Nitric oxide protects intestinal mucosal barrier function and prevents acute graft rejection after intestinal transplantation: A mini-review

IF 3.2 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nitric oxide : biology and chemistry Pub Date : 2024-05-26 DOI:10.1016/j.niox.2024.05.001

George J. Dugbartey , Deborah Nanteer , Ivy Osae

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Abstract

Intestinal transplantation is a complex technical procedure that provides patients suffering from end-stage intestinal failure an opportunity to enjoy improved quality of life, nutrition and survival. Compared to other types of organ transplants, it is a relatively new advancement in the field of organ transplantation. Nevertheless, great advances have been made over the past few decades to the present era, including the use of ischemic preconditioning, gene therapy, and addition of pharmacological supplements to preservation solutions. However, despite these strides, intestinal transplantation is still a challenging endeavor due to several factors. Notable among them is ischemia-reperfusion injury (IRI), which results in loss of cellular integrity and mucosal barrier function. In addition, IRI causes graft failure, delayed graft function, and decreased graft and recipient survival. This has necessitated the search for novel therapeutic avenues and improved transplantation protocols to prevent or attenuate intestinal IRI. Among the many candidate agents that are being investigated to combat IRI and its associated complications, nitric oxide (NO). NO is an endogenously produced gaseous signaling molecule with several therapeutic properties. The purpose of this mini-review is to discuss IRI and its related complications in intestinal transplantation, and NO as an emerging pharmacological tool against this challenging pathological condition. i

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一氧化氮保护肠粘膜屏障功能并预防肠道移植后急性移植物排斥反应：微型综述。

肠道移植是一项复杂的技术程序，它为患有终末期肠道功能衰竭的患者提供了一个改善生活质量、营养和存活率的机会。与其他类型的器官移植相比，肠道移植是器官移植领域相对较新的进展。尽管如此，从过去几十年到现在，我们已经取得了巨大的进步，包括使用缺血预处理、基因治疗以及在保存液中添加药理补充剂。然而，尽管取得了这些进步，由于多种因素的影响，肠道移植仍然是一项具有挑战性的工作。其中值得注意的是缺血再灌注损伤（IRI），它会导致细胞完整性和粘膜屏障功能丧失。此外，IRI 还会导致移植物失败、移植物功能延迟以及移植物和受体存活率降低。因此，有必要寻找新的治疗途径和改进的移植方案，以预防或减轻肠道 IRI。在许多正在研究的抗肠道 IRI 及其相关并发症的候选药物中，包括一氧化氮（NO）。一氧化氮是一种内源性产生的气体信号分子，具有多种治疗特性。本微型综述旨在讨论肠道移植中的 IRI 及其相关并发症，以及一氧化氮作为一种新出现的药理工具对这一具有挑战性的病理条件的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nitric oxide : biology and chemistry 生物-生化与分子生物学

CiteScore

7.50

自引率

7.70%

发文量

审稿时长

52 days

期刊介绍： Nitric Oxide includes original research, methodology papers and reviews relating to nitric oxide and other gasotransmitters such as hydrogen sulfide and carbon monoxide. Special emphasis is placed on the biological chemistry, physiology, pharmacology, enzymology and pathological significance of these molecules in human health and disease. The journal also accepts manuscripts relating to plant and microbial studies involving these molecules.