Sonsoles Botella Martínez, Nerea Varo Cenarruzabeitia, María Jesús Ribelles Segura, Elena Goñi Gironés, Estrella Petrina Jáuregui, Ana Zugasti Murillo, Amelia Marí Sanchís, Henry Redon Barragán, Isabel Escuer Núñez, Ana Hernández Moreno, Coro Miranda Murúa, Inés Eguaras Córdoba, Aura Daniela Urribarri Marín
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引用次数: 0
Abstract
Introduction: bariatric surgery is an effective treatment but weight loss does not occur only at the expense of fat mass and preserving muscle mass is a priority.
Objective: to evaluate the improvement in nutritional parameters of patients undergoing bariatric surgery after supplementation with beta-hydroxy-β-methylbutyrate (HMB).
Methodology: intervention study comparing 2 types of protein supplementation (with and without HMB) in the 3 months after surgery. All patients underwent a baseline and 3-month anthropometric, body composition, dynamometry and analytical study with usual nutritional determination, inflammation markers (CRP and IL-6), muscle markers (irisin, CK) and MRO (CTX, P1NP, sclerostin). Adherence was assessed and physical activity was recorded.
Results: a total of 24 patients (87.5 % women) with a mean age of 52 ± 8 years were included. There were no statistically significant differences (p > 0.05) between intervention vs control in weight loss (17.5 ± 1.3 vs 19.1 ± 1.7 kg), MME (3.07 ± 1.7 vs 3.06 ± 136 kg), MG (12.9 ± 0.8 vs 14.7 ± 1.4 kg) or in dynamometry. Prealbumin levels in the intervention group were significantly higher (21 ± 1 vs 18 ± 0.8 mg/dl, p = 0.04) but there were no significant differences in the rest of the analytical markers. Significant changes in weight and fat mass were observed depending on physical activity.
Conclusions: after bariatric surgery, a significant weight reduction has been seen both at the expense of fat mass and lean mass in all patients. HMB supplementation has not shown statistically significant differences compared to the other protein supplementation to preserve muscle mass or function.
简介：减肥手术是一种有效的治疗方法，但减肥并不仅仅是以牺牲脂肪量为代价，保持肌肉质量是一个优先考虑的问题。目的：评价减肥手术患者补充β-羟基-β-甲基丁酸酯（HMB）后营养参数的改善情况。方法：干预研究，比较术后3个月内两种蛋白质补充（有和没有HMB）。所有患者都进行了基线和3个月的人体测量、身体组成、动力学测量和分析研究，包括常规的营养测定、炎症标志物（CRP和IL-6）、肌肉标志物（鸢尾素、CK）和MRO （CTX、P1NP、sclerostin）。评估依从性并记录身体活动。结果：共纳入24例患者（87.5%为女性），平均年龄52±8岁。干预组与对照组在减重（17.5±1.3 vs 19.1±1.7 kg）、MME（3.07±1.7 vs 3.06±136 kg）、MG（12.9±0.8 vs 14.7±1.4 kg）和动力学方面均无统计学差异（p < 0.05）。干预组的前白蛋白水平显著高于对照组（21±1 vs 18±0.8 mg/dl, p = 0.04），但其余分析指标差异无统计学意义。体重和脂肪量的显著变化取决于体力活动。结论：在减肥手术后，所有患者的脂肪量和瘦肉量都有显著的减轻。与其他蛋白质补充剂相比，补充HMB在保持肌肉质量或功能方面没有统计学上的显著差异。
期刊介绍：
The journal Nutrición Hospitalaria was born following the SENPE Bulletin (1981-1983) and the SENPE journal (1984-1985). It is the official organ of expression of the Spanish Society of Clinical Nutrition and Metabolism. Throughout its 36 years of existence has been adapting to the rhythms and demands set by the scientific community and the trends of the editorial processes, being its most recent milestone the achievement of Impact Factor (JCR) in 2009. Its content covers the fields of the sciences of nutrition, with special emphasis on nutritional support.
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