The Role of Serum Thyroglobulin Doubling Time in Predicting Recurrences/Metastasis on ¹⁸F-FDG PET/CT and Prognosis of Differentiated Thyroid Cancer Patients with High Thyroglobulin and Negative Whole-Body Radioactive Iodine Scintigraphy.

IF 2.7 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Nuclear Medicine and Molecular Imaging Pub Date : 2025-08-01 Epub Date: 2025-03-10 DOI:10.1007/s13139-025-00912-6

Nguyen Thi Phuong, Mai Hong Son, Nong Thanh Ha, Chu Khanh Linh, Le Ngoc Ha

{"title":"The Role of Serum Thyroglobulin Doubling Time in Predicting Recurrences/Metastasis on 18F-FDG PET/CT and Prognosis of Differentiated Thyroid Cancer Patients with High Thyroglobulin and Negative Whole-Body Radioactive Iodine Scintigraphy.","authors":"Nguyen Thi Phuong, Mai Hong Son, Nong Thanh Ha, Chu Khanh Linh, Le Ngoc Ha","doi":"10.1007/s13139-025-00912-6","DOIUrl":null,"url":null,"abstract":"Purpose: To evaluate the value of thyroglobulin doubling time (Tg-DT) in predicting 18F-FDG PET/CT findings and clinical outcomes in differentiated thyroid cancer (DTC) patients with high thyroglobulin (Tg) level and negative 131I whole-body scan (131I WBS).Materials and methods: 188 DTC patients with Tg levels ≥ 10 ng/ml and negative 131I WBS underwent 18F-FDG PET/CT scan. Three last consecutive values of unstimulated Tg were used to calculate Tg doubling time (Tg-DT). ROC curve analysis was performed to determine the optimal thresholds of Tg-DT in predicting 18F-FDG PET/CT results. Patients were followed up for at least 12 months after PET/CT scan. The Kaplan-Meier curve was used to estimate progression-free survival (PFS) and overall survival (OS). Cox regression analyses were conducted to identify factors significantly associated with PFS and OS.Results: The specificity and positive predictive value of Tg-DT for predicting 18F-FDG PET/CT findings were 93.94%, and 92.6%, respectively, while those for Tg levels were 78.79% and 83.53% (p < 0.001). This study revealed that stimulated Tg and Tg-DT can predict disease progression and survival in DTC patients. Age > 55, distant metastasis on 18F-FDG PET/CT, and Tg-DT ≤ 12 months were independent predictors of PFS. Distant metastasis and Tg-DT ≤ 12 months were independent prognostic factors for OS.Conclusion: Tg-DT is a valuable biomarker in predicting positive 18F-FDG PET/CT findings in DTC patients with high Tg level and negative 131I WBS. Along with distant metastases, Tg-DT ≤ 12 months is the only independent prognostic factor for PFS and OS.","PeriodicalId":19384,"journal":{"name":"Nuclear Medicine and Molecular Imaging","volume":"59 4","pages":"246-254"},"PeriodicalIF":2.7000,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267783/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nuclear Medicine and Molecular Imaging","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s13139-025-00912-6","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/3/10 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: To evaluate the value of thyroglobulin doubling time (Tg-DT) in predicting ¹⁸F-FDG PET/CT findings and clinical outcomes in differentiated thyroid cancer (DTC) patients with high thyroglobulin (Tg) level and negative ¹³¹I whole-body scan (¹³¹I WBS).

Materials and methods: 188 DTC patients with Tg levels ≥ 10 ng/ml and negative ¹³¹I WBS underwent ¹⁸F-FDG PET/CT scan. Three last consecutive values of unstimulated Tg were used to calculate Tg doubling time (Tg-DT). ROC curve analysis was performed to determine the optimal thresholds of Tg-DT in predicting ¹⁸F-FDG PET/CT results. Patients were followed up for at least 12 months after PET/CT scan. The Kaplan-Meier curve was used to estimate progression-free survival (PFS) and overall survival (OS). Cox regression analyses were conducted to identify factors significantly associated with PFS and OS.

Results: The specificity and positive predictive value of Tg-DT for predicting ¹⁸F-FDG PET/CT findings were 93.94%, and 92.6%, respectively, while those for Tg levels were 78.79% and 83.53% (p < 0.001). This study revealed that stimulated Tg and Tg-DT can predict disease progression and survival in DTC patients. Age > 55, distant metastasis on ¹⁸F-FDG PET/CT, and Tg-DT ≤ 12 months were independent predictors of PFS. Distant metastasis and Tg-DT ≤ 12 months were independent prognostic factors for OS.

Conclusion: Tg-DT is a valuable biomarker in predicting positive ¹⁸F-FDG PET/CT findings in DTC patients with high Tg level and negative ¹³¹I WBS. Along with distant metastases, Tg-DT ≤ 12 months is the only independent prognostic factor for PFS and OS.

查看原文本刊更多论文

血清甲状腺球蛋白翻倍时间对高甲状腺球蛋白、全身放射性碘显像阴性分化型甲状腺癌患者18F-FDG PET/CT预测复发/转移及预后的作用

目的：探讨甲状腺球蛋白倍增时间（Tg- dt）对高甲状腺球蛋白（Tg）水平、131I全身扫描（131I WBS）阴性分化型甲状腺癌（DTC）患者18F-FDG PET/CT表现及临床预后的预测价值。材料与方法：188例Tg水平≥10 ng/ml、131I WBS阴性的DTC患者行18F-FDG PET/CT扫描。最后三个连续的未受激Tg值被用来计算Tg倍增时间（Tg- dt）。采用ROC曲线分析确定Tg-DT预测18F-FDG PET/CT结果的最佳阈值。患者在PET/CT扫描后随访至少12个月。Kaplan-Meier曲线用于估计无进展生存期（PFS）和总生存期（OS）。Cox回归分析确定与PFS和OS显著相关的因素。结果：Tg- dt预测18F-FDG PET/CT表现的特异性和阳性预测值分别为93.94%和92.6%，Tg水平预测PFS的特异性和阳性预测值分别为78.79%和83.53% (p = 55)， 18F-FDG PET/CT远处转移和Tg- dt≤12个月是PFS的独立预测因子。远处转移和Tg-DT≤12个月是OS的独立预后因素。结论：Tg- dt是预测高Tg、131I WBS阴性DTC患者18F-FDG阳性PET/CT表现的有价值的生物标志物。随着远处转移，Tg-DT≤12个月是PFS和OS的唯一独立预后因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Nuclear Medicine and Molecular Imaging RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

CiteScore

2.20

自引率

7.70%

发文量

期刊介绍： Nuclear Medicine and Molecular Imaging (Nucl Med Mol Imaging) is an official journal of the Korean Society of Nuclear Medicine, which bimonthly publishes papers on February, April, June, August, October, and December about nuclear medicine and related sciences such as radiochemistry, radiopharmacy, dosimetry and pharmacokinetics / pharmacodynamics of radiopharmaceuticals, nuclear and molecular imaging analysis, nuclear and molecular imaging instrumentation, radiation biology and radionuclide therapy. The journal specially welcomes works of artificial intelligence applied to nuclear medicine. The journal will also welcome original works relating to molecular imaging research such as the development of molecular imaging probes, reporter imaging assays, imaging cell trafficking, imaging endo(exo)genous gene expression, and imaging signal transduction. Nucl Med Mol Imaging publishes the following types of papers: original articles, reviews, case reports, editorials, interesting images, and letters to the editor. The Korean Society of Nuclear Medicine (KSNM) KSNM is a scientific and professional organization founded in 1961 and a member of the Korean Academy of Medical Sciences of the Korean Medical Association which was established by The Medical Services Law. The aims of KSNM are the promotion of nuclear medicine and cooperation of each member. The business of KSNM includes holding academic meetings and symposia, the publication of journals and books, planning and research of promoting science and health, and training and qualification of nuclear medicine specialists.