Nutricion hospitalaria最新文献

{"title":"Association between body mass index, muscle-to-fat ratio, and handgrip strength-to-BMI ratio with physical fitness in children from North Macedonia.","authors":"Arijana Llagjeviq-Govori, Seryozha Gontarev, Agon Saiti, Slavica Novacevska, Jana Karsakovska Dimitrievska, Vlatko Nedelkovski","doi":"10.20960/nh.05417","DOIUrl":"10.20960/nh.05417","url":null,"abstract":"<p><strong>Introduction: </strong>Background: this cross-sectional study, conducted on a convenience sample of 2197 Macedonian primary school children, aimed to examine how certain anthropometric indices (body mass index (BMI), muscle-fat ratio (MFR), hand grip strength-BMI ratio) are related to the physical fitness of individuals. Methods: the sample was split into two groups based on gender: 1096 boys and 1101 girls (average age 8.1 ± 1.3 years). Data on anthropometric measurements (BMI, MFR) were taken and the physical fitness was measured with the following tests: sit and reach, handgrip strength, standing long jump, sit-ups 30 sec., shuttle run 4 x 10 m, and 20 meters shuttle-run test (20-mSRT). Results: the findings from the study indicate that children with normal weight exhibit superior levels of cardiorespiratory, muscular, and motor fitness in comparison to those who are categorized as obese, irrespective of gender. Both muscle‑to‑fat ratio (MFR), and grip strength-to-BMI ratio showed correlation with most fitness tests. Grip strength-to-BMI ratio showed a positive correlation with the results of the handgrip test in boys and girls. Conclusion: in this population, BMI, MFR, and handgrip strength-to-BMI ratio can serve as indicators of health and physical fitness.</p>","PeriodicalId":19385,"journal":{"name":"Nutricion hospitalaria","volume":" ","pages":"26-32"},"PeriodicalIF":2.5,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142605383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal effects of vitamin D on leukemia risk: insights from two-sample Mendelian randomization analysis.","authors":"Shupeng Chen, Meiling Zhang, Yao Gao, Yingjian Zeng","doi":"10.20960/nh.05541","DOIUrl":"10.20960/nh.05541","url":null,"abstract":"<p><strong>Introduction: </strong>Background: vitamin D plays a crucial role in immune regulation, anti-inflammatory processes, and tumor suppression, but its relationship with leukemia risk remains unclear. This study aims to evaluate the causal relationship between vitamin D levels and the risk of different types of leukemia through a two-sample Mendelian randomization (MR) analysis. Methods: data from large-scale genome-wide association studies (GWAS) were used, and genetic variants associated with vitamin D were selected as instrumental variables. The relationship between vitamin D levels and the risk of acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), chronic lymphocytic leukemia (CLL), and chronic myeloid leukemia (CML) was examined. The inverse variance weighted (IVW) method was applied as the primary analytical approach. Heterogeneity was assessed through Cochran's Q test, pleiotropy was evaluated using the MR-Egger intercept, and sensitivity analyses were performed to ensure the robustness of the results. Results: MR analysis showed a significant inverse association between serum 25-hydroxyvitamin D levels and the risk of CML (OR = 0.44, 95 % CI: 0.25-0.78, p = 0.005), suggesting a potential protective effect of vitamin D against CML. No significant causal relationships were found between vitamin D levels and the risks of AML, ALL, or CLL. Sensitivity analyses supported the robustness of these findings, with no evidence of heterogeneity or pleiotropy. Conclusion: the findings indicate that higher vitamin D levels may reduce the risk of CML, while the effects on other types of leukemia require further investigation. The potential role of vitamin D in leukemia prevention warrants more mechanistic studies and clinical validation.</p>","PeriodicalId":19385,"journal":{"name":"Nutricion hospitalaria","volume":" ","pages":"311-318"},"PeriodicalIF":2.5,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Nutritional risk assessment by STAMP according to type of congenital heart disease in pediatric patients admitted to a reference hospital].","authors":"José de Jesús Vargas Lares, Lisset Del Carmen López Segovia, Jonathan Antonio Casillas Moreno, Juan Carlos Barrera de León","doi":"10.20960/nh.05421","DOIUrl":"10.20960/nh.05421","url":null,"abstract":"<p><strong>Introduction: </strong>Introduction: patients with congenital heart disease are considered to be at high nutritional risk due to alterations in the metabolism of the underlying pathology and extracardiac factors. The STAMP (Screening Tool for the Assessment of Malnutrition in Paediatrics) is the only tool validated in our country in a pediatric population for nutritional screening. Objective: to evaluate nutritional risk by STAMP screening in pediatric patients according to type of congenital heart disease. Material and methods: an analytical cross-sectional study in 2023 in a pediatric reference hospital. Nutritional status was determined by Z scores based on WHO 2006/CDC 2000 child growth standards. The STAMP questionnaire was administered to establish nutritional risk. Inferential statistics with the Chi-squared and Mann-Whitney U-test were used. Spearman's correlation coefficient was used. Analyses were carried out using the SPSS V25 statistical package. Results: 113 patients were included, male (n = 57, 50.4 %) and female (n = 56, 49.6 %). The most common age group was that of infants (n = 47, 45 %). Acute or chronic nutritional status impairment affected n = 50 (44.3 %) subjects. Cyanogenous congenital heart diseases had a greater impact on weight, height, average arm circumference and height/age, WBC/age indices. Two nutritional risk groups were established by STAMP: intermediate risk, n = 74 (65.5 %), and high risk, n = 39 (34.5 %). The greatest impact on anthropometric parameters was associated with elevated risk by STAMP, p = 0.000. The type of congenital heart disease was not associated with a greater increase in nutritional risk by STAMP (p = 0.76). There was no correlation of STAMP score with biochemical parameters. Conclusion: patients with congenital heart disease will have an intermediate risk per STAMP. The type of congenital heart disease is not related to a greater increase in nutritional risk due to STAMP.</p>","PeriodicalId":19385,"journal":{"name":"Nutricion hospitalaria","volume":" ","pages":"33-39"},"PeriodicalIF":2.5,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142687771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of supplementation with prebiotic fiber on the gut microbiota of a group of older people with Parkinson's disease from the city of Santiago de Chile. A pilot study.","authors":"Paula García Milla, Gema Nieto Martínez, Mario Maulen, Carlos Tapia, Waldo Díaz","doi":"10.20960/nh.05272","DOIUrl":"10.20960/nh.05272","url":null,"abstract":"<p><strong>Introduction: </strong>Introduction: Parkinson's disease (PD) is the second most common neurodegenerative disorder worldwide. It has been demonstrated that there is a correlation between the increase in bacterial abundance and the severity of certain symptoms associated with PD. Aim: the aim of this pilot study was to analyze the effect of supplementation with prebiotic fiber on the gut microbiota (GM) and nutritional status of elderly volunteers with Parkinson's disease. Methodology: this is a pilot study of pre and post intervention with prebiotic fiber. All subjects involved were volunteers with PD, who were given nutritional counseling and gut microbiota measured on time cero and after 30 days of prebiotic fiber intervention. Results: a statistically significant difference was found in calf circumference (p 0.0422) after the intervention with prebiotic fiber. GM analyses show an initial difference in gut bacterial abundance of older people with PD and people without PD. Furthermore, our results showed a difference in bacterial families and genera after the supplementation with prebiotic fiber. in addition, we found a statistically significant difference in the val-ue of circumference calf and a trend in the improvement of body weight, Body mass index (BMI), neck circumference, arm circumference, brachial area, and Diet Quality Questionnaire (DQQ) for older adults. Conclusion: supplementation with 20 g of prebiotic fiber for 30 days could modify the intestinal microbiota, reducing bacterial genera and phylum that are abundant in Park-inson's disease, such as Verrucomicrobia. Therefore, the use of prebiotic fiber could represent an alternative to improve intestinal health and nutritional status of people with Parkinson's disease.</p>","PeriodicalId":19385,"journal":{"name":"Nutricion hospitalaria","volume":" ","pages":"232-242"},"PeriodicalIF":2.5,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143503058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"25(OH)D concentrations are not associated with adiposity indicators, but with the stage of immunodeficiency in people with HIV/AIDS.","authors":"Andrea Nunes Mendes de Brito, Iara Katrynne Fonsêca Oliveira, Nayra do Socorro Caldas Carvalho de Almeida Teixeira, Dorcas Lamounier Costa, Poliana Cristina Almeida Fonseca, Patrícia Helen Rondó, Liania Alves Luzia, Isabel Oliveira Aires, Adriana de Azevedo Paiva","doi":"10.20960/nh.05228","DOIUrl":"10.20960/nh.05228","url":null,"abstract":"<p><strong>Introduction: </strong>Objective: this study assessed the association between serum 25(OH)D concentrations and anthropometric indicators of adiposity in people living with HIV/AIDS taking highly active antiretroviral therapy. Methods: the study included 244 people living with HIV/AIDS who received outpatient care at the Institute of Tropical Diseases in the city of Teresina, Brazil. Sociodemographic, clinical, anthropometric and laboratory characteristics were examined. Serum 25(OH)D was analyzed by high-performance liquid chromatography in accordance with the Vitamin D Standardization Program. Multiple linear regression analysis adjusted for gender, age, disease stage and duration of highly active antiretroviral therapy was performed to assess the association between 25(OH)D concentrations and adiposity indicators. Results: the study included 142 (58.2 %) men and 102 (41.8 %) women, with a mean (± SD) age of 39.13 (± 10.83) years. A proportion of 57.8 per cent of the participants had insufficient concentrations of 25(OH)D below 30 ng/mL. Individuals in more advanced stages of immunodeficiency had lower concentrations of 25(OH)D (30.30 ± 16.10 ng/mL) compared to those with mild immunodeficiency or no immunodeficiency. There was no significant association between 25(OH)D concentrations and any of the adiposity indicators considered in this study. Conclusion: vitamin D concentrations in people living with HIV/AIDS using antiretroviral therapy are related to the degree of immunosuppression, but not to the individual's adiposity status.</p>","PeriodicalId":19385,"journal":{"name":"Nutricion hospitalaria","volume":" ","pages":"89-96"},"PeriodicalIF":2.5,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[How to choose a research design?]","authors":"Joaquín González Aroca","doi":"10.20960/nh.05626","DOIUrl":"10.20960/nh.05626","url":null,"abstract":"<p><strong>Introduction: </strong></p>","PeriodicalId":19385,"journal":{"name":"Nutricion hospitalaria","volume":" ","pages":"394-395"},"PeriodicalIF":2.5,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of the consumption of cashew nut (Anacardium occidentale l.) flour-based biscuits in overweight children: a pilot randomized clinical trial.","authors":"Letícia Bezerra Brito, Brenna Oliveira Leal, Janaína Ribeiro da Silva, Kelly Maria Pereira Barbosa, Vinícius Teixeira da Silva, Andressa Silva Costa, Yroan Paula Landim, Lívia Maia Pascoal, Marcelino Santos Neto, Ana Lúcia Fernandes Pereira, Virgínia Kelly Gonçalves Abreu, Virlane Kelly Lima Hunaldo, José de Ribamar Macedo Costa, Ana Cristina Pereira de Jesus Costa, Márcio Flávio Moura de Araújo","doi":"10.20960/nh.05241","DOIUrl":"10.20960/nh.05241","url":null,"abstract":"<p><strong>Introduction: </strong>Background: cashew nut is an almond known for its cardiovascular benefits in adults and weight gain effects in malnourished children, as supported by research. However, its impact on overweight children remains unexplored. Objective: to analyze the effect of consuming biscuits made with cashew nut flour on the blood glucose and serum triglyceride levels of children with overweight/obesity over four weeks. Methods: a pilot, randomized, open-label clinical study was conducted with 19 overweight children (11 in intervention group 1 [G1] and 8 in group 2 [G2], aged between 7 and 15 years. Over four consecutive weeks, they consumed, daily, three biscuits with 50 % cashew nut flour composition (G1) and six biscuits with 50 % cashew nut flour composition (G2). The biomarkers analyzed were glycated hemoglobin (HbA1c), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and total cholesterol (TC) at baseline and seven days post-biscuit consumption. Results: post-experiment, the TG (p = 0.153), HDL-C (p = 0.895), and TC (p = 0.122) biomarkers showed no significant changes. LDL-C levels experienced a slight but statistically significant increase of 0.52 % across all participants (p = 0.031). In contrast, non-HDL cholesterol levels saw a minor yet significant reduction of -1.7 % in serum concentration (p = 0.014). Independent of group allocation, the participants' HbA1c and average blood glucose levels significantly decreased by 12.1 % (p < 0.001) and 17.9 % (p < 0.001), respectively (Cohen's Δ = 1, in both instances). Conclusion: consumption of biscuits containing cashew nut flour by overweight/obese children positively affected the reduction of blood glucose and non-HDL cholesterol biomarkers in both groups, regardless of the formulations used.</p>","PeriodicalId":19385,"journal":{"name":"Nutricion hospitalaria","volume":" ","pages":"19-25"},"PeriodicalIF":2.5,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of 3-day fasting on secretory IgA concentration in the saliva and lymphotoxin alpha expression in healthy volunteers: a proof of concept study.","authors":"Gabriela Quiroz-Olguín, Gabriela Gutiérrez-Salmeán, Angélica I Borja-Margno, Adriana Flores-López, Martha Guevara-Cruz, Francisco Enrique Gómez, Aurora E Serralde-Zúñiga","doi":"10.20960/nh.05249","DOIUrl":"10.20960/nh.05249","url":null,"abstract":"<p><strong>Introduction: </strong>Background: animal studies have shown that enteral stimuli play an important role in modulating gut-associated lymphoid tissue thus fasting may exert detrimental effects on such. Objective: the main objectives of this study were 1) to evaluate the effect of 3-day fasting on secretory immunoglobulin A (S-IgA) in parotid saliva and 2) to determine the levels of lymphotoxin (LT) transcription in peripheral blood mononuclear cells (PBMNC) from healthy volunteers as a proxy for studying GALT health. Methods: these adult volunteers had fasted for three days as part of a cultural ritual. Eleven volunteers (seven men and four women) with a median age of 43 (40-56) were included. Parotid saliva and blood samples were collected on day 0 (no fasting) and three days after fasting. Parotid saliva was obtained using a modified on-Crittenden device, and S-IgA was quantified using ELISA. Total RNA was isolated from peripheral blood mononuclear cells, and the level of lymphotoxin (LT) mRNA expression was determined by RT-PCR. Lipopolysaccharide (LPS), IL-10 (interleukin), tumor necrosis factor (TNF)α, body composition and other metabolic indicators were measured. Results: median BMI was 27.3 kg/m2 (24.9-29.1). After 3 days of fasting, there were no significant differences in S-IgA concentrations (p = 0.657), LT expression (p = 0.063), LPS (p = 0.182), nor IL-10 (p = 0.110). We found a statistical difference in TNFα levels (13.5 vs 11.3 pg/mL; p = 0.005) between the 0 and 3-day samples; TNFα decreased after fasting. Conclusion: further studies are needed to clarify the role of LT in the production of S-IgA and its relationship with nutritional status and inflammatory factors.</p>","PeriodicalId":19385,"journal":{"name":"Nutricion hospitalaria","volume":" ","pages":"131-136"},"PeriodicalIF":2.5,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adequacy of financing and prescription of home enteral nutrition. Are things being done right?","authors":"Sara Ferro-Rodríguez, Paloma Castellano-Copa, Arón Misa-García, Alba Díaz-Fernández, Pablo Moya-Martínez","doi":"10.20960/nh.05535","DOIUrl":"10.20960/nh.05535","url":null,"abstract":"<p><strong>Introduction: </strong>Introduction: this study focuses on Home Enteral Nutrition (HEN), whose use has grown enormously in recent years. Objective: to analyze the prescriptions and, in addition, determine whether National Health System (NHS) funding criteria are met and to explore whether overcosts exist. Methods: a retrospective observational study was conducted on 844 patients (895 episodes) who received HEN, using information obtained from the healthcare database. Demographic, clinical, dietary, and economic data were analyzed. Results: in 9.7 % of the episodes analyzed, the funding criteria were met; in 15.1 %, ≥ 50 % kcal/day required was provided through HEN. During the 3 months of the study an average of 118.1 ± 86.8 units/patient were dispensed, which resulted in an average monthly expenditure of € 69.9 ± 66.3/patient. To go to the hospital to collect HEN, an average of 78.1 ± 69.5 km/patient was traveled, with an associated average monthly fuel cost of € 2.65 ± 2.39/patient. The additional expenditure associated with prescriptions not aligned with the funding criteria was estimated at € 574,259.44/year in the health area analyzed, with a quota of 200,000 inhabitants. Conclusions. the results of this study show a divergence in the use of HEN compared to the conditions established by the NHS for the funding of this treatment. Given the low compliance rate and the current scientific evidence on the use of HEN, it may be necessary to re-evaluate the funding criteria to make them more representative of clinical evidence and actual practice.</p>","PeriodicalId":19385,"journal":{"name":"Nutricion hospitalaria","volume":" ","pages":"201-210"},"PeriodicalIF":2.5,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143503054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triponderal Mass Index rather than Body Mass Index in discriminating high adiposity in Brazilian children and adolescents.","authors":"Fabio Ued, Murilo Jose Silveira Castro, Laura Ruy Bardi, Luiz Del Ciampo, Edson Zangiacomi Martinez, Ivan Savioli Ferraz, Andrea Aparecida Contini, Elza Mello, Carlos Alberto Nogueira-de-Almeida","doi":"10.20960/nh.05432","DOIUrl":"10.20960/nh.05432","url":null,"abstract":"<p><strong>Introduction: </strong>Introduction: body mass index (BMI) is used worldwide to track excess weight; however, it has limitations in predicting body fat percentage (BF%). Triponderal mass index (TMI) has been studied as an alternative indicator to predict BF%. Objective: to compare BMI and TMI as predictors of BF% and develop TMI cutoff points for screening high adiposity in Brazilian children and adolescentes. Methods: a cross-sectional and multicenter study conducted with 226 individuals aged 5 to 17 years from two municipalities in the Southeast and South regions of Brazil. BF% was assessed by bioimpedancemetry. The association between BMI and TMI with BF% was assessed using generalized additive models. ROC curve analyzes were performed to verify the accuracy of BMI and TMI in detecting high adiposity. The areas under the curve (AUC) of BMI and TMI were compared using non-parametric analysis. The TMI cutoff points were obtained using Youden's J index. Results: bioimpedancemetry detected high BF% in 54.1 % (95 % confidence interval [CI], 44.8-63.2) of boys and 63.5 % (95 % CI, 54.5-71.9) of girls. TMI was able to predict BF% better than BMI in males, presenting a higher R-square (0.737 versus 0.646, respectively). The TMI presented AUC significantly greater than BMI to indicate high adiposity in the entire population (p = 0.007) and in females (p = 0.014). TMI cutoff points for different age groups and sex were presented. Conclusion: TMI proved to be a better predictor of excess body fat than BMI in Brazilian children and adolescents.</p>","PeriodicalId":19385,"journal":{"name":"Nutricion hospitalaria","volume":" ","pages":"40-47"},"PeriodicalIF":2.5,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142605398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}