Novelty in Biomedicine最新文献

{"title":"Comparison of The Effect of Intra-Articular Injection of Autologous (Orthokine) Interleukin-1 (IL-1Ra) Receptor Antagonist and Hyaluronic Acid in Pain Control of Knee Osteoarthritis","authors":"M. Hashemi, M. Taheri, Hossein Adlkhoo, Payman Dadkhah, M. Abbasian","doi":"10.22037/NBM.V7I3.25121","DOIUrl":"https://doi.org/10.22037/NBM.V7I3.25121","url":null,"abstract":"Background: Due to the limitations of more common treatments of osteoarthritis, pharmaceutical research has been increasingly conducted during the past two decades with the aim of determining the rate of recovery of the disease' symptoms and making the process of disease progression slow. The purpose of this study was to compare the effect of intra-articular injection of autologous interleukin-1 Receptor Antagonist and hyaluronic acid in pain control of knee osteoarthritis. M aterials and Methods: A total of 60 patients with knee osteoarthritis were allocated to two groups of 30 in this randomized double-blind clinical trial. In the intervention group, injection of 2 milliliter of interleukin-1 receptor antagonist (Orthokine) into the knee joint was performed three times at intervals of one week (base time, seventh day and fourteenth day). In the control group, three injections of two milliliters of hyaluronic acid solution into the knee joint were performed at intervals of one week. Pain, symptoms, daily activities, sport-recreational performance, and knee-related quality of life were five outcomes investigated by completing two questionnaires, the knee injury and osteoarthritis outcome score (KOOS), Western Ontario, and McMaster Universities Arthritis Index (WOMAC) by the patients on two occasions before the start of treatment and six months after the last injection. Repeated measure and t-test were statistical tests used in this study. R es ults: The mean score of pain in the first month (p=0.005) and the sixth (p=0.049) in the intervention group was less than the control group. Based on the scores of the KOOS questionnaire, the mean score of symptoms (p=0.006), daily activities (p=0.001) and sport-recreational performance (p=0.037) in the Orthokine group were higher than the hyaluronic acid group after six months. Also, the results of the questionnaire WOMAC show that while before the start of treatment, the mean of physical performance in the Orthokine group is greater than the control group, there is no difference in any of the indicators of pain, dryness of the joint, physical performance, and total score (p=0.319) in the sixth month. C onclusion: According to the findings of this study, it seems that Orthokine has beneficial biological effects in patients with knee osteoarthritis. Intra-articular injection of Orthokine is a low invasive, safe and effective method, which can be considered as an appropriate choice in patients with chronic knee pain.","PeriodicalId":19372,"journal":{"name":"Novelty in Biomedicine","volume":"2 1","pages":"210-217"},"PeriodicalIF":0.0,"publicationDate":"2019-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89260234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The explanation and effectiveness of intellectual and behavioral components in satisfying the lives of married women","authors":"Akram Ghashghayi, K. Farahbaksh, Asieh Shariatmadar, A. Moatamedi","doi":"10.22037/NBM.V7I3.24673","DOIUrl":"https://doi.org/10.22037/NBM.V7I3.24673","url":null,"abstract":"Background: The aim of this study was to determine the components of the educational model of intellectual and behavioral principles in healthy interpersonal relationships based on the Holy Quran and its effectiveness on marital satisfaction of married women. Research was arranged in two sections. Materials and Methods: The research method was qualitative in the first part and was quantitative in the second part. In the qualitative section, after researching and searching in the sources of the Quran, which was carried out by a qualitative method in the form of thematic analysis, ultimately the intellectual and practical principles in the healthy interpersonal relations based on the Holy Quran were determined and explained. The method of the second part of the research is quantitative and of type Semi-experimental, with pre-test-posttest design with control group and random selection. For this purpose, 30 married women with children from Tehran selected in a sample of 30-97 years old and randomly assigned to two groups of 15 subjects. The instrument of this research was a survival satisfaction questionnaire (SWIS). The experimental group was placed under the training of the principles of intellectual and behavioral training in healthy interpersonal relationships based on the Holy Qur'an for two months. Results: The results of the hypothesis test showed that the components of the educational model of intellectual and behavioral principles in healthy interpersonal relationships based on the Holy Quran On the other hand, life satisfaction variable (83.36, F=0.001) had a significant effect. This power is 100%. In other words, there was a significant difference between the experimental group and the control group in terms of the variables. Conclusion: In explaining this finding, it could be said that the sacred religion of Islam in various aspects of family life has provided useful commands and teachings. In Islamic religion, marriage and family are declared the most beloved and dearest human institution to God, and the adoption of these orders can affect the satisfaction of couple’s life.","PeriodicalId":19372,"journal":{"name":"Novelty in Biomedicine","volume":"48 1","pages":"225-231"},"PeriodicalIF":0.0,"publicationDate":"2019-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89817943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cause-Specific Mortality among HIV-Infected Persons in One Medical Center, Tehran, Iran","authors":"Zahra Arab-Mazar, Fahimeh Hadavand, P. Tabarsi, F. Abbasi","doi":"10.22037/NBM.V7I3.24278","DOIUrl":"https://doi.org/10.22037/NBM.V7I3.24278","url":null,"abstract":"Background: Human immunodeficiency virus (HIV) is one of the major infectious agents, which has important role in the public health challenges, which have affected the world's economic and social situation recent decades. During the last decades, millions of people died due to HIV infection worldwide. However, data remain limited on the causes of death among HIV-infected in Iranian population. The aim of the present study was to assess the cause specific death among HIV positive inpatient persons in Iran. M aterials and Methods: This surveillance was conducted on inpatient HIV positive admissions at Masih Daneshvari Hospital, Tehran, Iran during October 2016 and April 2017.All patient’s data were collected via abstraction form, which were ascertained, from medical records and from written logbooks that were kept by the nursing staff on the ward. The data of each admission was recorded from the medical reports at the time of admission and upon discharge. All laboratory data were collected and recorded separately. R es ults: Fifty persons were diagnosed as HIV-infected patients, of which 58% of them were classified as AIDS patients. Our findings indicated that the cause of hospitalization were pulmonary 54%, neurological 20%, gastrointestinal 16%, and dermal 10% complications. Overall, 21 patients (42%) were diagnosed with pulmonary tuberculosis, of which one patient died from tuberculosis complications. Four patients died during the study period. C onclusion: In conclusion, early treatment and/or early use of ART can be improved outcomes. Therefore, early HIV testing and early ART use play important role in mortality reduction among eligible persons.","PeriodicalId":19372,"journal":{"name":"Novelty in Biomedicine","volume":"41 1","pages":"254-259"},"PeriodicalIF":0.0,"publicationDate":"2019-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77560110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of ankle sprain on postural control and electrical activity of selected muscles after single-leg jump landing task","authors":"B. Maleki, Zahed Mantashloo, Shahin Salehi, Amir Hosein Abedi Yekta","doi":"10.22037/NBM.V7I3.24860","DOIUrl":"https://doi.org/10.22037/NBM.V7I3.24860","url":null,"abstract":"Background: Ankle joint plays an important role in restoring the balance of individuals. Ankle sprain injury effects on balance of affected individuals. The changes in the postural control and activity of the ankle muscle, because of ankle sprain, can put the patients at reinjure risk and lower extremity injuries, especially during dynamic activities. The aim of this study was to investigate the electrical activity of ankle joint stabilizer muscles and postural stability after single-leg jump landing in individuals with ankle sprain. M aterials and Methods: In this cross-sectional study, 30 non-athletic students were participated. They were divided in two groups of 15 people, in the form of accessible and purposeful. Subjects was asked to land on a force plate with Single-leg, by at least 80% of their maximum jump. The com-cop changes assessment was used as an indicator for postural control evaluation. After jump landing, muscles activity was recorded on the ankle joint by surface electromyography (EMG) device. MATLAB software was used to analyze data, and MANOVA test was performed to compare two groups. R es ults: The results showed a significant reduction in EMG of soleus, gastrocnemius, and peroneus longus muscles (p=0.03, p=0.01 and p=0.006 respectively). Tibialis anterior activity significantly increased (p=0.001) in patient group than to healthy group. Postural control was significantly lower in patient group than healthy group, in all directions (p=0.00 and p=0.00 respectively). C onclusion: Decreased postural control indicates changes in EMG of the stabilizer muscles of this joint in people with ankle sprain injury.","PeriodicalId":19372,"journal":{"name":"Novelty in Biomedicine","volume":"1 1","pages":"218-224"},"PeriodicalIF":0.0,"publicationDate":"2019-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88914761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the Effect of Melatonin on Pain Control and Quality of Life in Patients with Chronic Low Back Pain: A Randomized Clinical Trial","authors":"M. Hashemi, Payman Dadkhah, M. Taheri, M. Ghasemi","doi":"10.22037/NBM.V7I3.23691","DOIUrl":"https://doi.org/10.22037/NBM.V7I3.23691","url":null,"abstract":"Background: Almost everyone experiences low back pain at some point in his or her lives. Low back pain is becoming more prevalent in low-income and middle-income countries much more rapidly than in high-income countries. The objective of this study was to evaluate the effect of melatonin on pain control and quality of life in patients with chronic low back pain. M aterials and Methods: Sixty patients with low back pain aged 45 and 75 years, with a history of back pain more for than 12 weeks and visual analogue scale (VAS) score more than three, who were referred to pain clinics of Akhtar Hospitals (Tehran, Iran) during June to August 2018. Patients were randomly assigned to one of the melatonin or control groups. Control group received diclofenac sodium 25mg tablet two or three times daily and the experimental or melatonin group, in addition to receiving diclofenac sodium 25mg tablet twice a day, received melatonin tablet (3mg) 30 to 40 minutes before bedtime for four weeks. Before the beginning of the study, at the end of the fourth week, both groups underwent VAS test and the levels of IL-1β and TNF-α were measured in these groups and they were asked to complete the quality of life questionnaire. Analysis of the data done by using covariance and Shapiro-Wilk tests through SPSS 22. R es ults: Melatonin consumption reduced the pain and level of IL-1β and TNF-α in the experimental group compared to the control group (p 0.05). C onclusion: In general, it can be stated that use of melatonin, in addition to reducing the pain, reduces the anti-inflammatory factors in patients with chronic low back pain. Based on the results of this study, melatonin can be recommended as a supplement for treatment of chronic low back pain.","PeriodicalId":19372,"journal":{"name":"Novelty in Biomedicine","volume":"25 1","pages":"134-141"},"PeriodicalIF":0.0,"publicationDate":"2019-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74575658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytotoxic activity of Rosa damascene mill, Alliumsativum, Allium hirtifolium Boiss, and Prosopis farcta extracts on human cervical carcinoma cell line","authors":"E. Khadem, E. Faghihloo, T. Mokhtari-azad, M. Kamalinejad, K. razavi, M. Norouzi","doi":"10.22037/NBM.V7I3.24373","DOIUrl":"https://doi.org/10.22037/NBM.V7I3.24373","url":null,"abstract":"Background: Cervical cancer is one of the major reasons of cancer-related mortality. Human papillomavirus is the most common sexually transmitted viral infection, which can lead to cervical cancer. There is no powerful chemotherapeutic agent for HPV infection and cervical cancer. Some plants have the proper potential to be used for treatment of cervical cancer caused by HPV type 18. Materials and Methods: In this study, cytotoxic effect of extract of four indigenous Iranian plants including Rosa damascene mill, Allium sativum, Allium hirtifolium boiss and Prosopis farcta were investigated on the HeLa cell line. HeLa cells were incubated with different concentrations of extracts and then the cell viability was measured by MTT assay. Results: The viable cell numbers were decreased by increase of the extracts concentration. The Allium sativum showed the higher cytotoxicity in all concentrations than the other ones. Afterwards, Allium hirtifolium Boiss, Rosa damascene mill, and Prosopis farcta showed maximum efficiency to decrease cell viability, respectively. Conclusion: The above four mentioned plants might be used for death of HeLa cell harboring HPV type 18. Therefore, they could be employed as a chemotherapeutic agent in the cervical cancer treatment in future.","PeriodicalId":19372,"journal":{"name":"Novelty in Biomedicine","volume":"9 1","pages":"232-236"},"PeriodicalIF":0.0,"publicationDate":"2019-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78090372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comparative Study of Anxiety and Depression in Patient Undergoing Assisted Reproductive Technology with Donated Oocyte in Comparison with autologous oocyte in Infertile Women","authors":"Zahra Haidari, Masoumeh Mirzamoradi, Maryam Soleymannezhad","doi":"10.22037/NBM.V7I3.23764","DOIUrl":"https://doi.org/10.22037/NBM.V7I3.23764","url":null,"abstract":"Background: Since healthy psychological condition, influence the quality of life and social function. Infertility can be one of the stressful situation for every human. Therefore, in this study we assessed some psychological factors such as stress and depression in women who are candidates for taking ART with donated oocytes or autologous oocytes. M aterials and Methods: This cross sectional study was done in Tehran, Mahdieh hospital, during the 2016-2017. Patients who came one day before replacement of embryos, filled Beck and STAI questionnaires and their demographic information. R es ults: The incidence of severe degrees of depression and state anxiety and trait anxiety in patients treated by donated oocytes is more in patients who treated by autologous oocytes. C onclusion: Psychological situation was worse in patients treated by donated oocytes.","PeriodicalId":19372,"journal":{"name":"Novelty in Biomedicine","volume":"9 1","pages":"142-146"},"PeriodicalIF":0.0,"publicationDate":"2019-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85871073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of Effect of Platelet Rich Plasma Injection on Improving Pain and Function in Young Healthy Athletes with Isolated Grade 2 or 3 Knee Medial Collateral Ligament Sprains","authors":"Farzad Sharaki, M. P. Esfahani, M. Sajjadi, Shahin Salehi, A. A. Yekta, Mohamad Hasabi","doi":"10.22037/NBM.V7I3.23862","DOIUrl":"https://doi.org/10.22037/NBM.V7I3.23862","url":null,"abstract":"Background: Knee medial collateral ligament (MCL) sprain is common in athletes, which keeps them away from trainings. Platelet-rich plasma (PRP) injection is used as an adjunct for treatment of musculoskeletal injuries. This study was supposed to define effect of PRP injection on high-grade MCL sprain healing, in comparison to rehabilitation alone. M aterials and Methods: This study was performed on 46 healthy athletes with high-grade MCL sprains who came to sports medicine clinic of Taleghani Hospital, Tehran over a one-year period (2017-2018). In first visit injury grade, its location, baseline pain, Lysholm score and joint stability was determined. Participants randomly allocated to 2 groups (n=23), “group A” had 12-week functional rehabilitation and “group B” had the same rehabilitation plus a single PRP injection. At 4-week intervals valgus stress testing, pain and Lysholm scores was reassessed. The scores of 4 th , 8 th and 12 th weeks was compared to the baseline scores. R es ults: Mean baseline pain score in control and intervention group was 5.09±0.949 and 5.26±0.810 respectively that in the fourth week of study reduced to 1.30±0.765 and 2.43±0.507 (p<0.001). In intervention group, fourth week pain was significantly reduced while stability and Lysholm scores of the groups had no significant difference. C onclusion: PRP injection had a short-term statistically significant pain reduction effect that may assist in faster rehabilitation progress, shorter return to play and less detraining which is crucial to professional athletes.","PeriodicalId":19372,"journal":{"name":"Novelty in Biomedicine","volume":"21 1","pages":"147-157"},"PeriodicalIF":0.0,"publicationDate":"2019-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89339116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the effectiveness of cognitive behavioral stress management (CBSM) on pain perception of cancer patients","authors":"Ali Asadbeygi, H. Ahadi, H. Mirzaei","doi":"10.22037/NBM.V7I2.24272","DOIUrl":"https://doi.org/10.22037/NBM.V7I2.24272","url":null,"abstract":"Background: Disease-related cancer pain is a multidimensional phenomenon. Psychological factors that may alter pain perception in cancer patients have not been well studied. The purpose of this study was to determine the effectiveness of cognitive-behavioral stress therapy on distress in patients with cancer. Patients and Methods: In a cross-sectional study of consecutive patients (32-70 years ) , progression of their disease was at levels 1 to 3, high cycle education, and 3 months of chemotherapy, of which 40 were randomly available to the study and allocated to two groups (20 in experimental and 20 in control groups). The instrument was a McGill pain questionnaire (1997). Data were analyzed using two methods of Kolmogorov-Smirnov inferential statistics and multivariate analysis of covariance using SPSS Ver.17. R es ults: Correlation analysis showed that the experimental group had a significant reduction in perception of pain, in the posttest after the experiment compared with the control group. C onclusion: The short-term cognitive-behavioral stress management program could reduce the perception of pain in cancer patients.","PeriodicalId":19372,"journal":{"name":"Novelty in Biomedicine","volume":"49 1","pages":"130-133"},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83661235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fabrication and Characterization of Covalently Functionalized poly Caprolactone Scaffold for Bone Tissue Engineering Application","authors":"N. Sadeghzade, M. Nouri, A. Nateri, M. Soleimani","doi":"10.22037/NBM.V7I2.22015","DOIUrl":"https://doi.org/10.22037/NBM.V7I2.22015","url":null,"abstract":"Background: Healing bone involves osteoconductive and osteoinductive components as well as a scaffold with adequate porosity to allow good cell infiltration. M aterials and Methods: Herein, cytocompatibility and osteogenic induction potential of polycaprolactone (PCL) nanofibrous electrospun scaffold with different electron microscopy, MTT assay, DAPI and alizarin porosities (35%-90%) and chemical bonding was assessed through scanning red S staining, calcium content and alkaline phosphatase assay. Moreover, the relative expression of three important osteogenic-related genes Col I, RUNX 2 and osteocalcin was studied. R es ults: Covalent bonding played a more significant osteogenic role in scaffolds in scaffolds with lower porosity, namely H35cov. Although low porosity limits cell infiltration, substrate with lower porosities were easier to handle. On the other hand, substrates with higher porosity showed higher levels of cell proliferation, mineralization as well as osteogenic differentiation. C onclusion: Results indicated that PCL scaffold with higher porosity degree up to 90%, covalently functionalized by collagen, and hydroxyapatite nanoparticles was a good candidate for bone tissue engineering applications.","PeriodicalId":19372,"journal":{"name":"Novelty in Biomedicine","volume":"78 1","pages":"101-113"},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80837532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}