Isabel Gómez-Ibáñez, Laura Gratacós-Santanach, Ana Pérez-Plasencia, Sonsoles García-Rodicio, Neus Sunyer-Esquerrà, Yaiza Ortuño-Ruiz, Carles Quiñones-Ribas
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引用次数: 0
Abstract
Introduction: valproic acid (VPA) is a drug with narrow therapeutic index (50-100 µg/mL) with a high pharmacokinetic variability due to plasma protein binding saturation (PPBU).
Case report: we present a clinical case of a 60-year-old patient under treatment with VPA, whose plasma VPA concentrations were analyzed and a decrease in these concentrations was detected when administrated with protein supplement. When the intake was spaced out, VPA serum concentrations returned to the therapeutic range.
Discussion: administration with food does not appear to be important according to the majority of the literature available to date. However, this case seems to show that protein supplements can interact with VPA and it is important to space out the intake between them to minimize variation in plasma concentrations.
期刊介绍：
The journal Nutrición Hospitalaria was born following the SENPE Bulletin (1981-1983) and the SENPE journal (1984-1985). It is the official organ of expression of the Spanish Society of Clinical Nutrition and Metabolism. Throughout its 36 years of existence has been adapting to the rhythms and demands set by the scientific community and the trends of the editorial processes, being its most recent milestone the achievement of Impact Factor (JCR) in 2009. Its content covers the fields of the sciences of nutrition, with special emphasis on nutritional support.
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