of those, 51 studies were finally included. Acutely, exercise on fasting promotes fat oxidation at low and moderate intensities, while protein catabolism is not increased. Performance is not affected in efforts lower than 1 hour. Chronically, fasting generates greater efficiency in fat metabolism and the ability to regulate blood glucose in the long term, although it has not been possible to determine whether these findings improve sports performance. More research is needed in elite athletes, with high training loads and with a periodized approach to fasting.</p>","PeriodicalId":19385,"journal":{"name":"Nutricion hospitalaria","volume":" ","pages":"153-160"},"PeriodicalIF":2.5,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Haysla Xavier Martins, Jordana Herzog Siqueira, Carla Moronari de Oliveira Aprelini, Sheila Maria Alvim de Matos, Taísa Sabrina Silva Pereira, Maria Del Carmen Bisi Molina
{"title":"Change in leisure-time physical activity and perception of weight gain during the COVID-19 pandemic: results from the ELSA-Brasil Cohort.","authors":"Haysla Xavier Martins, Jordana Herzog Siqueira, Carla Moronari de Oliveira Aprelini, Sheila Maria Alvim de Matos, Taísa Sabrina Silva Pereira, Maria Del Carmen Bisi Molina","doi":"10.20960/nh.05294","DOIUrl":"10.20960/nh.05294","url":null,"abstract":"<p><strong>Introduction: </strong>Objective: this study aimed to identify the association between changes in Leisure-Time Physical Activity (LTPA) and Perceived Weight Gain (PWG) during the COVID-19 pandemic among participants enrolled in the Longitudinal Study of Adult Health (ELSA-Brasil). Methods: an observational longitudinal study utilizing data from the ELSA-Brasil, Wave 3 - W3 (2017-2019), and Wave-COVID - WC (July/2020 to February/2021). LTPA was assessed using the International Physical Activity Questionnaire, collected at both time points, while PWG was evaluated through a questionnaire in WC. Statistical analyses were performed using the SPSS 21.0, with significance set at p < 0.05. Results: among 4402 adults (57.8 % women), after adjusting for potential confounding variables, individuals who reduced their LTPA levels to the extent of changing their classification were more likely to experience PWG - specifically, those who were moderately active in W3 and became sedentary in WC (OR = 1.5 [95 % CI, 1.2-1.9]) or had low LTPA in WC (OR = 1.6 [95 % CI, 1.2-2.1]), and those who were highly active in W3 and presented a low level of LTPA in WC (OR = 2.3 [95 % CI, 1.05-5.4]). Conclusion: our findings suggest that individuals who engaged in LTPA (moderately and highly levels) during W3 but transitioned to insufficiently active or sedentary lifestyles during the WC, were more likely to experience PWG.</p>","PeriodicalId":19385,"journal":{"name":"Nutricion hospitalaria","volume":" ","pages":"105-116"},"PeriodicalIF":2.5,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}