Nitric oxide : biology and chemistry最新文献_第9页

Applications of nitric oxide-releasing nanomaterials in dermatology: Skin infections and wound healing 一氧化氮释放纳米材料在皮肤病学中的应用：皮肤感染和伤口愈合。

IF 3.9 2区生物学

Nitric oxide : biology and chemistry Pub Date : 2024-03-06 DOI: 10.1016/j.niox.2024.03.001

Sara Abdel Azim , Cleo Whiting , Adam J. Friedman

引用次数: 0

Exhaled nitric oxide levels in COPD patients who use electronic cigarettes 使用电子香烟的慢性阻塞性肺病患者呼出的一氧化氮水平。

IF 3.9 2区生物学

Nitric oxide : biology and chemistry Pub Date : 2024-02-29 DOI: 10.1016/j.niox.2024.02.006

Andrew Higham , Augusta Beech , Dave Singh

{"title":"Exhaled nitric oxide levels in COPD patients who use electronic cigarettes","authors":"Andrew Higham , Augusta Beech , Dave Singh","doi":"10.1016/j.niox.2024.02.006","DOIUrl":"10.1016/j.niox.2024.02.006","url":null,"abstract":"<div><p>Emerging data from clinical studies have shown pro-inflammatory effects associated with e-cigarette use. Fractional exhaled nitric oxide (FeNO) is a biomarker of pulmonary type 2 (T2) inflammation. The effect of chronic e-cigarette use on FeNO is unclear. The aim of this study was to compare FeNO levels in COPD ex-smokers who use e-cigarettes (COPDE + e-cig) to COPDE ex-smokers (COPDE) and COPD current smokers (COPDS). FeNO levels were significantly higher in COPDE + e-cig (median 16.2 ppb) and COPDE (median 18.0 ppb) compared to COPDS (median 7.6 ppb) (p = 0.0003 and p < 0.0001 respectively). There was no difference in FeNO levels between COPDE + e-cig compared to COPDE (p > 0.9). The importance of our results is that electronic cigarette use does not alter the interpretation of FeNO results, and so does not interfere with the use of FeNO as a practical biomarker of T2 inflammation, unlike current cigarette smoking in COPD. Whilst the effect of electronic cigarette use on FeNO levels is not the same as cigarette smoke, this cannot be taken as evidence that electronic cigarettes are harmless. These differential pulmonary effects can be attributed to differences in the chemical composition of the two products.</p></div>","PeriodicalId":19357,"journal":{"name":"Nitric oxide : biology and chemistry","volume":"145 ","pages":"Pages 57-59"},"PeriodicalIF":3.9,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1089860324000296/pdfft?md5=47679fc43d04ec0dac9bd4f2cc5a3767&pid=1-s2.0-S1089860324000296-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140013092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cannabidiol induces systemic analgesia through activation of the PI3Kγ/nNOS/NO/KATP signaling pathway in neuropathic mice. A KATP channel S-nitrosylation-dependent mechanism 大麻二酚通过激活神经病理性小鼠的 PI3Kγ/nNOS/NO/KATP 信号通路诱导全身镇痛。KATP通道S-亚硝基依赖机制。

IF 3.9 2区生物学

Nitric oxide : biology and chemistry Pub Date : 2024-02-29 DOI: 10.1016/j.niox.2024.02.005

Douglas Lamounier de Almeida , Renata Cristina Mendes Ferreira , Flávia Cristina Fonseca , Daniel Portela Dias Machado , Danielle Diniz Aguiar , Francisco Silveira Guimaraes , Igor Dimitri Gama Duarte , Thiago Roberto Lima Romero

{"title":"Cannabidiol induces systemic analgesia through activation of the PI3Kγ/nNOS/NO/KATP signaling pathway in neuropathic mice. A KATP channel S-nitrosylation-dependent mechanism","authors":"Douglas Lamounier de Almeida , Renata Cristina Mendes Ferreira , Flávia Cristina Fonseca , Daniel Portela Dias Machado , Danielle Diniz Aguiar , Francisco Silveira Guimaraes , Igor Dimitri Gama Duarte , Thiago Roberto Lima Romero","doi":"10.1016/j.niox.2024.02.005","DOIUrl":"10.1016/j.niox.2024.02.005","url":null,"abstract":"<div><h3>Background</h3><p>Cannabidiol (CBD) is the second most abundant pharmacologically active component present in Cannabis sp. Unlike Δ-9-tetrahydrocannabinol (THC), it has no psychotomimetic effects and has recently received significant interest from the scientific community due to its potential to treat anxiety and epilepsy. CBD has excellent anti-inflammatory potential and can be used to treat some types of inflammatory and neuropathic pain. In this context, the present study aimed to evaluate the analgesic mechanism of cannabidiol administered systemically for the treatment of neuropathic pain and determine the endogenous mechanisms involved with this analgesia. Methods: Neuropathic pain was induced by sciatic nerve constriction surgery, and the nociceptive threshold was measured using the paw compression test in mice. Results: CBD produced dose-dependent antinociception after intraperitoneal injection. Selective inhibition of PI3Kγ dose-dependently reversed CBD-induced antinociception. Selective inhibition of nNOS enzymes reversed the antinociception induced by CBD, while selective inhibition of iNOS and eNOS did not alter this antinociception. However, the inhibition of cGMP production by guanylyl cyclase did not alter CBD-mediated antinociception, but selective blockade of ATP-sensitive K+ channels dose-dependently reversed CBD-induced antinociception. Inhibition of S-nitrosylation dose-dependently and completely reversed CBD-mediated antinociception. Conclusion: Cannabidiol has an antinociceptive effect when administered systemically and this effect is mediated by the activation of PI3Kγ as well as by nitric oxide and subsequent direct S-nitrosylation of K<sub>ATP</sub> channels on peripheral nociceptors.</p></div>","PeriodicalId":19357,"journal":{"name":"Nitric oxide : biology and chemistry","volume":"146 ","pages":"Pages 1-9"},"PeriodicalIF":3.9,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140013091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protein S-nitrosylation is involved in valproic acid-promoted neuronal differentiation of adipose tissue-derived stem cells 蛋白 S-亚硝基化参与了丙戊酸促进脂肪组织源性干细胞神经元分化的过程

IF 3.9 2区生物学

Nitric oxide : biology and chemistry Pub Date : 2024-02-19 DOI: 10.1016/j.niox.2024.02.004

Kenta Kurokawa , Kazuyuki Sogawa , Takehito Suzuki , Yoko Miyazaki , Kazuaki Tanaka , Makoto Usami , Tatsuya Takizawa

{"title":"Protein S-nitrosylation is involved in valproic acid-promoted neuronal differentiation of adipose tissue-derived stem cells","authors":"Kenta Kurokawa , Kazuyuki Sogawa , Takehito Suzuki , Yoko Miyazaki , Kazuaki Tanaka , Makoto Usami , Tatsuya Takizawa","doi":"10.1016/j.niox.2024.02.004","DOIUrl":"10.1016/j.niox.2024.02.004","url":null,"abstract":"<div><p>Neuronal differentiation of adipose tissue-derived stem cells (ASCs) is greatly promoted by valproic acid (VPA) with cAMP elevating agents thorough NO signaling pathways, but its mechanism is not fully understood. In the present study, we investigate the involvement of protein S-nitrosylation in the VPA-promoted neuronal differentiation of ASCs. The whole amount of S-nitrosylated protein was increased by the treatment with VPA alone for three days in ASCs. An inhibitor of thioredoxin reductase (TrxR), auranofin, further increased the amount of S-nitrosylated protein and enhances the VPA-promoted neuronal differentiation in ASCs. On the contrary, another inhibitor of TrxR, dinitrochlorobenzene, inhibited the VPA-promoted neuronal differentiation in ASCs even with cAMP elevating agents, which was accompanied by unexpectedly decreased S-nitrosylated protein. It was considered from these results that increased protein S-nitrosylation is involved in VPA-promoted neuronal differentiation of ASCs. By the proteomic analysis of S-nitrosylated protein in VPA-treated ASCs, no identified proteins could be specifically related to VPA-promoted neuronal differentiation. The identified proteins, however, included those involved in the metabolism of substances regulating neuronal differentiation, such as aspartate and glutamate.</p></div>","PeriodicalId":19357,"journal":{"name":"Nitric oxide : biology and chemistry","volume":"145 ","pages":"Pages 21-32"},"PeriodicalIF":3.9,"publicationDate":"2024-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139921280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plasma levels of hydrogen sulfide and homocysteine correlate with the efficacy of antidepressant agents and serve as potential diagnostic and therapeutic markers 血浆中的硫化氢和同型半胱氨酸水平与抗抑郁药物的疗效相关，可作为潜在的诊断和治疗标志物

IF 3.9 2区生物学

Nitric oxide : biology and chemistry Pub Date : 2024-02-19 DOI: 10.1016/j.niox.2024.02.001

Jin-Zhi Lv , Xin-Zhe Du , Qian Wu , Yao Gao , Wentao Zhao , Xiao Wang , Yue Li , Jun-Xia Li , Xiaohua Cao , Xinrong Li , Yong Xu , Yu Zhang , Zhi-yong Ren , Sha Liu

{"title":"Plasma levels of hydrogen sulfide and homocysteine correlate with the efficacy of antidepressant agents and serve as potential diagnostic and therapeutic markers","authors":"Jin-Zhi Lv , Xin-Zhe Du , Qian Wu , Yao Gao , Wentao Zhao , Xiao Wang , Yue Li , Jun-Xia Li , Xiaohua Cao , Xinrong Li , Yong Xu , Yu Zhang , Zhi-yong Ren , Sha Liu","doi":"10.1016/j.niox.2024.02.001","DOIUrl":"10.1016/j.niox.2024.02.001","url":null,"abstract":"<div><h3>Objective</h3><p>Hydrogen sulfide (H<sub>2</sub>S) is associated with depressive-like behavior in rodents. We undertook cross-sectional and longitudinal analyses of plasma levels of H<sub>2</sub>S and its substrate homocysteine (Hcy) in depression and assessed the association of both parameters with psychopathology and cognitive function.</p></div><div><h3>Methods</h3><p>Forty-one patients suffering from depression (PSDs) and 48 healthy volunteers were recruited. PSDs were treated for 8 weeks. Analyzable data were collected from all participants for assessment of their psychopathology and cognitive function. Plasma was collected for determination of levels of H<sub>2</sub>S and Hcy, and data were correlated to determine their potential as plasma biomarkers.</p></div><div><h3>Results</h3><p>Cross-sectional analyses revealed PSDs to have a low plasma H<sub>2</sub>S level and high Hcy level. Longitudinal analyses revealed that 8 weeks of treatment reversed the changes in plasma levels of H<sub>2</sub>S and Hcy in PSDs. Plasma levels of H<sub>2</sub>S and Hcy were associated with psychopathology and cognitive function in depression. The area under the receiver operating characteristic curve (AUC) for a combination of plasma levels of H<sub>2</sub>S and Hcy and expression of the <em>TNF</em> gene (i.e., H<sub>2</sub>S–Hcy–<em>TNF</em>) was 0.848 for diagnosing depression and 0.977 for predicting the efficacy of antidepressant agents.</p></div><div><h3>Conclusion</h3><p>Plasma levels of H<sub>2</sub>S and Hcy reflect changes in psychopathology and cognitive function in depression and H<sub>2</sub>S–Hcy–<em>TNF</em> has the potential to diagnose depression and predict the efficacy of antidepressant medications.</p></div>","PeriodicalId":19357,"journal":{"name":"Nitric oxide : biology and chemistry","volume":"145 ","pages":"Pages 33-40"},"PeriodicalIF":3.9,"publicationDate":"2024-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139921279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Azobenzene-based colorimetric and fluorometric chemosensor for nitroxyl releasing 基于偶氮苯的硝基释放比色和荧光化学传感器。

IF 3.9 2区生物学

Nitric oxide : biology and chemistry Pub Date : 2024-02-15 DOI: 10.1016/j.niox.2024.02.003

Yang Zhou , Jiajun Chen , Yunxi Cui , Lingjuan Tang , Peixuan Wu , Peng Yu , Kun Fu , Zhicheng Sun , Yuanyuan Liu

{"title":"Azobenzene-based colorimetric and fluorometric chemosensor for nitroxyl releasing","authors":"Yang Zhou , Jiajun Chen , Yunxi Cui , Lingjuan Tang , Peixuan Wu , Peng Yu , Kun Fu , Zhicheng Sun , Yuanyuan Liu","doi":"10.1016/j.niox.2024.02.003","DOIUrl":"10.1016/j.niox.2024.02.003","url":null,"abstract":"<div><p>The precise release and characterization of nitroxyl (HNO) gas signaling molecule remain a challenge due to its short lifetime to date. To solve this issue, an azobenzene-based HNO donor (Azo-D1) was proposed as a colorimetric and fluorometric chemosensor for HNO releasing, to release both HNO and an azobenzene fluorescent reporter together. Specifically, the Azo-D1 has an HNO release half-life of ∼68 min under physiological conditions. The characteristic color change from the original orange to the yellow color indicated the decomposition of the donor molecule. In addition, the stoichiometry release of HNO was qualitatively and quantitatively verified through the classical phosphine compound trap. As compared with the donor molecule by itself, the decomposed product demonstrates a maximum fluorescence emission at 424 nm, where the increase of fluorescence intensity by 6.8 times can be applied to infer the real-time concentration of HNO. Moreover, cellular imaging can also be achieved using this Azo-D1 HNO donor through photoexcitation at 405 and 488 nm, where the real-time monitoring of HNO release was achieved without consuming the HNO source. Finally, the Azo-D1 HNO donor would open a new platform in the exploration of the biochemistry and the biology of HNO.</p></div>","PeriodicalId":19357,"journal":{"name":"Nitric oxide : biology and chemistry","volume":"145 ","pages":"Pages 49-56"},"PeriodicalIF":3.9,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139747161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role and mechanism of hydrogen sulfide in liver fibrosis 硫化氢在肝纤维化中的作用和机制。

IF 3.9 2区生物学

Nitric oxide : biology and chemistry Pub Date : 2024-02-13 DOI: 10.1016/j.niox.2024.02.002

Shaoyu Mao, Xuemei Wang, Miaoqing Li, Hanshu Liu, Hongxia Liang

引用次数: 0

Nitric oxide involvement in the disability and active disease of multiple sclerosis: Systematic review and meta-analysis 一氧化氮对多发性硬化症残疾和活动性疾病的影响：系统回顾和荟萃分析。

IF 3.9 2区生物学

Nitric oxide : biology and chemistry Pub Date : 2024-02-06 DOI: 10.1016/j.niox.2024.01.006

Brenda da Silva , Fernanda Tibolla Viero , Patrícia Rodrigues, Gabriela Trevisan

{"title":"Nitric oxide involvement in the disability and active disease of multiple sclerosis: Systematic review and meta-analysis","authors":"Brenda da Silva , Fernanda Tibolla Viero , Patrícia Rodrigues, Gabriela Trevisan","doi":"10.1016/j.niox.2024.01.006","DOIUrl":"10.1016/j.niox.2024.01.006","url":null,"abstract":"<div><h3>Background</h3><p>Multiple sclerosis (MS) is a chronic and immune-mediated disease of unknown etiology and leading to a physical and cognitive disability. Different studies suggest that nitrosative stress may play a pivotal role in the pathogenesis and disability in MS. Besides, reports evaluated NO and their metabolites, expressed by nitrite and nitrate (NOx) levels of MS patients compared with other pathologies, but did not evaluate disability and relapse/remission phases.</p></div><div><h3>Objective</h3><p>Thus, this study aimed to conduct a systematic review and meta-analysis of NOx levels in MS patients in relapse/remission phases and its involvement in patient disability.</p></div><div><h3>Methods</h3><p>The protocol was registered in PROSPERO (CRD42022327161). We used GRADE to estimate the articles' quality and evaluated the publication bias using Egger's and Begg's tests.</p></div><div><h3>Results</h3><p>Here, through a search in the Pubmed, Scopus, and EMBASE databases, 5.276 studies were found, and after the selection process, 20 studies were included in this systematic review and meta-analysis. The studies included data from 1.474 MS patients and 1.717 healthy controls, 1.010 RRMS and 221 primary progressive MS (PPMS).</p></div><div><h3>Conclusion</h3><p>NOx levels are increased in relapsing-remitting MS (RRMS) patients in the relapse phase. Also, NOx levels were increased in MS patients with higher disability. However, further studies are still needed to control lifestyle habits, pain, and MS treatment effects in biased NOx levels.</p></div>","PeriodicalId":19357,"journal":{"name":"Nitric oxide : biology and chemistry","volume":"145 ","pages":"Pages 8-20"},"PeriodicalIF":3.9,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139707449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nitric oxide: A potential etiological agent for vaso-occlusive crises in sickle cell disease 一氧化氮：镰状细胞病血管闭塞性危象的潜在致病因子

IF 3.9 2区生物学

Nitric oxide : biology and chemistry Pub Date : 2024-02-04 DOI: 10.1016/j.niox.2024.01.008

Parul Gupta, Ravindra Kumar

{"title":"Nitric oxide: A potential etiological agent for vaso-occlusive crises in sickle cell disease","authors":"Parul Gupta, Ravindra Kumar","doi":"10.1016/j.niox.2024.01.008","DOIUrl":"10.1016/j.niox.2024.01.008","url":null,"abstract":"<div><p>Nitric oxide (NO), a vasodilator contributes to the vaso-occlusive crisis associated with the sickle cell disease (SCD). Vascular nitric oxide helps in vasodilation, controlled platelet aggregation, and preventing adhesion of sickled red blood cells to the endothelium. It decreases the expression of pro-inflammatory genes responsible for atherogenesis associated with SCD. Haemolysis and activated endothelium in SCD patients reduce the bioavailability of NO which promotes the severity of sickle cell disease mainly causes vaso-occlusive crises. Additionally, NO depletion can also contribute to the formation of thrombus, which can cause serious complications such as stroke, pulmonary embolism <em>etc</em>. Understanding the multifaceted role of NO provides valuable insights into its therapeutic potential for managing SCD and preventing associated complications. Various clinical trials and studies suggested the importance of artificially induced nitric oxide and its supplements in the reduction of severity. Further research on the mechanisms of NO depletion in SCD is needed to develop more effective treatment strategies and improve the management of this debilitating disease.</p></div>","PeriodicalId":19357,"journal":{"name":"Nitric oxide : biology and chemistry","volume":"144 ","pages":"Pages 40-46"},"PeriodicalIF":3.9,"publicationDate":"2024-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139680067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A fluorogenic nitric oxide donor induced by yellow LED light for cells proliferation inhibition and imaging 一种由黄色 LED 光诱导的含氟一氧化氮供体，可用于细胞增殖抑制和成像

IF 3.9 2区生物学

Nitric oxide : biology and chemistry Pub Date : 2024-02-01 DOI: 10.1016/j.niox.2024.01.005

Wei Shen , Yuqing Yuan , Xia Liu , Jianze Jiang , Shian Yu , Haihua Zhou , Qing Zhu

引用次数: 0