Nuclear Medicine and Molecular Imaging最新文献

{"title":"\"Snake in the Orchard\" Sign on ¹⁸F-FDG PET/CT: A Rare Presentation of Supradiaphragmatic Tumor Thrombosis in Recurrent Breast Carcinoma.","authors":"Srinivas Ananth Kumar, Sathya Narayanan, Manikya Ys, Harish Goyal, Dhanapathi Halanaik","doi":"10.1007/s13139-025-00953-x","DOIUrl":"10.1007/s13139-025-00953-x","url":null,"abstract":"","PeriodicalId":19384,"journal":{"name":"Nuclear Medicine and Molecular Imaging","volume":"60 2","pages":"148-150"},"PeriodicalIF":2.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13031577/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147574916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple Head and Neck Paragangliomas in a Patient with Succinate Dehydrogenase Subunit D Gene Mutation Detected on ⁶⁸Ga-DOTATATE PET/CT.","authors":"Clare Cooper, Ravishankar Pillenahalli Maheshwarappa","doi":"10.1007/s13139-025-00940-2","DOIUrl":"10.1007/s13139-025-00940-2","url":null,"abstract":"","PeriodicalId":19384,"journal":{"name":"Nuclear Medicine and Molecular Imaging","volume":"60 2","pages":"140-142"},"PeriodicalIF":2.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13031702/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147574922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypophosphatemic Osteomalacia Caused by Adefovir-Induced Fanconi Syndrome.","authors":"Yeon-Hee Han, Hwan-Jeong Jeong, Seok Tae Lim","doi":"10.1007/s13139-025-00944-y","DOIUrl":"10.1007/s13139-025-00944-y","url":null,"abstract":"","PeriodicalId":19384,"journal":{"name":"Nuclear Medicine and Molecular Imaging","volume":"60 2","pages":"151-154"},"PeriodicalIF":2.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13031612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147574957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Imaging to Insight: The Expanding Role of F-18 FDG PET/CT in Multiple Myeloma.","authors":"Hee Jeong Cho, Chae Moon Hong","doi":"10.1007/s13139-025-00957-7","DOIUrl":"10.1007/s13139-025-00957-7","url":null,"abstract":"","PeriodicalId":19384,"journal":{"name":"Nuclear Medicine and Molecular Imaging","volume":"60 2","pages":"61-63"},"PeriodicalIF":2.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13031442/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147574873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation Between Clinical Characteristics and Image Parameters of Preoperative ¹⁸F-fluorocholine PET/CT in Hyperparathyroidism Patients.","authors":"Seokkyu Jeong, Jeonghoon Kim, Joonhee Gook, Hyojung Kim, Young Seok Cho, Sun Wook Kim, Jun-Ho Choe, Young Lyun Oh, Joon Young Choi, Hyunjong Lee","doi":"10.1007/s13139-025-00947-9","DOIUrl":"10.1007/s13139-025-00947-9","url":null,"abstract":"<p><strong>Purpose: </strong>¹⁸F-fluorocholine (FCH) positron emission tomography/computed tomography (PET/CT) is a valuable tool for accurately localizing hyperfunctioning parathyroid lesions. This study investigates the diagnostic value of imaging parameters obtained from preoperative FCH PET/CT for differentiating parathyroid adenoma from hyperplasia in patients with hyperparathyroidism, while considering chronic kidney disease (CKD) status and associated biochemical markers.</p><p><strong>Methods: </strong>A retrospective analysis of 108 patients with 133 lesions who underwent preoperative FCH PET/CT was conducted. PET parameters, including mean and maximum standardized uptake values (SUVmean, SUVmax), choline uptake lesion volume (CULV; volume of the lesion with SUV ≥ 2.5), and total lesion choline uptake (TLCU; calculated as the product of SUVmean and CULV), were measured. Correlations between PET parameters and clinical factors were analyzed using Spearman correlation analysis. Logistic regression analysis was performed to assess the ability of PET parameters and clinical factors to differentiate parathyroid adenoma from hyperplasia.</p><p><strong>Results: </strong>Significant positive correlations were observed between PTH levels and PET parameters across all patients, with these correlations being notably stronger in CKD-positive patients. CKD was strongly associated with hyperplasia (OR = 60.00, <i>p</i> < 0.001). In multivariable logistic regression analysis adjusted for CKD status, SUVmean remained a significant independent predictor of parathyroid adenoma (OR = 0.306, <i>p</i> = 0.048).</p><p><strong>Conclusion: </strong>FCH PET/CT reflects the metabolic and pathological characteristics of hyperfunctioning parathyroid lesions. CKD status was a strong independent predictor of hyperplasia, whereas SUVmean independently distinguished adenoma from hyperplasia.</p>","PeriodicalId":19384,"journal":{"name":"Nuclear Medicine and Molecular Imaging","volume":"60 2","pages":"103-112"},"PeriodicalIF":2.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13031480/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147574970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Diagnostic Pitfall: Pulmonary Arterial Hypertension Presenting with Multiple Perfusion Defects Mimicking Pulmonary Embolism.","authors":"Basak Soydas-Turan, Eser Lay Ergun","doi":"10.1007/s13139-025-00945-x","DOIUrl":"10.1007/s13139-025-00945-x","url":null,"abstract":"","PeriodicalId":19384,"journal":{"name":"Nuclear Medicine and Molecular Imaging","volume":"60 2","pages":"143-145"},"PeriodicalIF":2.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13031581/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147574882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coefficient of Variation-Based Measurement Uncertainty: Is it Normally Distributed?","authors":"Hyungyu Kang, Jong Jin Lee","doi":"10.1007/s13139-025-00967-5","DOIUrl":"10.1007/s13139-025-00967-5","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to empirically evaluate the normality of internal quality control (IQC) data used for coefficient of variation (CV%)-based measurement uncertainty (MU) estimation in clinical laboratories.</p><p><strong>Methods: </strong>IQC data from 44 nuclear medicine assays were retrospectively analyzed. Ninety-seven analyte-control datasets were classified by replicate count as limited (< 15), moderate (15-29), or sufficient (≥ 30). Normality was assessed using the Shapiro-Wilk test (α = 0.05) for datasets with at least 15 replicates, supported by Q-Q plots and histograms. Subgroup comparisons between moderate and sufficient groups were conducted using Fisher's exact and Pearson's chi-square tests. The relationship between precision and normality was evaluated by comparing CV% between Shapiro-Wilk pass and fail groups using the Mann-Whitney U test.</p><p><strong>Results: </strong>Of 97 datasets, 20 were limited, 32 moderate, and 45 sufficient. Normality testing was performed on 77 datasets with ≥ 15 replicates; 51.9% passed the Shapiro-Wilk test, while 48.1% failed. Pass rates did not differ between the moderate and sufficient groups (<i>p</i> = 0.64), and CV% showed no significant difference between normal and non-normal datasets (<i>p</i> = 0.219).</p><p><strong>Conclusion: </strong>Nearly half of IQC datasets failed to meet normality even with sufficient replicates, and CV% was not associated with distributional behavior. Therefore, CV% alone should not justify Type A MU without verifying normality. When normality is not established, a rectangular distribution may provide a conservative alternative, thereby improving the reliability of MU estimates and support safer, more accurate clinical decision-making.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s13139-025-00967-5.</p>","PeriodicalId":19384,"journal":{"name":"Nuclear Medicine and Molecular Imaging","volume":"60 2","pages":"113-120"},"PeriodicalIF":2.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13031467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147574921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nuclear Medicine in Depression: Insights into Brain Metabolism and Treatment Responses: a Literature Review.","authors":"Raydel BrianKwee Amalo, Hendra Budiawan, Achmad Hussein Sundawa Kartamihardja","doi":"10.1007/s13139-025-00968-4","DOIUrl":"10.1007/s13139-025-00968-4","url":null,"abstract":"<p><p>Depression is a prevalent mental health disorder with significant global impact, often accompanied by alterations in brain activity and neurotransmitter systems. Nuclear medicine, especially Positron Emission Tomography (PET) and Single-Photon Emission Computed Tomography (SPECT), offers valuable insights into the neurobiological mechanisms underlying depression. These imaging modalities enable non-invasive assessment of cerebral glucose metabolism, neurotransmitter activity, and cerebral blood flow, which are often disrupted in individuals with depression. Advanced radiopharmaceuticals, including ¹⁸F-FDG PET, ¹²³I-ADAM SPECT, and ¹¹C-raclopride PET, have been utilized to explore the pathophysiology of depression and monitor responses to various treatment strategies. This review discusses how nuclear medicine enhances the diagnosis, understanding, and personalized management of depression, with potential for guiding therapeutic interventions based on brain activity patterns and treatment responses.</p>","PeriodicalId":19384,"journal":{"name":"Nuclear Medicine and Molecular Imaging","volume":"60 2","pages":"93-102"},"PeriodicalIF":2.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13031423/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147574944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MR Pulse Sequences for Parathyroid Adenoma Imaging Using [¹⁸F]fluorocholine PET/MR in Primary Hyperparathyroidism.","authors":"Shaza K Isenschmid, Jan A Schaab, Antonio G Gennari, Junko Inoue Inukai, Grégoire B Morand, Simon A Mueller, Niels J Rupp, Bert-Ram Sah, Victoria Schober, Urs J Muehlematter, Petra Petranović Ovčariček, Luca Giovanella, Virginia Liberini, Philipp A Kaufmann, Michael Messerli, Martin W Huellner","doi":"10.1007/s13139-025-00961-x","DOIUrl":"10.1007/s13139-025-00961-x","url":null,"abstract":"<p><strong>Purpose: </strong>Currently, no standardized anatomic magnetic resonance (MR) imaging protocol exists for detecting parathyroid adenomas. We analyzed various MR pulse sequences to evaluate their performance in visualizing histopathologically confirmed parathyroid adenomas in patients with primary hyperparathyroidism (pHPT) undergoing [¹⁸F]fluorocholine positron emission tomography (PET)/MR.</p><p><strong>Methods: </strong>This retrospective study included 128 adenomas in 110 patients with biochemically confirmed pHPT who underwent [¹⁸F]fluorocholine PET/MR at our institution between December 2020 and October 2023. Two radiologists independently characterized the lesions (as upper pole, lower pole, or ectopic adenomas). Surgical reports and histopathology served as reference standard. Lesion conspicuity, delineation, and size were compared on axial T1-weighted fast spin echo sequence (T1w FSE) and axial T2-weighted iterative decomposition of water and fat with echo asymmetry and least-squares estimation (IDEAL) sequence with water image reconstruction (T2w FSE flex water). Interreader agreement was determined using Cohen's kappa; differences were analyzed using Wilcoxon signed-rank test.</p><p><strong>Results: </strong>Parathyroid adenomas had significantly higher conspicuity, superior delineation, and were larger (<i>p</i> < 0.001) on T2w FSE flex water images compared to T1w FSE images. While these differences were maintained in the subgroup analysis for upper and lower pole adenomas, ectopic adenomas were of similar size on both MR pulse sequences (<i>p</i> = 0.646).</p><p><strong>Conclusion: </strong>T2w FSE flex water offers significantly better visualization of parathyroid adenomas compared to T1w FSE, especially in orthotopic lesions. These results support the targeted use of such a limited MR protocol as part of PET/MR in the preoperative assessment of patients with pHPT.</p>","PeriodicalId":19384,"journal":{"name":"Nuclear Medicine and Molecular Imaging","volume":"60 2","pages":"121-130"},"PeriodicalIF":2.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13031590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147574915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inverted Y Sign: Infected Aortic Graft Thrombosis in a Patient with Takayasu's Arteritis.","authors":"Srinivas Ananth Kumar, Madhur Kumar Srivastava","doi":"10.1007/s13139-025-00948-8","DOIUrl":"10.1007/s13139-025-00948-8","url":null,"abstract":"","PeriodicalId":19384,"journal":{"name":"Nuclear Medicine and Molecular Imaging","volume":"60 2","pages":"146-147"},"PeriodicalIF":2.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13031443/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147574946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}