NPJ Digital Medicine最新文献_第8页

Conformal prediction enables disease course prediction and allows individualized diagnostic uncertainty in multiple sclerosis 适形预测能够预测病程，并允许多发性硬化症的个体化诊断不确定性

IF 15.2 1区医学

NPJ Digital Medicine Pub Date : 2025-04-24 DOI: 10.1038/s41746-025-01616-z

Akshai Parakkal Sreenivasan, Aina Vaivade, Yassine Noui, Payam Emami Khoonsari, Joachim Burman, Ola Spjuth, Kim Kultima

{"title":"Conformal prediction enables disease course prediction and allows individualized diagnostic uncertainty in multiple sclerosis","authors":"Akshai Parakkal Sreenivasan, Aina Vaivade, Yassine Noui, Payam Emami Khoonsari, Joachim Burman, Ola Spjuth, Kim Kultima","doi":"10.1038/s41746-025-01616-z","DOIUrl":"https://doi.org/10.1038/s41746-025-01616-z","url":null,"abstract":"Accurate assessment of progression and disease course in multiple sclerosis (MS) is vital for timely and appropriate clinical intervention. The gradual transition from relapsing-remitting MS (RRMS) to secondary progressive MS (SPMS) is often diagnosed retrospectively with a typical delay of three years. To address this diagnostic delay, we developed a predictive model that uses electronic health records to distinguish between RRMS and SPMS at each individual visit. To enable reliable predictions, conformal prediction was implemented at the individual patient level with a confidence of 93%. Our model accurately predicted the change in diagnosis from RRMS to SPMS for patients who transitioned during the study period. Additionally, we identified new patients who, with high probability, are in the transition phase but have not yet received a clinical diagnosis. Our methodology aids in monitoring MS progression and proactively identifying transitioning patients. An anonymized model is available at https://msp-tracker.serve.scilifelab.se/.","PeriodicalId":19349,"journal":{"name":"NPJ Digital Medicine","volume":"41 1","pages":""},"PeriodicalIF":15.2,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143872794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Global Initiative on AI for Health (GI-AI4H): strategic priorities advancing governance across the United Nations 人工智能促进健康全球倡议（GI-AI4H）：推动整个联合国治理的战略优先事项

IF 15.2 1区医学

NPJ Digital Medicine Pub Date : 2025-04-23 DOI: 10.1038/s41746-025-01618-x

Vijaytha Muralidharan, Madelena Y. Ng, Shada AlSalamah, Sameer Pujari, Kanika Kalra, Rajeshwari Singh, Denise Schalet, Tobi Olantuji, Rohit Malpani, Rubeta N. Matin, Jesutofunmi A. Omiye, Yu Zhao, Anita Sands, Andreas Reis, Jose Eduardo Diaz Mendoza, Tina Hernandez-Boussard, Roxana Daneshjou, Alain B. Labrique

引用次数: 0

Author Correction: Transforming healthcare through just, equitable and quality driven artificial intelligence solutions in South Asia. 作者更正：在南亚通过公正、公平和质量驱动的人工智能解决方案改变医疗保健。

IF 12.4 1区医学

NPJ Digital Medicine Pub Date : 2025-04-23 DOI: 10.1038/s41746-025-01639-6

Sushmita Adhikari, Iftikhar Ahmed, Deepak Bajracharya, Bishesh Khanal, Chandrasegarar Solomon, Kapila Jayaratne, Khondaker Abdullah Al Mamum, Muhammad Shamim Hayder Talukder, Sunila Shakya, Suresh Manandhar, Zahid Ali Memon, Moinul Haque Chowdhury, Ihtesham Ul Islam, Noor Sabah Rakhshani, M Imran Khan

引用次数: 0

Predictive modeling of hemodynamics during viscerosensory neurostimulation via neural computation mechanism in the brainstem 通过脑干神经计算机制对视觉神经刺激过程中的血液动力学进行预测建模

IF 15.2 1区医学

NPJ Digital Medicine Pub Date : 2025-04-23 DOI: 10.1038/s41746-025-01635-w

Jiho Lee, Junseung Mun, Minhye Choo, Sung-Min Park

{"title":"Predictive modeling of hemodynamics during viscerosensory neurostimulation via neural computation mechanism in the brainstem","authors":"Jiho Lee, Junseung Mun, Minhye Choo, Sung-Min Park","doi":"10.1038/s41746-025-01635-w","DOIUrl":"https://doi.org/10.1038/s41746-025-01635-w","url":null,"abstract":"Neurostimulation for cardiovascular control faces challenges due to the lack of predictive modeling for stimulus-driven dynamic responses, which is crucial for precise neuromodulation via quality feedback. We address this by employing a digital twin approach that leverages computational mechanisms underlying neuro-hemodynamic responses during neurostimulation. Our results emphasize the computational role of the nucleus tractus solitarius (NTS) in the brainstem in determining these responses. The intrinsic neural circuit within the NTS harbors collective dynamics residing in a low-dimensional latent space, which effectively captures stimulus-driven hemodynamic perturbations. Building on this, we developed a digital twin framework for individually optimized predictive modeling of neuromodulatory outcomes. This framework potentially enables the design of closed-loop neurostimulation systems for precise hemodynamic control. Consequently, our digital twin based on neural computation mechanisms marks an advancement in the artificial regulation of internal organs, paving the way for precise translational medicine to treat chronic diseases.","PeriodicalId":19349,"journal":{"name":"NPJ Digital Medicine","volume":"32 1","pages":""},"PeriodicalIF":15.2,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143866764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding contraceptive switching rationales from real world clinical notes using large language models 使用大型语言模型从真实世界的临床记录中理解避孕转换的原理

IF 15.2 1区医学

NPJ Digital Medicine Pub Date : 2025-04-23 DOI: 10.1038/s41746-025-01615-0

Brenda Y. Miao, Christopher Y. K. Williams, Ebenezer Chinedu-Eneh, Travis Zack, Emily Alsentzer, Atul J. Butte, Irene Y. Chen

引用次数: 0

A scoping review on the role of virtual walking intervention in enhancing wellness 虚拟步行干预在增进健康中的作用的范围综述

IF 15.2 1区医学

NPJ Digital Medicine Pub Date : 2025-04-23 DOI: 10.1038/s41746-025-01609-y

Yushen Dai, Jiaying Li, Yan Li, Frances Kam Yuet Wong, Mengqi Li, Chen Li, Ye Jia, Yueying Wang, Janelle Yorke

{"title":"A scoping review on the role of virtual walking intervention in enhancing wellness","authors":"Yushen Dai, Jiaying Li, Yan Li, Frances Kam Yuet Wong, Mengqi Li, Chen Li, Ye Jia, Yueying Wang, Janelle Yorke","doi":"10.1038/s41746-025-01609-y","DOIUrl":"https://doi.org/10.1038/s41746-025-01609-y","url":null,"abstract":"Virtual walking has the potential to be an adjunct to traditional physical therapy. This scoping review aims to synthesize evidence on the characteristics, effectiveness, feasibility, and neurological mechanism of virtual walking interventions on health-related outcomes. Articles in English were retrieved from twelve databases (January 2014–October 2024). Thirteen interventional studies were included, focusing on three types of virtual walking: passive observing moving (71.4%), arm swing locomotion (21.5%), and foot tracking locomotion (7.1%). Most studies (84.6%) involved individuals with spinal cord injuries, while the remaining studies focused on lower back pain (7.7%) and lower limb pain (7.7%). Over 70% of studies lasted 11–20 min, 1–5 weekly sessions for 10–14 days. Statistically significant findings included pain reduction (84.6%), improved physical function (mobility and muscle strength), and reduced depression. Mild adverse effects (fatigue and dizziness) were transient. Neurological evidence indicates somatosensory cortex activation during virtual walking, possibly linked to neuropathic pain.","PeriodicalId":19349,"journal":{"name":"NPJ Digital Medicine","volume":"108 1","pages":""},"PeriodicalIF":15.2,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143862922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Consumer insights from a feasibility study on remote and extended use of a novel non-invasive wearable fetal electrocardiogram monitor 消费者对一种新型无创可穿戴胎儿心电图监护仪远程和扩展使用可行性研究的见解

IF 15.2 1区医学

NPJ Digital Medicine Pub Date : 2025-04-21 DOI: 10.1038/s41746-025-01628-9

Debjyoti Karmakar, Tarini Paul, Emerson Keenan, Marimuthu Palaniswami, Kaitlin Constable, Erica Spessot, Fiona Brownfoot

{"title":"Consumer insights from a feasibility study on remote and extended use of a novel non-invasive wearable fetal electrocardiogram monitor","authors":"Debjyoti Karmakar, Tarini Paul, Emerson Keenan, Marimuthu Palaniswami, Kaitlin Constable, Erica Spessot, Fiona Brownfoot","doi":"10.1038/s41746-025-01628-9","DOIUrl":"https://doi.org/10.1038/s41746-025-01628-9","url":null,"abstract":"The COVID-19 pandemic accelerated the adoption of telehealth and remote monitoring in obstetric care. This study assessed pregnant patients’ perceptions before and after using a novel non-invasive fetal electrocardiogram (NI-FECG) device. The trial is prospectively registered on the Australia New Zealand Clinical Trials Registry (ANZCTRN12621001260819; submitted June 9th, 2021; approved September 17th, 2021). Seventy participants from 36 weeks’ gestation completed pre- and post-use surveys. Interest in continuous and home fetal monitoring was high (79% and 90%, respectively). Post-use, 89% reported satisfaction; over 90% comfortable wearing and removing the sensor. Extended use was acceptable to 76%, and only 3% reported high skin irritation. Sentiment analysis highlighted themes of reassurance, convenience, and reduced anxiety. Some suggested smaller, wireless design. Analysis by natural language processing and clustering provided deeper insights. Findings support strong interest in at-home fetal monitoring; further refinement and education are needed to enhance acceptability. Future research should assess long-term effects on anxiety and clinical outcomes.","PeriodicalId":19349,"journal":{"name":"NPJ Digital Medicine","volume":"30 1","pages":""},"PeriodicalIF":15.2,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143853398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Germany and Europe lead digital innovation and AI with collaborative health data use at continental level 德国和欧洲在数字创新和人工智能方面处于领先地位，并在欧洲大陆层面协作使用卫生数据

IF 15.2 1区医学

NPJ Digital Medicine Pub Date : 2025-04-20 DOI: 10.1038/s41746-025-01631-0

Daniel C. Baumgart, Joseph C. Kvedar

引用次数: 0

Advancing perioperative care with digital applications and wearables 利用数字应用和可穿戴设备推进围手术期护理

IF 15.2 1区医学

NPJ Digital Medicine Pub Date : 2025-04-19 DOI: 10.1038/s41746-025-01620-3

Ben Li, Arjun Mahajan, Dylan Powell

引用次数: 0

Overcoming barriers in the use of artificial intelligence in point of care ultrasound 克服人工智能在护理点超声应用中的障碍