Nuclear Medicine and Molecular Imaging最新文献

{"title":"⁶⁸Ga-DOTA-RGD₂ Uptake in Plantar Fasciitis: New Insights into its Pathogenesis.","authors":"Piyush Aggarwal,&nbsp;Harmandeep Singh,&nbsp;Rajender Kumar,&nbsp;Aman Sharma","doi":"10.1007/s13139-022-00743-9","DOIUrl":"https://doi.org/10.1007/s13139-022-00743-9","url":null,"abstract":"<p><p>Plantar fasciitis is chronic degenerative tendinopathy of the plantar fascia. Although it has many treatment modalities, none has been very effective due to the largely unknown pathogenesis of this condition. ⁶⁸Ga-DOTA-RGD₂ has an upcoming role in assessing disease activity and treatment response in rheumatoid arthritis. In the present case, we demonstrate the potential role of angiogenesis imaging in understanding the pathogenesis of plantar fasciitis and provide new opportunities for novel imaging options.</p>","PeriodicalId":19384,"journal":{"name":"Nuclear Medicine and Molecular Imaging","volume":"56 3","pages":"169-170"},"PeriodicalIF":1.3,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9123142/pdf/13139_2022_Article_743.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9556591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"KSNM 60 in General Nuclear Medicine: the Old Dream Comes True.","authors":"Won Woo Lee,&nbsp;Jin-Sook Ryu","doi":"10.1007/s13139-021-00731-5","DOIUrl":"https://doi.org/10.1007/s13139-021-00731-5","url":null,"abstract":"<p><p>Since the establishment of the Korean Society of Nuclear Medicine (KSNM) in 1961 by Professor Munho Lee, the KSNM has been progressing in various medical fields. Many papers have been published in the Korean Journal of Nuclear Medicine (KJNM), the official journal of KSNM, since 1967 and other domestic/international journals. Here, we tried to highlight the academic activities of KSNM members from the perspective of general nuclear medicine. After the introduction of the ⁹⁹Mo/^99mTc generator, general nuclear medicine has widened the field of clinical application with the advancement of imaging technology and emerging new radiopharmaceuticals; however, there have been many ups and downs. Treatment, as well as diagnosis, was a major concern in Korean nuclear medicine. With the recent advent of single-photon emission computed tomography/computed tomography, we hope that our old dream (diagnosis and treatment under the same principle of nuclear medicine) comes true.</p>","PeriodicalId":19384,"journal":{"name":"Nuclear Medicine and Molecular Imaging","volume":"56 2","pages":"71-79"},"PeriodicalIF":1.3,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8976866/pdf/13139_2021_Article_731.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9226857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[68 Ga]Ga-PSMA-11 Small Bowel Uptake in Crohn's Disease: Revisiting the \"Non-specificity\" of PSMA Ligands.","authors":"Kunal Ramesh Chandekar,&nbsp;Sindhu Tanigassalam,&nbsp;Anwin Joseph Kavanal,&nbsp;Harmandeep Singh,&nbsp;Anish Bhattacharya,&nbsp;Ravimohan Suryanarayan Mavuduru","doi":"10.1007/s13139-021-00732-4","DOIUrl":"https://doi.org/10.1007/s13139-021-00732-4","url":null,"abstract":"<p><p>The rapidly evolving clinical utility of prostate-specific membrane antigen (PSMA) PET/CT as an imaging modality for prostate cancer (PCa) has brought to the forefront a multitude of non-prostatic diseases also exhibiting PSMA radioligand uptake. We report a case of a 71-year-old male with PCa who underwent PSMA PET/CT for recurrence evaluation. The scan demonstrated [68 Ga]Ga-PSMA-11 uptake in the distal ileum. Retrospective enquiry revealed that the patient was a known case of Crohn's disease. This case highlights an uncommon finding of PSMA radioligand uptake in the distal small bowel (non-prostatic benign pathological uptake) in a patient with known Crohn's disease, which may be misinterpreted in the evaluation of PCa.</p>","PeriodicalId":19384,"journal":{"name":"Nuclear Medicine and Molecular Imaging","volume":"56 2","pages":"102-104"},"PeriodicalIF":1.3,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8976716/pdf/13139_2021_Article_732.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9226859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent Advances in Cancer Imaging with ⁶⁴CuCl₂ PET/CT.","authors":"Fangyu Peng","doi":"10.1007/s13139-022-00738-6","DOIUrl":"https://doi.org/10.1007/s13139-022-00738-6","url":null,"abstract":"<p><p><i>Copper</i> is required for cancer cell proliferation and tumor angiogenesis. Radioactive copper-64 chloride (⁶⁴CuCl₂) is a useful radiotracer for cancer imaging with position emission tomography (PET) based on increased cellular uptake of copper mediated by human copper transporter 1 (hCtr1) expressed on cancer cell membrane. Significant progress has been made in research of using ⁶⁴CuCl₂ as a radiotracer for cancer imaging with PET. Radiation dosimetry study in humans demonstrated radiation safety of ⁶⁴CuCl₂. Recently, ⁶⁴CuCl₂ was successfully used for PET imaging of prostate cancer, bladder cancer, glioblastoma multiforme (GBM), and non-small cell lung carcinoma in humans. Based on the findings from the preclinical research studies, ⁶⁴CuCl₂ PET/CT also holds potential for diagnostic imaging of human hepatocellular carcinoma (HCC), malignant melanoma, and detection of intracranial metastasis of copper-avid tumors based on low physiological background of radioactive copper uptake in the brain. Copper-64 radionuclide emits both β⁺ and β^- particles, suggesting therapeutic potential of ⁶⁴CuCl₂ for radionuclide cancer therapy of copper-avid tumors. Recent progress in production of therapeutic copper-67 radionuclide invites clinical research in use of theranostic pair of ⁶⁴CuCl₂ and ⁶⁷CuCl₂ for cancer imaging and radionuclide therapy.</p>","PeriodicalId":19384,"journal":{"name":"Nuclear Medicine and Molecular Imaging","volume":"56 2","pages":"80-85"},"PeriodicalIF":1.3,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8976861/pdf/13139_2022_Article_738.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9226860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Bone Scan Is Valuable for Primary Staging of Newly Diagnosed Prostate Cancer in a Low-Resource Setting (Nigeria).","authors":"Akintunde T Orunmuyi,&nbsp;Sikiru A Adebayo,&nbsp;Olayinka S Ilesanmi,&nbsp;Augustine O Takure,&nbsp;E Oluwabunmi Olapade-Olaopa","doi":"10.1007/s13139-021-00735-1","DOIUrl":"https://doi.org/10.1007/s13139-021-00735-1","url":null,"abstract":"<p><strong>Objective: </strong>There is a paucity of information on bone scanning for prostate cancer from low-resource countries. This study evaluated the role of bone scan in the primary staging of newly diagnosed prostate cancer in one such setting.</p><p><strong>Methods: </strong>A retrospective analysis of 126 men with newly diagnosed prostate cancer undergoing an initial staging bone scan between January 2017 and December 2020 was carried out at a regional nuclear medicine center in Nigeria. Bone scan results were analyzed according to age, serum level of baseline prostate-specific antigen (PSA), and Gleason score. Equivocal scans and patients with no Gleason score or baseline PSA were excluded from the analysis. <i>p</i> < 0.05 was said to be significant statistically.</p><p><strong>Results: </strong>Of 111 patients (aged 38-84 years, median 66 years), who met the inclusion criteria, 26 (23%) men had evidence of bony metastases as shown by a positive bone scan. Higher PSA levels and Gleason scores were associated with an increased risk of a positive bone scan, <i>p</i> < 0.001. No patient with a PSA level < 20 ng/mL and a Gleason score of < 7 had a positive bone scan.</p><p><strong>Conclusion: </strong>The role of bone scanning in staging newly diagnosed prostate cancer patients in Nigeria is consistent with global reports. Our study confirms that a bone scan finding is well associated with the risk classification using PSA and Gleason score in our population.</p>","PeriodicalId":19384,"journal":{"name":"Nuclear Medicine and Molecular Imaging","volume":"56 2","pages":"96-101"},"PeriodicalIF":1.3,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8976715/pdf/13139_2021_Article_735.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9226861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of the Estrogen Receptor Status of Leptomeningeal Metastasis in Patients with Metastatic Breast Cancer Using [¹⁸F]-FES PET/CT: a Case Report.","authors":"Jeongryul Ryu,&nbsp;Jae Ho Jeong,&nbsp;Dae Hyuk Moon,&nbsp;Dong Yun Lee","doi":"10.1007/s13139-022-00736-8","DOIUrl":"https://doi.org/10.1007/s13139-022-00736-8","url":null,"abstract":"<p><p>Accurate determination of the hormone receptor status in patients with breast cancer is necessary to provide better palliative treatment because of the frequent discordant status of hormone receptors between primary breast cancer and metastatic lesions. In particular, the invasive nature and small number of cells recovered from the cerebrospinal fluid collected through lumbar puncture limit the detailed immunocytochemistry investigation of leptomeningeal metastasis. Moreover, none of the conventional imaging modalities provide any information on the hormone receptor status of leptomeningeal metastasis in patients with breast cancer. Herein, we report estrogen receptor-positive leptomeningeal metastasis clearly demonstrated by 16α-[¹⁸F]-fluoro-17β-estradiol ([¹⁸F]-FES) positron emission tomography/computed tomography (PET/CT) in a patient with metastatic breast cancer.</p>","PeriodicalId":19384,"journal":{"name":"Nuclear Medicine and Molecular Imaging","volume":"56 2","pages":"105-109"},"PeriodicalIF":1.3,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8976712/pdf/13139_2022_Article_736.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9226858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In the COVID-19 Era, Is It OK to Perform a Perfusion-Only SPECT/CT for the Diagnosis of Pulmonary Embolism?","authors":"M. Suh","doi":"10.1007/s13139-022-00740-y","DOIUrl":"https://doi.org/10.1007/s13139-022-00740-y","url":null,"abstract":"","PeriodicalId":19384,"journal":{"name":"Nuclear Medicine and Molecular Imaging","volume":"56 1","pages":"67 - 70"},"PeriodicalIF":1.3,"publicationDate":"2022-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47188828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improved Stability and Practicality for Synthesis of 4-Borono-2-[18F]fluoro-l-phenylalanine by Combination of [18O]O2 Single-Use and [18F]CH3COOF Labeling Agents","authors":"Sadahiro Naka, Toshimitsu Watanabe, Y. Kanai, T. Watabe, M. Tatsumi, H. Kato, E. Shimosegawa, J. Hatazawa","doi":"10.1007/s13139-021-00719-1","DOIUrl":"https://doi.org/10.1007/s13139-021-00719-1","url":null,"abstract":"","PeriodicalId":19384,"journal":{"name":"Nuclear Medicine and Molecular Imaging","volume":"56 1","pages":"86 - 95"},"PeriodicalIF":1.3,"publicationDate":"2022-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43000287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"68Ga-PSMA-11 uptake in tracheal mucus plug - a potential pitfall.","authors":"Kunal Ramesh Chandekar,&nbsp;Apurva Sood,&nbsp;Rajender Kumar,&nbsp;Harmandeep Singh,&nbsp;Shrawan Kumar Singh","doi":"10.1007/s13139-021-00729-z","DOIUrl":"https://doi.org/10.1007/s13139-021-00729-z","url":null,"abstract":"<p><p>Prostate-specific membrane antigen (PSMA) PET/CT is a well-acclaimed imaging modality for prostate cancer (PCa). However, many reports have highlighted PSMA radioligand uptake in a variety of benign tumors and lesions. We report a case of PCa in which ⁶⁸ Ga-PSMA-11 uptake was noted in the tracheal lumen. However, ¹⁸F-PSMA-1007 PET/CT was done on a subsequent day, which demonstrated no abnormal radiotracer uptake or morphological lesion within the tracheal lumen. This case highlights an uncommon finding of PSMA ligand uptake in a tracheal mucus plug (non-prostatic benign uptake), which may be misinterpreted as a false-positive finding.</p>","PeriodicalId":19384,"journal":{"name":"Nuclear Medicine and Molecular Imaging","volume":"56 1","pages":"63-66"},"PeriodicalIF":1.3,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8828821/pdf/13139_2021_Article_729.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9164364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of ^99mTc Pertechnetate Thyroid Uptake Rates by Gamma Probe and Gamma Camera Methods for Differentiating Graves' Disease and Thyroiditis.","authors":"Meihua Jin,&nbsp;Jonghwa Ahn,&nbsp;Seong-Gil Jo,&nbsp;Jangwon Park,&nbsp;Min Ji Jeon,&nbsp;Won Gu Kim,&nbsp;Tae Yong Kim,&nbsp;Won Bae Kim,&nbsp;Young Kee Shong,&nbsp;Jin-Sook Ryu","doi":"10.1007/s13139-021-00734-2","DOIUrl":"https://doi.org/10.1007/s13139-021-00734-2","url":null,"abstract":"<p><strong>Background: </strong>Technetium-99 m (^99mTc) pertechnetate thyroid uptake rate can be measured with a gamma probe or gamma camera. This study was performed to compare their diagnostic accuracy for evaluating patients with thyrotoxicosis.</p><p><strong>Methods: </strong>We retrospectively reviewed ^99mTc pertechnetate thyroid uptake rate records of patients by both gamma probe and camera methods at a tertiary center in Korea from November 2019 to June 2020. We determined the normal reference ranges of thyroid uptake rate by two methods and compared both methods for differentiating Graves' disease and thyroiditis in patients with thyrotoxicosis by receiver operating characteristic curve analysis.</p><p><strong>Results: </strong>A total of 371 patients (euthyroid 89, Graves 167, and thyroiditis 115) were included. The normal reference range for thyroid uptake rate in euthyroid patients was 0.3-1.9% and 2.0-4.7% for the camera and probe methods, respectively. For differentiating Graves' disease and thyroiditis, the area under the curve of the camera method (0.988) was significantly greater than that (0.975) of the probe method (<i>p</i> = 0.030). The sensitivity and specificity for the probe method were 92.2% and 91.3%, respectively, with a cut-off value of 3.0%. Those for the camera method were 93.4% and 94.8%, respectively, with a cut-off value of 0.7%.</p><p><strong>Conclusion: </strong>^99mTc pertechnetate thyroid uptake rate measured by the camera method had higher diagnostic accuracy than the probe method for evaluating patients with thyrotoxicosis. Considering the diagnostic accuracy and patient convenience, the thyroid uptake rate measured by the camera method would be a good substitute for the probe method.</p>","PeriodicalId":19384,"journal":{"name":"Nuclear Medicine and Molecular Imaging","volume":"56 1","pages":"42-51"},"PeriodicalIF":1.3,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8828838/pdf/13139_2021_Article_734.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10595517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}