Nitric oxide : biology and chemistry最新文献

{"title":"Selective allosteric inhibition of cystathionine GAMMA-lyase as a broad anticancer strategy","authors":"Maureen Brusco, Konstantin Shatalin, Ashok Noothanaganti, Taryn Morningstar, Maria Ariza Mateos, Abhishek Kaushik, Katie Wang, Zixuan Wang, Claire Kim, Dimitris Placantonakis, Michael Pacold, Mirna Lechpammer, Alexander Serganov, Evgeny Nudler","doi":"10.1016/j.niox.2026.05.008","DOIUrl":"10.1016/j.niox.2026.05.008","url":null,"abstract":"","PeriodicalId":19357,"journal":{"name":"Nitric oxide : biology and chemistry","volume":"163 ","pages":"Page S7"},"PeriodicalIF":3.8,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148572690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydrogen sulfide protects cardiac mitochondria after global cerebral ischemia-reperfusion","authors":"David Centurión, Daniela Solís-Cruz, Ixchel Ramírez-Camacho, Araceli Sánchez-López","doi":"10.1016/j.niox.2026.05.010","DOIUrl":"10.1016/j.niox.2026.05.010","url":null,"abstract":"","PeriodicalId":19357,"journal":{"name":"Nitric oxide : biology and chemistry","volume":"163 ","pages":"Page S8"},"PeriodicalIF":3.8,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148588883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cell-specific effects of 3-mercaptopyruvate sulfurtransferase in obesity","authors":"Konstantinos Salagiannis , Gina Papadopoulou , Paraskevas Zampas , Antonia Katsouda , Andreas Papapetropoulos","doi":"10.1016/j.niox.2026.05.063","DOIUrl":"10.1016/j.niox.2026.05.063","url":null,"abstract":"","PeriodicalId":19357,"journal":{"name":"Nitric oxide : biology and chemistry","volume":"163 ","pages":"Page S25"},"PeriodicalIF":3.8,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148349555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SIMILARITIES IN THE MODE OF ACTION OF HCN AND NO AT THE BIOCHEMICAL LEVEL IN THE APPLE EMBRYONIC AXES","authors":"Maciej Piekarniak, Agnieszka Gniazdowska, Urszula Krasuska","doi":"10.1016/j.niox.2026.05.061","DOIUrl":"10.1016/j.niox.2026.05.061","url":null,"abstract":"","PeriodicalId":19357,"journal":{"name":"Nitric oxide : biology and chemistry","volume":"163 ","pages":"Page S25"},"PeriodicalIF":3.8,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148565705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuronal-Glial Interactions and CYSTATHIONINE BETA-SYNTHASE in Down Syndrome","authors":"Theodora Panagaki, Olivier Bremer, Csaba Szabo","doi":"10.1016/j.niox.2026.05.052","DOIUrl":"10.1016/j.niox.2026.05.052","url":null,"abstract":"","PeriodicalId":19357,"journal":{"name":"Nitric oxide : biology and chemistry","volume":"163 ","pages":"Page S22"},"PeriodicalIF":3.8,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148565863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CYANIDE DONOR THERAPY IMPROVES ENDOTHELIAL FUNCTION IN APOE/LDLR-/- MICE","authors":"Edyta Kus, Anna Bar, Zeinep Berkimbayeva, Jakub Dybas, Sylwester Mosiolek, Marek Grosicki, Lukasz Mateuszuk, Zuzanna Kurylowicz, Agnieszka Jasztal, Janusz Pyka, Elena Lytvynenko, Patrycja Kaczara, Csaba Szabo, Stefan Chlopicki","doi":"10.1016/j.niox.2026.05.036","DOIUrl":"10.1016/j.niox.2026.05.036","url":null,"abstract":"","PeriodicalId":19357,"journal":{"name":"Nitric oxide : biology and chemistry","volume":"163 ","pages":"Pages S16-S17"},"PeriodicalIF":3.8,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148566131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global deletion of 3-mercaptopyruvate sulfurtransferase results in albuminuria","authors":"Paraskevas Zampas, Maria Peleli, Iris-Sofia Bibli, Georgia-Ioanna Kelaidoni, Andreas Papapetropoulos","doi":"10.1016/j.niox.2026.05.082","DOIUrl":"10.1016/j.niox.2026.05.082","url":null,"abstract":"","PeriodicalId":19357,"journal":{"name":"Nitric oxide : biology and chemistry","volume":"163 ","pages":"Page S31"},"PeriodicalIF":3.8,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148572550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Resveratrol–hydrogen sulfide donor hybrid as a multi-target therapeutic strategy for allergic asthma","authors":"Martina Simonelli, Ida Cerqua, Danilo D’Avino, Elisabetta Granato, Alessandra Perrella, Sara Perna, Antonietta Rossi, Raffaele Capasso, Federica Sodano, Antonia Scognamiglio, Elisa Magli, Ferdinando Fiorino, Giuseppe Caliendo, Beatrice Severino, Angela Corvino, Fiorentina Roviezzo","doi":"10.1016/j.niox.2026.05.069","DOIUrl":"10.1016/j.niox.2026.05.069","url":null,"abstract":"","PeriodicalId":19357,"journal":{"name":"Nitric oxide : biology and chemistry","volume":"163 ","pages":"Page S27"},"PeriodicalIF":3.8,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148588912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stable isotope measurement of in vivo nitric oxide production in health and disease: an updated systematic review and meta-analysis","authors":"Thomas Loftus ,&nbsp;Jonas Benjamim ,&nbsp;Mauro Vaccarezza ,&nbsp;Blossom CM. Stephan ,&nbsp;Van Hoang Nguyen ,&nbsp;Ammar Ashor ,&nbsp;Mario Siervo","doi":"10.1016/j.niox.2026.01.001","DOIUrl":"10.1016/j.niox.2026.01.001","url":null,"abstract":"<div><h3>Background</h3><div>Nitric oxide (NO) is involved in the regulation of vascular, immune and metabolic functions. Physiological modelling of stable isotope tracers provides an accurate method to measure whole-body NO production in humans. A systematic review and meta-analysis of studies using stable isotope methods was conducted to measure <em>in vivo</em> NO production in healthy individuals and patients with various disease conditions, characterise production rates across different populations and assess methodological factors contributing to measurement variability.</div></div><div><h3>Methods</h3><div>PubMed/MEDLINE, Embase, Scopus and Web of Science databases were searched from inception to April 2025. Random-effect models were used to estimate of NO production. Risk of bias was assessed using the BIOCROSS scale for biomarker studies. Publication bias was evaluated by Funnel Plots and Egger's regression test.</div></div><div><h3>Results</h3><div>58 studies were included in the systematic review, and 42 had valid data to be included in the meta-analysis. Mean NO production in healthy adults was 0.74 (95 %CI 0.47, 1.00) μmol·kg⁻¹·hour⁻¹ and ranged from 0.73 to 4.89 μmol kg⁻¹·hour⁻¹ depending on methodology and population characteristics. NO production in cardiovascular diseases [0.19 (95 %CI 0.11, 0.28) μmol·kg⁻¹·hour⁻¹] and metabolic diseases [0.43 (95 %CI 0.21, 0.64) μmol·kg⁻¹·hour⁻¹] was associated with lower physiological NO production. Conversely, chronic kidney disease [5.42 (95 %CI 2.04, 8.81) μmol·kg⁻¹·hour⁻¹] and inflammatory conditions [1.35 (95 %CI 0.78, 1.92) μmol·kg⁻¹·hour⁻¹] were associated with increased NO production.</div></div><div><h3>Conclusions</h3><div>Chronic metabolic and cardiovascular diseases were overall characterised by a lower NO production. Standardisation of stable isotope protocols and reference ranges are needed to improve clinical utility for monitoring and therapy.</div></div>","PeriodicalId":19357,"journal":{"name":"Nitric oxide : biology and chemistry","volume":"161 ","pages":"Pages 18-26"},"PeriodicalIF":3.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146003902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Architectural modulation of polymeric hydrogen sulfide donors: Structure–responsive materials for controlled therapeutics","authors":"Vivek Pandey ,&nbsp;Nikky Sharma ,&nbsp;Tejasvi Pandey","doi":"10.1016/j.niox.2026.02.001","DOIUrl":"10.1016/j.niox.2026.02.001","url":null,"abstract":"<div><div>Hydrogen sulfide (H₂S), once regarded merely as a malodorous and toxic gas, has emerged as a vital endogenous signaling molecule with multifaceted physiological roles, encompassing neuromodulation, vasorelaxation, cytoprotection, and the regulation of inflammatory responses. Despite this growing recognition of its biological significance, the therapeutic translation of H₂S remains impeded by its physicochemical limitations as volatility, poor aqueous solubility, and rapid metabolic clearance. Addressing these challenges has stimulated the development of polymeric hydrogen sulfide (H₂S) donors engineered macromolecular systems capable of releasing H₂S in a temporally and spatially controlled manner. These structure-responsive materials offer a powerful platform wherein molecular architecture, donor chemistry, and supramolecular organization can be finely tuned to regulate release kinetics and responsiveness to physiological stimuli such as pH variations, redox gradients, and reactive oxygen species (ROS). This review consolidates recent advances in the design and application of polymeric and macromolecular H₂S donors, emphasizing the mechanistic relationships between structural parameters polymer topology, donor incorporation strategy, linker chemistry, hydrophilicity, and crosslinking density and their resultant release behaviors. Furthermore, it highlights the expanding biomedical landscape of these materials, discussing their therapeutic potential, translational challenges, and emerging strategies for precision engineering. By bridging molecular-level design with macroscopic functionality, this review aims to inform the rational development of next-generation polymeric H₂S donors that enable finely controlled spatiotemporal delivery and enhanced therapeutic efficacy.</div></div>","PeriodicalId":19357,"journal":{"name":"Nitric oxide : biology and chemistry","volume":"161 ","pages":"Pages 27-45"},"PeriodicalIF":3.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146157547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}