Nguyen Thi Phuong, Mai Hong Son, Nong Thanh Ha, Chu Khanh Linh, Le Ngoc Ha
{"title":"血清甲状腺球蛋白翻倍时间对高甲状腺球蛋白、全身放射性碘显像阴性分化型甲状腺癌患者18F-FDG PET/CT预测复发/转移及预后的作用","authors":"Nguyen Thi Phuong, Mai Hong Son, Nong Thanh Ha, Chu Khanh Linh, Le Ngoc Ha","doi":"10.1007/s13139-025-00912-6","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the value of thyroglobulin doubling time (Tg-DT) in predicting <sup>18</sup>F-FDG PET/CT findings and clinical outcomes in differentiated thyroid cancer (DTC) patients with high thyroglobulin (Tg) level and negative <sup>131</sup>I whole-body scan (<sup>131</sup>I WBS).</p><p><strong>Materials and methods: </strong>188 DTC patients with Tg levels ≥ 10 ng/ml and negative <sup>131</sup>I WBS underwent <sup>18</sup>F-FDG PET/CT scan. Three last consecutive values of unstimulated Tg were used to calculate Tg doubling time (Tg-DT). ROC curve analysis was performed to determine the optimal thresholds of Tg-DT in predicting <sup>18</sup>F-FDG PET/CT results. Patients were followed up for at least 12 months after PET/CT scan. The Kaplan-Meier curve was used to estimate progression-free survival (PFS) and overall survival (OS). Cox regression analyses were conducted to identify factors significantly associated with PFS and OS.</p><p><strong>Results: </strong>The specificity and positive predictive value of Tg-DT for predicting <sup>18</sup>F-FDG PET/CT findings were 93.94%, and 92.6%, respectively, while those for Tg levels were 78.79% and 83.53% (<i>p</i> < 0.001). This study revealed that stimulated Tg and Tg-DT can predict disease progression and survival in DTC patients. Age > 55, distant metastasis on <sup>18</sup>F-FDG PET/CT, and Tg-DT ≤ 12 months were independent predictors of PFS. Distant metastasis and Tg-DT ≤ 12 months were independent prognostic factors for OS.</p><p><strong>Conclusion: </strong>Tg-DT is a valuable biomarker in predicting positive <sup>18</sup>F-FDG PET/CT findings in DTC patients with high Tg level and negative <sup>131</sup>I WBS. Along with distant metastases, Tg-DT ≤ 12 months is the only independent prognostic factor for PFS and OS.</p>","PeriodicalId":19384,"journal":{"name":"Nuclear Medicine and Molecular Imaging","volume":"59 4","pages":"246-254"},"PeriodicalIF":2.7000,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267783/pdf/","citationCount":"0","resultStr":"{\"title\":\"The Role of Serum Thyroglobulin Doubling Time in Predicting Recurrences/Metastasis on <sup>18</sup>F-FDG PET/CT and Prognosis of Differentiated Thyroid Cancer Patients with High Thyroglobulin and Negative Whole-Body Radioactive Iodine Scintigraphy.\",\"authors\":\"Nguyen Thi Phuong, Mai Hong Son, Nong Thanh Ha, Chu Khanh Linh, Le Ngoc Ha\",\"doi\":\"10.1007/s13139-025-00912-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>To evaluate the value of thyroglobulin doubling time (Tg-DT) in predicting <sup>18</sup>F-FDG PET/CT findings and clinical outcomes in differentiated thyroid cancer (DTC) patients with high thyroglobulin (Tg) level and negative <sup>131</sup>I whole-body scan (<sup>131</sup>I WBS).</p><p><strong>Materials and methods: </strong>188 DTC patients with Tg levels ≥ 10 ng/ml and negative <sup>131</sup>I WBS underwent <sup>18</sup>F-FDG PET/CT scan. Three last consecutive values of unstimulated Tg were used to calculate Tg doubling time (Tg-DT). ROC curve analysis was performed to determine the optimal thresholds of Tg-DT in predicting <sup>18</sup>F-FDG PET/CT results. Patients were followed up for at least 12 months after PET/CT scan. The Kaplan-Meier curve was used to estimate progression-free survival (PFS) and overall survival (OS). Cox regression analyses were conducted to identify factors significantly associated with PFS and OS.</p><p><strong>Results: </strong>The specificity and positive predictive value of Tg-DT for predicting <sup>18</sup>F-FDG PET/CT findings were 93.94%, and 92.6%, respectively, while those for Tg levels were 78.79% and 83.53% (<i>p</i> < 0.001). This study revealed that stimulated Tg and Tg-DT can predict disease progression and survival in DTC patients. Age > 55, distant metastasis on <sup>18</sup>F-FDG PET/CT, and Tg-DT ≤ 12 months were independent predictors of PFS. Distant metastasis and Tg-DT ≤ 12 months were independent prognostic factors for OS.</p><p><strong>Conclusion: </strong>Tg-DT is a valuable biomarker in predicting positive <sup>18</sup>F-FDG PET/CT findings in DTC patients with high Tg level and negative <sup>131</sup>I WBS. Along with distant metastases, Tg-DT ≤ 12 months is the only independent prognostic factor for PFS and OS.</p>\",\"PeriodicalId\":19384,\"journal\":{\"name\":\"Nuclear Medicine and Molecular Imaging\",\"volume\":\"59 4\",\"pages\":\"246-254\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2025-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267783/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nuclear Medicine and Molecular Imaging\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/s13139-025-00912-6\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/3/10 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nuclear Medicine and Molecular Imaging","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s13139-025-00912-6","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/3/10 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
The Role of Serum Thyroglobulin Doubling Time in Predicting Recurrences/Metastasis on 18F-FDG PET/CT and Prognosis of Differentiated Thyroid Cancer Patients with High Thyroglobulin and Negative Whole-Body Radioactive Iodine Scintigraphy.
Purpose: To evaluate the value of thyroglobulin doubling time (Tg-DT) in predicting 18F-FDG PET/CT findings and clinical outcomes in differentiated thyroid cancer (DTC) patients with high thyroglobulin (Tg) level and negative 131I whole-body scan (131I WBS).
Materials and methods: 188 DTC patients with Tg levels ≥ 10 ng/ml and negative 131I WBS underwent 18F-FDG PET/CT scan. Three last consecutive values of unstimulated Tg were used to calculate Tg doubling time (Tg-DT). ROC curve analysis was performed to determine the optimal thresholds of Tg-DT in predicting 18F-FDG PET/CT results. Patients were followed up for at least 12 months after PET/CT scan. The Kaplan-Meier curve was used to estimate progression-free survival (PFS) and overall survival (OS). Cox regression analyses were conducted to identify factors significantly associated with PFS and OS.
Results: The specificity and positive predictive value of Tg-DT for predicting 18F-FDG PET/CT findings were 93.94%, and 92.6%, respectively, while those for Tg levels were 78.79% and 83.53% (p < 0.001). This study revealed that stimulated Tg and Tg-DT can predict disease progression and survival in DTC patients. Age > 55, distant metastasis on 18F-FDG PET/CT, and Tg-DT ≤ 12 months were independent predictors of PFS. Distant metastasis and Tg-DT ≤ 12 months were independent prognostic factors for OS.
Conclusion: Tg-DT is a valuable biomarker in predicting positive 18F-FDG PET/CT findings in DTC patients with high Tg level and negative 131I WBS. Along with distant metastases, Tg-DT ≤ 12 months is the only independent prognostic factor for PFS and OS.
期刊介绍：
Nuclear Medicine and Molecular Imaging (Nucl Med Mol Imaging) is an official journal of the Korean Society of Nuclear Medicine, which bimonthly publishes papers on February, April, June, August, October, and December about nuclear medicine and related sciences such as radiochemistry, radiopharmacy, dosimetry and pharmacokinetics / pharmacodynamics of radiopharmaceuticals, nuclear and molecular imaging analysis, nuclear and molecular imaging instrumentation, radiation biology and radionuclide therapy. The journal specially welcomes works of artificial intelligence applied to nuclear medicine. The journal will also welcome original works relating to molecular imaging research such as the development of molecular imaging probes, reporter imaging assays, imaging cell trafficking, imaging endo(exo)genous gene expression, and imaging signal transduction. Nucl Med Mol Imaging publishes the following types of papers: original articles, reviews, case reports, editorials, interesting images, and letters to the editor.
The Korean Society of Nuclear Medicine (KSNM)
KSNM is a scientific and professional organization founded in 1961 and a member of the Korean Academy of Medical Sciences of the Korean Medical Association which was established by The Medical Services Law. The aims of KSNM are the promotion of nuclear medicine and cooperation of each member. The business of KSNM includes holding academic meetings and symposia, the publication of journals and books, planning and research of promoting science and health, and training and qualification of nuclear medicine specialists.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
